Gene LMWPTP in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC2
Superfamily CC2
Family LMWPTP
Subfamily LMWPTP
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP154_AA protein Get Run
AqueP154_AA_0-149 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_LMWPTP_pd Subfamily LMWPTP 2-150 5e-71 227.4 In-house 2-151 (152) alignment 
Range on Protein: 2-150
Range on HMM: 2-151/152.0
VKVLFVCLGNICRSPLAEAVTNKLLSDQNIK-NWTVDSAATSRYEIGSSPDHRGLRLMKRKGLTSTHRARQICHEDYDNFDYILCMDDDNVRDVRRMAPR
 ||||||||||||||.||||..||......| .|.|||||.|.|..|..||.|.|...|..||.|.||||||..||...|||||.||..|.......|..
kkvlfvClGniCrspiaEavlrklvekkglkedwkvdsaaissyhvGkepdkRalsilkkhglksshrarqitkedfsefdyilamDesnlkelkklake

KREFSAKIELLGRYDREGPDIIEDPYYGDDRDFEAVYEQCLRACTNFIRT
|.| .||..|||.||..|..|||||||||..||||||.|. ..|..|...
kkeskakvlllgeydkkgkeiiedpyygdekdFeavykqikecckaflkk
0046251 Phosphotyrosine protein phosphatases I 1-148 2.9e-48 154.1 In-house 5-155 (159) alignment 
Range on Protein: 1-148
Range on HMM: 5-155/159.0
MVKVLFVCLGNICRSPLAEAVTNKLLSDQNIKN--WTVDSAATSRYEIGSSPDHRGLRLMKRKGLTSTHRARQICHEDYDNFDYILCMDDDNVRDVRRMA
..||||||.|||||||.|||. ..||.|.....  ..||||.|| ...|..||.| ....|. |.  .|||||. .||...||.||.|||.|.||..|.|
kkkvlfvCtgNicRSpmAeallrhlledaglsdllievdSaGtsalhvgeppdpravavlkelgidlshrarqlteedfeefdlilamddsnlrdllrla

PRkrEFSAKIELLGRYDREGP---DIIEDPYYGDDRDFEAVYEQCLRACTNFI
|.  .. .|. ||. .... .     ..|||||....||.|.... .|.....
pg..dargkvllllefagllellhwdvpDPyyggleaFeevldlieeaveall
0053360 Phosphotyrosine protein phosphatases I 1-148 1.8e-47 151.4 In-house 5-153 (157) alignment 
Range on Protein: 1-148
Range on HMM: 5-153/157.0
MVKVLFVCLGNICRSPLAEAVTNKLLSDQNIKN-WTVDSAATSRYEIGSSPDHRGLRLMKRKGLTSTHRARQICHEDYDNFDYILCMDDDNVRDVRRMAP
|.||||||.|||||||.|||. ..|| ...... ..|||| || ...|...|.| ...... |.  .|||||.  ||...||.||.|||.|........|
mkkvLfvCtgNicRSpmAeallrhlleeaglgdrfevdSaGtsalhvggpvdpravevlaelgidlshrarqlteedleefdliltmddsnleellplfp

RKREFSAKIELLGRYDREGPDIIEDPYYGDDRDFEAVYEQCLRACTNFI
.  |  .|. ||. ...     ..|||||.. .||.|.... .|. ...
glleakgkvllllefagllhwdvpDPyyggleafelvldlieeaveall
0048765 Phosphotyrosine protein phosphatases I 1-148 2.6e-47 150.8 In-house 2-150 (154) alignment 
Range on Protein: 1-148
Range on HMM: 2-150/154.0
MVKVLFVCLGNICRSPLAEAVTNKLLSDQNIKN-WTVDSAATSRYEIGSSPDHRGLRLMKRKGLTSTHRARQICHEDYDNFDYILCMDDDNVRDVRRMAP
|.||||||.|||||||.|||. ..||....... ..|||| || | .|...|.| ...... |.  .|||||. .||...||.||.|||.|........|
mkkvLfvCtgNicRSpmAeallrhlleeaglgdrvevdSaGtsayhvgepvdpravevlaelgidlshrarqlteedleefdliltmddsnleellplfp

