Gene PPP6C-2 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP6C
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP162_AA protein Get Run
SpurP162_AA_3-293 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0045823 Metallo-dependent phosphatases 4-293 6e-106 347.8 In-house 27-328 (473) alignment 
Range on Protein: 4-293
Range on HMM: 27-328/473.0
XSNLDRWIEIAKXCKYLPENDLKKLCDLVXDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIXMGDXVDRGYYSXETFTRLLTLKAK
 ..||..||. | ...|||.||.||.| . ..  .| |....| ...|.||||||..||..|..  | .|.. .. .|| ||||..| |.. .|| || |
lldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkik

FPDRIVLXRGNHESXQITQVYGFYDECQTKYgNANAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIXQIXMIERAQEIPHKGAFCDLVWSDPDNV
.|....| |||||. .....|||.||.  || ... .... .... | .||.|....|.||||||||.... || .||| .|||. |...||.||||...
ypgnvfllrGNHElrllnglygfgdetleky.gedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdPwed

ET--------WAISPRGAGWLFGXKVTNXFVHXNNLKLICXAHQLVQEGYKYMFDDK------LVTVWSAPNYCYRCGNIASILAFNDATtREAKLFRNV
.         .  ||||||.||| .... | . |.|.||. .|. |.|||...||.|      ..||.||||||.|.|| |..| ... . .. ..|. .
dgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdps

PDSE
|.  
phpl
subfamily_PPP2C_pd Subfamily PPP2C 5-288 4e-129 422.9 In-house 2-285 (290) alignment 
Range on Protein: 5-288
Range on HMM: 2-285/290.0
SNLDRWIEIAKXCKYLPENDLKKLCDLVXDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIXMGDXVDRGYYSXETFTRLLTLKAKF
..||..||  | || | |...|.||. . ..  .| |||.|..|||||||.||||.|| |||. ||. ||| |. .|| ||||||| || | | .|| ..
kdldklieklkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvry

PDRIVLXRGNHESXQITQVYGFYDECQTKYGNANAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIXQIXMIERAQEIPHKGAFCDLVWSDPDNVE
..||.. |||||| ||||||||||||  |||||| |.| |..|| |...|..|||..|.|||||| ..|. .|  ..| ||.||.|..|||.|||||. .
keritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddrg

TWAISPRGAGWLFGXKVTNXFVHXNNLKLICXAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFNDATTREAKLFRN
 |.|||||||. || .... | . |.|.||  ||||| |||....| ..||..||||||||||| |.|| ..|. ...   |  
gwgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdp
0049330 Metallo-dependent phosphatases 5-293 1.6e-101 332.4 In-house 15-303 (309) alignment 
Range on Protein: 5-293
Range on HMM: 15-303/309.0
SNLDRWIEIAKXCKYLPENDLKKLCDLVXDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIXMGDXVDRGYYSXETFTRLLTLKAKF
|.||..||. . .|.|.|..|..|.. . .. ..| |....| ...|.||||||..||..|..  | .|.. .. .|| ||||..| |....|| || ..
slldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalklly

PDRIVLXRGNHESXQITQVYGFYDECQTKYGnANAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIXQIXMIERAQEIPHKGAFCDLVWSDPD-NV
||...| |||||. .....|||.||.. ||| |. |........ | .||.|....||||||||||.... || ..|| .|||. | .|||.||||.  .
pdnvfllrGNHElrllnglygfgdetlrkyg.aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpir

ETWAISPRGAGWLFGXKVTNXFVHXNNLKLICXAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFNDATTREAKLFRNVPDSE
|..| .|||.|..||  ... |.. |.|.||. .|..|..||...||.||.||.||||||.|.|| ...| ... .... .||. ||   
egfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvplll
0053225 Metallo-dependent phosphatases 5-290 3e-98 321.7 In-house 7-292 (293) alignment 
Range on Protein: 5-290
Range on HMM: 7-292/293.0
SNLDRWIEIAKXCKYLPENDLKKLCDLVXDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIXMGDXVDRGYYSXETFTRLLTLKAKF
..||..||. . .|.|.|..|..|.... .. ..| |....| ...|.|||||...||..|..  | .|.. .. .|| ||||..| |....|| ||...
llldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalklly

PDRIVLXRGNHESXQITQVYGFYDECQTKYGNANAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIXQIXMIERAQEIPHKGAFCDLVWSDPDNVE
||..|| |||||. .....|||.||.  |||.|. |........ | .||.|....|.||||||||. .. || .|.| ..||. |...||.||||| ..
pdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpdlws

TWAISPRGAGWLFGXKVTNXFVHXNNLKLICXAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFNDATTREAKLFRNVP
.|..|.||.|..||  ..  |.. |.|.||. .||.|..||...||.|||||.|||||..|.|| ...||... .... |||. |.
gwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapvl
subfamily_PPP6C_pd Subfamily PPP6C 6-294 5.2e-181 593.1 In-house 1-289 (290) alignment 
Range on Protein: 6-294
Range on HMM: 1-289/290.0
NLDRWIEIAKXCKYLPENDLKKLCDLVXDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIXMGDXVDRGYYSXETFTRLLTLKAKFP
.||.|||.|| |||||||||||||||| ||.|||.||||||.||||||||||||||||||||||||.|||||. .|| ||||||| ||||||||||||.|
eldkwielakkckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakyp

DRIVLXRGNHESXQITQVYGFYDECQTKYGNANAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIXQIXMIERAQEIPHKGAFCDLVWSDPDNVET
|||.| |||||| ||||||||||||..||||||||.||||||||||||||||||||||||||||||||. || .|||||||||||||||||||||..|||
dritllrgnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpedvet

WAISPRGAGWLFGXKVTNXFVHXNNLKLICXAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFNDATTREAKLFRNVPDSER
||.||||||.||| |||. ||| ||||||| |||||.||.|||||.|||||||||||||||||.|||||..||..||||||..|||.||
wavsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfkavpdeer
subfamily_PPP4C_pd Subfamily PPP4C 6-290 7.3e-139 454.9 In-house 2-286 (288) alignment 
Range on Protein: 6-290
Range on HMM: 2-286/288.0
NLDRWIEIAKXCKYLPENDLKKLCDLVXDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIXMGDXVDRGYYSXETFTRLLTLKAKFP
.||| ||  . |. . |...|.||  . .. .||.||| | .||||||||||||||| |||. ||..|.|.|. .|| ||||.|| |||  ||.||...|
dldrqieklrrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvryp

DRIVLXRGNHESXQITQVYGFYDECQTKYGNANAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIXQIXMIERAQEIPHKGAFCDLVWSDPDNVET
|||.| |||||| ||||||||||||  |||.|| |||||.|||.|..|||||....||||||||...|. .| .|.| ||.||.|..|||.||||...|.
dritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedaeg

WAISPRGAGWLFGXKVTNXFVHXNNLKLICXAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFNDATTREAKLFRNVP
||.||||||.||| .|.. |.. |...||| |||||.||||..|..|..||||||||||||||.|.|| ..... .. |.| ...
wavsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaaa
subfamily_PPG1_pd Subfamily PPG1 7-292 8.4e-114 372.9 In-house 1-299 (300) alignment 
Range on Protein: 7-292
Range on HMM: 1-299/300.0
LDRWIEIAKXCKYLPENDLKKLCDLVXDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIXMGDXVDRGYYSXETFTRLLTLKAKFPD
||. .|  . .. |||  .|.|.| . .| ..| ||. . .|||| ||.||||||. |.|. |||.||| |. .|| ||||.|| || . |..|| ..| 
ldecleklqkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklryps

RIVLXRGNHESXQITQVYGFYDECQTKY-GNANAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIXQIXMIERAQEIPHKGAFCDLVWSDPD----
|| | |||||| ||||||||| ||  || ||.. |.| |..|| |..||||||.. ||||||||.|..| || ...| .|.|..||..||.||||.    
ritllrgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennn

------NVE--TWAISPRGAGWLFGXKVTNXFVHXNNLKLICXAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFNDATTREAKLFRNVPDS
      . |   . .|.||||. .| .|.. |.. |... |  ||||..|||. .||.|| |||||||||||||| ||||  ..   |  . . . |.|
ptldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeeapes
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 14-279 5e-79 258.4 In-house 18-284 (298) alignment 
Range on Protein: 14-279
Range on HMM: 18-284/298.0
AKXCKYLPENDLKKLCDLVXDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIXMGDXVDRGYYSXETFTRLLTLKAKFPDRIVLXRG
.| .| . |.|..||..|. ..  .   .  | .|..||||||||. ||  ||  .|  ||. |. .|| |||| .. |. . ||. |.|.|....| ||
kkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnffllrG

NHESXQITQVYGFYDECQTKYGNANAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIXQIXMIERAQEIPHKGAFCDLVWSDPDN-VETWAISPRG
|||  .| .|||||.||. .| . . .    .||. | ..|.| ...||.|||||. .|.. |.  ..|... ...    ||.|.||.| |. || . ||
nheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenavkgwaensrG

AGWLFGXKVTNXFVHXNNLKLICXAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFNDAT
..  || .| . ...  .. |.. |||.||.||... . ||||..|||.|| .  | |...  ..  
vsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdekl
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 16-277 2.4e-64 210.5 In-house 19-283 (297) alignment 
Range on Protein: 16-277
Range on HMM: 19-283/297.0
XCKYLPENDLKKLCDLVXDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIXMGDXVDRGYYSXETFTRLLTLKAKFPDRIVLXRGNH
 .| . |. . || ||  |.   . ..  | .|. ||||||||| ||  ||. ||  | . |. .|| |||| .| ||   ||. | |||  ..| ||||
lskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnh

ESXQITQVYGFYDECQTKYGNANAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSP---DVKTIXQIXMIERAQEIpHKGAFCDLVWSDPD-NVETWAISPR
|   . .|||||.||| .|     .     ||. | .. .| ...||.||||||   .  |.  .  |||..|  ...  .||.|.||   .  .    |
ecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisglsgfmenqr

GAGWLFGXKVTNXFVHXNNLKLICXAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFND
|||  ||       .   .| |.| |||.||.||...   ||||..||| || .  | |.... ..
gagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscde
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 18-290 1.2e-70 231.1 In-house 22-295 (299) alignment 
Range on Protein: 18-290
Range on HMM: 22-295/299.0
KYLPENDLKKLCDLVXDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIXMGDXVDRGYYSXETFTRLLTLKAKFPDRIVLXRGNHES
| . |..|..||..  .  .... .  | .|. ||||||||. ||  .|   |  ||. .. .|| ||||    |. | ||  | |.|.|. . ||||| 
ksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhec

XQITQVYGFYDECQTKYGNANAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIXQIXMIERAQEIPHKGAFCDLVWSDPDN-VETWAISPRGAGWL
  | .|||||.||. .|  .  |    . |. . .. .|  ..||.|||||| ..|. |.  . | |. |      ||.|.|||. |  |    ||  ..
painrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgvsyv

FGXKVTNXFVHXNNLKLICXAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFNDATTREAKLFRNVP
|| .| .  ..  .. |.. |||.||.||... . ||||..||| || .  | |.|.  ..      ....  |
fgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptp
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 18-277 2.5e-62 203.8 In-house 4-263 (280) alignment 
Range on Protein: 18-277
Range on HMM: 4-263/280.0
KYLPENDLKKLCDLVXDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIXMGDXVDRGYYSXETFTRLLTLKAKFPDRIVLXRGNHES
. .   ..  .  .|  . .||.|.    .|. | |||| |. |.. ||   |..|.   . .|| ||||    | .  |. || .. ||| | |||||.
nvmtgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhet

XQITQVYGFYDECQTKYGNANAWRYCTkVFDLLTIAAIIDEQVLCVHGGLSPDVKTIXQIXMIERAQEIPHKGAFCDLVWSDPDN-VETWAISPRGAGWL
  . ..|||| ||| ||| .  | . . .|. . ....| ..|||.||||||..  .  |  | |  |   .| . ||.|||| |  | |  | ||  ..
psvnkiygfyvecqykygvglwwdfqs.cfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisym

FGXKVTNXFVHXNNLKLICXAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFND
||  | .  ..  .. ||  |||.||.||. |   .|.||.| |||| .  | |.....| 
fgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclna
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 18-68 7.4e-08 24.9 In-house 7-57 (317) alignment 
Range on Protein: 18-68
Range on HMM: 7-57/317.0
KYLPENDLKKLCDLVXDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRT
. . |..| .||    .|  .|     . .|||..||||||| ||  |.  
dlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldl
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 19-281 8.9e-70 228.3 In-house 7-275 (284) alignment 
Range on Protein: 19-281
Range on HMM: 7-275/284.0
YLPENDLKKLCDLVXDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQI------PDTSYIXMGDXVDRGYYSXETFTRLLTLKAKFPDRIVLXR
 | |..| .||    .|  .|   . . .||...||||||| ||  |.   |         .. |. .|| |||| .| |  | |...| ..||...| |
llkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllr

GNHESXQITQVYGFYDECQTKYGNAnAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIXQIXMIERAQEIPHKGAFCDLVWSDPD-NVETWAISPR
|||||  . . |||| ||. .| .|  .      |  . ..|.......|.|||.| |.  . |.  .||  .||  |  .||.|.||. .||... |||
gnhesrpvnmqygfyleckkrysea.lyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykespr

GAGWLFGXKVTNXFVHXNNLKLICXAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFNDATTR
||| .|| |  . |..  .|.|.  |||.|..||... | ||||..||| || .  |||..|  ..    
gagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelva
PPP_3 20-286 3.1e-107 350.6 In-house 2-269 (271) alignment 
Range on Protein: 20-286
Range on HMM: 2-269/271.0
LPENDLKKLCDLVXDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIXMGDXVDRGYYSXETFTRLLTLKAKFPDRIVLXRGNHESXQ
|.||.||.|.. . ..  .| |.. .|.|||||||||||..|| |||..||..|.|.|. .|| ||||..| |... ||.|| |.|....| |||||| |
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

ITQVYGFYDECQTKYGNANAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIXQIXMIERAQEIPHKGAFCDL-VWSDPDNVETWAISPRGAGWLFG
|..||||..|...|.|... ......||.||..||.|||.||.|||||||..|.. ||  .|| .|.|..|...|| ..|||.. |... |.||||.|||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

XKVTNXFVHXNNLKLICXAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFNDATTREAKLF
 .||. |.. |.||||. ||.|..|||....| |.|||.||||||.|..| ..|| ...|.|.| |..
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkql
subfamily_PPP1C_pd Subfamily PPP1C 20-287 1.4e-91 299.6 In-house 10-277 (282) alignment 
Range on Protein: 20-287
Range on HMM: 10-277/282.0
LPENDLKKLCDLVXDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIXMGDXVDRGYYSXETFTRLLTLKAKFPDRIVLXRGNHESXQ
| |.....|..   .. |..  .  .. ||...||||||..||  || |.|  |...|. .|| ||||  | || . ||..| |.|... | |||||| .
lkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesas

ITQVYGFYDECQTKYGNAnAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIXQIXMIERAQEIPHKGAFCDLVWSDPDN-VETWAISPRGAGWLFG
|...|||||||...|..   |.  |.||. | .||..||..|||||||||..| . ||  |.|  |.|.||  |||.|||||. |..|. . ||  . ||
inriyGfydeckrrysik.lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsftfg

XKVTNXFVHXNNLKLICXAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFNDATTREAKLFR
 .| . |.. |.|.||. |||.|..||... . .||||.|||||| . .| ...|. ..  . . ....
kdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilk
subfamily_PPZ_pd Subfamily PPZ 20-277 9.1e-63 205.5 In-house 25-282 (300) alignment 
Range on Protein: 20-277
Range on HMM: 25-282/300.0
LPENDLKKLCDLVXDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIXMGDXVDRGYYSXETFTRLLTLKAKFPDRIVLXRGNHESXQ
| .... ..|    .| | . ..  .| .| . ||.|||. ||  ||   |  | . |. .|| ||||  | ||   ||  | |.|. ..| |||||  .
lknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecan

ITQVYGFYDECQTKyGNANAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIXQIXMIERAQEIPHKGAFCDLVWSDP-DNVETWAISPRGAGWLFG
.|.||||||||. .  | . |.     |. | .|||.  ...|||||||| .... .|  . |  ..|  |   ||.|||| |. . |    ||  . . 
vtrvygfydeckrr.cnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvsycyn

XKVTNXFVHXNNLKLICXAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFND
    | |.    . |.| || .|..||... |  ||||.||||||    |  .... ..
kvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvse
PP2Ac_SM00156 21-288 7.8e-94 306.7 In-house 2-269 (271) alignment 
Range on Protein: 21-288
Range on HMM: 2-269/271.0
PENDLKKLCDLVXDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIXMGDXVDRGYYSXETFTRLLTLKAKFPDRIVLXRGNHESXQI
 ......|.. | ..  .| |.  ||.||||.||||||..|| .|....|. |.. |. .|| ||||..| |. . |..|| ..|...|| |||||| ..
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

TQVYGFYDECQTKYgNANAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIXQIXMIERAQEIPHKGAFCDLVWSDP-DNVETWAISPRGAGWLFGX
...|||..|.. || .....  ....|.||..||..|...||.||||||..... .|  ..|..|.|..| ..||.|||| ........| ||.. .|| 
nkiygfeeevkrky.gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFge

KVTNXFVHXNNLKLICXAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFNDATTREAKLFRN
.... |.. ||||||. ||..|.|||....| ||||..||||||....| |..| ...... .......
davkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlke
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 21-276 6.2e-67 218.7 In-house 7-262 (280) alignment 
Range on Protein: 21-276
Range on HMM: 7-262/280.0
PENDLKKLCDLVXDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIXMGDXVDRGYYSXETFTRLLTLKAKFPDRIVLXRGNHESXQI
 | |.... . . .. . .  .  | .||.||||.|||. ||  ||   .  ||. |. .|| |||| .  |    ||. |...|..... |||||  .|
keadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisi

TQVYGFYDECQTKYGNAnAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIXQIXMIERAQEIPHKGAFCDLVWSDPD-NVETWAISPRGAGWLFGX
 . |||.||.. .| .|  .    ...| | ..|..  ..||.|||||...... ..  . |  . ...    ||.|.||. .|  || ..||.  .|| 
nrkygfkdevkrrysla.lynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifga

KVTNXFVHXNNLKLICXAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFN
.| . ...  .. ||.  ||.||.||... | |||||.|||.|.    | |..|  .
nvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivd
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 21-275 1.3e-45 148.9 In-house 7-286 (302) alignment 
Range on Protein: 21-275
Range on HMM: 7-286/302.0
PENDLKKLCDLVXDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQ-----------IPDTSYIXMGDXVDRGYYSXETFTRLLTLKAKFPDRIV
 ...| .|.. | .|  .| ..  .|.|||. ||||||| ||  .. .  .                .. .|| ||||. | |  . ...||  .| . .
sksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyi

LXRGNHESXQITQVYGFYDECQTKYGNAN---AWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIXQIXMIERA-QEIPHKGAFCDLVWSDPDNVET
| |||||.  |   ||| .| ....|...    |.   .||  . .||.. |..||||||.|| .... .|  |.|  .|. .     ||...|| .|..
llrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvql

WAISP----------RGAGWLFGXKVTNXFVHXNNLKLICXAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAF
 |. .          ||   .|     . . .  |||||  ||| . ||.|.. | ||.|..|||.|     |  ..|  
laavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkv
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 21-275 1.6e-45 148.6 In-house 8-287 (302) alignment 
Range on Protein: 21-275
Range on HMM: 8-287/302.0
PENDLKKLCDLVXDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQ-----------IPDTSYIXMGDXVDRGYYSXETFTRLLTLKAKFPDRIV
 ...| .|.. | .|  .| ..  .|.|||. ||||||| ||  .. .  .                .. .|| ||||. | |  . ...||  .| . .
sksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyi

LXRGNHESXQITQVYGFYDECQTKYGNAN---AWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIXQIXMIERA-QEIPHKGAFCDLVWSDPDNVET
| |||||.  |   ||| .| ....|...    |.   .||  . .||.. |..||||||.|| .... .|  |.|  .|. .     ||...|| .|..
llrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvql

WAISP----------RGAGWLFGXKVTNXFVHXNNLKLICXAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAF
 |. .          ||   .|     . . .  |||||  ||| . ||.|.. | ||.|..|||.|     |  ..|  
laavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkv
PPP_1 22-273 7.5e-101 329.8 In-house 3-262 (264) alignment 
Range on Protein: 22-273
Range on HMM: 3-262/264.0
ENDLKKLCDLVXDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIXMGDXVDRGYYSXETFTRLLTLKAKFPDRIVLXRGNHESXQIT
|. |..|.. . .|  .| |.. ||...||||||||||.|| .||..||. |.|.|. .|| ||||..| |... ||.|| |.|... | |||||| |.|
eeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvt

QVYGFYDECQTKYGNANAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIXQIXMIERAQEIPHKGAFCDL--------VWSDPDNVETWAISPRGA
.||||..|...|..... ....|.|||.|..||.|||..|.|||||||..... ||  ..| .|.|..|..|||        ...|... |..| |.|||
kvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRGa

GWLFGXKVTNXFVHXNNLKLICXAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASIL
|.||| .||. |.. ||||||. ||....|||......|.||..||.||.....| ....
gylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayv
subfamily_PPP3C_pd Subfamily PPP3C 22-278 3.7e-73 239.8 In-house 43-312 (452) alignment 
Range on Protein: 22-278
Range on HMM: 43-312/452.0
ENDLKKLCDLVXDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIXMGDXVDRGYYSXETFTRLLTLKAKFPDRIVLXRGNHESXQIT
|..  |. . . .|  .| ..  |..|.||.|||||||||| .||  ||.  .|.|. .|| |||||.| |.   |..|| ..|... | |||||.  .|
eeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrhlt

QVYGFYDECQTKYGNaNAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIXQIXMIERAQEIPHKGAFCDLVWSDPDN----V---ET-WAISPRGA
. . | .||..||.. . .  |.. || | .||....| |||||||||..|.. .|  ..| .|.|..|..|||.|||| .        |.    |.|| 
eyftfkeeckikyse.evydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpnsvrGc

GWLFGXKVTNXFVHXNNLKLICXAHQLVQEGYKYMFD------DKLVTVWSAPNYCYRCGNIASILAFNDA
 .... | .  |.. |.|  |  ||.  ..||.   .        |.|..|||||.    | |..| ... 
syfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyenn
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 23-292 4.1e-69 225.9 In-house 11-278 (281) alignment 
Range on Protein: 23-292
Range on HMM: 11-278/281.0
NDLKKLCDLVXDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIXMGDXVDRGYYSXETFTRLLTLKAKFPDRIVLXRGNHESXQITQ
......   |  .  || ..  . .|..| ||.|.|| ||..||   |..|.. .. .|| ||||  | |..  |.||| ...||||| |||||  .. .
eeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvnk

VYGFYDECQTKYGNaNAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIXQIXMIERAQEIPHKGAFCDLVWSDPDN-VETWAISPRGAGWLFGXKV
.|||| ||.||||  . |    . |. | |.| |...|||.||||||.. .. ..  . .  . ...|   ||.|.|||| || |  | ||....|| .|
iygfyvecvtkyGe.elwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfGknv

TNXFVHXNNLKLICXAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFNDATtrEAKLFRNVPDS
 .      .. ||  |||.||.||. .   ||.||.|.||||    | |..|  ...   . .| . ||.|
vddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetl..gislvalvpas
subfamily_PPPLV_pd Subfamily PPPLV 26-274 2.9e-46 151.1 In-house 3-275 (290) alignment 
Range on Protein: 26-274
Range on HMM: 3-275/290.0
KKLCDLVXDLQLEECNVQPVSTPVTVCGDIHGQFYDLE----ELFRTGGQIPDTSYIXMGDXVDRGYYSXETFTRLLTLKAKFPDRIVLXRGNHESXQIT
  |||   |  ..| .. .. .|. | ||.||.. ||      |.||| ..  .|.. .|| |||| .| |  . ||.||  .| ...| |||||   ..
lslcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvq

QVYGFYDECQTKYGNA--NAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIXQIXMIERAQE-I--PHKGA--FCDLVWSDPDNVETWA-------
. . .. |.. |.|.   ..|   ..||| | .||.||..|.|||.|.   ..|  .|  |.   | .  . .||    |..||||.. .  .       
esieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvl

------ISPRGAGWLFGXKVTNXFVHXNNLKLICXAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILA
       . || | .|. .  . |.. |||. .  ||.  ..|...  . .|.||.|. .||    . | || 
neGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssneaalilv
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 41-277 1.7e-57 188.1 In-house 24-262 (284) alignment 
Range on Protein: 41-277
Range on HMM: 24-262/284.0
NVQPVSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIXMGDXVDRGYYSXETFTRLLTLKAKFPDRIVLXRGNHESXQITQVYGFYDECQTKYGNANAW
 .  | .|. .|||||||| ||  ||   |    . |. .|| |||| .  ||   |.. |  ||..... |||||   | ..||||.||| .| .   .
mlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinkiygfyeecqrrynkpsvy

RYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIXQIXMIERAQEIPHKGAF-CDLVWSDPDNVE-TWAISPRGAGWLFGXKVTNXFVHXNNLKLICXAH
     ||  . ..|.. ...||.|||.|  .. . |.  |.|  . |   ..  |..|||| |..  |    ||  ..||      ..   .. |.  ||
vsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsdalrklldrlqidlvvrah

QLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFND
|.||.||... . .|||..||| || .  | |...  | 
qvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnk
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 44-278 1.2e-61 201.1 In-house 34-271 (287) alignment 
Range on Protein: 44-278
Range on HMM: 34-271/287.0
PVSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIXMGDXVDRGYYSXETFTRLLTLKAKFPDRIVLXRGNHESXQITQVYGFYDECQTKYGnANAWRYC
 | .|.|..||||||. ||  .|   |. |.. |. .|| ||||  | |    |..|| ..| .. | |||||  .| ..|||..| . |..  . ..  
eveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkkinklyGfkeelkrkrq.erlykqf

TKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIXQIXMIERAQEI--PHKGAFCDLVWSDPDN-VETWAIS-PRGAGWLFGXKVTNXFVHXNNLKLICXAHQ
 .||. |.. |......||.|||.||..|.. ..  ... .     ..|   ||.|.||..  .| ..   |.   .|| |. . ...  ...||  ||.
ndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisvvfGkkevddllkkldidlivrahe

LVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFNDA
...|||...|| .||||.||| |. .  |.....  ...
vseeGyaflfdkrlvtvfsapyysgedtnlgavvvvsks
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 44-278 4e-56 183.2 In-house 40-278 (290) alignment 
Range on Protein: 44-278
Range on HMM: 40-278/290.0
PVSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIXMGDXVDRGYYSXETFTRLLTLKAKFPDRIVLXRGNHESXQITQVYGFYDECQTKYgNANAWRYC
 | .|... ||||||. .| . |   |. |.  .. .|| ||||  | |    |. .| ... .. | |||||  .. ..|||..|   |  ... |.  
eveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrkvnrlygfkeelarkr.gsrlwkqy

TKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIXQIXMIERA--QEIPHKGAFCDLVWSDPDN--VETWAIS-PRGAGWLFGXKVTNXFVHXNNLKLICXAH
 .||. |.. | .....||.|||.|.....   .  ...   .   ..|   ||.|.||..   .| |.   |.   .|| |. . ...   |.||  ||
qdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqraisvvfgkkglddllkklalslivrah

QLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFNDA
.. .||....||.|||||.||| |. .  |. .|.   ..
evkeegfnflfdkklvtvfsapyysgndtnlgaiatvses
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 44-294 2.1e-53 174.5 In-house 44-295 (307) alignment 
Range on Protein: 44-294
Range on HMM: 44-295/307.0
PVSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIXMGDXVDRGYYSXETFTRLLTLKAKFPDRIVLXRGNHESXQITQVYGFYDECQTKYGN--ANAWR
 .  |. | ||.|||| || ..|   |. |.| |.  || ||||  | |.   |.| |  .|. ||| |||||  .. . ||||.|| |   .   . | 
didppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygfyeecvtsipkcgeeiwa

YCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIXQIXMIERAQEIPHKGAFCDLVWSDPDN-VETWAISPRGAGWLFGXKVTNXFVHXNNLKLICXAHQL
   ..|. | |.|.|  ..||.|||||| .  . ..    .    | .|   |..|.|||  |  |  | ||.|. || .| .  ..   ..||  |||.
lfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgtnviddvckrlgveliirahqm

VQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFNDatTREAKLFRNVPDSER
. .||  .   ||.|..||| ||    |   .|  ..  |   .|   ||.|| 
cfdgywvlsgrklitifsapmycnfyknagcvlkvde..tlgiqlvafvpesen
subfamily_PPP5C_pd Subfamily PPP5C 45-290 8.1e-72 234.9 In-house 63-310 (322) alignment 
Range on Protein: 45-290
Range on HMM: 63-310/322.0
VSTPVTVCGDIHGQFYDLEELFRTGGQI-PDTSYIXMGDXVDRGYYSXETFTRLLTLKAKFPDRIVLXRGNHESXQITQVYGFYDECQTKYGNaNAWRYC
 .. .||||||||||||| ..|.  |.  .. .|.  || |||| .| |.   ||..|  .|... | |||||| .. ..||| .|...|| . .     
etkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnklyGfegevkakyte.kvadlf

TKVFDLLTIAAIIDEQVLCVHGGL-SPDVKTIXQIXMIERAQEIPHKGAFCDLVWSDPDNVETWAISPRGAGWLFGXKVTNXFVHXNNLKLICXAHQLVQ
|.||. | .| .|.|.|| ||||| | |  |. ..  |.| .. |..|....|.||||.. .  . | || |  ||  ||. |.. |||.||  .|.. .
tevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqeanGrspskrGvgvqfGpdvtkkflkennleliirshevke

EGYKYMFDDKLVTVWSAPNYCYRCGNIASILAF-NDATTREAKLFRNVP
|||. . | ||.||.|||||| . || .... . .| .. . | |  |.
eGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfktfeave
subfamily_PPP7C_pd Subfamily PPP7C 45-183 2.3e-30 98.6 In-house 62-202 (383) alignment 
Range on Protein: 45-183
Range on HMM: 62-202/383.0
VSTPVTVCGDIHGQFYDLEELF-RTGGQIPDTSYIXMGDXVDRGYYSXETFTRLLTLKAKFPDRIVLXRGNHESXQITQVYGFYDECQTKY--GNANAWR
.|  ||||||.||.. ||  .. . |   .. .|.  || ||||  | |    ||.|   .|  . | |||||   .   |||  | ..||   ...  |
iskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilr

YCTKVFDLLTIAAIIDEQVLCVHGGLSpDVKTIXQIXMIERA
   .||  | .|..|||..| ||||.| |   .  .  ||| 
lledvfawlplatlidekilivhGGis.dktdlelldkiers
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 46-277 1.3e-44 145.9 In-house 6-244 (263) alignment 
Range on Protein: 46-277
Range on HMM: 6-244/263.0
STPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIXMGDXVDRGYYSXETFTRLLTLKAKFPDRIVLXRGNHESXQITQVYGFYDECQTKYGNANA----WR
 .|. .||| |||. ||  .| . |    | |. .|| |||| .| |    |..||  .| .. | |||||   | . |||. | . ..   .     . 
qapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesvyn

YCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIXQIXMIERAQEIPHK-GAFCDLVWSDPDNvETWAISP---RGAGWLFGXKVTNXFVHXNNLKLICXA
.  .||  . ..||. ...||.|||.|| .|.. .|  |    |  .     |||.|.||.. ..  . |   |    .|| |  . ...  .. ||  |
hfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpek.dakgfepnkiraisnvfgkkevddlckrldidlivra

HQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFND
||.|. || .. | .|.||.||  |     | |...  | 
hqvveygyaffadrrlitvfsasryqielcnyaavvvvnk
Metallophos Calcineurin-like phosphoesterase 48-240 8.4e-41 133.4 Pfam-A 2-198 (200) alignment 
Range on Protein: 48-240
Range on HMM: 2-198/200.0
PVTVCGDIHGQFYDL----EELFRTGGQIPDTSYIXMGDXVDRGYYSXETFTRL--LTLKAKFPDRIVLXRGNHESXQITQVYGFYDECQ----------
...|.||.||...||    ..|.. ... . . .. .|| |||| .| ||. .|  | || ..|....| |||||| .....|||..|.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

-----------------------TKYGNANAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIXQIxmieraqeiphkgafcdlvwsdpdnvetwai
                       ..... .|.... ..|..| ..|..| ..|..||.||.. ..  .|                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

sprgAGWLFGXKVTNXFVHXNNLKLICXAHQL
    ...||| .... .   ....|.. .|. 
....gselfgpdalekllekygvdlvlrGHtH
PPP_2 49-240 8.8e-74 240.5 In-house 1-197 (198) alignment 
Range on Protein: 49-240
Range on HMM: 1-197/198.0
VTVCGDIHGQFYDLEELFRTGGQIPDTSYIXMGDXVDRGYYSXETFTRLLTLKAKFPDRIVLXRGNHESXQITQVYGFYDECQTKYGNANAWRYCTKVFD
||||||.|||..|| .||..|...|...|. .|| ||||..| |... ||.|| ..|....| |||||| ....||||..|...|.|..........||.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

LLTIAAIIDEQVLCVHGGLSPDVKTIXQIXMIERAQEIPHKGAFCDL-----VWSDPDNVETWAISPRGAGWLFGXKVTNXFVHXNNLKLICXAHQL
||..||.|||.||.||||||...|.. ||  .|| .|.|..|...||     ....... |..| | ||||.||| .||. ... |.||||. ||..
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 49-240 5.9e-70 228.3 In-house 1-196 (197) alignment 
Range on Protein: 49-240
Range on HMM: 1-196/197.0
VTVCGDIHGQFYDL-EELFRTGGQIP-DTSYIXMGDXVDRGYYSXETFTRLLTLKAKFPDRIVLXRGNHESXQITQVYGFYDECQTKyGNANAWRYCTKV
|||.||||||..||  .|...||. . ..||. .|| ||||..| |... || || ..|...|| |||||| .....|||..|...|  ..........|
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.hgkeilkklqdv

FDLLTIAAIIDEQVLCVHGGLSPDVKTIXQIXMIERAQEIP-HKGAFCDLV-WSDPD-NVETWAISPRGAGWLFGXKVTNXFVHXNNLKLICXAHQL
||||..||.|||.||.||||||...... .|  |||..|.| ......||  ||||  . |..| | ||||.||| .||. |.. ||||||. .|.|
fdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 49-240 5.9e-69 225.0 In-house 1-198 (199) alignment 
Range on Protein: 49-240
Range on HMM: 1-198/199.0
VTVCGDIHGQFYDL-EELFRTGGQIP-DTSYIXMGDXVDRGYYSXETFTRLLTLKAKFPDRIVLXRGNHESXQITQVYGFYDECQTKYGNANAWRYCTKV
||||||.|||..||  .||..||. . ...|. .|| ||||..| |... || || ..|....| |||||. |....|||..|...||...........|
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDLLTIAAIIDEQVLCVHGGLSPDVKTIXQIXMIERAQEIP-HKGAFCDLV-WSDPD-NVET-WAISPRGAGWLFGXKVTNXFVHXNNLKLICXAHQL
|| |..||.|||.||.|||||||..|.| ..  |||..||| .||  .||. ||||  ..|. .. | ||||.||| .||. |.. ||||||. .|.|
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshel
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 75-287 2.8e-62 203.7 In-house 101-313 (317) alignment 
Range on Protein: 75-287
Range on HMM: 101-313/317.0
TSYIXMGDXVDRGYYSXETFTRLLTLKAKFPDRIVLXRGNHESXQITQVYGFYDECQTKYGNaNAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTI
  |. .|| |||| .| |  . |..|| ..||...| ||||||  . . |||| |.. .| . . .    ..|  | ..|......||.|||.| ..  .
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysa.alyeafqlafnvlplcavvnkkilcmhGGiseelldl

XQIXMIERAQEIPHKGAFCDLVWSDPDN-VETWAISPRGAGWLFGXKVTNXFVHXNNLKLICXAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASIL
 |.  ..|  .||  |  .||.|.|||. |.... |.|||| .|| |  . |..  .|.|.  |||.|..||... | ||||..|||.|| .  |||..|
kqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavl

AFNDATTREAKLFR
  ..  .   ...|
svdkklkisinvlr
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 76-287 4.5e-49 160.4 In-house 121-332 (339) alignment 
Range on Protein: 76-287
Range on HMM: 121-332/339.0
SYIXMGDXVDRGYYSXETFTRLLTLKAKFPDRIVLXRGNHESXQITQVYGFYDECQTKYgNANAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIX
 |. .|| |||| .| |    | .||  .|||| | ||||||  .   |||| | . .| .|. .    ..|... ..|.|.. ..|.|||.|  . .. 
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyry.daqlyecfqnmfnvfpfcavinntimcmhggisehltsfn

QIXMIERAQEIPHKGAFCDLVWSDPDNVET-WAISPRGAGWLFGXKVTNXFVHXNNLKLICXAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILA
|. ...|  |||  | . || |.|||  |  .  | ||| ..||      |..  .|...   ||.|..||...   .|||..|||||| .  | |....
qfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfs

FNDATTREAKLFR
 .       ..||
idkklkisinvfr
subfamily_PPP7C_pd Subfamily PPP7C 193-279 2.6e-16 52.3 In-house 238-325 (383) alignment 
Range on Protein: 193-279
Range on HMM: 238-325/383.0
CDLVWSDPDNVE-TWAISPRGAGWLFGXKVTNXFVHXNNLKLICXAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFNDAT
 |..|||| . |  .. . ||.|  ||  ||. ...  ||||.  .|.  .|||... |.|..|..|| ||     |  . . .....
ldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdl