Gene PPM1L in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1L
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP192_AA protein Get Run
SpurP192_AA_107-366 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1L_pd Subfamily PPM1L 104-367 5.8e-149 487.6 In-house 2-268 (269) alignment
Range on Protein: 104-367
Range on HMM: 2-268/269.0
LREDNVAVYSIQGRRPGMEDRFDYATGEKDGVTEKFCGIYDGHGGEFAAEFTEKLLSQAVLARL---ATAKRRQLPVNHSQILVEEILAVDEKFLTVAKS
 ....|||||..|||| |||||......|....|.|....|||||||||||....|..|....|   ...|....|.|.|..|..|||.||||.|..||.
ekkqqvavysvlGrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakr

NEDMAGSTALVALITESDVIVANVGDSRGVMCDGSGKTVPLSYDHKPHHPQERKRIKKAGGFIAFNGVWRVAGILATSRAIGDYPLKDHKFVVADPDILS
.||.||.|||.||..|||.|||||||||||..| .||..|||.||||....||||||||||||||.|||||||.||||||.|||||||...|.||||||.
aediaGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdknlviadpdilt

FDLDEHNPQFLILATDGLWDTFTNEEAVQYIKERLGEPHFGAKSLVLQAFYRGSMDNITVMVVNLSR
||||.|.|.|||||.|||||||.|||||..|||||.||.||||||||..|.|||.|||||.||.|..
fdlddhkpeflilasdGlwdtfsneeavrfikerlkepdfGakslvlesfkrGsvdnitvlvvklkn

subfamily_PPM1A_pd Subfamily PPM1A 104-365 2.6e-66 216.8 In-house 9-280 (282) alignment
Range on Protein: 104-365
Range on HMM: 9-280/282.0
LREDNVAVYSIQGRRPGMEDRFDYATGEKDGVTEKFCGIYDGHGGEFAAEFTEKLLSQAVLAR--LA-TAKRRQLPVNHSQILVEEILAVDEKFLTVAKS
...  ..| | ||.|  |||......  .   . .|  ..|||.|. .|....| | ...| .  |  .|....   .... | ...||.||.  .  ..
gnglrygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairelstd

NE--DMAGSTALVALITESDVIVANVGDSRGVMCDGsGKTVPLSYDHKPHHPQERKRIKKAGGFIAfngVWRVAGILATSRAIGDYPLKD-------HKF
..  | .||||...|..|. .|.||.||||.|.| . ||.. |..||||..|.|.|||..|||..    | || | || |||.||| .|.       .. 
lktadksGsTavtvlvsekhliianlGDsRavlcrn.gkaaflteDHkpsrpkEkkRieqAGGsvv...vsRvnGaLAvsRalGDyeykeeeekkaeeql

VVADPDILSFDLDEHNPqFLILATDGLWDTFTNEEAVQYIKERLG---EPHFGAKSLVLQAFYRGSMDNITVMVVNL
|.|.|.. |.. .|..  ||.|| ||.||. ..||.|.....||.   |..  ||.|| .|. .|| ||..|.|| .
vsaepevtsierseedd.flvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsrDNlsvlvvlf

subfamily_PPM1G_pd Subfamily PPM1G 106-166 3.7e-07 22.5 In-house 18-76 (473) alignment
Range on Protein: 106-166
Range on HMM: 18-76/473.0
EDNVAVYSIQGRRPGMEDRFDYATGEKDgvTEKFCGIYDGHGGEFAAEFTEKLLSQAVLAR
| .... . || | ..||     |  ..  . .. ..||||||.  |... | | . . |.
elsygasamqGwrvsqEDahncitdlde..dtslfavyDGHGGkevakyvakklpdllkaq

subfamily_PPM1K_pd Subfamily PPM1K 107-368 4.8e-46 150.0 In-house 4-261 (263) alignment
Range on Protein: 107-368
Range on HMM: 4-261/263.0
DNVAVYSIQGRRPGMEDRFDYATGEKDGVtekFCGIYDGHGGEFAAEFTEKLLSQAVLARLatAKRRQLpvnhSQILVEEILAVDEKFL-----TVAKSN
..| . |..|.|   |||.. .  ... .   . ...|||.|  ||.|. . | . .   |   | ..|     ..|..  . .|.|.      .||...
esvGkdsliGkraenedriklkeldpell...yvavfdGhaGsaaadfvhdklekilkrll..ekekdl....eivlknafeeldkklkrylefsvaeae

EDMAGSTALVALITE-SDVIVANVGDSRGVMCDgSGKTVPLSYDHKPHHPQERKRIKKAGGFIAFN--GVWRVAGILATSRAIGDYPLKDHkFVVADPDI
.  .|.|| |.|. .  ....|..|||| ..|   ||.  |. ||.|.. .|..|||.|||....|  |  .| | || .|..||  || .  |.|.|. 
llssGttatvsllrdGtelvlaslGdsrailcr.nGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkry.GviatPet

LSFDLDEHNPQFLILATDGLWDTFTNEEAVQYIKeRLGEPHFGAKSLVLQAFYRGSMDNITVMVVNLSRH
 |...|  .  ||.| |||. .  ...|  ....    .|.  |..|. ||.  || || |..|| |   
kslkvdhaadsflvlitdgisfvvnsqelcdlvr.lchdpeeaahalteqalqygsednatavvvplgaw

0034914 PP2C-like 108-366 8.4e-69 224.5 In-house 22-291 (295) alignment
Range on Protein: 108-366
Range on HMM: 22-291/295.0
NVAVYSIQGRRPGMEDRFDYATGEKD-GVTEKFCGIYDGHGGEFAAEFTEKLLSQAVLARLATA--KRRQLPVNHSQILVEEILAVDEKFLTVAKS--NE
.|.|.|.||||. .||.. . ..         ..|..|||||  |||.  .|| ...|  |      .   . .  ..|.. .||.||..|. | .  . 
rvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellelallrpel

DMAGSTALVALITESDVIVANVGDSRGVMCdGSGKTVPLSYDHKPHHPQERKRIKKAGGFIAFngvWRVAGILATSRAIGDYPLKDH-------KFVVAD
.. |.||.||||... ..|||||||| |..  .|. |.|..|||| .. ||.||..|||.. .   .|| |.|| .||.||..|| .        .|.| 
agsGtTavvalirgnklyvanvGDSravll.rngelvqltvdhkpvnelererilsaggavsh...grvngvlavtRalGdfdlklllslllleplvsae

PDILSFDLDEHNPQFLILATDGLWDTFTNEEAVQYIKER---LGEPHFGAKSLVLQAFYRGSMDNITVMVVNLS
||. ...|. .. .||.||.|||||...|||.|......     ...  |. || .|. |||.|||||.|| |.
PdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTvvvvrln

subfamily_PPM1E_pd Subfamily PPM1E 108-365 6.2e-59 192.3 In-house 5-262 (265) alignment
Range on Protein: 108-365
Range on HMM: 5-262/265.0
NVAVYSIQGRRPGMEDRFDYAT------GEKDGVTEKFCGIYDGHGGEFAAEFTEKLLSQavlarlATAKRRQLPVNHSQILVEEILAVDEKFLTVAKSN
.| .......|  ||||.          . ||  .. | ...|||||  ||... . | .       .... .|. .  . | | . ..||.||. |...
evsiaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhe......llvrqeklkedpaealkeafkltDerflqkaere

EDMAGSTALVALITESDVIVANVGDSRGVMCDgSGKTVPLSYDHKPHHPQERKRIKKAGGFIAFNGVWRVAGILATSRAIGDYPLKdhKFVVADPDILSF
.  .|||| |.||... . || .|||.....   |..| |   ||| ...|.|||..|||.. . |.||| |.|. ||||||. ||  ..|....|. ..
klksGstavvvliekdqlyvaWlGDsqallvr.kgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklk..pyvsgeadvaev

DLDEHNpQFLILATDGLWDTFTNEEAVQYIKERLGEPH----FGAKSLVLQAFYRGSMDNITVMVVNL
.||... ..||||.|||||....||.|. ..| | ...      ||.|| .|  .|| |||||.|| |
eldgse.eylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvvfl

0049733 PP2C-like 108-365 3.8e-56 182.9 In-house 4-233 (235) alignment
Range on Protein: 108-365
Range on HMM: 4-233/235.0
NVAVYSIQGR-RPGMEDRFDYatgekdgvTEKFCGIYDGHGGEFAAEFTEKLLSQAVLARLATakrrQLPVNHSQILVEEILAVDEKFLTVAKSN--EDM
.|...|..|| |. .||.. .           .....|||||  |.|.  .|| ...|. |..    .|. .  ..|.. .||..| .|  |...   ..
svgaasdigrvrkvneDavlv........glllfavaDGhgghaagevasellvetllellle....lllldleealrkaflaaneallelalaspelag

AGSTALVALITESDVIVANVGDSRGVMCDgSGKTVPLSYDHKPHHPQERKRIKKAGGFIafngvwRVAGILATSRAIGDYPLKdhkfvvadPDILSFDLD
 |.||.|||.... ..|||||||| .... .|| |.|..||.| ...||.||..|||..      || |.|| .||.||..||        ||. ...|.
mgtTavvalldggklyvanvGDsrayllr.dgklvqltedhspvnelerqriitaggav......rvpgrlaltralGdlllk........pdvtvlele

EHNpqFLILATDGLWDTFTNEEAVQYIKErlGEPHFGAKSLVLQAFYRGSMDNITVMVVNL
...  ||.||.||||| ...||.|.....   ...  |. || .|. ||..|||||.|| |
pgd..flllasDGlwdvlsdeeivdllrs..ldleeaaerlvelalarggrDNiTvvvvrl

subfamily_PPM1G2_pd Subfamily PPM1G2 108-364 4.8e-56 182.8 In-house 20-285 (287) alignment
Range on Protein: 108-364
Range on HMM: 20-285/287.0
NVAVYSIQGRRPGMEDRFDY---ATGEKDGVTEKFCGIYDGHGGEFAAEFTEKLLSQAVLArlataKRRQLPVNHSQILVEEILAVDEKFLTVAKSNEDM
.|.  ..|| |  |||          ..|  .  . ...|||||. .|... | | . . .     |.     . .||| . .|..||..|   | ....
kvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiak.....kksfkegaleqilkdafletDeellkdeklkdes

AGSTALVALITESDVIVANVGDSRGVMCDGSGkTVPLSYDHKPHHPQERKRIKKAGGFIAFNgvwRVAGILATSRAIGDYPLKDHK-------FVVADPD
|||||.|.||.|....|||.|||| |..  .  .  ||.||||.. .|.|||..||||...|   ||.| || |||.||.  |...        | | ||
aGstavvvlikeeklyvanaGDsravlsskgn.vkalsfDhkPqeesekkriiaagGfveln...rvngnLalsralgDfefkknvkkkpeeqivtavPD

ILSFDLDeHNPQFLILATDGLWDTFTNEEAVQYIKERLGEPHF---GAKSLVLQAFYRGSM------DNITVMVVN
.|  .|| ..  ||.|| ||.|| .||.| |....||| . .     ...|. ..  . |       ||.||..| 
vlvkkld.eddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvvivv

subfamily_PPM1D_pd Subfamily PPM1D 109-366 1.7e-33 109.0 In-house 4-308 (309) alignment
Range on Protein: 109-366
Range on HMM: 4-308/309.0
VAVYSIQGRRPGMEDRFDYATGEKDGV---TEKFCGIYDGHGGEFAAEFTEKLLSQAVLARLA--TAKRRQLP--VNHSQILV-EEILAVDEKFLTVAKS
|.. . || |. |||..  .. |..        | ...|||||. ||.|. . | . .  .    . . ...   .... . . |..  . |..   .. 
vtseadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktksg

NEDMAGSTALVALITESDVIVANVGDSRGVMCDGSG-----KTVPLSYDHKPHHPQERKRIKKAGGFIAFN-GVWRVA-----------------GILAT
.   ||.|| | .|..... ||.||||. |.          .. .|  ||||..|.|..||...|| .| . || ||.                   || 
llstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngptvideiPFLav

SRAIGD---YPLKDHKFVVA-DPDILSFDLDEHNPQFLILATDGLWDTFTNEEAVQYIKERLGEPHF-------GAKSLVLQAFYRGSM-----DNITVM
.|..||   |  | ..|||  .||.  . || .. .|.|||.||||.  | |.||. ...      .        || || .|. | .      ||..|.
aRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklraDnvsvi

VVNLS
|| |.
vvile

PP2C Protein phosphatase 2C 110-358 1.5e-62 204.5 Pfam-A 4-255 (255) alignment
Range on Protein: 110-358
Range on HMM: 4-255/255.0
AVYSIQGRRPGMEDRFDYAT-GE--KDGVTEKFCGIYDGHGGEFAAEFTEKLLSQAVLARLATAKRRqlpvNHSQILVEEILA-VDEKFLTVAKS-NEDM
 . ..||.|  |||.  .    |  ..  ...| ...|||||. ||..... | . .  .  . . .    . ...| . .||  ||.. . ...  .. 
gaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele....kvekalrksfladtdeelksskantepsk

AGSTALVALITESDVIVANVGDSRGVMCDGSGKTVPLSYDHKPHHPQERKRIKKAGGFIAFngVWRVAGILATSRAIGDYPLKD--HKFVVADPDILSFD
 ||||.||||......|||||||| |.|....  . |..|||| ...||.||..|||..    ..|| | || |||.||. ||.   ..|.|.||. |..
sGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn..ngrvngsLavsRalGdfelkpkeeqlvsaePdvtsvk

LDEHnPQFLILATDGLWDTFTNEEAVQYIKERLGE---PHFGAKSLVLQAFYRGSMDNI
|.|.  .|||||.||||| ....|||. ....| .   |   |. || .|  |||.|||
ltee.defliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni

PP2C Protein phosphatase 2C 110-358 1.5e-62 204.5 In-house 4-255 (255) alignment
Range on Protein: 110-358
Range on HMM: 4-255/255.0
AVYSIQGRRPGMEDRFDYAT-GE--KDGVTEKFCGIYDGHGGEFAAEFTEKLLSQAVLARLATAKRRqlpvNHSQILVEEILA-VDEKFLTVAKS-NEDM
 . ..||.|  |||.  .    |  ..  ...| ...|||||. ||..... | . .  .  . . .    . ...| . .||  ||.. . ...  .. 
gaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele....kvekalrksfladtdeelksskantepsk

AGSTALVALITESDVIVANVGDSRGVMCDGSGKTVPLSYDHKPHHPQERKRIKKAGGFIAFngVWRVAGILATSRAIGDYPLKD--HKFVVADPDILSFD
 ||||.||||......|||||||| |.|....  . |..|||| ...||.||..|||..    ..|| | || |||.||. ||.   ..|.|.||. |..
sGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn..ngrvngsLavsRalGdfelkpkeeqlvsaePdvtsvk

LDEHnPQFLILATDGLWDTFTNEEAVQYIKERLGE---PHFGAKSLVLQAFYRGSMDNI
|.|.  .|||||.||||| ....|||. ....| .   |   |. || .|  |||.|||
ltee.defliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni

PPM_PTC7 110-358 1.8e-61 200.9 In-house 4-259 (259) alignment
Range on Protein: 110-358
Range on HMM: 4-259/259.0
AVYSIQGRRPGMEDRFDYATGEK---DGVTEKFCGIYDGHGGEFAAEFTEKLLSqavlaR-----LATAKRRqlpvNHSQILVEEILA--VDEKFLTVAK
 . ..||.|  |||.  .. .     .   ..| ...|||||  ||..... |                . .    . ...| . .||   ||.. . ..
gasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehle.....eilkerksfeele....klekalrksflaldtdeelkssea

SN-EDMAGSTALVALITESDVIVANVGDSRGVMCDGSGKTVPLSYDHKPHHPQERKRIKKAGGFIAFNGVWRVAGILATSRAIGDYPLKD----HKFVVA
.. ..  ||||.|||||.|...|||||||| |.|.. .  ..|..|||| ...||.||..|||..   |..|| | || |||.||. ||.     . |.|
ntepstsGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpketeeqlvsa

DPDILSFDLDEHnPQFLILATDGLWDTFTNEEAVQYIKERLGE--PHFGAKSLVLQAFYRGSMDNI
.||| | ..||.  .|||||.||||| ....|||. ....| .  |   |. ||  |  |||.|||
ePdisstkidee.defliLasdGlwdvvsdqeavdlvrselskkdpmeaaeklvdeaiargsedni

subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 110-366 5.6e-55 179.3 In-house 9-254 (255) alignment
Range on Protein: 110-366
Range on HMM: 9-254/255.0
AVYSIQGRRPGMEDRFDYATGEKDGVTEKFCGIYDGHGGEFAAEFTEKLLSQaVLARLATAKRRqlpvNHSQILVEEILAVDEKFltvaKSNEDMAGSTA
.   . |||| |||..      .|.  |..  ..|||||. ||.|. . | . .|| |  ...     |  ..| .   ... ..    .    . |.||
gfsdmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelyk.ilaelldlnna....nPvkslkkaykeistqi....serpkfiGtta

LVALITESDVIVANVGDSRGVMCDGSGKTVPLSYDHKPHHPQERKRIKKAGGFIAFN-GVWRVAGILATSRAIGDYPLKdhKFVVADPDIL-SFDLDEhN
 ..||.|  |..||||||| |.|.  | .. ||.|||| ...|.|||...||..  .    || | || |||.||  |.   |||.|||.  |..  . .
asvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsfle..PfvvpdPdlsqsleisk.k

PQFLILATDGLWDTFTNEEAVQYIKErLGEPHFGAKSLVLQAFYRGSMDNITVMVVNLS
 .||||| ||.||  ..||||. . .   .|.  |. |  .|. .|| |||.|.|..||
dkflilacdGiwdlisdeeaveivag.isdpekaaeklrdlayssGstdnisvivikls

PPM_PTC7_SpoIIE 111-343 2.1e-31 102.5 In-house 5-213 (230) alignment
Range on Protein: 111-343
Range on HMM: 5-213/230.0
VYSIQGRRPGMEDRFDYATGE---KDGVTEKFCGIYDGHGGEFaAEFTEKLLSQAVLARLATAKrrqlpvnhsqilvEEILAVDEKFLTVAKSNEDM---
. ..||.| .|||.  .. .     .| .  . |..|||||   | ... | .    .. |..              .   .. . .| .|.  ||.   
asaaqgarksmedahispansekssggrlalvvgdvdGhGgra.alamgllrtalrelafagle.............kpeeilrrlnlalaadledepss

AGSTALVALITESD--VIVANVGDSRGVMCDGSGKtvplsydhkphhpqERKRIkKAGGFIA---FNGvwRVAGILATSRAIGDYPLKDHKFVV-ADPDi
 |.||.||||. |.  . |||.|||. ......|.              ||.|| .|||..    ..|  ||.| || |.|.||. |..  .|| | || 
sgaTavvalidpstgklyvanaGdsppllvrddgg..............ereri.vagglpslGilpg..rvfgvlavslapGdllllytDGvveaepd.

LSFDLDEHNPQFLILATDGLWDTFTNEEAVQYIKERLGEPhfgaK
 | .... . .|||||.|||||  ...|.|. ....|..|     
tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp....a

PP2Cc_SM00332 112-363 2.4e-63 207.1 In-house 15-274 (274) alignment
Range on Protein: 112-363
Range on HMM: 15-274/274.0
YSIQGRRPGMEDRFDYATGEKDGVTEKFCGIYDGHGGEFAAEFTEKLLSQAVLARLATAKRRQlPVNHSQILVEEILAVDEKFLTVAKSNED---MAGST
 | ||.|  |||..   .  .      |.|..|||||. .|.|. | | .|.  .| . |. .   .  ..| . .|..||..|. ..|.|.    .|||
ssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdel.eddveealkkaflstdeeileeeqskelenalsGst

ALVALITESDVIVANVGDSRGVMCDGSGkTVPLSYDHKPHHPQERKRIKKAGGFIAFNgvwRVAGILATSRAIGDYPLK-----DHKFVVADPDILSFDL
|.|||... |..|||||||| |.| ..   |.||.||||....||||||||||.....   || | || |||.||. ||       ....|.||.   .|
avvallkkedlyvanvGDSravlcrngk.avqlsvdhkpedederkRikkaggvvekg...rvngglavsrafGdhflkknkklkepyitaepdvkvvtl

DEHNpQFLILATDGLWDTFTNEEAVQYIKERL-----GEPHFGAKSLVLQAFYR-GSMDNITVMVV
.... .|||||.||||| ..|.|.|......|      .|.  |. |. .|  | || |||||.||
tsed.eflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv

PP2C_SIG_SM00331 112-364 8.3e-17 54.5 In-house 9-216 (217) alignment
Range on Protein: 112-364
Range on HMM: 9-216/217.0
YSIQGRRPGmEDRFDYATGEKDgvtEKFCGIYDGHG-GEFAAEFTEKLLSQAVLARLATakrrqlpVNHSQILVEEILAVDEKfltvakSNEDMAGSTAL
|. .... . .| .|. . ...   . .. . ||.| |  ||.....|..       ..        . ||.| . . |..|.      ..|.  . |.|
yyeeatqvs.GDyydvvklneg...rlllvvaDgmGkGlaAaaassqlrtalrellseg.......eelsqalkrlnraiyee......keekgmfaTll

VALI--TESDVIVANVGDSRGVMCDGSGKTVPLSYdhkphhpqerkrikkaggfiafngvwrvagilATSRAIGDYPLKDhkfvvadPDILSFDLDEhnP
.||.  ... . .||.|||| .. . .. . .|.                                  .....|  |  .       .|| ...|..   
lalydfssgklsyanaGdsrpyllrdgklveilkd................................vegaplGlepevs.......vdirelelek..g

QFLILATDGLWDT-----FTNEEAVQYIKERLGEPHFGAKS---LVLQAFYRGS--MDNITVMVVN
 .|.|.||||..      | .|.  . ... .....   ..     | .. .||   |.|||.|| 
dllllytDGltearsekgfaeerleeiledlvdseaqelaqkiveellelakgsngeDdiTvvvvk

subfamily_PP2D1_pd Subfamily PP2D1 121-182 1.1e-06 20.6 In-house 17-79 (492) alignment
Range on Protein: 121-182
Range on HMM: 17-79/492.0
MEDRFDYATGEKDGVTEKFCGIYDGHGGEFAAEFTEKLLSQAVLARLATA-KRRQLPVNHSQI
|||..       . | . | |||||. | .||| . | | . .| .|.   .| .| ..  .|
meDkrtlqdyfgndvnscFfgiyDGynGataAeiaakelhevlleelekvdervslttavnli

PP2C_2 Protein phosphatase 2C 135-334 5.9e-11 35.1 Pfam-A 24-194 (212) alignment
Range on Protein: 135-334
Range on HMM: 24-194/212.0
VteKFCGIYDGHGGEFAAEFTEKLLSQAVLARLATAKRRQLPVNHSQILVEEILAVDEKF-----LTVAKSNEDMAGSTALVALITESDVIVANVGDSRG
.  ... . ||.|    ..   .|. .|.. .|..   .. . .....|..   .....         .... .  ..| |.|.||.  ......||.. 
g..wllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavitpgeivffqiGDgai

VMCDGSGKTVPLSYDHKPHHPQERKRIKKAGGFIAFngvwrvagilatsraigdyplkdhkfvvadpDILSFDldEHNPQFLILATDGLWDTFTNEEAV-
|. |..|.. .|. ...  .  |  .....  .  .                               .| ...   . .. |.| |||..| ...||.. 
vvrdrdgevqllgepdsgeyanettfltsedaeeel...............................rirrlk..lepgdalllmTDGvsdslrkeepfr

QYIKER
....|.
ellael

PP2C_2 Protein phosphatase 2C 135-334 5.9e-11 35.1 In-house 24-194 (212) alignment
Range on Protein: 135-334
Range on HMM: 24-194/212.0
VteKFCGIYDGHGGEFAAEFTEKLLSQAVLARLATAKRRQLPVNHSQILVEEILAVDEKF-----LTVAKSNEDMAGSTALVALITESDVIVANVGDSRG
.  ... . ||.|    ..   .|. .|.. .|..   .. . .....|..   .....         .... .  ..| |.|.||.  ......||.. 
g..wllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavitpgeivffqiGDgai

VMCDGSGKTVPLSYDHKPHHPQERKRIKKAGGFIAFngvwrvagilatsraigdyplkdhkfvvadpDILSFDldEHNPQFLILATDGLWDTFTNEEAV-
|. |..|.. .|. ...  .  |  .....  .  .                               .| ...   . .. |.| |||..| ...||.. 
vvrdrdgevqllgepdsgeyanettfltsedaeeel...............................rirrlk..lepgdalllmTDGvsdslrkeepfr

QYIKER
....|.
ellael

subfamily_ILKAP_pd Subfamily ILKAP 138-337 2.2e-44 144.7 In-house 44-245 (293) alignment
Range on Protein: 138-337
Range on HMM: 44-245/293.0
KFCGIYDGHGGEFAAEFTEKLLSQAVLARLATAKRRQLPVNHSQILVEEILAVDEKFLTVAKSNEDM--AGSTALVALITESDVIVANVGDSRGVMCDGS
 . ...|||.|. |.||. . | . .|..|.  .  .   .  . ||.   ..||.||. |.... .   |||| | |. .  . |||.|||. |..  .
syyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefLklaskakPvWkdGstatvvlvldnvlyvanlGdskavlvrkk

--GK---TVPLSYDHKPHHPQERKRIKKAGGFIAFNgvwRVAGILATSRAIGDYPLKDHkFVVADPDILSFDLDEhNPQFLILATDGLWDTFTNEEAVQY
  |.   .|.|. ||.| . .|||||.||||..  .   || |.|  ||.|||   |    |.. ||.   .|.| | .|..|| ||||..|...|.|..
eegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdg...rvlGvlevsrsiGdgrfkrl.GvistPdvkkceLte.ndlfvvlaCdGLwkvfsadevvkf

IKERLGE
| . |..
ilkvled

subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 139-298 5.8e-24 78.1 In-house 22-196 (292) alignment
Range on Protein: 139-298
Range on HMM: 22-196/292.0
F-CGIYDGHG--GEFAAEFTEKLLSQAVLARLataKRRQlpvNHSQILVEEILAVDEKFLTVAKSNEDMAGSTALVALITES-DVIVANVGDSRGVMCD-
|   ..||||  |.  |...|. | . .|      .. |   . |. |.  || .  |.  .   .   |....  | . .   .|.||||||| ..   
flaavldGhGvnGdkvaqlaedtlevellelt...rqlq...elsealllrildiaakldkltidaresattavvcarvrddralilanvGdsrallgrc

--GS-GKTVPLSYDHKPHHPQERKRIKKAGGFIA--------FNGVWRV------AGILATSRAIGDYPLKDHkFVVADPDI
  ||  . .||| ||||. |.||.||..|||..         |.|  ||       | || |||.||. |..   |||.|..
lggsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdfhlfea.GvvaePel

subfamily_KAPP-like_pd Subfamily KAPP-like 140-365 1.4e-25 82.8 In-house 37-266 (266) alignment
Range on Protein: 140-365
Range on HMM: 37-266/266.0
CGIYDGHGGEFAAEFTEKLLSQAVLARLATAKRRQ---LPVNHSQILVEEILAVDEKFltvakSNEDMAGSTALVALITES----DVIVANVGDSRGVMC
 ...||| |  ||. ..||. . .   |  .|. .      . |..| . .  ||.|.     .. .  |.|| .||. ..     . |||||||   ..
favfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafkevdakl.....kdfeyeGatatlalvwsdGqqrylqvanvGdssafls

DGSgKTVPLSYDHKPHHPQERKRIKKAGGFIAfNGVWRVAGIlATSRAIGDYPLKDHKF-VVADPDILSFDLDEHNPQFLILATDGLWDTFTNEEAVQYI
 |  ... ||.||| ..|.|..|||. |  .. ..  |. |. | |||.||. .|.    ....| . .  |     .|||.|.|||||  . ..|.. .
rGn.eslelskdhkakdpeekqrikddGitls.dnqtrinGl.avsralGdhfikelniGlisepyvsnrilltpfdkflivasdGlwdvisGkdaiekv

KE--RLGEPHFGAKSLVLQAFYRG--SMDNITVMVVNL
|     .. .    | .|..  .   . ||..|.||.|
kslydqqatedkmasslletaiqsikakdnvsvivvkl

subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 140-365 7.5e-23 73.8 In-house 36-276 (276) alignment
Range on Protein: 140-365
Range on HMM: 36-276/276.0
CGIYDGHGGEFAAEFTEKLLSQAVLARLAT-----AKRR---QLPVNHSQILVEEILAVDEKFltvakSNEDMAGSTALVALITESD----------VIV
 ...||| |  ||. ..||. . ..  | .     .|.    .   . |..| . .  ||.|.     .. .  |.|| .||. ..           . |
favfdGhaGkGaadaakklfpkelekllksgnysltkqddGGdniydqskllldlfkevdakl.....kdfeyeGatatlalvwsdGeeqqqqqqrylqv

ANVGDSRGVMCDGSgKTVPLSYDHKPHHPQERKRIKKAGGFIAfNGVWRVAGIlATSRAIGDYPLKDHKF-VVADPDILSFDLDEHNPQFLILATDGLWD
||||||   .. |  ... ||.|||   |.|..|||. |  .. ..  |. |. | |||.||. .|.    ....| . .  |     .|||.|.|||||
anvGdssaflsrGn.eslelskdhkatdpeekqrikddGitls.dnqtrinGl.avsralGdhfikelniGlisepyvsnrilltpfdkflivasdGlwd

TFTNEEAVQYIKER--LGEPHFGAKSLVLQAFYRG--SMDNITVMVVNL
  . ..|.. .|     .. .    | .|..  .   . ||..|.||.|
visGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivvkl

subfamily_PDP_pd Subfamily PDP 185-287 3.2e-13 42.5 In-house 132-241 (398) alignment
Range on Protein: 185-287
Range on HMM: 132-241/398.0
EEILAVDEKFLTVAKSNEDMAGSTALVALITESDVIVANVGDSRGVMCDGSG----KTVPLSYDHKPHHPQERKRIKKAGGFIAFNGVW---RVAGILAT
.|.|.  ..  .  . .  ..|..||.||| . .. |||.||.| |..  ..    ..|.|| |.  . ..| .||||.      . |    |. | |. 
tealkklkekslreallvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirngRlLgeLqP

SRAIGDYPLK
.|| ||. .|
lRAFGdvryK

subfamily_PPM1H_pd Subfamily PPM1H 189-258 1.7e-10 33.2 In-house 146-212 (404) alignment
Range on Protein: 189-258
Range on HMM: 146-212/404.0
AVDEKFLTVAKSNEDMAGSTALVALITESDVIVANVGDSRGVMCdGSGKTVPLSYDHKPHhpQERKRIKK
 .||.     .. ... | ||||||. .  . ||| |||| ...  .....||| |. |.   ||.|...
emDeqiarereayrikGGCtalvalvllgklYvanaGDsRailv.rkdeiiplsadftPe..teRqRlqe

Subfamily Dicty-PPM1L-like 191-293 1.2e-11 37.0 In-house 201-300 (305) alignment
Range on Protein: 191-293
Range on HMM: 201-300/305.0
DEKFLTVAKSNEDmAGSTALVALITESDV-IVANVGDSRGVMCDgSGKTVPLSYDHKPHHPQERKRIKKAGGF--IAFNGVWRVAGILATSRAIGDyplk
. ..| . .|  |  . . ||.   .| .  ||. .|...|..   |.   |||.... ...|  |.|. ..     || ..|| ...| .| .||    
vnrllkksrskGd.knlkelviPnndspllvvakanDqflvlat.dGlwevlsyqdvveevkellrdkssqkkiewdfneisrviveeavkrgsgD....

DHKFVV
. ..|.
nitlvi

subfamily_PPM1G_pd Subfamily PPM1G 204-337 8.7e-38 123.5 In-house 295-431 (473) alignment
Range on Protein: 204-337
Range on HMM: 295-431/473.0
MAGSTALVALITESDVIVANVGDSRGVMCDgSGKTVPLSYDHKPHHPQERKRIKKAGGFIAFNGvwRVAGILATSRAIGDYPLKDH-------KFVVADP
 .|.|| |||. | ..||||.|||| |..  .|| . ||.||||  ..|..||.|||| .  .|  || | |  |||.||.  |         . . | |
dsGttAvvaLlkekklivAnaGDsRcvlsr.nGkAldlslDHkPeDevEleRiekAGGkvdedg..RvnGGLnlsRAlGDhaYkkneeLplkeqmisAlP

DILSFDLDEHNpQFLILATDGLWDTFTNEEAVQYIKERLGE
||    | |.. .||.||.||.|.. . .| |......| .
Dikvltlteed.eFlvlAcDGiWnvmesqevvdfvraklkk

subfamily_TAB1_pd Subfamily TAB1 205-298 2.2e-13 42.7 In-house 129-236 (333) alignment
Range on Protein: 205-298
Range on HMM: 129-236/333.0
AGSTALVALITESDVIVANVGDSRGVMCD--GSGKTVPLSYDHKPHHPQERKRIKKAGgfIAFNGV--WRVAGILATSRAIGDYPLKDH-----------
 |.||.||||   .. |||||||| ...    | | . || ||.   ..| .|.|. |  .  . .   .. |   . |.|||| .|             
gGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLG..ldieqikrnkrlgskentRsiGdykvkkgykdvdilssak

-KFVVADPDI
 . |.|.|||
gePviaePdi

subfamily_PHLPP_pd Subfamily PHLPP 207-365 3.2e-15 48.7 In-house 87-245 (246) alignment
Range on Protein: 207-365
Range on HMM: 87-245/246.0
STALVALITES--------DVIVANVGDSRGVMCDGsGKTVPLSYDHKPHHPqERKRIKKAGGFIAFNGvwRVAGILATSRAIGDYPLkdHKFVVADPDI
|.||. || ..         . ||.||    |.. . || ..||  .. ..  | ||||.| ..|  ..  .. |.....| .| . |  . .|. .| .
saallilirhdkvdPaksfsLevAsvGtlqavliRn.gkklrlsksyviekd.elkrikeakaiitedn..kingviestrllGytfl..fPvvlPkphv

LSFDLDEHNpQFLILATDGLWDTFTNEEAVQYIKERlGEPHFGAKSLVLQAFYRGSMDNITVMVVNL
 .  | | .  .||.  . ||...  .|||. ...   .|   || || .|   |  |...|.||.|
revlLteqd.ellivGnkalWevlsideaveavrke.edplvaAkklvdlaqsygaadsvsvlvvrl

subfamily_PP2D1_pd Subfamily PP2D1 210-334 1.6e-25 82.8 In-house 181-305 (492) alignment
Range on Protein: 210-334
Range on HMM: 181-305/492.0
LVALITESDVIVANVGDSRGVMCDGsGKTVPLSYDHKPHHPQERKRIKKAGGFIAFNG-VWRVAGILATSRAIGDYP-LKDHKFVVADPDILSFDLDEHN
 | |.  . . .||.|. . |.| . ||.. |  .| |. ..||.|..|||. .  .. . .| ||| | | .| |  .| .| |. .| . |  |||..
evhleelgvlyianaGnvqAvLcre.GkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdpkLkksvipePkttsvkldeaa

pQFLILATDGLWDTFTNEEAVQYIKER
 |||.||. |||. ...|| .. .|. 
.qflvlAsnGlWevlseeevlsLvkqt

subfamily_PPM1H_pd Subfamily PPM1H 270-337 1.8e-09 29.9 In-house 276-353 (404) alignment
Range on Protein: 270-337
Range on HMM: 276-353/404.0
RVAGILATSRAIGDYPLKDHK-------FVVADPDILSFDLDEHN---PQFLILATDGLWDTFTNEEAVQYIKERLGE
|. . ....| .||. || ..       |. . |..  .||.. .    . ||||||||||  .|||. . ..| | .
RllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlsk

Subfamily Dicty-PPM1L-like 290-365 1.3e-08 27.1 In-house 218-303 (305) alignment
Range on Protein: 290-365
Range on HMM: 218-303/305.0
KFVVADPDILSFDLDEHNPQFLILATDGLWDTFTNEEAVQYIKERLGEPHFGA----------KSLVLQAFYRGSMDNITVMVVNL
..|. ..|   . . . | |||.|||||||. . ... |. .|| | .   .           .  | .|  ||| ||||.... |
elviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneisrviveeavkrgsgDnitlviikl

subfamily_PDP_pd Subfamily PDP 291-335 7.5e-11 34.7 In-house 269-312 (398) alignment
Range on Protein: 291-335
Range on HMM: 269-312/398.0
FVVADPDILSFDLDEhNPQFLILATDGLWDTFTNEEAVQYIKERL
.. |.|...|  | | | .||.||||||||...|||.|....| |
YltaePevtshklre.ndkFLvlatDGLwdllsneevvslVgehl

PPM_PTC7_SpoIIE_motif 310-364 6.1e-07 23.0 In-house 14-79 (81) alignment
Range on Protein: 310-364
Range on HMM: 14-79/81.0
FLILATDGLW-------DTFTNEEAVQYIKERlgE---PHFGAKSLVLQAFYRG---SMDNITVMVVN
 |.|.||||.       ..|..||........  |   .   |. || ..  .|   . |.||..|. 
vllLyTDGltEardsdgelfgkeellrladra..egkslqeladklvdevlengsgereDDitllvlr

PPM_PTC7_motif 312-358 9.3e-11 35.1 In-house 1-51 (51) alignment
Range on Protein: 312-358
Range on HMM: 1-51/51.0
ILATDGLWDTFTNEEAVQYIKERLGE----PHFGAKSLVLQAFYRGSMDNI
|||.||||| ....|||. ....| .    |   |. || .|  ||| |||
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni