Gene PPP5C in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP5C
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP157_AA protein Get Run
SpurP157_AA_187-496 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
TPR_12 Tetratricopeptide repeat 25-61 5.5e-08 22.1 Pfam-A 40-76 (78) alignment
Range on Protein: 25-61
Range on HMM: 40-76/78.0
EVDREKAEALKDKANTYFKAQDFQQAITYYSEALEIN
. . . | || . ||.| ...|...|. |. .|||| 
ddhpdtaralnnlanlylalgdydeAleylekAleia

RPN7 26S proteasome subunit RPN7 25-127 2e-07 17.0 Pfam-A 30-134 (177) alignment
Range on Protein: 25-127
Range on HMM: 30-134/177.0
EVDREKAEALKDKANTYFKAQDFQQAITYYSEALEiNPTVAAFHGNRSFAYLKTECFGSALEDASKALELDKSYIKG---YYRRATANMALGKIKIALKD
... . ..||.|.|. |.|. |...|. .||.|..   | .  . .  .. .... |    . .|| ||  ||...      ||.  ... | ...| ..
likesirraledlaehYlkigdleeAlkaysrard.yctslkhkidmllnvirvsiffndwslvskylekaksllekggdwerrnrlkvyeGlaalanrk

YEMVVK
.. ...
fkeaae

TPR_11 TPR repeat 29-96 3.5e-21 64.3 Pfam-A 1-69 (69) alignment
Range on Protein: 29-96
Range on HMM: 1-69/69.0
EKAEALKDKANTYFKAQDFQQAITYYSEALEINPTVAAFHGNRSFAYLKTE-CFGSALEDASKALELDK
|.||||| ..| .||..|...|| .|..|||..|  |  . |.. ||||    . .||||..||||||.
enAealkelGnalfkegdydeAieayekAleldpnnaelyynlAlaylklgkdyeeAledyekAleldP

TPR_1 Tetratricopeptide repeat 31-63 9.4e-13 36.9 Pfam-A 1-33 (34) alignment
Range on Protein: 31-63
Range on HMM: 1-33/34.0
AEALKDKANTYFKAQDFQQAITYYSEALEINPT
|.||. ..|.|.| .....|. ||..|||.||.
akalynlGnaylklgkydeAleyyekALelnPn

TPR_2 Tetratricopeptide repeat 31-63 2.2e-10 29.5 Pfam-A 1-33 (34) alignment
Range on Protein: 31-63
Range on HMM: 1-33/34.0
AEALKDKANTYFKAQDFQQAITYYSEALEINPT
||||   .. |.|..|...|. .. .|||..|.
aealynlGlayyklgdyeeAleafekAleldPn

TPR_14 Tetratricopeptide repeat 31-68 2.3e-06 17.7 Pfam-A 1-38 (44) alignment
Range on Protein: 31-68
Range on HMM: 1-38/44.0
AEALKDKANTYFKAQDFQQAITYYSEALEINPTVAAFH
.||| . |. .. ..|...|| .. .||. .|. |...
peallalarallalGdpdeAiallrralalaPddaeal

TPR_8 Tetratricopeptide repeat 33-62 6.1e-06 15.4 Pfam-A 3-32 (34) alignment
Range on Protein: 33-62
Range on HMM: 3-32/34.0
ALKDKANTYFKAQDFQQAITYYSEALEINP
|.  .. .|..  |. .|. |. .|||..|
ayynlGdiYrqlGdydkAkeylekalelkp

TPR_16 Tetratricopeptide repeat 36-78 5.6e-06 16.6 Pfam-A 2-44 (65) alignment
Range on Protein: 36-78
Range on HMM: 2-44/65.0
DKANTYFKAQDFQQAITYYSEALEINPTVAAFHGNRSFAYLKT
..|. ...|.|...|. ....||. .|  | .. ..  |.|. 
alArallraGdydeAlaaleaalalaPeaaeallllaeallrq

TPR_7 Tetratricopeptide repeat 38-60 9.3e-07 17.5 Pfam-A 6-30 (36) alignment
Range on Protein: 38-60
Range on HMM: 6-30/36.0
ANTYFKAQDFQQAITYYSEAL--EI
|..|.. .|...||..| .||  . 
arlysrlgdyekAielyeraLaltk

TPR_9 Tetratricopeptide repeat 39-96 2.7e-07 19.8 Pfam-A 3-60 (73) alignment
Range on Protein: 39-96
Range on HMM: 3-60/73.0
NTYFKAQDFQQAITYYSEALEINPTVAAFHGNRSFAYLKTECFGSALEDASKALELDK
..|. ..||..|. ..   |...|  .  .  | ... ...|.  |||| . .|||..
aiylreedferALavverllllaPddpyerRDrGlllaqlgclaaAledLeaflelcp

TPR_11 TPR repeat 84-130 1e-09 27.5 Pfam-A 22-69 (69) alignment
Range on Protein: 84-130
Range on HMM: 22-69/69.0
ALEDASKALELDKSYIKGYYRRATANMALGK-IKIALKDYEMVVKYRP
|.|  .||||||... . ||..| | . |||  . ||.|||......|
AieayekAleldpnnaelyynlAlaylklgkdyeeAledyekAleldP

TPR_1 Tetratricopeptide repeat 100-132 1.2e-07 20.8 Pfam-A 2-34 (34) alignment
Range on Protein: 100-132
Range on HMM: 2-34/34.0
KGYYRRATANMALGKIKIALKDYEMVVKYRPND
| .|... | . ||| . ||..|| ... .||.
kalynlGnaylklgkydeAleyyekALelnPnn

TPR_2 Tetratricopeptide repeat 100-132 7e-06 15.5 Pfam-A 2-34 (34) alignment
Range on Protein: 100-132
Range on HMM: 2-34/34.0
KGYYRRATANMALGKIKIALKDYEMVVKYRPND
...|... | ..||. . ||...| .... ||.
ealynlGlayyklgdyeeAleafekAleldPnn

PPP5 PPP5 TPR repeat region 138-233 9.2e-35 109.0 Pfam-A 1-95 (95) alignment
Range on Protein: 138-233
Range on HMM: 1-95/95.0
KYTECSKLVKQQAFERAIRGhTEEKKSVIDTINLENMIIEGDYEGPALENDKVTKDFMVKLLQHFKDEKALHRKFAYTMLVQILAMFKKLPSLCDI
|..||.||||..|||.||    |||.|| ..|..|.. || ||.|| ||..|||..|. .||..||..| ||.||.|..|...  ..|||||| .|
KlkeCeklvkkiaFekAIev.deekrsvaesidiesieieddYdgprledekvtlefvkelleefkkqkklhkkfvyqilldvkellkklpslvei

subfamily_PPP5C_pd Subfamily PPP5C 176-495 1.1e-184 605.8 In-house 2-322 (322) alignment
Range on Protein: 176-495
Range on HMM: 2-322/322.0
IEGDYEGPALENDKVTKDFMVKLLQHFKDEKALHRKFAYTMLVQILAMFKKLPSLCDITIPEGKKFTICGDIHGQFYDLLNIFEINGLPSEDNPYLFNGD
.| .|.|| ||..|.||.|. .||..||..|.||.|.|...|... ...||||||..|||.|.||.|.||||||||||||||||.||||||.||||||||
vedsydgpkleeekitkefvkellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGd

FVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMNQMYGFYGEVRSKYTNQMADLFQEVYNWLPLAQLINKKVMVMHGGLFSQDNVTIDDLRIIDR
|||||||||||||||.|||||||.||.|||||||||.||..||| |||..|||...||||.||.||||||..||.||.|.||||||.|.||.|||| |||
fvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidr

NRQPPESGLMCELLWSDPQPRPGRSPSKRGVGIQFGPDVTKKFLEHNNLEYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFINL-GADLKP
|.||||.||..||||||||...||||||||||.|||||||||||..||||.|.||||||..||||.||||.||||||||||||.|||||||.| |.|||.
naqppeegllvellwsdpqeanGrspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlkl

NFKTYEAVPHPNVRPMAYANS
.|||.|||.||.|.|||||||
kfktfeavehpdvkpmayans

subfamily_PPP7C_pd Subfamily PPP7C 176-377 3.5e-62 203.3 In-house 2-203 (383) alignment
Range on Protein: 176-377
Range on HMM: 2-203/383.0
IEGDYEGPALENdKVTKDFMVKLLQHFKDEKALHRKFAYTMLVQILAMFKKLPSLCDITIPEGKKFTICGDIHGQFYDLLNIFEINGLPSEDNPYLFNGD
.| .|.|| |.   .||| . ||...|| .| || |.  ..| .   ..|.||..  ..    |. |.|||.||.. ||| |.  ||||||.|||.||||
vedsytgprlsl.pltkdeveklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGd

FVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMNQMYGFYGEVRSKY---TNQMADLFQEVYNWLPLAQLINKKVMVMHGGLFsqDNVTIDDLRI
|||||. |||..| |. . |.|| ...| |||||   .|  |||  || |||   ....  |...|. ||||| ||..|....|||.   |.  .. |  
fvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGis..dktdlelldk

IDRNR
|.|..
iersk

0045823 Metallo-dependent phosphatases 188-496 1.4e-105 346.6 In-house 23-338 (473) alignment
Range on Protein: 188-496
Range on HMM: 23-338/473.0
DKVTKDFMVKLLQHFKDEKALHRKFAYTMLVQILAMFKKLPSLCDITIpegkKFTICGDIHGQFYDLLNIFEINGLPSEdNPYLFNGDFVDRGSFSVEVI
. ... .. .|..|.| |. |. .... .| ..  ..|| |.| ...     .....||||||..|||...|..|.|.| . ..|.||.||||..|.||.
illglldldlliehlkkegllpeedllklldeakeilkkepnllelsm....rivviGDiHGqlddLlrllekigfppe.drlvflGDlvDrGpdslevl

LTLFGFKLLYPDHFHLSRGNHESDTMNQMYGFYGEVRSKYTNQMADLFQEVYNWLPLAQLINKKVMVMHGGLFSQDnVTIDDLRIIDRNRQPPESGLMCE
. |. .|..||....| |||||.  .|..|||..|.. ||. .. . |.|. ..|||| .|..|. ..||||...   ..|..| |.| ...|..||...
elllalkikypgnvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdl.plldqireierpleipddgllld

LLWSDPQPRPG--------RSPSKRGVGIQFGPDVTKKFLEHNNLEYIVRSHEVKNDGYEVTHDGK------CITVFSAPNYCDQIGNKGAFINLGADLk
||||||..  |        . .|.||.| .||||....||..|.| .|||.|..  .|||...|||      .||||||||||.. ||..|.. .. || 
llwsdPweddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.

PNFKTYEAVPHPNVRPMAYANSM
..|......|||...|... . .
isfiqfdpsphplilplfldvfl

0049330 Metallo-dependent phosphatases 189-488 4.5e-95 311.2 In-house 11-305 (309) alignment
Range on Protein: 189-488
Range on HMM: 11-305/309.0
KVTKDFMVKLLQHFKDEKALHRKFAYTMLVQILAMFKKLPSLCDITipegKKFTICGDIHGQFYDLLNIFEINGLPSEdNPYLFNGDFVDRGSFSVEVIL
....... .|..... .| |. ......| ..  ..|. |.| ...     .....||||||..|||...|..|.|.| . ..|.||.||||..|.||.|
elilslldllielllklkllseeellllllkakeilksepnllels....mrivviGDiHGqlddLlrllekigfppe.drlvflGDlvdrGpdslevll

TLFGFKLLYPDHFHLSRGNHESDTMNQMYGFYGEVRSKYTNQMADLFQEVYNWLPLAQLINKKVMVMHGGLFSQDnVTIDDLRIIDRNRQPPESGLMCEL
.|. .||||||...| |||||.  .|..|||..|.  ||  .. . |......|||| .|..|....||||...  ...|..| ..| ...|. ||.|.|
lllalkllypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdl.llldqirelerpleipldgllcdl

LWSDPQ-PRPGRSPSKRGVGIQFGPDVTKKFLEHNNLEYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFINLGADLKPNFKTYEAVPHPNV
|||||.  |.|  |..||.|. ||......||..|.|..|.|.|..  .||.. .|||.||||||||||...||.||.. .. ||...|...|.||.. .
lwsdplpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpllll

R
 
l

0053225 Metallo-dependent phosphatases 193-483 6.3e-88 287.9 In-house 7-292 (293) alignment
Range on Protein: 193-483
Range on HMM: 7-292/293.0
DFMVKLLQHFKDEKALHRKFAYTMLVQILAMFKKLPSLCDITipegKKFTICGDIHGQFYDLLNIFEINGLPSEdNPYLFNGDFVDRGSFSVEVILTLFG
 .. .|.....  | |. ......| ..  ..|| |.| ...     .....|||||...|||...|. |.|.| . ..|.||.||||..|.||.. |. 
llldllielllllkllseeelllllleakeilkkepnllels....mriyviGDiHGnlddLlallekigfppe.drlvflGDlvdrGpdslevlellla

FKLLYPDHFHLSRGNHESDTMNQMYGFYGEVRSKY-TNQMADLFQEVYNWLPLAQLINKKVMVMHGGLfSQDNVTIDDLRIIDRNRQPPESGLMCELLWS
.||||||...| |||||.  .|..|||..|.  ||   .. | .......|||| ||..|....|||| | | ...|..| |.|  ..|. ||...||||
lkllypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGl.spdlslldqireinrplriplegllldllws

DPQPRPGRSPSKRGVGIQFGPDVTKKFLEHNNLEYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFINLGADLKPNFKTYEAVP
||. . |  ||.||.|. ||......||..|.|..|.|.|.|  |||.. .|||..||||||||... ||.||.. |. .|...||....|.
dpdlwsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapvl

subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 193-479 1.6e-80 263.3 In-house 5-291 (298) alignment
Range on Protein: 193-479
Range on HMM: 5-291/298.0
DFMVKLLQHFKDEKALHRKFAYTMLVQIL----AMFKKLPSLCDITIPegkkFTICGDIHGQFYDLLNIFEINGLPSEDNpYLFNGDFVDRGSFSVEVIL
......|.  . || | ..   . . ...     .||| .|| ..  |     ..|||||||. ||| .|. .| | . | ||| ||.||||....|||.
ellievlsvslsekkltkvikeedveklielakkifkkqkslvevdap....ikvcGdihGqysdllrlfdkagfppdan.ylflGdyvdrGrqnleviv

TLFGFKLLYPDHFHLSRGNHESDTMNQMYGFYGEVRSKY-TNQMADLFQEVYNWLPLAQLINKKVMVMHGGLfSQDNVTIDDLRIIDRNRQPPESGLMCE
 |. .|. ||..| | |||||  ..|..|||| |.. .|   ..   ||.|.|.|||. || .... ||||| |.  ...|.|| . |  ...|. |  .
lllaykvkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGl.skklksldqlrelkrpfdskeeslaid

LLWSDPQP-RPGRSPSKRGVGIQFGPDVTKKFLEHNNLEYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFINLGADLKPNFKTY
|||.||.    | ....|||...|| || |..||. ... .||.| | .||||   . | .|.||||.||.|  |  |.... ..|.  |. .
llwadpenavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevl

subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 193-483 1e-68 224.8 In-house 5-295 (299) alignment
Range on Protein: 193-483
Range on HMM: 5-295/299.0
DFMVKLLQHFKDEKALHRKFAYTMLVQILAMFKKLPSLCDITIPEGKKFTICGDIHGQFYDLLNIFEINGLPSEDNpYLFNGDFVDRGSFSVEVILTLFG
....|||.  . || | .      |... |. |.        .       .|||||||. ||| ||...|.| . | .|| ||.||||   .|.|  |. 
ellskllnvgmsekrltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvn.flflgdyvdrgrqnlelitlllc

FKLLYPDHFHLSRGNHESDTMNQMYGFYGEVRSKYTN-QMADLFQEVYNWLPLAQLINKKVMVMHGGLfSQDNVTIDDLRIIDRNRQPPESGLMCELLWS
||. ||..|.. |||||  ..|..|||| |.  .|.  ..  .||. ....||. ||. ....||||| |    |.| || . | ..||.  |  .|||.
fkikyperffmlrgnhecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhggl.spklqtldqlrdltrpqdppnpslgidllwa

DPQP-RPGRSPSKRGVGIQFGPDVTKKFLEHNNLEYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFINLGADLKPNFKTYEAVP
||.    .  .  |||   ||.|| .. ... ... . |.|.| .||||   . | .|.|||| || |. |  | ...  .|   |. ..  |
dpdqsvkdwlanvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptp

subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 195-476 6.7e-63 205.4 In-house 3-283 (290) alignment
Range on Protein: 195-476
Range on HMM: 3-283/290.0
MVKLLQHFKDEKALHRKFAYTMLVQILAMFKKLPSLCDITIPegkkFTICGDIHGQFYDLLNIFEINGLPSeDNPYLFNGDFVDRGSFSVEVILTLFGFK
|.. |...   .|.  |  ...| .|  ... ||.| ..  |     .| ||||||. .||. |.  | |  .  .|| ||.||||. |.|| | || .|
miehllkygvldafsdkdileilekieeileplpalleveap....ivivgdihgqldallryfdavgypp.kvkflflgdyvdrgakslevslllfcyk

LLYPDHFHLSRGNHESDTMNQMYGFYGEVRSKYTNQMADLFQEVYNWLPLAQLINKKVMVMHGGLfSQDNVTIDDLRIIDRNRQP--PESGLMCELLWSD
..|. . || |||||   .|..|||. |.  | ....   .|.|.. |.|   ...|.. ||||. ||.  . . |. . . | |   . ||. .|||.|
iryskkvhllrgnhevrkvnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggi.sqkiesweslkalkkprvpltcdeglqvdllwad

PQP---RPGRSPSKRGVGIQFGPDVTKKFLEHNNLEYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFINLGADLKPNF
|.       .   .|.. . || ..  ..|..  |. |||.||||..|..   | |..|||||| |. .  | || ...   |. ..
ptrdkddtialnkqraisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsi

subfamily_PPP3C_pd Subfamily PPP3C 196-489 5.2e-78 255.8 In-house 29-329 (452) alignment
Range on Protein: 196-489
Range on HMM: 29-329/452.0
VKLLQHFKDEKALHRKFAYTMLVQILAMFKKLPSLCDITIPegkkFTICGDIHGQFYDLLNIFEINGLPSEDNpYLFNGDFVDRGSFSVEVILTLFGFKL
  | .||. |  |... |  .. .  ...|| ..| ..  |     |..|||||||||||..||..| |.. . ||| ||.||||.||.|..| |.  |.
evlkehflkegrleeeaalkiieeaakllkkektlleveaP....itviGdihGqfydllklfevgGdPastk.ylflGdyvdrGyfsiecvlylyalki

LYPDHFHLSRGNHESDTMNQMYGFYGEVRSKYTNQMADLFQEVYNWLPLAQLINKKVMVMHGGLfSQDNVTIDDLRIIDRNRQPPESGLMCELLWSDPQP
 ||....| |||||.  . . . |  |...||.... | . | .. |||| |.|.. . .|||| | .  ..||.. .|| ..||.||..|.||||||  
aypstlfllrGnhecrhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGl.speikslddikkldrfkeppasGplcdllWsdPle

RPGRSP--------SKRGVGIQFGPDVTKKFLEHNNLEYIVRSHEVKNDGYEVTHD------GKCITVFSAPNYCDQIGNKGAFINLGADlKPNFKTYEA
. | .         | ||  . ..   . .||..|.|  |.|.||....||.. ..         ||.||||||.|   ||.| ...  . . | . ...
dygeekteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyenn.vmnirqfns