RKREFSAKIELLGRYDREGPDIIEDPYYGDDRDFEAVYEQCLRACTNFI
.  |  .|. ||.....     ..|||||.. .||.|.... .|. ...
glleakgkvllllefagllhwdvpDPyyggleafeevldlieeaveall
0042188 Phosphotyrosine protein phosphatases I 1-149 1.3e-41 132.2 In-house 4-141 (146) alignment 
Range on Protein: 1-149
Range on HMM: 4-141/146.0
MVKVLFVCLGNICRSPLAEAVTNKLLSDQniknWTVDSAATSRYEIGSSPDHRGLRLMKRKGLTST-HRARQICHEDYDNFDYILCMDDDNVRDVRRMAP
..||||||.|||||||.|||. ..||.|.    ..|||| || | .|...|.| ...... |.  . |||||.  ||...||..|.|||.|.||.....|
kkkvlfvCtgNicRSpmAeallrhllgdr....vevdSAGtsayhvgepvdpravevlaelgidisghrarqlteedleefDlvltmddsnlrdllplfp

rkREFSAKIELLGRYDregpdIIEDPYYGDdRDFEAVYEQCLRACTNFIR
  ..  .|. ||...       ..|||||.  .||.|.... .|. ....
..gaakgkvllllefw.....dvpDPyygg.eafeevldlieeavkalle
LMWPc Low molecular weight phosphotyrosine protein phosphatase 4-148 1.9e-41 132.2 Pfam-A 1-138 (138) alignment 
Range on Protein: 4-148
Range on HMM: 1-138/138.0
VLFVCLGNICRSPLAEAVTNKLLSDQNIKNWTVDSAATSRYeIGSSPDHRGLRLMKRKGLTST-HRARQICHEDYDNFDYILCMDDDNVRDVRRMAPRkr
|||||.|||||||.|||. ..|| ..  ....||||.|. . .|.|.|.| ....|.||.  . |||||. .|....||.||..|....|.....||.  
vlfvCtgNicRSpmAeallrallekalgdkvevdSAGteal.vgesvdpravevlkekgidisghrarqlseeelkefDliltldeeaarelcpvape..

EFSAKIELLGRydregPDIIEDPYYGDDRDFEAVYEQCLRACTNFI
.  ||. |||         |.|||.... .||.|.... .......
kkeakvvllge.....qwdipDPygkeeeefeevrdeieervkkll
LMWPc Low molecular weight phosphotyrosine protein phosphatase 4-148 1.9e-41 132.2 In-house 1-138 (138) alignment 
Range on Protein: 4-148
Range on HMM: 1-138/138.0
VLFVCLGNICRSPLAEAVTNKLLSDQNIKNWTVDSAATSRYeIGSSPDHRGLRLMKRKGLTST-HRARQICHEDYDNFDYILCMDDDNVRDVRRMAPRkr
|||||.|||||||.|||. ..|| ..  ....||||.|. . .|.|.|.| ....|.||.  . |||||. .|....||.||..|....|.....||.  
vlfvCtgNicRSpmAeallrallekalgdkvevdSAGteal.vgesvdpravevlkekgidisghrarqlseeelkefDliltldeeaarelcpvape..

EFSAKIELLGRydregPDIIEDPYYGDDRDFEAVYEQCLRACTNFI
.  ||. |||         |.|||.... .||.|.... .......
kkeakvvllge.....qwdipDPygkeeeefeevrdeieervkkll
LMWPc_SSU72_ArsC 3-140 4.4e-38 121.0 In-house 2-126 (126) alignment 
Range on Protein: 3-140
Range on HMM: 2-126/126.0
KVLFVCLGNICRSPLAEAVTNKLLSDqnikNWTVDSAATSRYEIGSSPDHRGLRLMKRKGLTSTHRARQICHEDYDNFDYILCMDDDNVRDVRRMAPRKr
|||||||||||||| |||| .|....    .. |.||.|.... |.|.|.|   |.|..|.  .|..||.  || ..||.||.||..|...|....|.. 
kvlfvClgNicRSpmAeavlkkavkk....glnvsSaGtgaavpgksidsravellkengielkhkprqlqeedlkefdliltmdernkdevlellper.

eFSAKIELLgrydregPDIIEDPYYGDDRDFEAVYEQC
   .|..||          ..|||.|.  .|| |....
.atkkvhll.......nldvkDpyegaesgfeevldli
0051181 Phosphotyrosine protein phosphatases I 3-148 9.7e-37 115.9 In-house 1-122 (124) alignment 
Range on Protein: 3-148
Range on HMM: 1-122/124.0
KVLFVCLGNICRSPLAEAVTNKLLSDqniknWTVDSAATsryEIGSSPDHRGLRLMKRKGLTSTHRARQICHEDYDNFDYILCMDDDNVRDVRRMAPrkr
||||||.|||||||.|||. ..||.|     ..|||| |   ..|...|.| ...... |.  ..|..|.  .|...||..|.|||.|.......||   
kvlfvCtgNicRSpmAeallrhllgd.....vevdSAGt...hpggpvdpravevlaelgidlslrskqldeldleefdlvltmddsnlcpllplap...

E---FsakiellgrydregpdIIEDPYYGDDRDFEAVYEQCLRACTNFI
.   .                 ..|||||.. .||.|.... ... ...
lllhw................dvpDPyyggleefeevldlieerveall
0047618 Phosphotyrosine protein phosphatases I 1-148 3.4e-35 111.2 In-house 1-133 (137) alignment 
Range on Protein: 1-148
Range on HMM: 1-133/137.0
MVKVLFVCLGNICRSPLAEAVTNKLLSDQniknWTVDSAATSRYEigssPDHRGLRLMKRKGLTST-HRARQICHEDYDNFDYILCMDDDNVRDVRRMAP
..||||||.|||||||.|||. ..||.|.    ..|||| |. ..    .|.| ...... |.  . ||..|. ..|...||..|.|||.........||
kkkvlfvCtgNicRSpmAeallrhllgdr....vevdSAGtepag....vdpravevlaelgidisghrskqldeldlpefdlvltmddsalealpllap

RKREFSAkiellgrydregpdIIEDPYYGD------DRDFEAVYEQCLRACTNFI
. . .                 ..|||||.       ..|| |.... ... ...
aalrlhw..............dvpDPyygggteeekleafervldlieerveall
0047572 Phosphotyrosine protein phosphatases I 1-148 4.9e-33 104.0 In-house 2-128 (130) alignment 
Range on Protein: 1-148
Range on HMM: 2-128/130.0
MVKVLFVCLGNICRSPLAEAVTNKLLsdqnIKNWTVDSAATSryeiGSSPDHRGLRLMKRKGLTS-THRARQICHEDYDNFDYILCMDDDNVRDVRRMAP
..||||||.||.||||.|||. ..||     ....|.|| |.    ||..|.| ...... |.   .||..|. ......||....|||.........||
kkkvlfvCtgNscRSpmAeallrhll....gdrvevySAGte....gsgvdpravevlaelgidisghrskqldelllpefdlvitmddsalealpllap

RKREFSAkiellgrydregpdIIEDPYYGDDRDFEAVYEQCLRACTNFI
... .                 |.|||.|....|..|.... |.. ...
aalrlhw..............dipDPygggleafrevrdlierrvlall
LMWPc_SSU72 3-148 3.3e-31 99.0 In-house 2-135 (137) alignment 
Range on Protein: 3-148
Range on HMM: 2-135/137.0
KVLFVCLGNICRSPLAEAVTNKLLSdqnikNWTVDSAATSRYEIGSSPDHRGLRLMKRKGLTSTHRARQICHEDYDNFDYILCMDDDNVRDVRRMAPRKR
||||||..||.||. |||. .. |.     ...|.|| |. . .|.|.|..  .|.|..||  .......  |. ..||............| ...|...
kvlfVCasNinRSmeAeallkeale.....glevkSaGtgslvpgpsidkpaeelykenGlsikeapeklqeeelekfDlvitleervfdavvedlpers

EFSAKIELLgrydregPDIIEDPYYGDDRDFEAVYEQCLRACTNFI
|  .|. ..          |.||....  .|.|..... ... ...
elkrkvhvi.......nvdikDpheeaiegfkaildlieervkell
subfamily_Sponge-LMWPTP-like_pd Subfamily Sponge-LMWPTP-like 3-41 4.3e-08 22.9 In-house 2-39 (173) alignment 
Range on Protein: 3-41
Range on HMM: 2-39/173.0
KVLFVCLGNICRSPLAEAVTNKLLSDQNiKNWTVDSAAT
|.|||| || ||||.|  |..|. .... |    |||| 
kllfvcsgnscrspmamivaekmeaere.kiiesdsaag