Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
subfamily_Sponge-LMWPTP-like_pd | Subfamily Sponge-LMWPTP-like | 30-202 | 8.5e-123 | 396.3 | In-house | 1-173 (173) | alignment | ||
Range on Protein: 30-202
Range on HMM: 1-173/173.0
SKLLFVCSGNSCRSPMAMIVAEKMEAEREKIIESDSAAGNFKNGKFVASQSPARNAIKALEAEYGRTRLEEYEPKPLKKEDIEKADKVIFLGAEFRKNAE
|||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||.||||||||||||||||||||||.|||||||
skllfvcsgnscrspmamivaekmeaerekiiesdsaagnfkngkfvasqspavnaikaleaeygrtrlkeyepkplkkediekadkviflgvefrknae
DAKKLFGDALDGKAMYYCTYVNKQDSKDKERHEVPDPLDGDNWPEYYGEEKPGRGQFRSYTKVLKSMIKDFYP
||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||.|||||.||||||
dakklfgdaldgkamyyctyvnkqdskdkerhevpdpldgdnwpeyygeekpgrrqfrsyakvlkslikdfyp
|
|||||||||
0046251 | Phosphotyrosine protein phosphatases I | 29-201 | 1.2e-16 | 51.7 | In-house | 5-155 (159) | alignment | ||
Range on Protein: 29-201
Range on HMM: 5-155/159.0
PSKLLFVCSGNSCRSPMAMIVAEKMEAEREKI---IESDSAAGNFKNgkfvASQSPARNAIKALEAeYGRTRLeeYEPKPLKKEDIEKADKVIFLGaefR
. |.|||| ||.|||||| ..... .... || |||. . ..| ..|...|. .| . .. |..||.|..| .. .. .
kkkvlfvCtgNicRSpmAeallrhlledaglsdllievdSaGtsalh....vgeppdpravavlke.lgidls..hrarqlteedfeefdlilamd...d
KNAEDAKKLFGDALDGKAMYYCTYVNKQDskdKERHEVPDPLDGDnwpeyygeekpgRGQFRSYTKVLKSMIKDFY
.|..| ..|. . . || .... ... . . ..|||| |. . |. . .. .....
snlrdllrlapgdargkvllllefaglle...llhwdvpDPyygg............leaFeevldlieeaveall
|
|||||||||
0042188 | Phosphotyrosine protein phosphatases I | 29-199 | 2e-16 | 50.8 | In-house | 4-138 (146) | alignment | ||
Range on Protein: 29-199
Range on HMM: 4-138/146.0
PSKLLFVCSGNSCRSPMAMIVAEKMEaerEKIIESDSAAgnfkNGKFVASQSPARNAIKALEAEygRTRLEEYEPKPLKKEDIEKADKVIFLGAEfrkNA
. |.|||| ||.|||||| ..... .. .| ||| . .. .... . |...|.. .... ...|..||.|..| |. .. . |.
kkkvlfvCtgNicRSpmAeallrhll...gdrvevdSAG....tsayhvgepvdpravevlael..gidisghrarqlteedleefDlvltmdds...nl
EDAKKLFGDALDGKAMYYCTYVnkqdskdkerhEVPDPLDGDNwpeyygeekpgrgQFRSYTKVLKSMIKD
.|. .|| .|. || .... .. .|||| |.. |. . ... .|.
rdllplfpgaakgkvllllefw...........dvpDPyygge.............afeevldlieeavka
|
|||||||||
0053360 | Phosphotyrosine protein phosphatases I | 29-197 | 2.1e-16 | 50.8 | In-house | 5-149 (157) | alignment | ||
Range on Protein: 29-197
Range on HMM: 5-149/157.0
PSKLLFVCSGNSCRSPMAMIVAEKMEAEREKI--IESDSAAGnfknGKFVASQSPARNAIKALEAeYGRTRLeeYEPKPLKKEDIEKADKVIFLGAefrK
. |.|||| ||.|||||| ..... .|.. .| ||| . . .... . |...|. .| . ...|..||.|..| .. .. .
mkkvLfvCtgNicRSpmAeallrhlleeaglgdrfevdSaGt....salhvggpvdpravevlae.lgidls..hrarqlteedleefdliltmdd...s
NAEDAKKLFGD--ALDGKAMYYCTYVnkqdskDKERHEVPDPLdgdnwpeYYGEEkpgrgQFRSYTKVLKSMI
|.|.. .|| . || .... .. . . ..|||| | |.| |. . . .....
nleellplfpglleakgkvllllefa......gllhwdvpDPy.......yggle.....afelvldlieeav
|
|||||||||
0048765 | Phosphotyrosine protein phosphatases I | 30-199 | 3.1e-16 | 50.2 | In-house | 3-148 (154) | alignment | ||
Range on Protein: 30-199
Range on HMM: 3-148/154.0
SKLLFVCSGNSCRSPMAMIVAEKMEAEREKI--IESDSAAGnfknGKFVASQSPARNAIKALEAeYGRTRLeeYEPKPLKKEDIEKADKVIFLGAefrKN
|.|||| ||.|||||| ..... .|.. .| ||| . .. .... ..|...|. .| . ...|..||.|..| .. .. .|
kkvLfvCtgNicRSpmAeallrhlleeaglgdrvevdSaGt....sayhvgepvdpravevlae.lgidls..hrarqlteedleefdliltmdd...sn
AEDAKKLFGD--ALDGKAMYYCTYVNKqdskdkERHEVPDPLdgdnwpeYYGEEkpgrgQFRSYTKVLKSMIKD
.|.. .|| . || .... ... . ..|||| | |.| |. . .......
leellplfpglleakgkvllllefagl......lhwdvpDPy.......yggle.....afeevldlieeavea
|
|||||||||
LMWPc | Low molecular weight phosphotyrosine protein phosphatase | 33-170 | 7.7e-15 | 46.0 | Pfam-A | 2-119 (138) | alignment | ||
Range on Protein: 33-170
Range on HMM: 2-119/138.0
LFVCSGNSCRSPMAMIVAEKMEAER-EKIIESDSAAGNfkngKFvASQSPARNAIKALEAEygRTRLEEYEPKPLKKEDIEKADKVIFLGAEfrkNAEDA
|||| ||.|||||| ..... .. .. .| |||. . . ..|. ..|...|. . .... ...|..|.....| .. | .| .|...
lfvCtgNicRSpmAeallrallekalgdkvevdSAGte....al.vgesvdpravevlkek..gidisghrarqlseeelkefDliltldee...aarel
KKLFGDALDGKAMYYCTyvnkqdskdkeRHEVPDPLDGD
.... .| . . . ..||| ..
cpvapekkeakvvllge...........qwdipDPygke
|
|||||||||
LMWPc | Low molecular weight phosphotyrosine protein phosphatase | 33-170 | 7.7e-15 | 46.0 | In-house | 2-119 (138) | alignment | ||
Range on Protein: 33-170
Range on HMM: 2-119/138.0
LFVCSGNSCRSPMAMIVAEKMEAER-EKIIESDSAAGNfkngKFvASQSPARNAIKALEAEygRTRLEEYEPKPLKKEDIEKADKVIFLGAEfrkNAEDA
|||| ||.|||||| ..... .. .. .| |||. . . ..|. ..|...|. . .... ...|..|.....| .. | .| .|...
lfvCtgNicRSpmAeallrallekalgdkvevdSAGte....al.vgesvdpravevlkek..gidisghrarqlseeelkefDliltldee...aarel
KKLFGDALDGKAMYYCTyvnkqdskdkeRHEVPDPLDGD
.... .| . . . ..||| ..
cpvapekkeakvvllge...........qwdipDPygke
|
|||||||||
0047618 | Phosphotyrosine protein phosphatases I | 31-174 | 8.4e-15 | 45.4 | In-house | 3-112 (137) | alignment | ||
Range on Protein: 31-174
Range on HMM: 3-112/137.0
KLLFVCSGNSCRSPMAMIVAEKMEAERekiIESDSAAGNFKNgkfvasqsPARNAIKALEAeyGRTRLEEYEPKPLKKEDIEKADKVIFLGAEfrkNAED
|.|||| ||.|||||| ...... ..| .| ||| .. . ..|...|. .... .|.| ..|....| |. .. . . |.
kvlfvCtgNicRSpmAeallrhllgdr...vevdSAGtepag........vdpravevlae..lgidisghrskqldeldlpefdlvltmdds...alea
AKKLFGDALDGKAmyyctyvnkqdskdkerhEVPDPLDGDNWPE
|...|| . .|||| |.. .|
lpllapaalrlhw..................dvpDPyygggtee
|
|||||||||
0051181 | Phosphotyrosine protein phosphatases I | 31-171 | 2e-14 | 44.2 | In-house | 1-104 (124) | alignment | ||
Range on Protein: 31-171
Range on HMM: 1-104/124.0
KLLFVCSGNSCRSPMAMIVAEKMEAErekiIESDSAAGnfkngkfVASQSPARNAIKALEAEYGRTRleeYEPKPLKKEDIEKADKVIFLGAEfrkNAED
|.|||| ||.|||||| ..... .. .| ||| ..... . |...|. . . .|.|...|.|..| |. .. . | ..
kvlfvCtgNicRSpmAeallrhllgd....vevdSAGt.......hpggpvdpravevlaelgidls...lrskqldeldleefdlvltmdds...nlcp
AKKLFGdaldgkamyyctyvnkqdskDKERHEVPDPLDGDN
|. . ..|||| |.
llplap....................lllhwdvpDPyyggl
|
|||||||||
0047572 | Phosphotyrosine protein phosphatases I | 30-170 | 1.1e-13 | 41.6 | In-house | 3-109 (130) | alignment | ||
Range on Protein: 30-170
Range on HMM: 3-109/130.0
SKLLFVCSGNSCRSPMAMIVAEKMEAERekiIESDSAAGNfkngkfvaSQSPARNAIKALEAeyGRTRLEEYEPKPLKKEDIEKADKVIFLGAEfrkNAE
|.|||| ||||||||| ...... ..| .| .|| . ... .|...|. .... .|.|........| || .. . . |
kkvlfvCtgNscRSpmAeallrhllgdr...vevySAGte........gsgvdpravevlae..lgidisghrskqldelllpefdlvitmdds...ale
DAKKLFGDALDGKAmyyctyvnkqdskdkerhEVPDPLDGD
. |...|| ..||| |.
alpllapaalrlhw..................dipDPyggg
|
|||||||||
LMWPc_SSU72_ArsC | 31-166 | 1.4e-11 | 35.4 | In-house | 2-111 (126) | alignment | |||
Range on Protein: 31-166
Range on HMM: 2-111/126.0
KLLFVCSGNSCRSPMAMIVAEKMEAErekIIESDSAAGNFKNgkfvASQSPARNAIKALEAE-YgrtRLEeYEPKPLKKEDIEKADKVIFLGAEfrkNAE
| ||||.||.|||||| | .|. .. .. .||. . . .|. ..|...|... . .|. |..|..||....| .... . | .
kvlfvClgNicRSpmAeavlkkavkk...glnvsSaGtgaav....pgksidsravellkengi...elk.hkprqlqeedlkefdliltmder...nkd
DAKKLFGDAlD-GKAMYYctyvnkqdskdkeRHEVPDP
. ..|. | .|.||
evlellper.atkkvhll.............nldvkDp
|
|||||||||
subfamily_LMWPTP_pd | Subfamily LMWPTP | 31-154 | 1.8e-10 | 30.8 | In-house | 3-116 (152) | alignment | ||
Range on Protein: 31-154
Range on HMM: 3-116/152.0
KLLFVCSGNSCRSPMAMIVAEKMEAEREKI--IESDSAAgnfkNGKFVASQSPARNAIKALEaEYGRTRLeeYEPKPLKKEDIEKADKVIFLGAEfrkNA
|.|||| || ||||.| .| .|. .... . |||| .. ..| . |...|. ..|... . ..||| .. | .. . . |
kvlfvClGniCrspiaEavlrklvekkglkedwkvdsaa....issyhvGkepdkRalsilk.khglkss..hrarqitkedfsefdyilamDes...nl
EDAKKLFGDALDGKAMyyCTYVNKQD
.. ||| . . || . . ..|
kelkklakekkeskak..vlllgeyd
|
|||||||||
LMWPc_SSU72 | 31-124 | 2.9e-09 | 27.9 | In-house | 2-84 (137) | alignment | |||
Range on Protein: 31-124
Range on HMM: 2-84/137.0
KLLFVCSGNSCRSPMAMIVAEKMEAerekIIESDSAAgnfkNGKFVASQSPARNAIKALEAEYGrtRLEeYEPKPLKKEDIEKADKVIFLGAEF
|.||||..|..||..| ..... . .| .|| |. | .|. ..| ...... ... |. |..|. ||.| || | .
kvlfVCasNinRSmeAeallkeale....glevkSaG....tgslvpgpsidkpaeelykenGl..sik.eapeklqeeelekfDlvitleerv
|