Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
| Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
|---|---|---|---|---|---|---|---|---|---|
| subfamily_PPM1D_pd | Subfamily PPM1D | 1-306 | 3.4e-134 | 439.8 | In-house | 16-308 (309) | alignment | ||
Range on Protein: 1-306
Range on HMM: 16-308/309.0
MEDMICIVFDREQEA---DYACFAVFDGHGGKEAAVYARDHLWQNIKNQDGFFSREPNAVMSAINEAFRVTQEGMWKERSSWPKTLSGYPSTAGSTCSMV
|||...||...|..| ..|..|||||||||||| .||.|||..||.|..|.|.||..|..||.||| |.| |.|....|||| ||..||||.|.|.|
meDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktksgllstaGttasvv
IICGNDMYTAHVGDSRIVLGKSEPrglnttnvygvTSHKIVTETLTVDHKPSDIEEIERIEEAGGRVQDKAGVQRVVWSRPKLDHTGPitrnTELTDIPF
||.....|.||||||.||||..|| . .|.....||.||||...|| |||||.||.|..|.||.||||.||.|.|.|| |....|||
iirreklyvahvGDsaivlgvkep...........kekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngp....tvideiPF
LAVARSLGDLWSYNFRSGKYIVSPEPDIMHRVIDPKSERFLILGSDGLWNMVTSEASVQIVEKYDKTRILQGEQSsETVSHQLVKRGMDLWNYHLLRADN
||||||||||||||..||...||||||...|..||..|.|.||.||||||..|.|..|..|||......|..||| ..|...|||.... |... |||||
LavaRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqs.rsvakalvkealqrwrskklraDn
ISVICVFFE
.|||.|..|
vsvivvile
|
|||||||||
| PP2Cc_SM00332 | 1-303 | 4.6e-53 | 173.4 | In-house | 24-274 (274) | alignment | |||
Range on Protein: 1-303
Range on HMM: 24-274/274.0
MEDMICIVFDREQEADYACFAVFDGHGGKEAAVYARDHLWQNIKNQDGFFSRE-PNAVMSAINEAFRVTQEGMWKERSSW-PKTlsgypSTAGSTCSMVI
||| ...|.| .|.| . |.|||||||.|.| .....|....|.. . ..| ..| |...||. |.| ...| .|. .. ...|||.....
meDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskelen.....alsGstavval
ICGNDMYTAHVGDSRIVLGKSEPrglnttnvygvtshkivTETLTVDHKPSDIEEIERIEEAGGrvqdkagvqrvvwsrpkldhtgpITRNTelTDIPFL
. ..|.| |.|||||.||.... |.|||||.| .|..||..||| ... |
lkkedlyvanvGDSravlcrngk.................avqlsvdhkpedederkRikkagg.......................vvekg..rvnggl
AVARSLGDLWSYN-FRSGKYIVSPEPDIMHRVIdPKSERFLILGSDGLWNMVTSEASVQIVEKYDKTRilqG----EQSSETVSHQLVKRgmdlwnyhLL
|| |..|| . . . . ....|||. . . ....|||| |||||...... |.||.| ... .. .| . .. .|
avsrafGdhflkknkklkepyitaepdvkvvtl.tsedeflilaSDGlwdvlsnqevvdivrkllakg...ktndpqeaaelldeeairr........gg
RADNISVICV
.|||.|..|
seDniTvvvv
|
|||||||||
| 0034914 | PP2C-like | 1-306 | 1.3e-52 | 171.5 | In-house | 35-291 (295) | alignment | ||
Range on Protein: 1-306
Range on HMM: 35-291/295.0
MEDMICIVFDREQ-EADYACFAVFDGHGGKEAAVYARDHLWQNIKNQ----DGFFSREPNAVMSAINEAFRVTQEGMWKERSSWpktlsGYPSTAGSTCS
.|| ...|.. . |...|.||||||| .|| .|...|....... . . . ... ...|. .|| ..| .... .. . .. |.|..
neDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellelallr.....pelagsGtTav
MVIICGNDMYTAHVGDSRIVLGKSEPRglnttnvygvtshkivtETLTVDHKPSDIEEIERIEEAGGRVQDkagvQRVVwsrpkldhtgpitrnteltdi
...|.|| .|.|.|||||.|| .. . |||||||.. .|.|||..|||.|.. ||
valirgnklyvanvGDSravllrngel.................vqltvdhkpvnelererilsaggavsh....grvn.....................
PFLAVARSLGDLWSY---NFRSGKYIVSPEPDIMHRVIDPKSERFLILGSDGLWNMVTSEASVQIVEKYDKtrilqGEQSSETVSHQLVKRGMDlwnyhL
..||| |.||| . . .. ...||.|||.... ..... ||.|.|||||.....| |.|| .. . . .. | ....||.. ..
gvlavtRalGdfdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrslla.....kgldleeaaeeLvdlAla.....r
LRADNISVICVFFE
|||.|..|...
gsrDNiTvvvvrln
|
|||||||||
| subfamily_PPM1A_pd | Subfamily PPM1A | 1-306 | 3.6e-41 | 134.4 | In-house | 26-281 (282) | alignment | ||
Range on Protein: 1-306
Range on HMM: 26-281/282.0
MEDMICIVFDREQEADYACFAVFDGHGGKEAAVYARDHLWQNIKNQDGFF-----SREPNAVMSAINEAFRVTQEGMWKErSSWpktLSGYpSTAGSTCS
||| ..| . .. .| . |||||||.|.|.| |. .|| .|| ... . ..| ..| .|....| ..| . .. |.. |.. .|||.
mEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairel.std...lkta.dksGsTav
MVIICGNDMYTAHVGDSRIVLGKSEprglnttnvygvtshkiVTETLTVDHKPSDIEEIERIEEAGGRVQdkagVQRVVWSrpkldhtgpitrnteltdi
.|.. . ...|..||||.|| . . .. || |||||. .| .|||.||| | |.|| .
tvlvsekhliianlGDsRavlcrng.................kaaflteDHkpsrpkEkkRieqAGGsvv....vsRvnGa...................
pfLAVARSLGDLWSYN---FRSGKYIVSPEPDIMHRVIDPKSErFLILGSDGLWNMVTSEASVQIVEKydktRILQGeQSSETVSHQLVKRGmdlwnYHL
|||.|.||| . .. . ||.||... .. . . ||.| .||.| ....| |..|.| |. .. . |.|...||.. ..
..LAvsRalGDyeykeeeekkaeeqlvsaepevtsierseedd.flvlacDGiwDvlsdeevvelvrk....rleva.deleevakalvdka.....lek
LRADNISVICVFFE
||.||. |.|.
gsrDNlsvlvvlfa
|
|||||||||
| 0049733 | PP2C-like | 1-306 | 8.3e-39 | 126.3 | In-house | 18-234 (235) | alignment | ||
Range on Protein: 1-306
Range on HMM: 18-234/235.0
MEDMICIvfdreqeaDYACFAVFDGHGGKEAAVYARDHLWQNIKNQdgFFSREPNAVMSAINEAFRVTQEGMWKERSSWPktlsgYPSTAGSTCSMVIIC
.|| ... ....|||.||||| .|. .|...|....... . . .. .. |. .||. ..| .... ..| .. |.|.......
neDavlv........glllfavaDGhgghaagevasellvetllel..llelllldleealrkaflaaneallelalasp.....elagmgtTavvalld
GNDMYTAHVGDSRIVLGKSEprglnttnvygvtshkiVTETLTVDHKPSDIEEIERIEEAGGRVqdkagvqrvvwsrpkldhtgpitrntelTDIPFLAV
|. .|.|.|||||..| ... . ||.||.|.. .| .||..|||.| . .. ||.
ggklyvanvGDsrayllrdg.................klvqltedhspvnelerqriitaggav............................rvpgrlal
ARSLGDLWSYnfrsgkyivspePDIMHRVIDPKSerFLILGSDGLWNMVTSEASVQIVEKydktrilqgeQSSETVSHQLVKRGMDLWNYhllraDNISV
|.||||. ||... ..| ||.| |||||.....| |... . .. | . ..||.. .. . . |||.|
tralGdlllk............pdvtvlelepgd..flllasDGlwdvlsdeeivdllrs..........ldleeaaerlvelalarggr.....DNiTv
ICVFFE
..|...
vvvrld
|
|||||||||
| subfamily_LRR-PP2C_pd | Subfamily LRR-PP2C | 1-284 | 5.9e-33 | 107.2 | In-house | 20-241 (255) | alignment | ||
Range on Protein: 1-284
Range on HMM: 20-241/255.0
MEDMICIV--FDREQEADYacFAVFDGHGGKEAAVYARDHLWQNIKNQDGFFSREPnavMSAINEAFRVTQEGMwkersswpktlSGYPSTAGSTCSMVI
||| . | | ... || .|.||||||..|| .| ..| . ... .. .| . ....|.. .. . | .| |.| |.
medelviyGsfrdksdedy..yalfdGhgGraaakfaseelykilaelldlnnanP...vkslkkaykeistqi...........serpkfiGttaasvl
ICGNDMYTAHVGDSRIVLGkseprglnttnvygvtSHKIVTETLTVDHKPSDIEEIERIEEAGGRVQDKagvqrvvwsrpkldhtgpitRNTELTDiPFL
|... .| | |||||.||. .. ... |..|||||. .| .||.|.|| | . . | . |
iiedkvyianvGdsrvvlc................qkdgtakrlsldhkPseeseekriselGGtvvst....................vvtsrvn.Gtl
AVARSLGDLWSYNFrsgkyiVSPEPDIMHRVIDPKSERFLILGSDGLWNMVTSEASVQIVEKYDKTrilqgEQSSETVSHQLVKRG
||.|.||| . | | |.||. . . |...|||| ||.|.... | .|.|| . .. |...|.. . ..|
avsralGdsflePf......vvpdPdlsqsleiskkdkflilacdGiwdlisdeeaveivagisdp.....ekaaeklrdlayssG
|
|||||||||
| subfamily_PPM1L_pd | Subfamily PPM1L | 1-173 | 4.1e-17 | 55.3 | In-house | 19-172 (269) | alignment | ||
Range on Protein: 1-173
Range on HMM: 19-172/269.0
MEDMICIVFDREQEADYACFAVFDGHGGKEAAVYARDHLWQNIKNQDGFFSREPNAvMSAINEAFRVTQEGMWKERSSWPKTLSGYpSTAGSTCSMVIIC
||| . | | ..... |||||||||. || .|.| | ..|||. . .. . || . .|.| . .. |. . . .||.|. . ..
medrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadken.tepinfsklltdeilsvdekllekakrae.diaGttalialvq
GNDMYTAHVGDSRIVLGKSEprGlnttnvygvtsHKIvteTLTVDHKPSDIEEIERIEEAGGRVQDKaGVQRV
..|. | ||||| || . | . | |. |||| ...| ||..||| . . || ||
esdlivanvGdsrGvlydkr..G...........kai...plsfdhkpqqvkerkrikkaGGfiafr.Gvwrv
|
|||||||||
| subfamily_PPM1G_pd | Subfamily PPM1G | 1-66 | 6e-11 | 35.0 | In-house | 33-93 (473) | alignment | ||
Range on Protein: 1-66
Range on HMM: 33-93/473.0
MEDMICIVFDREQeaDYACFAVFDGHGGKEAAVYARDHLWQNIKNQDGFfsrEPNAVMSAINEAFR
.|| . . | .. | ..|||.||||||| |.| ..| . .|.| |. . . | .|..|||
qEDahncitdlde..dtslfavyDGHGGkevakyvakklpdllkaqkgy...kegdvekaleeafl
|
|||||||||
| subfamily_PPM1G2_pd | Subfamily PPM1G2 | 2-305 | 1e-35 | 116.1 | In-house | 34-286 (287) | alignment | ||
Range on Protein: 2-305
Range on HMM: 34-286/287.0
EDMICI---VFDREQEADYACFAVFDGHGGKEAAVYARDHLWQNIKNQDGFFsrePNAVMSAINEAFRVTQEGMWKErsswpKTLSGypSTAGSTCSMVI
|| . ....... . | |||||||||...| || .| . |.... | .|. ....|| | | . |. ..|. ..||||. .|.
eDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfk...egaleqilkdafletDeellkd.....eklkd..esaGstavvvl
ICGNDMYTAHVGDSRIVLgkseprglnttnvygvtSHKIVTETLTVDHKPSDIEEIERIEEAGGRVQDKAGVQRVVWSRPKLDHTGPITRNteltdipfl
| ...| | .|||| || |.|. ...|..||||....| .||..||| |. . . . || |.. . .
ikeeklyvanaGDsravl.................sskgnvkalsfDhkPqeesekkriiaagGfvelnrvngnLalsralgDfefkknvk.........
avarslgdlwsynFRSGKYIVSPEPDIMHRVIDpKSERFLILGSDGLWNMVTSEASVQIVekydKTRILQGeQSSETVSHQLVKRGMDLWNY-HLLRADN
.. || .||.. . .| ... ||.| ||.|...|.. |..| ..|. .| .. ......|..... . . .||
.............kkpeeqivtavPDvlvkkld.eddeflvLaCDGiWDvltnkevvdlv....rerlvsg.akldeiieelldkclapdssntgvGcDn
ISVICVFF
..|. | .
mtvvivvl
|
|||||||||
| subfamily_PPM1K_pd | Subfamily PPM1K | 2-260 | 3.3e-15 | 48.9 | In-house | 19-227 (263) | alignment | ||
Range on Protein: 2-260
Range on HMM: 19-227/263.0
EDMICIvfdREQEADYACFAVFDGHGGKEAAVYARDHLWQNIKNqdgFFSREPNaVMSAINEAFRVTQEGMWKER-SSWPKTlsgYPSTAGSTCSMVII-
|| |.. .| . . .||||||.| || .. |.| . .|. .. .| . . ...|| .. . . |.... ..|.| .....
edrikl...keldpellyvavfdGhaGsaaadfvhdklekilkr...llekekd.leivlknafeeldkklkrylefsvaea...ellssGttatvsllr
CGNDMYTAHVGDSRIVLGKseprglNttnvyGVtshkivTETLTVDHKPSDIEEIERIEEAGGRVQDKAGVQRVVWSRpkldhtgpitrnteltdipfLA
|... | .|||| .| . | | .. || ||.|. || ||| .|||.|. .. . | .| ||
dGtelvlaslGdsrailcr......n.....Gk......akkltrdhdPeleeekerikaagGsvewnslgkplvngr....................la
VARSLGDLwsyNFRsgKYIVSPEPDIMHRVIDPKSERFLILGSDGLWNMVTSEASVQIVEK
..|||||| ... .| | .|. . .| ... ||.| .||. ..|.|. ..|..
mtrslGdl...dlk..ryGviatPetkslkvdhaadsflvlitdgisfvvnsqelcdlvrl
|
|||||||||
| subfamily_PPM1E_pd | Subfamily PPM1E | 7-173 | 1e-22 | 73.6 | In-house | 30-167 (265) | alignment | ||
Range on Protein: 7-173
Range on HMM: 30-167/265.0
IVFDREQEADYACFAVFDGHGGKEAAVYARDHLWQNIKNQDGFfSREPNavmSAINEAFRVTQEGMWKErSSWpKTLsgypsTAGSTCSMVIICGNDMYT
.|. ..| ..| ||||||||| ||| || ||.... .| . ..| .|..|||..| | . . . ..| ..||| .|.| .. .|
elfelkdekeraffavfDGHgGveaakyaaahlhellvrqekl.kedpa...ealkeafkltDerflqk.aer.ekl.....ksGstavvvliekdqlyv
AHVGDSRIVLgkseprglnttnvygVtsHKIVTETLTVDHKPSDIEEIERIEEAGGRVQDKaGVQRV
| .|||. .| | .|. . .|. |||.. .| .||||||| | |. ||
aWlGDsqall...............v..rkgeavqlmkpHkPeredEkkRieeagGlvvvi.gawRv
|
|||||||||
| subfamily_PPM1H_pd | Subfamily PPM1H | 11-46 | 3.3e-06 | 19.1 | In-house | 56-91 (404) | alignment | ||
Range on Protein: 11-46
Range on HMM: 56-91/404.0
REQEADYACFAVFDGHGGKEAAVYARDHLWQNIKNQ
.|.....|.|..||||.|. ||. | | . .|..
eeeklplayfglfDGhaGsgaalvaskllhkhlkek
|
|||||||||
| PP2C | Protein phosphatase 2C | 13-283 | 1.4e-57 | 188.2 | Pfam-A | 30-245 (255) | alignment | ||
Range on Protein: 13-283
Range on HMM: 30-245/255.0
QEADYACFAVFDGHGGKEAAVYARDHLWQNIKNQDGFFSREpnAVMSAINEAFRVtQEGMWKERsswPKTLSgYPSTAGSTCSMVIICGNDMYTAHVGDS
.. . | ||||||||| ||| ||| ||.. .|.|. | . | | |....|. .. ..... .|. . ||. |||.....| |...|.|.||||
gkssvaffavfdghggreaakyarehleeilkeqksflele..kvekalrksfla.dtdeelks...skant.epsksGstavvalirgkklyvAnvGDS
RIVLGKSEPRGlnttnvygvtshkivtETLTVDHKPSDIEEIERIEEAGGRVQDkagVQRVVWSrpkldhtgpitrnteltdipfLAVARSLGDLWSYNF
|.||... .||.|||||| .|.||||||||.|.. ..||..| |||.|.|||......
ravLcrkdnak................keltedHkpsdedEreRIeeaggsvsn...ngrvngs.....................LavsRalGdfelkpk
RsgKYIVSPEPDIMHRVIDPKsERFLILGSDGLWNMVTSEASVQIVEKY-DKTRilqgeqSSETVSHQLVKR
...||.|||. .. .... . ||||.|||||...... |..|.. .|.. | .... .||.
e..eqlvsaePdvtsvkltee.defliLasdGlwdvlsdqeavdlvrselskkk......spmeaaeelvde
|
|||||||||
| PP2C | Protein phosphatase 2C | 13-283 | 1.4e-57 | 188.2 | In-house | 30-245 (255) | alignment | ||
Range on Protein: 13-283
Range on HMM: 30-245/255.0
QEADYACFAVFDGHGGKEAAVYARDHLWQNIKNQDGFFSREpnAVMSAINEAFRVtQEGMWKERsswPKTLSgYPSTAGSTCSMVIICGNDMYTAHVGDS
.. . | ||||||||| ||| ||| ||.. .|.|. | . | | |....|. .. ..... .|. . ||. |||.....| |...|.|.||||
gkssvaffavfdghggreaakyarehleeilkeqksflele..kvekalrksfla.dtdeelks...skant.epsksGstavvalirgkklyvAnvGDS
RIVLGKSEPRGlnttnvygvtshkivtETLTVDHKPSDIEEIERIEEAGGRVQDkagVQRVVWSrpkldhtgpitrnteltdipfLAVARSLGDLWSYNF
|.||... .||.|||||| .|.||||||||.|.. ..||..| |||.|.|||......
ravLcrkdnak................keltedHkpsdedEreRIeeaggsvsn...ngrvngs.....................LavsRalGdfelkpk
RsgKYIVSPEPDIMHRVIDPKsERFLILGSDGLWNMVTSEASVQIVEKY-DKTRilqgeqSSETVSHQLVKR
...||.|||. .. .... . ||||.|||||...... |..|.. .|.. | .... .||.
e..eqlvsaePdvtsvkltee.defliLasdGlwdvlsdqeavdlvrselskkk......spmeaaeelvde
|
|||||||||
| PP2C_2 | Protein phosphatase 2C | 13-252 | 5.2e-07 | 22.2 | Pfam-A | 20-184 (212) | alignment | ||
Range on Protein: 13-252
Range on HMM: 20-184/212.0
QEADYACFAVFDGHGGKEAAVYARDHLWQNIknqDGFFSREPNAVMSA-INEAFRVTQEGMWKERSSWPKTL--SGYPSTAGSTCSMVIICGNDMYTAHV
...|. ..|| ||.| . . . . ... ... .. . . .....| ..... .... . . .. ..|.....|... .. ...
easdgwllaVADGaGsakrSdkGarlaveaa...gealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavitpgeivffqi
GDSRIVLG--KSEPRGLNTTNVYGVTSHkivTETLTVDHKPSDIeeierieeaggrvqdkagvqrvvwsrpkldhtgpitrnteltdipflavarslgdl
||..||. .| . |.. . . .. | || . ..
GDgaivvrdrdgevqllgepdsgeyane...ttfltsedaeeel........................................................
wsynfrsgkyivspepdiMHRVIDPKSERFLILGSDGLWNMVTSE
.| .. .. . |.| .||.......|
..................rirrlklepgdalllmTDGvsdslrke
|
|||||||||
| PP2C_2 | Protein phosphatase 2C | 13-252 | 5.2e-07 | 22.2 | In-house | 20-184 (212) | alignment | ||
Range on Protein: 13-252
Range on HMM: 20-184/212.0
QEADYACFAVFDGHGGKEAAVYARDHLWQNIknqDGFFSREPNAVMSA-INEAFRVTQEGMWKERSSWPKTL--SGYPSTAGSTCSMVIICGNDMYTAHV
...|. ..|| ||.| . . . . ... ... .. . . .....| ..... .... . . .. ..|.....|... .. ...
easdgwllaVADGaGsakrSdkGarlaveaa...gealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavitpgeivffqi
GDSRIVLG--KSEPRGLNTTNVYGVTSHkivTETLTVDHKPSDIeeierieeaggrvqdkagvqrvvwsrpkldhtgpitrnteltdipflavarslgdl
||..||. .| . |.. . . .. | || . ..
GDgaivvrdrdgevqllgepdsgeyane...ttfltsedaeeel........................................................
wsynfrsgkyivspepdiMHRVIDPKSERFLILGSDGLWNMVTSE
.| .. .. . |.| .||.......|
..................rirrlklepgdalllmTDGvsdslrke
|
|||||||||
| PPM_PTC7 | 14-261 | 1.8e-57 | 187.7 | In-house | 31-233 (259) | alignment | |||
Range on Protein: 14-261
Range on HMM: 31-233/259.0
EADYACFAVFDGHGGKEAAVYARDHLWQNIKNQDGFFSREpnAVMSAINEAFRVTQEGMWKERsswPKTLSgYPSTAGSTCSMVIICGNDMYTAHVGDSR
. . | ||||||||| ||| ||| ||.. .|.. | . | . |....|. . ..... ... . ||| |||.....| |...|.|.|||||
kdsvaffavfdghggreaakyarehleeilkerksfeele..klekalrksflaldtdeelks...seant.epstsGstAvvalitgsklyvAnvGDSr
IVLGKSEPRGlnttnvygvtshkivtETLTVDHKPSDIEEIERIEEAGGRVQDKaGVQRVVWSrpkldhtgpitrnteltdipfLAVARSLGDLWSYNFR
.||..|. .||.|||||. .|.||||.|||.| .. |..||... |||.|..||......
avLcrsgnav................kqltedHkpsnedEreRiegaggsvsnv.gngrvngv.....................lavsRafGdfelkpke
SGKYIVSPEPDIMHRVIDPKsERFLILGSDGLWNMVTSEASVQIVEKY
... ||.|||| .. ||.. . ||||.|||||..|... |..| .
teeqlvsaePdisstkidee.defliLasdGlwdvvsdqeavdlvrse
|
|||||||||
| PP2C_SIG_SM00331 | 15-304 | 4.3e-10 | 32.5 | In-house | 28-216 (217) | alignment | |||
Range on Protein: 15-304
Range on HMM: 28-216/217.0
ADYACFAVFDGHG-GKEAAVYARD--HLWQNIKNQDgffsREPNAVMSAINEAFRVTqegmwkersswpktlsGYPSTAGSTCSMVII--CGNDMYTAHV
... ..|.||.| |..||.... .. ... ... |. .....|.|.. . . |. . .. .. .. |..
egrlllvvaDgmGkGlaAaaassqlrtalrellseg....eelsqalkrlnraiyee................keekgmfaTlllalydfssgklsyana
GDSRIVLGKSEPRGLNTTNvygvtshkivtetltvdhkpsdieeierieeaggrvqdkagvqrvvwsrpkldhtgpitrnteltdipflavarslgdlws
||||..| .. . ..
Gdsrpyllrdgklveilkd.................................................................................
ynfrSGKYIVSPEPDIM--HRVIDPKSERFLILGSDGLWNMVTSEAsvqIVEKYDKTRILQgEQssETVSHQLVKRGMD-LWNYHLLR--ADNISVICVF
.... ||... | .. . . .|.| .|||....... . |. ... . . . .. . .| .. .. | .. . |.|.|. |.
....vegaplGlepevsvdirelelekgdllllytDGltearsekg...faeerleeiled.lv..dseaqelaqkiveellelakgsngeDdiTvvvvk
|
|||||||||
| subfamily_Dicty-PPM1L-like_pd | Subfamily Dicty-PPM1L-like | 15-46 | 4.2e-06 | 18.8 | In-house | 35-65 (305) | alignment | ||
Range on Protein: 15-46
Range on HMM: 35-65/305.0
ADYACFAVFDGHGGKEAAVYARDHLwQNIKNQ
. | |||||.|. || |.. .| .| |.
qelslfGvfdGhnGdiaaeyvkkkl.veivnk
|
|||||||||
| subfamily_ILKAP_pd | Subfamily ILKAP | 17-167 | 1.7e-21 | 69.6 | In-house | 43-179 (293) | alignment | ||
Range on Protein: 17-167
Range on HMM: 43-179/293.0
YACFAVFDGHGGKEAAVYARDHLWQNIKNQ---DGFFSREpNAVMSAINEAFRVTQEGMWKERSSwpktlsGYPS-TAGSTCSMVIICGNDMYTAHVGDS
. .||||||.|. |. .| ..| ..|... . . ..| . . .. ..|. | | . |. |. . |. ||| .|.. | .|.| .|||
vsyyavfdGhaGsrasefaaeklhkkileklpksdvsake.keikkclvdsfkktdeefLklask......akPvWkdGstatvvlvldnvlyvanlGds
RIVLGKSEPRGLNttnvygvtshkIVTETLTVDHKPSDIEEIERIEEAGGRVQDK
. || . .. | . |.. .||.||.| . || .||. ||| |.|
kavlvrkkeegdk...........iasvvLtkdhtpvkyeerkriqkaGgvvrdg
|
|||||||||
| PPM_PTC7_SpoIIE | 19-258 | 5.2e-26 | 84.9 | In-house | 36-205 (230) | alignment | |||
Range on Protein: 19-258
Range on HMM: 36-205/230.0
CFAVFDGHGGKEaaVYARDHLWQNIKNQDgFFSRE-PNAVMSAINEAF-RVTQEGmwkersswpktlsgyPSTAGSTCSMVIICGND--MYTAHVGDSRI
....||||| . .|. .|.. .... | . | |.......|.|. . ... ||. |.|.. ..| ... .|.|..|||..
vvgdvdGhGgra..alamgllrtalrela.faglekpeeilrrlnlalaadlede...............psssgaTavvalidpstgklyvanaGdspp
VLGKSEPRglnttnvygvtshkivtetltvdhkpsdieEIERIeEAGGRVQdK-AGVQRVVWSrpkldhtgpitrnteltdipfLAVARSLGDLWSYNfr
.| ..... |.||| .||| . .. .||... |||... |||. .
llvrddgg..............................ereri.vagglps.lGilpgrvfgv.....................lavslapGdlllly..
sGKYIVSPEPDiMHRVIDPKSERFLILGSDGLWNMVTSEASVQIV
.|..||| . ... ..||||.|||||...... |..|
.tDGvveaepd.tsdgelfgkdeflilasdglwdvlspqelvdlv
|
|||||||||
| subfamily_Choan-PPM1K-like_pd | Subfamily Choan-PPM1K-like | 19-167 | 4.4e-14 | 45.7 | In-house | 21-151 (292) | alignment | ||
Range on Protein: 19-167
Range on HMM: 21-151/292.0
CF--AVFDGHG--GKEAAVYARDHLWQNIKNQDGFFSREPNAVMSAIneafrVTQEGMWKErSSWPKTLSGypsTAGSTCSMViICGNDMYTAHVGDSRI
| ||.|||| |.. | .| |.| ... . ..|.. | . ... . . .|. |. .|..| . .. |.|||||
tflaavldGhGvnGdkvaqlaedtlevelleltrqlqelsealllri.....ldiaakldk.ltidaresa...ttavvcarv.rddralilanvGdsra
VLGKSeprglnttnvYGVTSHKivTETLTVDHKPSDIEEIERIEEAGGRVQDK
.||. | . .. |. ||||.| .| .|| |||||.
llgrc..........lggsdye..liPlsrdhkPedPderarilraGGrvept
|
|||||||||
| subfamily_PDP_pd | Subfamily PDP | 58-159 | 9.7e-08 | 24.5 | In-house | 116-209 (398) | alignment | ||
Range on Protein: 58-159
Range on HMM: 116-209/398.0
MSAINEAFRVTQEGMWKERS-SWPKTL---SGYPSTAGSTCSMVIICGNDMYTAHVGDSRIVLGKSEPRGlnttnvygvtshKIVTETLTVDHKPSDIEE
.|...|| . . .| . ... . ....|... .. | |.... | .||.| |||..|..| . . .|. |. . ||
kealkkaFlklDkdistealkklkekslreallvalsGacallaliegtelhvAntGDcravlgvqeeeg............sweavkLskdqtadneeE
IERIEE
.|||..
veRikk
|
|||||||||
| subfamily_PPM1G_pd | Subfamily PPM1G | 89-167 | 1.3e-12 | 40.5 | In-house | 295-356 (473) | alignment | ||
Range on Protein: 89-167
Range on HMM: 295-356/473.0
TAGSTCSMVIICGNDMYTAHVGDSRIVLGKSeprglnttnvygvtshkIVTETLTVDHKPSDIEEIERIEEAGGRVQDK
.|.| .... ..... | .|||| || .. . | .|||| | .| ||||.|||.|.
dsGttAvvaLlkekklivAnaGDsRcvlsrn.................GkAldlslDHkPeDevEleRiekAGGkvded
|
|||||||||
| subfamily_ILKAP_pd | Subfamily ILKAP | 179-303 | 1.3e-07 | 24.1 | In-house | 168-290 (293) | alignment | ||
Range on Protein: 179-303
Range on HMM: 168-290/293.0
KLDHTGPITRNTELTDIpfLAVARSLGDLwsyNFRSGKyiVSPEPDIMHRVIDPKsERFLILGSDGLWNMVTSEASVQIVEK----YDKTRILQGEQSSE
... .| |. .. . | |.||.|| .|.. |. ||... ... ..|..| ||||. .. .. |. . | .. | ...|.. .
riqkaGgvvrdgrvlGv..levsrsiGdg...rfkrlG..vistPdvkkceLten.dlfvvlaCdGLwkvfsadevvkfilkvledeeddrkikeeekks
T--VSHQLVKRGMDLWNYHLLRADNISVICV
. | .... . . .||..|. |
keevrfevacnrlaseavkrgssdnvtvllv
|
|||||||||
| subfamily_Dicty-PPM-1_pd | Subfamily Dicty-PPM-1 | 186-303 | 8e-09 | 27.8 | In-house | 169-274 (276) | alignment | ||
Range on Protein: 186-303
Range on HMM: 169-274/276.0
ITRNTELTDIPFLAVARSLGDLWSYNFRSGkyiVSPEPDIMHRVIDPKSERFLILGSDGLWNMVTSEASVQIVEK-YDKtrilqgEQSSETVSHQLVKRG
|| . | | |||.|.||| . . | .. || . |.. ..|||. |||||.... . ....|. ||. ..... .. |..
itlsdnqtrinGlavsralGdhfikelniG...lisepyvsnrilltpfdkflivasdGlwdvisGkdaiekvkslydq......qatedkmasslleta
MDlwnyHLLRADNISVICV
.. . ||.||| |
iq....sikakdnvsvivv
|
|||||||||
| subfamily_KAPP-like_pd | Subfamily KAPP-like | 186-303 | 8e-09 | 27.9 | In-house | 159-264 (266) | alignment | ||
Range on Protein: 186-303
Range on HMM: 159-264/266.0
ITRNTELTDIPFLAVARSLGDLWSYNFRSGkyiVSPEPDIMHRVIDPKSERFLILGSDGLWNMVTSEASVQIVEK-YDKtrilqgEQSSETVSHQLVKRG
|| . | | |||.|.||| . . | .. || . |.. ..|||. |||||.... . ....|. ||. ..... .. |..
itlsdnqtrinGlavsralGdhfikelniG...lisepyvsnrilltpfdkflivasdGlwdvisGkdaiekvkslydq......qatedkmasslleta
MDlwnyHLLRADNISVICV
.. . ||.||| |
iq....sikakdnvsvivv
|
|||||||||
| subfamily_PPM1L_pd | Subfamily PPM1L | 197-260 | 1.8e-09 | 30.3 | In-house | 175-235 (269) | alignment | ||
Range on Protein: 197-260
Range on HMM: 175-235/269.0
FLAVARSLGDlwsYNFRSGKyIVSPEPDIMHRVIDPKSERFLILGSDGLWNMVTSEASVQIVE-K
||..|.||| | .. . .| ..|||. .| . .|||| |||||. . | .|. . .
vlatsralGd...yplkdkn.lviadpdiltfdlddhkpeflilasdGlwdtfsneeavrfiker
|
|||||||||
| subfamily_PPM1E_pd | Subfamily PPM1E | 198-306 | 2.3e-12 | 39.7 | In-house | 171-263 (265) | alignment | ||
Range on Protein: 198-306
Range on HMM: 171-263/265.0
LAVARSLGDlwsynfRSGKYIVSPEPDIMHRVIDpKSERFLILGSDGLWNMVTSEASVQIVEKYdktrILQGEQSSETVSHQLVKRGMDLwnyhlLRADN
|.|.|..|| .. | || |.|... .| .|| .|||..||||..|. | |..||.. . .|......|...||. . .||
LsvsRaiGD......vklkpyvsgeadvaeveld.gseeylilacDGlwDvvneeevvklveef....ladgaedlsevakllveaakea.....gssDn
ISVICVFFE
|.|. ||..
itvvvvfld
|
|||||||||
| subfamily_PPM1G_pd | Subfamily PPM1G | 200-280 | 6.3e-07 | 21.7 | In-house | 365-444 (473) | alignment | ||
Range on Protein: 200-280
Range on HMM: 365-444/473.0
VARSLGDlWSYN----FRSGKYIVSPEPDIMHRVIDPKSErFLILGSDGLWNMVTSEASVQIVekydKTRILQGEQS-SETVSHQL
..| ||| ..| ..| ||| ... .. | ||.| .||.||...|. |. | .... .||.| ... ..|
lsRAlGD.haYkkneeLplkeqmisAlPDikvltlteede.FlvlAcDGiWnvmesqevvdfv....raklkkgeesvlseiveeL
|
|||||||||
| subfamily_PDP_pd | Subfamily PDP | 219-274 | 3.2e-10 | 32.7 | In-house | 270-324 (398) | alignment | ||
Range on Protein: 219-274
Range on HMM: 270-324/398.0
VSPEPDIMHRVIDPKsERFLILGSDGLWNMVTSEASVQIVEKYDKTRILQGEQSSE
.. ||..... . .. ..||.|..||||.....|. |..|... . . . . ..|
ltaePevtshklren.dkFLvlatDGLwdllsneevvslVgehlakkkekepvkve
|
|||||||||
| PPM_PTC7_motif | 239-261 | 1.8e-06 | 21.4 | In-house | 1-23 (51) | alignment | |||
Range on Protein: 239-261
Range on HMM: 1-23/51.0
ILGSDGLWNMVTSEASVQIVEKY
||.|||||...... |..| .
iLAsDGLWDvlsdqeavdlvrdq
|
|||||||||