Gene PTC7 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PTC7
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP193_AA protein Get Run
SpurP193_AA_59-304 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPTC7_pd Subfamily PPTC7 60-304 2.6e-111 364.0 In-house 6-251 (252) alignment 
Range on Protein: 60-304
Range on HMM: 6-251/252.0
KQGMFGDDACFVAKYKGFDVLGVADGVGGWRDYGIDPSQFPCQLMKMCKRMVKEGHFDPRSPVAIIATSYQELLEHKAPLMGSSTACIVIFDSDNKTVAS
|. ..|.||.||.. |..|||||||||||||..|||||.| ..|||.|....||.......||......||||||.|.|..||||||||..|...|...|
krqkageDayfvsseksadvlgvADGVggWrsvGiDpsefsreLmkaceklskeskaeelkPvelleaayqelleekvpvlGssTacivvldksdkkles

ANLGDSGFLIIRAGRVVHRSEEQQHYFNTPFQLSIAPPG-LRTILSDSPHSASSSLFCVKKGDIILVATDGLFDNMSEHMILGELSKLKDNSFSSVQKTV
|||||||||..| |.||.||.||||.||||.||||||.|  .....|.|..|.|. |.|||||||..||||||||..|..|| .|..||... ||.|...
anlGDSgflvvRkgkvvfrskeqqhkfntPyQLsiapegregkvildkpeaadsksfavkkgDiivlatDGlfDNlledeileilkelkeseksslqsla

NDIAAKARRLAYDPTYMSPFAMHARENGMEFTGGKPDDITVLMSTV
...|.|||.|..||.|.||||..|..||.|..|||||||||....|
kklaekarelsldpeyespfaqkakkngleasGGKpDDitvvvavv
PP2C_2 Protein phosphatase 2C 60-242 7.4e-12 38.0 Pfam-A 7-186 (212) alignment 
Range on Protein: 60-242
Range on HMM: 7-186/212.0
KQGMFGDDACFVAKYKGFDVLGVADGVGGWRdYGIDPSQFPCQLMKMC-KRMVKEGHFD-PRSPVAIIATSYQ-------ELLEHKAPLMGSSTACIVIF
..| . .||... . .....| ||||.|  . ..   ... .. .  . .. ..|. ..  .  .  | . ..       |  .....|   .|.... .
rkgkpcqDalaireasdgwllaVADGaGsak.rSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllav

dSDNKTVASANLGDSGFLII-RAGRVVHRSEEQQ-HYFNTpfqlsiappgLRTILSDSPHSASSSLFCV-KKGDIILVATDGLFDNMSEHMilgE
  ..........||.. ... |.|.|   .|...  | |.          .. . |. ...      .  ..|| .|. |||. |.....    .
.itpgeivffqiGDgaivvrdrdgevqllgepdsgeyane..........ttfltsedaeeelrirrlklepgdalllmTDGvsdslrkee...p
PP2C_2 Protein phosphatase 2C 60-242 7.4e-12 38.0 In-house 7-186 (212) alignment 
Range on Protein: 60-242
Range on HMM: 7-186/212.0
KQGMFGDDACFVAKYKGFDVLGVADGVGGWRdYGIDPSQFPCQLMKMC-KRMVKEGHFD-PRSPVAIIATSYQ-------ELLEHKAPLMGSSTACIVIF
..| . .||... . .....| ||||.|  . ..   ... .. .  . .. ..|. ..  .  .  | . ..       |  .....|   .|.... .
rkgkpcqDalaireasdgwllaVADGaGsak.rSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllav

dSDNKTVASANLGDSGFLII-RAGRVVHRSEEQQ-HYFNTpfqlsiappgLRTILSDSPHSASSSLFCV-KKGDIILVATDGLFDNMSEHMilgE
  ..........||.. ... |.|.|   .|...  | |.          .. . |. ...      .  ..|| .|. |||. |.....    .
.itpgeivffqiGDgaivvrdrdgevqllgepdsgeyane..........ttfltsedaeeelrirrlklepgdalllmTDGvsdslrkee...p
0049733 PP2C-like 62-301 4.8e-33 107.5 In-house 15-230 (235) alignment 
Range on Protein: 62-301
Range on HMM: 15-230/235.0
GMFGDDACFVakykGFDVLGVADGVGGWRDYGIDPSQFPCQLMKMCKRmvkeghFDPRSPVAIIATSYQEL--------LEHKAPLMGSSTACIVIFDsd
   ..||..|    |. ...||||.||..  ..  ....  |......      ... ......  .....        |...   .. .||.....|  
rkvneDavlv....glllfavaDGhgghaagevasellvetllellle......lllldleealrkaflaaneallelalaspelagmgtTavvalld..

NKTVASANLGDSGFLIIRAGRVVHRSEEQQHYFNTPFQLSIAPPGLRTI---------LSDSPHSASSSLFCVKKGDIILVATDGLFDNMSEHMILGELS
....  ||.||| ....| |..|...|..........|  |.. | ...         | |.....  . . ...||..|.|.|||.|..|...|.. |.
ggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggavrvpgrlaltralGdlllkpdvtvlelepgdflllasDGlwdvlsdeeivdllr

KlkdnsfSSVQKTVNDIAAKARRlaydptymspfamharengmeftGGKPDDITVLM
.       .... .. ..  |..                       .|..|.|||..
s......ldleeaaerlvelala.......................rggrDNiTvvv
0034914 PP2C-like 64-301 1.3e-26 86.3 In-house 34-287 (295) alignment 
Range on Protein: 64-301
Range on HMM: 34-287/295.0
FGDDACFVAK-----YKGFDVLGVADGVGGWRDYGIDPSQFPCQLMKMCKRMVKEGHFDPRSPVAIIATSYQEL--------LEHKAPLMGSSTACIVIF
  .||..|        ... ..||.||.||..   .  . ..  |.. .....   .... ... .. ......        |...  .....||.....
sneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellelallrpelagsGtTavvali

dsDNKTVASANLGDSGFLIIRAGRVVHRSEEQQHYFNTPFQLSIAPPGLR------------------------------TILSDSPHSASSSLFcVKKG
   ....  ||.||| ....| |..|. .... ..... ..  ... |                                 ..|  |.  . .|  ....
..rgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdfdlklllslllleplvsaePdvtvlelt.ledd

DIILVATDGLFDNMSEHMILGELSKLKDnSFSSVQKTVNDIAAKARRlaydptymspfamharengmeftGGKPDDITVLM
|..|.|.|||.|..|.. |.  ...|   .  .... .. ..  | .                       .|. |.|||. 
dfllLasDGlwdvlsneeivdivrslla.kgldleeaaeeLvdlAla.......................rgsrDNiTvvv
PP2C_SIG_SM00331 65-301 2e-19 63.0 In-house 18-214 (217) alignment 
Range on Protein: 65-301
Range on HMM: 18-214/217.0
GDDACFVAKYKGFDVLGVADGVGgwrdYGIDPSQFPCQLMKMCKRMVKEGHFDPRSPVAIIATSYQEllehKAPLMGSSTACIVIFDSDNKTVASANLGD
||  ..|.  .|  .| ||||.|     |.. . .  || .. . ...||.  .. . ...   |.|    |    .  |... ..|  ....  ||.||
GDyydvvklnegrlllvvaDgmG....kGlaAaaassqlrtalrellsegeelsqalkrlnraiyee....keekgmfaTlllalydfssgklsyanaGd

SGFLIIRAGRVVHRSEEqqhyfntpfqLSIAPPGLRTILSdsphsASSSLFCVKKGDIILVATDGLFDNMSEHMiL--GEL-SKLKDNSFSSVQKTVNDI
| ....| |. |.. ..           . || ||   .|     . .. . ..|||..| .||||....||.  .   .|   |.|.  |..|.  ..|
srpyllrdgklveilkd..........vegaplGlepevs.....vdirelelekgdllllytDGltearsekg.faeerleeiledlvdseaqelaqki

AAKARRLAYDPTYmspfamharengmeftggkPDDITVLM
 ... .|| .. .                   .|||||. 
veellelakgsng...................eDdiTvvv
SpoIIE Stage II sporulation protein E (SpoIIE) 80-303 4.2e-16 51.4 Pfam-A 7-191 (193) alignment 
Range on Protein: 80-303
Range on HMM: 7-191/193.0
LGVADGVGgwrdYGIDPSQFPCQLMKMCKRMVKEGHFdprsPVAIIATSYQELlEHKAPL-MGSSTACIVIFDSDNKTVASANLGDSGFLIIRAGRvvhR
|.|.|.||     |.. . .  .| .. ......|.     |  ...  .. | ... .      ||.....| .....  ||.|.. .|..|. .   .
lvvgDvvG....hGleAalimgllrsalrelatagle....paevlerlneal.arnleeeerfatavlaeydpstgkleyanaGhpppllvrpdg...g

SEEQQHYFNTPfqLSIAPPglrtilsdspHSASSSLFCVKKGDIILVATDGLFDNMSEHMIL----GELSKLKDNSFSSVQKTVNDIAAKARRlaydpty
 ... . .. |  |.| |           . . .  . ...||..|..|||.......   |      |. |.... .|...... . .....       
tkfllvstglp..lGilpe..........adyeeaelqlepgdllllyTDGvtEardpdgelfgkerllallaeaegesleelldalveelle.......

mspfamharengmeFT-GGKPDDITVLMST
              .. |.. ||||.|.  
..............lgsgeleDDitllvlr
SpoIIE Stage II sporulation protein E (SpoIIE) 80-303 4.2e-16 51.4 In-house 7-191 (193) alignment 
Range on Protein: 80-303
Range on HMM: 7-191/193.0
LGVADGVGgwrdYGIDPSQFPCQLMKMCKRMVKEGHFdprsPVAIIATSYQELlEHKAPL-MGSSTACIVIFDSDNKTVASANLGDSGFLIIRAGRvvhR
|.|.|.||     |.. . .  .| .. ......|.     |  ...  .. | ... .      ||.....| .....  ||.|.. .|..|. .   .
lvvgDvvG....hGleAalimgllrsalrelatagle....paevlerlneal.arnleeeerfatavlaeydpstgkleyanaGhpppllvrpdg...g

SEEQQHYFNTPfqLSIAPPglrtilsdspHSASSSLFCVKKGDIILVATDGLFDNMSEHMIL----GELSKLKDNSFSSVQKTVNDIAAKARRlaydpty
 ... . .. |  |.| |           . . .  . ...||..|..|||.......   |      |. |.... .|...... . .....       
tkfllvstglp..lGilpe..........adyeeaelqlepgdllllyTDGvtEardpdgelfgkerllallaeaegesleelldalveelle.......

mspfamharengmeFT-GGKPDDITVLMST
              .. |.. ||||.|.  
..............lgsgeleDDitllvlr
PPM_PTC7 89-184 1e-06 21.4 In-house 34-142 (259) alignment 
Range on Protein: 89-184
Range on HMM: 34-142/259.0
WRDYGIDPSQFPCQLMKMCKRMVK-----EGHFDPR-SPVAIIATSYQE--LLEHKA-------PLMGSSTACIVIFDSDNktVASANLGDSGFLIIRAG
......  ...  .. | .. ..      .  |..   . ... .|...  . |..        |. . ||| .... ...  .  ||.|||.....| |
vaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelksseantepstsGstAvvalitgsk..lyvAnvGDSravLcrsg

RVVHRSEEQQH
..|..  |...
navkqltedHk
PPM_PTC7_SpoIIE 103-249 1.4e-13 44.2 In-house 50-191 (230) alignment 
Range on Protein: 103-249
Range on HMM: 50-191/230.0
LMKMCKRMVKEGHFDPRS-PVAIIATSYQELLEH---KaPLMGSSTACIVIFDSDNKTVASANLGDSGFLIIRA-GRvvhrseeqqhyfnTPFQLsIAPP
 |.. . ...|  |   . | .|.  ....|  .   . |  . .||.....|... ..  ||.||| .|..|. |.             . ...  |. 
amgllrtalrelafaglekpeeilrrlnlalaadlede.psssgaTavvalidpstgklyvanaGdsppllvrddgg.............ereri.vagg

GLRtILSDSPHSASSSLFCVKKGDIILVATDGLFDNM--SEHMIL----GELSKLKDN
 .. .  ..   . .  .  ..||..| .|||. ..   ... .|      |  . |.
lps.lGilpgrvfgvlavslapGdllllytDGvveaepdtsdgelfgkdeflilasdg
PP2Cc_SM00332 202-301 1.4e-07 24.2 In-house 197-273 (274) alignment 
Range on Protein: 202-301
Range on HMM: 197-273/274.0
ILSDSPHSASSSLfcVKKGDIILVATDGLFDNMSEHMILGELSKLKDNSfssVQKTVNDIAAKARRLAYDPtymspfamharengmeftGGKPDDITVLM
...  |.    .|   ........|.|||.|..|.  . . . ||...    ... . ..|..  ..|..                   ||. |.|||..
yitaepdvkvvtl..tsedeflilaSDGlwdvlsnqevvdivrkllakg...ktndpqeaaelldeeairr..................ggseDniTvvv
PPM_PTC7_SpoIIE_motif 215-304 5.4e-08 26.4 In-house 7-80 (81) alignment 
Range on Protein: 215-304
Range on HMM: 7-80/81.0
FCVKKGDIILVATDGLFDNMSEHMIL----GELSKLKDNSFSSVQKTVNDIAAKARRlaydptymspfamharengmefT--GGKPDDITVLMSTV
| .|.||..|..||||......   |      |. .....  | |. .  . .....                      .  |.. ||||.|.  |
fqLkpgdvllLyTDGltEardsdgelfgkeellrladraegkslqeladklvdevle......................ngsgereDDitllvlrv