Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
subfamily_PPP3C_pd | Subfamily PPP3C | 40-404 | 5.9e-139 | 456.7 | In-house | 41-322 (452) | alignment | ||
Range on Protein: 40-404
Range on HMM: 41-322/452.0
LERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSytnsehlirregaattsqdiptdpshkeeegscppsqvscpplptlINGyys
||..... .||||.||.|.|.|||...|||.|||||||||.||...|. ..|
leeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfe..............................................vgG...
fdpkplqghnsikKPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsyaegINFAEECQSKYGEETYESFMRCFDSLPLA
.|.|..|||||||||||..|.||.|.|.|||.||||..|.||||||.|..|.. ..|.|||..||.||.|...|..|||||||
.............dPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrhltey.....ftfkeeckikyseevydacmesfdslPla
AIVENKFgkwLCCHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPLleevlgrrmsdKDYQEFL-EIDYLPNPPRGCSCFYGYLAITPFLNNNDL
|.....| ||.|||....||||..|..|.|||||| |||.|||.||||| .||.|. | ...||..||||.||.| |...||..|||
allnqqf...lcvhGGlspeikslddikkldrfkeppasGplcdllWsdPl...........edygeekteekfvpnsvrGcsyfysykavceflqkndl
LGIIRAHQCKEEGigyaYTNNRK-ELFPFPLVTTLFSASNYCGSYTNKGAILLIYTDDIKVIKYRSG
|.|||||.....| |...|| |...||...|||||.||...|.||.|.| ............|
lsiiraheaqdaG....yrmyrkseatgfPslitlfsapnyldvynnkaavlkyennvmnirqfnss
|
|||||||||
0045823 | Metallo-dependent phosphatases | 36-402 | 8.8e-87 | 284.7 | In-house | 39-322 (473) | alignment | ||
Range on Protein: 36-402
Range on HMM: 39-322/473.0
NYKLLERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSYTNsehlirregaattsqdiptdpshkeeegscppsqvscpplptlin
. .||. . . |..|| ...| | .||.||..||||||||||. || .. .
kegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekig.............................................
gyysfdpkplqghnsikKPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFSYaeginFAEECQSKYGEETYESFMRCFDS
|.. ..||||.|||| .| |....|||||..||...|.||||||.| ... | .|. ||||. || |.....|
.................fppedrlvflGDlvDrGpdslevlelllalkikypgnvfllrGNHElrllnglyg.....fgdetlekygedlyeeflewlrs
LPLAAIVeNKfgKWLCCHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPllEEVLGRRmsdkdyqeFLEIDYLPNPPRGCSCFYGYLAITPFLNN
|||||.. .. |.|..|||. . ...| |...||. |.| .|...|| |||| .|. | . .| . . .| |||.....|. |. ||..
lPlaavi.gg..kilfvHGGlspdlplldqireierpleipddgllldllwsdP..weddgdg........llrlrffgnsprgagylFgpdaveeflkk
NDLLGIIRAHQCKEEGIGYAYTNNRkelFPFPLVTTLFSASNYCGSYTNKGAILLIYTDDIKVIKYR
|.| |.|.|.. .||. . . ... . .. . |.|||.|||| . |..|.|.| | |..| ..
ngldlivrGHthvpeGyellfdgkv...igiDtgiTvfSApnYcgrggnlaAvlvidedlisfiqfd
|
|||||||||
PP2Ac_SM00156 | 42-394 | 7.4e-77 | 251.0 | In-house | 3-259 (271) | alignment | |||
Range on Protein: 42-394
Range on HMM: 3-259/271.0
RSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFsytnsehlirregaattsqdiptdpshkeeegscppsqvscpplptlingyysfd
.. | |.||. ...| |..|...|||..|.||||||. ||. ..
keevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrll.......................................................
pkplqghNSIKKPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTqfsyaEGINFAEECQSKYGEETYESFMRCFDSLPLAAI
.. ..|.. |.||||||||| .| |.||.|.|||..||.....|||||||. .. . | ||.. |||.|.|| |...|..|||||.
.......elageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssvn.....kiygfeeevkrkygkeiyekfeeafsllPlaal
VENKFgkwLCCHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPlleevlgrrmsdkdyqEFLEIDYLPNPpRGCSCFYGYLAITPFLNNNDLLGI
|..|. || |||. ....|| .|..|.|.||.| .|...||.|||| | | .. |. ||.|...| |.. ||..|.| |
vdski...lcmhGGlspeleslddirklkrvkekpeegllidllwsdp................eqkekgfqpsk.rglsvvFgedavkeflkknnlkli
IRAHQCKEEGigYAYTNNRkelfpfpLVTTLFSASNYCGSYTNKGAILLIYTD
||||....|| | . .. . |.|||.|||....||.|.| ....
iRahevvdeG..yeffadk.......klvtifsapnycdefsnkaavlkvekn
|
|||||||||
0049330 | Metallo-dependent phosphatases | 36-398 | 2.2e-75 | 246.7 | In-house | 26-292 (309) | alignment | ||
Range on Protein: 36-398
Range on HMM: 26-292/309.0
NYKLLERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSYTNSEhlirregaattsqdiptdpshkeeegscppsqvscpplptlin
..|||. . . |...| ...|.| .||.||..||||||||||. || .. .
klkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfp...........................................
gyysfdpkplqghnsikkPHsPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFSYaeginFAEECQSKYGEETYESFMRCFDS
| ..||||.|||| .| |..|.|||||..||...|.||||||.| .... | .|.. |||.| .| |.....|
..................pe.drlvflGDlvdrGpdslevlllllalkllypdnvfllrGNHElrllnglyg.....fgdetlrkygaelweefldwlrs
LPLAAIVENkfgKWLCCHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPLLEEVLgrrmsdkdyqefleidYLPNPpRGCSCFYGYLAITPFLNN
|||||.... |.||.|||. . ...|..|..|||. |.|| |..|||.||||| . ..||| ||.....|. |. ||.
lplaavigg...kilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpireg................fapnp.rglgvvfghtaverflkk
NDLLGIIRAHQCKEEGIGYAYTNNrkelfpfplVTTLFSASNYCGSYTNKGAILLIYTDDIKV
|.| |||.|.. ..|. . . .. . |.|||.|||| . |.||.|.| | .
ngldliirghgavfgGyltffdgk.........litvfsapnycgrlgnlgavleidedlvis
|
|||||||||
0053225 | Metallo-dependent phosphatases | 36-394 | 1.1e-69 | 228.1 | In-house | 18-280 (293) | alignment | ||
Range on Protein: 36-394
Range on HMM: 18-280/293.0
NYKLLERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSYTNSEhlirregaattsqdiptdpshkeeegscppsqvscpplptlin
..||| . . |..|| ...| | .||.||..|.|||||||.. || .. . .
llkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfp...........................................
gyysfdpkplqghnsikkPHsPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFSYaeginFAEECQSKY-GEETYESFMRCFD
| ..||||.|||| .| |....|||||. ||.....||||||.. .... | .|. || ..| .. ......
..................pe.drlvflGDlvdrGpdslevlelllalkllypdnvvllrGNHElmllnglyg.....fgdetlrkygaaelwdelldwlr
SLPLAAIVENkfgKWLCCHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPlleevlgrrmsdkdyqeFLEIDYLPNpPRGCSCFYGYLAITPFLN
||||||.... |.|..|||. . .|..|....|. ..|| |...|| |||| .| ..||. .||.....|. |. ||.
slplaaligg...kilfvHgGlspdlslldqireinrplriplegllldllwsdp.................dlwsgwlps.yrglgvvfghtavlrflk
NNDLLGIIRAHQCKEEGIGYAYTnnrkelfpfPLVTTLFSASNYCGSYTNKGAILLIYTD
.|.| |||.||. .|. . . . . |.|||.||.| ..|.||.| . ..
kngldliirghqvvpdgylpwfd.........gklvtvfsapnylgrlgnlgavlaldeg
|
|||||||||
PPP_1 | 153-389 | 8.1e-61 | 198.6 | In-house | 52-262 (264) | alignment | |||
Range on Protein: 153-389
Range on HMM: 52-262/264.0
KPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYAeginFAEECQ-SKYGEETYESFMRCFDSLPLAAIVENKFgkwLC
.... .||||||||||| .| |..|.|||||. ||...|.|||||||| .|. |. | .|.. ||..| |. .. .|| |||||....|. |.
pspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvtkv.yg....FkkEvlkkkyskeiyktltdvFdvLplaalideki...li
CHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDplleevlgrrMSDKDYQEFLEIDYLPNPPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEEG
.|||. .....| .|. ..|..| | .|..||| ..| .... .. . . .| .||.....|. ... ||..|.| |||||..||||
vHGGlspeldlldqirkerrktevpeegklcdllekd..........vdillsddkeqeeavansiRGagylfgkdvtekflqknnlkliiRaHevkeeG
igYAYTNNRKelfpfplVTTLFSASNYCGSYTNKGAIL
| ....|| |.|.||||||. . .|.||..
..yeflkkrk.......vvtifsasnyyeegsnrgayv
|
|||||||||
PPP_3 | 152-396 | 3.8e-59 | 192.9 | In-house | 52-263 (271) | alignment | |||
Range on Protein: 152-396
Range on HMM: 52-263/271.0
KKPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYaegiNFAEECQ-SKYGEETYESFMRCFDSLPLAAIVENKFgkwL
..... .||||||||||| .| |..|.|||||. ||.....|||||||| ... | | .|.. .|.|...|. ....|. |||||....|. |
gpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrqinkv.Y....gFkkevlkkkggkkvykklqevFelLplaalidekv...l
CCHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIwsdplleevlgrrmsdkDYQEFLEIDYLPNPPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEE
..|||. ..|||| .|..|||..| | .|...|| .. . . | | .||.....| . . ||..|.| |||||..|||
vvHGGlspsiksldqikklerkievpeegklldll.................lssdpekeeglenskrGagllFgpdvteefleknkLkliiRaHelkee
giGYAYTNNRKelfpfplVTTLFSASNYCGSYTNKGAILLIYTDDI
|| .....| |.|.|||.|||....|.|||| . ...
..Gyeilhdgk.......vvtvfSapnycerasnagailkleealt
|
|||||||||
subfamily_PPP1C_pd | Subfamily PPP1C | 151-393 | 2e-56 | 184.3 | In-house | 59-267 (282) | alignment | ||
Range on Protein: 151-393
Range on HMM: 59-267/282.0
IKKPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYaegiNFAEECQSKYGEETYESFMRCFDSLPLAAIVENKFgkwL
| . .||||||||||| | | |..|||.|. ||...|.||||||| .... | | .||. .|. . ...|. .|. |||||.|..| |
sgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesasinri.y....GfydeckrrysiklWktftdvfnclPlaalvdeki...l
CCHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPllEevlgrrmsdKDYQEFLEidylpNPpRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEE
|.|||. ...||| |....| | | .| |||.|||| . |. ... | | || | .| ... ||..||| |.||||. |.
cvhGGlspelksleqirkiqrPlevpekgllcdllWsdp..d.........kevlgwse.....nd.rGvsftfgkdvvekflqkndldlivrahqvved
giGYAYTNNRKelfpfpLVtTLFSASNYCGSYTNKGAILLIYT
|| . ..|. || |.|||.||||.. |.||.| . .
..Gyeffakrq......lv.tvfsapnycgefdnagavlsvde
|
|||||||||
subfamily_Cele-PPP-Subfam1_pd | Subfamily Cele-PPP-Subfam1 | 37-393 | 8.2e-56 | 182.5 | In-house | 6-303 (317) | alignment | ||
Range on Protein: 37-393
Range on HMM: 6-303/317.0
YKLLERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSYTNSEHLIRRegaattsqdiptdpshkeeegscppS-QVSCPPLPTLIN
.|.... . | | .|| |. |.| ||. ..||||||| ||. .. . . . . . |. .
qdlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwplssqe.........................eksepkslllessk
GYYSFDPKPLQgHNSIKKPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQfSYAeginFAEECQSKYGEETYESFMRCFDS
. . .. | .. ||||||||||| .| | ...|.|||..|| . |.|||||||| . . .| | .|.. .| .. ||.| |
dvkqtvaavks.vnkevtkgykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvnt.qyG....fyrevkkrysaalyeafqlafnv
LPLAAIVENKFgkwLCCHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPlleevlgrrmsD---KDYQEfleidylpnPPRGCSCFYGYLAITPF
|||.|.|..| || |||| .. .| .. |.| . | | .|| |.|| | | |.| .|| . .| |. |
lplcavvnkki...lcmhGGiseelldlkqldklkrpldipdvGvladltwadp...........daevkgyke.........sarGagkvfGakavkef
LNNNDLLGIIRAHQCKEEGigYAYTNNRKelfpfpLVtTLFSASNYCGSYTNKGAILLIYT
|.. || ..|||| |.| | . ..|| || |.||| .||| | .|.| . .
lkkldldlvvrahqvvedG..yeffadrk......lv.tifsapsycGqldniaavlsvdk
|
|||||||||
subfamily_Cele-PPP-1A_pd | Subfamily Cele-PPP-1A | 38-394 | 4.1e-50 | 163.8 | In-house | 6-272 (284) | alignment | ||
Range on Protein: 38-394
Range on HMM: 6-272/284.0
KLLERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSYTNSEHLIRREGAattsqdiptdpshkeeegscppsqvscpplptlingy
|||.. . | | .|| |. | . ||. ..||||||| ||. .. . ..
kllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeake.....................................
ysfdpkplqghnsikkphsPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQfSYaegiNFAEECQSKYGEETYESFMRCFDSLP
||||||||||| .| | |..|.|.|. .| . |.|||||||| . . | | .||. .| | ||.| .| ..|
...................kkylflgdyvdrgpfsievitllfayklllpdkvfllrgnhesrpvnm.qy....gfyleckkrysealyeafqlafnamp
LAAIVENKFgkwLCCHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPlleevlgrrmsDKdyqeflEIDYLPNPPRGCSCFYGYLAITPFLNNND
|.|.|..| .| |||| .. .| .. ||| . | | .|| |.|| .. |... . |||. .| |. ||.. .
lcavvskki...icmhggisedlldlkqldklerpidipdigviadltwadp...........ea......evegykesprgagkvfgakavkeflkkfk
LLGIIRAHQCKEEGigYAYTNNRKelfpfpLVtTLFSASNYCGSYTNKGAILLIYTD
| ..|||| .| | . .|| || |.||| ||| . | .|.| . ..
ldlvvrahqvvmdg..yeffadrk......lv.tifsapsycgqldniaavlnvdee
|
|||||||||
subfamily_PPP5C_pd | Subfamily PPP5C | 157-398 | 1.7e-47 | 155.0 | In-house | 94-301 (322) | alignment | ||
Range on Protein: 157-398
Range on HMM: 94-301/322.0
PSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYaegiNFAEECQSKYGEETYESFMRCFDSLPLAAIVENKFgkwLCCHGGI
.||| ||.|||| .| |.|| ||..|. || .||. |||||| | .. | | .|...|| |. .. | . |..|||| ....|. | .|||.
npylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnkl.y....GfegevkakytekvadlftevfnwlPlahvinekv...lvvhGGl
GSKI-KSLGSIESLERFKEPPLSGPFCDLIWSDPllEEVLGRRMSDkdyqefleidylpnppRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEEGigYA
|. .| . ..|...|| .| ...|.|||| .| || .| || .. .| . ||..|.| |||.|. |||| |
fsedgvtlddlrkidrnaqppeegllvellwsdp..qeanGrspsk................rGvgvqfGpdvtkkflkennleliirshevkeeG..ye
YTNNRKelfpfplVTTLFSASNYCGSYTNKGAILLIYTDDIKV
... | . |.||| ||| . .||||.. . .|| |.
vehdGk.......litvfsapnycdqmgnkgafitlrgddlkl
|
|||||||||
subfamily_PPPLV_pd | Subfamily PPPLV | 158-400 | 2.3e-47 | 154.7 | In-house | 57-284 (290) | alignment | ||
Range on Protein: 158-400
Range on HMM: 57-284/290.0
SYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRcmtqfSYAEGINFAEECQSKYG---EETYESFMRCFDSLPLAAIVENKFgkwLCCHG
|.|||||||||| .| | | .|||||| |||....|||||| . | .| |.. |.. |.| ||..|.|. .|| |||||....| .|.|.
sllflgdyvdrgdfsveliayllalkvlypskvlllrgnhele.....svqesieykgegsfkfgdsleevweafnnvfdalplaavidrkv...fcvha
GIGSKIKSLGSIES----LERFKEPPLSGPF-CDLIWSDPlleeVLGRRMSDKDyQEFLEIDYLPNPPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKE
|| |.. . | . |||.|.. |. |..|||| .| | . . |. ...| || .. .. |. ||..|.| ..|||. ||
gipraimtqayisaiqdilerlkddidgaplaldilwsdp....aedrdlslrg.elvlneGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevke
EGIGYAyTNNRkelfpfplVTTLFSASNYCGSyTNKGAILLIYTDDIKVIK
.|| . .. | . |.||.|.|||| .|. |..|. . ...|.
kGirlq.qkgr........lltvfsssrycGs.sneaalilvdkkklriit
|
|||||||||
subfamily_PPG1_pd | Subfamily PPG1 | 158-395 | 4.6e-47 | 153.7 | In-house | 70-286 (300) | alignment | ||
Range on Protein: 158-395
Range on HMM: 70-286/300.0
SYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQfSYaegiNFAEECQSKY-GE-ETYESFMRCFDSLPLAAIVENKFgkwLCCHGG
||||||||||| || | | .|..||. |||| .|||||||| .|| .| | || || |. .. . || | ||||.... | |||
nylflgdyvdrglysvetisllivlklrypsritllrgnhesrqitq.vy....gfyteclrkyggnsrvwkylteifdylvlaaiideei...ycvhgg
IGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPLLEEVLGRRMSDKDYQEFLEidylpnPPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEEGIGYA
. ...|. | |.||.| | | ..||.|||| .. |.. |.| . .||. || . ||.|||. |||||| ||
lspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqhfvv......sqrgagysygkdvvekflrnndmnriirahqlcnegyqil
YTNnrkelfpfpLVTTLFSASNYCGSYTNKGAILLIYTDD
. | ...|..|| ||| || .|| .| |
fdn.........klstvwsapnycyrcgnkasilelyekd
|
|||||||||
subfamily_PPP6C_pd | Subfamily PPP6C | 156-398 | 8.9e-47 | 152.6 | In-house | 70-277 (290) | alignment | ||
Range on Protein: 156-398
Range on HMM: 70-277/290.0
SpSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYaegiNFAEECQSKYGEE-TYESFMRCFDSLPLAAIVENKFgkwLCCHG
. ||.||||.|||| || | . ||.||. ||.| .|||||||| .|| | | .||..|||. .. ... || |..|||.... || ||
t.syvflgdfvdrgyysletftrlltlkakypdritllrgnhesrqitqv.y....gfydeclnkygnanawkyctkvfdlltiaaiideqv...lcvhG
GIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPllEEVLGRRMSdkdyqefleidylpnpPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEEGIGY
|. ...| | .|. .|| .| | |.||||.|||| |.| .| ||| ..| . |...|.| |.|||| |||. |
glspdvktldqirvieraqeiphkgafcdlvwsdp..edvetwavs................prgagylfgskvtkefvhinnlklicrahqlveeglky
AYTNNrkelfpfplVTTLFSASNYCGSYTNKGAILLIYTDDIKV
. .. . |..|| ||| | .|| . ... .
mfdek.........lvtvwsapnycyrcgnvasilaledaeere
|
|||||||||
subfamily_PPP2C_pd | Subfamily PPP2C | 157-391 | 9.4e-47 | 152.6 | In-house | 72-272 (290) | alignment | ||
Range on Protein: 157-391
Range on HMM: 72-272/290.0
PSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYaegiNFAEECQSKYGEE-TYESFMRCFDSLPLAAIVENKFgkwLCCHGG
||||||||||| || |.. .| |||| |..| .|||||||| .|| | | .|| |||. .. | || |||.|.|... .| |||
tnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhesrqitqv.y....gfydeclrkygnanvwkyftdlfdylpltalvdeqi...fclhgg
IGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPlleevlgrrmsDkDYQEFLEIdylpnpPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEEGIGYA
. .|..| |..|.|..| | ||.|||.|||| | | . . |||. .| | ..|.| |.|||| || ..
lspsidtldkiraldrlqevphegplcdllwsdp...........d.drggwgis......prgagytfgkdisekfnktngltliarahqlvmegynws
YTNNrkelfpfplVTTLFSASNYCGSYTNKGAILLI
. .| |.|.||| ||| |..||| .
hdrn.........vvtifsapnycyrcgnqaailel
|
|||||||||
PPP_4 | 153-348 | 1.2e-46 | 152.3 | In-house | 25-197 (197) | alignment | |||
Range on Protein: 153-348
Range on HMM: 25-197/197.0
KPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFSyaegiNFAEECQSKYGEETYESFMRCFDSLPLAAIVENKFgkwLCC
.... ||.||||||||| .| |..|.|||||. ||.....|||||||. .... .| .|...|.|.|... ....|| |||||....|. |..
pseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnlly.....gfkkevlekhgkeilkklqdvfdllplaalidekv...lvv
HGGIGSKIKSLGSIESLERFKEPP-LSGPFCDL-IWSDPLleevlgrrmsdkDYQEFleidyLPNPPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCK
|||. ....|| .|| .||..| | .. ..|| .|||| . || | | ||.....|. ... ||..|.| |||.|..|
hgglsdelesldkierierkiespleeekrkdlllwsdpr............eaqeg.....lansvrGagllFgpdvtekfleknnlkliirshelk
|
|||||||||
subfamily_PPP4C_pd | Subfamily PPP4C | 157-391 | 1.9e-46 | 151.6 | In-house | 71-271 (288) | alignment | ||
Range on Protein: 157-391
Range on HMM: 71-271/288.0
PSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQfSYaegiNFAEECQSKYGEE-TYESFMRCFDSLPLAAIVENKFgkwLCCHGG
.||||||.|||| || |..|.|||||| || | ..||||||| .|| .| | .|| .|||. .. .. || |.||||...| .| |||
tnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrqitq.vy....gfydeclrkygsanvwryctevfdylslaaiidgki...fcvhgg
IGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPllEEVLGRRMSdkdyqefleidylpnpPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEEGIGYA
. .|..| | |..| .| | .||.|||.|||| |.. | .| ||| ..| ... | ..||. |.|||| || .
lspsistldeirsidrkqevphegplcdllwsdp..edaegwavs................prgagylfgsdvveqfneandielicrahqlvmegyklh
YTNNrkelfpfplVTTLFSASNYCGSYTNKGAILLI
.... | |..|| ||| |. ||| .
fnek.........vltvwsapnycyrcgnvaailel
|
|||||||||
PPP_2 | 152-348 | 4.1e-46 | 150.2 | In-house | 22-198 (198) | alignment | |||
Range on Protein: 152-348
Range on HMM: 22-198/198.0
KKPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYaegiNFAEECQ-SKYGEETYESFMRCFDSLPLAAIVENKFgkwL
..... .||||||||||| .| |..|.|||||. ||.....|||||||. ... | | .|.. .|.|...|. ....|. |||||....|. |
lpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkv.y....gFkkevlkkkggkkvykklqevfelLplaalidekv...l
CCHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPlleevlgrrMSDKDyqefLEIDYLPNPPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCK
..|||. ..||.| .|.. ||..| | .|...|| .. .||.. . . | | ||.....| ... .|..|.| |||||..|
vvHGGlseeiklldqikkeerkiespeegklldlleeek.........lsdpk....ekeellansarGagllfgpdvteelleknklkliiRaHevk
|
|||||||||
subfamily_Cele-PPP-1B_pd | Subfamily Cele-PPP-1B | 45-391 | 1.6e-45 | 148.7 | In-house | 16-320 (339) | alignment | ||
Range on Protein: 45-391
Range on HMM: 16-320/339.0
VQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSyTNSEHLIRREGAATtsQDIPTdpsHKEEEGSCPPSQvscpPLPTLINGYYSFDPkP
. | | .| | .|.| |||.|.||||||| ||. .. | | .| | .|| . | | | |. | | . | |
laelchrareliwsepiflkleapicvmgdihgqfddllamld.mngwplssqefeal..kditv...rsretgkrpqse....phstqpessndvkp.p
LQGHNSIKKPHS---PSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTqFSYAeginFAEECQSKYGEETYESFMRCFDSLPLAAI
. .|..| . ||||||||||| .| | ...| |||.||| | ..|||||||| . || | | . .| . || | |. .|..|.
vaapksvnkevttgykrylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvn.tsyg....fyrevnyrydaqlyecfqnmfnvfpfcav
VENKFgkwLCCHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPlleevlgrRMSDKDYQefleidylPNpPRGCSCFYGYLAITPFLNNNDLLGI
..| .| |||| .. |. . ..| | | | . || |.|| ..| |. | ||.| .| |. ||.. || .
innti...mcmhggisehltsfnqfsvfkrpleipdvgvltdltwadp........dptekgyk........ps.argasfvfgppalraflkkldlqmv
IRAHQCKEEGigYAYTNNRKelfpfplVTTLFSASNYCGSYTNKGAILLI
|| || |.| | . . |. . |.||| |||| | |.. |
irghqvvedg..yeffdgrr.......lvtifsapnycgqndntaavfsi
|
|||||||||
PPP_5_Dcr2 | 154-348 | 2e-45 | 148.2 | In-house | 25-199 (199) | alignment | |||
Range on Protein: 154-348
Range on HMM: 25-199/199.0
PH-SPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRcmtqfSYAEGINFAEECQSK-YGEETYESFMRCFDSLPLAAIVENKFgkwLC
| . .|.||||||||| .| |..|.|||||. ||.....||||||.. . | | .|..|| .|.. |. . ..|| |||||....|. |.
pseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEde.....qlneiygftkevlskyhgkkiykilsdvfdwlPlaalidekv...lv
CHGGIGSKIKSLGSIESLERFKEPP-LSGPFCDLI-WSDPLleevlgrrmsdkD----YqefleidyLPNPPRGCSCFYGYLAITPFLNNNDLLGIIRAH
.|||. ..|||. ..| .||..| | .| .||. |||| | . | ||.....|. .. ||..|.| |||.|
vhgglspeiksiellekierkieipeekgekadlllwsdpr............daqegc........klnseRGagllfgpdvtekfleknnlkliirsh
QCK
..|
elk
|
|||||||||
subfamily_Cele-PPP-Subfam4_pd | Subfamily Cele-PPP-Subfam4 | 153-391 | 9.8e-44 | 142.6 | In-house | 75-280 (298) | alignment | ||
Range on Protein: 153-391
Range on HMM: 75-280/298.0
KPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYaegiNFAEECQSKYG-EETYESFMRCFDSLPLAAIVENKFgkwLC
|.. ||||||||||| .. | |..||| || ||..||.|||||| . . | | |||. .| . |..| |..|||.|.. .. ||
fppdanylflGdyvdrGrqnlevivlllaykvkypnnffllrGnheceainrv.y....Gfyeeckrrykslrlyaefqdvfnalpltaliggri...lc
CHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPlleevlgrrmsDKDYqefleIDYLPNpPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEEG
|||. |.||| .. .|.| .... . ||.|.|| .. .. .| || |. .| .. .|.. |. ..|||| .|
mhGGlskklksldqlrelkrpfdskeeslaidllwadp...........enav.....kgwaen.srGvsvvfGedvvkdllekldidlvvrahqvvqdG
igYAYTNNRKelfpfpLVtTLFSASNYCGSYTNKGAILLI
| . ..| || |.||| .|||...| |.. .
..yeffaekk......lv.tifsaphycgqfdnsaavmkv
|
|||||||||
subfamily_Cele-PPP-Subfam3_pd | Subfamily Cele-PPP-Subfam3 | 148-392 | 4.7e-42 | 136.9 | In-house | 56-269 (287) | alignment | ||
Range on Protein: 148-392
Range on HMM: 56-269/287.0
HNSIKKPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYaegiNFAEECQSKYGEETYESFMRCFDSLPLAAIVENKFg
|.. .. ||||||||||| | | .|.|..||.||| . .|||||| . . . | | || . |..|. |. | |. ||| |.|...
fnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkkinkl.y....Gfkeelkrkrqerlykqfndvfselplcarvskri.
kwLCCHGGIGSKIKSLGSIESLERFKEPPLS--GPFCDLIWSDPlleevlgrrmsDKDYQEFlEidylPNPPRGCSCFYGYLAITPFLNNNDLLGIIRAH
|| |||| |.||| |...|.. . | | ||.|.|| .|| . | | .| |. | .| . .|.. |. |.|||
..lcmhGGispklksldslkalkkpttplacdeglqvdllwadp...........ekdaktf.e....lnkiraisvvfGkkevddllkkldidlivrah
QCKEEGigYAYTNNRKelfpfplVTTLFSASNYCGSYTNKGAILLIY
. .||| ||. ... . |.|||. |.| || ||.. .
evseeG..yaflfdkr.......lvtvfsapyysgedtnlgavvvvs
|
|||||||||
subfamily_Cele-PPP-4C_pd | Subfamily Cele-PPP-4C | 150-391 | 5.9e-39 | 126.9 | In-house | 54-261 (280) | alignment | ||
Range on Protein: 150-391
Range on HMM: 54-261/280.0
SIKKPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMtqfsyAEGINFAEECQSKYGEETYESFMRCFDSLPLAAIVEnkfGKW
. | ||||||||||| . | ||.||| || || .|..|||||| . . | .|.. .| .. |. | .|||||.|.| |.
rvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisi.....nrkygfkdevkrryslalynefqelldslplvalvs...gri
LCCHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPlleevlGRRMSDkdyqefleidyLPNPPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKE
|| |||. |..|| . | | ... . ||.|.|| ... . .||.| .| . . . |. |.| || .
lcmhgglsqklvslddlaelrrpfdsedeclamdllwadp......enkvtg...........waensrgvsvifganvvkdltekldidliarghqvvq
EGigYAYTNNRKelfpfplVTTLFSASNYCGSYTNKGAILLI
.| | . ..| . |.||| .|.|...|. |.| .
dg..yeffadkk.......lvtvfsapkylgefdnsaavliv
|
|||||||||
subfamily_PPZ_pd | Subfamily PPZ | 154-391 | 7.3e-38 | 123.8 | In-house | 77-280 (300) | alignment | ||
Range on Protein: 154-391
Range on HMM: 77-280/300.0
PHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYaegiNFAEECQSKYGEETYESFMRCFDSLPLAAIVEnkfGKWLCCH
| | ||||||||||| | | ||.||. |. || ||.|||||| .|. | | .||. . . ...|. |..||||||| || .| |
ppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecanvtrv.y....gfydeckrrcnikiwktfvdtfntlplaaiva...gkifcvh
GGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPlleevlgrRMSDKDYQEFlEidylpnppRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEEGig
||. ..|. | . | . | | ||.|||| | ..... | || | | .|| |||. . . ||| |.|
gglspvlnsmdeirhvvrptdvpdfglindllwsdp........tdssnewedn.e........rgvsycynkvainkflnkfgfdlvcrahmvvedg..
YAYTNNRKelfpfpLVtTLFSASNYCGSYTNKGAILLI
| . |.| || |.||| |||| . | ||.. .
yeffndrs......lv.tvfsapnycgefdnwgavmsv
|
|||||||||
subfamily_Cele-PPP-5_pd | Subfamily Cele-PPP-5 | 158-395 | 3e-37 | 121.4 | In-house | 73-290 (302) | alignment | ||
Range on Protein: 158-395
Range on HMM: 73-290/302.0
SYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTqFSYAEGINFAEECQSKYGEETYESFMRCFDSLPLAAIVENKFgkwLCCHGGIG
..||||||||| | ||| ...|||| ||... .||||||.... |.|. .. . | | | .| | .| .||||.| .| || ||||
kfvflGdyvdrGsksieciclvfalkvlyptnyillrgnhetkain.faygfreelenrlgkkdgkeiwekfnevfsfmplaalvgeki...lcvhggis
SKIKSLGSIESLERFKEPPLSGPF-CDLIWSDPLLEEVLGRRMSDKdyqefleiDYLPNPPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEEgiGYAY
|..|| .|....| . .. ||...||| ..| . .| | || | . |.. . .. .| |.|||| | |. .
pklesledikkikrplkevtedslaqdllfadpldvqllaavsekP........kyaknivrglsvvfneaavrdvckrlnlklivrahqmiPe..Gfkf
TNNRKelfpfplVTTLFSASNYCGSYTNKGAILLIYTDD
..| . |.|||..| ||||.| . |.
fadkk.......lltifsaprymnesdnkGavlkvdtng
|
|||||||||
subfamily_Cele-PPP-Subfam5_pd | Subfamily Cele-PPP-Subfam5 | 158-395 | 4.1e-37 | 121.0 | In-house | 74-291 (302) | alignment | ||
Range on Protein: 158-395
Range on HMM: 74-291/302.0
SYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTqFSYAEGINFAEECQSKYGEETYESFMRCFDSLPLAAIVENKFgkwLCCHGGIG
..||||||||| | ||| ...|||| ||... .||||||.... |.|. .. . | | | .| | .| .||||.| .| || ||||
kfvflGdyvdrGsksieciclvfalkvlyptnyillrgnhetkain.faygfreelenrlgkkdgkeiwekfnevfsfmplaalvgeki...lcvhggis
SKIKSLGSIESLERFKEPPLSGPF-CDLIWSDPLLEEVLGRRMSDKdyqefleiDYLPNPPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEEgiGYAY
|..|| .|....| . . .. ||...||| ..| . .| | || | . |.. . .. .| |.|||| | |. .
pklesledikkikrplkevtedslaqdllfadpldvqllaavsekP........kyaknivrglsvvfneaavrdvckrlnlklivrahqmiPe..Gfkf
TNNRKelfpfplVTTLFSASNYCGSYTNKGAILLIYTDD
..| . |.|||..| ||||.| . |.
fadkk.......lltifsaprymnesdnkGavlkvdtng
|
|||||||||
subfamily_Cele-PPP-Subfam2_pd | Subfamily Cele-PPP-Subfam2 | 154-391 | 1.9e-35 | 115.5 | In-house | 60-263 (281) | alignment | ||
Range on Protein: 154-391
Range on HMM: 60-263/281.0
PHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYaegiNFAEECQSKYGEETYESFMRCFDSLPLAAIVENKFgkwLCCH
. ..||||||||| | |....|..||..|. | ..|||||| . . | | .||. ||||| . | |||. ||..| .... || |
vpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvnki.y....gfyvecvtkyGeelwalfqrcfnrlpisaliakrv...lcmh
GGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPlleevlgrrmsDKDYQEFLE-IdylpnppRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEEGi
||. .. .| . . ... | ||.|.|| |.. .|. . . || | .| . . .. |||||| .|
GGlsPeltaldelrnrpkpirnldrGlviDllwadp...........dnkveewkass.......rGssftfGknvvddvckrleveliirahqvvqdG.
gYAYTNNRKelfpfplVTTLFSASNYCGSYTNKGAILLI
| . || . |.||. ||| |.| .|.| .
.yevlsgrk.......litvfsvpnycafyknaaavlkv
|
|||||||||
subfamily_Cele-PPP-3B_pd | Subfamily Cele-PPP-3B | 148-392 | 3.3e-35 | 114.5 | In-house | 62-276 (290) | alignment | ||
Range on Protein: 148-392
Range on HMM: 62-276/290.0
HNSIKKPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYaegiNFAEECQSKYGEETYESFMRCFDSLPLAAIVENKFg
... .| .|||||||||| | | |.|. .|. |. . .|||||| | . .. | | || | | . . . |. |.| | |..|
fdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrkvnrl.y....gfkeelarkrgsrlwkqyqdvfaelslcarvgrki.
kwLCCHGGIGSKIKSLGSIESLERFKEPP--LSGPFCDLIWSDPlleevlgrrMSDKDyqEFLEIdylpNPPRGCSCFYGYLAITPFLNNNDLLGIIRAH
|| |||| ||.| |...|.. . | | ||.|.|| ||| . ... | |. | .| .. .|.. | |.|||
..lcmhggisqkiesweslkalkkprvpltcdeglqvdllwadp.........trdkd..dtial....nkqraisvvfgkkglddllkklalslivrah
QCKEEGIGYAYtnNRKelfpfplVTTLFSASNYCGSYTNKGAILLIY
. |||| . . ..| . |.||| |.| || |||. .
evkeegfnflf..dkk.......lvtvfsapyysgndtnlgaiatvs
|
|||||||||
subfamily_Cele-PPP-4A_pd | Subfamily Cele-PPP-4A | 153-392 | 2.7e-34 | 111.9 | In-house | 54-261 (284) | alignment | ||
Range on Protein: 153-392
Range on HMM: 54-261/284.0
KPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYaegiNFAEECQSKYGEE-TYESFMRCFDSLPLAAIVENKFgkwLC
|| ||||||||||| . | ||.|.| || .| .||||||||| . . | | |||| .| . | || | .||.|.| .. ||
fphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinki.y....gfyeecqrrynkpsvyvsfegvfsvmpltalvgqri...lc
CHGGIGSKIKSLGSIESLER-FKEPPLSGPFCDLIWSDPlleevlgrrmsdKDYQEfleiDYLPNpPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEE
|||. .. . . ...| | .| |..|||| ..|. . || || | .| |. .|. .. ..|||| ..
mhggvskmlqnvsqlraikrpfdnpepntlaidilwsdp............tnfqk....gwnpn.srgvsyvfgsdalrklldrlqidlvvrahqvvqd
GigYAYTNNRKelfpfplVTTLFSASNYCGSYTNKGAILLIY
| | . ||. . |.||| ||| . | |.. .
g..yeffanrr.......lvtifsapfycgqfdnaaavmyvn
|
|||||||||
subfamily_Cele-PPP-4B_pd | Subfamily Cele-PPP-4B | 154-391 | 4.1e-33 | 107.9 | In-house | 76-280 (299) | alignment | ||
Range on Protein: 154-391
Range on HMM: 76-280/299.0
PHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYaegiNFAEECQSKYGE-ETYESFMRCFDSLPLAAIVEnkfGKWLCC
| .|||||||||| | | .||. |. || |||||||||| .. . | | |||. .| . | .|. .||. .. .. ||
ppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecpainrv.y....gfyeecnkrykstrlwsifqdafaampltglig...srilcm
HGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDPlleevlgrrmsDKDYqefleIDYLPNpPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEEGi
|||. |...| . | | ..|| ||.|.|| |. .|.|.| || | .| .. ... |. . |||| ..|
hgglspklqtldqlrdltrpqdppnpslgidllwadp...........dqsv.....kdwlan.vrgvsyvfgqdvvadvisrldidlvarahqvvqdg.
gYAYTNNRKelfpfplVTTLFSASNYCGSYTNKGAILLI
| . ..| . |.||| ||| . | ||. .
.yeffaskk.......lvtifsaphycgqfdnsaaimkv
|
|||||||||
subfamily_Cele-PPP-4D_pd | Subfamily Cele-PPP-4D | 154-389 | 3.2e-31 | 101.7 | In-house | 75-279 (297) | alignment | ||
Range on Protein: 154-389
Range on HMM: 75-279/297.0
PHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQfSYaegiNFAEECQSKYGE-ETYESFMRCFDSLPLAAIVENKFgkwLCC
| . ||||||||||| .| | |..||| || .|. .|.|||||| . . | | |||| .| | .| |. |||. .. .| ||
pptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecefvnk.vy....gfyeecqkryqsvrmyaafqdvfnwlpltgliatki...lcm
HGGIGS---KIKSLGSIESLERFKEPpLSGPFCDLIWSDPLleevlgrrmSDkdYQEFLEIDylpnppRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKE
|||. | .| .. .|| .| . .||.|.||. | |.| . ||. | .| |. . .| . |||| .
hgglsplltkeftldtlrkiersteg.kerlvadllwadpi.........sg..lsgfmenq......rgagcgfgrdavlklcsefkldlvcrahqvvq
EGigYAYTNNRKelfpfplVTTLFSASNYCGSYTNKGAIL
.| | . || . |.||| ||| . | |..
dg..yeffagrk.......lvtifsaphycgqfdncaafm
|
|||||||||
subfamily_PPP7C_pd | Subfamily PPP7C | 156-401 | 1.4e-29 | 96.0 | In-house | 92-332 (383) | alignment | ||
Range on Protein: 156-401
Range on HMM: 92-332/383.0
SPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMtQFSYAeginFAEECQSKY---GEETYESFMRCFDSLPLAAIVENKFgkwLCC
. .|.| ||.|||| | | .| |||| ..|| ... ||||| . | | | .||| |.. . . | ||||.....| | .
enpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhil.nlryG....fikeveskykvhgkkilrlledvfawlplatlideki...liv
HGGIgSKIKSLGSIESLERFKEPPL-SGPFCDLIwSDPLLEEVLGRRMSDKDYQEFLEIDY---------LPNPPRGCSCFYGYLAITPFLNNNDLLGII
|||| |.. .| ....|| | . | . . .| ... ..... |.| . || || ...| . .|.. .| .|
hGGi.sdktdlelldkiersklvsvlrpplkege.eaekekeessvkvdkeewrqvldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlklli
RAHQCKEEGigYAYTNNRKelfpfplVTTLFSASNYCGSYTNKGAILLIYTDD-IKVIKY
|.|.|| || | .. ..| | |.|||||| .|.|| . . .| ....|
rsheckpeG..yefvhdkk.......vltifsasnyyeeGsnrGayvklgkdltprivqy
|
|||||||||
subfamily_Cele-PPP-3A_pd | Subfamily Cele-PPP-3A | 157-391 | 1e-28 | 93.7 | In-house | 35-242 (263) | alignment | ||
Range on Protein: 157-391
Range on HMM: 35-242/263.0
PSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQfSYAEGINFAEECQSK-YGEETYESFMRCFDSLPLAAIVENKFgkwLCCHGG
||||||||||| .| | |..|..||.| | ....|||||| ... . | .. . | . | |. | . | .||.||| .. || |||
tqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkaink.nygfhaelkkrfqreevyesvynhfnqvfsymplcaivskri...lcmhgg
IGSKIKSLGSIESLERFKEPPLSGPF-CDLIWSDPlleevlgrrmsDKDYQEFLeidylPNPPRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEegIGY
| ..||| | .. | . |. |||.|.|| .|| . | || | | .| . . . |. |.|||| | ||
isphlkslddiraiplpletakthplacdllwadp...........ekdakgfe.....pnkiraisnvfgkkevddlckrldidlivrahqvve..ygy
AYTNNRKelfpfplVTTLFSASNYCGSYTNKGAILLI
|. .|. . |.|||| | | |....
affadrr.......litvfsasryqielcnyaavvvv
|
|||||||||
Metallophos | Calcineurin-like phosphoesterase | 68-348 | 2.4e-28 | 92.8 | Pfam-A | 2-199 (200) | alignment | ||
Range on Protein: 68-348
Range on HMM: 2-199/200.0
PIVVIGDIHGQFCDLVdifsytnsehlirregaattsqdiptdpshkeeegscppsqvscpplptlingyysfDpKPLQGHNSIKKPHSPSYLFLGDYVD
.|.||||.||.. || | |. .. .... .|||||.||
rilvigDlHgglddle.........................................................d.lllillkiaaeekpdlvlflGDlvd
RGCYSSECILFL--LALKVAYPSRFFMLRGNHESRCMTQFSYAEGINFA-----------------------------EECQSKYGEETYESFMRCFDSL
|| .|||.. | |.||...| ..|.|||||||......... . . ..| ...| . ..|. |
rgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglangeeeyenlkitllttsgelyglsglypllgdsaqeeqleeflal
PLAAIVENKFgkwLCCHGGIGSKIKSLGSIeslerfkepplsgpfcdliwsdplleevlgrrmsdkdyqefleidylpnpprgCSCFYGYLAITPFLNNN
||.|.|..|. |..||...| .| | .|. .|. | ..|...
plralvdgki...lltHgplsssggsgddi.....................................................gselfgpdaleklleky
DLLGIIRAHQCK
.. ..|.|..|
gvdlvlrGHtHk
|
|||||||||
subfamily_Cele-PPP-2B_pd | Subfamily Cele-PPP-2B | 159-391 | 8.5e-28 | 90.6 | In-house | 63-261 (280) | alignment | ||
Range on Protein: 159-391
Range on HMM: 63-261/280.0
YLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQFsYaegiNFAEECQSKYGEETYESFMRCFDSLPLAAIVENKFgkwLCCHGGIGS
.||||||||| | ...|..||. | | ..||||||. .. . | | ||| ||| . | ||. .|..... .. || |||.
lmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnki.y....gfyvecqykygvglwwdfqscfnrmpmsgliskrv...lcmhgglsp
KIKSLGSIESLERFKEPPLSGPFCDLIWSDPlleevlgrrmSDKDYQEFLEIdylpnppRGCSCFYGYLAITPFLNNNDLLGIIRAHQCKEEGigYAYTN
.. | .| . | || | . ||.|||| ..| | | || | ..| . .. .. |||||| ..| |
elinldtirniprpcepldrgllidllwsdp..........tnkgegwfhsi.......rgisymfgkgvveqacksleidliirahqvvqdg..yemma
NRKelfpfplVTTLFSASNYCGSYTNKGAILLI
|. . |.|| ||| .|| |.. .
grr.......litvfsvpnycaqftnaaavvcl
|
|||||||||
subfamily_Cele-PPP-2A_pd | Subfamily Cele-PPP-2A | 153-289 | 2.5e-23 | 75.7 | In-house | 71-202 (307) | alignment | ||
Range on Protein: 153-289
Range on HMM: 71-202/307.0
KPHSPSYLFLGDYVDRGCYSSECILFLLALKVAYPSRFFMLRGNHESRCMTQfSYaegiNFAEECQ---SKYGEETYESFMRCFDSLPLAAIVENKFgkw
.| |.| ||||||| | ||||.|.. |..|| .|||||| . . | | ||| | ||| . | |||. ||..|.. |
rppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnk.ky....gfyeecvtsipkcgeeiwalfqrcfnnlpisaliatki...
LCCHGGIGSKIKSLGSIESLERFKEPPLSGPFCDLIWSDP
|| |||. . | . . |. | |..|.||
lcmhgglspaltcldelrnhpkpirnpfrgivndmlwadp
|
|||||||||
subfamily_Cele-PPP-5_pd | Subfamily Cele-PPP-5 | 40-93 | 1.1e-11 | 37.4 | In-house | 6-59 (302) | alignment | ||
Range on Protein: 40-93
Range on HMM: 6-59/302.0
LERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSYTNSEH
...| . |||. .|.| |.|| ..|.|. ..||||||| ||| |. . .|..
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvske
|
|||||||||
subfamily_Cele-PPP-Subfam5_pd | Subfamily Cele-PPP-Subfam5 | 40-93 | 1.2e-11 | 37.4 | In-house | 7-60 (302) | alignment | ||
Range on Protein: 40-93
Range on HMM: 7-60/302.0
LERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSYTNSEH
...| . |||. .|.| |.|| ..|.|. ..||||||| ||| |. . .|..
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvske
|
|||||||||
subfamily_PPP1C_pd | Subfamily PPP1C | 39-90 | 2.2e-11 | 36.5 | In-house | 9-60 (282) | alignment | ||
Range on Protein: 39-90
Range on HMM: 9-60/282.0
LLERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSYTN
|... .. |...| ...... .||.|.||. ..||||||. ||. .|....
klkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsg
|
|||||||||
subfamily_Cele-PPP-Subfam4_pd | Subfamily Cele-PPP-Subfam4 | 32-88 | 2.8e-11 | 36.0 | In-house | 16-72 (298) | alignment | ||
Range on Protein: 32-88
Range on HMM: 16-72/298.0
QEASNYKLLERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSY
.|.. | .. . |. |||.| |.||. ..|. . ||| | ||||||. ||. .|.
sekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdk
|
|||||||||
PPP_3 | 40-89 | 1.8e-10 | 33.3 | In-house | 2-51 (271) | alignment | |||
Range on Protein: 40-89
Range on HMM: 2-51/271.0
LERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSYT
|. .... |.... .... |..|...|||..|.||||||. ||. .|...
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfkng
|
|||||||||
PPP_1 | 42-89 | 3e-09 | 29.5 | In-house | 3-50 (264) | alignment | |||
Range on Protein: 42-89
Range on HMM: 3-50/264.0
RSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSYT
..... |.... .|.. ||.||..|..| |.||||||| ||. .| ..
eeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvg
|
|||||||||
subfamily_PPP2C_pd | Subfamily PPP2C | 36-87 | 8.4e-09 | 28.0 | In-house | 13-64 (290) | alignment | ||
Range on Protein: 36-87
Range on HMM: 13-64/290.0
NYKLLERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFS
. | || |.|. |.|.| .... |. . ...|. |.||.|||| ||...|
eckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfk
|
|||||||||
subfamily_Cele-PPP-4C_pd | Subfamily Cele-PPP-4C | 42-87 | 1.3e-08 | 27.4 | In-house | 8-53 (280) | alignment | ||
Range on Protein: 42-87
Range on HMM: 8-53/280.0
RSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFS
....||. |... ..|.. . ||. | ||.|||. ||. .|.
eadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfa
|
|||||||||
subfamily_PPP4C_pd | Subfamily PPP4C | 34-89 | 1.6e-08 | 27.2 | In-house | 10-65 (288) | alignment | ||
Range on Protein: 34-89
Range on HMM: 10-65/288.0
ASNYKLLERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSYT
. .|.. ..|. | ..| ... .| . |. .|..| ||||||| ||...| .
lrrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvg
|
|||||||||
subfamily_Cele-PPP-4B_pd | Subfamily Cele-PPP-4B | 43-89 | 2.1e-08 | 26.8 | In-house | 27-73 (299) | alignment | ||
Range on Protein: 43-89
Range on HMM: 27-73/299.0
SSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSYT
.| | . | . | .. .|| . |||.| ||||||. ||. ||. .
qelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdka
|
|||||||||
EF-hand_5 | EF hand | 632-652 | 3.7e-08 | 21.8 | Pfam-A | 4-24 (25) | alignment | ||
Range on Protein: 632-652
Range on HMM: 4-24/25.0
IFQSIDKNNDGQLSMTELQDF
.|. .|||.||..|. ||. .
tFrafDkNgDGkIsreELkrl
|
|||||||||
subfamily_Cele-PPP-Subfam2_pd | Subfamily Cele-PPP-Subfam2 | 44-89 | 7.3e-08 | 25.0 | In-house | 12-57 (281) | alignment | ||
Range on Protein: 44-89
Range on HMM: 12-57/281.0
SVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSYT
.. .| |. .| .|..| . .||||.||.|.|| || .|
eienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfell
|
|||||||||
EF-hand_7 | EF-hand domain pair | 609-652 | 8.5e-08 | 22.2 | Pfam-A | 22-65 (66) | alignment | ||
Range on Protein: 609-652
Range on HMM: 22-65/66.0
LRKHFSQTLLDKVGKQDETQIKLIFQSIDKNNDGQLSMTELQDF
|.... ... .. .. .... ||. ||||.||.||..|. .
LlrllkhlgsplideevrevldyifkeiDkngdGvlsfeEflqa
|
|||||||||
subfamily_Cele-PPP-4D_pd | Subfamily Cele-PPP-4D | 38-87 | 1.2e-07 | 24.3 | In-house | 21-70 (297) | alignment | ||
Range on Protein: 38-87
Range on HMM: 21-70/297.0
KLLERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFS
|.. | |.. | ..|| ..... . ||| | ||||||| ||. .|
kviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfh
|
|||||||||
subfamily_Cele-PPP-2A_pd | Subfamily Cele-PPP-2A | 45-87 | 1.3e-07 | 24.1 | In-house | 25-67 (307) | alignment | ||
Range on Protein: 45-87
Range on HMM: 25-67/307.0
VQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFS
.. .| || .| | .|. . | ||.||.|||| ||...|
fenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfi
|
|||||||||
subfamily_PPP6C_pd | Subfamily PPP6C | 34-88 | 1.4e-07 | 23.9 | In-house | 9-63 (290) | alignment | ||
Range on Protein: 34-88
Range on HMM: 9-63/290.0
ASNYKLLERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSY
|.. | | . .. | . .|. .| .. .|.|. | ||||||| ||...|
akkckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrt
|
|||||||||
subfamily_Cele-PPP-Subfam3_pd | Subfamily Cele-PPP-Subfam3 | 44-87 | 1.9e-07 | 23.3 | In-house | 14-57 (287) | alignment | ||
Range on Protein: 44-87
Range on HMM: 14-57/287.0
SVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFS
. ..|.. .... ..||.. |||...||||||. ||. ||
dilevlekieeileplpalleveapitivGdihGqlddllrifn
|
|||||||||
subfamily_PPG1_pd | Subfamily PPG1 | 38-87 | 5e-07 | 22.2 | In-house | 12-61 (300) | alignment | ||
Range on Protein: 38-87
Range on HMM: 12-61/300.0
KLLERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFS
.|| ..|. |.. .|. .| . .. .|. |.||.|||| |...||
ellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifk
|
|||||||||
EF-hand_1 | EF hand | 629-652 | 5.1e-07 | 18.6 | Pfam-A | 2-25 (29) | alignment | ||
Range on Protein: 629-652
Range on HMM: 2-25/29.0
IKLIFQSIDKNNDGQLSMTELQDF
.| .|. .||..||..| |....
lkeaFkefDkDgdGkIsfeEfkea
|
|||||||||
EF-hand_6 | EF-hand domain | 630-653 | 1.4e-06 | 17.7 | Pfam-A | 3-26 (31) | alignment | ||
Range on Protein: 630-653
Range on HMM: 3-26/31.0
KLIFQSIDKNNDGQLSMTELQDFA
. .|. .||..||... ||...
reaFklfDkdgdGkidaeELrkaL
|
|||||||||
subfamily_Cele-PPP-4A_pd | Subfamily Cele-PPP-4A | 41-89 | 2.3e-06 | 20.2 | In-house | 4-52 (284) | alignment | ||
Range on Protein: 41-89
Range on HMM: 4-52/284.0
ERSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFSYT
|. |. .| ..|. . |. .|| . ||||||| ||. .|
ppedvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkn
|
|||||||||
subfamily_PPZ_pd | Subfamily PPZ | 42-87 | 3.2e-06 | 19.9 | In-house | 27-72 (300) | alignment | ||
Range on Protein: 42-87
Range on HMM: 27-72/300.0
RSSVQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIFS
| . . .| .|| . .|| || .. ..||.|||..||. .|.
nseilqicikarelflaqpallelspsvkivgdvhgqyadllrlft
|
|||||||||
subfamily_Cele-PPP-3B_pd | Subfamily Cele-PPP-3B | 45-86 | 9.4e-06 | 17.8 | In-house | 21-62 (290) | alignment | ||
Range on Protein: 45-86
Range on HMM: 21-62/290.0
VQGLIEEAGKLFKDEETLLRLSAPIVVIGDIHGQFCDLVDIF
. ..|.. .... .||.. ||||..||||||. .|. |
ileilekieeileplpalleveapivivgdihgqldallryf
|