VPHPNVRP
.|||   |
sphpywlp

subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 206-475 7.9e-68 221.4 In-house 8-275 (287) alignment
Range on Protein: 206-475
Range on HMM: 8-275/287.0
KALHRKFAYTMLVQILAMFKKLPSLCDITIPegkkFTICGDIHGQFYDLLNIFEINGLPSeDNPYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSR
.|.  |  ...| .|  ... ||.| ... |     ||.||||||. |||.||.  | .. .  ||| ||.||||. |.||.| || .|..|| . || |
dafsdkdilevlekieeileplpalleveap....itivGdihGqlddllrifnavGaap.kvqylflGdyvdrGakslevslllfslkiaypkkvhllr

GNHESDTMNQMYGFYGEVRSKYTNQMADLFQEVYNWLPLAQLINKKVMVMHGGLfSQDNVTIDDLRIIDRNRQPPES--GLMCELLWSDPQPRP-GRSP-
||||   .|..|||. |.. |. ...   |..|.. |||   ..|... ||||. |..  ..|.|. . . ..| .   ||. .|||.||.    .  . 
GnhevkkinklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGi.spklksldslkalkkpttplacdeglqvdllwadpekdaktfeln

SKRGVGIQFGPDVTKKFLEHNNLEYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFINLGADLKPN
  |..   ||  .  ..|.. ... |||.|||...||.   | ...|||||| |. .  | || . .   |. .
kiraisvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslels

PP2Ac_SM00156 209-481 1.3e-103 338.8 In-house 2-269 (271) alignment
Range on Protein: 209-481
Range on HMM: 2-269/271.0
HRKFAYTMLVQILAMFKKLPSLCDITipegKKFTICGDIHGQFYDLLNIFEINGlPSEDNPYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNH
... ....| .. ...|. ..|....    .. |..||||||..|||...| .| ......|.|.||.||||..|.||||.|| .|.|||....| ||||
skeevlelleevkeilkqeknlvevs....apvtvvGdihGqlddllrllelag.eppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnH

ESDTMNQMYGFYGEVRSKYTNQMADLFQEVYNWLPLAQLINKKVMVMHGGLFSqDNVTIDDLRIIDRNRQPPESGLMCELLWSDP-QPRPGRSPSKRGVG
||. .|..|||. ||. ||.... . |.|....|||| |...|...||||| . .  ..||.| ..|....||.||...|||||| |. .| .|||||..
EsssvnkiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlsp.eleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrgls

IQFGPDVTKKFLEHNNLEYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFINLGADLKPNFKTYEA
..||.|..|.||..|||..|.|.|||...|||. .|.|..|.||||||||. .||.|....  .||........
vvFgedavkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlke

subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 214-472 4.2e-63 206.4 In-house 9-264 (284) alignment
Range on Protein: 214-472
Range on HMM: 9-264/284.0
YTMLVQILAMFKKLPSLCDITIPegkkFTICGDIHGQFYDLLNIFEINGLPSEDNpYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTM
 |.|.. ...|.| | | ..  |      ||||||||| ||| .|. ||.|   | ||| ||.||||   .| || || .|...|.|| . |||||   .
etllfhafsifnkqpmlievnsp....inicgdihgqfsdllrlfdkngfphran.ylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecsli

NQMYGFYGEVRSKYTNQ-MADLFQEVYNWLPLAQLINKKVMVMHGGLfSQDNVTIDDLRIIDRNRQPPES-GLMCELLWSDPQP-RPGRSPSKRGVGIQF
|..|||| |.. .| .  .   |. |.  .||. |. .....||||. |.    . .|| | |  . ||   |  ..|||||   . |  |  |||   |
nkiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggv.skmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvf

GPDVTKKFLEHNNLEYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFINLGADL
| |  .|.|.. ... .||.|.| .||||.  . . .|.|||| || |. |  | . .  .|
gsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknl

subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 214-471 7.1e-44 143.2 In-house 12-289 (302) alignment
Range on Protein: 214-471
Range on HMM: 12-289/302.0
YTMLVQILAMFKKLPSLCDITIPegkkFTICGDIHGQFYDLLNIFEINGLPSE----------DNPYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHL
.... .. ...||  .| .|. |     || ||||||| ||. |.  .    |           . ..| ||.||||| |.| |  .| .|.||| .. |
lllieaviellkkektlaeispP....vtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyil

SRGNHESDTMNQMYGFYGEVRSKYTN----QMADLFQEVYNWLPLAQLINKKVMVMHGGLfSQDNVTIDDLRIIDRNRQP-PESGLMCELLWSDPQPR--
 |||||. ..|  ||| .|.  ....    .. . |.||. ..||| |. .|.. .|||. |.   ...|.. |.|  .   |  |  .||..||     
lrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggi.spklesledikkikrplkevtedslaqdllfadpldvql

---PGRSP-----SKRGVGIQFGPDVTKKFLEHNNLEYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFINLGAD
   . . |      .||. . |     ... .. ||. |||.| .   |.    | | .|.||||.| ... |||| ... ..
laavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtn

subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 214-471 9.8e-44 142.7 In-house 13-290 (302) alignment
Range on Protein: 214-471
Range on HMM: 13-290/302.0
YTMLVQILAMFKKLPSLCDITIPegkkFTICGDIHGQFYDLLNIFEINGLPSE----------DNPYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHL
.... .. ...||  .| .|. |     || ||||||| ||. |.  .    |           . ..| ||.||||| |.| |  .| .|.||| .. |
lllieaviellkkektlaeispP....vtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyil

SRGNHESDTMNQMYGFYGEVRSKYTN----QMADLFQEVYNWLPLAQLINKKVMVMHGGLfSQDNVTIDDLRIIDRNRQP-PESGLMCELLWSDPQPR--
 |||||. ..|  ||| .|. .....    .. . |.||. ..||| |. .|.. .|||. |.   ...|.. |.|  .   |  |  .||..||     
lrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggi.spklesledikkikrplkevtedslaqdllfadpldvql

---PGRSP-----SKRGVGIQFGPDVTKKFLEHNNLEYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFINLGAD
   . . |      .||. . |     ... .. ||. |||.| .   |.    | | .|.||||.| ... |||| ... ..
laavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtn

PPP_3 215-480 1.7e-101 331.8 In-house 5-270 (271) alignment
Range on Protein: 215-480
Range on HMM: 5-270/271.0
TMLVQILAMFKKLPSLCDITIPEGKKFTICGDIHGQFYDLlNIFEINGLPSEDNPYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMN
. |.... . |....  ....   .. |.|||||||..|| .... ||.||... |||.||.||||..|.||.|.|. .|..||...|| ||||||...|
nelkelvkklkeilekesnlveisapvtvcGDiHGqldDL.lelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrqin

QMYGFYGEVR-SKYTNQMADLFQEVYNWLPLAQLINKKVMVMHGGLFSQDNvTIDDLRIIDRNRQPPESGLMCEL-LWSDPQPRPGRSPSKRGVGIQFGP
..|||. ||  .|..... . .|||...||||.||..||.|.||||... . ..|... ..|... ||.|....| |.|||. . | ..||||.|. |||
kvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsik.sldqikklerkievpeegklldlllssdpekeeglenskrGagllFgp

DVTKKFLEHNNLEYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFINLGADLKPNFKTYE
|||..|||.|.|..|.|.||.|..|||..||||..|||||||||....|.||...|...|...||..|
dvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle

PPP_1 215-467 2.7e-95 311.6 In-house 4-263 (264) alignment
Range on Protein: 215-467
Range on HMM: 4-263/264.0
TMLVQILAMFKKLPSLCDITIPEGKKFTICGDIHGQFYDLlNIFEINGLPSEDNPYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMN
. |.... . |.|..  ....   .. |.||||||||.|| ...  .|.||... |||.||.||||..|||..|.|. .|| ||....| ||||||....
eelaelkkklkellnkeenllevseeitvcGDiHGqfdDL.lklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvt

QMYGFYGEVR-SKYTNQMADLFQEVYNWLPLAQLINKKVMVMHGGLFSQDNvTIDDLRIIDRNRQPPESGLMCELL--------WSDPQPRPGRSPSKRG
..|||. ||.  ||.... .....|...||||.||..|....|||| .. . ..|. |...|... ||.| .|.||        ..|.. . . . |.||
kvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeld.lldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

VGIQFGPDVTKKFLEHNNLEYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFIN
.| .||.|||.|||..|||..|.|.||||..|||.....|..|.|||.||... .|.||...
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk

subfamily_PPP1C_pd Subfamily PPP1C 216-478 3.2e-84 275.4 In-house 18-275 (282) alignment
Range on Protein: 216-478
Range on HMM: 18-275/282.0
MLVQILAMFKKLPSLCDITIPegkkFTICGDIHGQFYDLLNIFEINGLPSEDNpYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMNQ
.| .  ..... | | ... |     .|.||||||..|||..||..| |.| | ||| ||.||||..|.|.|. |. .|. ||....| ||||||  .|.
llkkareillsqpilleleaP....vkivgdihGqyadllrlfetsgaPpesn.ylflGdyvdrGkqsletivlllaykikypenlfllrGnhesasinr

MYGFYGEVRSKYTNQMADLFQEVYNWLPLAQLINKKVMVMHGGLfSQDNVTIDDLRIIDRNRQPPESGLMCELLWSDPQPR-PGRSPSKRGVGIQFGPDV
.|||| |.. .|....   |..|.|.|||| |...|....|||| |..   ....| | |  . ||.||.|.||||||. .  | | ..||| ..||.||
iyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGl.spelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsftfgkdv

TKKFLEHNNLEYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFINLGADLKPNFKT
 .|||..|.|. |||.|.| .||||   . . .|||||||||....|.|| ... ..|. .|. 
vekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqi

subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 216-477 3.4e-64 209.9 In-house 31-290 (297) alignment
Range on Protein: 216-477
Range on HMM: 31-290/297.0
MLVQILAMFKKLPSLCDITIPegkkFTICGDIHGQFYDLLNIFEINGLPSEDNpYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMNQ
.|   | .||.  |. ..  |      .|||||||| ||| .|   | |   | ||| ||.|||| ||.| |. |. .|. .|  . | ||||| . .|.
lldlaldvfkaqksmvevnap....ikvcgdihgqfpdllrlfhrggwpptan.ylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecefvnk

MYGFYGEVRSKYTN-QMADLFQEVYNWLPLAQLINKKVMVMHGGLFS--QDNVTIDDLRIIDRNRQPPEsGLMCELLWSDPQP-RPGRSPSKRGVGIQFG
.|||| |.. .|   .|   ||.|.|||||. || .|...|||||     ...|.| || |.|...  | .|...|||.||     |    .|| |  ||
vygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierstegke.rlvadllwadpisglsgfmenqrgagcgfg

PDVTKKFLEHNNLEYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFINLGADLKPNFK
 |   |   . .|. ..|.|.| .||||.    | .|.|||| || |. |  ||.     |.  |.
rdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfe

subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 217-478 9.9e-66 214.8 In-house 17-273 (281) alignment
Range on Protein: 217-478
Range on HMM: 17-273/281.0
LVQILAMFKKLPSLCDITIPegkkFTICGDIHGQFYDLLNIFEINGLPSEDNpYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMNQM
. .. |.| .  .|..|  |     .. ||.|.|| || ..||. | ..|.  ..| ||.||||  |.||.. || .|. |.|.  | |||||  ..|..
ireveaifseekaLveidkP....ivvvGdlhaqfndlkrlfellgrvpeev.lvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvnki

YGFYGEVRSKYTNQMADLFQEVYNWLPLAQLINKKVMVMHGGLfSQDNVTIDDLRIIDRNRQPPESGLMCELLWSDPQPRP-GRSPSKRGVGIQFGPDVT
|||| |   ||  ..  |||. .| ||...||.|.|..||||| | . ...|.|| . .  .... ||. .|||.||...  .   | ||..  || .| 
ygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGl.sPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfGknvv

KKFLEHNNLEYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFINLGADLKPNFKT
..   . ..|.|.|.| |  |||||    | |||||.||||..  | .| . . ..|. ....
ddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislva

subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 220-485 2e-57 187.8 In-house 18-278 (280) alignment
Range on Protein: 220-485
Range on HMM: 18-278/280.0
ILAMFKKLPSLCDITIPegkkFTICGDIHGQFYDLLNIFEINGLPSEDNpYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMNQMYGF
. |.| .   ||.   |      . |||| |. |.  .|.. |   |..  .| ||.||||   .||.. || .|. | |. .| |||||. ..|..|||
veaifmeesnlceaeap....ikvigdihaqyqdmnrlfdligrvpeek.lmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiygf

YGEVRSKYTNQMADLFQEVYNWLPLAQLINKKVMVMHGGLfSQDNVTIDDLRIIDRNRQPPESGLMCELLWSDPQPR-PGRSPSKRGVGIQFGPDVTKKF
| |.. ||   .   || ..| .|.. ||.|.|..||||| | . . .| .| | |  .| . ||. .||||||  .  |   | ||.   ||  | .. 
yvecqykygvglwwdfqscfnrmpmsgliskrvlcmhggl.spelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkgvveqa

LEHNNLEYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFINLGADLKPNFKTYEAVPHP
 .  ... |.|.|.| .||||.    . ||||| |||| |. |  | . | |.|. .|.     | |
cksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlippplp

subfamily_PPZ_pd Subfamily PPZ 223-477 6.9e-56 182.9 In-house 40-289 (300) alignment
Range on Protein: 223-477
Range on HMM: 40-289/300.0
MFKKLPSLCDITIPegkkFTICGDIHGQFYDLLNIFEINGLPSEDNpYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMNQMYGFYGE
.|   |.| ... .      | ||.|||. ||| .|   |.|   | ||| ||.||||  |.| || |. .|. ||. | | |||||   . ..|||| |
lflaqpallelsps....vkivgdvhgqyadllrlftkcgfppsan.ylflgdyvdrgkqsletillllcykikypenffllrgnhecanvtrvygfyde

VRSKYTNQMADLFQEVYNWLPLAQLINKKVMVMHGGLFSQDNvTIDDLRIIDRNRQPPESGLMCELLWSDPQPRPGR-SPSKRGVGIQFGPDVTKKFLEH
.. .   ..   | . .| |||| ..  |....||||    | ..|..| . |  . |. ||. .||||||   .      .|||   .     .|||..
ckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvln.smdeirhvvrptdvpdfglindllwsdptdssnewednergvsycynkvainkflnk

NNLEYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFINLGADLKPNFK
  .. ..|.| | .||||.  |   .||||||||| .. | || ...   |  .|.
fgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfe

subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 229-468 2.5e-50 164.4 In-house 41-278 (307) alignment
Range on Protein: 229-468
Range on HMM: 41-278/307.0
SLCDITIPegkkFTICGDIHGQFYDLLNIFEINGLPSEDnPYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMNQMYGFYGEVR---S
.| ||  |      . ||.|||| ||.|.| . | | |   |.| ||.|||| .|.|.|| || .|. ||..  | |||||   .|. |||| |.     
alvdidpp....cvvvgdlhgqfndlinmfillgrppet.vyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygfyeecvtsip

KYTNQMADLFQEVYNWLPLAQLINKKVMVMHGGLfSQDNVTIDDLRIIDRNRQPPESGLMCELLWSDPQPRPG-RSPSKRGVGIQFGPDVTKKFLEHNNL
|  ...  ||| ..| ||.. ||  |...||||| |     .|.||   .  . |  |.. ..||.||.|       | || |. || .|         .
kcgeeiwalfqrcfnnlpisaliatkilcmhggl.spaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgtnviddvckrlgv

EYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFINL
| |.|.|..  ||| |    | ||.|||| ||.   | |. ...
eliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkv

subfamily_YNL217W_pd Subfamily YNL217W 237-365 1e-06 21.4 In-house 8-142 (235) alignment
Range on Protein: 237-365
Range on HMM: 8-142/235.0
EGKKFTICGDIHGQFYDLLNIFEINGLP-SEDNPYLFNGDFVDRGSFSVEVILTLfgfkllYPDHFHLSRGNHESDTMN------QMYGFYGEVRSKYTN
 ||.. . ||.|| . .|..... .     |.   .. ||....|  ||||.  .        |. .  .||||  ..       .  |.     |. ..
lgkrllvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllaykwvkkpkgaeplefsskfs

QM-ADLFQEVYNW---LPLA-QLINKKVMVMHGGLFSQDNV
 .  .| .. ...   |. . ..  ....|.|.|| ... .
flesklskadmeyarelgfsldipsdellvvhaGlvpgkfl

subfamily_PPP6C_pd Subfamily PPP6C 239-484 2e-73 240.1 In-house 42-286 (290) alignment
Range on Protein: 239-484
Range on HMM: 42-286/290.0
KKFTICGDIHGQFYDLLNIFEINGLPSeDNPYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMNQMYGFYGEVRSKYTNQMAD-LFQE
   |.|||||||||||...|   |    |. |.| ||||||| .|.| .  |. .|. |||.  | ||||||  . |.|||| |  .|| |  |   . .
spvtvcgdihgqfydleelfrtggqvp.dtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesrqitqvygfydeclnkygnanawkyctk

VYNWLPLAQLINKKVMVMHGGLfSQDNVTIDDLRIIDRNRQPPESGLMCELLWSDPQPRPGRSPSKRGVGIQFGPDVTKKFLEHNNLEYIVRSHEVKNDG
|.. |..| .|...|. .|||| | |  |.|..|.|.|... |. | .|.|.||||.     . |.|| |  ||  |||.|.. |||. |.|.|.. ..|
vfdlltiaaiideqvlcvhGgl.spdvktldqirvieraqeiphkgafcdlvwsdpedvetwavsprgagylfgskvtkefvhinnlklicrahqlveeg

YEVTHDGKCITVFSAPNYCDQIGNKGAFINLGADLKPNFKTYEAVPH
..   | | .||.|||||| . ||  . ..|  . . ..| ..|||.
lkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfkavpd

Metallophos Calcineurin-like phosphoesterase 240-434 3.1e-42 138.1 Pfam-A 2-199 (200) alignment
Range on Protein: 240-434
Range on HMM: 2-199/200.0
KFTICGDIHGQFYDL---LNIFEINGLPSEDNPYLFNGDFVDRGSFSVEVILTL--FGFKLLYPDHFHLSRGNHESDTMNQMYGFYGEVR----------
.....||.||...||   |.|.. .. ... ...||.||.||||  | |..  |  .  |||.|....| ||||||| .|. |||. |.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------SKYTNQMADLFQEVYNWLPLAQLINKKVMVMHGGLFSQDNVTIDDlriidrnrqppesglmcellwsdpqprpgrs
                         ....  .. ..|....|||. |...|. ..||.|.| .. . |                                
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

pskrgVGIQFGPDVTKKFLEHNNLEYIVRSHEVK
      .  ||||.. |.|| ... ...|.|. |
.....gselfgpdalekllekygvdlvlrGHtHk

subfamily_PPP4C_pd Subfamily PPP4C 241-483 1.4e-79 260.3 In-house 45-286 (288) alignment
Range on Protein: 241-483
Range on HMM: 45-286/288.0
FTICGDIHGQFYDLLNIFEINGLPsEDNPYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMNQMYGFYGEVRSKYTNQ-MADLFQEVY
 |.||||||||||||..|...|   ... ||| ||||||| .||| .| |  .|. |||. .| ||||||  . |.|||| |. .|| .. .  .  ||.
vtvcgdihgqfydllelfkvggdv.petnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrqitqvygfydeclrkygsanvwryctevf

NWLPLAQLINKKVMVMHGGLfSQDNVTIDDLRIIDRNRQPPESGLMCELLWSDPQPRPGRSPSKRGVGIQFGPDVTKKFLEHNNLEYIVRSHEVKNDGYE
..|.|| .|..|....|||| | .  |.|..|.|||... |..| .|.||||||.   | . | || |  || ||...| |.|..| |.|.|..  .|| 
dylslaaiidgkifcvhggl.spsistldeirsidrkqevphegplcdllwsdpedaegwavsprgagylfgsdvveqfneandielicrahqlvmegyk

VTHDGKCITVFSAPNYCDQIGNKGAFINLGADLKPNFKTYEAVP
.  . | .||.|||||| . ||. | ..| ..|. .|| .||..
lhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaaa

subfamily_PPP2C_pd Subfamily PPP2C 241-484 2.6e-78 256.1 In-house 46-288 (290) alignment
Range on Protein: 241-484
Range on HMM: 46-288/290.0
FTICGDIHGQFYDLLNIFEINGlPSEDNPYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMNQMYGFYGEVRSKYTNQ-MADLFQEVY
 |.|||.||||.|||..| | |  | |  ||| ||.|||| .||| .  |  .|. |..   . ||||||  . |.||||.|.  ||.|  .  .| ...
vtvcgdvhgqfhdllelfkigg.kspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhesrqitqvygfydeclrkygnanvwkyftdlf

NWLPLAQLINKKVMVMHGGLfSQDNVTIDDLRIIDRNRQPPESGLMCELLWSDPQPRPGRSPSKRGVGIQFGPDVTKKFLEHNNLEYIVRSHEVKNDGYE
..|||. |........|||| |    |.|..| .|| .. |. | .|.||||||. | | . |.|| | .|| |...|| ..|.|..|.|.|..  .||.
dylpltalvdeqifclhggl.spsidtldkiraldrlqevphegplcdllwsdpddrggwgisprgagytfgkdisekfnktngltliarahqlvmegyn

VTHDGKCITVFSAPNYCDQIGNKGAFINLGADLKPNFKTYEAVPH
..|| . .|.||||||| . ||..| ..|  .|| .| .... |.
wshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpapr

subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 241-478 7.7e-74 241.7 In-house 37-279 (284) alignment
Range on Protein: 241-478
Range on HMM: 37-279/284.0
FTICGDIHGQFYDLLNIFEINGLP-----SEDNPYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMNQMYGFYGEVRSKYTNQMADLF
 .|.||||||| ||| ....|| |     .... ||| ||.|||| ||.|||. || .|||.||.  | ||||||  .|. |||| | . .|.... . |
vkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrgnhesrpvnmqygfyleckkrysealyeaf

QEVYNWLPLAQLINKKVMVMHGGLfSQDNVTIDDLRIIDRNRQPPESGLMCELLWSDPQPR-PGRSPSKRGVGIQFGPDVTKKFLEHNNLEYIVRSHEVK
|  .| .||. ...||.. ||||. |.| . ...|  ..|  . |. |....| |.||. .  |   |.|| |  ||..  |.||.. .|. .||.|.| 
qlafnamplcavvskkiicmhggi.sedlldlkqldklerpidipdigviadltwadpeaevegykesprgagkvfgakavkeflkkfkldlvvrahqvv

NDGYEVTHDGKCITVFSAPNYCDQIGNKGAFINLGADLKPNFKT
 ||||   | | .|.|||| || |. | .| .|.  .|   |..
mdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftv

subfamily_PPG1_pd Subfamily PPG1 241-484 9.1e-72 234.8 In-house 43-298 (300) alignment
Range on Protein: 241-484
Range on HMM: 43-298/300.0
FTICGDIHGQFYDLLNIFEINGlPSEDNPYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMNQMYGFYGEVRSKY--TNQMADLFQEV
 |. ||.||||||.|.||.| | .  |  ||| ||.|||| .||| |  |  .|| ||   .| ||||||  . |.||||.|.  ||   ... . . |.
vtvvgdvhgqfydvleifkigg.qvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrqitqvygfyteclrkyggnsrvwkyltei

YNWLPLAQLINKKVMVMHGGLfSQDNVTIDDLRIIDRNRQPPESGLMCELLWSDPQ-------PRPGRSP-----SKRGVGIQFGPDVTKKFLEHNNLEY
...| || .|.......|||| | .  .||.....|| |. |. | ...||||||.        .| |.      |.|| |  .| ||..|||. |... 
fdylvlaaiideeiycvhggl.spsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqhfvvsqrgagysygkdvvekflrnndmnr

IVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFINLGADLKPNFKTYEAVPH
|.|.|.. |.||..  |.|  ||.|||||| . ||| . ..|   ..  |..||. |.
iirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeeape

subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 241-477 1.5e-69 227.3 In-house 35-270 (280) alignment
Range on Protein: 241-477
Range on HMM: 35-270/280.0
FTICGDIHGQFYDLLNIFEINGLPSEDNpYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMNQMYGFYGEVRSKYTNQMADLFQEVYN
 ..|||.|||. ||| .|.  ..| ..| ||| ||.||||.. .|||| |. .|. ||..| . |||||  ..|. |||. ||. .|.... . |||...
vavcgdlhgqytdllrlfarvsfppdqn.ylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisinrkygfkdevkrryslalynefqelld

WLPLAQLINKKVMVMHGGLfSQDNVTIDDLRIIDRNRQPPESGLMCELLWSDPQ-PRPGRSPSKRGVGIQFGPDVTKKFLEHNNLEYIVRSHEVKNDGYE
 |||. |.. ....||||| ||. |..|||. . |  ..... |  .|||.||.    | . . ||| ..|| .| |.. |. ... |.| |.| .||||
slplvalvsgrilcmhggl.sqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifganvvkdltekldidliarghqvvqdgye

VTHDGKCITVFSAPNYCDQIGNKGAFINLGADLKPNFK
   | | .||||||.|.... |. | . . . |.  |.
ffadkklvtvfsapkylgefdnsaavlivderlivsfe

subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 241-467 3.5e-45 147.7 In-house 9-241 (263) alignment
Range on Protein: 241-467
Range on HMM: 9-241/263.0
FTICGDIHGQFYDLLNIFEINGLPSeDNPYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMNQMYGFYGEVRSKYTN-----QMADLF
  |||| |||. ||| ||.  |  .    ||| ||.|||| .|.|||. || .||  | ..|| |||||  ..|. |||. |.. ..        . . |
inicgdthgqyndllrifnacgaat.ktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesvynhf

QEVYNWLPLAQLINKKVMVMHGGLfSQDNVTIDDLRIIDRNRQPP-ESGLMCELLWSDPQP-RPGRSPSK-RGVGIQFGPDVTKKFLEHNNLEYIVRSHE
..|....||. ...|....||||. |    ..||.| |    .      | |.|||.||.    |  | | | .   ||      . .. ... |||.|.
nqvfsymplcaivskrilcmhggi.sphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidlivrahq

VKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFIN
| . || .  | . ||||||  |  .. |  | . 
vveygyaffadrrlitvfsasryqielcnyaavvv

subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 241-267 9.5e-08 24.5 In-house 38-65 (317) alignment
Range on Protein: 241-267
Range on HMM: 38-65/317.0
FTICGDIHGQFYDLLNIFEINGLP-SED
 ||.||||||| ||| ....|| | |..
vtivGdihGqfedllalldlnGwplssq

PPP_4 242-434 1.8e-75 246.3 In-house 2-197 (197) alignment
Range on Protein: 242-434
Range on HMM: 2-197/197.0
TICGDIHGQFYDL-LNIFEINGLPSEDNPYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMNQMYGFYGEVRSKYTNQMADLFQEVYN
|..||||||..|| |..... |||||.. |.|.||.||||..|.||.|.|. .|| ||....| ||||||  .|..|||. || .|..... . .|.|..
tvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvfd

WLPLAQLINKKVMVMHGGLFSQDNvTIDDLRIIDRNRQPP-ESGLMCEL-LWSDPQ-PRPGRSPSKRGVGIQFGPDVTKKFLEHNNLEYIVRSHEVK
.||||.||..||.|.||||... . ..|... |.|... | |......| |||||.    | ..|.||.|. ||||||.||||.|||..|.||||.|
llplaalidekvlvvhgglsdele.sldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshelk

PPP_2 242-434 6.1e-74 241.0 In-house 2-198 (198) alignment
Range on Protein: 242-434
Range on HMM: 2-198/198.0
TICGDIHGQFYDLlNIFEINGLPSEDNPYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMNQMYGFYGEVR-SKYTNQMADLFQEVYN
|.|||.|||..|| .|.  |||||... |||.||.||||..|.||.|.|. .|| ||...|| ||||||...|..|||. ||  .|..... . .|||..
tvcGDlHGqldDL.lilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

WLPLAQLINKKVMVMHGGLFSQDNvTIDDLRIIDRNRQPPESGLMCEL-----LWSDPQPRPGRSPSKRGVGIQFGPDVTKKFLEHNNLEYIVRSHEVK
.||||.||..||.|.||||... . ..|. . ..|... ||.|....|     |..... . . ..|.||.|. ||||||...||.|.|..|.|.||||
lLplaalidekvlvvHGGlseeik.lldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHevk

PPP_5_Dcr2 242-434 5.9e-73 238.1 In-house 2-199 (199) alignment
Range on Protein: 242-434
Range on HMM: 2-199/199.0
TICGDIHGQFYDLLNIFEING-LPSEDNPYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMNQMYGFYGEVRSK-YTNQMADLFQEVY
|.|||.|||..||| |.. .| .|||.. |.|.||.||||..|.||.|.|. .||.||...|| |||||.  .|..|||. || || . ... . ...|.
tvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdvf

NWLPLAQLINKKVMVMHGGLFSQDNvTIDDLRIIDRNRQPP-ESGLMCEL-LWSDPQ-PRPG-RSPSKRGVGIQFGPDVTKKFLEHNNLEYIVRSHEVK
.|||||.||..||.|.||||... . .|..|. |.|... | |.| ...| |||||.    |   .|.||.|. ||||||.||||.|||..|.||||.|
dwlPlaalidekvlvvhgglspeik.siellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk

subfamily_PPPLV_pd Subfamily PPPLV 243-466 2.5e-41 134.9 In-house 28-273 (290) alignment
Range on Protein: 243-466
Range on HMM: 28-273/290.0
ICGDIHGQFYDLLNI---FEINGLPSEDNPYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMNQMYGFYGEVRSKYTNQMADL---FQ
. ||.||.. ||  .   .   |       .|| ||.|||| ||||.|  |.  |.||| ...| ||||| ... . . ..||   |. ... .    |.
vlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqesieykgegsfkfgdsleevweafn

EVYNWLPLAQLINKKVMVMHGGLFSQ--DNVTID-DLRIIDRNRQPPE-SGLMCELLWSDPQPRP------------G-RSPSKRGVGIQFGPDVTKKFL
.|...||||  |..||. .|.|.      .  |     |..| ... . . |  ..|||||.               |  . ..|| |  |. |  ..||
nvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvlneGfvdndrrGtghvfsedaleafl

EHNNLEYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQiGNKGAFI
..|||....|.||||. |... ..|. .||||. .|| .  |. | |
krnnlsfvlrahevkekGirlqqkgrlltvfsssrycGs.sneaali

subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 269-479 2.1e-67 220.6 In-house 102-312 (317) alignment
Range on Protein: 269-479
Range on HMM: 102-312/317.0
PYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMNQMYGFYGEVRSKYTNQMADLFQEVYNWLPLAQLINKKVMVMHGGLfSQDNVTID
 ||| ||.|||| ||.||.. || .||||||. .| |||||| ..|. |||| ||. .| ... . || ..| |||. ..|||.. ||||. |.. . ..
kylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGi.seelldlk

DLRIIDRNRQPPESGLMCELLWSDPQPR-PGRSPSKRGVGIQFGPDVTKKFLEHNNLEYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFIN
 |  ..|  . |. |....| |.||...  |  .|.|| |  ||..  |.||.. .|. .||.|.| .||||   | | .|.||||.|| |. | .| ..
qldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavls

LGADLKPNFKTY
.  .||  ....
vdkklkisinvl

subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 269-474 5.9e-55 179.7 In-house 121-326 (339) alignment
Range on Protein: 269-474
Range on HMM: 121-326/339.0
PYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMNQMYGFYGEVRSKYTNQMADLFQEVYNWLPLAQLINKKVMVMHGGLfSQDNVTID
 ||| ||.|||| ||.||.. |  .|| |||. .| |||||| ..|  |||| ||  .|  |. . ||...| .|.. .||. .|.||||. |.   ...
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggi.sehltsfn

DLRIIDRNRQPPESGLMCELLWSDPQPR-PGRSPSKRGVGIQFGPDVTKKFLEHNNLEYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFIN
.. .. |  . |. |.. .| |.||.|   |  || ||  . |||   . ||.. .|. ..| |.| .||||.    . .|.||||||| |  |  | . 
qfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfs

LGADLKP
.   || 
idkklki

subfamily_PPP7C_pd Subfamily PPP7C 385-482 1.1e-33 109.5 In-house 237-335 (383) alignment
Range on Protein: 385-482
Range on HMM: 237-335/383.0
MCELLWSDPQPRPGRSPS-KRGVGIQFGPDVTKKFLEHNNLEYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFINLGADLKPNFKTYEAV
. ..|||||. . |  |   || |. ||||||||.|.. ||....|||| | .|||..|| |..|.||| || ..  |.||...|| ||.|..  | | 
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqyqas