Gene PPM1L in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1L
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP192_AA protein Get Run
SpurP192_AA_107-366 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1L_pd Subfamily PPM1L 104-367 5.8e-149 487.6 In-house 2-268 (269) alignment 
Range on Protein: 104-367
Range on HMM: 2-268/269.0
LREDNVAVYSIQGRRPGMEDRFDYATGEKDGVTEKFCGIYDGHGGEFAAEFTEKLLSQAVLARL---ATAKRRQLPVNHSQILVEEILAVDEKFLTVAKS
 ....|||||..|||| |||||......|....|.|....|||||||||||....|..|....|   ...|....|.|.|..|..|||.||||.|..||.
ekkqqvavysvlGrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakr

NEDMAGSTALVALITESDVIVANVGDSRGVMCDGSGKTVPLSYDHKPHHPQERKRIKKAGGFIAFNGVWRVAGILATSRAIGDYPLKDHKFVVADPDILS
.||.||.|||.||..|||.|||||||||||..| .||..|||.||||....||||||||||||||.|||||||.||||||.|||||||...|.||||||.
aediaGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdknlviadpdilt

FDLDEHNPQFLILATDGLWDTFTNEEAVQYIKERLGEPHFGAKSLVLQAFYRGSMDNITVMVVNLSR
||||.|.|.|||||.|||||||.|||||..|||||.||.||||||||..|.|||.|||||.||.|..
fdlddhkpeflilasdGlwdtfsneeavrfikerlkepdfGakslvlesfkrGsvdnitvlvvklkn
subfamily_PPM1A_pd Subfamily PPM1A 104-365 2.6e-66 216.8 In-house 9-280 (282) alignment 
Range on Protein: 104-365
Range on HMM: 9-280/282.0
LREDNVAVYSIQGRRPGMEDRFDYATGEKDGVTEKFCGIYDGHGGEFAAEFTEKLLSQAVLAR--LA-TAKRRQLPVNHSQILVEEILAVDEKFLTVAKS
...  ..| | ||.|  |||......  .   . .|  ..|||.|. .|....| | ...| .  |  .|....   .... | ...||.||.  .  ..
gnglrygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairelstd

NE--DMAGSTALVALITESDVIVANVGDSRGVMCDGsGKTVPLSYDHKPHHPQERKRIKKAGGFIAfngVWRVAGILATSRAIGDYPLKD-------HKF
..  | .||||...|..|. .|.||.||||.|.| . ||.. |..||||..|.|.|||..|||..    | || | || |||.||| .|.       .. 
lktadksGsTavtvlvsekhliianlGDsRavlcrn.gkaaflteDHkpsrpkEkkRieqAGGsvv...vsRvnGaLAvsRalGDyeykeeeekkaeeql

VVADPDILSFDLDEHNPqFLILATDGLWDTFTNEEAVQYIKERLG---EPHFGAKSLVLQAFYRGSMDNITVMVVNL
|.|.|.. |.. .|..  ||.|| ||.||. ..||.|.....||.   |..  ||.|| .|. .|| ||..|.|| .
vsaepevtsierseedd.flvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsrDNlsvlvvlf
subfamily_PPM1G_pd Subfamily PPM1G 106-166 3.7e-07 22.5 In-house 18-76 (473) alignment 
Range on Protein: 106-166
Range on HMM: 18-76/473.0
EDNVAVYSIQGRRPGMEDRFDYATGEKDgvTEKFCGIYDGHGGEFAAEFTEKLLSQAVLAR
| .... . || | ..||     |  ..  . .. ..||||||.  |... | | . . |.
elsygasamqGwrvsqEDahncitdlde..dtslfavyDGHGGkevakyvakklpdllkaq
subfamily_PPM1K_pd Subfamily PPM1K 107-368 4.8e-46 150.0 In-house 4-261 (263) alignment 
Range on Protein: 107-368
Range on HMM: 4-261/263.0
DNVAVYSIQGRRPGMEDRFDYATGEKDGVtekFCGIYDGHGGEFAAEFTEKLLSQAVLARLatAKRRQLpvnhSQILVEEILAVDEKFL-----TVAKSN
..| . |..|.|   |||.. .  ... .   . ...|||.|  ||.|. . | . .   |   | ..|     ..|..  . .|.|.      .||...
esvGkdsliGkraenedriklkeldpell...yvavfdGhaGsaaadfvhdklekilkrll..ekekdl....eivlknafeeldkklkrylefsvaeae

EDMAGSTALVALITE-SDVIVANVGDSRGVMCDgSGKTVPLSYDHKPHHPQERKRIKKAGGFIAFN--GVWRVAGILATSRAIGDYPLKDHkFVVADPDI
.  .|.|| |.|. .  ....|..|||| ..|   ||.  |. ||.|.. .|..|||.|||....|  |  .| | || .|..||  || .  |.|.|. 
llssGttatvsllrdGtelvlaslGdsrailcr.nGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkry.GviatPet

LSFDLDEHNPQFLILATDGLWDTFTNEEAVQYIKeRLGEPHFGAKSLVLQAFYRGSMDNITVMVVNLSRH
 |...|  .  ||.| |||. .  ...|  ....    .|.  |..|. ||.  || || |..|| |   
kslkvdhaadsflvlitdgisfvvnsqelcdlvr.lchdpeeaahalteqalqygsednatavvvplgaw
0034914 PP2C-like 108-366 8.4e-69 224.5 In-house 22-291 (295) alignment 
Range on Protein: 108-366
Range on HMM: 22-291/295.0
NVAVYSIQGRRPGMEDRFDYATGEKD-GVTEKFCGIYDGHGGEFAAEFTEKLLSQAVLARLATA--KRRQLPVNHSQILVEEILAVDEKFLTVAKS--NE
.|.|.|.||||. .||.. . ..         ..|..|||||  |||.  .|| ...|  |      .   . .  ..|.. .||.||..|. | .  . 
rvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellelallrpel

DMAGSTALVALITESDVIVANVGDSRGVMCdGSGKTVPLSYDHKPHHPQERKRIKKAGGFIAFngvWRVAGILATSRAIGDYPLKDH-------KFVVAD
.. |.||.||||... ..|||||||| |..  .|. |.|..|||| .. ||.||..|||.. .   .|| |.|| .||.||..|| .        .|.| 
agsGtTavvalirgnklyvanvGDSravll.rngelvqltvdhkpvnelererilsaggavsh...grvngvlavtRalGdfdlklllslllleplvsae

PDILSFDLDEHNPQFLILATDGLWDTFTNEEAVQYIKER---LGEPHFGAKSLVLQAFYRGSMDNITVMVVNLS
||. ...|. .. .||.||.|||||...|||.|......     ...  |. || .|. |||.|||||.|| |.
PdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTvvvvrln
subfamily_PPM1E_pd Subfamily PPM1E 108-365 6.2e-59 192.3 In-house 5-262 (265) alignment 
Range on Protein: 108-365
Range on HMM: 5-262/265.0
NVAVYSIQGRRPGMEDRFDYAT------GEKDGVTEKFCGIYDGHGGEFAAEFTEKLLSQavlarlATAKRRQLPVNHSQILVEEILAVDEKFLTVAKSN
.| .......|  ||||.          . ||  .. | ...|||||  ||... . | .       .... .|. .  . | | . ..||.||. |...
evsiaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhe......llvrqeklkedpaealkeafkltDerflqkaere

EDMAGSTALVALITESDVIVANVGDSRGVMCDgSGKTVPLSYDHKPHHPQERKRIKKAGGFIAFNGVWRVAGILATSRAIGDYPLKdhKFVVADPDILSF
.  .|||| |.||... . || .|||.....   |..| |   ||| ...|.|||..|||.. . |.||| |.|. ||||||. ||  ..|....|. ..
klksGstavvvliekdqlyvaWlGDsqallvr.kgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklk..pyvsgeadvaev

DLDEHNpQFLILATDGLWDTFTNEEAVQYIKERLGEPH----FGAKSLVLQAFYRGSMDNITVMVVNL
.||... ..||||.|||||....||.|. ..| | ...      ||.|| .|  .|| |||||.|| |
eldgse.eylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvvfl
0049733 PP2C-like 108-365 3.8e-56 182.9 In-house 4-233 (235) alignment 
Range on Protein: 108-365
Range on HMM: 4-233/235.0
NVAVYSIQGR-RPGMEDRFDYatgekdgvTEKFCGIYDGHGGEFAAEFTEKLLSQAVLARLATakrrQLPVNHSQILVEEILAVDEKFLTVAKSN--EDM
.|...|..|| |. .||.. .           .....|||||  |.|.  .|| ...|. |..    .|. .  ..|.. .||..| .|  |...   ..
svgaasdigrvrkvneDavlv........glllfavaDGhgghaagevasellvetllellle....lllldleealrkaflaaneallelalaspelag

AGSTALVALITESDVIVANVGDSRGVMCDgSGKTVPLSYDHKPHHPQERKRIKKAGGFIafngvwRVAGILATSRAIGDYPLKdhkfvvadPDILSFDLD
 |.||.|||.... ..|||||||| .... .|| |.|..||.| ...||.||..|||..      || |.|| .||.||..||        ||. ...|.
mgtTavvalldggklyvanvGDsrayllr.dgklvqltedhspvnelerqriitaggav......rvpgrlaltralGdlllk........pdvtvlele

