Gene PPP6C-3 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP6C
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP163_AA protein Get Run
SpurP163_AA_1-290 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP2C_pd Subfamily PPP2C 2-285 1.5e-135 444.0 In-house 2-285 (290) alignment 
Range on Protein: 2-285
Range on HMM: 2-285/290.0
SNLDRWIEIAKPCKYLPENDLKKLCDLVCDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIFMGDFVDRGYYSLETFTRLLTLKAKF
..||..||  | || | |...|.||. . ..  .| |||.|..|||||||.||||.|| |||. ||. ||| |.|.||.|||||||.|| | | .|| ..
kdldklieklkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvry

PDRIVLLRGNHESRQITQVYGFYDECQTKYGNANAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIDQIRMIERAQEIPHKGAFCDLVWSDPDNVE
..||..||||||||||||||||||||  |||||| |.| |..|| |...|..|||..|.|||||| ..|.|.|| ..| ||.||.|..|||.|||||. .
keritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddrg

TWAISPRGAGWLFGSKVTNEFVHINNLKLICRAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFNDATTREAKLFRN
 |.|||||||. || .....| . |.|.|| |||||| |||....| ..||..||||||||||| |.|| ..|. ...   |  
gwgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdp
0045823 Metallo-dependent phosphatases 2-290 3.2e-113 371.8 In-house 28-328 (473) alignment 
Range on Protein: 2-290
Range on HMM: 28-328/473.0
SNLDRWIEIAKPCKYLPENDLKKLCDLVCDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIFMGDFVDRGYYSLETFTRLLTLKAKF
..||..||. | ...|||.||.||.| ....  .| |....| ...|.||||||..||..|..  | .|.. ..|.||.||||..|||.. .|| || |.
ldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkiky

PDRIVLLRGNHESRQITQVYGFYDECQTKYgNANAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIDQIRMIERAQEIPHKGAFCDLVWSDPDNVE
|....|||||||.|.....|||.||.  || ... .... .... | .||.|....|.||||||||....||||.||| .|||. |...||.||||....
pgnvfllrGNHElrllnglygfgdetleky.gedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdPwedd

T--------WAISPRGAGWLFGSKVTNEFVHINNLKLICRAHQLVQEGYKYMFDDK------LVTVWSAPNYCYRCGNIASILAFNDATtREAKLFRNVP
         .  ||||||.||| ....|| . |.|.||.|.|. |.|||...||.|      ..||.||||||.|.|| |..| ... . .. ..|. .|
gdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsp

DSE
.  
hpl
0049330 Metallo-dependent phosphatases 2-290 6e-108 353.5 In-house 15-303 (309) alignment 
Range on Protein: 2-290
Range on HMM: 15-303/309.0
SNLDRWIEIAKPCKYLPENDLKKLCDLVCDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIFMGDFVDRGYYSLETFTRLLTLKAKF
|.||..||. . .|.|.|..|..|.. .... ..| |....| ...|.||||||..||..|..  | .|.. ..|.||.||||..|||....|| || ..
slldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalklly

PDRIVLLRGNHESRQITQVYGFYDECQTKYGnANAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIDQIRMIERAQEIPHKGAFCDLVWSDPD-NV
||...|||||||.|.....|||.||.. ||| |. |........ | .||.|....||||||||||....||||..|| .|||. | .|||.||||.  .
pdnvfllrGNHElrllnglygfgdetlrkyg.aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpir

ETWAISPRGAGWLFGSKVTNEFVHINNLKLICRAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFNDATTREAKLFRNVPDSE
|..| .|||.|..||  ....|...|.|.||.|.|..|..||...||.||.||.||||||.|.|| ...| ... .... .||. ||   
egfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvplll
subfamily_PPP6C_pd Subfamily PPP6C 3-291 1.9e-188 617.5 In-house 1-289 (290) alignment 
Range on Protein: 3-291
Range on HMM: 1-289/290.0
NLDRWIEIAKPCKYLPENDLKKLCDLVCDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIFMGDFVDRGYYSLETFTRLLTLKAKFP
.||.|||.|| ||||||||||||||||.||.|||.||||||.||||||||||||||||||||||||.|||||.|.|||||||||||||||||||||||.|
eldkwielakkckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakyp

DRIVLLRGNHESRQITQVYGFYDECQTKYGNANAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIDQIRMIERAQEIPHKGAFCDLVWSDPDNVET
|||.|||||||||||||||||||||..||||||||.||||||||||||||||||||||||||||||||.||||.|||||||||||||||||||||..|||
dritllrgnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpedvet

WAISPRGAGWLFGSKVTNEFVHINNLKLICRAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFNDATTREAKLFRNVPDSER
||.||||||.|||||||.||||||||||||||||||.||.|||||.|||||||||||||||||.|||||..||..||||||..|||.||
wavsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfkavpdeer
subfamily_PPP4C_pd Subfamily PPP4C 3-287 4.9e-146 478.4 In-house 2-286 (288) alignment 
Range on Protein: 3-287
Range on HMM: 2-286/288.0
NLDRWIEIAKPCKYLPENDLKKLCDLVCDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIFMGDFVDRGYYSLETFTRLLTLKAKFP
.||| ||  . |. . |...|.||  . .. .||.||| | .||||||||||||||| |||. ||..|.|.|.|.|||||||.||.|||  ||.||...|
dldrqieklrrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvryp

DRIVLLRGNHESRQITQVYGFYDECQTKYGNANAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIDQIRMIERAQEIPHKGAFCDLVWSDPDNVET
|||.|.|||||||||||||||||||  |||.|| |||||.|||.|..|||||....||||||||...|.|.||.|.| ||.||.|..|||.||||...|.
dritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedaeg

WAISPRGAGWLFGSKVTNEFVHINNLKLICRAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFNDATTREAKLFRNVP
||.||||||.||||.|...|.. |...|||||||||.||||..|..|..||||||||||||||.|.|| ..... .. |.| ...
wavsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaaa
0053225 Metallo-dependent phosphatases 3-287 2.2e-104 341.8 In-house 8-292 (293) alignment 
Range on Protein: 3-287
Range on HMM: 8-292/293.0
NLDRWIEIAKPCKYLPENDLKKLCDLVCDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIFMGDFVDRGYYSLETFTRLLTLKAKFP
.||..||. . .|.|.|..|..|....... ..| |....| ...|.|||||...||..|..  | .|.. ..|.||.||||..|||....|| ||...|
lldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllyp

DRIVLLRGNHESRQITQVYGFYDECQTKYGNANAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIDQIRMIERAQEIPHKGAFCDLVWSDPDNVET
|..||||||||.......|||.||.  |||.|. |........ | .||.|....|.||||||||. ..||||.|.| ..||. |...||.||||| ...
dnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpdlwsg

WAISPRGAGWLFGSKVTNEFVHINNLKLICRAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFNDATTREAKLFRNVP
|..|.||.|..||  .. .|...|.|.||.|.||.|..||...||.|||||.|||||..|.|| ...||... .... |||. |.
wlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapvl
subfamily_PPG1_pd Subfamily PPG1 4-289 1.2e-119 392.1 In-house 1-299 (300) alignment 
Range on Protein: 4-289
Range on HMM: 1-299/300.0
LDRWIEIAKPCKYLPENDLKKLCDLVCDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIFMGDFVDRGYYSLETFTRLLTLKAKFPD
||. .|  . .. |||  .|.|.| . .| ..| ||. . .|||| ||.||||||. |.|. |||.||| |.|.||.||||.||.|| . |..|| ..| 
ldecleklqkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklryps

RIVLLRGNHESRQITQVYGFYDECQTKY-GNANAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIDQIRMIERAQEIPHKGAFCDLVWSDPD----
|| |||||||||||||||||| ||  || ||.. |.| |..|| |..||||||.. ||||||||.|..||||....| .|.|..||..||.||||.    
ritllrgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennn

------NVE--TWAISPRGAGWLFGSKVTNEFVHINNLKLICRAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFNDATTREAKLFRNVPDS
      . |   . .|.||||. .| .|...|.. |... | |||||..|||. .||.|| |||||||||||||| ||||  ..   |  . . . |.|
ptldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeeapes
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 12-276 4.5e-85 278.3 In-house 19-284 (298) alignment 
Range on Protein: 12-276
Range on HMM: 19-284/298.0
KPCKYLPENDLKKLCDLVCDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIFMGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGN
| .| . |.|..||..|. ..  .   .  | .|..||||||||. ||  ||  .|  ||. |.|.||.|||| ..||. . ||. |.|.|....|||||
kltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnffllrGn

HESRQITQVYGFYDECQTKYGNANAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIDQIRMIERAQEIPHKGAFCDLVWSDPDN-VETWAISPRGA
||  .| .|||||.||. .| . . .    .||. | ..|.| ...||.|||||. .|..||.| ..|... ...    ||.|.||.| |. || . ||.
heceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenavkgwaensrGv

GWLFGSKVTNEFVHINNLKLICRAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFNDAT
.  ||..| .....  .. |..||||.||.||... . ||||..|||.|| .  | |...  ..  
svvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdekl
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 14-274 3.6e-69 226.3 In-house 20-283 (297) alignment 
Range on Protein: 14-274
Range on HMM: 20-283/297.0
CKYLPENDLKKLCDLVCDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIFMGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHE
.| . |. . || ||  |.   . ..  | .|. ||||||||| ||  ||. ||  | . |.|.||.|||| .|.||   ||. | |||  ..|||||||
skviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhe

SRQITQVYGFYDECQTKYGNANAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSP---DVKTIDQIRMIERAQEIpHKGAFCDLVWSDPD-NVETWAISPRG
   . .|||||.||| .|     .     ||. | .. .| ...||.||||||   .  |.| .| |||..|  ...  .||.|.||   .  .    ||
cefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisglsgfmenqrg

AGWLFGSKVTNEFVHINNLKLICRAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFND
||  ||     . .   .| |.|||||.||.||...   ||||..||| || .  | |.... ..
agcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscde
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 16-278 3.3e-75 246.2 In-house 7-275 (284) alignment 
Range on Protein: 16-278
Range on HMM: 7-275/284.0
YLPENDLKKLCDLVCDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQI------PDTSYIFMGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLR
 | |..| .||    .|  .|   . . .||...||||||| ||  |.   |         .. |.|.||.|||| .|.|  | |...| ..||...|||
llkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllr

GNHESRQITQVYGFYDECQTKYGNAnAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIDQIRMIERAQEIPHKGAFCDLVWSDPD-NVETWAISPR
|||||| . . |||| ||. .| .|  .      |  . ..|.......|.|||.| |.  ..|.  .||  .||  |  .||.|.||. .||... |||
gnhesrpvnmqygfyleckkrysea.lyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykespr

GAGWLFGSKVTNEFVHINNLKLICRAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFNDATTR
||| .||.|  .||..  .|.|. ||||.|..||... | ||||..||| || .  |||..|  ..    
gagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelva
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 16-67 9.5e-08 24.5 In-house 8-59 (317) alignment 
Range on Protein: 16-67
Range on HMM: 8-59/317.0
YLPENDLKKLCDLVCDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGG
 . |..| .||    .|  .|     . .|||..||||||| ||  |.   |
lfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnG
PPP_3 17-283 1.2e-114 374.9 In-house 2-269 (271) alignment 
Range on Protein: 17-283
Range on HMM: 2-269/271.0
LPENDLKKLCDLVCDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIFMGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQ
|.||.||.|.. . ..  .| |.. .|.|||||||||||..|| |||..||..|.|.|.|.||.||||..|||... ||.|| |.|....||||||||||
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

ITQVYGFYDECQTKYGNANAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIDQIRMIERAQEIPHKGAFCDL-VWSDPDNVETWAISPRGAGWLFG
|..||||..|...|.|... ......||.||..||.|||.||.|||||||..|..|||. .|| .|.|..|...|| ..|||.. |... |.||||.|||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

SKVTNEFVHINNLKLICRAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFNDATTREAKLF
..||.||.. |.||||.|||.|..|||....| |.|||.||||||.|..| ..|| ...|.|.| |..
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkql
subfamily_PPP1C_pd Subfamily PPP1C 17-284 4.8e-97 317.5 In-house 10-277 (282) alignment 
Range on Protein: 17-284
Range on HMM: 10-277/282.0
LPENDLKKLCDLVCDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIFMGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQ
| |.....|..   .. |..  .  .. ||...||||||..||  || |.|  |...|.|.||.||||  |||| . ||..| |.|... |||||||| .
lkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesas

ITQVYGFYDECQTKYGNAnAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIDQIRMIERAQEIPHKGAFCDLVWSDPDN-VETWAISPRGAGWLFG
|...|||||||...|..   |.  |.||. | .||..||..|||||||||..| ..||| |.|  |.|.||  |||.|||||. |..|. . ||  . ||
inriyGfydeckrrysik.lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsftfg

SKVTNEFVHINNLKLICRAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFNDATTREAKLFR
..| ..|.. |.|.||.||||.|..||... . .||||.|||||| . .| ...|. ..  . . ....
kdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilk
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 17-287 1.2e-76 250.8 In-house 24-295 (299) alignment 
Range on Protein: 17-287
Range on HMM: 24-295/299.0
LPENDLKKLCDLVCDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIFMGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQ
. |..|..||..  .  .... .  | .|. ||||||||. ||  .|   |  ||. ..|.||.||||   ||. | ||  | |.|.|. .||||||   
vkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecpa

ITQVYGFYDECQTKYGNANAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIDQIRMIERAQEIPHKGAFCDLVWSDPDN-VETWAISPRGAGWLFG
| .|||||.||. .|  .  |    . |. . .. .|  ..||.|||||| ..|.||.| . | |. |      ||.|.|||. |  |    ||  ..||
inrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgvsyvfg

SKVTNEFVHINNLKLICRAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFNDATTREAKLFRNVP
 .| .. ..  .. |..||||.||.||... . ||||..||| || .  | |.|.  ..      ....  |
qdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptp
subfamily_PPZ_pd Subfamily PPZ 17-274 2.9e-68 223.6 In-house 25-282 (300) alignment 
Range on Protein: 17-274
Range on HMM: 25-282/300.0
LPENDLKKLCDLVCDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIFMGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQ
| .... ..|    .| | . ..  .| .| . ||.|||. ||  ||   |  | . |.|.||.||||  ||||   ||  | |.|. ..|||||||  .
lknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecan

ITQVYGFYDECQTKyGNANAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIDQIRMIERAQEIPHKGAFCDLVWSDP-DNVETWAISPRGAGWLFG
.|.||||||||. .  | . |.     |. | .|||.  ...|||||||| ....|.|| . |  ..|  |   ||.|||| |. . |    ||  . . 
vtrvygfydeckrr.cnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvsycyn

SKVTNEFVHINNLKLICRAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFND
    |.|.    . |.|||| .|..||... |  ||||.||||||    |  .... ..
kvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvse
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 17-274 1.6e-63 207.8 In-house 3-262 (284) alignment 
Range on Protein: 17-274
Range on HMM: 3-262/284.0
LPENDLKKLCDLVCDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIFMGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQ
.| .|.. |   ....  ..  .  | .|. .|||||||| ||  ||   |    . |.|.||.|||| . |||   |.. |  ||.....||||||   
ippedvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecsl

ITQVYGFYDECQTKYGNANAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIDQIRMIERAQEIPHKGAF-CDLVWSDPDNVE-TWAISPRGAGWLF
| ..||||.||| .| .   .     ||  . ..|.. ...||.|||.|  .. . |.| |.|  . |   ..  |..|||| |..  |    ||  ..|
inkiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvf

GSKVTNEFVHINNLKLICRAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFND
||    ...   .. |. ||||.||.||... . .|||..||| || .  | |...  | 
gsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnk
PP2Ac_SM00156 18-285 4.5e-102 333.7 In-house 2-269 (271) alignment 
Range on Protein: 18-285
Range on HMM: 2-269/271.0
PENDLKKLCDLVCDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIFMGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQI
 ......|.. |...  .| |.  ||.||||.||||||..|| .|....|. |.. |.|.||.||||..|.|. . |..|| ..|...|||||||||...
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

TQVYGFYDECQTKYgNANAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIDQIRMIERAQEIPHKGAFCDLVWSDP-DNVETWAISPRGAGWLFGS
...|||..|.. || .....  ....|.||..||..|...||.||||||.....|.|| ..|..|.|..| ..||.|||| ........| ||.. .||.
nkiygfeeevkrky.gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFge

KVTNEFVHINNLKLICRAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFNDATTREAKLFRN
....||.. ||||||.|||..|.|||....| ||||..||||||....| |..| ...... .......
davkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlke
PPP_1 19-270 5.6e-108 353.2 In-house 3-262 (264) alignment 
Range on Protein: 19-270
Range on HMM: 3-262/264.0
ENDLKKLCDLVCDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIFMGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQIT
|. |..|.. . .|  .| |.. ||...||||||||||.|| .||..||. |.|.|.|.||.||||..|.|... ||.|| |.|... ||||||||||.|
eeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvt

QVYGFYDECQTKYGNANAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIDQIRMIERAQEIPHKGAFCDL--------VWSDPDNVETWAISPRGA
.||||..|...|..... ....|.|||.|..||.|||..|.|||||||.....|||| ..| .|.|..|..|||        ...|... |..| |.|||
kvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRGa

GWLFGSKVTNEFVHINNLKLICRAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASIL
|.|||..||..|.. ||||||.|||....|||......|.||..||.||.....| ....
gylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayv
subfamily_PPP3C_pd Subfamily PPP3C 19-275 2.1e-79 260.4 In-house 43-312 (452) alignment 
Range on Protein: 19-275
Range on HMM: 43-312/452.0
ENDLKKLCDLVCDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIFMGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQIT
|..  |. . ...|  .| ..  |..|.||.|||||||||| .||  ||.  .|.|.|.||.|||||.|.|.   |..|| ..|... |||||||.| .|
eeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrhlt

QVYGFYDECQTKYGNaNAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIDQIRMIERAQEIPHKGAFCDLVWSDPDN----V---ET-WAISPRGA
. . | .||..||.. . .  |.. || | .||....| |||||||||..|..|.|. ..| .|.|..|..|||.|||| .        |.    |.|| 
eyftfkeeckikyse.evydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpnsvrGc

GWLFGSKVTNEFVHINNLKLICRAHQLVQEGYKYMFD------DKLVTVWSAPNYCYRCGNIASILAFNDA
 .... | . ||.. |.|  | |||.  ..||.   .        |.|..|||||.    | |..| ... 
syfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyenn
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 19-273 1.3e-72 237.3 In-house 8-262 (280) alignment 
Range on Protein: 19-273
Range on HMM: 8-262/280.0
ENDLKKLCDLVCDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIFMGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQIT
| |.... . . .. . .  .  | .||.||||.|||. ||  ||   .  ||. |.|.||.|||| . ||    ||. |...|.....||||||  .| 
eadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisin

QVYGFYDECQTKYGNAnAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIDQIRMIERAQEIPHKGAFCDLVWSDPD-NVETWAISPRGAGWLFGSK
. |||.||.. .| .|  .    ...| | ..|..  ..||.|||||......|... . |  . ...    ||.|.||. .|  || ..||.  .||..
rkygfkdevkrrysla.lynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifgan

VTNEFVHINNLKLICRAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFN
| .....  .. ||.| ||.||.||... | |||||.|||.|.    | |..|  .
vvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivd
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 19-272 7.8e-52 169.3 In-house 8-286 (302) alignment 
Range on Protein: 19-272
Range on HMM: 8-286/302.0
ENDLKKLCDLVCDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQ-----------IPDTSYIFMGDFVDRGYYSLETFTRLLTLKAKFPDRIVL
...| .|.. | .|  .| ..  .|.|||. ||||||| ||  .. .  .                ..|.||.||||. |.|  . ...||  .| . .|
ksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyil

LRGNHESRQITQVYGFYDECQTKYGNAN---AWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIDQIRMIERA-QEIPHKGAFCDLVWSDPDNVETW
||||||.. |   ||| .| ....|...    |.   .||  . .||.. |..||||||.|| ......|. |.|  .|. .     ||...|| .|.. 
lrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvqll

AISP----------RGAGWLFGSKVTNEFVHINNLKLICRAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAF
|. .          ||   .|     ... .  ||||| |||| . ||.|.. | ||.|..|||.|     |  ..|  
aavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkv
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 19-272 1.1e-51 168.8 In-house 9-287 (302) alignment 
Range on Protein: 19-272
Range on HMM: 9-287/302.0
ENDLKKLCDLVCDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQ-----------IPDTSYIFMGDFVDRGYYSLETFTRLLTLKAKFPDRIVL
...| .|.. | .|  .| ..  .|.|||. ||||||| ||  .. .  .                ..|.||.||||. |.|  . ...||  .| . .|
ksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyil

LRGNHESRQITQVYGFYDECQTKYGNAN---AWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIDQIRMIERA-QEIPHKGAFCDLVWSDPDNVETW
||||||.. |   ||| .| ....|...    |.   .||  . .||.. |..||||||.|| ......|. |.|  .|. .     ||...|| .|.. 
lrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvqll

AISP----------RGAGWLFGSKVTNEFVHINNLKLICRAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAF
|. .          ||   .|     ... .  ||||| |||| . ||.|.. | ||.|..|||.|     |  ..|  
aavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkv
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 21-274 1.9e-67 220.7 In-house 10-263 (280) alignment 
Range on Protein: 21-274
Range on HMM: 10-263/280.0
DLKKLCDLVCDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIFMGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQV
..  .  .|  . .||.|.    .|. | |||| |. |.. ||   |..|.   .|.||.||||   .| .  |. || .. ||| |||||||.  . ..
eiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnki

YGFYDECQTKYGNANAWRYCTkVFDLLTIAAIIDEQVLCVHGGLSPDVKTIDQIRMIERAQEIPHKGAFCDLVWSDPDN-VETWAISPRGAGWLFGSKVT
|||| ||| ||| .  | . . .|. . ....| ..|||.||||||..  .| || | |  |   .| . ||.|||| |  | |  | ||  ..||  | 
ygfyvecqykygvglwwdfqs.cfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkgvv

NEFVHINNLKLICRAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFND
.. ..  .. || ||||.||.||. |   .|.||.| |||| .  | |.....| 
eqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclna
subfamily_PPPLV_pd Subfamily PPPLV 23-271 4.9e-51 166.7 In-house 3-275 (290) alignment 
Range on Protein: 23-271
Range on HMM: 3-275/290.0
KKLCDLVCDLQLEECNVQPVSTPVTVCGDIHGQFYDLE----ELFRTGGQIPDTSYIFMGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQIT
  |||   |  ..| .. .. .|. | ||.||.. ||      |.||| ..  .|..|.||.|||| .|.|  . ||.||  .| ...||||||| . ..
lslcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvq

QVYGFYDECQTKYGNA--NAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIDQIRMIERAQE---IPHKGA--FCDLVWSDPDNVETWA-------
. . .. |.. |.|.   ..|   ..||| | .||.||..|.|||.|.   ..|  .|  |.   |    . .||    |..||||.. .  .       
esieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvl

------ISPRGAGWLFGSKVTNEFVHINNLKLICRAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILA
       . || | .|...  . |.. |||. . |||.  ..|...  . .|.||.|. .||    . | || 
neGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssneaalilv
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 28-289 3.3e-75 245.9 In-house 19-278 (281) alignment 
Range on Protein: 28-289
Range on HMM: 19-278/281.0
LVCDLQLEECNVQPVSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIFMGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYDEC
 |  .  || ..  . .|..| ||.|.|| ||..||   |..|.. ..|.||.||||  |||..  |.||| ...|||||||||||  .. ..|||| ||
eveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvnkiygfyvec

QTKYGNaNAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIDQIRMIERAQEIPHKGAFCDLVWSDPDN-VETWAISPRGAGWLFGSKVTNEFVHIN
.||||  . |    . |. | |.| |...|||.||||||.. ..|..| . .  . ...|   ||.|.|||| || |  | ||....|| .| ..     
vtkyGe.elwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfGknvvddvckrl

NLKLICRAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFNDATtrEAKLFRNVPDS
.. || ||||.||.||. .   ||.||.|.||||    | |..|  ...   . .| . ||.|
eveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetl..gislvalvpas
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 41-291 3.1e-59 193.6 In-house 44-295 (307) alignment 
Range on Protein: 41-291
Range on HMM: 44-295/307.0
PVSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIFMGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYDECQTKYGN--ANAWR
 .  |. | ||.|||| || ..|   |. |.| |.| ||.||||  |||.   |.| |  .|. |||||||||  .. . ||||.|| |   .   . | 
didppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygfyeecvtsipkcgeeiwa

YCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIDQIRMIERAQEIPHKGAFCDLVWSDPDN-VETWAISPRGAGWLFGSKVTNEFVHINNLKLICRAHQL
   ..|. | |.|.|  ..||.|||||| .  .|..|   .    | .|   |..|.|||  |  |  | ||.|. ||..| .. ..   ..|| ||||.
lfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgtnviddvckrlgveliirahqm

VQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFNDatTREAKLFRNVPDSER
. .||  .   ||.|..||| ||    |   .|  ..  |   .|   ||.|| 
cfdgywvlsgrklitifsapmycnfyknagcvlkvde..tlgiqlvafvpesen
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 42-275 3.7e-68 222.5 In-house 35-271 (287) alignment 
Range on Protein: 42-275
Range on HMM: 35-271/287.0
VSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIFMGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYDECQTKYGnANAWRYCT
| .|.|..||||||. ||  .|   |. |.. |.|.||.||||  |||    |..|| ..| .. ||||||| ..| ..|||..| . |..  . ..   
veapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkkinklyGfkeelkrkrq.erlykqfn

KVFDLLTIAAIIDEQVLCVHGGLSPDVKTIDQIRMIERAQEI--PHKGAFCDLVWSDPDN-VETWAIS-PRGAGWLFGSKVTNEFVHINNLKLICRAHQL
.||. |.. |......||.|||.||..|..|... ... .     ..|   ||.|.||..  .| ..   |.   .|| |. .....  ...|| |||..
dvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisvvfGkkevddllkkldidlivrahev

VQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFNDA
..|||...|| .||||.||| |. .  |.....  ...
seeGyaflfdkrlvtvfsapyysgedtnlgavvvvsks
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 42-275 9.2e-62 201.7 In-house 41-278 (290) alignment 
Range on Protein: 42-275
Range on HMM: 41-278/290.0
VSTPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIFMGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYDECQTKYgNANAWRYCT
| .|... ||||||. .| . |   |. |.  ..|.||.||||  |||    |. .| ... .. ||||||| |.. ..|||..|   |  ... |.   
veapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrkvnrlygfkeelarkr.gsrlwkqyq

KVFDLLTIAAIIDEQVLCVHGGLSPDVKTIDQIRMIERA--QEIPHKGAFCDLVWSDPDN--VETWAIS-PRGAGWLFGSKVTNEFVHINNLKLICRAHQ
.||. |.. | .....||.|||.|..... . .. ...   .   ..|   ||.|.||..   .| |.   |.   .|| |. .....   |.|| |||.
dvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqraisvvfgkkglddllkklalslivrahe

LVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFNDA
. .||....||.|||||.||| |. .  |. .|.   ..
vkeegfnflfdkklvtvfsapyysgndtnlgaiatvses
subfamily_PPP7C_pd Subfamily PPP7C 42-181 2.3e-33 108.5 In-house 62-203 (383) alignment 
Range on Protein: 42-181
Range on HMM: 62-203/383.0
VSTPVTVCGDIHGQFYDLEELF-RTGGQIPDTSYIFMGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYDECQTKY--GNANAWR
.|  ||||||.||.. ||  .. . |   .. .|.| |||||||  |.|    ||.|   .|  . | |||||   .   |||  | ..||   ...  |
iskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilr

YCTKVFDLLTIAAIIDEQVLCVHGGLSpDVKTIDQIRMIERAQ
   .||  | .|..|||..| ||||.| |   .. .  ||| .
lledvfawlplatlidekilivhGGis.dktdlelldkiersk
subfamily_PPP5C_pd Subfamily PPP5C 43-287 3.7e-77 252.5 In-house 64-310 (322) alignment 
Range on Protein: 43-287
Range on HMM: 64-310/322.0
STPVTVCGDIHGQFYDLEELFRTGGQI-PDTSYIFMGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYDECQTKYGNaNAWRYCT
.. .||||||||||||| ..|.  |.  .. .|.| ||||||| .|.|.   ||..|  .|... | |||||| .. ..||| .|...|| . .     |
tkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnklyGfegevkakyte.kvadlft

KVFDLLTIAAIIDEQVLCVHGGL-SPDVKTIDQIRMIERAQEIPHKGAFCDLVWSDPDNVETWAISPRGAGWLFGSKVTNEFVHINNLKLICRAHQLVQE
.||. | .| .|.|.|| ||||| | |  |.|..| |.| .. |..|....|.||||.. .  . | || |  ||  ||..|.. |||.|| |.|.. .|
evfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqeanGrspskrGvgvqfGpdvtkkflkennleliirshevkee

GYKYMFDDKLVTVWSAPNYCYRCGNIASILAF-NDATTREAKLFRNVP
||. . | ||.||.|||||| . || .... . .| .. . | |  |.
GyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfktfeave
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 43-274 4.6e-51 167.0 In-house 6-244 (263) alignment 
Range on Protein: 43-274
Range on HMM: 6-244/263.0
STPVTVCGDIHGQFYDLEELFRTGGQIPDTSYIFMGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYDECQTKYGNANA----WR
 .|. .||| |||. ||  .| . |    | |.|.||.|||| .|||    |..||  .| .. ||||||| . | . |||. | . ..   .     . 
qapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesvyn

YCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIDQIRMIERAQEIPHK-GAFCDLVWSDPDNvETWAISP---RGAGWLFGSKVTNEFVHINNLKLICRA
.  .||  . ..||. ...||.|||.|| .|..|.|| |    |  .     |||.|.||.. ..  . |   |    .|| |  .....  .. || ||
hfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpek.dakgfepnkiraisnvfgkkevddlckrldidlivra

HQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFND
||.|. || .. | .|.||.||  |     | |...  | 
hqvveygyaffadrrlitvfsasryqielcnyaavvvvnk
subfamily_YNL217W_pd Subfamily YNL217W 44-116 5.5e-06 19.0 In-house 10-78 (235) alignment 
Range on Protein: 44-116
Range on HMM: 10-78/235.0
TPVTVCGDIHGQFYDLEELFR--TGGQIPDTSYIFMGDFVDRGYYSLETFTRLltlkakFPDRIVLLRGNHESRQ
  . | ||.|| . .| ||.   .||. ..   ...||....|  |.|.   .        |    ..||||   
krllvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelv
Metallophos Calcineurin-like phosphoesterase 45-237 7.7e-46 149.9 Pfam-A 2-198 (200) alignment 
Range on Protein: 45-237
Range on HMM: 2-198/200.0
PVTVCGDIHGQFYDL----EELFRTGGQIPDTSYIFMGDFVDRGYYSLETFTRL--LTLKAKFPDRIVLLRGNHESRQITQVYGFYDECQ----------
...|.||.||...||    ..|.. ... . . ..|.||.|||| .|.||. .|  | || ..|....||||||||......|||..|.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

-----------------------TKYGNANAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTIDQIrmieraqeiphkgafcdlvwsdpdnvetwai
                       ..... .|.... ..|..| ..|..| ..|..||.||.. .. |.|                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

sprgAGWLFGSKVTNEFVHINNLKLICRAHQL
    ...|||.......   ....|..|.|. 
....gselfgpdalekllekygvdlvlrGHtH
PPP_2 46-237 1e-80 263.1 In-house 1-197 (198) alignment 
Range on Protein: 46-237
Range on HMM: 1-197/198.0
VTVCGDIHGQFYDLEELFRTGGQIPDTSYIFMGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYDECQTKYGNANAWRYCTKVFD
||||||.|||..|| .||..|...|...|.|.||.||||..|||... ||.|| ..|....||||||||.....||||..|...|.|..........||.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

LLTIAAIIDEQVLCVHGGLSPDVKTIDQIRMIERAQEIPHKGAFCDL-----VWSDPDNVETWAISPRGAGWLFGSKVTNEFVHINNLKLICRAHQL
||..||.|||.||.||||||...|..|||. .|| .|.|..|...||     ....... |..| | ||||.|||..||.|... |.||||.|||..
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 46-237 3.1e-76 248.8 In-house 1-196 (197) alignment 
Range on Protein: 46-237
Range on HMM: 1-196/197.0
VTVCGDIHGQFYDL-EELFRTGGQIP-DTSYIFMGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYDECQTKyGNANAWRYCTKV
|||.||||||..||  .|...||. . ..||.|.||.||||..|||... || || ..|...|||||||||......|||..|...|  ..........|
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.hgkeilkklqdv

FDLLTIAAIIDEQVLCVHGGLSPDVKTIDQIRMIERAQEIP-HKGAFCDLV-WSDPD-NVETWAISPRGAGWLFGSKVTNEFVHINNLKLICRAHQL
||||..||.|||.||.||||||......|.|. |||..|.| ......||  ||||  . |..| | ||||.|||..||..|.. ||||||.|.|.|
fdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 46-237 8.1e-75 244.2 In-house 1-198 (199) alignment 
Range on Protein: 46-237
Range on HMM: 1-198/199.0
VTVCGDIHGQFYDL-EELFRTGGQIP-DTSYIFMGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYDECQTKYGNANAWRYCTKV
||||||.|||..||  .||..||. . ...|.|.||.||||..|||... || || ..|....|||||||..|....|||..|...||...........|
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDLLTIAAIIDEQVLCVHGGLSPDVKTIDQIRMIERAQEIP-HKGAFCDLV-WSDPD-NVET-WAISPRGAGWLFGSKVTNEFVHINNLKLICRAHQL
|| |..||.|||.||.|||||||..|.|.... |||..||| .||  .||. ||||  ..|. .. | ||||.||| .||..|.. ||||||.|.|.|
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshel
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 72-284 3.6e-68 223.1 In-house 101-313 (317) alignment 
Range on Protein: 72-284
Range on HMM: 101-313/317.0
TSYIFMGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYDECQTKYGNaNAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTI
  |.|.||.|||| .|.|  . |..|| ..||...||||||||| . . |||| |.. .| . . .    ..|  | ..|......||.|||.| ..  .
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysa.alyeafqlafnvlplcavvnkkilcmhGGiseelldl

DQIRMIERAQEIPHKGAFCDLVWSDPDN-VETWAISPRGAGWLFGSKVTNEFVHINNLKLICRAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASIL
.|.  ..|  .||  |  .||.|.|||. |.... |.|||| .||.|  .||..  .|.|. ||||.|..||... | ||||..|||.|| .  |||..|
kqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavl

AFNDATTREAKLFR
  ..  .   ...|
svdkklkisinvlr
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 73-284 1.6e-53 175.0 In-house 121-332 (339) alignment 
Range on Protein: 73-284
Range on HMM: 121-332/339.0
SYIFMGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYDECQTKYgNANAWRYCTKVFDLLTIAAIIDEQVLCVHGGLSPDVKTID
 |.|.||.|||| .|.|    | .||  .|||| ||||||||| .   |||| | . .| .|. .    ..|... ..|.|.. ..|.|||.|  . ...
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyry.daqlyecfqnmfnvfpfcavinntimcmhggisehltsfn

QIRMIERAQEIPHKGAFCDLVWSDPDNVET-WAISPRGAGWLFGSKVTNEFVHINNLKLICRAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILA
|. ...|  |||  | . || |.|||  |  .  | ||| ..||      |..  .|... | ||.|..||...   .|||..|||||| .  | |....
qfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfs

FNDATTREAKLFR
 .       ..||
idkklkisinvfr
subfamily_PPP7C_pd Subfamily PPP7C 190-276 1.6e-17 56.3 In-house 238-325 (383) alignment 
Range on Protein: 190-276
Range on HMM: 238-325/383.0
CDLVWSDPDNVE-TWAISPRGAGWLFGSKVTNEFVHINNLKLICRAHQLVQEGYKYMFDDKLVTVWSAPNYCYRCGNIASILAFNDAT
 |..|||| . |  .. . ||.|  ||. ||.....  ||||. |.|.  .|||... |.|..|..|| ||     |  . . .....
ldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdl