Gene PP2D1 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PP2D1
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP183_AA protein Get Run
SpurP183_AA_411-538 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0034914 PP2C-like 158-775 5.3e-46 149.8 In-house 20-292 (295) alignment 
Range on Protein: 158-775
Range on HMM: 20-292/295.0
VRAVGICSDDNSrwKSKMEDTRVFQDYYGN-DVNKCFFGIYDGYNGRFAADIAANDLHHVFLSELQKVDERVSCTcavnladnndltdyelergspivrs
.  ||..|| .   ....||  ..   . . . . ..||..||..|  ||..|.. |.. .|..|.|..   . .                         
llrvgvasdqGr..rksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltls.........................

dsirhilheesiniiqqimhtcesnlmkmsdivsqesvgdwptrkkknrdpeFEKVSQAYHMSYLYLDRYLSYGINETSLVRWSGCSALSLLINSKeqle
                                                    .| . .|.. ..| .|..|   . . . ...||..|. .|| ..    
....................................................ledieealrkaflaadeellelallrpelagsGtTavvalirgn....

aenpgnkdentqtddgakdekkdreteatekeekgdseegqekesngsevhleelgVLHIANAGNTQAVLCRAGKAYHLTRDHTPGNPQERTRVEKAGSS
                                                         |..||.|...|||.| |....||.||.| |. || |...||  
........................................................klyvanvGDSravllrngelvqltvdhkpvnelererilsagga

VHAggpnGRVNGILDTTRGLGNYGDP------HLKKAVIPEPYTTSVKID-QHAQFIVMASCGLWDVLTDDDVLSLVKQTLAIHQSrtqaenvpdeyegy
|.     |||||.|  || || .         .|. .|..||..|..... .. .|...|| ||||||........|...|| ...              
vsh....grvngvlavtRalGdfdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgld..............

srsdvttygedylgesfatglsasyeqtgfdntvtsvididaaegdeanlqkkhflnplpslkedaddeddgddeanskseitwnepltdkgaedhqeap
                                                                                                    
....................................................................................................

snegksqnngirvegvaedvkaeieeetvpdmknykeefndnastktdfesmlsalcddgneadietltelhtfyaksrlseglgivdkkeeyrlaAEMI
                                                                                                .|..
................................................................................................leea

SERLVQSALMAGSRDNITAMVILLHG
.|.||. || .|||||||..|. |.|
aeeLvdlAlargsrDNiTvvvvrlng
subfamily_PPM1H_pd Subfamily PPM1H 158-293 4.9e-08 25.1 In-house 33-155 (404) alignment 
Range on Protein: 158-293
Range on HMM: 33-155/404.0
VRAVGICSDDNSRWKSKMEdtrvFQDYYGNDVNKCFFGIYDGYNGRFAADIAANDLHHVFLSELQKVDERVSCTCAvnladnndL---TDY--Elergsp
.. . ..............     ..   . ..  .||..||. |  || .|.. ||..  ..|..| | . .. |            .    .      
akvlllkkekkeksvtskp....kekseeeklplayfglfDGhaGsgaalvaskllhkhlkekledvlellleksa........eeeenteess......

IVRSDSIRHILHEESINIIQQIMHTCESNLMKMSDIVSQES
   . | ..| .|..|.  . ..   ||  ..| . ...| 
kespssvseiyeekeiskeeLviGalesaflemDeqiarer
subfamily_PP2D1_pd Subfamily PP2D1 159-776 8.1e-261 858.8 In-house 1-492 (492) alignment 
Range on Protein: 159-776
Range on HMM: 1-492/492.0
RAVGICSDDNSRWKSKMEDTRVFQDYYGNDVNKCFFGIYDGYNGRFAADIAANDLHHVFLSELQKVDERVSCTCAVNLADNNDLTDYELERGSpivRSDS
.|||||.|.||||||||||.|..|||.|||||.|||||||||||..||.|||..||.|.|.||.|||||||.|.||||.||||||||||||.|   ||||
kavGiCedknsrWKskmeDkrtlqdyfgndvnscFfgiyDGynGataAeiaakelhevlleelekvdervslttavnlidnndltdyeleras...rsds

IRHILHEESINiiqqimhtcesnlmkmsdivsqesvgdwptrkkknrdPEFEKVSQAYHMSYLYLDRYLSYGINETSLVRWSGCSALSLLINskeqleae
||.||.|||..                                     ||||||..|...|||.|||.|||||.|.|.|||||||||.||..        
irailkeesvk.....................................pefekvkkAfrksylrldrlLsygieeesrvrWsGCsAltllle........

npGNKdentqtddgakdekkdRETEATEKEEKGDSEEGQEKESNGSEVHLEELGVLHIANAGNTQAVLCRAGKAYHLTRDHTPGNPQERTRVEKAGSSVH
  |||                |||||||||||.|||||.|||||||||||||||||.||||||.||||||.|||..|||.|||.|..||||||||||.|.
..Gnk................reteatekeekkdseeGlekesngsevhleelgvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvv

AGGPNGRVNGILDTTRGLGNYGDPHLKKAVIPEPYTTSVKIDQHAQFIVMASCGLWDVLTDDDVLSLVKQTLAIHQSRTQAENVPDeyegysrSDVTTYG
....||.|||||||||||||||||.|||.|||||.|||||.|..|||.|.||.|||.||....|||||||||||..||..||||||       |||||.|
kseknglvnGildttRGLGnyGdpkLkksvipePkttsvkldeaaqflvlAsnGlWevlseeevlsLvkqtlaiyksrvraenvpd.......sdvttvg

EDYLGESFATGLSASYEQTGFDNTVTSVIDIDAAEGDEANLQKKHFLNPLPSLKEDADDEDDGDDEANSKSEITWNEPLTDKGAEDHQEAPSNEGKSQNN
||||||..|..|||.||.||||..|||.||.|||||||.||||....|.|...|||||||..|..|||||.|||.||..|||.||...||.|.|.||.|.
edylgEleakklsaryentgfdkfvtseidldaaegdesnlqklfsynelsevkedaddereglseanskkeityneedtdksaeeskeaksseekstnr

GIRVEGVAEDVKAEIEEETVPDmknykeefndnastktdfesmlsalcddgneadietltelhtfyaksrlseglGIVDKKEEYRLAAEMISERLVQSAL
.||||.|||.||||.||||..|                                                     |||||||.|.||||..|||||||||
sirveevaenvkaekeeetksd.....................................................givdkkekyelaAealserlvqsAL

MAGSRDNITAMVILLHGC
.||||||||.|||||.||
lAGsrDnitvmvilLkGc
PP2Cc_SM00332 166-533 4.9e-45 147.0 In-house 15-243 (274) alignment 
Range on Protein: 166-533
Range on HMM: 15-243/274.0
DDNSRWKSKMEDTRVFQDYYGNDVNKCFFGIYDGYNGRFAADIAANDLHHVFLSELQKVDERVsctcavnladnndltdyelergspivrsdsirhilHE
...  |...|||  | .  . .  .  |||..|| .|  .|..... |.. . .||.|...                                     ..
ssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdel...................................ed

ESINIIQQIMHTCESNLMKMSDIVSQESvgdwptrkkknrdpefekvsqayhmsylyldrylsyginetslvRWSGCSALSLLINSKEqleaenpgnkde
.  ..... .  ........ .   .|                                               ||..|.. |.. .             
dveealkkaflstdeeileeeqskelen............................................alsGstavvallkked............

ntqtddgakdekkdreteatekeekgdseegqekesngsevhleelgvLHIANAGNTQAVLCRAGKAYHLTRDHTPGNPQERTRVEKAGSSVHAGgpngR
                                                |..||.|  .|||||.|||  |..||.| ...|| |..||| .|. |    |
................................................lyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekg....r

VNGILDTTRGLGNYG----DPHLKKAVIPEPYTTSVKIDQHAQFIVMASCGLWDVLTDDDVLSLVKQTLAIH
||| |  .| .| .     ... .. ...|| .. |..... .|...|| ||||||....| ..|...||  
vngglavsrafGdhflkknkklkepyitaepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakg
subfamily_PPM1A_pd Subfamily PPM1A 166-537 2.6e-41 134.8 In-house 17-254 (282) alignment 
Range on Protein: 166-537
Range on HMM: 17-254/282.0
DDNSRWKSKMEDTRVFQDYYGNDVNKCFFGIYDGYNGRFAADIAANDLHHVFLSelqkvdervsctcavnladnndltdyelergspivrsdsirhilhe
. .. |...|||. . .   |.  .. || ..||  |. .|..... |..  |.                                              
ssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenile..............................................

esiniiqqimhtcesnlmkmsdivsQ----EsvgdwptrkKKNRDPEFEKVSQAYHMSYLYLDRYLSYGINETSLVRWSGCSALSLLINskeqleaenpg
                         .    |         .. .. | ..|..| . ..| ||  ..   ....    ||. |...|..           
.........................eeelke.........aaleasekdevkealrqgfLaldeairelstdlktadksGsTavtvlvs...........

nkdentqtddgakdekkdreteatekeekgdseegqekesngsevhleeLGVLHIANAGNTQAVLCRAGKAYHLTRDHTPGNPQERTRVEKAGSSVHagg
                                                    | |||.| . ||||| |||  ||.|| | .|.|..|.|.|| ||    
.................................................ekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvv...

pNGRVNGILDTTRGLGNYGDPH------LKKAVIPEPYTTSVKIDQHAQFIVMASCGLWDVLTDDDVLSLVKQTLAIHQSRT
 ..|||| |  .| || |   .       .. |..||..||...... .|.|.|. |.||||.|..|..||...| ...  .
.vsRvnGaLAvsRalGDyeykeeeekkaeeqlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadele
0049733 PP2C-like 170-538 2.2e-28 92.3 In-house 13-209 (235) alignment 
Range on Protein: 170-538
Range on HMM: 13-209/235.0
RWKSKMEDTRVFqdyygndvNKCFFGIYDGYNGRFAADIAANDLHHVFLSELQKvdeR---Vsctcavnladnndltdyelergspivrsdsirhilhee
|... .||. ..        .  .|...|| .|  |...|.. |....|..|..                                              
rvrkvneDavlv........glllfavaDGhgghaagevasellvetllellle...lllld......................................

siniiqqimhtcesnlmkmsdivsqesvgdwptrkkknrdpefekVSQAYHMSYLYLDRYLSYGINETSLVRWSGCSALSLLINSKEqleaenpgnkden
                                             . .| . ..|.....|     .   ....|..|. .|. ..              
.............................................leealrkaflaaneallelalaspelagmgtTavvalldggk.............

tqtddgakdekkdreteatekeekgdseegqekesngsevhleelgvLHIANAGNTQAVLCRAGKAYHLTRDHTPGNPQERTRVEKAGSSVhaggpngRV
                                               |..||.|.. |.|.| ||...||.||.| |..|| |...||  |       ||
...............................................lyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav.......rv

NGILDTTRGLGnygDPHLKkavipePYTTSVKIDQHAqFIVMASCGLWDVLTDDDVLSLVKQtlaiHQSRTQ
.|.|  || ||   |..||      |..|.......  |...|| ||||||.|.....|...    .  .  
pgrlaltralG...dlllk......pdvtvlelepgd.flllasDGlwdvlsdeeivdllrs....ldleea
subfamily_PPM1L_pd Subfamily PPM1L 172-235 2.6e-07 23.2 In-house 16-79 (269) alignment 
Range on Protein: 172-235
Range on HMM: 16-79/269.0
KSKMEDTRVFQDYYGNDVNKCFFGIYDGYNGRFAADIAANDLHHVFLSELQKVDERVSCTCAVN
. .|||   ...   |.... ||...||. | |||. | . | .  ...|...|.    |  .|
rprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepin
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 172-222 6e-07 22.0 In-house 17-67 (255) alignment 
Range on Protein: 172-222
Range on HMM: 17-67/255.0
KSKMEDTRVFQDYYGNDVNKCFFGIYDGYNGRFAADIAANDLHHVFLSELQ
.. |||  |    . .. .. .. ..||. || ||..|...|.... . |.
rptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelykilaelld
subfamily_PPM1E_pd Subfamily PPM1E 173-228 6.9e-06 18.4 In-house 16-77 (265) alignment 
Range on Protein: 173-228
Range on HMM: 16-77/265.0
SKMEDTRV----FQDYYG--NDVNKCFFGIYDGYNGRFAADIAANDLHHVFLSELQKVDERV
 ||||  |    .  ...  .. .. ||...||. |  ||. ||. ||..  .. .  .. .
rkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa
subfamily_PPM1G_pd Subfamily PPM1G 357-534 1.2e-24 80.2 In-house 249-433 (473) alignment 
Range on Protein: 357-534
Range on HMM: 249-433/473.0
AENPGNKDENTQTDDGAKDEKKDRETEATEKEEKGDSEEGQEKESN----GSEVHLEELGVLHIANAGNTQAVLCRAGKAYHLTRDHTPGNPQERTRVEK
 |.  ...|. .  | ...|......| .|..|. |..|..|.. .       | | .   | .||||.. .||.|.|||  |  || | ...|..|.||
eedeeeaeeeeeeedeedeeeeeedgegeeakeeldgseekeepGedsGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiek

AGSSVHAggpNGRVNGILDTTRGLGNYGD------PHLKKAVIPEPYTTSVKIDQHAQFIVMASCGLWDVLTDDDVLSLVKQTLAIHQ
||  |.    .||||| |.  | ||..        |.  . .   |     .. .. .|.|.|. |.|.|.. ..|.  |.. |. ..
AGGkvde...dgRvnGGLnlsRAlGDhaYkkneeLplkeqmisAlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkge
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 402-531 2e-17 56.0 In-house 116-243 (276) alignment 
Range on Protein: 402-531
Range on HMM: 116-243/276.0
NGSEVHLEELGVLHIANAGNTQAVLCRAGKAYHLTRDHTPGNPQERTRVEKAGSSVHAGgpNGRVNGILdTTRGLGNYGDPHLKKAVIPEPYTT-SVKID
.| | . ..   | .|| |.. | |.|  .. .|. ||   .|.|. |. . | ..  .  . |.||..  .| ||..   .|   .| ||| .  . . 
dGeeqqqqqqrylqvanvGdssaflsrGneslelskdhkatdpeekqrikddGitlsdn..qtrinGla.vsralGdhfikelniGlisepyvsnrillt

QHAQFIVMASCGLWDVLTDDDVLSLVKQTLA
 . .|...|| |||||.. .| .  ||    
pfdkflivasdGlwdvisGkdaiekvkslyd
subfamily_PPM1G2_pd Subfamily PPM1G2 408-533 1e-20 66.8 In-house 124-250 (287) alignment 
Range on Protein: 408-533
Range on HMM: 124-250/287.0
LEELGvLHIANAGNTQAVLCRAGKAYHLTRDHTPGNPQERTRVEKAGSSVHAggpnGRVNGILDTTRGLGNYGDPH------LKKAVIPEPYTTSVKIDQ
..|   | .||||. .|||. .|..  |..|| | . .|..|...||  |.     .|||| |   | ||..   .        . |  .|  .  |.|.
ikeek.lyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfvel....nrvngnLalsralgDfefkknvkkkpeeqivtavPDvlvkklde

HAQFIVMASCGLWDVLTDDDVLSLVKQTLAIH
.  |.|.|  |.|||||...|. ||.. |. .
ddeflvLaCDGiWDvltnkevvdlvrerlvsg
subfamily_PDP_pd Subfamily PDP 408-539 3.1e-11 36.0 In-house 161-321 (398) alignment 
Range on Protein: 408-539
Range on HMM: 161-321/398.0
LEELGvLHIANAGNTQAVLCRAG-----KAYHLTRDHTPGNPQERTRVEKAGSSVHA--GGPNGRVNGILDTTRGLGNYG---DP-----HLKK----AV
.|.   ||.||.| ..|||..       .| .|..|.|  |..| .|..|.  .  .     |||. | |  .|  |..    .      .|.|    ..
iegte.lhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirngRlLgeLqPlRAFGdvryKwseelqkkvlekaylkvl

IP-----------EPYTTSVKIDQHAQFIVMASCGLWDVLTDDDVLSLVKQTLAIHQSRTQA
 |           ||  || |. .. .|.|.|. ||||.|....| |||.. || ...... 
epkdyktPPYltaePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkkekepv
subfamily_PPM1H_pd Subfamily PPM1H 411-451 3.1e-06 19.2 In-house 173-211 (404) alignment 
Range on Protein: 411-451
Range on HMM: 173-211/404.0
LGVLHIANAGNTQAVLCRAGKAYHLTRDHTPGNpqERTRVE
|| |..||||...|.|.| ..   | .|.||    || |. 
lgklYvanaGDsRailvrkdeiiplsadftPet..eRqRlq
PP2C Protein phosphatase 2C 412-538 3.8e-38 124.5 Pfam-A 113-237 (255) alignment 
Range on Protein: 412-538
Range on HMM: 113-237/255.0
GvLHIANAGNTQAVLCRAGKAY-HLTRDHTPGNPQERTRVEKAGSSVHAggpNGRVNGILDTTRGLGNYgdpHLKK----AVIPEPYTTSVKIDQHAQFI
  |..||.| ..|||||...|.  ||.||.| ...|| |.|.|| ||.    |||||| |. .| || .   .||.    .|..||..||||.... .|.
k.lyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn...ngrvngsLavsRalGdf...elkpkeeqlvsaePdvtsvklteedefl

VMASCGLWDVLTDDDVLSLVKQTLAIHQSRTQ
..|| ||||||.|... .||...|  ..| ..
iLasdGlwdvlsdqeavdlvrselskkkspme
PP2C Protein phosphatase 2C 412-538 3.8e-38 124.5 In-house 113-237 (255) alignment 
Range on Protein: 412-538
Range on HMM: 113-237/255.0
GvLHIANAGNTQAVLCRAGKAY-HLTRDHTPGNPQERTRVEKAGSSVHAggpNGRVNGILDTTRGLGNYgdpHLKK----AVIPEPYTTSVKIDQHAQFI
  |..||.| ..|||||...|.  ||.||.| ...|| |.|.|| ||.    |||||| |. .| || .   .||.    .|..||..||||.... .|.
k.lyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn...ngrvngsLavsRalGdf...elkpkeeqlvsaePdvtsvklteedefl

VMASCGLWDVLTDDDVLSLVKQTLAIHQSRTQ
..|| ||||||.|... .||...|  ..| ..
iLasdGlwdvlsdqeavdlvrselskkkspme
subfamily_PPM1K_pd Subfamily PPM1K 412-530 7.6e-22 70.7 In-house 111-229 (263) alignment 
Range on Protein: 412-530
Range on HMM: 111-229/263.0
GVLHIANAGNTQAVLCRAGKAYHLTRDHTPGNPQERTRVEKAGSSVHAGG-PNGRVNGILDTTRGLGnygDPHLKK-AVIPEPYTTSVKIDQ-HAQFIVM
  | .|. |...|.||| ||| .|||||.|   .|. |. .|| ||.     . .||| |  || ||   |  ||.  || .| | |.|.|  .  |.|.
telvlaslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslG...dldlkryGviatPetkslkvdhaadsflvl

ASCGLWDVLTDDDVLSLVKQTL
 . |. .|... ..  ||..  
itdgisfvvnsqelcdlvrlch
PPM_PTC7_SpoIIE 412-533 3.1e-13 43.1 In-house 105-212 (230) alignment 
Range on Protein: 412-533
Range on HMM: 105-212/230.0
GVLHIANAGNTQAVLCRA-GKayhltrdhtpgnpqERTRVeKAGSSVHAGGPNGRVNGILDTTRGLGNYGDPHLKKAVIPEPYtTSVKID-QHAQFIVMA
| |..||||.  ..|.|. |.              ||.|. .||  .. |  .|||.| |  ..  | .   .  . | .||. || ... .. .|...|
gklyvanaGdsppllvrddgg..............ereri.vagglpslGilpgrvfgvlavslapGdllllytDGvveaepd.tsdgelfgkdeflila

SCGLWDVLTDDDVLSLVKQTLAIH
| ||||||.......||...|  .
sdglwdvlspqelvdlvrdelekp
subfamily_PPM1E_pd Subfamily PPM1E 413-534 2.5e-26 85.5 In-house 115-232 (265) alignment 
Range on Protein: 413-534
Range on HMM: 115-232/265.0
VLHIANAGNTQAVLCRAGKAYHLTRDHTPGNPQERTRVEKAGSSVHAGGpNGRVNGILDTTRGLgnyGDPHLKKAVIPEPYTTSVKIDQHAQFIVMASCG
 |..|  |. ||.|.| |.| .|.. | | ...|. |.|.||  |   | . ||||.|  .| .   ||..||. |. |. ...|..|.. .....|. |
qlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvig.awRvnGvLsvsRai...GDvklkpyvsgeadvaeveldgseeylilacDG

LWDVLTDDDVLSLVKQTLAIHQ
||||.....|..||.. || ..
lwDvvneeevvklveefladga
subfamily_ILKAP_pd Subfamily ILKAP 413-542 4e-22 71.7 In-house 126-255 (293) alignment 
Range on Protein: 413-542
Range on HMM: 126-255/293.0
VLHIANAGNTQAVLCRAGKAYH------LTRDHTPGNPQERTRVEKAGSSVHaggpNGRVNGILDTTRGLGnygDPHL-KKAVIPEPYTTSVKIDQHAQF
||..|| |...|||.|  .. .      ||.|||| . .|| |..|||..|.    .|||.|.|. .| .|   | .  .  ||  | .. .....  .|
vlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvr....dgrvlGvlevsrsiG...dgrfkrlGvistPdvkkceLtendlf

IVMASCGLWDVLTDDDVLSLVKQTLAIHQSRTQAENV
.|.|  |||.|.. |.|.. . ..|  ... .. .. 
vvlaCdGLwkvfsadevvkfilkvledeeddrkikee
subfamily_PHLPP_pd Subfamily PHLPP 413-528 1.3e-13 43.4 In-house 106-214 (246) alignment 
Range on Protein: 413-528
Range on HMM: 106-214/246.0
VLHIANAGNTQAVLCRAGKAYHLTRDHTPGNPqERTRVEKAGSSVHAggpNGRVNGILDTTRGLGNYgdpHLKKAVIPEPYTTSVKIDQHAQFIVMASCG
.|..|. |. ||||.| ||   |.. ..  .  |  |. .| . .     ....||.. .|| || .   .|   |.|.|   .|.. .   .... .  
sLevAsvGtlqavliRngkklrlsksyviekd.elkrikeakaiite...dnkingviestrllGyt...flfPvvlPkphvrevlLteqdellivGnka

LWDVLTDDDVLSLVKQ
||.||  |.. . |..
lWevlsideaveavrk
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 413-492 4.6e-08 25.9 In-house 99-194 (292) alignment 
Range on Protein: 413-492
Range on HMM: 99-194/292.0
VLHIANAGNTQAVLCR--AGKAY---HLTRDHTPGNPQERTRVEKAGSSVHA-----GGP--NGRV------NGILDTTRGLGNYgdpHLKKA-VIPEP
 | .|| |...|.| |  .|  |    |.||| | .|.|| |. .||  |.       |     ||      .| |  .| ||..   ||..| |. ||
alilanvGdsrallgrclggsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdf...hlfeaGvvaeP
PPM_PTC7 414-533 2.3e-35 115.3 In-house 115-237 (259) alignment 
Range on Protein: 414-533
Range on HMM: 115-237/259.0
LHIANAGNTQAVLCRAGKAY-HLTRDHTPGNPQERTRVEKAGSSVHAGgPNGRVNGILDTTRGLGNYgdpHLK------KAVIPEPYTTSVKIDQHAQFI
|..||.|...||||| |.|.  ||.||.| |..|| |.|.|| ||.    |||||| |. .| .| .   .||      ..|..||...|.||| . .|.
lyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnv.gngrvngvlavsRafGdf...elkpketeeqlvsaePdisstkideedefl

VMASCGLWDVLTDDDVLSLVKQTLAIH
..|| |||||..|... .||...|. .
iLasdGlwdvvsdqeavdlvrselskk
subfamily_PPM1L_pd Subfamily PPM1L 414-530 3.2e-20 65.5 In-house 120-236 (269) alignment 
Range on Protein: 414-530
Range on HMM: 120-236/269.0
LHIANAGNTQAVLC-RAGKAYHLTRDHTPGNPQERTRVEKAGSSVHAGGpNGRVNGILDTTRGLGNYGDPHlKKAVIPEPYTTSVKIDQH-AQFIVMASC
| .|| |... ||. . |||  |. || | ...|| |..|||  .   |   ||.|.| |.| ||.|   . |. ||..|   . ..|.|  .|...|| 
livanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrG.vwrvaGvlatsralGdyplkd.knlviadpdiltfdlddhkpeflilasd

GLWDVLTDDDVLSLVKQTL
|||| ..... .  .|. |
Glwdtfsneeavrfikerl
subfamily_KAPP-like_pd Subfamily KAPP-like 414-531 1.4e-16 53.3 In-house 118-233 (266) alignment 
Range on Protein: 414-531
Range on HMM: 118-233/266.0
LHIANAGNTQAVLCRAGKAYHLTRDHTPGNPQERTRVEKAGSSVHAGgpNGRVNGILdTTRGLGNYGDPHLKKAVIPEPYTT-SVKIDQHAQFIVMASCG
| .|| |.. | |.|  .. .|. ||   .|.|. |. . | ..  .  . |.||..  .| ||..   .|   .| ||| .  . .  . .|...|| |
lqvanvGdssaflsrGneslelskdhkakdpeekqrikddGitlsdn..qtrinGla.vsralGdhfikelniGlisepyvsnrilltpfdkflivasdG

LWDVLTDDDVLSLVKQTLA
||||.. .| .  ||    
lwdvisGkdaiekvkslyd
subfamily_TAB1_pd Subfamily TAB1 414-517 8.1e-07 21.1 In-house 143-260 (333) alignment 
Range on Protein: 414-517
Range on HMM: 143-260/333.0
LHIANAGNTQAVLCR---AGKAYHLTRDHTPGNPQERTRVEKAGSSVHAGGPNGRVnGILDTTRGLGNYGDPHL-------KK----AVIPEPYTTSV-K
|..||.|. .|.|..     |   |  |||  |..| .|... |  ..    |.|. |  ..|| .|.|   ..       ..     || ||  .   .
LyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrl.gskentRsiGdykvkkgykdvdilssakgePviaePdiqgayp

IDQHAQFIVMASCGLWDVL
||.  .|.|. | |.   |
iddityflvlmSdGvyktL
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 415-528 1.2e-23 76.7 In-house 110-222 (255) alignment 
Range on Protein: 415-528
Range on HMM: 110-222/255.0
HIANAGNTQAVLC-RAGKAYHLTRDHTPGNPQERTRVEKAGSSVHAGGPNGRVNGILDTTRGLGnygDPHLKKAVIPEPYTT-SVKIDQHAQFIVMASCG
 ||| |....||| . | |  |. || | ...|. |....|  | ..    |||| |  .| ||   | .|.  |.|.|. . |..| .. .|...|  |
yianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralG...dsflePfvvpdPdlsqsleiskkdkflilacdG

LWDVLTDDDVLSLVKQ
.||...|..  ..| .
iwdlisdeeaveivag
Subfamily Dicty-PPM1L-like 445-545 2e-08 26.4 In-house 181-278 (305) alignment 
Range on Protein: 445-545
Range on HMM: 181-278/305.0
QERTRVEKAGSSVHAGGpNGRVNGILDTTRglgNYGDPHLKKAVIPEPYTTSVKIDQH-AQFIVMASCGLWDVLTDDDVLSLVKQTLAIHQSRTQAENVP
..| |.| .....   | . .||..|   |   . ||  ||. |||..      . .   ||.|.|  |||.||  .||   ||. | ...|  . |  .
eiririeslqaalynyg.ellvnrllkksr...skGdknlkelviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdf

DE
.|
ne
subfamily_PPM1H_pd Subfamily PPM1H 462-536 9.1e-07 20.9 In-house 273-357 (404) alignment 
Range on Protein: 462-536
Range on HMM: 273-357/404.0
PNGRVNGILDTTRGLGNYG------DPHLKKAVIPEPYTTSVKIDQH----AQFIVMASCGLWDVLTDDDVLSLVKQTLAIHQSR
   |. . . .|||||..       . ..|  . |.|  . . ..|      . ...|. ||||||....|. .|...|.  ...
kkaRllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskvepe
subfamily_PPM1D_pd Subfamily PPM1D 487-537 7.4e-09 28.1 In-house 221-272 (309) alignment 
Range on Protein: 487-537
Range on HMM: 221-272/309.0
AVIPEPYTTSVKIDQHAQ-FIVMASCGLWDVLTDDDVLSLVKQTLAIHQSRT
 | |||... ...|.. . ||..|| |||.||| .|. |.|... ....   
vvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelke
PPM_PTC7_motif 507-531 1.7e-06 21.5 In-house 1-25 (51) alignment 
Range on Protein: 507-531
Range on HMM: 1-25/51.0
VMASCGLWDVLTDDDVLSLVKQTLA
..|| ||||||.|... .||...|.
iLAsDGLWDvlsdqeavdlvrdqls