Gene PPM1A in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1A
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP184_AA protein Get Run
SpurP184_AA_3-300 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0034914 PP2C-like 4-300 2.5e-86 281.9 In-house 3-293 (295) alignment 
Range on Protein: 4-300
Range on HMM: 3-293/295.0
FLEKPNTEKENERGSGNGLRYGLSSMQGWRVEMEDAHSAVTGLPHGLKDWSFFAVFDGHAGSKVAKHCSEHILHEITSNPEFLgspkvDGKLNPSTDAVK
.|..|..|. . . . . ||.| .|.||.| ..|||...|..|...|.|...|.||||| |...|...||...... .. | |     .  | .|.. ..
llslpllellllsslllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekl.....lllltlsledie

EGIRTGFLSIDSKMRTDFARTDSSDKSGSTAVGVIISPKHLFFANCGDSRSVLSRKGedKPTFSTEDHKPGKPKEMKRIEDAGGSVMIERVNGSLAVSRA
| .|..||..| .... . .  . . ||.||| ..| ...|..||.|||| ||.|.|  .... |.||||  . |..||..||| |. .||||.|||.||
ealrkaflaadeellelallrpelagsGtTavvalirgnklyvanvGDSravllrng..elvqltvdhkpvnelererilsaggavshgrvngvlavtRa

LGDYDYKNNPDKPPTEQLVSPEPEVTVFERT-DEEEFIILACDGIWDVMSNEELCQFIRSRLAITDNLEEICNQVIETCLQKGSRDNMSIVIVLFQNA
|||.|.|...  ...|.|||.||.|||.|.| .. .|..||.||.|||.||||.....||.|| ...|||....... .|..|||||...|.| ... 
lGdfdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTvvvvrlngl
subfamily_PPM1G_pd Subfamily PPM1G 4-119 8.7e-25 80.6 In-house 1-101 (473) alignment 
Range on Protein: 4-119
Range on HMM: 1-101/473.0
FLEKPNTEKENERGSGNGLRYGLSSMQGWRVEMEDAHSAVTGLPhglKDWSFFAVFDGHAGSKVAKHCSEHILHEITSNPEFlgspkvdgklnpSTDAVK
.|.||..|||.| .| ..|.|| |.||||||..|||| ..| |    .|.|.|||.||| |..|||........ .. .  .              . |.
ylskpkvekesedesneelsygasamqGwrvsqEDahncitdld...edtslfavyDGHGGkevakyvakklpdllkaqkgy............kegdve

EGIRTGFLSIDSKMRT
....  ||..|.|...
kaleeaflalDeklka
subfamily_PPM1G2_pd Subfamily PPM1G2 5-297 2e-89 292.3 In-house 2-286 (287) alignment 
Range on Protein: 5-297
Range on HMM: 2-286/287.0
LEKPNTEKENERGSGNGLRYGLSSMQGWRVEMEDAHSAVTGLPH--GLKDWSFFAVFDGHAGSKVAKHCSEHILHEITSnpeflgspkvdgKLNPSTDAV
|..| ..||.. .. .  . | |.|||.|..|||||   . | .    |. ..||||||| |.||||...... . |..            | . . .|.
lsepvvakesascanaltkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiak............kksfkegal

KEGIRTGFLSIDSKMRTDFARTDssDKSGSTAVGVIISPKHLFFANCGDSRSVLSRKGEdKPTFsTEDHKPGKPKEMKRIEDAGGSVMIERVNGSLAVSR
.. .. .||..|.... | .  |  ...||||| |.|. ..|. ||.||||.||| ||.   .. . |||| . .| |||..||| | ..||||.||.||
eqilkdafletDeellkdeklkd..esaGstavvvlikeeklyvanaGDsravlsskgn.vkal.sfDhkPqeesekkriiaagGfvelnrvngnLalsr

ALGDYDYKNNPDKPPTEQLVSPEPEVTVFERTDEEEFIILACDGIWDVMSNEELCQFIRSRLAITDNLEEICNQVIETCLQKGSR------DNMSIVIVL
||||. .|.|  |.| ||.|  .|.|.| ......||..|||||||||..|.|.....|.||.   .|.||.......||.. |.      |||..||| 
algDfefkknvkkkpeeqivtavPDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvvivv

F
.
l
subfamily_PPM1A_pd Subfamily PPM1A 12-299 7.1e-128 418.8 In-house 2-282 (282) alignment 
Range on Protein: 12-299
Range on HMM: 2-282/282.0
KENERGSGNGLRYGLSSMQGWRVEMEDAHSAVTGLPhGLKDWSFFAVFDGHAGSKVAKHCSEHILHEITSNPEFLGspkvDGKLNPSTDAVKEGIRTGFL
| .....|||||||.||||||||||||||..|. |. .||||||||||||||||.|||....|.|..|... |.        . . ..|.|||..|.|||
kpksqaegnglrygvssmqgwrvemEDahtvvaslg.alkdwsfFavfDGHaGsevakyvkkhllenileeeelke....aaleasekdevkealrqgfL

SIDSKMRTDFARTDSSDKSGSTAVGVIISPKHLFFANCGDSRSVLSRKGedKPTFSTEDHKPGKPKEMKRIEDAGGSVMIERVNGSLAVSRALGDYDYKN
..|...|.........||||||||.|..|.|||..||.||||.||.|.|  | .|.|||||| .|||.||||.|||||...||||.||||||||||.||.
aldeairelstdlktadksGsTavtvlvsekhliianlGDsRavlcrng..kaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDyeyke

NPDKPPTEQLVSPEPEVTVFERTDEEEFIILACDGIWDVMSNEELCQFIRSRLAITDNLEEICNQVIETCLQKGSRDNMSIVIVLFQN
...|...|||||.|||||..||..|..|..|||||||||.|.||.....|.|| ..|.|||.........|.||||||.|...|||..
eeekkaeeqlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsrDNlsvlvvlfak
PP2Cc_SM00332 14-295 8.4e-85 277.5 In-house 2-274 (274) alignment 
Range on Protein: 14-295
Range on HMM: 2-274/274.0
NERGSGNGLRYGLSSMQGWRVEMEDAHSAVTGLPhGLKDWSFFAVFDGHAGSKVAKHCSEHILHEITSNPEFLGSPKvdgklnpsTDAVKEGIRTGFLSI
.| ||..||.||.|||||||..|||||  |. |    .||.||.|||||.||.||| .|... . . .....  . .         |.|.| ....|||.
sesgsnlglsygkssmqgwrksmeDahvvvvdlv.eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdel........eddveealkkaflst

DSKMRTDFARTDSS-DKSGSTAVGVIISPKHLFFANCGDSRSVLSRKGEdkPTFSTEDHKPGKPKEMKRIEDAGGSVMIERVNGSLAVSRALGDYDYKNN
|......  .      .|||||| .... ..|..||.|||| ||.|.|.   .  ..|||| ...|.|||..|||.|. .||||.||||||.||...|.|
deeileeeqskelenalsGstavvallkkedlyvanvGDSravlcrngk..avqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdhflkkn

PdkPPTEQLVSPEPEVTVFERTDEEEFIILACDGIWDVMSNEELCQFIRSRL--AITDNLEEICNQVIETCLQK-GSRDNMSIVIV
   ...|. ...||.|.| . |.|.||.|||.||.|||.||.|.....|..|    | . .|......| .... ||.||...|.|
k..klkepyitaepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv
0049733 PP2C-like 22-298 1.9e-59 193.7 In-house 3-234 (235) alignment 
Range on Protein: 22-298
Range on HMM: 3-234/235.0
LRYGLSSMQGW-RVEMEDAHSAvtglphglkDWSFFAVFDGHAGSKVAKHCSEHILHEITSNPEFlgspkvdgklnPSTDAVKEGIRTGFLSIDSKMRTD
|..| .|..|. | ..|||. .         ....|||.||| |. .....||.... . .  .            ...  ..| .|  || ... ..  
lsvgaasdigrvrkvneDavlv.........glllfavaDGhgghaagevasellvetllellle...........lllldleealrkaflaaneallel

FARTDSSDKSGSTAVGVIISPKHLFFANCGDSRSVLSRkgEDKPTFSTEDHKPGKPKEMKRIEDAGGSVmieRVNGSLAVSRALGDYDYKnnpdkppteq
  .  . . .|.||| ... ...|..||.|||| .| |  ..| .. ||||.|  . |..||..||| |   ||.|.||..|||||...|          
alaspelagmgtTavvalldggklyvanvGDsrayllr..dgklvqltedhspvnelerqriitaggav...rvpgrlaltralGdlllk..........

lvspePEVTVFERTDEEeFIILACDGIWDVMSNEELCQFIRSrlaitDNLEEICNQVIETCLQKGSRDNMSIVIVLFQ
     |.|||.| .... |..||.||.|||.|.||.....||     ..|||......|..|..|.|||...|.| ..
.....pdvtvlelepgd.flllasDGlwdvlsdeeivdllrs.....ldleeaaerlvelalarggrDNiTvvvvrld
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 22-297 1.5e-46 151.8 In-house 6-253 (255) alignment 
Range on Protein: 22-297
Range on HMM: 6-253/255.0
LRYGLSSMQGWRVEMEDAHSAVtGLPHGLKDWSFFAVFDGHAGSKVAKHCSEHIlHEITSnpEFLgspkvdgKLNPStdAVKEGIRTGFLSIDSKMrtdf
.. | | | | |  |||  ..  |  .. .|  ..|.||||.|.. ||..||.. . |    |.|       .||..  . .. ..  . .|. ..    
fkvgfsdmiGrrptmedelviy.GsfrdksdedyyalfdGhgGraaakfaseel.ykila..ell.......dlnna..nPvkslkkaykeistqi....

arTDSSDKSGSTAVGVIISPKHLFFANCGDSRSVLSRKGEDKPtFSTEDHKPGKPKEMKRIEDAGGSVMIE----RVNGSLAVSRALGDYdYKNnPdkpp
  .. .   |.||. |.|  .. . || |||| ||..|        . |||| ...| |||...|| |. .    |||| |||||||||  . . |    
..serpkfiGttaasvliiedkvyianvGdsrvvlcqkdgtak.rlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGds.fle.P....

teqLVSPEPEVT-VFERTDEEEFIILACDGIWDVMSNEELCQFIrsrLAITDnLEEICNQVIETCLQKGSRDNMSIVIVLF
    | |.|...  .| . ...|.|||||||||..|.|| .. .   ..|.|  |. .... .   ..|| ||.|.... .
...fvvpdPdlsqsleiskkdkflilacdGiwdlisdeeaveiv...agisd.pekaaeklrdlayssGstdnisvivikl
PP2C Protein phosphatase 2C 23-290 1.1e-87 286.8 Pfam-A 2-255 (255) alignment 
Range on Protein: 23-290
Range on HMM: 2-255/255.0
RYGLSSMQGWRVEMEDAHSAVTGLP--HGLKDWSFFAVFDGHAGSKVAKHCSEHILHEITSNPEFLGSPkvdgklnpstdAVKEGIRTGFLS-IDSKMRT
..| |..||.| .||||| |   |    | ....||||||||.|...|| ..||.   . ....||..             |....| .||. .|.....
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele...........kvekalrksfladtdeelks

DFARTdSSDKSGSTAVGVIISPKHLFFANCGDSRSVLSRKGEDKpTFSTEDHKPGKPKEMKRIEDAGGSVM-IERVNGSLAVSRALGDYDYKNNPdkppt
. |.| . .||||||| ..|..|.|..||.|||| ||.||...| .. |||||| ...|..|||.|||||. . ||||||||||||||...|...     
skant.epsksGstavvalirgkklyvAnvGDSravLcrkdnak.keltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....

EQLVSPEPEVTVFERTDEEEFIILACDGIWDVMSNEELCQFIRSRLAITDNLEEICNQVIETCLQKGSRDNM
|||||.||.||....|.|.||.|||.||.|||.|..|.....||.|  .....|....... ....||.||.
eqlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PP2C Protein phosphatase 2C 23-290 1.1e-87 286.8 In-house 2-255 (255) alignment 
Range on Protein: 23-290
Range on HMM: 2-255/255.0
RYGLSSMQGWRVEMEDAHSAVTGLP--HGLKDWSFFAVFDGHAGSKVAKHCSEHILHEITSNPEFLGSPkvdgklnpstdAVKEGIRTGFLS-IDSKMRT
..| |..||.| .||||| |   |    | ....||||||||.|...|| ..||.   . ....||..             |....| .||. .|.....
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele...........kvekalrksfladtdeelks

DFARTdSSDKSGSTAVGVIISPKHLFFANCGDSRSVLSRKGEDKpTFSTEDHKPGKPKEMKRIEDAGGSVM-IERVNGSLAVSRALGDYDYKNNPdkppt
. |.| . .||||||| ..|..|.|..||.|||| ||.||...| .. |||||| ...|..|||.|||||. . ||||||||||||||...|...     
skant.epsksGstavvalirgkklyvAnvGDSravLcrkdnak.keltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....

EQLVSPEPEVTVFERTDEEEFIILACDGIWDVMSNEELCQFIRSRLAITDNLEEICNQVIETCLQKGSRDNM
|||||.||.||....|.|.||.|||.||.|||.|..|.....||.|  .....|....... ....||.||.
eqlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PPM_PTC7 23-290 6.5e-87 284.2 In-house 2-259 (259) alignment 
Range on Protein: 23-290
Range on HMM: 2-259/259.0
RYGLSSMQGWRVEMEDAHSAVTGLP--HGLKDWSFFAVFDGHAGSKVAKHCSEHILHEITSNPEFLGSPkvdgklnpstdAVKEGIRTGFLS--IDSKMR
..| |..||.|..||||| |  .|    | ....||||||||.|...|| ..||.   . ....|  .             .....|..||.  .|....
dggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeele...........klekalrksflaldtdeelk

TDFARTdSSDKSGSTAVGVIISPKHLFFANCGDSRSVLSRKGEDKpTFSTEDHKPGKPKEMKRIEDAGGSVM---IERVNGSLAVSRALGDYDYKNNPDk
.. |.|  ...|||||| ..|....|..||.|||| ||.|.|... .. |||||| ...|..|||.|||||.     ||||.||||||.||...|...  
sseant.epstsGstAvvalitgsklyvAnvGDSravLcrsgnav.kqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpket.

ppTEQLVSPEPEVTVFERTDEEEFIILACDGIWDVMSNEELCQFIRSRLAITdNLEEICNQVIETCLQKGSRDNM
  .|||||.||.... ....|.||.|||.||.|||.|..|.....||.|. .  ..|............||.||.
..eeqlvsaePdisstkideedefliLasdGlwdvvsdqeavdlvrselskk.dpmeaaeklvdeaiargsedni
PPM_PTC7_SpoIIE 23-282 8.1e-47 152.9 In-house 2-222 (230) alignment 
Range on Protein: 23-282
Range on HMM: 2-222/230.0
RYGLSSMQGWRVEMEDAHSAVTGLP--HGLKDWSFFAVFDGHAGSKvaKHCSEHILHEITSNPeFLGSPkvdgklnpstdAVKEGIRTGFLSIDSKMRTD
..| |..||.| .||||| .  ..    |   . .....||| |.   . .....   . ..  | |..            ..| .| ..| .. .....
dggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrela.fagle...........kpeeilrrlnlalaadlede

fartdsSDKSGSTAVGVIISPKH--LFFANCGDSRSVLSRKgEDKptfstedhkpgkpkEMKRIeDAGGSVM----IERVNGSLAVSRALGDYDYKNnpd
       ..||.||| ..| | .  | .||.|||. .|.|. ...              | .|| .||| ..     .||.|.||||.| ||. ..    
......psssgaTavvalidpstgklyvanaGdsppllvrd.dgg..............ereri.vagglpslGilpgrvfgvlavslapGdlllly...

kppTEQLVSPEPEvTVFERTDE-EEFIILACDGIWDVMSNEELCQFIRSRLAITdnleeICNQVIETCL
   |...|..||. |. ..... .||.|||.||.|||.|..||....|..|        .... .| ..
...tDGvveaepd.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp.....aaeglleDDi
Subfamily Dicty-PPM1L-like 23-298 3.3e-20 65.1 In-house 8-304 (305) alignment 
Range on Protein: 23-298
Range on HMM: 8-304/305.0
RYGLSSMQGWRVEMEDAHSAVTGLPHGlKDWSFFAVFDGHAGSKVAKHCSEHIlHEITSnpEFLGSPKVD--GKLNPSTDAVKEGIRTGFLSIDSKmRTD
.|.|   .. |   || .    .|    .. |.| ||||| | . |..   ..  ||    ...   ||    | . . |   | |. ..|| |.    |
kyelyvsansrkyqedrnkvkisless.qelslfGvfdGhnGdiaaeyvkkkl.veivn..kyvkenkvGysaknlnvddlpleaiksaslstdks.sld

FARTDSSdKSGSTA----VGVIISPKHLFFANCGDSRSVLSRKGEDKPTFSTEDHK------PG-------------KPKEMKRIEDAGGSVMIE---RV
.| .|.  |.|.|       ||.  . .  .. .|. .|||  .  ..  . .  |      ||             . ..  ||| ......     .|
saesdnk.kaGttlngssasvilerertivstasdtevvlssGaiaeglsiinsPkgvgfdspgwmkfnhlynqnnfldeiririeslqaalynygellv

NGSLAVSRALGDYDyknnpdkppTEQLVSPEPEVTVFERT-DEEEFIILACDGIWDVMSNEELCQFIRSRLAITDNL-------EEICNQVIETCLQKGS
|. | .||  || .         ...|| |...  ..  .  ...|..|| ||.|.|.|.... ....  | ..          .|| . . |  ...||
nrllkksrskGdkn.........lkelviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneisrviveeavkrgs

RDNMSIVIVLFQ
.||. .||. ..
gDnitlviiklk
subfamily_PPM1K_pd Subfamily PPM1K 25-298 8.5e-35 113.1 In-house 7-259 (263) alignment 
Range on Protein: 25-298
Range on HMM: 7-259/263.0
GLSSMQGWRVEMEDAHSaVTGLPhglKDWSFFAVFDGHAGSKVAKHCSEHILHEITsnpeflgspkvdgKLNPSTDAVKEGIRTGFLSIDSKMRTDFART
|  |..| | | ||  . .. |    ..  ..|||||||||  |... ... . ..             .| .  . ... ..  |. .| |..     .
GkdsliGkraenedrik.lkeld...pellyvavfdGhaGsaaadfvhdklekilk.............rllekekdleivlknafeeldkklkrylefs

---DSSDKSGSTAVGV-IISPKHLFFANCGDSRSVLSRKGEDKptFSTEDHKPGKPKEMKRIEDAGGSVMI-----ERVNGSLAVSRALGDYDYKNNPdk
    .  .||.||  . .   ..|  |. ||||..| |.|. |    |.||.| . .| .||  |||||        .||| ||..|.||| | |.    
vaeaellssGttatvsllrdGtelvlaslGdsrailcrnGkak..kltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryG..

ppteqlVSPEPEVTVFER-TDEEEFIILACDGIWDVMSNEELCQFIRsrlaITDNLEEICNQVIETCLQKGSRDNMSIVIVLFQ
      |  .||   ..   ... |..|  ||| .|....|||...|    .  . ||  . . |. || || || ..|.| ..
......viatPetkslkvdhaadsflvlitdgisfvvnsqelcdlvr....lchdpeeaahalteqalqygsednatavvvplg
subfamily_PPM1E_pd Subfamily PPM1E 27-298 1.2e-55 181.6 In-house 9-263 (265) alignment 
Range on Protein: 27-298
Range on HMM: 9-263/265.0
SSMQGWRVEMEDAHSAVTGLPHG-----LKDWSFFAVFDGHAGSKVAKHCSEHILHEITSNPEFLGSPKvdgklnpstdavkEGIRTGFLSIDSKMRTDF
 .... |  ||| | |.  | .       |. .||||||||.|.. ||. ..|. . . .....  .|.             | .. .|  .|... .  
aavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa.............ealkeafkltDerflqka

ARtdSSDKSGSTAVGVIISPKHLFFANCGDSRSVLSRKGEDKptFSTEDHKPGKPKEMKRIEDAGGSVMI---ERVNGSLAVSRALGDYDYKnnpdkppt
.|   . ||||||| |.|. ..|. |  |||...| ||||      .. ||| ...| ||||.||| |.     ||||.|.||||.||...|        
er..eklksGstavvvliekdqlyvaWlGDsqallvrkgeav..qlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklk........

eQLVSPEPEVTVFERTDEEEFIILACDGIWDVMSNEELCQFIRSRLAITD-NLEEICNQVIETCLQKGSRDNMSIVIVLFQ
 . || |..|. .| ...||..||||||.|||. .||... ... || .  .|.|. ....|.  ..||.||...|.|...
.pyvsgeadvaeveldgseeylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvvfld
subfamily_PPM1D_pd Subfamily PPM1D 27-192 1.9e-31 102.3 In-house 7-174 (309) alignment 
Range on Protein: 27-192
Range on HMM: 7-174/309.0
SSMQGWRVEMEDAHSAVTGLPHGL--KDWSFFAVFDGHAGSKVAKHCSEHILHEITSNPEFlgspkvdgkLNPSTDAVKEGIRTGFLSIDSKMRT---DF
.. || |  |||  . |.   . .  ....|.|||||| | . ||. .||....|. . .|         |. . ..| | || .||.. ..|.    ..
eadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkf.........lssepedvleAireaflatheamkkkleeW

ARTDSSDK--SGSTAVGVIISPKHLFFANCGDSRSVLSRKGE----DKPTFSTEDHKPGKPKEMKRIEDAGGSVMIE
..| | .   .|.||  |||  ..|. |. |||. ||. | .     ...  |.|||| .|.| .|||..||.|...
pktksgllstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaak
subfamily_PPM1L_pd Subfamily PPM1L 28-299 4.4e-45 147.0 In-house 11-268 (269) alignment 
Range on Protein: 28-299
Range on HMM: 11-268/269.0
SMQGWRVEMEDAHSAVTGLPHGLKdWSFFAVFDGHAGSKVAKHCSEHILHEITSNPEFLgspkVDGKLNPSTDAVKEGIRTGFLSIDSKMRTDFARtdSS
|..| | .|||     ... .. .  ||||||||| |   |... . . ..| ..   |       | |    . .. .    ||.| |. .   |  . 
svlGrrprmedrfeieediknktg.esffavfdGhGGefaaefakdvlvkaiknkliel....dadkentepinfsklltdeilsvdekllekakr..ae

DKSGSTAVGVIISPKHLFFANCGDSRSVLSRKGEDKPTFsTEDHKPGKPKEMKRIEDAGGSVMIE---RVNGSLAVSRALGDYDYKNNpdkppteQLVSP
| .|.||.  ... ..|  || |||| ||  |      . . |||| ..|| |||..||| . ..   ||.| ||.|||||||  |..       .|| .
diaGttalialvqesdlivanvGdsrGvlydkrGkaipl.sfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdk.......nlvia

EPEVTVFERTDE-EEFIILACDGIWDVMSNEELCQFIRSRLAITDNleeICNQVIETCLQKGSRDNMSIVIVLFQN
.|..  |.  |   ||.|||.||.|| .|||| ..||. ||   |        ..  . ..|| ||.....| ..|
dpdiltfdlddhkpeflilasdGlwdtfsneeavrfikerlkepdf...GakslvlesfkrGsvdnitvlvvklkn
subfamily_ILKAP_pd Subfamily ILKAP 29-296 4e-44 143.9 In-house 12-291 (293) alignment 
Range on Protein: 29-296
Range on HMM: 12-291/293.0
MQGWRVEMEDAHSAVTGLP-------HGLKDWSFFAVFDGHAGSKVAKHCSEHILHEITSNpefLgsPKvdGKLNPSTDAVKEGIRTGFLSIDSKMRTDF
 .| | ||.|||  .  |          ..  |..|||||||||. .....|.. ..| ..   |  ||  ....  .  .|  .   |   |... .  
rkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkilek...l..pk..sdvsakekeikkclvdsfkktdeefLkla

ARTDSSDKSGSTAVGVIISPKHLFFANCGDSRSVLSRKGEDKPTF----STEDHKPGKPKEMKRIEDAGGSVMIERVNGSLAVSRALGDYDYKNNPdkpp
...  . | ||||. |..  . |. || |||..|| || |.  ..     | ||.| | .| |||. |||.|   ||.| | |||..||  .|.      
skakPvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfkrlG....

teqlVSPEPEVTVFERTDEEEFIILACDGIWDVMSNEELCQFIRSRLAITD----------------NLEEICNQVIETCLQKGSRDNMSIVIVL
    |.  |.|.  | |. . |..|||||.|.|.|..|  .|| . |   .                ..| .||..    ...|| ||.....| 
....vistPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrkikeeekkskeevrfevacnrlaseavkrgssdnvtvllvk
subfamily_PP2D1_pd Subfamily PP2D1 32-79 6.5e-06 18.1 In-house 13-58 (492) alignment 
Range on Protein: 32-79
Range on HMM: 13-58/492.0
WRVEMEDAHSAVTGLPHGlKDWSFFAVFDGHAGSKVAKHCSEHiLHEI
|. .|||..  .        . .||...||. |.  |. .... |||.
WKskmeDkrtlqdyfgnd.vnscFfgiyDGynGataAeiaake.lhev
subfamily_KAPP-like_pd Subfamily KAPP-like 35-295 1.3e-25 83.0 In-house 11-264 (266) alignment 
Range on Protein: 35-295
Range on HMM: 11-264/266.0
EMEDAHSAVTGLPHGLK-----DWSFFAVFDGHAGSKVAKHCSEHILHEITsnpEFLGSPKVDGKLNPSTDAvKEGIRTGFLSIDSKMRtDFartdssDK
|||| . |.  | .  |     . ..|||||||||  .|.  .. . .|.    . | | | |   ..  |  .. ..  | ..|.|.. ||      . 
emedvslaiypllkekklsncsnialfavfdGhaGkGaadaakklfpkele...kllkstkqddGGdniydq.skllenafkevdaklk.df......ey

SGSTAVGVII----SPKHLFFANCGDSRSVLSRKGEDkpTFSTEDHKPGKPKEMKRIEDAGGSVM--IERVNGsLAVSRALGDYDYKNNPDKPPTEQLVS
 |.||  ...      ..|  || ||| . |||  |    . . |||  .|.| .|| | | ..     |.|| |||||||||.  |.      .|  ||
eGatatlalvwsdGqqrylqvanvGdssaflsrGnes..lelskdhkakdpeekqrikddGitlsdnqtrinG.lavsralGdhfikelniGlisepyvs

PEPEVTVFertdeEEFIILACDGIWDVMSNEELCQFIRSRLAITDNLEEICNQVIETCLQK-GSRDNMSIVIV
..  .| |     ..|.|.| ||.|||.| ..  . ..|     .  ..... ..|| .|   ..||.|...|
nrilltpf.....dkflivasdGlwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivv
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 35-295 5.1e-23 74.3 In-house 10-274 (276) alignment 
Range on Protein: 35-295
Range on HMM: 10-274/276.0
EMEDAHSAVTGLPHGLK-----DWSFFAVFDGHAGSKVAKHCSEHILHEIT----SNPEFLGSPKVDGklNPSTDaVKEGIRTGFLSIDSKMRtDFARTD
|||| . |.  | .  .     . ..|||||||||  .|.  .. . .|.     |    |   .  |  ..  |  .. .   |  .|.|.. ||    
emedvslaiyplldekdlsncsnialfavfdGhaGkGaadaakklfpkelekllksgnysltkqddGG..dniyd.qskllldlfkevdaklk.dfeyeG

-SSDKSGSTAVG---VIISPKHLFFANCGDSRSVLSRKGEDkpTFSTEDHKPGKPKEMKRIEDAGGSVM--IERVNGsLAVSRALGDYDYKNNPDKPPTE
 ..  .     |        ..|  || ||| . |||  |    . . |||   |.|..|| | | ..     |.|| |||||||||.  |.      .|
atatlalvwsdGeeqqqqqqrylqvanvGdssaflsrGnes..lelskdhkatdpeekqrikddGitlsdnqtrinG.lavsralGdhfikelniGlise

QLVSPEPEVTVFertdeEEFIILACDGIWDVMSNEELCQFIRSRLAITDNLEEICNQVIETCLQK-GSRDNMSIVIV
  ||..  .| |     ..|.|.| ||.|||.| ..  . ..|     .  ..... ..|| .|   ..||.|...|
pyvsnrilltpf.....dkflivasdGlwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivv
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 48-206 1.2e-18 60.6 In-house 15-182 (292) alignment 
Range on Protein: 48-206
Range on HMM: 15-182/292.0
HGLKDWSF-FAVFDGHA--GSKVAKHCSEHILHEITSnpeflgspkvdgkLNPSTDAVKEGIRTGFLSIDSKMRTDFArtDSSDKSGSTAVGVIISPK-H
.| .  .|  ||.|||   | |||.   ... .|...             | .   .. | .  . |.| .|..  ..  |   ......|  ..     
egsealtflaavldGhGvnGdkvaqlaedtlevelle.............ltrqlqelsealllrildiaakldklti..daresattavvcarvrddra

LFFANCGDSRSVLSR---KGEDKPTFSTEDHKPGKPKEMKRIEDAGGSVMI-----------ERV------NGSLAVSRALGD
|. || ||||..| |     . ..   . ||||  | | .||  ||| |              ||      .| ||.||||||
lilanvGdsrallgrclggsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGd
PP2C_2 Protein phosphatase 2C 50-263 6.7e-07 21.8 Pfam-A 21-194 (212) alignment 
Range on Protein: 50-263
Range on HMM: 21-194/212.0
LKDWSFFAVFDGHAGSKVAKHCSEHILHEITSNPEFLGspkVDGKLNPsTDAVKEGIRTGFLSI-DsKMRTDFARTDSSDKSGSTAVGVIISPKHLFFAN
 .|....|| ||.   | ... ..   . ...  | |     .....  ..|. . |... | . . .     |.  . .. ..| . ..|.|....|..
asdgwllaVADGaGsakrSdkGarlaveaagealekll...eeeseqe.eeallrqieneilasvk.lkqeaeaqqeelkdyatTlllavitpgeivffq

CGDSRSV-LSRKGEDKPTFSTEDHKPGkpKEMKRIEDA--GGSVmiervngslavsralgdydyknnpdkppteqlvspepEVTVFErTDEEEFIILACD
.||.. |  .| || .. .. . ..     |  .. ..  ....                                     ..  .. ... . ..|  |
iGDgaivvrdrdgevqllgepdsgeya..nettfltsedaeeel.....................................rirrlk.lepgdalllmTD

GIWDVMSNEE-LCQFIRSR
|..| ...|| . .... .
Gvsdslrkeepfrellael
PP2C_2 Protein phosphatase 2C 50-263 6.7e-07 21.8 In-house 21-194 (212) alignment 
Range on Protein: 50-263
Range on HMM: 21-194/212.0
LKDWSFFAVFDGHAGSKVAKHCSEHILHEITSNPEFLGspkVDGKLNPsTDAVKEGIRTGFLSI-DsKMRTDFARTDSSDKSGSTAVGVIISPKHLFFAN
 .|....|| ||.   | ... ..   . ...  | |     .....  ..|. . |... | . . .     |.  . .. ..| . ..|.|....|..
asdgwllaVADGaGsakrSdkGarlaveaagealekll...eeeseqe.eeallrqieneilasvk.lkqeaeaqqeelkdyatTlllavitpgeivffq

CGDSRSV-LSRKGEDKPTFSTEDHKPGkpKEMKRIEDA--GGSVmiervngslavsralgdydyknnpdkppteqlvspepEVTVFErTDEEEFIILACD
.||.. |  .| || .. .. . ..     |  .. ..  ....                                     ..  .. ... . ..|  |
iGDgaivvrdrdgevqllgepdsgeya..nettfltsedaeeel.....................................rirrlk.lepgdalllmTD

GIWDVMSNEE-LCQFIRSR
|..| ...|| . .... .
Gvsdslrkeepfrellael
PP2C_SIG_SM00331 82-295 1e-13 44.4 In-house 63-215 (217) alignment 
Range on Protein: 82-295
Range on HMM: 63-215/217.0
NpeflgspkvdgklnpstdavkEGIRTGFLSIDSKMRTDfartDSSDKSGSTAVGVI--ISPKHLFFANCGDSRSVLSRkgEDKPTFSTEDhkpgkpkem
.                     | . . .  ... ..      .  . .. |..  .  .| ..| .||.|||| .| |  ..| .. ..|         
g.....................eelsqalkrlnraiyee....keekgmfaTlllalydfssgklsyanaGdsrpyllr..dgklveilkd.........

kriedaggsvmiervngslavsralgdydyknnpdkpPTEQLVSPEPEVT--VFERT-DEEEFIILACDGIWDVM-----SNEELCQFIRSRLaiTDNLE
                                     .. .... ||||.  . |.. .......|. ||.....      .|.|...... .  .. ..
.....................................vegaplGlepevsvdirelelekgdllllytDGltearsekgfaeerleeiledlv..dseaq

EICN----QVIETCLQKGSRDNMSIVIV
|. .    ...|.  ... .|....|.|
elaqkiveellelakgsngeDdiTvvvv
subfamily_PDP_pd Subfamily PDP 93-286 1.1e-23 77.0 In-house 106-334 (398) alignment 
Range on Protein: 93-286
Range on HMM: 106-334/398.0
GKLNPSTDAVKEGIRTGFLSIDSKMRTDFA---RTDSSD------KSGSTAVGVIISPKHLFFANCGDSRSVLSRKGEDK---PTFSTEDHKPGKPKEMK
 .|. ... ||| ....||..|. ..|.     .  |..       ||..|. . |....|. || ||.|.|| .. |.     .  ..|.    ..|..
elleaevekvkealkkaFlklDkdistealkklkekslreallvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEve

RIEDAG------GSVMIERVNGSLAVSRALGDYDYKNNP--DK-----------PP----TEQLVSPEPEVTVFERTDEEEFIILACDGIWDVMSNEELC
||. .         .. .|. |.|. .|| ||. || .   .|           .|    |   .. |||||  . . .. |..|| ||.||..||||  
RikkeHPgeesktvirngRlLgeLqPlRAFGdvryKwseelqkkvlekaylkvlepkdyktPPYltaePevtshklrendkFLvlatDGLwdllsneevv

QFIRSRLAITDNLEEICNQVIETCLQKGS
. .   || ... |..  .  .. |.. .
slVgehlakkkekepvkveeakltlkqvv
subfamily_PPM1H_pd Subfamily PPM1H 102-173 3.5e-08 25.6 In-house 136-203 (404) alignment 
Range on Protein: 102-173
Range on HMM: 136-203/404.0
VKEGIRTGFLSIDSKMRTDfaRTDSSDKSGSTAVGVIISPKHLFFANCGDSRSVLSRKGEDKPtFSTeDHKP
|.  . . ||..|.... .  |..  .| | ||. ...  . |. || ||||..|.||.| .| .|. |. |
viGalesaflemDeqiare..reayrikGGCtalvalvllgklYvanaGDsRailvrkdeiip.lsa.dftP
subfamily_PPM1G_pd Subfamily PPM1G 126-299 5.8e-52 170.2 In-house 292-472 (473) alignment 
Range on Protein: 126-299
Range on HMM: 292-472/473.0
SSDKSGSTAVGVIISPKHLFFANCGDSRSVLSRKGEDKPtFStEDHKPGKPKEMKRIEDAGGSVMI-ERVNGSLAVSRALGDYDYKNNPDKPPTEQLVSP
   .||.||| ...  |.|. || ||||.||||.|.    .| .||||  ..|..||| ||| |    |||| | .||||||. ||.| . |. ||..| 
pGedsGttAvvaLlkekklivAnaGDsRcvlsrnGkAld.ls.lDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplkeqmisA

EPEVTVFERTDEEEFIILACDGIWDVMSNEELCQFIRSRLAITD--NLEEICNQVIETCLQKGS------RDNMSIVIVLFQN
 |.. | . |.|.||..|||||||.||. .|  .|.|..|. ..   |.||.......|| .         |||...|||...
lPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtviivllkk
subfamily_PP2D1_pd Subfamily PP2D1 128-267 1.7e-20 66.2 In-house 175-309 (492) alignment 
Range on Protein: 128-267
Range on HMM: 175-309/492.0
DKSGSTAVGVIiSPKHLFFANCGDSRSVLSRKGedKPTFSTEDHKPGKPKEMKRIEDAGGSVM----IERVNGSLAVSRALGDYDyknnpdKPPTEQLVS
..| .. |  .  .  |. || |. . || |.|  |    | .| |. .|| .|.| ||..|.      .||| | . | || |        |  .. | 
kesngsevhle.elgvlyianaGnvqAvLcreG..kaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyG......dpkLkksvi

PEPEVTVFERTDEEEFIILACDGIWDVMSNEELCQFIRSRLAIT
|||..|  . ...  |..||  |.|.|.|.||  . ... ||| 
pePkttsvkldeaaqflvlAsnGlWevlseeevlsLvkqtlaiy
subfamily_TAB1_pd Subfamily TAB1 130-251 3.6e-11 35.4 In-house 129-260 (333) alignment 
Range on Protein: 130-251
Range on HMM: 129-260/333.0
SGSTAVGVIISPKHLFFANCGDSRSVLSR-KGEDKPTFSTEDHKPGKPKEMKRIEDAGGS-VMI--ERVNGSLAVSRALGDYDYKNNPD-----KPPTEQ
 |.||| ..|  ..|. ||.|||| .| . | ..| .    ||.   ..|..|..| |     |   .. ||    |..|||  |.  .     .  ...
gGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkkgykdvdilssakge

LVSPEPEVTVF-ERTDEEEFIILACDGIWDVM
 |  ||...   . .| . |..|  ||.   .
PviaePdiqgaypiddityflvlmSdGvyktL
subfamily_PHLPP_pd Subfamily PHLPP 143-296 2.2e-09 29.6 In-house 106-244 (246) alignment 
Range on Protein: 143-296
Range on HMM: 106-244/246.0
HLFFANCGDSRSVLSRKGEdKPTFSTEDHKPGKpkEMKRIEDAGGSVMIE-RVNGSLAVSRALGDYdYkNNPdkppteqLVSPEPEVTVFERTDEEEFII
 |  |. |   .|| |.|. | ..| ..       |.||| .| . .  . ..|| .. .| || . .   |        | |.|.|     |...|..|
sLevAsvGtlqavliRngk.klrlsksyviekd..elkrikeakaiitednkingviestrllGyt.f.lfP.......vvlPkphvrevlLteqdelli

LACDGIWDVMSNEELCQFIRSRlaiTDNLeEICNQVIETCLQKGSRDNMSIVIVL
.  . .|.|.| .|. . .|      | |  .  ....     | .|..|...| 
vGnkalWevlsideaveavrke...edpl.vaAkklvdlaqsygaadsvsvlvvr
subfamily_PPM1H_pd Subfamily PPM1H 192-269 8.2e-12 37.6 In-house 275-356 (404) alignment 
Range on Protein: 192-269
Range on HMM: 275-356/404.0
ERVNGSLAVSRALGDYDYKNNPDKPPTEQLVSPEPEVTVFERT----DEEEFIILACDGIWDVMSNEELCQFIRSRLAITDN
 |. . ..|.| |||.. |    .     ..||.|||.|.. |    .|.. .||| ||.|||.||||  . .|. |. ...
aRllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskvep
subfamily_PPM1D_pd Subfamily PPM1D 198-298 2.5e-15 49.4 In-house 201-308 (309) alignment 
Range on Protein: 198-298
Range on HMM: 201-308/309.0
LAVSRALGDY-DYKNNpdkpPTEQLVSPEPEVTVFERTDEEE-FIILACDGIWDVMSNEELCQFIRSRLAITDNL----EEICNQVIETCLQKGSR----
|||.|.|||   |...      | .|||||.|.|.... .|| ||||| ||.|.|.. |.  .....  ...       ... ...... ||. ..    
LavaRslGDlWsynak....sgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklr

-DNMSIVIVLFQ
 ||.|...|...
aDnvsvivvile
PPM_PTC7_SpoIIE_motif 236-295 6.7e-11 35.7 In-house 11-78 (81) alignment 
Range on Protein: 236-295
Range on HMM: 11-78/81.0
EEEFIILACDGIW-------DVMSNEELCQFIRSRlaITDNLEEICNQVIETCLQKG---SRDNMSIVIV
. . ..|..||..       .....|||.......     .|.|.. ......|. |   ..|.......
pgdvllLyTDGltEardsdgelfgkeellrladra..egkslqeladklvdevlengsgereDDitllvl
PPM_PTC7_motif 241-290 1.1e-17 57.3 In-house 1-51 (51) alignment 
Range on Protein: 241-290
Range on HMM: 1-51/51.0
ILACDGIWDVMSNEELCQFIRSRLAI-TDNLEEICNQVIETCLQKGSRDNM
|||.||.|||.|..|.....|..|.   . ..|.........|..|| ||.
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni
PP2C_C Protein serine/threonine phosphatase 2C, C-terminal domain 291-368 3.1e-26 80.9 Pfam-A 1-80 (81) alignment 
Range on Protein: 291-368
Range on HMM: 1-80/81.0
SIVIVLFQNAPEVSQDALTKEKELDVLLEEKVKEVMENFGDQTQLDL--VMHVLRMADIPGLPPGGGLSAKKGTIEEILN
||..|.| .||.||..|. ||.|||  ||..|.|..|. . . . ||  |...|   |||.|||||||..|.  ||.  .
siilvcfpgAPkvseeAvkkeaeLdkalesrveeiieksseeevpdllsvlktlasedipnLPPGGglasKrsvieavyk