EHNpqFLILATDGLWDTFTNEEAVQYIKErlGEPHFGAKSLVLQAFYRGSMDNITVMVVNL
...  ||.||.||||| ...||.|.....   ...  |. || .|. ||..|||||.|| |
pgd..flllasDGlwdvlsdeeivdllrs..ldleeaaerlvelalarggrDNiTvvvvrl
subfamily_PPM1G2_pd Subfamily PPM1G2 108-364 4.8e-56 182.8 In-house 20-285 (287) alignment 
Range on Protein: 108-364
Range on HMM: 20-285/287.0
NVAVYSIQGRRPGMEDRFDY---ATGEKDGVTEKFCGIYDGHGGEFAAEFTEKLLSQAVLArlataKRRQLPVNHSQILVEEILAVDEKFLTVAKSNEDM
.|.  ..|| |  |||          ..|  .  . ...|||||. .|... | | . . .     |.     . .||| . .|..||..|   | ....
kvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiak.....kksfkegaleqilkdafletDeellkdeklkdes

AGSTALVALITESDVIVANVGDSRGVMCDGSGkTVPLSYDHKPHHPQERKRIKKAGGFIAFNgvwRVAGILATSRAIGDYPLKDHK-------FVVADPD
|||||.|.||.|....|||.|||| |..  .  .  ||.||||.. .|.|||..||||...|   ||.| || |||.||.  |...        | | ||
aGstavvvlikeeklyvanaGDsravlsskgn.vkalsfDhkPqeesekkriiaagGfveln...rvngnLalsralgDfefkknvkkkpeeqivtavPD

ILSFDLDeHNPQFLILATDGLWDTFTNEEAVQYIKERLGEPHF---GAKSLVLQAFYRGSM------DNITVMVVN
.|  .|| ..  ||.|| ||.|| .||.| |....||| . .     ...|. ..  . |       ||.||..| 
vlvkkld.eddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvvivv
subfamily_PPM1D_pd Subfamily PPM1D 109-366 1.7e-33 109.0 In-house 4-308 (309) alignment 
Range on Protein: 109-366
Range on HMM: 4-308/309.0
VAVYSIQGRRPGMEDRFDYATGEKDGV---TEKFCGIYDGHGGEFAAEFTEKLLSQAVLARLA--TAKRRQLP--VNHSQILV-EEILAVDEKFLTVAKS
|.. . || |. |||..  .. |..        | ...|||||. ||.|. . | . .  .    . . ...   .... . . |..  . |..   .. 
vtseadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktksg

NEDMAGSTALVALITESDVIVANVGDSRGVMCDGSG-----KTVPLSYDHKPHHPQERKRIKKAGGFIAFN-GVWRVA-----------------GILAT
.   ||.|| | .|..... ||.||||. |.          .. .|  ||||..|.|..||...|| .| . || ||.                   || 
llstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngptvideiPFLav

SRAIGD---YPLKDHKFVVA-DPDILSFDLDEHNPQFLILATDGLWDTFTNEEAVQYIKERLGEPHF-------GAKSLVLQAFYRGSM-----DNITVM
.|..||   |  | ..|||  .||.  . || .. .|.|||.||||.  | |.||. ...      .        || || .|. | .      ||..|.
aRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklraDnvsvi

VVNLS
|| |.
vvile
PP2C Protein phosphatase 2C 110-358 1.5e-62 204.5 Pfam-A 4-255 (255) alignment 
Range on Protein: 110-358
Range on HMM: 4-255/255.0
AVYSIQGRRPGMEDRFDYAT-GE--KDGVTEKFCGIYDGHGGEFAAEFTEKLLSQAVLARLATAKRRqlpvNHSQILVEEILA-VDEKFLTVAKS-NEDM
 . ..||.|  |||.  .    |  ..  ...| ...|||||. ||..... | . .  .  . . .    . ...| . .||  ||.. . ...  .. 
gaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele....kvekalrksfladtdeelksskantepsk

AGSTALVALITESDVIVANVGDSRGVMCDGSGKTVPLSYDHKPHHPQERKRIKKAGGFIAFngVWRVAGILATSRAIGDYPLKD--HKFVVADPDILSFD
 ||||.||||......|||||||| |.|....  . |..|||| ...||.||..|||..    ..|| | || |||.||. ||.   ..|.|.||. |..
sGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn..ngrvngsLavsRalGdfelkpkeeqlvsaePdvtsvk

LDEHnPQFLILATDGLWDTFTNEEAVQYIKERLGE---PHFGAKSLVLQAFYRGSMDNI
|.|.  .|||||.||||| ....|||. ....| .   |   |. || .|  |||.|||
ltee.defliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PP2C Protein phosphatase 2C 110-358 1.5e-62 204.5 In-house 4-255 (255) alignment 
Range on Protein: 110-358
Range on HMM: 4-255/255.0
AVYSIQGRRPGMEDRFDYAT-GE--KDGVTEKFCGIYDGHGGEFAAEFTEKLLSQAVLARLATAKRRqlpvNHSQILVEEILA-VDEKFLTVAKS-NEDM
 . ..||.|  |||.  .    |  ..  ...| ...|||||. ||..... | . .  .  . . .    . ...| . .||  ||.. . ...  .. 
gaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele....kvekalrksfladtdeelksskantepsk

AGSTALVALITESDVIVANVGDSRGVMCDGSGKTVPLSYDHKPHHPQERKRIKKAGGFIAFngVWRVAGILATSRAIGDYPLKD--HKFVVADPDILSFD
 ||||.||||......|||||||| |.|....  . |..|||| ...||.||..|||..    ..|| | || |||.||. ||.   ..|.|.||. |..
sGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn..ngrvngsLavsRalGdfelkpkeeqlvsaePdvtsvk

LDEHnPQFLILATDGLWDTFTNEEAVQYIKERLGE---PHFGAKSLVLQAFYRGSMDNI
|.|.  .|||||.||||| ....|||. ....| .   |   |. || .|  |||.|||
ltee.defliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PPM_PTC7 110-358 1.8e-61 200.9 In-house 4-259 (259) alignment 
Range on Protein: 110-358
Range on HMM: 4-259/259.0
AVYSIQGRRPGMEDRFDYATGEK---DGVTEKFCGIYDGHGGEFAAEFTEKLLSqavlaR-----LATAKRRqlpvNHSQILVEEILA--VDEKFLTVAK
 . ..||.|  |||.  .. .     .   ..| ...|||||  ||..... |                . .    . ...| . .||   ||.. . ..
gasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehle.....eilkerksfeele....klekalrksflaldtdeelkssea

SN-EDMAGSTALVALITESDVIVANVGDSRGVMCDGSGKTVPLSYDHKPHHPQERKRIKKAGGFIAFNGVWRVAGILATSRAIGDYPLKD----HKFVVA
.. ..  ||||.|||||.|...|||||||| |.|.. .  ..|..|||| ...||.||..|||..   |..|| | || |||.||. ||.     . |.|
ntepstsGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpketeeqlvsa

DPDILSFDLDEHnPQFLILATDGLWDTFTNEEAVQYIKERLGE--PHFGAKSLVLQAFYRGSMDNI
.||| | ..||.  .|||||.||||| ....|||. ....| .  |   |. ||  |  |||.|||
ePdisstkidee.defliLasdGlwdvvsdqeavdlvrselskkdpmeaaeklvdeaiargsedni
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 110-366 5.6e-55 179.3 In-house 9-254 (255) alignment 
Range on Protein: 110-366
Range on HMM: 9-254/255.0
AVYSIQGRRPGMEDRFDYATGEKDGVTEKFCGIYDGHGGEFAAEFTEKLLSQaVLARLATAKRRqlpvNHSQILVEEILAVDEKFltvaKSNEDMAGSTA
.   . |||| |||..      .|.  |..  ..|||||. ||.|. . | . .|| |  ...     |  ..| .   ... ..    .    . |.||
gfsdmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelyk.ilaelldlnna....nPvkslkkaykeistqi....serpkfiGtta

LVALITESDVIVANVGDSRGVMCDGSGKTVPLSYDHKPHHPQERKRIKKAGGFIAFN-GVWRVAGILATSRAIGDYPLKdhKFVVADPDIL-SFDLDEhN
 ..||.|  |..||||||| |.|.  | .. ||.|||| ...|.|||...||..  .    || | || |||.||  |.   |||.|||.  |..  . .
asvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsfle..PfvvpdPdlsqsleisk.k

PQFLILATDGLWDTFTNEEAVQYIKErLGEPHFGAKSLVLQAFYRGSMDNITVMVVNLS
 .||||| ||.||  ..||||. . .   .|.  |. |  .|. .|| |||.|.|..||
dkflilacdGiwdlisdeeaveivag.isdpekaaeklrdlayssGstdnisvivikls
PPM_PTC7_SpoIIE 111-343 2.1e-31 102.5 In-house 5-213 (230) alignment 
Range on Protein: 111-343
Range on HMM: 5-213/230.0
VYSIQGRRPGMEDRFDYATGE---KDGVTEKFCGIYDGHGGEFaAEFTEKLLSQAVLARLATAKrrqlpvnhsqilvEEILAVDEKFLTVAKSNEDM---
. ..||.| .|||.  .. .     .| .  . |..|||||   | ... | .    .. |..              .   .. . .| .|.  ||.   
asaaqgarksmedahispansekssggrlalvvgdvdGhGgra.alamgllrtalrelafagle.............kpeeilrrlnlalaadledepss

AGSTALVALITESD--VIVANVGDSRGVMCDGSGKtvplsydhkphhpqERKRIkKAGGFIA---FNGvwRVAGILATSRAIGDYPLKDHKFVV-ADPDi
 |.||.||||. |.  . |||.|||. ......|.              ||.|| .|||..    ..|  ||.| || |.|.||. |..  .|| | || 
sgaTavvalidpstgklyvanaGdsppllvrddgg..............ereri.vagglpslGilpg..rvfgvlavslapGdllllytDGvveaepd.

LSFDLDEHNPQFLILATDGLWDTFTNEEAVQYIKERLGEPhfgaK
 | .... . .|||||.|||||  ...|.|. ....|..|     
tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp....a
PP2Cc_SM00332 112-363 2.4e-63 207.1 In-house 15-274 (274) alignment 
Range on Protein: 112-363
Range on HMM: 15-274/274.0
YSIQGRRPGMEDRFDYATGEKDGVTEKFCGIYDGHGGEFAAEFTEKLLSQAVLARLATAKRRQlPVNHSQILVEEILAVDEKFLTVAKSNED---MAGST
 | ||.|  |||..   .  .      |.|..|||||. .|.|. | | .|.  .| . |. .   .  ..| . .|..||..|. ..|.|.    .|||
ssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdel.eddveealkkaflstdeeileeeqskelenalsGst

ALVALITESDVIVANVGDSRGVMCDGSGkTVPLSYDHKPHHPQERKRIKKAGGFIAFNgvwRVAGILATSRAIGDYPLK-----DHKFVVADPDILSFDL
|.|||... |..|||||||| |.| ..   |.||.||||....||||||||||.....   || | || |||.||. ||       ....|.||.   .|
avvallkkedlyvanvGDSravlcrngk.avqlsvdhkpedederkRikkaggvvekg...rvngglavsrafGdhflkknkklkepyitaepdvkvvtl

DEHNpQFLILATDGLWDTFTNEEAVQYIKERL-----GEPHFGAKSLVLQAFYR-GSMDNITVMVV
.... .|||||.||||| ..|.|.|......|      .|.  |. |. .|  | || |||||.||
tsed.eflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv
PP2C_SIG_SM00331 112-364 8.3e-17 54.5 In-house 9-216 (217) alignment 
Range on Protein: 112-364
Range on HMM: 9-216/217.0
YSIQGRRPGmEDRFDYATGEKDgvtEKFCGIYDGHG-GEFAAEFTEKLLSQAVLARLATakrrqlpVNHSQILVEEILAVDEKfltvakSNEDMAGSTAL
|. .... . .| .|. . ...   . .. . ||.| |  ||.....|..       ..        . ||.| . . |..|.      ..|.  . |.|
yyeeatqvs.GDyydvvklneg...rlllvvaDgmGkGlaAaaassqlrtalrellseg.......eelsqalkrlnraiyee......keekgmfaTll

VALI--TESDVIVANVGDSRGVMCDGSGKTVPLSYdhkphhpqerkrikkaggfiafngvwrvagilATSRAIGDYPLKDhkfvvadPDILSFDLDEhnP
.||.  ... . .||.|||| .. . .. . .|.                                  .....|  |  .       .|| ...|..   
lalydfssgklsyanaGdsrpyllrdgklveilkd................................vegaplGlepevs.......vdirelelek..g

QFLILATDGLWDT-----FTNEEAVQYIKERLGEPHFGAKS---LVLQAFYRGS--MDNITVMVVN
 .|.|.||||..      | .|.  . ... .....   ..     | .. .||   |.|||.|| 
dllllytDGltearsekgfaeerleeiledlvdseaqelaqkiveellelakgsngeDdiTvvvvk
subfamily_PP2D1_pd Subfamily PP2D1 121-182 1.1e-06 20.6 In-house 17-79 (492) alignment 
Range on Protein: 121-182
Range on HMM: 17-79/492.0
MEDRFDYATGEKDGVTEKFCGIYDGHGGEFAAEFTEKLLSQAVLARLATA-KRRQLPVNHSQI
|||..       . | . | |||||. | .||| . | | . .| .|.   .| .| ..  .|
meDkrtlqdyfgndvnscFfgiyDGynGataAeiaakelhevlleelekvdervslttavnli
PP2C_2 Protein phosphatase 2C 135-334 5.9e-11 35.1 Pfam-A 24-194 (212) alignment 
Range on Protein: 135-334
Range on HMM: 24-194/212.0
VteKFCGIYDGHGGEFAAEFTEKLLSQAVLARLATAKRRQLPVNHSQILVEEILAVDEKF-----LTVAKSNEDMAGSTALVALITESDVIVANVGDSRG
.  ... . ||.|    ..   .|. .|.. .|..   .. . .....|..   .....         .... .  ..| |.|.||.  ......||.. 
g..wllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavitpgeivffqiGDgai

VMCDGSGKTVPLSYDHKPHHPQERKRIKKAGGFIAFngvwrvagilatsraigdyplkdhkfvvadpDILSFDldEHNPQFLILATDGLWDTFTNEEAV-
|. |..|.. .|. ...  .  |  .....  .  .                               .| ...   . .. |.| |||..| ...||.. 
vvrdrdgevqllgepdsgeyanettfltsedaeeel...............................rirrlk..lepgdalllmTDGvsdslrkeepfr

QYIKER
....|.
ellael
PP2C_2 Protein phosphatase 2C 135-334 5.9e-11 35.1 In-house 24-194 (212) alignment 
Range on Protein: 135-334
Range on HMM: 24-194/212.0
VteKFCGIYDGHGGEFAAEFTEKLLSQAVLARLATAKRRQLPVNHSQILVEEILAVDEKF-----LTVAKSNEDMAGSTALVALITESDVIVANVGDSRG
.  ... . ||.|    ..   .|. .|.. .|..   .. . .....|..   .....         .... .  ..| |.|.||.  ......||.. 
g..wllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavitpgeivffqiGDgai

VMCDGSGKTVPLSYDHKPHHPQERKRIKKAGGFIAFngvwrvagilatsraigdyplkdhkfvvadpDILSFDldEHNPQFLILATDGLWDTFTNEEAV-
|. |..|.. .|. ...  .  |  .....  .  .                               .| ...   . .. |.| |||..| ...||.. 
vvrdrdgevqllgepdsgeyanettfltsedaeeel...............................rirrlk..lepgdalllmTDGvsdslrkeepfr

QYIKER
....|.
ellael
subfamily_ILKAP_pd Subfamily ILKAP 138-337 2.2e-44 144.7 In-house 44-245 (293) alignment 
Range on Protein: 138-337
Range on HMM: 44-245/293.0
KFCGIYDGHGGEFAAEFTEKLLSQAVLARLATAKRRQLPVNHSQILVEEILAVDEKFLTVAKSNEDM--AGSTALVALITESDVIVANVGDSRGVMCDGS
 . ...|||.|. |.||. . | . .|..|.  .  .   .  . ||.   ..||.||. |.... .   |||| | |. .  . |||.|||. |..  .
syyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefLklaskakPvWkdGstatvvlvldnvlyvanlGdskavlvrkk

--GK---TVPLSYDHKPHHPQERKRIKKAGGFIAFNgvwRVAGILATSRAIGDYPLKDHkFVVADPDILSFDLDEhNPQFLILATDGLWDTFTNEEAVQY
  |.   .|.|. ||.| . .|||||.||||..  .   || |.|  ||.|||   |    |.. ||.   .|.| | .|..|| ||||..|...|.|..
eegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdg...rvlGvlevsrsiGdgrfkrl.GvistPdvkkceLte.ndlfvvlaCdGLwkvfsadevvkf

IKERLGE
| . |..
ilkvled
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 139-298 5.8e-24 78.1 In-house 22-196 (292) alignment 
Range on Protein: 139-298
Range on HMM: 22-196/292.0
F-CGIYDGHG--GEFAAEFTEKLLSQAVLARLataKRRQlpvNHSQILVEEILAVDEKFLTVAKSNEDMAGSTALVALITES-DVIVANVGDSRGVMCD-
|   ..||||  |.  |...|. | . .|      .. |   . |. |.  || .  |.  .   .   |....  | . .   .|.||||||| ..   
flaavldGhGvnGdkvaqlaedtlevellelt...rqlq...elsealllrildiaakldkltidaresattavvcarvrddralilanvGdsrallgrc

--GS-GKTVPLSYDHKPHHPQERKRIKKAGGFIA--------FNGVWRV------AGILATSRAIGDYPLKDHkFVVADPDI
  ||  . .||| ||||. |.||.||..|||..         |.|  ||       | || |||.||. |..   |||.|..
lggsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdfhlfea.GvvaePel
subfamily_KAPP-like_pd Subfamily KAPP-like 140-365 1.4e-25 82.8 In-house 37-266 (266) alignment 
Range on Protein: 140-365
Range on HMM: 37-266/266.0
CGIYDGHGGEFAAEFTEKLLSQAVLARLATAKRRQ---LPVNHSQILVEEILAVDEKFltvakSNEDMAGSTALVALITES----DVIVANVGDSRGVMC
 ...||| |  ||. ..||. . .   |  .|. .      . |..| . .  ||.|.     .. .  |.|| .||. ..     . |||||||   ..
favfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafkevdakl.....kdfeyeGatatlalvwsdGqqrylqvanvGdssafls

DGSgKTVPLSYDHKPHHPQERKRIKKAGGFIAfNGVWRVAGIlATSRAIGDYPLKDHKF-VVADPDILSFDLDEHNPQFLILATDGLWDTFTNEEAVQYI
 |  ... ||.||| ..|.|..|||. |  .. ..  |. |. | |||.||. .|.    ....| . .  |     .|||.|.|||||  . ..|.. .
rGn.eslelskdhkakdpeekqrikddGitls.dnqtrinGl.avsralGdhfikelniGlisepyvsnrilltpfdkflivasdGlwdvisGkdaiekv

KE--RLGEPHFGAKSLVLQAFYRG--SMDNITVMVVNL
|     .. .    | .|..  .   . ||..|.||.|
kslydqqatedkmasslletaiqsikakdnvsvivvkl
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 140-365 7.5e-23 73.8 In-house 36-276 (276) alignment 
Range on Protein: 140-365
Range on HMM: 36-276/276.0
CGIYDGHGGEFAAEFTEKLLSQAVLARLAT-----AKRR---QLPVNHSQILVEEILAVDEKFltvakSNEDMAGSTALVALITESD----------VIV
 ...||| |  ||. ..||. . ..  | .     .|.    .   . |..| . .  ||.|.     .. .  |.|| .||. ..           . |
favfdGhaGkGaadaakklfpkelekllksgnysltkqddGGdniydqskllldlfkevdakl.....kdfeyeGatatlalvwsdGeeqqqqqqrylqv

ANVGDSRGVMCDGSgKTVPLSYDHKPHHPQERKRIKKAGGFIAfNGVWRVAGIlATSRAIGDYPLKDHKF-VVADPDILSFDLDEHNPQFLILATDGLWD
||||||   .. |  ... ||.|||   |.|..|||. |  .. ..  |. |. | |||.||. .|.    ....| . .  |     .|||.|.|||||
anvGdssaflsrGn.eslelskdhkatdpeekqrikddGitls.dnqtrinGl.avsralGdhfikelniGlisepyvsnrilltpfdkflivasdGlwd

TFTNEEAVQYIKER--LGEPHFGAKSLVLQAFYRG--SMDNITVMVVNL
  . ..|.. .|     .. .    | .|..  .   . ||..|.||.|
visGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivvkl
subfamily_PDP_pd Subfamily PDP 185-287 3.2e-13 42.5 In-house 132-241 (398) alignment 
Range on Protein: 185-287
Range on HMM: 132-241/398.0
EEILAVDEKFLTVAKSNEDMAGSTALVALITESDVIVANVGDSRGVMCDGSG----KTVPLSYDHKPHHPQERKRIKKAGGFIAFNGVW---RVAGILAT
.|.|.  ..  .  . .  ..|..||.||| . .. |||.||.| |..  ..    ..|.|| |.  . ..| .||||.      . |    |. | |. 
tealkklkekslreallvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirngRlLgeLqP

SRAIGDYPLK
.|| ||. .|
lRAFGdvryK
subfamily_PPM1H_pd Subfamily PPM1H 189-258 1.7e-10 33.2 In-house 146-212 (404) alignment 
Range on Protein: 189-258
Range on HMM: 146-212/404.0
AVDEKFLTVAKSNEDMAGSTALVALITESDVIVANVGDSRGVMCdGSGKTVPLSYDHKPHhpQERKRIKK
 .||.     .. ... | ||||||. .  . ||| |||| ...  .....||| |. |.   ||.|...
emDeqiarereayrikGGCtalvalvllgklYvanaGDsRailv.rkdeiiplsadftPe..teRqRlqe
Subfamily Dicty-PPM1L-like 191-293 1.2e-11 37.0 In-house 201-300 (305) alignment 
Range on Protein: 191-293
Range on HMM: 201-300/305.0
DEKFLTVAKSNEDmAGSTALVALITESDV-IVANVGDSRGVMCDgSGKTVPLSYDHKPHHPQERKRIKKAGGF--IAFNGVWRVAGILATSRAIGDyplk
. ..| . .|  |  . . ||.   .| .  ||. .|...|..   |.   |||.... ...|  |.|. ..     || ..|| ...| .| .||    
vnrllkksrskGd.knlkelviPnndspllvvakanDqflvlat.dGlwevlsyqdvveevkellrdkssqkkiewdfneisrviveeavkrgsgD....

DHKFVV
. ..|.
nitlvi
subfamily_PPM1G_pd Subfamily PPM1G 204-337 8.7e-38 123.5 In-house 295-431 (473) alignment 
Range on Protein: 204-337
Range on HMM: 295-431/473.0
MAGSTALVALITESDVIVANVGDSRGVMCDgSGKTVPLSYDHKPHHPQERKRIKKAGGFIAFNGvwRVAGILATSRAIGDYPLKDH-------KFVVADP
 .|.|| |||. | ..||||.|||| |..  .|| . ||.||||  ..|..||.|||| .  .|  || | |  |||.||.  |         . . | |
dsGttAvvaLlkekklivAnaGDsRcvlsr.nGkAldlslDHkPeDevEleRiekAGGkvdedg..RvnGGLnlsRAlGDhaYkkneeLplkeqmisAlP

DILSFDLDEHNpQFLILATDGLWDTFTNEEAVQYIKERLGE
||    | |.. .||.||.||.|.. . .| |......| .
Dikvltlteed.eFlvlAcDGiWnvmesqevvdfvraklkk
subfamily_TAB1_pd Subfamily TAB1 205-298 2.2e-13 42.7 In-house 129-236 (333) alignment 
Range on Protein: 205-298
Range on HMM: 129-236/333.0
AGSTALVALITESDVIVANVGDSRGVMCD--GSGKTVPLSYDHKPHHPQERKRIKKAGgfIAFNGV--WRVAGILATSRAIGDYPLKDH-----------
 |.||.||||   .. |||||||| ...    | | . || ||.   ..| .|.|. |  .  . .   .. |   . |.|||| .|             
gGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLG..ldieqikrnkrlgskentRsiGdykvkkgykdvdilssak

-KFVVADPDI
 . |.|.|||
gePviaePdi
subfamily_PHLPP_pd Subfamily PHLPP 207-365 3.2e-15 48.7 In-house 87-245 (246) alignment 
Range on Protein: 207-365
Range on HMM: 87-245/246.0
STALVALITES--------DVIVANVGDSRGVMCDGsGKTVPLSYDHKPHHPqERKRIKKAGGFIAFNGvwRVAGILATSRAIGDYPLkdHKFVVADPDI
|.||. || ..         . ||.||    |.. . || ..||  .. ..  | ||||.| ..|  ..  .. |.....| .| . |  . .|. .| .
saallilirhdkvdPaksfsLevAsvGtlqavliRn.gkklrlsksyviekd.elkrikeakaiitedn..kingviestrllGytfl..fPvvlPkphv

LSFDLDEHNpQFLILATDGLWDTFTNEEAVQYIKERlGEPHFGAKSLVLQAFYRGSMDNITVMVVNL
 .  | | .  .||.  . ||...  .|||. ...   .|   || || .|   |  |...|.||.|
revlLteqd.ellivGnkalWevlsideaveavrke.edplvaAkklvdlaqsygaadsvsvlvvrl
subfamily_PP2D1_pd Subfamily PP2D1 210-334 1.6e-25 82.8 In-house 181-305 (492) alignment 
Range on Protein: 210-334
Range on HMM: 181-305/492.0
LVALITESDVIVANVGDSRGVMCDGsGKTVPLSYDHKPHHPQERKRIKKAGGFIAFNG-VWRVAGILATSRAIGDYP-LKDHKFVVADPDILSFDLDEHN
 | |.  . . .||.|. . |.| . ||.. |  .| |. ..||.|..|||. .  .. . .| ||| | | .| |  .| .| |. .| . |  |||..
evhleelgvlyianaGnvqAvLcre.GkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdpkLkksvipePkttsvkldeaa

pQFLILATDGLWDTFTNEEAVQYIKER
 |||.||. |||. ...|| .. .|. 
.qflvlAsnGlWevlseeevlsLvkqt
subfamily_PPM1H_pd Subfamily PPM1H 270-337 1.8e-09 29.9 In-house 276-353 (404) alignment 
Range on Protein: 270-337
Range on HMM: 276-353/404.0
RVAGILATSRAIGDYPLKDHK-------FVVADPDILSFDLDEHN---PQFLILATDGLWDTFTNEEAVQYIKERLGE
|. . ....| .||. || ..       |. . |..  .||.. .    . ||||||||||  .|||. . ..| | .
RllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlsk
Subfamily Dicty-PPM1L-like 290-365 1.3e-08 27.1 In-house 218-303 (305) alignment 
Range on Protein: 290-365
Range on HMM: 218-303/305.0
KFVVADPDILSFDLDEHNPQFLILATDGLWDTFTNEEAVQYIKERLGEPHFGA----------KSLVLQAFYRGSMDNITVMVVNL
..|. ..|   . . . | |||.|||||||. . ... |. .|| | .   .           .  | .|  ||| ||||.... |
elviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneisrviveeavkrgsgDnitlviikl
subfamily_PDP_pd Subfamily PDP 291-335 7.5e-11 34.7 In-house 269-312 (398) alignment 
Range on Protein: 291-335
Range on HMM: 269-312/398.0
FVVADPDILSFDLDEhNPQFLILATDGLWDTFTNEEAVQYIKERL
.. |.|...|  | | | .||.||||||||...|||.|....| |
YltaePevtshklre.ndkFLvlatDGLwdllsneevvslVgehl
PPM_PTC7_SpoIIE_motif 310-364 6.1e-07 23.0 In-house 14-79 (81) alignment 
Range on Protein: 310-364
Range on HMM: 14-79/81.0
FLILATDGLW-------DTFTNEEAVQYIKERlgE---PHFGAKSLVLQAFYRG---SMDNITVMVVN
 |.|.||||.       ..|..||........  |   .   |. || ..  .|   . |.||..|. 
vllLyTDGltEardsdgelfgkeellrladra..egkslqeladklvdevlengsgereDDitllvlr
PPM_PTC7_motif 312-358 9.3e-11 35.1 In-house 1-51 (51) alignment 
Range on Protein: 312-358
Range on HMM: 1-51/51.0
ILATDGLWDTFTNEEAVQYIKERLGE----PHFGAKSLVLQAFYRGSMDNI
|||.||||| ....|||. ....| .    |   |. || .|  ||| |||
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni