Gene ILKAP-1 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily ILKAP
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP180_AA protein Get Run
SpurP180_AA_308-567 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0049733 PP2C-like 309-567 1.6e-50 164.5 In-house 16-233 (235) alignment 
Range on Protein: 309-567
Range on HMM: 16-233/235.0
GTMEDGQTLfssRLSFYAVYDGHSGDKASKHAAKTLHKHIIDTFPKtettNRDKEIKKCLIETFRLTDEEFLKQASASKPVWKDGSTAVCVLVVDNTLYI
 ..||   .    |...||.|||.|  |...|...|...... . .        .....|...|. ..|..|..| ||....  |.|||..|.....||.
kvneDavlv...glllfavaDGhgghaagevasellvetllellle....lllldleealrkaflaaneallelalaspelagmgtTavvalldggklyv

ANLGDSKAFLCRynpetqKHQFLPLSKDHTPTDYDERMRIQKAGSNVrngRVMGILEVSRSIGDGRFKrsgvictPDIKKCQLGDNDrYVLLSCDGLWEG
||.||| |.|.|      . ....|..||.|.. .||.||..||  |   ||.|.| ..|..||  .|       ||.  ..| ..| ..|| .||||. 
anvGDsrayllr......dgklvqltedhspvnelerqriitaggav...rvpgrlaltralGdlllk.......pdvtvlelepgd.flllasDGlwdv

FDAEAVMQFTNDildgENVkqsegkskddvlfETACNRLASEAIRRGSSDNITVILVNI
.. | .... ..     ..             | |..||...|..||. |||||..| .
lsdeeivdllrs....ldl.............eeaaerlvelalarggrDNiTvvvvrl
0034914 PP2C-like 310-567 2.8e-65 212.9 In-house 34-290 (295) alignment 
Range on Protein: 310-567
Range on HMM: 34-290/295.0
TMEDGQTLF------SSRLSFYAVYDGHSGDKASKHAAKTLHKHIIDTFPKT--ETTNRDKEIKKCLIETFRLTDEEFLKQASASKPVWKDGSTAVCVLV
..||  . .       . |....|.|||.|..|...|...|...... . |.   .|. .  |...|...|  .|||.|..| ... ..  |.|||..|.
sneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellelallrpelagsGtTavvali

VDNTLYIANLGDSKAFLCRYNpetqkhQFLPLSKDHTPTDYDERMRIQKAGSNVRNGRVMGILEVSRSIGDGRFK--------RSGVICTPDIKKCQLG-
..|.||.||.|||.|.|.| .      ....|..||.|....||.||..||  |..|||.|.| |.|..|| ..|        . .|...||..  .|. 
rgnklyvanvGDSravllrng......elvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdfdlklllslllleplvsaePdvtvleltl

DNDRYVLLSCDGLWEGFDAEAVMQFTNDIL----DgenvkqsegkskddvlFETACNRLASEAIRRGSSDNITVILVNI
..| ..|| .||||. .. | .... .. |    |                 | |...|. .|..|||.|||||..| .
edddfllLasDGlwdvlsneeivdivrsllakgld................leeaaeeLvdlAlargsrDNiTvvvvrl
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 311-567 9.6e-39 126.2 In-house 20-253 (255) alignment 
Range on Protein: 311-567
Range on HMM: 20-253/255.0
MEDGQTLFS-----SRLSFYAVYDGHSGDKASKHAAKTLHKhIIDTFPKTETTNRdkeiKKCLIETFRLTDEEFlkqasASKPvWKDGSTAVCVLVVDNT
|||  ...      |   .||..|||.|..|.|.|...|.| |.  . . . .|     .|.| .... ..  .     . .|    |.||. ||.... 
medelviyGsfrdksdedyyalfdGhgGraaakfaseelyk.ilaelldlnnanP....vkslkkaykeistqi.....serp.kfiGttaasvliiedk

LYIANLGDSKAFLCrynpeTQKHQFLPLSKDHTPTDYDERMRIQKAGSNVRNG----RVMGILEVSRSIGDGrFKRSGVICTPDIK-KCQLGDNDRYVLL
 ||||.|||.. ||      ..     || || |.. .|. ||...| .| ..    || | | |||..||  |    |.  ||.. . .   .|....|
vyianvGdsrvvlc.....qkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGds.flePfvvpdPdlsqsleiskkdkflil

SCDGLWEGfdaeavmqftndILDGENVKQSEGKSKDdvlfETACNRLASEAIRRGSSDNITVILVNI
.|||.|.             | | | |.   | |.     | |...|   |  .||.|||.||....
acdGiwdl............isdeeaveivagisdp....ekaaeklrdlayssGstdnisvivikl
subfamily_KAPP-like_pd Subfamily KAPP-like 317-566 7.3e-26 83.8 In-house 29-265 (266) alignment 
Range on Protein: 317-566
Range on HMM: 29-265/266.0
LFSSRLSFYAVYDGHSGDKASKHAAKTLHKHIIDTFPKTETTNRDKE---IKKCLIETFRLTDEEFL-----KQASASKPVWKDGstavcvlvVDNTLYI
  .|.....||.|||.|  |.. | | . | . .   .|.  .  ..    .| | ..|.  |...        ...   ||.||            | .
sncsnialfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafkevdaklkdfeyeGatatlalvwsdG........qqrylqv

ANLGDSKAFLCRYNpETqkhqfLPLSKDHTPTDYDERMRIQKAGSNVRNG--RVMGIlEVSRSIGDGRFKR--SGVICTPDIK-KCQLGDNDRYVLLSCD
||.||| |||.| | |.     | |||||  .| .|. ||.. |  . ..  |. |.  |||..||   |.   |.| .| .  .  |   |...... |
anvGdssaflsrGn.es.....lelskdhkakdpeekqrikddGitlsdnqtrinGl.avsralGdhfikelniGlisepyvsnrilltpfdkflivasd

GLWEGFDAEAVMQFTNDILDGENVKQsegkSKDDVLFETACNRLAseairrgSSDNITVILVN
|||.  . .  ..  . . | .. ..    .  . |.||| .          . ||..||.|.
GlwdvisGkdaiekvkslydqqated....kmasslletaiqsik.......akdnvsvivvk
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 317-566 1.3e-23 76.3 In-house 28-275 (276) alignment 
Range on Protein: 317-566
Range on HMM: 28-275/276.0
LFSSRLSFYAVYDGHSGDKASKHAAKTLHKhIIDTFPK------TETTNRD---KEIKKCLIETFRLTDEEF-----LKQASASKPVWKDGSTAVCvlVV
  .|.....||.|||.|  |.. | | . | ..  . |      |.  .      . .| | . |.  |...        ...   ||.||         
sncsnialfavfdGhaGkGaadaakklfpk.elekllksgnysltkqddGGdniydqskllldlfkevdaklkdfeyeGatatlalvwsdGeeqqq..qq

DNTLYIANLGDSKAFLCRYNpETqkhqfLPLSKDHTPTDYDERMRIQKAGSNVRNG--RVMGIlEVSRSIGDGRFKR--SGVICTPDIK-KCQLGDNDRY
.  | .||.||| |||.| | |.     | |||||  || .|. ||.. |  . ..  |. |.  |||..||   |.   |.| .| .  .  |   |..
qrylqvanvGdssaflsrGn.es.....lelskdhkatdpeekqrikddGitlsdnqtrinGl.avsralGdhfikelniGlisepyvsnrilltpfdkf

VLLSCDGLWEGFDAEAVMQFTNDILDGENVKQsegkSKDDVLFETACNRLAseairrgSSDNITVILVN
.... ||||.  . .  ..  . . | .. ..    .  . |.||| .          . ||..||.|.
livasdGlwdvisGkdaiekvkslydqqated....kmasslletaiqsik.......akdnvsvivvk
subfamily_PPM1D_pd Subfamily PPM1D 317-457 3.1e-23 75.3 In-house 30-173 (309) alignment 
Range on Protein: 317-457
Range on HMM: 30-173/309.0
LFSSRLSFYAVYDGHSGDKASKHAAKTLHKHIIDTfpKTETTNRDKEIKKCLIETFRLTDEEFLKQAS-----ASKPVWKDGSTAVCVLVVDNTLYIANL
. .   .| ||.||| | .|.|.| . | . | .   |  ... .... . . |.|  | |.  |. .     .|. .   |.|| .|.. .. ||.|. 
aeelevafvavfDGHGGkeAakfarehlwsvikkq..kkflssepedvleAireaflatheamkkkleeWpktksgllstaGttasvviirreklyvahv

GDSKAFLCRYNPETQKHQFLPLSKDHTPTDYDERMRIQKAGSNVRN
|||...|   .|...| .  .| ||| | . .|. ||...| .| .
GDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaa
subfamily_ILKAP_pd Subfamily ILKAP 318-568 2e-133 437.1 In-house 39-293 (293) alignment 
Range on Protein: 318-568
Range on HMM: 39-293/293.0
FSSRLSFYAVYDGHSGDKASKHAAKTLHKHIIDTFPKTETTNRDKEIKKCLIETFRLTDEEFLKQASASKPVWKDGSTAVCVLVVDNTLYIANLGDSKAF
. ||.|.|||.|||.|..||..||..|||.|....||.......|||||||...|. |||||||.||..||||||||||..|||.||.||.||||||||.
lvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefLklaskakPvWkdGstatvvlvldnvlyvanlGdskav

LCRYNPETQKHQFLPLSKDHTPTDYDERMRIQKAGSNVRNGRVMGILEVSRSIGDGRFKRSGVICTPDIKKCQLGDNDRYVLLSCDGLWEGFDAEAVMQF
|.|...|..|.....|.|||||..|.||.||||||..||.|||.|.||||||||||||||.|||.|||.|||.|..||..|.|.|||||..|.|..|..|
lvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfkrlGvistPdvkkceLtendlfvvlaCdGLwkvfsadevvkf

TNDILDGE----NVKQSEGKSKDDVLFETACNRLASEAIRRGSSDNITVILVNIQ
....|. |    ..|..|.|||..| ||.|||||||||..||||||.||.||.|.
ilkvledeeddrkikeeekkskeevrfevacnrlaseavkrgssdnvtvllvkia
subfamily_PPM1G_pd Subfamily PPM1G 318-382 4.9e-08 25.4 In-house 43-102 (473) alignment 
Range on Protein: 318-382
Range on HMM: 43-102/473.0
FSSRLSFYAVYDGHSGDKASKHAAKTLHKHIidtfpKTETTNRDKEIKKCLIETFRLTDEEFLKQ
. .  |..|||||| | . .|. ||.| . .     | ... .. ...|.| |.|   ||.  ..
ldedtslfavyDGHGGkevakyvakklpdll.....kaqkgykegdvekaleeaflalDeklkae
PP2Cc_SM00332 319-565 2.3e-64 210.5 In-house 37-274 (274) alignment 
Range on Protein: 319-565
Range on HMM: 37-274/274.0
SSRLSFYAVYDGHSGDKASKHAAKTLHKHIIDTFPKTETTNrDKEIKKCLIETFRLTDEEFLKQASASKP-VWKDGSTAVCVLVVDNTLYIANLGDSKAF
... .|..|.|||.|....| ..| |.......  | .... .......| . |. ||||.|.... ...  .. |||||..|.....||.||.|||.|.
eedwlffgvfDGhgGsevakfvskklpealkeelkkkkdel.eddveealkkaflstdeeileeeqskelenalsGstavvallkkedlyvanvGDSrav

LCRYNPetqkhqFLPLSKDHTPTDYDERMRIQKAGSNVRNGRVMGILEVSRSIGDGRFKR------SGVICTPDIKKCQLGDNDRYVLLSCDGLWEGFDA
||| .       ...||.||.| | ||| ||.|||  |..||| | |.|||..||. .|.       .....||.| ..| ..|. ..|..||||. .. 
lcrngk......avqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdhflkknkklkepyitaepdvkvvtltsedeflilaSDGlwdvlsn

EAVMQFTNDILDGEnvkqsegkskDDVLFETACNRLASEAIRR-GSSDNITVILV
. | .. ...|. .           .   . |...|. ||||| ||.|||||..|
qevvdivrkllakg..........ktndpqeaaelldeeairrggseDniTvvvv
subfamily_PPM1E_pd Subfamily PPM1E 319-567 2e-52 171.0 In-house 37-262 (265) alignment 
Range on Protein: 319-567
Range on HMM: 37-262/265.0
SSRLSFYAVYDGHSGDKASKHAAKTLHKHIIDTfpktETTNRDKEikKCLIETFRLTDEEFLKQAsaSKPVWKDGSTAVCVLVVDNTLYIANLGDSKAFL
..  .|.||.|||.| .|.|.||. ||.....     |....| .  . | |.|.||||.||..|   .  .| |||||.||.  ..||.| ||||.|.|
ekeraffavfDGHgGveaakyaaahlhellvrq....eklkedpa..ealkeafkltDerflqka..ereklksGstavvvliekdqlyvaWlGDsqall

CRynpetqKHQFLPLSKDHTPTDYDERMRIQKAGSNVR---NGRVMGILEVSRSIGDGRfKRSGVICTPDIKKCQLGDNDRYVLLSCDGLWEGFDAEAVM
.|      | ... | | | | . ||. ||..||  |    . || |.| |||.||| . ..  |.  .|. ...| ... |..|.|||||. .. | |.
vr......kgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvk.lkpyvsgeadvaeveldgseeylilacDGlwDvvneeevv

QFTNDILDGENVKQSEgkskddvlfetACNRLASEAIRRGSSDNITVILVNI
.  .. |  .. ..||           . . | ..|. .||||||||..| .
klveefladgaedlse...........vakllveaakeagssDnitvvvvfl
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 319-488 3.3e-25 82.2 In-house 17-198 (292) alignment 
Range on Protein: 319-488
Range on HMM: 17-198/292.0
SSRLSF-YAVYDGHS--GDKASKHAAKTLHKHIIDTFPKTETTnrdkeiKKCLIETFRLTDEEFLKqaSASKPVWKDGSTAVCVLVVDN-TLYIANLGDS
|. |.|  ||.|||   ||| .. |..|| .........   .       . |.     .  .. |  .  .   . ....||  | |.  |..||.|||
sealtflaavldGhGvnGdkvaqlaedtlevelleltrqlqel......sealllrildiaakldk..ltidaresattavvcarvrddralilanvGds

KAFLCRYNPeTQKHQFLPLSKDHTPTDYDERMRIQKAGSNVR-----------NGRV------MGILEVSRSIGDGRFKRSGVICTPDIKK
.| | |      ...  |||.|| | | ||| ||..||  |              ||       | | .||..||  .. .||.. |... 
rallgrclg.gsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdfhlfeaGvvaePelqi
PP2C Protein phosphatase 2C 320-560 1.4e-57 188.2 Pfam-A 32-255 (255) alignment 
Range on Protein: 320-560
Range on HMM: 32-255/255.0
SRLSFYAVYDGHSGDKASKHAAKTLHKHIIDTFPKTETTnrdkEIKKCLIETFRL-TDEEFLKQASASkPVWKDGSTAVCVLVVDNTLYIANLGDSKAFL
|. .|.||.||| |..|.| |...|....     ..| .    . .|.|...|.  ||||. ... ..   .| |||||..|.....||.||.|||.| |
ssvaffavfdghggreaakyarehleeilkeqksflele....kvekalrksfladtdeelksskant.epsksGstavvalirgkklyvAnvGDSravL

CRYNPETqkhqfLPLSKDHTPTDYDERMRIQKAGSNVR-NGRVMGILEVSRSIGDGRFKR---SGVICTPDIKKCQLGDNDRYVLLSCDGLWEGFDAEAV
|| . .        |..||.|.| ||| ||..||  |  |||| | |.|||..|| ..|.     |.. ||... .| ..| ...| .||||. .. . .
crkdnak.....keltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpkeeqlvsaePdvtsvklteedefliLasdGlwdvlsdqea

MQFTNDILDGENvkqsegkskddvLFETACNRLASEAIRRGSSDNI
... .. |. ..              ..|...|. |||.|||.|||
vdlvrselskkk............spmeaaeelvdeaiargsedni
PP2C Protein phosphatase 2C 320-560 1.4e-57 188.2 In-house 32-255 (255) alignment 
Range on Protein: 320-560
Range on HMM: 32-255/255.0
SRLSFYAVYDGHSGDKASKHAAKTLHKHIIDTFPKTETTnrdkEIKKCLIETFRL-TDEEFLKQASASkPVWKDGSTAVCVLVVDNTLYIANLGDSKAFL
|. .|.||.||| |..|.| |...|....     ..| .    . .|.|...|.  ||||. ... ..   .| |||||..|.....||.||.|||.| |
ssvaffavfdghggreaakyarehleeilkeqksflele....kvekalrksfladtdeelksskant.epsksGstavvalirgkklyvAnvGDSravL

CRYNPETqkhqfLPLSKDHTPTDYDERMRIQKAGSNVR-NGRVMGILEVSRSIGDGRFKR---SGVICTPDIKKCQLGDNDRYVLLSCDGLWEGFDAEAV
|| . .        |..||.|.| ||| ||..||  |  |||| | |.|||..|| ..|.     |.. ||... .| ..| ...| .||||. .. . .
crkdnak.....keltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpkeeqlvsaePdvtsvklteedefliLasdGlwdvlsdqea

MQFTNDILDGENvkqsegkskddvLFETACNRLASEAIRRGSSDNI
... .. |. ..              ..|...|. |||.|||.|||
vdlvrselskkk............spmeaaeelvdeaiargsedni
PPM_PTC7 320-560 2.9e-55 180.5 In-house 32-259 (259) alignment 
Range on Protein: 320-560
Range on HMM: 32-259/259.0
SRLSFYAVYDGHSGDKASKHAAKTLHKHIIDTFPKTETTnrdkEIKKCLIETFRL--TDEEFLKQASASkPVWKDGSTAVCVLVVDNTLYIANLGDSKAF
.  .|.||.||| |..|.| |...|....     ..|..    . .|.|...|.   ||||. ... ..   .. |||||..|.....||.||.|||.| 
dsvaffavfdghggreaakyarehleeilkerksfeele....klekalrksflaldtdeelksseant.epstsGstAvvalitgsklyvAnvGDSrav

LCRYNPETqkhqfLPLSKDHTPTDYDERMRIQKAGSNVR---NGRVMGILEVSRSIGDGRFKR-----SGVICTPDIKKCQLGDNDRYVLLSCDGLWEGF
||| . .       .|..||.|.. ||| ||..|| .|    |||| | |.|||..|| ..|.       |...|||.. .. ..| ...| .||||. .
Lcrsgnav.....kqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpketeeqlvsaePdisstkideedefliLasdGlwdvv

DAEAVMQFTNDILDGEnvkqsegkskddvLFETACNRLASEAIRRGSSDNI
. . . .. .. |. .               . |...|..|||.|||.|||
sdqeavdlvrselskk.............dpmeaaeklvdeaiargsedni
subfamily_PPM1G2_pd Subfamily PPM1G2 320-567 1.3e-46 151.8 In-house 50-286 (287) alignment 
Range on Protein: 320-567
Range on HMM: 50-286/287.0
SRLSFYAVYDGHSGDKASKHAAKTLHKHIIDtfpktETTNRDKEIKKCLIETFRLTDEEFLKQASASKpvWKDGSTAVCVLVVDNTLYIANLGDSKAFLC
..|...||.||| |.|..|.|.| |.| |        .. .. .....|...|  ||||.||. . ..   . ||||| ||. .. ||.|| |||.| |.
kslalfavfDGhGGakvakyagkklikkiak.....kksfkegaleqilkdafletDeellkdeklkd..esaGstavvvlikeeklyvanaGDsravls

rynpetQKHQFLPLSKDHTPTDYDERMRIQKAGSNVRNGRVMGILEVSRSIGDGRFKRSG--------VICTPDIKKCQLGDNDRYVLLSCDGLWEGFDA
      .| .   || || |.. .|. ||..||  |  .|| | | .||..||  ||..         | ..||.   .| ..| ...|.|||.|. .  
......skgnvkalsfDhkPqeesekkriiaagGfvelnrvngnLalsralgDfefkknvkkkpeeqivtavPDvlvkkldeddeflvLaCDGiWDvltn

EAVMQFTNDILDGEnvKQSEgKSKDDvLFETACNRLASEAiRRGsSDNITVILVNI
. |... .  |  .  .. . .  .. |....... .|..   |  ||.||..| .
kevvdlvrerlvsg..akld.eiiee.lldkclapdssnt.gvG.cDnmtvvivvl
subfamily_PPM1A_pd Subfamily PPM1A 321-568 6.5e-55 179.5 In-house 41-281 (282) alignment 
Range on Protein: 321-568
Range on HMM: 41-281/282.0
RLSFYAVYDGHSGDKASKHAAKTLHKHIIDT--FP-KTETTNRDKEIKKCLIETFRLTDEEFLKQASASKPVWKDGSTAVCVLVVDNTLYIANLGDSKAF
  ||.||.|||.|....|...|.|...|...  .  .... . ..|.|. | . |  .||.  .. . .|   | |||||.||| ...|.|||||||.|.
dwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairelstdlktadksGsTavtvlvsekhliianlGDsRav

LCRYNpetqKHQFlpLSKDHTPTDYDERMRIQKAGSNVRNGRVMGILEVSRSIGDGRFKR--------SGVICTPDIKKCQLGDNDRYVLLSCDGLWEGF
||| .    | .|  |..|| |.. .|. ||..|| .| ..||.| | |||..||  .|.          |.  |... ..  ..| ...|.|||.|.  
lcrng....kaaf..lteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDyeykeeeekkaeeqlvsaepevtsierseeddflvlacDGiwDvl

DAEAVMQFTNDILDGE-NVKQSegkskddvlfetaCNRLASEAIRRGSSDNITVILVNIQ
. | |... .. |.   ....              ...|  .|...|| ||..|..| ..
sdeevvelvrkrlevadeleev.............akalvdkalekgsrDNlsvlvvlfa
subfamily_PPM1L_pd Subfamily PPM1L 321-569 4e-38 124.2 In-house 34-268 (269) alignment 
Range on Protein: 321-569
Range on HMM: 34-268/269.0
RLSFYAVYDGHSGDKASKHAAKTLHKHIIDTFPKTETTNRDKE---IKKCLIETFRLTDEEFLKQASASKPVwkDGSTAVCVLVVDNTLYIANLGDSKAF
  ||.||.||| |. |...| . | | | . . . ..  ...|    .| | .     ||..|..| ... .   |.||.  || .. | .||.|||.  
gesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakraedi..aGttalialvqesdlivanvGdsrGv

LCRYNPETqkhqfLPLSKDHTPTDYDERMRIQKAGSNVR-N--GRVMGILEVSRSIGDGRFKRS-GVICTPDIKKCQLGDN-DRYVLLSCDGLWEGFDAE
|.  . ..     .||| || | .  || ||.|||  .  .   || |.| .||..||  .|    || .|||   .| |   ....|..||||. |  |
lydkrGka.....iplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdknlviadpdiltfdlddhkpeflilasdGlwdtfsne

AVMQFTNDILDGENvkqsegkskddvlFetACNRLASEAIRRGSSDNITVILVNIQK
  ..|  . |.  .             |      |. |. .||| |||||..|....
eavrfikerlkepd.............f..GakslvlesfkrGsvdnitvlvvklkn
subfamily_PPM1K_pd Subfamily PPM1K 321-567 1.8e-31 102.2 In-house 30-258 (263) alignment 
Range on Protein: 321-567
Range on HMM: 30-258/263.0
RLSFYAVYDGHSGDKASKHAAKTLHKHIIDTFpktettNRDKEIKKCLIETFRLTDEEFLKQASA---SKPVWKDGSTAVCVLVVD-NTLYIANLGDSKA
 | ..||.|||.|  | ... . |.|.. . .      ...|.... | ..|   |... . .      .   . |.||  .|. | . | .|.||||.|
ellyvavfdGhaGsaaadfvhdklekilkrll......ekekdleivlknafeeldkklkrylefsvaeaellssGttatvsllrdGtelvlaslGdsra

FLCRyNPETQKhqflpLSKDHTPTDYDERMRIQKAGSNVR-----NGRVMGILEVSRSIGDGRFKRSGVICTPDIKKCQL-GDNDRYVLLSCDGLWEGFD
 ||| | ...|     |..||.|   .|. ||..|| .|      . .| | | ..||.||  .||.||| ||. |. ..  ..| ...|  ||.    .
ilcr.nGkakk.....ltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryGviatPetkslkvdhaadsflvlitdgisfvvn

AEAVmqftndildGENVKQSEGKskddvlfETACNRLASEAIRRGSSDNITVILVNI
 . .         .. |.. .         | | . |.. |.. || || |...| .
sqel.........cdlvrlchdp.......eeaahalteqalqygsednatavvvpl
PPM_PTC7_SpoIIE 323-558 1.2e-25 83.7 In-house 35-228 (230) alignment 
Range on Protein: 323-558
Range on HMM: 35-228/230.0
SFYAVYDGHSGDKaskHAAKTLHKHIIDTFPkTETTNrdkEIKKCLIETFRL--TDEEFLkqasaskpVWKDGSTAVCVLVVDNT--LYIANLGDSKAFL
 .....||| |.    ..| .| . .....  .....   . ...|......  .|.|          ... |.|||..|.  .|  ||.||.||| ..|
lvvgdvdGhGgra...alamgllrtalrela.fagle...kpeeilrrlnlalaadlede........psssgaTavvalidpstgklyvanaGdsppll

CRYNPEtqkhqflplskdhtptdydERMRIqKAGSNVR----NGRVMGILEVSRSIGDGRFKRS-GV-ICTPDIKKCQLGDNDRYVLLSCDGLWEGFDAE
.| ..                    || || .||  ..    .||| | |.||...||  .. . ||  . || .   | ..|... | .||||.. ...
vrddgg...................ereri.vagglpslGilpgrvfgvlavslapGdllllytDGvveaepdtsdgelfgkdeflilasdglwdvlspq

AVMQFTNDILDGEnvkqsegkskddvlfetACNRLASEAIRRGSSD
 ....  | |.                   |...|....|. .. .
elvdlvrdelekp.................aaeglleDDitllvvr
PP2C_SIG_SM00331 323-566 4.8e-14 45.4 In-house 31-216 (217) alignment 
Range on Protein: 323-566
Range on HMM: 31-216/217.0
SFYAVYDGHSGDKASKHAAKTLHKHIIDTFPKTettnrdKEIKKCLIETFRLTDEEflkqasaskPVWKD-GSTAVCVLV--VDNTLYIANLGDSKAFLC
 ...| ||. ...|.  |.. |.. .   . ..      .|... | .. |. .||          . |. . |... |.   ...|..||.|||  .| 
lllvvaDgmGkGlaAaaassqlrtalrellseg......eelsqalkrlnraiyee.........keekgmfaTlllalydfssgklsyanaGdsrpyll

RYNPETQKHQFlplskdhtptdydermriqkagsnvRNGRVMGILEVSRsigdgrfkrsgvictPDIKKCQLGDNDRYVLLScDGLWEG-----FDAEAV
| . .......                          .|...|. . ..               .||.. .|   |...| . |||.|      |. | .
rdgklveilkd.........................vegaplGlepevs...............vdirelelekgdllllyt.DGltearsekgfaeerl

MQFTNDILdgenvkqsegKSKDDVLFETACNRLASEAIRRGSSDNITVILVN
...  | .          .| .. | ..  ..| ..| ... .|.|||..| 
eeiledlv..........dseaqelaqkiveellelakgsngeDdiTvvvvk
PP2C_2 Protein phosphatase 2C 323-525 4.9e-09 28.8 Pfam-A 25-198 (212) alignment 
Range on Protein: 323-525
Range on HMM: 25-198/212.0
SFYAVYDGHSGDKASKHAAKTLHKHIIDTFPKTETTNRDKEIKKCLIETFRLTDEE---FLKQASASKPVWKDGSTAVCVLVVDNTLYIANLGDSKAFLC
.. || ||.. .| |...|. . . ..... |. .... .|... | .. .  ...   . ..... ... . ..| ..... .........||. ... 
wllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavitpgeivffqiGDgaivvr

RYNPETQKhQFLPLSKDHTPTDYDERMRiqKAGSNVrngrvmgilevsrsigdgrfkrsgvictpDIKKCQLGDNdRYVLLSCDGLWEGFD-AEAVMQFT
. . |.|   . | |.... . .  ...  .|....                             .|....| .. . .||. ||.....   |......
drdgevql.lgepdsgeyanettfltse..daeeel.............................rirrlklepg.dalllmTDGvsdslrkeepfrell

NDILDGE
...|.  
aelletl
PP2C_2 Protein phosphatase 2C 323-525 4.9e-09 28.8 In-house 25-198 (212) alignment 
Range on Protein: 323-525
Range on HMM: 25-198/212.0
SFYAVYDGHSGDKASKHAAKTLHKHIIDTFPKTETTNRDKEIKKCLIETFRLTDEE---FLKQASASKPVWKDGSTAVCVLVVDNTLYIANLGDSKAFLC
.. || ||.. .| |...|. . . ..... |. .... .|... | .. .  ...   . ..... ... . ..| ..... .........||. ... 
wllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavitpgeivffqiGDgaivvr

RYNPETQKhQFLPLSKDHTPTDYDERMRiqKAGSNVrngrvmgilevsrsigdgrfkrsgvictpDIKKCQLGDNdRYVLLSCDGLWEGFD-AEAVMQFT
. . |.|   . | |.... . .  ...  .|....                             .|....| .. . .||. ||.....   |......
drdgevql.lgepdsgeyanettfltse..daeeel.............................rirrlklepg.dalllmTDGvsdslrkeepfrell

NDILDGE
...|.  
aelletl
subfamily_PHLPP_pd Subfamily PHLPP 324-514 5.5e-10 31.5 In-house 29-208 (246) alignment 
Range on Protein: 324-514
Range on HMM: 29-208/246.0
FYAVYDGHSGDKASKHAAKTLHKHIIDTFPKTetTNRDKEIKKCLIETFRLTDEEFLKQASASKPVWKDGSTAVCVLVvdNTLYIANLGDSKAFLCRynp
 | ..||.. .. |.   ..... . .   |.  .| .. .|. |. . |   |.  |  ||   .    ...  .     .| .|. |  .| |.|   
lyGlfdGdrneelssllqrlmkdvlkeevqkd..kneeeymkntllvaqrklGeaGeklgsaallilirhdkvdPaks..fsLevAsvGtlqavliR...

eTQKhqFLPLSKDHTpTDYDERMRIQKAGSNVR-NGRVMGILEVSRSIGDgRFKRSGVICTPDIKKCQLGDNDRYVLLSCDGLWEGFDAEAV
  .|   |.||| ..  . ||  ||..| . .  .... |..| .| .|   |    |. .| ... .| ..| ....  . ||| .. . .
.ngk..klrlsksyv.iekdelkrikeakaiitednkingviestrllGy.tflfPvvlPkphvrevlLteqdellivGnkalWevlsidea
subfamily_TAB1_pd Subfamily TAB1 324-382 1.7e-06 20.1 In-house 29-85 (333) alignment 
Range on Protein: 324-382
Range on HMM: 29-85/333.0
FYAVYDGHSGDKASKHAAKTLHKHIIDTFpkTETTNRDKEIKKCLIETFRLTDEEFLKQ
 |||.||. |.||.| ....|  ...       ..  . |.|. | . |  ....||..
lyavFdGydGnkaakfveqrLvaellleq..ltdelaeaevkevlkrafeeverkfles
subfamily_PPM1H_pd Subfamily PPM1H 359-451 3.1e-12 39.0 In-house 131-213 (404) alignment 
Range on Protein: 359-451
Range on HMM: 131-213/404.0
NRDKEIKKCLIETFRLTDEEFLKQASASKpvWKDGSTAVCVLVVDNTLYIANLGDSKAFLCrynpetQKHQFLPLSKDHTPTdyDERMRIQKA
.... ..  | . |   ||   .. .| .   | | ||. .||... ||.|| |||.| |.      .|..  |||.|.||    || |.|. 
skeeLviGalesaflemDeqiarereayr..ikGGCtalvalvllgklYvanaGDsRailv......rkdeiiplsadftPe..teRqRlqel
subfamily_PDP_pd Subfamily PDP 364-478 1.8e-16 53.2 In-house 115-243 (398) alignment 
Range on Protein: 364-478
Range on HMM: 115-243/398.0
IKKCLIETFRLTDEEFLKQAS--ASK-------PVWKDGSTAVCVLVVDNTLYIANLGDSKAFLCRYNPETQkHQFLPLSKDHTPTDYDERMRIQKAG--
.|. | ..|   |... ..|   ...        |   |..|...|. ...|..|| ||..| |.. ..|..  .  .||||.| .  .|  ||.|.   
vkealkkaFlklDkdistealkklkekslreallvalsGacallaliegtelhvAntGDcravlgvqeeegs.weavkLskdqtadneeEveRikkeHPg

----SNVRNGRVMGILEVSRSIGDGRFKRS
    . .||||..| |  .|  || |.| |
eesktvirngRlLgeLqPlRAFGdvryKws
subfamily_PPM1G_pd Subfamily PPM1G 391-568 3.2e-32 105.2 In-house 295-471 (473) alignment 
Range on Protein: 391-568
Range on HMM: 295-471/473.0
KDGSTAVCVLVVDNTLYIANLGDSKAFLCRYnpetqkHQFLPLSKDHTPTDYDERMRIQKAGSNVR-NGRVMGILEVSRSIGDGRFKRSG--------VI
. |.||| .|. ...|..|| |||.. |.|        . | || || | |  |. ||.||| .|  .||| | | .|| .||  .|.          . 
dsGttAvvaLlkekklivAnaGDsRcvlsrn......GkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplkeqmis

CTPDIKKCQLGDNDRYVLLSCDGLWEGFDAEAVMQFTNDILDgeNVKQSegkSKDDVLFETACNRLASEAIRRGS-SDNITVILVNIQ
  ||||. .| ..| .. | |||.|   ... |..| .. |   ....|   .  ... |   . ||..    |.  || |||.| ..
AlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklk..kgees...vlseiveeLlDaclapdtsgDGtGCDnmtviivllk
subfamily_TAB1_pd Subfamily TAB1 391-477 1.5e-16 53.2 In-house 128-214 (333) alignment 
Range on Protein: 391-477
Range on HMM: 128-214/333.0
KDGSTAVCVLVVDNTLYIANLGDSKAFLCRYNPetqKHQFLPLSKDHTPTDYDERMRIQKAGSN---VRNGRVMGILEVSRSIGDGRFKR
..|.||| .|.. | ||.|| |||.| |.. ..   ....  ||.|||    || .|... | .   ... ...|  |  ||||| . | 
sgGttAvvalifnnkLyVaNvGdsrAllvkrke...sekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkk
subfamily_Choan-PPM-1_pd Subfamily Choan-PPM-1 392-516 6.1e-06 17.6 In-house 134-276 (317) alignment 
Range on Protein: 392-516
Range on HMM: 134-276/317.0
DGSTAVCVLVVDNTLY-IANLGDSKAF--LCRYNPETQK--HQFLPLSKDHTPTDYDERMRIQKAG---SNVRNGRVMGI---------LEVSRSIGDGR
 |.|||  .|||.| . .|| ||. |.  | . . . ..   .   ||. ||    .|| |....    . | .   . |         | ...|.|  .
fGttavvavvvdethvvvanaGdaaalvllrdqaghedrdGlsvealsvrhtlrskaerarvaevlpgaahvtedgylaildealaayelqltkslGhkl

FKRSGVICTPDIKKCQLGDNDRYVLLS-CDGLWEGFDAEAVMQ
.|| |||  |...   |  .. . ..   ||. ...  . |. 
lkraGviadPevrsrvldvdevfavvvvsdGitdelkrldvld
subfamily_PP2D1_pd Subfamily PP2D1 397-529 1.4e-22 73.1 In-house 181-320 (492) alignment 
Range on Protein: 397-529
Range on HMM: 181-320/492.0
VCVLVVDNTLYIANLGDSKAFLCRYnpETQKHqflpLSKDHTPTDYDERMRIQKAGS----NVRNGRVMGILEVSRS---IGDGRFKRSgVICTPDIKKC
   |..  .||||| |. .| |||      ..    | ..||| .  || |..||||    . .||.| |||.. |    .||.. |.| ||. | ..  
evhleelgvlyianaGnvqAvLcre..Gkaii....LtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdpkLkks.vipePkttsv

QLGDNDRYVLLSCDGLWEGFDAEAVMQFTNDILDG-------ENVKQ
.| ... ...|   |||| ...| |..  ...|         ||| .
kldeaaqflvlAsnGlWevlseeevlsLvkqtlaiyksrvraenvpd
Subfamily Dicty-PPM1L-like 443-567 7.2e-12 37.7 In-house 181-303 (305) alignment 
Range on Protein: 443-567
Range on HMM: 181-303/305.0
DERMRIQKAGSNVRNG---RVMGILEVSRSIGDGRFKRSgVICTPDIKKCQLG-DNDRYVLLSCDGLWEGFDAEAVMQFTNDILDgenVKQSEGKSKDDv
..|.||. ... . |    .| ..|..|||.||.  |   ||  .| .   .   || ...|. ||||| .. . | .. ...|     |.|..| . | 
eiririeslqaalynygellvnrllkksrskGdknlkel.viPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellr...dkssqkkiewd.

lFETACNRLASEAIRRGSSDNITVILVNI
 |.   .. . ||..||| ||||.... .
.fneisrviveeavkrgsgDnitlviikl
subfamily_PPM1D_pd Subfamily PPM1D 464-568 3.5e-09 29.2 In-house 201-308 (309) alignment 
Range on Protein: 464-568
Range on HMM: 201-308/309.0
LEVSRSIGD-----GRFKRSGVICTPDIKKCQLGD-NDRYVLLSCDGLWEGFDAEAVMQFTNDILDGENVKQSEGKSKDDVLFETACNRLASEAIRrgsS
| |.||.||      . ..  |   ||.|. .|   ......|. ||||.   .|..... ..    . .|.....|   .| ..| .| .|. .|   .
LavaRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklr...a

DNITVILVNIQ
||..||.| ..
Dnvsvivvile
subfamily_PDP_pd Subfamily PDP 481-549 2e-08 26.7 In-house 271-339 (398) alignment 
Range on Protein: 481-549
Range on HMM: 271-339/398.0
ICTPDIKKCQLGDNDRYVLLSCDGLWEGFDAEAVMQFTNDILDGENVKQSEGKSKDDVLFETACNRLAS
. .|.. . .|. ||....|. ||||. .. |.|..  .. |.... |.. . .. .. ...  ..|. 
taePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkkekepvkveeakltlkqvveelke