Gene AqueLMWPTP-like-2 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC2
Superfamily CC2
Family LMWPTP
Subfamily AqueLMWPTP-like
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP156_AA protein Get Run
AqueP156_AA_8-171 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-LMWPTP-like_pd Subfamily Sponge-LMWPTP-like 10-182 1e-122 396.1 In-house 1-173 (173) alignment 
Range on Protein: 10-182
Range on HMM: 1-173/173.0
SKLLFVCSGNSCRSPMAMIVAEKMEADRGKIIESDSAAGNFKNGKFVASQSPAVNAIRALEAVYGQTRLKEYTPKPLKKEDIEKADKVIFLGVEFRKNAE
||||||||||||||||||||||||||.|.||||||||||||||||||||||||||||.||||.||.||||||.|||||||||||||||||||||||||||
skllfvcsgnscrspmamivaekmeaerekiiesdsaagnfkngkfvasqspavnaikaleaeygrtrlkeyepkplkkediekadkviflgvefrknae

DAKKLFGDALDGKAMYYCTYVNKQDSKDKERHEVPDPLDGDNWPEYYGEEKPGYRQFSSYAKVLKSMIQDFYP
|||||||||||||||||||||||||||||||||||||||||||||||||||||.|||.||||||||.|.||||
dakklfgdaldgkamyyctyvnkqdskdkerhevpdpldgdnwpeyygeekpgrrqfrsyakvlkslikdfyp
0046251 Phosphotyrosine protein phosphatases I 9-171 5.3e-17 52.9 In-house 5-145 (159) alignment 
Range on Protein: 9-171
Range on HMM: 5-145/159.0
PSKLLFVCSGNSCRSPMAMIVAEKMEADRGKI---IESDSAAGNFKNgkfvASQSPAVNAIRALEAVYGQTRlkeYTPKPLKKEDIEKADKVIFLGvefR
. |.|||| ||.||||||  ..... .|.|     || |||.    .      ..|  .|...|. .   .    .... |..||.|..| .. ..   .
kkkvlfvCtgNicRSpmAeallrhlledaglsdllievdSaGtsalh....vgeppdpravavlkelgidls...hrarqlteedfeefdlilamd...d

KNAEDAKKLFGDALDGKAMYYCTYVNKQDskdKERHEVPDPLDGDnwpeyygeekpgYRQFSSYAK
.|..| ..|. . . || .... ...  .    . ..||||  |.            .. |    .
snlrdllrlapgdargkvllllefaglle...llhwdvpDPyygg............leaFeevld
0042188 Phosphotyrosine protein phosphatases I 9-152 1.3e-16 51.4 In-house 4-124 (146) alignment 
Range on Protein: 9-152
Range on HMM: 4-124/146.0
PSKLLFVCSGNSCRSPMAMIVAEKMEADRgkiIESDSAAgnfkNGKFVASQSPAVNAIRALEAVygQTRLKEYTPKPLKKEDIEKADKVIFLGvefRKNA
. |.|||| ||.||||||  ..... .||   .| |||      . .. ....   |...|...  .  ........|..||.|..| |. ..   ..|.
kkkvlfvCtgNicRSpmAeallrhllgdr...vevdSAG....tsayhvgepvdpravevlael..gidisghrarqlteedleefDlvltmd...dsnl

EDAKKLFGDALDGKAMYYCTYVnkqdskdkerhEVPDPLDGDNW
.|. .|| .|. || .... ..           .||||  |...
rdllplfpgaakgkvllllefw...........dvpDPyyggea
0053360 Phosphotyrosine protein phosphatases I 9-150 2.7e-16 50.4 In-house 5-134 (157) alignment 
Range on Protein: 9-150
Range on HMM: 5-134/157.0
PSKLLFVCSGNSCRSPMAMIVAEKMEADRGKI--IESDSAAGnfknGKFVASQSPAVNAIRALEAVYGQTRlkeYTPKPLKKEDIEKADKVIFLGVefrK
. |.|||| ||.||||||  ..... ...|    .| |||      . .  ....   |...|. .   .    .....|..||.|..| .. ..    .
mkkvLfvCtgNicRSpmAeallrhlleeaglgdrfevdSaGt....salhvggpvdpravevlaelgidls...hrarqlteedleefdliltmdd...s

NAEDAKKLFGD--ALDGKAMYYCTYVnkqdskDKERHEVPDPLDGD
|.|.. .|| .     || .... ..      . . ..||||  |.
nleellplfpglleakgkvllllefa......gllhwdvpDPyygg
0048765 Phosphotyrosine protein phosphatases I 10-150 3.8e-16 50.0 In-house 3-131 (154) alignment 
Range on Protein: 10-150
Range on HMM: 3-131/154.0
SKLLFVCSGNSCRSPMAMIVAEKMEADRGKI--IESDSAAGnfknGKFVASQSPAVNAIRALEAVYGQTRlkeYTPKPLKKEDIEKADKVIFLGVefrKN
 |.|||| ||.||||||  ..... ...|    .| |||      . .. ....  .|...|. .   .    .....|..||.|..| .. ..    .|
kkvLfvCtgNicRSpmAeallrhlleeaglgdrvevdSaGt....sayhvgepvdpravevlaelgidls...hrarqlteedleefdliltmdd...sn

AEDAKKLFGD--ALDGKAMYYCTYVNKqdskdkERHEVPDPLDGD
.|.. .|| .     || .... ...       . ..||||  |.
leellplfpglleakgkvllllefagl......lhwdvpDPyygg
0047618 Phosphotyrosine protein phosphatases I 11-155 7.3e-15 45.6 In-house 3-113 (137) alignment 
Range on Protein: 11-155
Range on HMM: 3-113/137.0
KLLFVCSGNSCRSPMAMIVAEKMEADRgkiIESDSAAGNFKNgkfvasqsPAVNAIRALEAvyGQTRLKEYTPKPLKKEDIEKADKVIFLGVEfrkNAED
|.|||| ||.|||||| ...... .||   .| |||    ..        .  .|...|.    .  ......|.| ..|....| |. .. .   . |.
kvlfvCtgNicRSpmAeallrhllgdr...vevdSAGtepag........vdpravevlae..lgidisghrskqldeldlpefdlvltmdds...alea

AKKLFGDALDGKAmyyctyvnkqdskdkerhEVPDPLDGDNWPEY
   |...||  .                   .||||  |.. .| 
lpllapaalrlhw..................dvpDPyygggteee
LMWPc Low molecular weight phosphotyrosine protein phosphatase 13-150 2.2e-14 44.5 Pfam-A 2-119 (138) alignment 
Range on Protein: 13-150
Range on HMM: 2-119/138.0
LFVCSGNSCRSPMAMIVAEKMEADR-GKIIESDSAAGNfkngKFvASQSPAVNAIRALEAVygQTRLKEYTPKPLKKEDIEKADKVIFLgveFRKNAEDA
|||| ||.||||||  .....  .. |. .| |||. .     .  ..|.  .|...|.    . .... ....|..|.....| .. |    ...|...
lfvCtgNicRSpmAeallrallekalgdkvevdSAGte....al.vgesvdpravevlkek..gidisghrarqlseeelkefDliltl...deeaarel

KKLFGDALDGKAMYYCTyvnkqdskdkeRHEVPDPLDGD
....     .| .  .            . ..|||  ..
cpvapekkeakvvllge...........qwdipDPygke
LMWPc Low molecular weight phosphotyrosine protein phosphatase 13-150 2.2e-14 44.5 In-house 2-119 (138) alignment 
Range on Protein: 13-150
Range on HMM: 2-119/138.0
LFVCSGNSCRSPMAMIVAEKMEADR-GKIIESDSAAGNfkngKFvASQSPAVNAIRALEAVygQTRLKEYTPKPLKKEDIEKADKVIFLgveFRKNAEDA
|||| ||.||||||  .....  .. |. .| |||. .     .  ..|.  .|...|.    . .... ....|..|.....| .. |    ...|...
lfvCtgNicRSpmAeallrallekalgdkvevdSAGte....al.vgesvdpravevlkek..gidisghrarqlseeelkefDliltl...deeaarel

KKLFGDALDGKAMYYCTyvnkqdskdkeRHEVPDPLDGD
....     .| .  .            . ..|||  ..
cpvapekkeakvvllge...........qwdipDPygke
0051181 Phosphotyrosine protein phosphatases I 11-150 2.5e-14 43.9 In-house 1-103 (124) alignment 
Range on Protein: 11-150
Range on HMM: 1-103/124.0
KLLFVCSGNSCRSPMAMIVAEKMEADrgkiIESDSAAGnfkngkfVASQSPAVNAIRALEAVYGQTRlkeYTPKPLKKEDIEKADKVIFLGVEfrkNAED
|.|||| ||.||||||  ..... .|    .| |||          .....   |...|. .  ..    ...|.|...|.|..| |. .. .   | ..
kvlfvCtgNicRSpmAeallrhllgd....vevdSAGt.......hpggpvdpravevlaelgidls...lrskqldeldleefdlvltmdds...nlcp

AKKLFGdaldgkamyyctyvnkqdskDKERHEVPDPLDGD
   |.                       . ..||||  |.
llplap....................lllhwdvpDPyygg
0047572 Phosphotyrosine protein phosphatases I 10-150 1.3e-13 41.5 In-house 3-109 (130) alignment 
Range on Protein: 10-150
Range on HMM: 3-109/130.0
SKLLFVCSGNSCRSPMAMIVAEKMEADRgkiIESDSAAGNfkngkfvaSQSPAVNAIRALEAvyGQTRLKEYTPKPLKKEDIEKADKVIFLGVEfrkNAE
 |.|||| ||||||||| ...... .||   .| .||  .         ...  .|...|.    .  ......|.|........| || .. .   . |
kkvlfvCtgNscRSpmAeallrhllgdr...vevySAGte........gsgvdpravevlae..lgidisghrskqldelllpefdlvitmdds...ale

DAKKLFGDALDGKAmyyctyvnkqdskdkerhEVPDPLDGD
.   |...||                      ..|||  |.
alpllapaalrlhw..................dipDPyggg
LMWPc_SSU72_ArsC 11-146 3.4e-12 37.4 In-house 2-111 (126) alignment 
Range on Protein: 11-146
Range on HMM: 2-111/126.0
KLLFVCSGNSCRSPMAMIVAEKMEADrgkIIESDSAA-GNFKNGKFVASQSPAVNAIRALeavygqtRLKeYTPKPLKKEDIEKADKVIFLGvefRKNAE
| ||||.||.||||||  | .|. ..    .. .||. |.   || . |.. .. . . .       .||  .|..|..||....| ....    ..| .
kvlfvClgNicRSpmAeavlkkavkk...glnvsSaGtgaavpgksidsravellkengi.......elk.hkprqlqeedlkefdliltmd...ernkd

DAKKLFGDAlD-GKAMYYctyvnkqdskdkeRHEVPDP
. ..|.       |                   .|.||
evlellper.atkkvhll.............nldvkDp
subfamily_LMWPTP_pd Subfamily LMWPTP 11-122 2.7e-10 30.3 In-house 3-106 (152) alignment 
Range on Protein: 11-122
Range on HMM: 3-106/152.0
KLLFVCSGNSCRSPMAMIVAEKMEADRGKI--IESDSAA-GNFKNGKfvasqSPAVnaiRALEAVYGQTRLKEYTPKPLKKEDIEKADKVIFLGvefRKN
|.|||| || ||||.| .| .|. ...|     . ||||  ... ||     .|     |||...  . . .. . . ..||| .. | .. .     .|
kvlfvClGniCrspiaEavlrklvekkglkedwkvdsaaissyhvGk.....epdk...RalsilkkhglksshrarqitkedfsefdyilamD...esn

AEDAKKLFGDALDGK
 .. |||  .  . |
lkelkklakekkesk
LMWPc_SSU72 11-101 1.3e-09 29.0 In-house 2-81 (137) alignment 
Range on Protein: 11-101
Range on HMM: 2-81/137.0
KLLFVCSGNSCRSPMAMIVAEKMEAdrGKIIESDSAAGNFkNGKFVASQSPAVNAIRALeavygqtRLKeYTPKPLKKEDIEKADKVIFLG
|.||||..|..||..|  ..... .  |  ..|         |. .  ..... . . |       ..|  .|. |..|. ||.| || | 
kvlfVCasNinRSmeAeallkeale..glevkSaGtgslv.pgpsidkpaeelykenGl.......sik.eapeklqeeelekfDlvitle