Gene ILKAP-2 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily ILKAP
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP181_AA protein Get Run
SpurP181_AA_68-354 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0034914 PP2C-like 69-354 3e-69 226.0 In-house 16-287 (295) alignment 
Range on Protein: 69-354
Range on HMM: 16-287/295.0
TGMYSLHGYYAERKGERNEMQDKHVILNDFTPQFSNlpstvsrLSFYAVYDGHSGDKASKHAAKMLHKHILDRFPKT--ETTNRDKEIKKCLIETFRVTD
.  ..|. ..|  .| |....| .... .. .....       |....|.|||.|..|...|...|....|. . |.   .|. .  |...|...|  .|
slllllrvgvasdqGrrksneDavlvvlnllslled.......lllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaad

EEFLKQASASKPVWKDGSTAVCVLVVDNTLYIANLGDSKAFLCRYNpetqkhQFLPLSKDHTPTDYDERMRIQKAGSNVRNGRVMGILEVSRSIGDGRFK
||.|..| ... ..  |.|||..|...|.||.||.|||.|.|.| .      ....|..||.|....||.||..||  |..|||.|.| |.|..|| ..|
eellelallrpelagsGtTavvalirgnklyvanvGDSravllrng......elvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdfdlk

--------RSGVICTPDIKKCQLG-DNDRYILLSCDGLWEGFEADAVMQFTNDIL----DgekvkqsegkskddvlFETACNRLASEAIRRGSSDNITVI
        . .|...||..  .|. ..| ..|| .||||. .. . .... .. |    |                 | |...|. .|..|||.|||||.
lllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgld................leeaaeeLvdlAlargsrDNiTvv

L
.
v
subfamily_ILKAP_pd Subfamily ILKAP 71-354 2e-148 486.2 In-house 2-289 (293) alignment 
Range on Protein: 71-354
Range on HMM: 2-289/293.0
MYSLHGYYAERKGERNEMQDKHVILNDFTPQFSNLPSTVSRLSFYAVYDGHSGDKASKHAAKMLHKHILDRFPKTETTNRDKEIKKCLIETFRVTDEEFL
.|.|.|.||||||||.||||.||||.|...| ..  |.|||.|.|||.|||.|..||..||..|||.||...||.......|||||||...|. ||||||
lyklkgayaerkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefL

KQASASKPVWKDGSTAVCVLVVDNTLYIANLGDSKAFLCRYNPETQKHQFLPLSKDHTPTDYDERMRIQKAGSNVRNGRVMGILEVSRSIGDGRFKRSGV
|.||..||||||||||..|||.||.||.||||||||.|.|...|..|.....|.|||||..|.||.||||||..||.|||.|.||||||||||||||.||
klaskakPvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfkrlGv

ICTPDIKKCQLGDNDRYILLSCDGLWEGFEADAVMQFTNDILDGE----KVKQSEGKSKDDVLFETACNRLASEAIRRGSSDNITVIL
|.|||.|||.|..||....|.|||||..|.||.|..|....|. |    |.|..|.|||..| ||.|||||||||..||||||.||.|
istPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrkikeeekkskeevrfevacnrlaseavkrgssdnvtvll
PP2Cc_SM00332 75-353 6.7e-68 222.0 In-house 12-272 (274) alignment 
Range on Protein: 75-353
Range on HMM: 12-272/274.0
HGYyAERKGERNEMQDKHVILNDFTpqfsnlpsTVSRLSFYAVYDGHSGDKASKHAAKMLHKHILDRFPKTETTNrDKEIKKCLIETFRVTDEEFLKQAS
.|. .. .|.|..|.| ||. .|.           .. .|..|.|||.|....| ..| |.... ..  | .... .......| . |. ||||.|....
ygk.ssmqgwrksmeDahvvvvdlv........eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdel.eddveealkkaflstdeeileeeq

ASKP-VWKDGSTAVCVLVVDNTLYIANLGDSKAFLCRYNPetqkhqFLPLSKDHTPTDYDERMRIQKAGSNVRNGRVMGILEVSRSIGDGRFKR------
 ...  .. |||||..|.....||.||.|||.|.||| .       ...||.||.| | ||| ||.|||  |..||| | |.|||..||. .|.      
skelenalsGstavvallkkedlyvanvGDSravlcrngk......avqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdhflkknkklke

SGVICTPDIKKCQLGDNDRYILLSCDGLWEGFEADAVMQFTNDILDGEkvkqsegkskDDVLFETACNRLASEAIRR-GSSDNITVI
 .....||.| ..| ..|. ..|..||||. .. . | .. ...|. .           .   . |...|. ||||| ||.|||||.
pyitaepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakg..........ktndpqeaaelldeeairrggseDniTvv
0049733 PP2C-like 76-354 1.4e-51 168.0 In-house 5-230 (235) alignment 
Range on Protein: 76-354
Range on HMM: 5-230/235.0
GYYAERKGE-RNEMQDKHVIlndftpqfsnlpstvsRLSFYAVYDGHSGDKASKHAAKMLHKHILDRFPKtettNRDKEIKKCLIETFRVTDEEFLKQAS
 ..| ..|  |....| ...                 |...||.|||.|  |...|...|....|. . .        .....|...|. ..|..|..| 
vgaasdigrvrkvneDavlv................glllfavaDGhgghaagevasellvetllellle....lllldleealrkaflaaneallelal

ASKPVWKDGSTAVCVLVVDNTLYIANLGDSKAFLCRynpetqKHQFLPLSKDHTPTDYDERMRIQKAGSNVrngRVMGILEVSRSIGDGRFKrsgvictP
||....  |.|||..|.....||.||.||| |.|.|      . ....|..||.|.. .||.||..||  |   ||.|.| ..|..||  .|       |
aspelagmgtTavvalldggklyvanvGDsrayllr......dgklvqltedhspvnelerqriitaggav...rvpgrlaltralGdlllk.......p

DIKKCQLGDNDrYILLSCDGLWEGFEADAVMQFTNDilD-GekvkqsegkskddvlfETACNRLASEAIRRGSSDNITVIL
|.  ..| ..| ..|| .||||. .. . .... ..  .                  | |..||...|..||. |||||..
dvtvlelepgd.flllasDGlwdvlsdeeivdllrs..ldl................eeaaerlvelalarggrDNiTvvv
subfamily_PPM1A_pd Subfamily PPM1A 79-354 1.7e-56 184.7 In-house 17-277 (282) alignment 
Range on Protein: 79-354
Range on HMM: 17-277/282.0
AERKGERNEMQDKHVILNDFtpqfsnlPsTVSRLSFYAVYDGHSGDKASKHAAKMLHKHILD--RFP-KTETTNRDKEIKKCLIETFRVTDEEFLKQASA
.. .| |.|| |.|..  ..       . ...  ||.||.|||.|....|...|.|...||.  ..  .... . ..|.|. | . |  .||.  .. . 
ssmqgwrvemEDahtvvasl.......g.alkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairelstd

SKPVWKDGSTAVCVLVVDNTLYIANLGDSKAFLCRYNpetqKHQFlpLSKDHTPTDYDERMRIQKAGSNVRNGRVMGILEVSRSIGDGRFKR--------
.|   | |||||.||| ...|.|||||||.|.||| .    | .|  |..|| |.. .|. ||..|| .| ..||.| | |||..||  .|.        
lktadksGsTavtvlvsekhliianlGDsRavlcrng....kaaf..lteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDyeykeeeekkaee

SGVICTPDIKKCQLGDNDRYILLSCDGLWEGFEADAVMQFTNDILDGEKVKQ-SegkskddvlfetaCNRLASEAIRRGSSDNITVIL
  |.  |... ..  ..| ...|.|||.|.  . . |... .. |.  .  .               ...|  .|...|| ||..|..
qlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleev.............akalvdkalekgsrDNlsvlv
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 79-353 7e-40 129.9 In-house 11-249 (255) alignment 
Range on Protein: 79-353
Range on HMM: 11-249/255.0
AERKGERNEMQDKHVILNDFTPQFSNlpstvsrlSFYAVYDGHSGDKASKHAAKMLHKhILDRFPKTETTNRdkeiKKCLIETFRVTDEEFlkqasASKP
..  | |. |.|. ||   |  .  .         .||..|||.|..|.|.|.. |.| ||  . . . .|     .|.| .... ..  .     . .|
sdmiGrrptmedelviyGsfrdksde........dyyalfdGhgGraaakfaseelyk.ilaelldlnnanP....vkslkkaykeistqi.....serp

vWKDGSTAVCVLVVDNTLYIANLGDSKAFLCrynpeTQKHQFLPLSKDHTPTDYDERMRIQKAGSNVRNG----RVMGILEVSRSIGDGrFKRSGVICTP
    |.||. ||....  ||||.|||.. ||      ..     || || |.. .|. ||...| .| ..    || | | |||..||  |    |.  |
.kfiGttaasvliiedkvyianvGdsrvvlc.....qkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGds.flePfvvpdP

DIK-KCQLGDNDRYILLSCDGLWEgfeadavmqftnDILDGEKVKQSEGKSKDdvlfETACNRLASEAIRRGSSDNITVI
|.. . .   .|....|.|||.|.             | | | |.   | |.     | |...|   |  .||.|||.||
dlsqsleiskkdkflilacdGiwd............lisdeeaveivagisdp....ekaaeklrdlayssGstdnisvi
subfamily_PPM1E_pd Subfamily PPM1E 81-353 6e-57 185.8 In-house 11-258 (265) alignment 
Range on Protein: 81-353
Range on HMM: 11-258/265.0
RKGERNEMQDKHVILNDFTPQFSNlpSTVSRLSFYAVYDGHSGDKASKHAAKMLHKHILDRFPKTETTNrdkeikKCLIETFRVTDEEFLKQAsaSKPVW
 |..|  | |.||.|.|.   |    .  .  .|.||.|||.| .|.|.||. ||... ..   .| .       . | |.|..|||.||..|   .  .
vknkrrkmEDrhvaledlnelfel..kdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa......ealkeafkltDerflqka..erekl

KDGSTAVCVLVVDNTLYIANLGDSKAFLCRynpetqKHQFLPLSKDHTPTDYDERMRIQKAGSNVR---NGRVMGILEVSRSIGDGRfKRSGVICTPDIK
| |||||.||.  ..||.| ||||.|.|.|      | ... | | | | . ||. ||..||  |    . || |.| |||.||| . ..  |.  .|. 
ksGstavvvliekdqlyvaWlGDsqallvr......kgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvk.lkpyvsgeadva

KCQLGDNDRYILLSCDGLWEGFEADAVMQFTNDILDGEKVKQSEgkskddvlfetACNRLASEAIRRGSSDNITVI
...| ... |..|.|||||. .. . |..  .. |  .. ..||           . . | ..|. .||||||||.
eveldgseeylilacDGlwDvvneeevvklveefladgaedlse...........vakllveaakeagssDnitvv
subfamily_PPM1D_pd Subfamily PPM1D 81-248 4.2e-26 84.8 In-house 9-174 (309) alignment 
Range on Protein: 81-248
Range on HMM: 9-174/309.0
RKGERNEMQDKHVILNDFTPQFSnlpstVSRLSFYAVYDGHSGDKASKHAAKMLHKHILDRfpKTETTNRDKEIKKCLIETFRVTDEEFLKQAS-----A
..|.|. |.|  .|  . ...           .| ||.||| | .|.|.| . | . | ..  |  ... .... . . |.|  | |.  |. .     .
dqGgrkymeDvvaivleeeesae.....elevafvavfDGHGGkeAakfarehlwsvikkq..kkflssepedvleAireaflatheamkkkleeWpktk

SKPVWKDGSTAVCVLVVDNTLYIANLGDSKAFLCRYNPETQKHQFLPLSKDHTPTDYDERMRIQKAGSNVRNG
|. .   |.|| .|.. .. ||.|. |||...|   .|...| .  .| ||| | . .|. ||...| .| . 
sgllstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaak
subfamily_PPM1G_pd Subfamily PPM1G 81-172 2.9e-09 29.4 In-house 26-102 (473) alignment 
Range on Protein: 81-172
Range on HMM: 26-102/473.0
RKGERNEMQDKHVILNDFTpqfsnlpstvSRLSFYAVYDGHSGDKASKHAAKMLHKHIldrfpKTETTNRDKEIKKCLIETFRVTDEEFLKQ
 .| |... | |  . |..          .  |..|||||| | . .|. ||.| . .     | ... .. ...|.| |.|   ||.  ..
mqGwrvsqEDahncitdld..........edtslfavyDGHGGkevakyvakklpdll.....kaqkgykegdvekaleeaflalDeklkae
PP2C Protein phosphatase 2C 82-350 1.1e-60 198.3 Pfam-A 9-255 (255) alignment 
Range on Protein: 82-350
Range on HMM: 9-255/255.0
KGERNEMQDKHVILNDFTPQfsnlpSTVSRLSFYAVYDGHSGDKASKHAAKMLHKHILDRFPKTETTnrdkEIKKCLIETFRV-TDEEFLKQASASkPVW
.| | .| |.|..|...  .     |  |. .|.||.||| |..|.| |...|....  .  ..| .    . .|.|...|.  ||||. ... ..   .
qgarksmedahialknleks.....sgkssvaffavfdghggreaakyarehleeilkeqksflele....kvekalrksfladtdeelksskant.eps

KDGSTAVCVLVVDNTLYIANLGDSKAFLCRYNPETqkhqfLPLSKDHTPTDYDERMRIQKAGSNVR-NGRVMGILEVSRSIGDGRFKR---SGVICTPDI
| |||||..|.....||.||.|||.| ||| . .        |..||.|.| ||| ||..||  |  |||| | |.|||..|| ..|.     |.. ||.
ksGstavvalirgkklyvAnvGDSravLcrkdnak.....keltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpkeeqlvsaePdv

KKCQLGDNDRYILLSCDGLWEGFEADAVMQFTNDILDGEKvkqsegkskddvLFETACNRLASEAIRRGSSDNI
.. .| ..| ...| .||||. .. . .... .. |. .|              ..|...|. |||.|||.|||
tsvklteedefliLasdGlwdvlsdqeavdlvrselskkk............spmeaaeelvdeaiargsedni
PP2C Protein phosphatase 2C 82-350 1.1e-60 198.3 In-house 9-255 (255) alignment 
Range on Protein: 82-350
Range on HMM: 9-255/255.0
KGERNEMQDKHVILNDFTPQfsnlpSTVSRLSFYAVYDGHSGDKASKHAAKMLHKHILDRFPKTETTnrdkEIKKCLIETFRV-TDEEFLKQASASkPVW
.| | .| |.|..|...  .     |  |. .|.||.||| |..|.| |...|....  .  ..| .    . .|.|...|.  ||||. ... ..   .
qgarksmedahialknleks.....sgkssvaffavfdghggreaakyarehleeilkeqksflele....kvekalrksfladtdeelksskant.eps

KDGSTAVCVLVVDNTLYIANLGDSKAFLCRYNPETqkhqfLPLSKDHTPTDYDERMRIQKAGSNVR-NGRVMGILEVSRSIGDGRFKR---SGVICTPDI
| |||||..|.....||.||.|||.| ||| . .        |..||.|.| ||| ||..||  |  |||| | |.|||..|| ..|.     |.. ||.
ksGstavvalirgkklyvAnvGDSravLcrkdnak.....keltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpkeeqlvsaePdv

KKCQLGDNDRYILLSCDGLWEGFEADAVMQFTNDILDGEKvkqsegkskddvLFETACNRLASEAIRRGSSDNI
.. .| ..| ...| .||||. .. . .... .. |. .|              ..|...|. |||.|||.|||
tsvklteedefliLasdGlwdvlsdqeavdlvrselskkk............spmeaaeelvdeaiargsedni
PPM_PTC7 82-350 7.3e-58 189.0 In-house 9-259 (259) alignment 
Range on Protein: 82-350
Range on HMM: 9-259/259.0
KGERNEMQDKHVILNDFTPQfsnlpSTVSRLSFYAVYDGHSGDKASKHAAKMLHKHILDRFPKTETTnrdkEIKKCLIETFRV--TDEEFLKQASASkPV
.| | .| |.|..|...  .     |  .  .|.||.||| |..|.| |...|....  |  ..|..    . .|.|...|.   ||||. ... ..   
qgfrksmedahialanless.....sgkdsvaffavfdghggreaakyarehleeilkerksfeele....klekalrksflaldtdeelksseant.ep

WKDGSTAVCVLVVDNTLYIANLGDSKAFLCRYNPETqkhqfLPLSKDHTPTDYDERMRIQKAGSNVR---NGRVMGILEVSRSIGDGRFKR-----SGVI
.. |||||..|.....||.||.|||.| ||| . .       .|..||.|.. ||| ||..|| .|    |||| | |.|||..|| ..|.       |.
stsGstAvvalitgsklyvAnvGDSravLcrsgnav.....kqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpketeeqlvs

CTPDIKKCQLGDNDRYILLSCDGLWEGFEADAVMQFTNDILDGEkvkqsegkskddvLFETACNRLASEAIRRGSSDNI
..|||.. .. ..| ...| .||||. .. . . .. .. |. .               . |...|..|||.|||.|||
aePdisstkideedefliLasdGlwdvvsdqeavdlvrselskk.............dpmeaaeklvdeaiargsedni
subfamily_PPM1G2_pd Subfamily PPM1G2 82-353 2.7e-48 157.4 In-house 27-282 (287) alignment 
Range on Protein: 82-353
Range on HMM: 27-282/287.0
KGERNEMQDKHVILNDftpqFSNLPSTvSRLSFYAVYDGHSGDKASKHAAKMLHKHILDrfpktETTNRDKEIKKCLIETFRVTDEEFLKQASASKpvWK
.| | .| | |.. |.    . ... . ..|...||.||| |.|..|.|.| |.| |        .. .. .....|...|  ||||.||. . ..   .
qGyrlnmeDahilene....lleksdd.kslalfavfDGhGGakvakyagkklikkiak.....kksfkegaleqilkdafletDeellkdeklkd..es

DGSTAVCVLVVDNTLYIANLGDSKAFLCrynpetQKHQFLPLSKDHTPTDYDERMRIQKAGSNVRNGRVMGILEVSRSIGDGRFKRSG--------VICT
 ||||| ||. .. ||.|| |||.| |.      .| .   || || |.. .|. ||..||  |  .|| | | .||..||  ||..         | ..
aGstavvvlikeeklyvanaGDsravls......skgnvkalsfDhkPqeesekkriiaagGfvelnrvngnLalsralgDfefkknvkkkpeeqivtav

PDIKKCQLGDNDRYILLSCDGLWEGFEADAVMQFTNDILDGEKVKQsegKSKDDvLFETACNRLASEAiRRGsSDNITVI
||.   .| ..| ...|.|||.|. .. . |... .  |  ..  .   .  .. |....... .|..   |  ||.||.
PDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgakld...eiiee.lldkclapdssnt.gvG.cDnmtvv
subfamily_PPM1L_pd Subfamily PPM1L 82-353 9.8e-39 126.2 In-house 13-262 (269) alignment 
Range on Protein: 82-353
Range on HMM: 13-262/269.0
KGERNEMQDKHVILNDFTPQfsnlpstvSRLSFYAVYDGHSGDKASKHAAKMLHKHILDRFPKTETTNRDKE---IKKCLIETFRVTDEEFLKQASASKP
.| |..|.|.  | .| . .           ||.||.||| |. |...| ..| | |.... . ..  ...|    .| | .     ||..|..| ... 
lGrrprmedrfeieediknk........tgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakraed

VwkDGSTAVCVLVVDNTLYIANLGDSKAFLCRYNPETqkhqfLPLSKDHTPTDYDERMRIQKAGSNVR-N--GRVMGILEVSRSIGDGRFKRS-GVICTP
.   |.||.  || .. | .||.|||.  |.  . ..     .||| || | .  || ||.|||  .  .   || |.| .||..||  .|    || .|
i..aGttalialvqesdlivanvGdsrGvlydkrGka.....iplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdknlviadp

DIKKCQLGDN-DRYILLSCDGLWEGFEADAVMQFTNDILDgekvkQSEgkskddvlFetACNRLASEAIRRGSSDNITVI
||   .| |   ....|..||||. |  .  ..|  . |.     . .        |      |. |. .||| |||||.
diltfdlddhkpeflilasdGlwdtfsneeavrfikerlk.....epd........f..GakslvlesfkrGsvdnitvl
PPM_PTC7_SpoIIE 83-349 8e-28 90.8 In-house 10-229 (230) alignment 
Range on Protein: 83-349
Range on HMM: 10-229/230.0
GERNEMQDKHVILNDFTPQfsnlpSTVSRLSFYAVYDGHSGDKasKHAAKMLHkHILDRFPkTETTNrdkEIKKCLIETFRV--TDEEFLkqasaskpVW
| | .| |.|......        |  .   .....||| |.   . |...|.  .|...  .....   . ...|.....   .|.|          ..
garksmedahispanseks.....sggrlalvvgdvdGhGgra..alamgllr.talrela.fagle...kpeeilrrlnlalaadlede........ps

KDGSTAVCVLVVDNT--LYIANLGDSKAFLCRYNPEtqkhqflplskdhtptdydERMRIqKAGSNVR----NGRVMGILEVSRSIGDGRFKRS-G-VIC
. |.|||..|.  .|  ||.||.||| ..|.| ..                    || || .||  ..    .||| | |.||...||  .. . | | .
ssgaTavvalidpstgklyvanaGdsppllvrddgg...................ereri.vagglpslGilpgrvfgvlavslapGdllllytDGvvea

TPDIKKCQLGDNDRYILLSCDGLWEGFEADAVMQFTNDILDGEkvkqsegkskddvlfetACNRLASEAIRRGSSDN
 || .   | ..|... | .||||.. ... ....  | |.                   |...|....|. .. ..
epdtsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp.................aaeglleDDitllvvrv
subfamily_PP2D1_pd Subfamily PP2D1 86-145 2.2e-07 23.0 In-house 15-66 (492) alignment 
Range on Protein: 86-145
Range on HMM: 15-66/492.0
NEMQDKHVILNDFTPQFSNlpstvsrlSFYAVYDGHSGDKASKHAAKMLHKHILDRFPKT
 .|.||... ..|...  .        .|...|||. |  | . ||| ||. .|..  | 
skmeDkrtlqdyfgndvns........cFfgiyDGynGataAeiaakelhevlleelekv
subfamily_KAPP-like_pd Subfamily KAPP-like 106-353 8.8e-27 86.8 In-house 28-262 (266) alignment 
Range on Protein: 106-353
Range on HMM: 28-262/266.0
PSTVSRLSFYAVYDGHSGDKASKHAAKMLHKHILDRFPKTETTNRDKE---IKKCLIETFRVTDEEFLK----QASA-SKPVWKDGstavcvlvVDNTLY
 | .|.....||.|||.|  |.. | |.. | . .   .|.  .  ..    .| | ..|.  |... .     |.|    ||.||            | 
lsncsnialfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafkevdaklkdfeyeGatatlalvwsdG........qqrylq

IANLGDSKAFLCRYNpETqkhqfLPLSKDHTPTDYDERMRIQKAGSNVRNG--RVMGIlEVSRSIGDGRFKR--SGVICTPDIK-KCQLGDNDRYILLSC
.||.||| |||.| | |.     | |||||  .| .|. ||.. |  . ..  |. |.  |||..||   |.   |.| .| .  .  |   |...... 
vanvGdssaflsrGn.es.....lelskdhkakdpeekqrikddGitlsdnqtrinGl.avsralGdhfikelniGlisepyvsnrilltpfdkflivas

DGLWEGFEADAVMQFTNDILDGEKVKQSegksKDDVLFETACNRLAseairrgSSDNITVI
||||.  . .  ..  . . | .. ...      . |.||| .          . ||..||
dGlwdvisGkdaiekvkslydqqatedk....masslletaiqsik.......akdnvsvi
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 106-336 4.3e-24 77.8 In-house 27-262 (276) alignment 
Range on Protein: 106-336
Range on HMM: 27-262/276.0
PSTVSRLSFYAVYDGHSGDKASKHAAKMLHKHILDRFPK-----TETTNRD---KEIKKCLIETFRVTDEEFLK-----QASASKPVWKDGSTAVCvlVV
 | .|.....||.|||.|  |.. | |.. | ..  .       |.  .      . .| | . |.  |... .      ...   ||.||         
lsncsnialfavfdGhaGkGaadaakklfpkelekllksgnysltkqddGGdniydqskllldlfkevdaklkdfeyeGatatlalvwsdGeeqqq..qq

DNTLYIANLGDSKAFLCRYNpETqkhqfLPLSKDHTPTDYDERMRIQKAGSNVRNG--RVMGIlEVSRSIGDGRFKR--SGVICTPDIK-KCQLGDNDRY
.  | .||.||| |||.| | |.     | |||||  || .|. ||.. |  . ..  |. |.  |||..||   |.   |.| .| .  .  |   |..
qrylqvanvGdssaflsrGn.es.....lelskdhkatdpeekqrikddGitlsdnqtrinGl.avsralGdhfikelniGlisepyvsnrilltpfdkf

ILLSCDGLWEGFEADAVMQFTNDILDGEKVKQSegksKDDVLFETACNR
.... ||||.  . .  ..  . . | .. ...      . |.||| . 
livasdGlwdvisGkdaiekvkslydqqatedk....masslletaiqs
subfamily_PHLPP_pd Subfamily PHLPP 109-305 3.4e-11 35.5 In-house 24-209 (246) alignment 
Range on Protein: 109-305
Range on HMM: 24-209/246.0
VSRLSFYAVYDGHSGDKASKHAAKMLHKHILDRFPKTetTNRDKEIKKCLIETFRVTDEEFLKQASASKPVWKDGSTAVCVLVvdNTLYIANLGDSKAFL
.|. . | ..||.. .. |.   ..... ...   |.  .| .. .|. |. . |   |.  |  ||   .    ...  .     .| .|. |  .| |
lsvealyGlfdGdrneelssllqrlmkdvlkeevqkd..kneeeymkntllvaqrklGeaGeklgsaallilirhdkvdPaks..fsLevAsvGtlqavl

CRynpeTQKhqFLPLSKDHTpTDYDERMRIQKAGSNVR-NGRVMGILEVSRSIGDgRFKRSGVICTPDIKKCQLGDNDRYILLSCDGLWEGFEADAVM
.|     .|   |.||| ..  . ||  ||..| . .  .... |..| .| .|   |    |. .| ... .| ..| ....  . ||| .. | . 
iR....ngk..klrlsksyv.iekdelkrikeakaiitednkingviestrllGy.tflfPvvlPkphvrevlLteqdellivGnkalWevlsideav
subfamily_PPM1H_pd Subfamily PPM1H 109-144 3.2e-06 19.2 In-house 59-94 (404) alignment 
Range on Protein: 109-144
Range on HMM: 59-94/404.0
VSRLSFYAVYDGHSGDKASKHAAKMLHKHILDRFPK
   | .....|||.|  |.  |.|.||||. ... .
klplayfglfDGhaGsgaalvaskllhkhlkekled
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 110-277 7.2e-25 81.1 In-house 18-197 (292) alignment 
Range on Protein: 110-277
Range on HMM: 18-197/292.0
SRLSF-YAVYDGHS--GDKASKHAAKMLHKHILDRFPKTettnrdKEIKKCLIETFRVTDEEFLKqaSASKPVWKDGSTAVCVLVVDN-TLYIANLGDSK
. |.|  ||.|||   ||| .. |.. | ...|. ...       .|. . |.     .  .. |  .  .   . ....||  | |.  |..||.|||.
ealtflaavldGhGvnGdkvaqlaedtlevelleltrql......qelsealllrildiaakldk..ltidaresattavvcarvrddralilanvGdsr

AFLCRYNPeTQKHQFLPLSKDHTPTDYDERMRIQKAGSNVR-----------NGRV------MGILEVSRSIGDGRFKRSGVICTPDIK
| | |      ...  |||.|| | | ||| ||..||  |              ||       | | .||..||  .. .||.. |...
allgrclg.gsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdfhlfeaGvvaePelq
subfamily_TAB1_pd Subfamily TAB1 111-172 1e-07 24.1 In-house 26-85 (333) alignment 
Range on Protein: 111-172
Range on HMM: 26-85/333.0
RLSFYAVYDGHSGDKASKHAAKMLHKHILDRFpkTETTNRDKEIKKCLIETFRVTDEEFLKQ
    |||.||. |.||.| ....|  ..|       ..  . |.|. | . |  ....||..
dpilyavFdGydGnkaakfveqrLvaellleq..ltdelaeaevkevlkrafeeverkfles
subfamily_PPM1K_pd Subfamily PPM1K 112-315 4.1e-31 101.1 In-house 31-232 (263) alignment 
Range on Protein: 112-315
Range on HMM: 31-232/263.0
LSFYAVYDGHSGDKASKHAAKMLHKHILDRFpktettNRDKEIKKCLIETFRVTDEEFLKQASAS---KPVWKDGSTAVCVLVVD-NTLYIANLGDSKAF
| ..||.|||.|  | ... . |.|.. . .      ...|.... | ..|   |... . .  |   .   . |.||  .|. | . | .|.||||.| 
llyvavfdGhaGsaaadfvhdklekilkrll......ekekdleivlknafeeldkklkrylefsvaeaellssGttatvsllrdGtelvlaslGdsrai

LCRyNPETQKhqflpLSKDHTPTDYDERMRIQKAGSNVR-----NGRVMGILEVSRSIGDGRFKRSGVICTPDIKKCQL-GDNDRYILLSCDGLWEGFEA
||| | ...|     |..||.|   .|. ||..|| .|      . .| | | ..||.||  .||.||| ||. |. ..  ..| ...|  ||.    . 
lcr.nGkakk.....ltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryGviatPetkslkvdhaadsflvlitdgisfvvns

DAVMQFTNDILDGE
  . .. .   | |
qelcdlvrlchdpe
PP2C_2 Protein phosphatase 2C 113-313 7.4e-10 31.5 Pfam-A 25-196 (212) alignment 
Range on Protein: 113-313
Range on HMM: 25-196/212.0
SFYAVYDGHSGDKASKHAAKMLHKHILDRFPKTETTNRDKEIKKCLIETFRVTDEE---FLKQASASKPVWKDGSTAVCVLVVDNTLYIANLGDSKAFLC
.. || ||.. .| |...|... . ..... |. .... .|... | .. .  ...   . ..... ... . ..| ..... .........||. ... 
wllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavitpgeivffqiGDgaivvr

RYNPETQKhQFLPLSKDHTPTDYDERMRiqKAGSNVrngrvmgilevsrsigdgrfkrsgvictpDIKKCQLGDNdRYILLSCDGLWEGFE-ADAVMQFT
. . |.|   . | |.... . .  ...  .|....                             .|....| .. . .||. ||......  .......
drdgevql.lgepdsgeyanettfltse..daeeel.............................rirrlklepg.dalllmTDGvsdslrkeepfrell

NDILD
...|.
aelle
PP2C_2 Protein phosphatase 2C 113-313 7.4e-10 31.5 In-house 25-196 (212) alignment 
Range on Protein: 113-313
Range on HMM: 25-196/212.0
SFYAVYDGHSGDKASKHAAKMLHKHILDRFPKTETTNRDKEIKKCLIETFRVTDEE---FLKQASASKPVWKDGSTAVCVLVVDNTLYIANLGDSKAFLC
.. || ||.. .| |...|... . ..... |. .... .|... | .. .  ...   . ..... ... . ..| ..... .........||. ... 
wllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavitpgeivffqiGDgaivvr

RYNPETQKhQFLPLSKDHTPTDYDERMRiqKAGSNVrngrvmgilevsrsigdgrfkrsgvictpDIKKCQLGDNdRYILLSCDGLWEGFE-ADAVMQFT
. . |.|   . | |.... . .  ...  .|....                             .|....| .. . .||. ||......  .......
drdgevql.lgepdsgeyanettfltse..daeeel.............................rirrlklepg.dalllmTDGvsdslrkeepfrell

NDILD
...|.
aelle
PP2C_SIG_SM00331 114-354 1.9e-14 46.7 In-house 32-214 (217) alignment 
Range on Protein: 114-354
Range on HMM: 32-214/217.0
FYAVYDGHSGDKASKHAAKMLHKHILDRFPKTettnrdKEIKKCLIETFRVTDEEflkqasaskPVWKDGSTAVCVLV---VDNTLYIANLGDSKAFLCR
...| ||. ...|.  |...|.. .   . ..      .|... | .. |. .||          . |.. .......    ...|..||.|||  .| |
llvvaDgmGkGlaAaaassqlrtalrellseg......eelsqalkrlnraiyee.........keekgmfaTlllalydfssgklsyanaGdsrpyllr

YNPETQKHQFlplskdhtptdydermriqkagsnvRNGRVMGILEVSRsigdgrfkrsgvictPDIKKCQLGDNDRYILLScDGLWEGFEADA-----VM
 . .......                          .|...|. . ..               .||.. .|   |...| . |||.|  ...      ..
dgklveilkd.........................vegaplGlepevs...............vdirelelekgdllllyt.DGltearsekgfaeerle

QFTNDILdgekvkqsegKSKDDVLFETACNRLASEAIRRGSSDNITVIL
..  | .          .| .. | ..  ..| ..| ... .|.|||..
eiledlv..........dseaqelaqkiveellelakgsngeDdiTvvv
subfamily_PPM1H_pd Subfamily PPM1H 150-241 1.4e-12 40.1 In-house 132-213 (404) alignment 
Range on Protein: 150-241
Range on HMM: 132-213/404.0
RDKEIKKCLIETFRVTDEEFLKQASASKpvWKDGSTAVCVLVVDNTLYIANLGDSKAFLCrynpetQKHQFLPLSKDHTPTdyDERMRIQKA
... ..  | . |   ||   .. .| .   | | ||. .||... ||.|| |||.| |.      .|..  |||.|.||    || |.|. 
keeLviGalesaflemDeqiarereayr..ikGGCtalvalvllgklYvanaGDsRailv......rkdeiiplsadftPe..teRqRlqel
subfamily_PDP_pd Subfamily PDP 154-268 6.5e-17 54.7 In-house 115-243 (398) alignment 
Range on Protein: 154-268
Range on HMM: 115-243/398.0
IKKCLIETFRVTDEEFLKQAS--ASK-------PVWKDGSTAVCVLVVDNTLYIANLGDSKAFLCRYNPETQkHQFLPLSKDHTPTDYDERMRIQKAG--
.|. | ..|   |... ..|   ...        |   |..|...|. ...|..|| ||..| |.. ..|..  .  .||||.| .  .|  ||.|.   
vkealkkaFlklDkdistealkklkekslreallvalsGacallaliegtelhvAntGDcravlgvqeeegs.weavkLskdqtadneeEveRikkeHPg

----SNVRNGRVMGILEVSRSIGDGRFKRS
    . .||||..| |  .|  || |.| |
eesktvirngRlLgeLqPlRAFGdvryKws
subfamily_PPM1G_pd Subfamily PPM1G 181-324 5.3e-32 104.4 In-house 295-436 (473) alignment 
Range on Protein: 181-324
Range on HMM: 295-436/473.0
KDGSTAVCVLVVDNTLYIANLGDSKAFLCRYnpetqkHQFLPLSKDHTPTDYDERMRIQKAGSNVR-NGRVMGILEVSRSIGDGRFKRSG--------VI
. |.||| .|. ...|..|| |||.. |.|        . | || || | |  |. ||.||| .|  .||| | | .|| .||  .|.          . 
dsGttAvvaLlkekklivAnaGDsRcvlsrn......GkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplkeqmis

CTPDIKKCQLGDNDRYILLSCDGLWEGFEADAVMQFTNDILDGEKVKqsegkS
  ||||. .| ..| .. | |||.|   |.. |..| .. |  .. .     .
AlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgees.....v
subfamily_TAB1_pd Subfamily TAB1 181-297 3.2e-17 55.3 In-house 128-258 (333) alignment 
Range on Protein: 181-297
Range on HMM: 128-258/333.0
KDGSTAVCVLVVDNTLYIANLGDSKAFLCRYNPetqKHQFLPLSKDHTPTDYDERMRIQKAGSN---VRNGRVMGILEVSRSIGDGRFKR----------
..|.||| .|.. | ||.|| |||.| |.. ..   ....  ||.|||    || .|... | .   ... ...|  |  ||||| . |           
sgGttAvvalifnnkLyVaNvGdsrAllvkrke...sekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkkgykdvdilss

---SGVICTPDIKKC-QLGDNDRYILLSCDGLWE
     || .|||.   .. |  ....|  ||. .
akgePviaePdiqgaypiddityflvlmSdGvyk
subfamily_Choan-PPM-1_pd Subfamily Choan-PPM-1 182-306 1.5e-06 19.6 In-house 134-276 (317) alignment 
Range on Protein: 182-306
Range on HMM: 134-276/317.0
DGSTAVCVLVVDNTLY-IANLGDSKAF--LCRYNPETQK--HQFLPLSKDHTPTDYDERMRIQKAG---SNVRNGRVMGI---------LEVSRSIGDGR
 |.|||  .|||.| . .|| ||. |.  | . . . ..   .   ||. ||    .|| |....    . | .   . |         | ...|.|  .
fGttavvavvvdethvvvanaGdaaalvllrdqaghedrdGlsvealsvrhtlrskaerarvaevlpgaahvtedgylaildealaayelqltkslGhkl

FKRSGVICTPDIKKCQLGDNDRYI-LLSCDGLWEGFEADAVMQ
.|| |||  |...   |  .. .  .   ||. .... . |. 
lkraGviadPevrsrvldvdevfavvvvsdGitdelkrldvld
subfamily_PP2D1_pd Subfamily PP2D1 186-318 7.2e-23 74.0 In-house 180-312 (492) alignment 
Range on Protein: 186-318
Range on HMM: 180-312/492.0
AVCVLVVDNTLYIANLGDSKAFLCRYnpETQKHqflpLSKDHTPTDYDERMRIQKAGS----NVRNGRVMGILEVSRS---IGDGRFKRSgVICTPDIKK
    |..  .||||| |. .| |||      ..    | ..||| .  || |..||||    . .||.| |||.. |    .||.. |.| ||. | .. 
sevhleelgvlyianaGnvqAvLcre..Gkaii....LtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdpkLkks.vipePktts

CQLGDNDRYILLSCDGLWEGFEADAVMQFTNDILDGEKVK
 .| ... ...|   |||| .... |..  ...|   | .
vkldeaaqflvlAsnGlWevlseeevlsLvkqtlaiyksr
Subfamily Dicty-PPM1L-like 233-353 4.9e-12 38.3 In-house 181-299 (305) alignment 
Range on Protein: 233-353
Range on HMM: 181-299/305.0
DERMRIQKAGSNVRNG---RVMGILEVSRSIGDGRFKRSgVICTPDIKKCQLG-DNDRYILLSCDGLWEGFEADAVMQFTNDILDgekVKQSEGKSKDDv
..|.||. ... . |    .| ..|..|||.||.  |   ||  .| .   .   || ...|. ||||| .. . | .. ...|     |.|..| . | 
eiririeslqaalynygellvnrllkksrskGdknlkel.viPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellr...dkssqkkiewd.

lFETACNRLASEAIRRGSSDNITVI
 |.   .. . ||..||| ||||..
.fneisrviveeavkrgsgDnitlv
subfamily_PPM1D_pd Subfamily PPM1D 254-353 1.8e-08 26.9 In-house 201-303 (309) alignment 
Range on Protein: 254-353
Range on HMM: 201-303/309.0
LEVSRSIGD-----GRFKRSGVICTPDIKKCQLGD-NDRYILLSCDGLWEGFEADAVMQFTNDILDGEKVKQSEGKSKDDVLFETACNRLASEAIRrgsS
| |.||.||      . ..  |   ||.|. .|   ....|.|. ||||.  ........ ..    ...|.....|   .| ..| .| .|. .|   .
LavaRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklr...a

DNITVI
||..||
Dnvsvi
subfamily_PDP_pd Subfamily PDP 271-338 6.9e-09 28.3 In-house 271-338 (398) alignment 
Range on Protein: 271-338
Range on HMM: 271-338/398.0
ICTPDIKKCQLGDNDRYILLSCDGLWEGFEADAVMQFTNDILDGEKVKQSEGKSKDDVLFETACNRLA
. .|.. . .|. ||....|. ||||. .. ..|..  .. |...| |.. . .. .. ...  ..|.
taePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkkekepvkveeakltlkqvveelk