Gene PGAM5 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily PGAM5
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP169_AA protein Get Run
SpurP169_AA_91-281 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0037864 Phosphoglycerate mutase-like 92-272 2.2e-30 98.1 In-house 6-207 (211) alignment 
Range on Protein: 92-272
Range on HMM: 6-207/211.0
ATRHLILIRHGQ--YNTDGI--TDDERILTALGREQAAMTGQRLKALNHPYTTIINSTMARAIETADIISAQIPDI-PRETYCELLRE------------
....|.|.|||.  .|..|.   . .. ||.||||||...|..|. |..|.. .. |.. |||.||.|| ....   .. .... |||            
lmtrlyLvRHGetewnaegrlqgwldvpLtelGreqaralgealadlglpfdavysSpllRaiqTaeiilealglpllpvevdprlrErdfgalegltle

-GAPIPPEPPVGHWKPEVKQFYEDG-------ARIEAAFRKYFHRAdpaQTENSFEVIVCHANVIRYFVCRAMQFPPEAWLRMSLYHGSITWVSIRPsGR
  |   || .| ..   .   ...|       ||...|......|.   . ...  ..|.|..|.|...........|..||. | .||.|.. ... |.
eiaekypeelvawlrdpydfrppggEsladvvaRvlpaleellarl...lkdgenvlvVsHggvlrallayllglsleellrlnlpngsvtvleldd.gg

VSLRAL
. |..|
wvlvsl
subfamily_PGAM5_pd Subfamily PGAM5 93-282 5.7e-106 343.7 In-house 1-189 (189) alignment 
Range on Protein: 93-282
Range on HMM: 1-189/189.0
TRHLILIRHGQYNTDGITDDeRILTALGREQAAMTGQRLKALNHPYTTIINSTMARAIETADIISAQIPDIPRETYCELLREGAPIPPEPPVGHWKPEVK
||||||.|||||..|. .|. .|||.|||.||..||.|||.||...|....|||.||.||||||| |.||.|..|..|||||||||.|||.|.||||| .
trhlilvrhgqyvldddsdk.kiltelGrrqaeltGkrlkelnlkftklvastmvravetadiiskqlpdvpkktktellreGaPikpePavkhwkpeal

QFYEDGARIEAAFRKYFHRADPAQTENSFEVIVCHANVIRYFVCRAMQFPPEAWLRMSLYHGSITWVSIRPSGRVSLRALGDAGFMPANK
||||||||||||||||||||.|.|.|.|.|.||||||||||.||||.|.|||||||.||..||||..|||||||||||.|||.||.||.|
qfyedgarieaafrkyfhraspeqkedsyelivchanvirylvcralqlPpeawlrlslnngsitklsirPsGrvslrelGdvgflPaek
0036777 Phosphoglycerate mutase-like 93-281 1e-32 106.1 In-house 2-238 (247) alignment 
Range on Protein: 93-281
Range on HMM: 2-238/247.0
TRHLILIRHGQ--YNTDGI--TDDERILTALGREQAAMTGQRLKALNHPYTTIINSTMARAIETADIISAQIPDI-PRETYCELLREG------------
...|.|.|||.  .|..|.  .. .. ||.||||||. .|..|| |. |.. .. |.. |||.||.|| ....   .. .... |||             
mkrlyLvRHGetewnaegrfqgwlDvpLtelGreqakalgellkelglpfdavysSpllRAiqTaeiilealglsllpvvvdprLrErdyGalegltkae

--------------APIPPEPPVGHWK-------------------PEVKQFYEDGARIEAAFRKYFHRADpaqTENSFEVIVCHANVIRYFVCRAMQFP
               |... ||. ..                    |.   . .  ||...|......|.     ...  ..|.|..|.|..........
iaekypeelvawwrdpydyrppllelllelllldllryallpldllpggEsladvvaRvlpaleellarll...kdgenvlvVsHggvlrallayllgls

PEAWLRMSLYHGSITWVSIRPSGR-VSLRALGDAGFMPAN
.|..||. | .||||.. ....|  ..|. |.| ..... 
ledilrlnlpngsitvleldddgklwvleslndtshlelg
0043909 Phosphoglycerate mutase-like 93-280 1.8e-32 105.1 In-house 2-242 (249) alignment 
Range on Protein: 93-280
Range on HMM: 2-242/249.0
TRHLILIRHGQYN--TDGI--TDDERILTALGREQAAMTGQRLKALNHPYTTIINSTMARAIETADIISAQIPDI-PRETYCELLREG------------
...|.|.|||.    ..|.  .. .. ||.||||||...|..||.|. |.. .. |.. |||.|| || ....   .  .... |||             
mkrlyLvRHGetewnaegrfqgwlDspLtelGreqaralgealkelgipfdavysSplkRAiqTaeiileelgldklpvevdprLrErdfGalegltkae

-------------------APIPPE------------------PPVGHWKPEVKQFYEDGARIEAAFRKYFHRADpaqTENSFEVIVCHANVIRYFVCRA
                    |.. |                   |  .  |.   . .  ||...|......|..    ...  .||.|..|.|......
iaekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppggEsladvvaRvlpaleellarll...kdggnvliVaHggvlrallayl

MQFPPEAWLRMSLYHGSITWVSIRPSGR--VSLRALGDAGFMPA
.....|..||..| .||||.. . ..|.  |.|. |.| ....|
lglsledilrlnlpngsitvlelddggkpvvvlvllndtshlea
0051064 Phosphoglycerate mutase-like 93-279 3.2e-32 104.8 In-house 3-237 (241) alignment 
Range on Protein: 93-279
Range on HMM: 3-237/241.0
TRHLILIRHGQ--YNTDGITDD--ERILTALGREQAAMTGQRLKALNHPYTTIINSTMARAIETADIISAQIPDI-PRETYCELLREG-------APIP-
...|.|.|||.  .|..|.  .  .. ||.||||||...|.||..|. ... .. |.. |||.||.|| ....   .. .... |||         ... 
mkrlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerladlgikfdavysSpllRaiqTaeiiaealglpllpvvvdprlrEidfgalegltlee

-----PEPPVGHWK--------------------------------PEVKQFYEDGARIEAAFRKYFHRADpaqTENSFEVIVCHANVIRYFVCRAMQFP
     ||  | ..                                 |    . .  ||...|......|.     ...  ..|.|..|||.........|
iaekfpeelvawlrdpldvrppllelldlllllldlryagllddllpggEsladvaaRvlpaleellarll...ldgknvlvVsHggvirallayllglp

PEAWLRMSLYHGSITWVSIRPSG-RVSLRALGDAGFMP
.|..||..| .||.|.. ....| ||.|. |.| ....
leellrlnlpngsvtvleldddgkrvvlvllndtshle
0036887 Phosphoglycerate mutase-like 93-277 3.5e-29 94.2 In-house 1-200 (202) alignment 
Range on Protein: 93-277
Range on HMM: 1-200/202.0
TRHLILIRHGQ--YNTDGITDD--ERILTALGREQAAMTGQRLKalNHPYTTIINSTMARAIETADIISAQIPdIPrETYCELLRE-------------G
...|.|.|||.  .|..|.  .  .. ||.||||||...|.||.  ..|.. .. |.. |||.||.||..... .|  .. . |||              
mtrlyLvRHGetewnvegrlqgdldvpLtelGreqaralgerla..glpfdavysSpllRaiqTaeiiaealg.lp.vivdprlrEidfgalegltleei

APIPPEPPVGHWKPEV-------KQFYEDGARIEAAFRKYFHRAdpaqtENSFEVIVCHANVIRYFVCRAMQFPPEAWLRMS-LYHGSITWVSIrPSGRV
|   ||  . ..   .         . .  ||..||......|.     ...  ..|.|..|.|...........|..||.  | .||.|.... ..|..
aekypeelaawlrdpydfrppggEsladvvaRvlaaleellarl.....dggnvlvVsHggvlrallayllglsledllrlrklpngsvtvlel.ddggw

SLRALGDAGF
.|..|.| ..
vlvllndtsh
0049178 Phosphoglycerate mutase-like 93-278 5.4e-29 94.0 In-house 3-232 (243) alignment 
Range on Protein: 93-278
Range on HMM: 3-232/243.0
TRHLILIRHGQ--YNTDGI--TDDERILTALGREQAAMTGQRLKALNHPYTTIINSTMARAIETADIISAQIPD-IPRETYCELLREG------------
...|.|.|||.  .|..|.  .. .. ||.||||||. .|..|..|... . .. |.. |||.||.|| ....   .. .... |||             
mtrlyLvRHGetewnaegrlqgwtDspLtelGreqAralgellaelglkfdavysSplkRaiqTaeiilealglpllpvvvdprLrErdfGalegltkae

------------------APIPPEPPVGHWK-------------PEVKQFYEDGARIEAAFRKYFHRADpaqTENSFEVIVCHANVIRYFVCRAMQFPPE
                  |..|.  .....              |.   . .  ||...|........     ...  ..|.| .|||........ |.|
iaakypeelvawwrdpydarppalllldlllplldrlladldllpggEsladvaaRvlpaleellaell...hdgktvlvVaHggvirallalllglple

AWLRMSLYHGSITWVSIRPsGRVSLRALGDAGFM
..||. | .||.|.... . |...|..|.| ...
ellrlnlpngsvtvleldd.ggwvlvslndtshl
0053607 Phosphoglycerate mutase-like 94-268 5.1e-29 93.5 In-house 2-183 (191) alignment 
Range on Protein: 94-268
Range on HMM: 2-183/191.0
RHLILIRHGQ--YNTDGITDDERILTALGREQAAMTGQRLKALNHPYTTIINSTMARAIETADIIsaqipDIPrETYCELL-------------REGAPI
..|.|.|||.  .|..|. . .. ||.||||||. ....|..|..... .. |.. ||..||.||     ..|  .... |              | |  
trlyLvRHGetewnaegrlqgdvpLtelGreqaralaellaelglkfdavysSpllRarqTaeii.....glp.vevdprlrEidfgdwegltleelaek

PPEPPVGHWKP-------EVKQFYEDGARIEAAFRKYFHradpaqteNSFEVIVCHANVIRYFVCRAMQFPPEAWLRMSLYHGSITWVSIRPsGRVS
 ||  . ...        .   ...  ||...|......        ..  ..|.|..|||.........|.|..||..| .||.|...... |...
ypeelaawlrdpldyrppggEsladvaaRvlpaleella........ggnvlvVaHggvirallayllglpleellrlnlpngsvtvleldd.ggwv
0047369 Phosphoglycerate mutase-like 94-210 1.3e-07 24.3 In-house 46-219 (438) alignment 
Range on Protein: 94-210
Range on HMM: 46-219/438.0
RHLILIRHGQ------------------YNTDGITDDE-------------RILTALGREQAAMTGQRLKA----LNHPYT-TIINSTMARAIETADIIS
   .|.|||                   .|. ......               || |||||| . |.|| .    ||.. .  .. |.. |....|    
qvqvlfRHGaRtPtksklkkleplwellenattypsgplsflndwlgpcgagqLTplGreqayelGkrlrkrYglLnpedvlyvrssdvdRtlqSAqafl

AQI-PDIPRETYCELLRE----------------GAPIPPEPPVGHWK------PEVKQFYedGARIEAAFRKYFH
| . |.  .. . ..| .                ..|  . | . ...      .|.....   ..| . ..|...
aGlfppegtgelapilwqpipihtipesddfllnllpsdscpafdellkeflasdeflell..lkdilkrlkkllp
0049059 Phosphoglycerate mutase-like 94-211 1.7e-07 23.7 In-house 45-218 (435) alignment 
Range on Protein: 94-211
Range on HMM: 45-218/435.0
RHLILIRHGQ--------------------------------YNTDGITDDeRILTALGREQAAMTGQRLKA-----LNHPYTTIINSTMARAIETADII
.  .|.|||                                  ........   ||.|||||| ..|.|| .     .|.    .. |.. |....|   
qvqvlfRHGaRtPtsklikklealwekllslltypngplsflndwnyplga.geLTplGreqayelGkrlrkrYgfLynpdevyvrssdvdRtlqSaqaf

SAQI--------------------PDIPRETYCELLregaPIPPEPPVGHWK------PEVKQFYedGARIEAAFRKYFHR
 | .                    |   .. .  .|    |  . |   ...      .|.....   .|| . ..... .
laGlfppeilgsqllnplnvyqpvpietvdsdndtl....pydscpafdellkellasdeflelf..lerilkllqellpg
0039931 Phosphoglycerate mutase-like 95-279 3.9e-32 103.8 In-house 1-192 (219) alignment 
Range on Protein: 95-279
Range on HMM: 1-192/219.0
HLILIRHGQ--YNTDGITDDERILTALGREQAAMTGQRLKALNHPYTTIINSTMARAIETADIIsaqipDIPrETYCELLREG-------------APIP
.|.|.|||.  .|..|. .... ||..|||||. .|.||| |. |.. .. |.. |||.||.||     ..|  .... |||              |   
rlyLvRHGetewnvegrlqgdspLterGreqaralgerlkdlglpfdavysSpllRaiqTaeii.....glp.veidprLrEidfgdlegltleeiaeky

PEPPVGHWKPE-------VKQFYEDGARIEAAFRKYFHradpaqteNSFEVIVCHANVIRYFVCRAMQFPPEAWLRMSLYHGSITWVSIRPsGRVSLRAL
||  . ...            . .  ||...|......        ..  ..|.|..|||...........|..||..| .||.|...... |...|. |
peelaawlrdpydyrppggEsladvvaRvlpaleella........genvlvVsHggvirallayllglsleeilrlnlpngsvtvleldd.ggwvlvll

GDAGFMP
.. ....
nltshld
His_Phos_1 Histidine phosphatase superfamily (branch 1) 95-234 3.1e-19 62.4 Pfam-A 1-158 (158) alignment 
Range on Protein: 95-234
Range on HMM: 1-158/158.0
HLILIRHGQ--YNTDGITDDERI--LTALGREQAAMTGQRLKALNHPYTTIINSTMARAIETADIISA--QIPDI----PRETYCEL--LREGAPIPPEP
.|.|.|||.  .|..|. . .    ||. |||||  .|..||. . | . .. |.. |||.||.|...  .|| |     || ...    .  . .. | 
rlylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeldipiikeprLrerdfgeweglpkeevkeef

P--VGHWKP--------EVKQFYEDGARIEAAFRKYFHraDPAQTENSfeVIVCHANVIRYF
|  . .||         |  .. .  .|..........  .  ..||   .||.|..|.| .
peeyekwkrdkkefrppegesladvyeRvapfleelie..akdkgenv..livsHggvlral
His_Phos_1 Histidine phosphatase superfamily (branch 1) 95-234 3.1e-19 62.4 In-house 1-158 (158) alignment 
Range on Protein: 95-234
Range on HMM: 1-158/158.0
HLILIRHGQ--YNTDGITDDERI--LTALGREQAAMTGQRLKALNHPYTTIINSTMARAIETADIISA--QIPDI----PRETYCEL--LREGAPIPPEP
.|.|.|||.  .|..|. . .    ||. |||||  .|..||. . | . .. |.. |||.||.|...  .|| |     || ...    .  . .. | 
rlylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeldipiikeprLrerdfgeweglpkeevkeef

P--VGHWKP--------EVKQFYEDGARIEAAFRKYFHraDPAQTENSfeVIVCHANVIRYF
|  . .||         |  .. .  .|..........  .  ..||   .||.|..|.| .
peeyekwkrdkkefrppegesladvyeRvapfleelie..akdkgenv..livsHggvlral
0053031 Phosphoglycerate mutase-like 95-243 2.3e-08 26.9 In-house 6-193 (342) alignment 
Range on Protein: 95-243
Range on HMM: 6-193/342.0
HLILIRHG----QYNTD-------GITDDERILTALGREQAAMTGQRLKAL---------NHPYTTIINSTMARAIETADIISAQI-PDIPRE-------
  .|.|||    ... .        ....   || |||||| ..|.||. .         |.    .. |.. |....|  . | . |. . .       
vivlvRHGaRtPlskgpldplnewfypcgageLTplGreqayelGrrlrkrYlgllpstynpdevyvrssdvdRtlqSAqaflaGlfppegtpilnpllg

------TYCELLREGAPIPPEPPVGHWK---------PEVKQFYEdgaRIEAAFRKYFHRADpAQTENSFEVIVCHANVIRYFVCRAMQFPP
       ...  ..    |.  |   ..         .|||...|   |... ..|.. . .   . ... ..    . . | ..  ...||
wqpipihtepessdalllpnydpcpafdkllkealaseevkelle...rylellqklskglg.ltlsdlldlvsdlydlllyelahglplpp
0046349 Phosphoglycerate mutase-like 95-180 1.4e-06 20.8 In-house 10-131 (409) alignment 
Range on Protein: 95-180
Range on HMM: 10-131/409.0
HLILIRHGQYN----TDGITDDE-----------RILTALGREQAAMTGQRLKA-------------LNHPYTTIINSTMARAIETADIISAQI-PDIP-
  .|.|||.      .. . ...             ||.|||||| ..|.||..              |.    .  |.. |....|  . | . |.   
vqvlfRHGaRtPtkklsflpnwpginwtngpcgagqLTplGreqayelGkrlrkrYvdlgLlpsnslynpdeiyvrssdvdRtlqSAqaflaGlfpplgg

------RETYCELLREGAPIPP
      | ......  . ||. 
eivpllrqdlldppfqpipidt
subfamily_PGAM_pd Subfamily PGAM 95-159 3.6e-06 18.5 In-house 2-70 (248) alignment 
Range on Protein: 95-159
Range on HMM: 2-70/248.0
HLILIRHGQYNTDGIT----DDERILTALGREQAAMTGQRLKALNHPYTTIINSTMARAIETADIISAQ
.|.|.|||. . .            |.  |.|.|  .|. ||  |  .  .  |.. ||..|...|  .
klvllRhGeselnkenkfcgwvDakLsekGkeeAkkagkalkqanlefdivytSvlkRaqqTlevilee
0049226 Phosphoglycerate mutase-like 95-160 4.1e-06 19.4 In-house 6-91 (342) alignment 
Range on Protein: 95-160
Range on HMM: 6-91/342.0
HLILIRHGQ------YNTD-----GITDDERILTALGREQAAMTGQRLKA---------LNHPYTTIINSTMARAIETADIISAQI
  .|||||       .. |       . .   || |||||| . |.||.          .|.    .  |.. |....|  . | .
vqvliRHGdRtPlakgpldflnewfwgcglgeLTplGreqayelGrrlrkrYlgllpstynpdevyvrssdvdRtlqSaqaflaGl
0035570 Phosphoglycerate mutase-like 96-279 2.6e-32 104.4 In-house 2-194 (219) alignment 
Range on Protein: 96-279
Range on HMM: 2-194/219.0
LILIRHGQ--YNTDGITDDERILTALGREQAAMTGQRLKALNHPYTTIINSTMARAIETADIIsaqipDIPrETYCELLREG-------------APIPP
|.|.|||.  .|..|. .... ||..|||||...|..|..|..|.. .. |.. |||.||.||     ..|  .... |||              |   |
lyLvRHGetewnlegrlqgdvpLterGreqaralgealadlgipfdavysSpllRaiqTaeii.....glp.veidprLrEidfgdlegltldeiaekyp

EPPVGHWKPEVKQFYEDG-------ARIEAAFRKYfhradpaqTENSFEVIVCHANVIRYFVCRAMQFPPEAWLRMSLYHGSITWVSIRPSG-RVSLRAL
|  . ..       . .|       ||...|....         ...  ..|.|..|||.........|.|..||..| .||.|.......| ...|. |
eelaawlrdpydyrppggEsladvvaRvlpaleel........edgenvlvVsHggvirallayllglpleeilrlnlpngsvtvleldggggkwvlvll

GDAGFMP
.| ....
ndtshle
0048955 Phosphoglycerate mutase-like 96-275 1.1e-29 96.4 In-house 3-225 (240) alignment 
Range on Protein: 96-275
Range on HMM: 3-225/240.0
LILIRHGQ--YNTDGITDD--ERILTALGREQAAMTGQRLKALNHPYTTIINSTMARAIETADIISAQIPDI-PRETYCELLREG-------APIP----
|.|.|||.  .|..|.  .   . ||.||||||...|.||..|... . .. |.. |||.||.|| ....   .. .... |||         ...    
lyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerLadlgikfdlvysSpllRaiqTaeiiaealglpllpvvvdprlrErdfgalegltldeiae

--PEPPVGHWK--------------------------------PEVKQFYEDGARIEAAFRKYFHRADPaqtENSFEVIVCHANVIRYFVCRAMQFPPEA
  ||  | ..                                 |.   . .  ||..||......||     ...  ..|.|..|||.........|.|.
kfpeelvlwlrdpldvrppllelldellllldlryalldedllpggEsladvaaRvlaaleellaralk...pgknvlvVsHggvirallayllglplee

WLRMSLYHGSITWVSIRPSgrvsLRALGDA
.||... .||.|.......    |. |.| 
ilrlnipngsvtvlelddg....lvslndt
0050036 Phosphoglycerate mutase-like 96-263 5.1e-21 67.2 In-house 3-169 (171) alignment 
Range on Protein: 96-263
Range on HMM: 3-169/171.0
LILIRHGQYNTD------GITDDEriLTALGREQAAMTGQRLkalnhPYTTIINSTMARAIETADIISaqipdiPRETYCELLRE---------------
|.|.|||.   .      | || .  ||.|||.||. .|..|     |.. .. |.. ||..||..|       .. .. . |||               
lyLvRHGetewnlegrfqgwtdvp..Ltelgraqaralgell.....pfdavysSpllRArqTaelil......lpvivdprLrErdfGawegltldeia

-GAPIPPEPPVGHWKPEVKQFYEDGARIEAAFRKYFhradpaqtenSFEVIVCHANVIRYFVCRAMQFPPEAWLRMSLYHGSITWVSIRP
   |     .. .. |.   ...  ||. .|....           .  ..|.|..|||........ ..|..||. | .||...... .
akypewlldlldlappggEsladvlaRvlpaleell..........gnvlvvaHggvirallalllglsleeilrlelpngsvlvleldd
subfamily_TIGAR_pd Subfamily TIGAR 96-166 6.5e-11 34.3 In-house 3-75 (222) alignment 
Range on Protein: 96-166
Range on HMM: 3-75/222.0
LILIRHGQ--YNTDGITDDE--RILTALGREQAAMTGQRLKalNHPYTTIINSTMARAIETADIISAQIPDIPRE
||..|||.  .|  .|   .    |.  |.|||. ...||.  |.. . |. |   || .||.||  .. .  ||
livVrhGetefnkekilqgqtdtpLsekGveQakrvakrLs..nekinyifsSdllRAkqTaeiilkalkekkre
subfamily_STS_pd Subfamily STS 107-159 1.5e-06 19.8 In-house 47-98 (245) alignment 
Range on Protein: 107-159
Range on HMM: 47-98/245.0
DGITDDERiLTALGREQAAMTGQRLKALNHPYTTIINSTMARAIETADIISAQ
.... |.  ||. |  || ..|..|   .     |. | . | |.||  |  .
kdyksDpP.lterGviqAkllgraLleagikiehifcSPslrciqTaaailkg