Gene PPP1C-1 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP1C
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP174_AA protein Get Run
AqueP174_AA_5-305 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP1C_pd Subfamily PPP1C 23-301 1.6e-162 532.4 In-house 2-280 (282) alignment
Range on Protein: 23-301
Range on HMM: 2-280/282.0
SRPGKNVQLTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLL
|..||.|.|.||.|. |. |.|||.||||||||||||.||.|||||||.|||||||..|.|||||||||||||||||||||||.||||||||||||.|||
skkgkevklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfll

RGNHECASINRIYGFYDECKRRYNIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWADPDKETVAWGENDR
|||||.|||||||||||||||||.|.|||||||.|||||.||..||||.|.||||||.|.|.||||.|.||..||..||||||||.|||||.. |.||||
rGnhesasinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendr

GVSFTFGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAS
|||||||...|.||| |.|||||.||||||||||||||||||||.|||||||||||||||..||||.|..||||||||.
GvsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpak

subfamily_PPZ_pd Subfamily PPZ 9-300 3.7e-139 456.4 In-house 2-294 (300) alignment
Range on Protein: 9-300
Range on HMM: 2-294/300.0
NVDNIIQKLLEVR-GSRPGKNVQLTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICL
..|.||||||.    ..  ||| | ...|  .| |.||.||.|| ||||  ..|| ||.|||| ||||||   |||| .||||||||||||||||||| |
dideiiqklldagyaakrtknvclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletill

LLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLW
||.||||||||||||||||||| . |.|||||||||| ||..|||| | || ||.|||.  |||| |||||| |.||..||...||||||| ||. ||||
llcykikypenffllrgnhecanvtrvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllw

ADPDKETVAWGENDRGVSFTFGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA
.||   .  | .|.||||. .    . ||| |  .||.|||| |||||||||  | |||.|||||||||||| ||.||| | |.|||..| | 
sdptdssnewednergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldpl

subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 9-301 3.9e-136 445.9 In-house 2-295 (298) alignment
Range on Protein: 9-301
Range on HMM: 2-295/298.0
NVDNIIQKLLEVRGSRPGKNVQLTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLL
.||... ..|.|  |      ...|.|.  |. ....|| .|. |.|..||.|.|||||||| ||||||. .||||..||||||||||||.|.||.|.||
evdellievlsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivll

LAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRY-NIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLW
||||.|||.|||||||||||..|||.||||.|||||| ..||...| | || ||..|.. ..|.| |||||. |.|..|.|.. ||.| ... |  ||||
laykvkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllw

ADPDKETVAWGENDRGVSFTFGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAS
|||.. .  | || ||||..|| . | ..| | |.||..|||||| |||||||...|||.||||.|||.|||. |.|.||| |..||..|||..
adpenavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpek

subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 9-302 1.2e-127 418.3 In-house 2-296 (299) alignment
Range on Protein: 9-302
Range on HMM: 2-296/299.0
NVDNIIQKLLEVRGSRPGKNVQLTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLL
.||... |||.|  |       . | ... ||  ....|.||. |||.|||...|||||||| ||||.|.  ||||..|.||||||||||.| ||.|.||
dvdellskllnvgmsekrltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitll

LAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYN-IRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLW
|..||||||.||.||||||| .|||.||||.||..||.  |||  | |.|. .|.. ..  .|.| |||||| ||...|.| . || | |.  |  ||||
lcfkikyperffmlrgnhecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllw

ADPDKETVAWGENDRGVSFTFGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPASD
||||.  . |  | ||||. ||...|.. . . |.||..||||||.|||||||...|||.|||| |||.|||. |.| ||| |.|.|..|||.. 
adpdqsvkdwlanvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpk

subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 31-300 4.3e-120 393.1 In-house 6-275 (280) alignment
Range on Protein: 31-300
Range on HMM: 6-275/280.0
LTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECAS
. |||| ..  | ..|.. |  ..|..||...|||.|||| ||||||.  .|||..||||||||||||.| || |.||||||..||.||..||||||..|
ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevis

INRIYGFYDECKRRYNIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWADPDKETVAWGENDRGVSFTFGP
||| |||.||.||||.  |.. | . .. ||..|..  .|.| |||||..|.|........|| | .|. |  |||||||....  |.|| ||||  || 
inrkygfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifga

EIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA
..| ..  | |.|||.| ||||.|||||||...|||.||||.|.|||||. |.. ||| |. ||..||||
nvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpa

0045823 Metallo-dependent phosphatases 9-303 7.5e-119 390.3 In-house 21-327 (473) alignment
Range on Protein: 9-303
Range on HMM: 21-327/473.0
NVDNIIQKLLEVRGSRPGKNVQLTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLL
 .... .  |..  ..  |. .|.| |.. |. . .||. ..| ||||.... ..||||||..|||||.|  ||||| ...||||.|||| .|||...||
lfillglldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlell

LAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWA
||.|||||.|.||||||||.. .| .|||.||. ..|...|.. | .....||.||....||...||||||||....|||.| || ..|| |||.||||.
lalkikypgnvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllws

DPdKETVA--------WGENDRGVSFTFGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQ------LVTLFSAPNYCGEFDNAGAMMSVDETLmCSF
||  |.          .| . ||....|||..| .|| |..||||.|.|..|..|||.. ...      ..|.||||||||...| .|.. .||.| .||
dP.weddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isf

QILKPASDR
....|... 
iqfdpsphp

0049330 Metallo-dependent phosphatases 6-305 4.4e-116 380.2 In-house 5-304 (309) alignment
Range on Protein: 6-305
Range on HMM: 5-304/309.0
DKLNVDNIIQKLLEVRGSRPGKNVQLTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETI
|.| ....|..||..  ... | ..|.| ... |.|| .||..|.|.||||.... ..||||||..|||||.|  ||||| ...||||.|||| .|||..
dpllllelilslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevl

CLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDL
.||||.|..||.|.||||||||.. .|..|||.||..|.|...||. |.|....||.||....||.|.||||||||....|||...||...|. ||||||
llllalkllypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdl

LWADPDKETVAWGENDRGVSFTFGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPASDRRK
||.||. ..  ...|.||....||. .| .|| |..||||.|.|..|..||..|....|.|.||||||||...|.||.. .||.|..||....|..   .
lwsdplpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpllll





PP2Ac_SM00156 32-300 2.5e-115 377.2 In-house 2-270 (271) alignment
Range on Protein: 32-300
Range on HMM: 2-270/271.0
TEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASI
.. ... |. ...||. ... |.|..||. ..||||||..|||||.| .|.|||..|.|||||||||.||.|.|.||.|.||.|||...|||||||. |.
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

NRIYGFYDECKRRYNIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWADPDKETVAWGENDRGVSFTFGPE
|.||||..|.||.|. .... |...|..||.||..|.||.| ||||||.|.|...||.. |. . |..|||.||||.||....  .  . ||.|..||..
nkiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFged

IVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA
.|..|| |..|.||.|||.||..||||||...|||.|||||||.||.|..|...|...|..|.. ||..
avkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq

PPP_1 33-286 1.5e-113 371.5 In-house 3-264 (264) alignment
Range on Protein: 33-286
Range on HMM: 3-264/264.0
EADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASIN
|. .. |. |..|.. ....|||.......|||||||..|||.||..||..||.|||||||||||||.|.|...||||.|.|||...||||||||.....
eeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvt

RIYGFYDECK-RRYNIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLL-------WADPDKETVAWGENDRGV
..|||..|.. ..|. ...||.||.|..||.||..||||...||||||.|....|||...| |.||..| |||||       . |..... |. ...||.
kvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRGa

SFTFGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSV
...||.....||| |..|.||.|||.|.|.||||..||..||.|||.||. |..|.||....
gylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvkl

PPP_3 31-298 1.3e-112 368.3 In-house 2-270 (271) alignment
Range on Protein: 31-298
Range on HMM: 2-270/271.0
LTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECAS
|.| ... |. | .||. ....|.|..||...|||||||..|||.||..||..||..||||||||||||.|||...||||.|||||....|||||||...
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

INRIYGFYDECK-RRYNIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWADPDKETVAWGENDRGVSFTFG
||..|||..|.. .... ...|.....|..||.||..|||....||||||...|..||... |...||..|.|.|||. ......  .....||....||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

PEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILK
|.....|| |..|.||.|||...|.|||.......||.|||||||....||||.....|.|...|..|.
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle

subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 31-299 1.2e-111 365.8 In-house 8-282 (284) alignment
Range on Protein: 31-299
Range on HMM: 8-282/284.0
LTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFP------PESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRG
|.| ..  ||...||.|  ... ||.|||.||.||||||. ||| |..  |.|       |..|||||||||||  |.| | ||.|||...|.. |||||
lkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrg

NHECASINRIYGFYDECKRRYNIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWADPDKETVAWGENDRGV
|||   .|. |||| |||.||  .|...|  .||..|..|....||.| |||.| || ...|. .. ||.|.|| |...|| ||||..| . . | .|| 
nhesrpvnmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesprga

SFTFGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKP
  .||.. | .|| |..|||. |||||| ||||||| |.|||.|||| |||..||..|...||| |..||..|||
gkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkp

subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 10-301 5.4e-107 350.5 In-house 2-296 (297) alignment
Range on Protein: 10-301
Range on HMM: 2-296/297.0
VDNIIQKLLEVRGSRPGKNVQLTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLL
||.||  .|            .||  .  |   . ..| .|  ..|..||.|.|||||||. ||||||  ||.|| .||||||||||||. |.||| |||
vdsiiidvlsasthekllskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlll

AYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYN-IRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSP---DLQSMEQIRRIMRPTDVpDQGLLCDL
|||.|.| |.|||||||||  .|..||||.||..||. .|.. .| | || ||.. .. .||.| ||||||   .  ... .|.| |.|.   ..|..||
aykvkfpgnlfllrgnhecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadl

LWADPDKETVAWGENDRGVSFTFGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAS
|||||      . ||.||    || . | |   . .|||.|||||||.||||||| |.|||.|||| |||.|||. |.||.|| | |||.||.|.|
lwadpisglsgfmenqrgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilrpts

subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 34-301 5.2e-106 347.2 In-house 6-275 (284) alignment
Range on Protein: 34-301
Range on HMM: 6-275/284.0
ADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINR
 |.  | ... .||  ||.|.| ..|..||||||||. ||||||.  |||  .|||||||||||||. |||| ||.|||. .|. ||.|||||||. ||.
edvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslink

IYGFYDECKRRYNI-RLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQG-LLCDLLWADPDKETVAWGENDRGVSFTFGPE
|||||.||.||||   ....|   |  .|..|.. ..|.| |||.|  || . |.| | || | |.   |  |.||.|| .    |  | ||||. || .
iygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsd

IVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAS
 . |.| . ..||. ||||||.|||||||.|.|||.|||| |||.|||| |.| |.. |.||| .|.|  
alrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrprk

0053225 Metallo-dependent phosphatases 12-299 2.9e-105 344.7 In-house 3-290 (293) alignment
Range on Protein: 12-299
Range on HMM: 3-290/293.0
NIIQKLLEVRGSRPGKNVQLTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAY
..|. ||..  ..  ....|.| ... |.|. .||....|.||||.... ..|||||...|||.|.|. |||||....||||.|||| .|||...||||.
slilllldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllal

KIKYPENFFLLRGNHECASINRIYGFYDECKRRY-NIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWADP
|..||.|..|||||||.. .| .|||.||..|.| . .||. ..|....||.||....||...|||||||| ...|||.|.||...|. |||.|||| ||
kllypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdp

DkETVAWGENDRGVSFTFGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKP
| .   |. . ||....||. .| .|| |..||||.|.|||| |||... ...|||.||||||.|...|.||.. .|| |...|....|
d.lwsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfap

subfamily_PPP4C_pd Subfamily PPP4C 31-300 2.3e-102 335.1 In-house 16-285 (288) alignment
Range on Protein: 31-300
Range on HMM: 16-285/288.0
LTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECAS
..| ... || |.|||.. .  . ....|  .|||||||.||||.||. ||  || |||||||.||||. |.||. ||||.|..||..  |.|||||. .
ikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrq

INRIYGFYDECKRRY-NIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWADPDKETvAWGENDRGVSFTFG
| ..||||||| |.| ....|.  |. |. |..|||.|.|||| ||||||.......|| | | ..||..| ||||||.||.. . .|.   ||  . ||
itqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedae.gwavsprgagylfg

PEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA
 ..|..|  . |..|||||||.| .|| .  .....|..||||||    |  |.. .||.|   |.|.. |
sdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaa

subfamily_PPP2C_pd Subfamily PPP2C 28-302 2.3e-100 328.5 In-house 14-288 (290) alignment
Range on Protein: 28-302
Range on HMM: 14-288/290.0
NVQLTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHE
  ||.|.... || | .||. ..  . |...|. .|||.|||..||| ||  ||  |..||||||||||||  |.||..|| | |..|.|   .||||||
ckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhe

CASINRIYGFYDECKRRY-NIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWADPDkETVAWGENDRGVSF
   | ..||||||| |.| |  .|| ||| |..||..|..||.||| |||||| ......|| . |  .||..| ||||||.||| .   ||  .||  .
srqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpd.drggwgisprgagy

TFGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPASD
||| .|  ||  . .| || ||||.| .||..  .|..||.|||||||    | .|.. .|..|  ||   .||. 
tfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpapr

subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 28-302 9.8e-99 323.1 In-house 5-279 (281) alignment
Range on Protein: 28-302
Range on HMM: 5-279/281.0
NVQLTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHE
.||.|. .|  .  . . || ..  | |...| .. ||.|.|. || ||||  | .||  ..|||||||||.||||.. ||...||.|... .|||||||
kvqytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnhe

CASINRIYGFYDECKRRYNIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWADPDKETVAWGENDRGVSFT
 ||.|.||||| ||. .| . ||  |  ||| ||..|  .... | ||||||.| .....| . .| . .|.||. ||||||||...  | .  ||.|||
iasvnkiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssft

FGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPASD
|| ..| .   . ...|| |||||| |||| .. |.|.|.||.||||  . ||.|.. |||||  |.. | ||| 
fGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpase

subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 86-301 9.3e-98 320.3 In-house 101-316 (317) alignment
Range on Protein: 86-301
Range on HMM: 101-316/317.0
SNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSME
..|||||||||||  |.| . ||.|.|..||.. ||||||||  ..|. |||| |.|.||. .|...|   ||.||..|....||.| |||.| .| ...
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldlk

QIRRIMRPTDVPDQGLLCDLLWADPDKETVAWGENDRGVSFTFGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMS
|. .. ||.|.|| |.|.|| |||||.|   . |  || .. ||.. | .|| |.||||. |||||||||||||| |.|||.||||.|||..||..|..|
qldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavls

VDETLMCSFQILKPAS
||. |..|...|.| |
vdkklkisinvlrpes

subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 31-300 1.2e-94 309.5 In-house 10-282 (287) alignment
Range on Protein: 31-300
Range on HMM: 10-282/287.0
LTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECAS
... ||  .  | .||.   | |||.|||..|.||||||. ||||.|.  | .|. .||||||||||| .||| . ||...||.||..  |||||||.  
fsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkk

INRIYGFYDECKRRYNIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVP--DQGLLCDLLWADPDKETVAWGEN-DRGVSFT
||..|||..| ||... ||.|.| | |. ||. |.....|.| |||.||.|.|..... . .||     |.||  |||||||.|.. .   |  |..|  
inklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisvv

FGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA
|| . | ..| | |.||| |||.|.|.||.|.....|||.|||| |.||  | ||.. |...|  ||  ||| 
fGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkpe

subfamily_PPP6C_pd Subfamily PPP6C 30-303 5e-93 304.4 In-house 14-287 (290) alignment
Range on Protein: 30-303
Range on HMM: 14-287/290.0
QLTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECA
 |.|.|.. || .  ...| .  .  ...|. .|||||||.|||. ||  ||  |...|.||||.||||  ||||. .||. |.|||..  |||||||. 
ylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesr

SINRIYGFYDECKRRY-NIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWADPDkETVAWGENDRGVSFTF
 | ..|||||||...| |   || .|. |. |..|||.||...| |||||||.. ..||| | | ...| .| .|||.|.||. .  .|   .||  . |
qitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpe.dvetwavsprgagylf

GPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPASDR
| .....|.   .|.|||||||.||.|.... . .|||..||||||    |  ........   .....|   |.
gskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfkavpde

subfamily_PPP3C_pd Subfamily PPP3C 28-291 1.3e-88 290.8 In-house 38-314 (452) alignment
Range on Protein: 28-291
Range on HMM: 38-314/452.0
NVQLTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHE
. .|.|...  .  .. ... ... |||.|||. ..||||||.||||.||| || | ...|||||||||||  |.|..  |.| ||.||...||||||||
egrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhe

CASINRIYGFYDECKRRYNIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWADPDKET------VAWGEN-
|  .   . | .||| .|. .........|..||.||.|... .|.||||||...|...|... |  ..| .|.||||||.|| ..        .. .| 
crhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpns

DRGVSFTFGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAK------RQLVTLFSAPNYCGEFDNAGAMMSVDETLM
 || |. .. . |..|| | ||  | |||.. ..||. . |        |.||||||||.. ..| .|.. ...  |
vrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennvm

subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 38-300 3.5e-86 282.1 In-house 13-275 (280) alignment
Range on Protein: 38-300
Range on HMM: 13-275/280.0
GLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGF
 .      ||. .  | | |||.|. |||| || |. |||.  |  || . .||||||||| | .| . ||.. ||.| .  .|||||||  |.|.||||
aiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiygf

YDECKRRYNIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWADPDKETVAWGENDRGVSFTFGPEIVSKFL
| ||. .| . ||  |  ||| .|..... ....| ||||||.|  .. || | || .  |.||| ||||.|| ..  .|  . ||.|. ||  .| .  
yvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkgvveqac

CKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA
   ..||| ||||||.||||..| |.|.|.|| |||| .| || |.. ..  |  ||| | | 
ksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlipp

subfamily_PPG1_pd Subfamily PPG1 30-301 2.9e-85 279.2 In-house 13-297 (300) alignment
Range on Protein: 30-301
Range on HMM: 13-297/300.0
QLTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECA
 | |. .. |. | .|.....  . |...|. . ||.|||.||.| .|. ||  |..||||||||||||  |.||| ||.. |..||    |||||||  
llpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesr

SINRIYGFYDECKRRY--NIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWADPD-----------KETVA
 | ..|||| || |.|  | |.|| .|. |. | .|||.||.|.| ||||||. .|..||. . |  .||..| |.||||.||.           .|   
qitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqh

WGENDRGVSFTFGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAS
. . .||  ...| ..| ||| . |.. | ||||.. .||. .   .| |..||||||    |  ... . | .   |.. . | 
fvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeeap

subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 31-300 2.8e-84 275.5 In-house 16-289 (290) alignment
Range on Protein: 31-300
Range on HMM: 16-289/290.0
LTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECAS
... ||  .  | .||.   | |||.|||. | ||||||  .||| |.  |.||. ..|||||||||| .|||   ||. |||.|...  |||||||.  
fsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrk

INRIYGFYDECKRRYNIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTD--VPDQGLLCDLLWADPDK---ETVAWgENDRGVS
.||.|||..|  |. . |||| . | |. |.. | ...||.| |||.|....| | .. . .|      |.||  |||||||..   .|.|  .  |..|
vnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtial.nkqrais

FTFGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA
  || . . ..| |  |.|| |||.| |.|..|  ...|||.|||| |.|.  | ||.. | |.|  |. .||| 
vvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkpr

subfamily_PPP5C_pd Subfamily PPP5C 40-288 5.8e-84 274.8 In-house 43-297 (322) alignment
Range on Protein: 40-288
Range on HMM: 43-297/322.0
CLKSREIFLSQPILLELEAP----LKICGDIHGQYYDLLRLFEYGGFPPES-NYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRI
 |...|.. ..| |.|.. .    | .|||||||.|||| .||  | | |.  ||| ||.||||  |.|.| .||..|. ||..||| |||||  ..|..
lleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnkl

YGFYDECKRRYNIRLWKTFTDCFNCLPVAAILDEKIFCCHGGL-SPDLQSMEQIRRIMRPTDVPDQGLLCDLLWADPDKETvAWGENDRGVSFTFGPEIV
||| .|.| .|. .. . ||. || ||.| ...||.. .|||| | |  .....|.| | .. |..|||..|||.||....   ..  |||...|||.. 
yGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqean.GrspskrGvgvqfGpdvt

SKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSV-DE
.||| . .|.|| |.|.| |.|||.  . .|.|.||||||| . .| ||.... ..
kkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgd

PPP_2 61-251 9e-82 266.5 In-house 2-197 (198) alignment
Range on Protein: 61-251
Range on HMM: 2-197/198.0
KICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECK-RRYNIRLWKTFTDCFNC
..|||.|||..|||.||..|...||..||||||||||||.|||...||||.|..||....|||||||....|..|||..|.. .... ...|.....|..
tvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfel

LPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLL----WADPDKETVAWGENDRGVSFTFGPEIVSKFLCKHDLDLICRAHQV
||.||..|||....|||||.......||... |....|..|.|.|||    . ||....  . .. ||....|||......| |..|.||.|||.|
LplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev

PPP_4 61-251 2.4e-78 255.7 In-house 2-196 (197) alignment
Range on Protein: 61-251
Range on HMM: 2-196/197.0
KICGDIHGQYYDL-LRLFEYGGFPP-ESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIRLWKTFTDCFN
 ..||||||..|| |.|...||.|. |..|.||||||||||.|||...||||.|..||....|||||||..|.|..|||..|...... ...|...|.|.
tvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvfd

CLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVP-DQGLLCDL-LWADPDKETVAWGENDRGVSFTFGPEIVSKFLCKHDLDLICRAHQV
.||.||..|||....|||||..|.|...|.|| |....| ......|| ||.|| ...  . .. ||....|||....||| |..|.||.|.|..
llplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel

subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 28-303 9.7e-77 251.1 In-house 17-295 (307) alignment
Range on Protein: 28-303
Range on HMM: 17-295/307.0
NVQLTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHE
..| |  ..  .  ... || |.  |.... |  . ||.|||. ||. .|   | |||. |.| |||||||  |||.| ||..||| ||||  |||||||
kiqytkeefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnhe

CASINRIYGFYDECKR---RYNIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWADPDKETVAWGENDRGV
 | .|. ||||.||     .    .|  |  ||| ||..|..  ||.| |||||| |  ....|   .|   | .|.. |.||||||   . |    || 
iarvnkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgs

SFTFGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPASDR
 |||| ...     .  ..|| ||||.. |||  .. |.|.|.|||| ||  . |||... |||||      . |.|. 
gftfgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpesen

subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 87-304 8.8e-76 248.2 In-house 121-338 (339) alignment
Range on Protein: 87-304
Range on HMM: 121-338/339.0
NYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQ
 |||||||||||  |.| . || | |. ||.  .|||||||  |.|  |||| | . ||. .|.. | . || .|..|.... |.| |||.|  | |..|
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfnq

IRRIMRPTDVPDQGLLCDLLWADPDKETVAWGENDRGVSFTFGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSV
.  . || ..|| |.| || |||||     .    || || |||  .  || | ||... | |||||||||||  |.|||.||||||||. ||. |..|.
fsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfsi

DETLMCSFQILKPASDRR
|. |  | ....| |  .
dkklkisinvfrpesrdk

PPP_5_Dcr2 61-252 1.3e-74 243.5 In-house 2-199 (199) alignment
Range on Protein: 61-252
Range on HMM: 2-199/199.0
KICGDIHGQYYDL-LRLFEYGGFPP-ESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRR-YNIRLWKTFTDCF
 .|||.|||..|| |.||. ||.|. | .|.||||||||||.|||...||||.|..||....|||||||. ..|.||||..|.... .. ...|...|.|
tvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdvf

NCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVP-DQGLLCDL-LWADPD-KETVAWGENDRGVSFTFGPEIVSKFLCKHDLDLICRAHQVV
..||.||..|||....||||||...|.|....| |....| ..|  .|| ||.||  . .  . .. ||....|||....||| |..|.||.|.|...
dwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk

subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 53-300 3.6e-72 236.2 In-house 2-256 (263) alignment
Range on Protein: 53-300
Range on HMM: 2-256/263.0
LLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNI-----
||||.||..|||| |||| ||||.|.  |   ...||||||||||| .||| | ||.. |.  | ...|||||||  .||. |||. | |.|..      
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

RLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPD-QGLLCDLLWADPDKETVAWGEND-RGVSFTFGPEIVSKFLCKHDLDLI
 ... | . |. .|..||. ..|.| |||.|| |.|...|| |  | .    . | ||||||||.|..  .  |  | .|  || . |  .  . |.|||
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidli

CRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA
 ||||||| || ||| |.|.|.|||  |  |. |  |.. |.. |  ||  ||| 
vrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkpe

subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 30-298 1.9e-68 223.8 In-house 5-298 (302) alignment
Range on Protein: 30-298
Range on HMM: 5-298/302.0
QLTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYG------------GFpPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPE
.... ..  |. .  | .  .  | |. .|. | ||||||. ||.|.. .             .|  .. ..|||||||||..|.| |||..|.|. ||.
eysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysf.ssdkfvflGdyvdrGsksieciclvfalkvlypt

NFFLLRGNHECASINRIYGFYDECKRRY----NIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRP-TDVPDQGLLCDLLWADP-D
|. |||||||. .||  ||| .| . |.      ..|. | ..|  .|.||.. |||.| |||.|| |.|.|.|..| || ..| .. |  |||.||| |
nyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpld

KET-------VAWGEN-DRGVSFTFGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILK
 ..        .. .|  ||.|..|    | ..  . .|.|| ||||..  |. |||...|.|.||||.|  | || ||.. ||     | ..|.
vqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlr

subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 30-298 3.5e-68 223.0 In-house 6-299 (302) alignment
Range on Protein: 30-298
Range on HMM: 6-299/302.0
QLTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYG------------GFpPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPE
.... ..  |. .  | .  .  | |. .|. | ||||||. ||.|.. .             .|  .. ..|||||||||..|.| |||..|.|. ||.
eysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysf.ssdkfvflGdyvdrGsksieciclvfalkvlypt

NFFLLRGNHECASINRIYGFYDECKRRY----NIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIRRIMRP-TDVPDQGLLCDLLWADP-D
|. |||||||. .||  ||| .| . |.      ..|. | ..|  .|.||.. |||.| |||.|| |.|.|.|..| || ..| .. |  |||.||| |
nyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpld

KET-------VAWGEN-DRGVSFTFGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILK
 ..        .. .|  ||.|..|    | ..  . .|.|| ||||..  |. |||...|.|.||||.|  | || ||.. ||     | ..|.
vqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlr

subfamily_PPPLV_pd Subfamily PPPLV 38-290 3.2e-55 180.5 In-house 4-279 (290) alignment
Range on Protein: 38-290
Range on HMM: 4-279/290.0
GLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLL----RLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINR
 || .. .|....  ||||..|  . ||.||.| ||      |.  |     ...||||||||||. |.| |. ||| |. ||  ..|||||||  |.  
slcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqe

IYGFYDECKRRYNIRL---WKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQI---RRIMR--PTDVPDQGLLCDLLWADPDKET-----------
 . .. |.. ..  .|   |..|...|. ||.||..|.|.||.|.|.    ..  .|   . |.   . |.    |  |.||.||...            
sieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvln

VAWGEND-RGVSFTFGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAgAMMSVDETL
  . .|| || .  |. . . .|| . .|. . |||.| | |...  | .|.|.||. .|||  ..| |.. ||.  
eGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssnea.alilvdkkk

Metallophos Calcineurin-like phosphoesterase 60-251 3.9e-44 144.3 Pfam-A 3-198 (200) alignment
Range on Protein: 60-251
Range on HMM: 3-198/200.0
LKICGDIHGQYYDL----LRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLL--LAYKIKYPENFFLLRGNHECASINRIYGFYDECK-----------
  ..||.||...||    |.|.. .. ..  ..|||||.||||. |.||..||  |..|...| ..||||||||. ..|  |||..|.            
ilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglangee

-----------------------RRYNIRLWKTFTDCFNCLPVAAILDEKIFCCHGGLSPDLQSMEQIrrimrptdvpdqgllcdllwadpdketvawge
                        ... . .  . ..|..|| .|. | ||...||.||....| ..|                                
eyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi................................

ndrgVSFTFGPEIVSKFLCKHDLDLICRAHQV
     |. |||. ..|.| |...||..|.|. 
....gselfgpdalekllekygvdlvlrGHtH

subfamily_PPP7C_pd Subfamily PPP7C 60-192 3.6e-38 124.3 In-house 66-201 (383) alignment
Range on Protein: 60-192
Range on HMM: 66-201/383.0
LKICGDIHGQYYDLLRLFEYGGFPPE-SNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRY---NIRLWKTFTD
. .|||.||.  ||| ..   |.| |  .|.| ||.|||||.|.| ...|||. . ||....| |||||   .|  |||  | . .|   . .. ... |
vtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlled

CFNCLPVAAILDEKIFCCHGGLSpDLQSMEQIRRIMR
 |  ||.|...||||. .|||.| |  ..| . .| |
vfawlplatlidekilivhGGis.dktdlelldkier

subfamily_PPP7C_pd Subfamily PPP7C 202-294 2.9e-20 65.4 In-house 237-329 (383) alignment
Range on Protein: 202-294
Range on HMM: 237-329/383.0
LCDLLWADPDKETVAWGENDRGVSFTFGPEIVSKFLCKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSF
. |.||.|| ...  . .  ||    |||.. .|.| |..|.|. |.|.   .||||  .....|.||| ||  |  | || . . ..|.  .
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltpri

subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 31-84 7.2e-17 54.5 In-house 9-62 (317) alignment
Range on Protein: 31-84
Range on HMM: 9-62/317.0
LTEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPP
..|...  ||...||.| ..|. ||||||..|.||||||. ||| |..  |.| 
fkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwpl

subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 32-85 1.9e-12 39.9 In-house 12-65 (339) alignment
Range on Protein: 32-85
Range on HMM: 12-65/339.0
TEADIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPE
  |..  || ..||.  |.||.|.||||. . ||||||. ||| ...  |.|  
caaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmngwpls

subfamily_YNL217W_pd Subfamily YNL217W 61-178 7.6e-08 25.1 In-house 13-137 (235) alignment
Range on Protein: 61-178
Range on HMM: 13-137/235.0
KICGDIHGQYYDLLRLFE--YGGFPPESNYLFLGDYVDRGKQSLETICLLlaykikYPENFFLLRGNHECASINRIygfydECKRRYNI-----------
 . ||.|| | .|..|..   ||  ..   ...|| ...| .|.|.. ..        ..   ..|||| . . ..     .  .. .            
lvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllay.....kwvkkpkgaeplefsskfs

----RLWKTFTDCFNCLPVA-AILDEKIFCCHGGLS
    .| |  ..    |. .  |  ....  |.||.
flesklskadmeyarelgfsldipsdellvvhaGlv