Gene PPP5C in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP5C
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP157_AA protein Get Run
SpurP157_AA_187-496 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
TPR_12 Tetratricopeptide repeat 25-61 5.5e-08 22.1 Pfam-A 40-76 (78) alignment 
Range on Protein: 25-61
Range on HMM: 40-76/78.0
EVDREKAEALKDKANTYFKAQDFQQAITYYSEALEIN
. . . | || . ||.| ...|...|. |. .|||| 
ddhpdtaralnnlanlylalgdydeAleylekAleia
RPN7 26S proteasome subunit RPN7 25-127 2e-07 17.0 Pfam-A 30-134 (177) alignment 
Range on Protein: 25-127
Range on HMM: 30-134/177.0
EVDREKAEALKDKANTYFKAQDFQQAITYYSEALEiNPTVAAFHGNRSFAYLKTECFGSALEDASKALELDKSYIKG---YYRRATANMALGKIKIALKD
... . ..||.|.|. |.|. |...|. .||.|..   | .  . .  .. .... |    . .|| ||  ||...      ||.  ... | ...| ..
likesirraledlaehYlkigdleeAlkaysrard.yctslkhkidmllnvirvsiffndwslvskylekaksllekggdwerrnrlkvyeGlaalanrk

YEMVVK
.. ...
fkeaae
TPR_11 TPR repeat 29-96 3.5e-21 64.3 Pfam-A 1-69 (69) alignment 
Range on Protein: 29-96
Range on HMM: 1-69/69.0
EKAEALKDKANTYFKAQDFQQAITYYSEALEINPTVAAFHGNRSFAYLKTE-CFGSALEDASKALELDK
|.||||| ..| .||..|...|| .|..|||..|  |  . |.. ||||    . .||||..||||||.
enAealkelGnalfkegdydeAieayekAleldpnnaelyynlAlaylklgkdyeeAledyekAleldP
TPR_1 Tetratricopeptide repeat 31-63 9.4e-13 36.9 Pfam-A 1-33 (34) alignment 
Range on Protein: 31-63
Range on HMM: 1-33/34.0
AEALKDKANTYFKAQDFQQAITYYSEALEINPT
|.||. ..|.|.| .....|. ||..|||.||.
akalynlGnaylklgkydeAleyyekALelnPn
TPR_2 Tetratricopeptide repeat 31-63 2.2e-10 29.5 Pfam-A 1-33 (34) alignment 
Range on Protein: 31-63
Range on HMM: 1-33/34.0
AEALKDKANTYFKAQDFQQAITYYSEALEINPT
||||   .. |.|..|...|. .. .|||..|.
aealynlGlayyklgdyeeAleafekAleldPn
TPR_14 Tetratricopeptide repeat 31-68 2.3e-06 17.7 Pfam-A 1-38 (44) alignment 
Range on Protein: 31-68
Range on HMM: 1-38/44.0
AEALKDKANTYFKAQDFQQAITYYSEALEINPTVAAFH
.||| . |. .. ..|...|| .. .||. .|. |...
peallalarallalGdpdeAiallrralalaPddaeal
TPR_8 Tetratricopeptide repeat 33-62 6.1e-06 15.4 Pfam-A 3-32 (34) alignment 
Range on Protein: 33-62
Range on HMM: 3-32/34.0
ALKDKANTYFKAQDFQQAITYYSEALEINP
|.  .. .|..  |. .|. |. .|||..|
ayynlGdiYrqlGdydkAkeylekalelkp
TPR_16 Tetratricopeptide repeat 36-78 5.6e-06 16.6 Pfam-A 2-44 (65) alignment 
Range on Protein: 36-78
Range on HMM: 2-44/65.0
DKANTYFKAQDFQQAITYYSEALEINPTVAAFHGNRSFAYLKT
..|. ...|.|...|. ....||. .|  | .. ..  |.|. 
alArallraGdydeAlaaleaalalaPeaaeallllaeallrq
TPR_7 Tetratricopeptide repeat 38-60 9.3e-07 17.5 Pfam-A 6-30 (36) alignment 
Range on Protein: 38-60
Range on HMM: 6-30/36.0
ANTYFKAQDFQQAITYYSEAL--EI
|..|.. .|...||..| .||  . 
arlysrlgdyekAielyeraLaltk
TPR_9 Tetratricopeptide repeat 39-96 2.7e-07 19.8 Pfam-A 3-60 (73) alignment 
Range on Protein: 39-96
Range on HMM: 3-60/73.0
NTYFKAQDFQQAITYYSEALEINPTVAAFHGNRSFAYLKTECFGSALEDASKALELDK
..|. ..||..|. ..   |...|  .  .  | ... ...|.  |||| . .|||..
aiylreedferALavverllllaPddpyerRDrGlllaqlgclaaAledLeaflelcp
TPR_11 TPR repeat 84-130 1e-09 27.5 Pfam-A 22-69 (69) alignment 
Range on Protein: 84-130
Range on HMM: 22-69/69.0
ALEDASKALELDKSYIKGYYRRATANMALGK-IKIALKDYEMVVKYRP
|.|  .||||||... . ||..| | . |||  . ||.|||......|
AieayekAleldpnnaelyynlAlaylklgkdyeeAledyekAleldP
TPR_1 Tetratricopeptide repeat 100-132 1.2e-07 20.8 Pfam-A 2-34 (34) alignment 
Range on Protein: 100-132
Range on HMM: 2-34/34.0
KGYYRRATANMALGKIKIALKDYEMVVKYRPND
| .|... | . ||| . ||..|| ... .||.
kalynlGnaylklgkydeAleyyekALelnPnn
TPR_2 Tetratricopeptide repeat 100-132 7e-06 15.5 Pfam-A 2-34 (34) alignment 
Range on Protein: 100-132
Range on HMM: 2-34/34.0
KGYYRRATANMALGKIKIALKDYEMVVKYRPND
...|... | ..||. . ||...| .... ||.
ealynlGlayyklgdyeeAleafekAleldPnn
PPP5 PPP5 TPR repeat region 138-233 9.2e-35 109.0 Pfam-A 1-95 (95) alignment 
Range on Protein: 138-233
Range on HMM: 1-95/95.0
KYTECSKLVKQQAFERAIRGhTEEKKSVIDTINLENMIIEGDYEGPALENDKVTKDFMVKLLQHFKDEKALHRKFAYTMLVQILAMFKKLPSLCDI
|..||.||||..|||.||    |||.|| ..|..|.. || ||.|| ||..|||..|. .||..||..| ||.||.|..|...  ..|||||| .|
KlkeCeklvkkiaFekAIev.deekrsvaesidiesieieddYdgprledekvtlefvkelleefkkqkklhkkfvyqilldvkellkklpslvei
subfamily_PPP5C_pd Subfamily PPP5C 176-495 1.1e-184 605.8 In-house 2-322 (322) alignment 
Range on Protein: 176-495
Range on HMM: 2-322/322.0
IEGDYEGPALENDKVTKDFMVKLLQHFKDEKALHRKFAYTMLVQILAMFKKLPSLCDITIPEGKKFTICGDIHGQFYDLLNIFEINGLPSEDNPYLFNGD
.| .|.|| ||..|.||.|. .||..||..|.||.|.|...|... ...||||||..|||.|.||.|.||||||||||||||||.||||||.||||||||
vedsydgpkleeekitkefvkellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGd

FVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMNQMYGFYGEVRSKYTNQMADLFQEVYNWLPLAQLINKKVMVMHGGLFSQDNVTIDDLRIIDR
|||||||||||||||.|||||||.||.|||||||||.||..||| |||..|||...||||.||.||||||..||.||.|.||||||.|.||.|||| |||
fvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidr

NRQPPESGLMCELLWSDPQPRPGRSPSKRGVGIQFGPDVTKKFLEHNNLEYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFINL-GADLKP
|.||||.||..||||||||...||||||||||.|||||||||||..||||.|.||||||..||||.||||.||||||||||||.|||||||.| |.|||.
naqppeegllvellwsdpqeanGrspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlkl

NFKTYEAVPHPNVRPMAYANS
.|||.|||.||.|.|||||||
kfktfeavehpdvkpmayans
subfamily_PPP7C_pd Subfamily PPP7C 176-377 3.5e-62 203.3 In-house 2-203 (383) alignment 
Range on Protein: 176-377
Range on HMM: 2-203/383.0
IEGDYEGPALENdKVTKDFMVKLLQHFKDEKALHRKFAYTMLVQILAMFKKLPSLCDITIPEGKKFTICGDIHGQFYDLLNIFEINGLPSEDNPYLFNGD
.| .|.|| |.   .||| . ||...|| .| || |.  ..| .   ..|.||..  ..    |. |.|||.||.. ||| |.  ||||||.|||.||||
vedsytgprlsl.pltkdeveklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGd

FVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMNQMYGFYGEVRSKY---TNQMADLFQEVYNWLPLAQLINKKVMVMHGGLFsqDNVTIDDLRI
|||||. |||..| |. . |.|| ...| |||||   .|  |||  || |||   ....  |...|. ||||| ||..|....|||.   |.  .. |  
fvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGis..dktdlelldk

IDRNR
|.|..
iersk
0045823 Metallo-dependent phosphatases 188-496 1.4e-105 346.6 In-house 23-338 (473) alignment 
Range on Protein: 188-496
Range on HMM: 23-338/473.0
DKVTKDFMVKLLQHFKDEKALHRKFAYTMLVQILAMFKKLPSLCDITIpegkKFTICGDIHGQFYDLLNIFEINGLPSEdNPYLFNGDFVDRGSFSVEVI
. ... .. .|..|.| |. |. .... .| ..  ..|| |.| ...     .....||||||..|||...|..|.|.| . ..|.||.||||..|.||.
illglldldlliehlkkegllpeedllklldeakeilkkepnllelsm....rivviGDiHGqlddLlrllekigfppe.drlvflGDlvDrGpdslevl

LTLFGFKLLYPDHFHLSRGNHESDTMNQMYGFYGEVRSKYTNQMADLFQEVYNWLPLAQLINKKVMVMHGGLFSQDnVTIDDLRIIDRNRQPPESGLMCE
. |. .|..||....| |||||.  .|..|||..|.. ||. .. . |.|. ..|||| .|..|. ..||||...   ..|..| |.| ...|..||...
elllalkikypgnvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdl.plldqireierpleipddgllld

LLWSDPQPRPG--------RSPSKRGVGIQFGPDVTKKFLEHNNLEYIVRSHEVKNDGYEVTHDGK------CITVFSAPNYCDQIGNKGAFINLGADLk
||||||..  |        . .|.||.| .||||....||..|.| .|||.|..  .|||...|||      .||||||||||.. ||..|.. .. || 
llwsdPweddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.

PNFKTYEAVPHPNVRPMAYANSM
..|......|||...|... . .
isfiqfdpsphplilplfldvfl
0049330 Metallo-dependent phosphatases 189-488 4.5e-95 311.2 In-house 11-305 (309) alignment 
Range on Protein: 189-488
Range on HMM: 11-305/309.0
KVTKDFMVKLLQHFKDEKALHRKFAYTMLVQILAMFKKLPSLCDITipegKKFTICGDIHGQFYDLLNIFEINGLPSEdNPYLFNGDFVDRGSFSVEVIL
....... .|..... .| |. ......| ..  ..|. |.| ...     .....||||||..|||...|..|.|.| . ..|.||.||||..|.||.|
elilslldllielllklkllseeellllllkakeilksepnllels....mrivviGDiHGqlddLlrllekigfppe.drlvflGDlvdrGpdslevll

TLFGFKLLYPDHFHLSRGNHESDTMNQMYGFYGEVRSKYTNQMADLFQEVYNWLPLAQLINKKVMVMHGGLFSQDnVTIDDLRIIDRNRQPPESGLMCEL
.|. .||||||...| |||||.  .|..|||..|.  ||  .. . |......|||| .|..|....||||...  ...|..| ..| ...|. ||.|.|
lllalkllypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdl.llldqirelerpleipldgllcdl

LWSDPQ-PRPGRSPSKRGVGIQFGPDVTKKFLEHNNLEYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFINLGADLKPNFKTYEAVPHPNV
|||||.  |.|  |..||.|. ||......||..|.|..|.|.|..  .||.. .|||.||||||||||...||.||.. .. ||...|...|.||.. .
lwsdplpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpllll

R
 
l
0053225 Metallo-dependent phosphatases 193-483 6.3e-88 287.9 In-house 7-292 (293) alignment 
Range on Protein: 193-483
Range on HMM: 7-292/293.0
DFMVKLLQHFKDEKALHRKFAYTMLVQILAMFKKLPSLCDITipegKKFTICGDIHGQFYDLLNIFEINGLPSEdNPYLFNGDFVDRGSFSVEVILTLFG
 .. .|.....  | |. ......| ..  ..|| |.| ...     .....|||||...|||...|. |.|.| . ..|.||.||||..|.||.. |. 
llldllielllllkllseeelllllleakeilkkepnllels....mriyviGDiHGnlddLlallekigfppe.drlvflGDlvdrGpdslevlellla

FKLLYPDHFHLSRGNHESDTMNQMYGFYGEVRSKY-TNQMADLFQEVYNWLPLAQLINKKVMVMHGGLfSQDNVTIDDLRIIDRNRQPPESGLMCELLWS
.||||||...| |||||.  .|..|||..|.  ||   .. | .......|||| ||..|....|||| | | ...|..| |.|  ..|. ||...||||
lkllypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGl.spdlslldqireinrplriplegllldllws

DPQPRPGRSPSKRGVGIQFGPDVTKKFLEHNNLEYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFINLGADLKPNFKTYEAVP
||. . |  ||.||.|. ||......||..|.|..|.|.|.|  |||.. .|||..||||||||... ||.||.. |. .|...||....|.
dpdlwsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapvl
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 193-479 1.6e-80 263.3 In-house 5-291 (298) alignment 
Range on Protein: 193-479
Range on HMM: 5-291/298.0
DFMVKLLQHFKDEKALHRKFAYTMLVQIL----AMFKKLPSLCDITIPegkkFTICGDIHGQFYDLLNIFEINGLPSEDNpYLFNGDFVDRGSFSVEVIL
......|.  . || | ..   . . ...     .||| .|| ..  |     ..|||||||. ||| .|. .| | . | ||| ||.||||....|||.
ellievlsvslsekkltkvikeedveklielakkifkkqkslvevdap....ikvcGdihGqysdllrlfdkagfppdan.ylflGdyvdrGrqnleviv

TLFGFKLLYPDHFHLSRGNHESDTMNQMYGFYGEVRSKY-TNQMADLFQEVYNWLPLAQLINKKVMVMHGGLfSQDNVTIDDLRIIDRNRQPPESGLMCE
 |. .|. ||..| | |||||  ..|..|||| |.. .|   ..   ||.|.|.|||. || .... ||||| |.  ...|.|| . |  ...|. |  .
lllaykvkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGl.skklksldqlrelkrpfdskeeslaid

LLWSDPQP-RPGRSPSKRGVGIQFGPDVTKKFLEHNNLEYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFINLGADLKPNFKTY
|||.||.    | ....|||...|| || |..||. ... .||.| | .||||   . | .|.||||.||.|  |  |.... ..|.  |. .
llwadpenavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevl
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 193-483 1e-68 224.8 In-house 5-295 (299) alignment 
Range on Protein: 193-483
Range on HMM: 5-295/299.0
DFMVKLLQHFKDEKALHRKFAYTMLVQILAMFKKLPSLCDITIPEGKKFTICGDIHGQFYDLLNIFEINGLPSEDNpYLFNGDFVDRGSFSVEVILTLFG
....|||.  . || | .      |... |. |.        .       .|||||||. ||| ||...|.| . | .|| ||.||||   .|.|  |. 
ellskllnvgmsekrltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvn.flflgdyvdrgrqnlelitlllc

FKLLYPDHFHLSRGNHESDTMNQMYGFYGEVRSKYTN-QMADLFQEVYNWLPLAQLINKKVMVMHGGLfSQDNVTIDDLRIIDRNRQPPESGLMCELLWS
||. ||..|.. |||||  ..|..|||| |.  .|.  ..  .||. ....||. ||. ....||||| |    |.| || . | ..||.  |  .|||.
fkikyperffmlrgnhecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhggl.spklqtldqlrdltrpqdppnpslgidllwa

DPQP-RPGRSPSKRGVGIQFGPDVTKKFLEHNNLEYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFINLGADLKPNFKTYEAVP
||.    .  .  |||   ||.|| .. ... ... . |.|.| .||||   . | .|.|||| || |. |  | ...  .|   |. ..  |
dpdqsvkdwlanvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptp
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 195-476 6.7e-63 205.4 In-house 3-283 (290) alignment 
Range on Protein: 195-476
Range on HMM: 3-283/290.0
MVKLLQHFKDEKALHRKFAYTMLVQILAMFKKLPSLCDITIPegkkFTICGDIHGQFYDLLNIFEINGLPSeDNPYLFNGDFVDRGSFSVEVILTLFGFK
|.. |...   .|.  |  ...| .|  ... ||.| ..  |     .| ||||||. .||. |.  | |  .  .|| ||.||||. |.|| | || .|
miehllkygvldafsdkdileilekieeileplpalleveap....ivivgdihgqldallryfdavgypp.kvkflflgdyvdrgakslevslllfcyk

LLYPDHFHLSRGNHESDTMNQMYGFYGEVRSKYTNQMADLFQEVYNWLPLAQLINKKVMVMHGGLfSQDNVTIDDLRIIDRNRQP--PESGLMCELLWSD
..|. . || |||||   .|..|||. |.  | ....   .|.|.. |.|   ...|.. ||||. ||.  . . |. . . | |   . ||. .|||.|
iryskkvhllrgnhevrkvnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggi.sqkiesweslkalkkprvpltcdeglqvdllwad

PQP---RPGRSPSKRGVGIQFGPDVTKKFLEHNNLEYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFINLGADLKPNF
|.       .   .|.. . || ..  ..|..  |. |||.||||..|..   | |..|||||| |. .  | || ...   |. ..
ptrdkddtialnkqraisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsi
subfamily_PPP3C_pd Subfamily PPP3C 196-489 5.2e-78 255.8 In-house 29-329 (452) alignment 
Range on Protein: 196-489
Range on HMM: 29-329/452.0
VKLLQHFKDEKALHRKFAYTMLVQILAMFKKLPSLCDITIPegkkFTICGDIHGQFYDLLNIFEINGLPSEDNpYLFNGDFVDRGSFSVEVILTLFGFKL
  | .||. |  |... |  .. .  ...|| ..| ..  |     |..|||||||||||..||..| |.. . ||| ||.||||.||.|..| |.  |.
evlkehflkegrleeeaalkiieeaakllkkektlleveaP....itviGdihGqfydllklfevgGdPastk.ylflGdyvdrGyfsiecvlylyalki

LYPDHFHLSRGNHESDTMNQMYGFYGEVRSKYTNQMADLFQEVYNWLPLAQLINKKVMVMHGGLfSQDNVTIDDLRIIDRNRQPPESGLMCELLWSDPQP
 ||....| |||||.  . . . |  |...||.... | . | .. |||| |.|.. . .|||| | .  ..||.. .|| ..||.||..|.||||||  
aypstlfllrGnhecrhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGl.speikslddikkldrfkeppasGplcdllWsdPle

RPGRSP--------SKRGVGIQFGPDVTKKFLEHNNLEYIVRSHEVKNDGYEVTHD------GKCITVFSAPNYCDQIGNKGAFINLGADlKPNFKTYEA
. | .         | ||  . ..   . .||..|.|  |.|.||....||.. ..         ||.||||||.|   ||.| ...  . . | . ...
dygeekteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyenn.vmnirqfns

VPHPNVRP
.|||   |
sphpywlp
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 206-475 7.9e-68 221.4 In-house 8-275 (287) alignment 
Range on Protein: 206-475
Range on HMM: 8-275/287.0
KALHRKFAYTMLVQILAMFKKLPSLCDITIPegkkFTICGDIHGQFYDLLNIFEINGLPSeDNPYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSR
.|.  |  ...| .|  ... ||.| ... |     ||.||||||. |||.||.  | .. .  ||| ||.||||. |.||.| || .|..|| . || |
dafsdkdilevlekieeileplpalleveap....itivGdihGqlddllrifnavGaap.kvqylflGdyvdrGakslevslllfslkiaypkkvhllr

GNHESDTMNQMYGFYGEVRSKYTNQMADLFQEVYNWLPLAQLINKKVMVMHGGLfSQDNVTIDDLRIIDRNRQPPES--GLMCELLWSDPQPRP-GRSP-
||||   .|..|||. |.. |. ...   |..|.. |||   ..|... ||||. |..  ..|.|. . . ..| .   ||. .|||.||.    .  . 
GnhevkkinklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGi.spklksldslkalkkpttplacdeglqvdllwadpekdaktfeln

SKRGVGIQFGPDVTKKFLEHNNLEYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFINLGADLKPN
  |..   ||  .  ..|.. ... |||.|||...||.   | ...|||||| |. .  | || . .   |. .
kiraisvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslels
PP2Ac_SM00156 209-481 1.3e-103 338.8 In-house 2-269 (271) alignment 
Range on Protein: 209-481
Range on HMM: 2-269/271.0
HRKFAYTMLVQILAMFKKLPSLCDITipegKKFTICGDIHGQFYDLLNIFEINGlPSEDNPYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNH
... ....| .. ...|. ..|....    .. |..||||||..|||...| .| ......|.|.||.||||..|.||||.|| .|.|||....| ||||
skeevlelleevkeilkqeknlvevs....apvtvvGdihGqlddllrllelag.eppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnH

ESDTMNQMYGFYGEVRSKYTNQMADLFQEVYNWLPLAQLINKKVMVMHGGLFSqDNVTIDDLRIIDRNRQPPESGLMCELLWSDP-QPRPGRSPSKRGVG
||. .|..|||. ||. ||.... . |.|....|||| |...|...||||| . .  ..||.| ..|....||.||...|||||| |. .| .|||||..
EsssvnkiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlsp.eleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrgls

IQFGPDVTKKFLEHNNLEYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFINLGADLKPNFKTYEA
..||.|..|.||..|||..|.|.|||...|||. .|.|..|.||||||||. .||.|....  .||........
vvFgedavkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlke
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 214-472 4.2e-63 206.4 In-house 9-264 (284) alignment 
Range on Protein: 214-472
Range on HMM: 9-264/284.0
YTMLVQILAMFKKLPSLCDITIPegkkFTICGDIHGQFYDLLNIFEINGLPSEDNpYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTM
 |.|.. ...|.| | | ..  |      ||||||||| ||| .|. ||.|   | ||| ||.||||   .| || || .|...|.|| . |||||   .
etllfhafsifnkqpmlievnsp....inicgdihgqfsdllrlfdkngfphran.ylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecsli

NQMYGFYGEVRSKYTNQ-MADLFQEVYNWLPLAQLINKKVMVMHGGLfSQDNVTIDDLRIIDRNRQPPES-GLMCELLWSDPQP-RPGRSPSKRGVGIQF
|..|||| |.. .| .  .   |. |.  .||. |. .....||||. |.    . .|| | |  . ||   |  ..|||||   . |  |  |||   |
nkiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggv.skmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvf

GPDVTKKFLEHNNLEYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFINLGADL
| |  .|.|.. ... .||.|.| .||||.  . . .|.|||| || |. |  | . .  .|
gsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknl
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 214-471 7.1e-44 143.2 In-house 12-289 (302) alignment 
Range on Protein: 214-471
Range on HMM: 12-289/302.0
YTMLVQILAMFKKLPSLCDITIPegkkFTICGDIHGQFYDLLNIFEINGLPSE----------DNPYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHL
.... .. ...||  .| .|. |     || ||||||| ||. |.  .    |           . ..| ||.||||| |.| |  .| .|.||| .. |
lllieaviellkkektlaeispP....vtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyil

SRGNHESDTMNQMYGFYGEVRSKYTN----QMADLFQEVYNWLPLAQLINKKVMVMHGGLfSQDNVTIDDLRIIDRNRQP-PESGLMCELLWSDPQPR--
 |||||. ..|  ||| .|.  ....    .. . |.||. ..||| |. .|.. .|||. |.   ...|.. |.|  .   |  |  .||..||     
lrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggi.spklesledikkikrplkevtedslaqdllfadpldvql

---PGRSP-----SKRGVGIQFGPDVTKKFLEHNNLEYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFINLGAD
   . . |      .||. . |     ... .. ||. |||.| .   |.    | | .|.||||.| ... |||| ... ..
laavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtn
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 214-471 9.8e-44 142.7 In-house 13-290 (302) alignment 
Range on Protein: 214-471
Range on HMM: 13-290/302.0
YTMLVQILAMFKKLPSLCDITIPegkkFTICGDIHGQFYDLLNIFEINGLPSE----------DNPYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHL
.... .. ...||  .| .|. |     || ||||||| ||. |.  .    |           . ..| ||.||||| |.| |  .| .|.||| .. |
lllieaviellkkektlaeispP....vtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyil

SRGNHESDTMNQMYGFYGEVRSKYTN----QMADLFQEVYNWLPLAQLINKKVMVMHGGLfSQDNVTIDDLRIIDRNRQP-PESGLMCELLWSDPQPR--
 |||||. ..|  ||| .|. .....    .. . |.||. ..||| |. .|.. .|||. |.   ...|.. |.|  .   |  |  .||..||     
lrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggi.spklesledikkikrplkevtedslaqdllfadpldvql

---PGRSP-----SKRGVGIQFGPDVTKKFLEHNNLEYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFINLGAD
   . . |      .||. . |     ... .. ||. |||.| .   |.    | | .|.||||.| ... |||| ... ..
laavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtn
PPP_3 215-480 1.7e-101 331.8 In-house 5-270 (271) alignment 
Range on Protein: 215-480
Range on HMM: 5-270/271.0
TMLVQILAMFKKLPSLCDITIPEGKKFTICGDIHGQFYDLlNIFEINGLPSEDNPYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMN
. |.... . |....  ....   .. |.|||||||..|| .... ||.||... |||.||.||||..|.||.|.|. .|..||...|| ||||||...|
nelkelvkklkeilekesnlveisapvtvcGDiHGqldDL.lelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrqin

QMYGFYGEVR-SKYTNQMADLFQEVYNWLPLAQLINKKVMVMHGGLFSQDNvTIDDLRIIDRNRQPPESGLMCEL-LWSDPQPRPGRSPSKRGVGIQFGP
..|||. ||  .|..... . .|||...||||.||..||.|.||||... . ..|... ..|... ||.|....| |.|||. . | ..||||.|. |||
kvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsik.sldqikklerkievpeegklldlllssdpekeeglenskrGagllFgp

DVTKKFLEHNNLEYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFINLGADLKPNFKTYE
|||..|||.|.|..|.|.||.|..|||..||||..|||||||||....|.||...|...|...||..|
dvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
PPP_1 215-467 2.7e-95 311.6 In-house 4-263 (264) alignment 
Range on Protein: 215-467
Range on HMM: 4-263/264.0
TMLVQILAMFKKLPSLCDITIPEGKKFTICGDIHGQFYDLlNIFEINGLPSEDNPYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMN
. |.... . |.|..  ....   .. |.||||||||.|| ...  .|.||... |||.||.||||..|||..|.|. .|| ||....| ||||||....
eelaelkkklkellnkeenllevseeitvcGDiHGqfdDL.lklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvt

QMYGFYGEVR-SKYTNQMADLFQEVYNWLPLAQLINKKVMVMHGGLFSQDNvTIDDLRIIDRNRQPPESGLMCELL--------WSDPQPRPGRSPSKRG
..|||. ||.  ||.... .....|...||||.||..|....|||| .. . ..|. |...|... ||.| .|.||        ..|.. . . . |.||
kvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeld.lldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

VGIQFGPDVTKKFLEHNNLEYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFIN
.| .||.|||.|||..|||..|.|.||||..|||.....|..|.|||.||... .|.||...
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
subfamily_PPP1C_pd Subfamily PPP1C 216-478 3.2e-84 275.4 In-house 18-275 (282) alignment 
Range on Protein: 216-478
Range on HMM: 18-275/282.0
MLVQILAMFKKLPSLCDITIPegkkFTICGDIHGQFYDLLNIFEINGLPSEDNpYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMNQ
.| .  ..... | | ... |     .|.||||||..|||..||..| |.| | ||| ||.||||..|.|.|. |. .|. ||....| ||||||  .|.
llkkareillsqpilleleaP....vkivgdihGqyadllrlfetsgaPpesn.ylflGdyvdrGkqsletivlllaykikypenlfllrGnhesasinr

MYGFYGEVRSKYTNQMADLFQEVYNWLPLAQLINKKVMVMHGGLfSQDNVTIDDLRIIDRNRQPPESGLMCELLWSDPQPR-PGRSPSKRGVGIQFGPDV
.|||| |.. .|....   |..|.|.|||| |...|....|||| |..   ....| | |  . ||.||.|.||||||. .  | | ..||| ..||.||
iyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGl.spelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsftfgkdv

TKKFLEHNNLEYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFINLGADLKPNFKT
 .|||..|.|. |||.|.| .||||   . . .|||||||||....|.|| ... ..|. .|. 
vekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqi
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 216-477 3.4e-64 209.9 In-house 31-290 (297) alignment 
Range on Protein: 216-477
Range on HMM: 31-290/297.0
MLVQILAMFKKLPSLCDITIPegkkFTICGDIHGQFYDLLNIFEINGLPSEDNpYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMNQ
.|   | .||.  |. ..  |      .|||||||| ||| .|   | |   | ||| ||.|||| ||.| |. |. .|. .|  . | ||||| . .|.
lldlaldvfkaqksmvevnap....ikvcgdihgqfpdllrlfhrggwpptan.ylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecefvnk

MYGFYGEVRSKYTN-QMADLFQEVYNWLPLAQLINKKVMVMHGGLFS--QDNVTIDDLRIIDRNRQPPEsGLMCELLWSDPQP-RPGRSPSKRGVGIQFG
.|||| |.. .|   .|   ||.|.|||||. || .|...|||||     ...|.| || |.|...  | .|...|||.||     |    .|| |  ||
vygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierstegke.rlvadllwadpisglsgfmenqrgagcgfg

PDVTKKFLEHNNLEYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFINLGADLKPNFK
 |   |   . .|. ..|.|.| .||||.    | .|.|||| || |. |  ||.     |.  |.
rdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfe
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 217-478 9.9e-66 214.8 In-house 17-273 (281) alignment 
Range on Protein: 217-478
Range on HMM: 17-273/281.0
LVQILAMFKKLPSLCDITIPegkkFTICGDIHGQFYDLLNIFEINGLPSEDNpYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMNQM
. .. |.| .  .|..|  |     .. ||.|.|| || ..||. | ..|.  ..| ||.||||  |.||.. || .|. |.|.  | |||||  ..|..
ireveaifseekaLveidkP....ivvvGdlhaqfndlkrlfellgrvpeev.lvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvnki

YGFYGEVRSKYTNQMADLFQEVYNWLPLAQLINKKVMVMHGGLfSQDNVTIDDLRIIDRNRQPPESGLMCELLWSDPQPRP-GRSPSKRGVGIQFGPDVT
|||| |   ||  ..  |||. .| ||...||.|.|..||||| | . ...|.|| . .  .... ||. .|||.||...  .   | ||..  || .| 
ygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGl.sPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfGknvv

KKFLEHNNLEYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFINLGADLKPNFKT
..   . ..|.|.|.| |  |||||    | |||||.||||..  | .| . . ..|. ....
ddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislva
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 220-485 2e-57 187.8 In-house 18-278 (280) alignment 
Range on Protein: 220-485
Range on HMM: 18-278/280.0
ILAMFKKLPSLCDITIPegkkFTICGDIHGQFYDLLNIFEINGLPSEDNpYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMNQMYGF
. |.| .   ||.   |      . |||| |. |.  .|.. |   |..  .| ||.||||   .||.. || .|. | |. .| |||||. ..|..|||
veaifmeesnlceaeap....ikvigdihaqyqdmnrlfdligrvpeek.lmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiygf

YGEVRSKYTNQMADLFQEVYNWLPLAQLINKKVMVMHGGLfSQDNVTIDDLRIIDRNRQPPESGLMCELLWSDPQPR-PGRSPSKRGVGIQFGPDVTKKF
| |.. ||   .   || ..| .|.. ||.|.|..||||| | . . .| .| | |  .| . ||. .||||||  .  |   | ||.   ||  | .. 
yvecqykygvglwwdfqscfnrmpmsgliskrvlcmhggl.spelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkgvveqa

LEHNNLEYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFINLGADLKPNFKTYEAVPHP
 .  ... |.|.|.| .||||.    . ||||| |||| |. |  | . | |.|. .|.     | |
cksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlippplp
subfamily_PPZ_pd Subfamily PPZ 223-477 6.9e-56 182.9 In-house 40-289 (300) alignment 
Range on Protein: 223-477
Range on HMM: 40-289/300.0
MFKKLPSLCDITIPegkkFTICGDIHGQFYDLLNIFEINGLPSEDNpYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMNQMYGFYGE
.|   |.| ... .      | ||.|||. ||| .|   |.|   | ||| ||.||||  |.| || |. .|. ||. | | |||||   . ..|||| |
lflaqpallelsps....vkivgdvhgqyadllrlftkcgfppsan.ylflgdyvdrgkqsletillllcykikypenffllrgnhecanvtrvygfyde

VRSKYTNQMADLFQEVYNWLPLAQLINKKVMVMHGGLFSQDNvTIDDLRIIDRNRQPPESGLMCELLWSDPQPRPGR-SPSKRGVGIQFGPDVTKKFLEH
.. .   ..   | . .| |||| ..  |....||||    | ..|..| . |  . |. ||. .||||||   .      .|||   .     .|||..
ckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvln.smdeirhvvrptdvpdfglindllwsdptdssnewednergvsycynkvainkflnk

NNLEYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFINLGADLKPNFK
  .. ..|.| | .||||.  |   .||||||||| .. | || ...   |  .|.
fgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfe
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 229-468 2.5e-50 164.4 In-house 41-278 (307) alignment 
Range on Protein: 229-468
Range on HMM: 41-278/307.0
SLCDITIPegkkFTICGDIHGQFYDLLNIFEINGLPSEDnPYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMNQMYGFYGEVR---S
.| ||  |      . ||.|||| ||.|.| . | | |   |.| ||.|||| .|.|.|| || .|. ||..  | |||||   .|. |||| |.     
alvdidpp....cvvvgdlhgqfndlinmfillgrppet.vyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygfyeecvtsip

KYTNQMADLFQEVYNWLPLAQLINKKVMVMHGGLfSQDNVTIDDLRIIDRNRQPPESGLMCELLWSDPQPRPG-RSPSKRGVGIQFGPDVTKKFLEHNNL
|  ...  ||| ..| ||.. ||  |...||||| |     .|.||   .  . |  |.. ..||.||.|       | || |. || .|         .
kcgeeiwalfqrcfnnlpisaliatkilcmhggl.spaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgtnviddvckrlgv

EYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFINL
| |.|.|..  ||| |    | ||.|||| ||.   | |. ...
eliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkv
subfamily_YNL217W_pd Subfamily YNL217W 237-365 1e-06 21.4 In-house 8-142 (235) alignment 
Range on Protein: 237-365
Range on HMM: 8-142/235.0
EGKKFTICGDIHGQFYDLLNIFEINGLP-SEDNPYLFNGDFVDRGSFSVEVILTLfgfkllYPDHFHLSRGNHESDTMN------QMYGFYGEVRSKYTN
 ||.. . ||.|| . .|..... .     |.   .. ||....|  ||||.  .        |. .  .||||  ..       .  |.     |. ..
lgkrllvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllaykwvkkpkgaeplefsskfs

QM-ADLFQEVYNW---LPLA-QLINKKVMVMHGGLFSQDNV
 .  .| .. ...   |. . ..  ....|.|.|| ... .
flesklskadmeyarelgfsldipsdellvvhaGlvpgkfl
subfamily_PPP6C_pd Subfamily PPP6C 239-484 2e-73 240.1 In-house 42-286 (290) alignment 
Range on Protein: 239-484
Range on HMM: 42-286/290.0
KKFTICGDIHGQFYDLLNIFEINGLPSeDNPYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMNQMYGFYGEVRSKYTNQMAD-LFQE
   |.|||||||||||...|   |    |. |.| ||||||| .|.| .  |. .|. |||.  | ||||||  . |.|||| |  .|| |  |   . .
spvtvcgdihgqfydleelfrtggqvp.dtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesrqitqvygfydeclnkygnanawkyctk

VYNWLPLAQLINKKVMVMHGGLfSQDNVTIDDLRIIDRNRQPPESGLMCELLWSDPQPRPGRSPSKRGVGIQFGPDVTKKFLEHNNLEYIVRSHEVKNDG
|.. |..| .|...|. .|||| | |  |.|..|.|.|... |. | .|.|.||||.     . |.|| |  ||  |||.|.. |||. |.|.|.. ..|
vfdlltiaaiideqvlcvhGgl.spdvktldqirvieraqeiphkgafcdlvwsdpedvetwavsprgagylfgskvtkefvhinnlklicrahqlveeg

YEVTHDGKCITVFSAPNYCDQIGNKGAFINLGADLKPNFKTYEAVPH
..   | | .||.|||||| . ||  . ..|  . . ..| ..|||.
lkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfkavpd
Metallophos Calcineurin-like phosphoesterase 240-434 3.1e-42 138.1 Pfam-A 2-199 (200) alignment 
Range on Protein: 240-434
Range on HMM: 2-199/200.0
KFTICGDIHGQFYDL---LNIFEINGLPSEDNPYLFNGDFVDRGSFSVEVILTL--FGFKLLYPDHFHLSRGNHESDTMNQMYGFYGEVR----------
.....||.||...||   |.|.. .. ... ...||.||.||||  | |..  |  .  |||.|....| ||||||| .|. |||. |.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------SKYTNQMADLFQEVYNWLPLAQLINKKVMVMHGGLFSQDNVTIDDlriidrnrqppesglmcellwsdpqprpgrs
                         ....  .. ..|....|||. |...|. ..||.|.| .. . |                                
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

pskrgVGIQFGPDVTKKFLEHNNLEYIVRSHEVK
      .  ||||.. |.|| ... ...|.|. |
.....gselfgpdalekllekygvdlvlrGHtHk
subfamily_PPP4C_pd Subfamily PPP4C 241-483 1.4e-79 260.3 In-house 45-286 (288) alignment 
Range on Protein: 241-483
Range on HMM: 45-286/288.0
FTICGDIHGQFYDLLNIFEINGLPsEDNPYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMNQMYGFYGEVRSKYTNQ-MADLFQEVY
 |.||||||||||||..|...|   ... ||| ||||||| .||| .| |  .|. |||. .| ||||||  . |.|||| |. .|| .. .  .  ||.
vtvcgdihgqfydllelfkvggdv.petnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrqitqvygfydeclrkygsanvwryctevf

NWLPLAQLINKKVMVMHGGLfSQDNVTIDDLRIIDRNRQPPESGLMCELLWSDPQPRPGRSPSKRGVGIQFGPDVTKKFLEHNNLEYIVRSHEVKNDGYE
..|.|| .|..|....|||| | .  |.|..|.|||... |..| .|.||||||.   | . | || |  || ||...| |.|..| |.|.|..  .|| 
dylslaaiidgkifcvhggl.spsistldeirsidrkqevphegplcdllwsdpedaegwavsprgagylfgsdvveqfneandielicrahqlvmegyk

VTHDGKCITVFSAPNYCDQIGNKGAFINLGADLKPNFKTYEAVP
.  . | .||.|||||| . ||. | ..| ..|. .|| .||..
lhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaaa
subfamily_PPP2C_pd Subfamily PPP2C 241-484 2.6e-78 256.1 In-house 46-288 (290) alignment 
Range on Protein: 241-484
Range on HMM: 46-288/290.0
FTICGDIHGQFYDLLNIFEINGlPSEDNPYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMNQMYGFYGEVRSKYTNQ-MADLFQEVY
 |.|||.||||.|||..| | |  | |  ||| ||.|||| .||| .  |  .|. |..   . ||||||  . |.||||.|.  ||.|  .  .| ...
vtvcgdvhgqfhdllelfkigg.kspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhesrqitqvygfydeclrkygnanvwkyftdlf

NWLPLAQLINKKVMVMHGGLfSQDNVTIDDLRIIDRNRQPPESGLMCELLWSDPQPRPGRSPSKRGVGIQFGPDVTKKFLEHNNLEYIVRSHEVKNDGYE
..|||. |........|||| |    |.|..| .|| .. |. | .|.||||||. | | . |.|| | .|| |...|| ..|.|..|.|.|..  .||.
dylpltalvdeqifclhggl.spsidtldkiraldrlqevphegplcdllwsdpddrggwgisprgagytfgkdisekfnktngltliarahqlvmegyn

VTHDGKCITVFSAPNYCDQIGNKGAFINLGADLKPNFKTYEAVPH
..|| . .|.||||||| . ||..| ..|  .|| .| .... |.
wshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpapr
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 241-478 7.7e-74 241.7 In-house 37-279 (284) alignment 
Range on Protein: 241-478
Range on HMM: 37-279/284.0
FTICGDIHGQFYDLLNIFEINGLP-----SEDNPYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMNQMYGFYGEVRSKYTNQMADLF
 .|.||||||| ||| ....|| |     .... ||| ||.|||| ||.|||. || .|||.||.  | ||||||  .|. |||| | . .|.... . |
vkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrgnhesrpvnmqygfyleckkrysealyeaf

QEVYNWLPLAQLINKKVMVMHGGLfSQDNVTIDDLRIIDRNRQPPESGLMCELLWSDPQPR-PGRSPSKRGVGIQFGPDVTKKFLEHNNLEYIVRSHEVK
|  .| .||. ...||.. ||||. |.| . ...|  ..|  . |. |....| |.||. .  |   |.|| |  ||..  |.||.. .|. .||.|.| 
qlafnamplcavvskkiicmhggi.sedlldlkqldklerpidipdigviadltwadpeaevegykesprgagkvfgakavkeflkkfkldlvvrahqvv

NDGYEVTHDGKCITVFSAPNYCDQIGNKGAFINLGADLKPNFKT
 ||||   | | .|.|||| || |. | .| .|.  .|   |..
mdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftv
subfamily_PPG1_pd Subfamily PPG1 241-484 9.1e-72 234.8 In-house 43-298 (300) alignment 
Range on Protein: 241-484
Range on HMM: 43-298/300.0
FTICGDIHGQFYDLLNIFEINGlPSEDNPYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMNQMYGFYGEVRSKY--TNQMADLFQEV
 |. ||.||||||.|.||.| | .  |  ||| ||.|||| .||| |  |  .|| ||   .| ||||||  . |.||||.|.  ||   ... . . |.
vtvvgdvhgqfydvleifkigg.qvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrqitqvygfyteclrkyggnsrvwkyltei

YNWLPLAQLINKKVMVMHGGLfSQDNVTIDDLRIIDRNRQPPESGLMCELLWSDPQ-------PRPGRSP-----SKRGVGIQFGPDVTKKFLEHNNLEY
...| || .|.......|||| | .  .||.....|| |. |. | ...||||||.        .| |.      |.|| |  .| ||..|||. |... 
fdylvlaaiideeiycvhggl.spsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqhfvvsqrgagysygkdvvekflrnndmnr

IVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFINLGADLKPNFKTYEAVPH
|.|.|.. |.||..  |.|  ||.|||||| . ||| . ..|   ..  |..||. |.
iirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeeape
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 241-477 1.5e-69 227.3 In-house 35-270 (280) alignment 
Range on Protein: 241-477
Range on HMM: 35-270/280.0
FTICGDIHGQFYDLLNIFEINGLPSEDNpYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMNQMYGFYGEVRSKYTNQMADLFQEVYN
 ..|||.|||. ||| .|.  ..| ..| ||| ||.||||.. .|||| |. .|. ||..| . |||||  ..|. |||. ||. .|.... . |||...
vavcgdlhgqytdllrlfarvsfppdqn.ylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisinrkygfkdevkrryslalynefqelld

WLPLAQLINKKVMVMHGGLfSQDNVTIDDLRIIDRNRQPPESGLMCELLWSDPQ-PRPGRSPSKRGVGIQFGPDVTKKFLEHNNLEYIVRSHEVKNDGYE
 |||. |.. ....||||| ||. |..|||. . |  ..... |  .|||.||.    | . . ||| ..|| .| |.. |. ... |.| |.| .||||
slplvalvsgrilcmhggl.sqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifganvvkdltekldidliarghqvvqdgye

VTHDGKCITVFSAPNYCDQIGNKGAFINLGADLKPNFK
   | | .||||||.|.... |. | . . . |.  |.
ffadkklvtvfsapkylgefdnsaavlivderlivsfe
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 241-467 3.5e-45 147.7 In-house 9-241 (263) alignment 
Range on Protein: 241-467
Range on HMM: 9-241/263.0
FTICGDIHGQFYDLLNIFEINGLPSeDNPYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMNQMYGFYGEVRSKYTN-----QMADLF
  |||| |||. ||| ||.  |  .    ||| ||.|||| .|.|||. || .||  | ..|| |||||  ..|. |||. |.. ..        . . |
inicgdthgqyndllrifnacgaat.ktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesvynhf

QEVYNWLPLAQLINKKVMVMHGGLfSQDNVTIDDLRIIDRNRQPP-ESGLMCELLWSDPQP-RPGRSPSK-RGVGIQFGPDVTKKFLEHNNLEYIVRSHE
..|....||. ...|....||||. |    ..||.| |    .      | |.|||.||.    |  | | | .   ||      . .. ... |||.|.
nqvfsymplcaivskrilcmhggi.sphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidlivrahq

VKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFIN
| . || .  | . ||||||  |  .. |  | . 
vveygyaffadrrlitvfsasryqielcnyaavvv
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 241-267 9.5e-08 24.5 In-house 38-65 (317) alignment 
Range on Protein: 241-267
Range on HMM: 38-65/317.0
FTICGDIHGQFYDLLNIFEINGLP-SED
 ||.||||||| ||| ....|| | |..
vtivGdihGqfedllalldlnGwplssq
PPP_4 242-434 1.8e-75 246.3 In-house 2-197 (197) alignment 
Range on Protein: 242-434
Range on HMM: 2-197/197.0
TICGDIHGQFYDL-LNIFEINGLPSEDNPYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMNQMYGFYGEVRSKYTNQMADLFQEVYN
|..||||||..|| |..... |||||.. |.|.||.||||..|.||.|.|. .|| ||....| ||||||  .|..|||. || .|..... . .|.|..
tvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvfd

WLPLAQLINKKVMVMHGGLFSQDNvTIDDLRIIDRNRQPP-ESGLMCEL-LWSDPQ-PRPGRSPSKRGVGIQFGPDVTKKFLEHNNLEYIVRSHEVK
.||||.||..||.|.||||... . ..|... |.|... | |......| |||||.    | ..|.||.|. ||||||.||||.|||..|.||||.|
llplaalidekvlvvhgglsdele.sldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshelk
PPP_2 242-434 6.1e-74 241.0 In-house 2-198 (198) alignment 
Range on Protein: 242-434
Range on HMM: 2-198/198.0
TICGDIHGQFYDLlNIFEINGLPSEDNPYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMNQMYGFYGEVR-SKYTNQMADLFQEVYN
|.|||.|||..|| .|.  |||||... |||.||.||||..|.||.|.|. .|| ||...|| ||||||...|..|||. ||  .|..... . .|||..
tvcGDlHGqldDL.lilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

WLPLAQLINKKVMVMHGGLFSQDNvTIDDLRIIDRNRQPPESGLMCEL-----LWSDPQPRPGRSPSKRGVGIQFGPDVTKKFLEHNNLEYIVRSHEVK
.||||.||..||.|.||||... . ..|. . ..|... ||.|....|     |..... . . ..|.||.|. ||||||...||.|.|..|.|.||||
lLplaalidekvlvvHGGlseeik.lldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHevk
PPP_5_Dcr2 242-434 5.9e-73 238.1 In-house 2-199 (199) alignment 
Range on Protein: 242-434
Range on HMM: 2-199/199.0
TICGDIHGQFYDLLNIFEING-LPSEDNPYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMNQMYGFYGEVRSK-YTNQMADLFQEVY
|.|||.|||..||| |.. .| .|||.. |.|.||.||||..|.||.|.|. .||.||...|| |||||.  .|..|||. || || . ... . ...|.
tvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdvf

NWLPLAQLINKKVMVMHGGLFSQDNvTIDDLRIIDRNRQPP-ESGLMCEL-LWSDPQ-PRPG-RSPSKRGVGIQFGPDVTKKFLEHNNLEYIVRSHEVK
.|||||.||..||.|.||||... . .|..|. |.|... | |.| ...| |||||.    |   .|.||.|. ||||||.||||.|||..|.||||.|
dwlPlaalidekvlvvhgglspeik.siellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk
subfamily_PPPLV_pd Subfamily PPPLV 243-466 2.5e-41 134.9 In-house 28-273 (290) alignment 
Range on Protein: 243-466
Range on HMM: 28-273/290.0
ICGDIHGQFYDLLNI---FEINGLPSEDNPYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMNQMYGFYGEVRSKYTNQMADL---FQ
. ||.||.. ||  .   .   |       .|| ||.|||| ||||.|  |.  |.||| ...| ||||| ... . . ..||   |. ... .    |.
vlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqesieykgegsfkfgdsleevweafn

EVYNWLPLAQLINKKVMVMHGGLFSQ--DNVTID-DLRIIDRNRQPPE-SGLMCELLWSDPQPRP------------G-RSPSKRGVGIQFGPDVTKKFL
.|...||||  |..||. .|.|.      .  |     |..| ... . . |  ..|||||.               |  . ..|| |  |. |  ..||
nvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvlneGfvdndrrGtghvfsedaleafl

EHNNLEYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQiGNKGAFI
..|||....|.||||. |... ..|. .||||. .|| .  |. | |
krnnlsfvlrahevkekGirlqqkgrlltvfsssrycGs.sneaali
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 269-479 2.1e-67 220.6 In-house 102-312 (317) alignment 
Range on Protein: 269-479
Range on HMM: 102-312/317.0
PYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMNQMYGFYGEVRSKYTNQMADLFQEVYNWLPLAQLINKKVMVMHGGLfSQDNVTID
 ||| ||.|||| ||.||.. || .||||||. .| |||||| ..|. |||| ||. .| ... . || ..| |||. ..|||.. ||||. |.. . ..
kylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGi.seelldlk

DLRIIDRNRQPPESGLMCELLWSDPQPR-PGRSPSKRGVGIQFGPDVTKKFLEHNNLEYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFIN
 |  ..|  . |. |....| |.||...  |  .|.|| |  ||..  |.||.. .|. .||.|.| .||||   | | .|.||||.|| |. | .| ..
qldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavls

LGADLKPNFKTY
.  .||  ....
vdkklkisinvl
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 269-474 5.9e-55 179.7 In-house 121-326 (339) alignment 
Range on Protein: 269-474
Range on HMM: 121-326/339.0
PYLFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLSRGNHESDTMNQMYGFYGEVRSKYTNQMADLFQEVYNWLPLAQLINKKVMVMHGGLfSQDNVTID
 ||| ||.|||| ||.||.. |  .|| |||. .| |||||| ..|  |||| ||  .|  |. . ||...| .|.. .||. .|.||||. |.   ...
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggi.sehltsfn

DLRIIDRNRQPPESGLMCELLWSDPQPR-PGRSPSKRGVGIQFGPDVTKKFLEHNNLEYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFIN
.. .. |  . |. |.. .| |.||.|   |  || ||  . |||   . ||.. .|. ..| |.| .||||.    . .|.||||||| |  |  | . 
qfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfs

LGADLKP
.   || 
idkklki
subfamily_PPP7C_pd Subfamily PPP7C 385-482 1.1e-33 109.5 In-house 237-335 (383) alignment 
Range on Protein: 385-482
Range on HMM: 237-335/383.0
MCELLWSDPQPRPGRSPS-KRGVGIQFGPDVTKKFLEHNNLEYIVRSHEVKNDGYEVTHDGKCITVFSAPNYCDQIGNKGAFINLGADLKPNFKTYEAV
. ..|||||. . |  |   || |. ||||||||.|.. ||....|||| | .|||..|| |..|.||| || ..  |.||...|| ||.|..  | | 
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqyqas