Gene PPP3C-2 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP3C
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP178_AA protein Get Run
AqueP178_AA_108-312 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP3C_pd Subfamily PPP3C 41-515 2.9e-246 810.4 In-house 1-452 (452) alignment 
Range on Protein: 41-515
Range on HMM: 1-452/452.0
RIVSSVSPPKATLLKMADVYDEiTGKPKHEVLKDHFSHEGRLEESVALRIIKGGTDILEKEENMIAVDAPVTVCGDIHGQFFDLMKLFDVGGSPETTRYL
|.|..|. ||.. |....|.|| |||||.||||.|| .||||||..||.||. ....|.||.... |.||.||.|||||||.||.|||.|||.|..|.||
rvvkkvplpkskklteeevfde.tgkpklevlkehflkegrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkyl

FLGDYVDRGYFSIECVLYLWSLKINFPNMVFLLRGNHECRHLTEYFTFKLECKIKYSEAVYEACMNSFDCLPLAALMNGQFLCVHGGLSPEIFTLDDIKN
|||||||||||||||||||..|||..|...||||||||||||||||||| ||||||||.||.|||.|||.||||||.|.||||||||||||| .|||||.
flGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikk

LDRFKEPPAFGPMCDLLWSDPLEDFGQEKpTQEGFSHNSVRGCSYYFSYTACCEFLHNNHLLSIIRAHEAQDSGYKMYRKSQTTGFPALITIFSAPNYLD
|||||||||.||.|||||||||||.|.|| |.| |..||||||||..||.|.||||..|.||||||||||||.||.|||||..||||.|||.||||||||
ldrfkeppasGplcdllWsdPledygeek.teekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyld

VYGNKAAVLKYENNVMNIRQFNAVDHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNLRGgeeDDDMDLEEEESgpIPESSSMALRKEVIKNKIRAVGKM
|| |||||||||||||||||||...|||||||||||||||||||||||||||||.||.     ||... ||||.    |.|... |||||.|||||.||.
vynnkaavlkyennvmnirqfnssphpywlpnfmdvftwslpfvgekvtemlvnilnics...ddelekeeeee..skeesesekrkevirnkiraigkl

ARVFSVLRQEHETVLALKGLTpSGQLPAGVLSQGSEGVqsaleefqvlhaggmRKRVNSFDEARALDRVNERMPP
||||||||.|.|.||.||||| .|.||.|.||.|.||.               .....||.||. ||..||..||
arvfsvlreesesvlllkglt.tgalprgalsegkegl...............eeklssfeeakkldlineklpp
0045823 Metallo-dependent phosphatases 43-486 1.5e-145 478.3 In-house 5-439 (473) alignment 
Range on Protein: 43-486
Range on HMM: 5-439/473.0
VSSVSPPKATLLKMADVYDEItGKPKHEVLKDHFSHEGRLEESVALRIIKGGTDILEKEENMIAVDAPVTVCGDIHGQFFDLMKLFDVGGSPETTRYLFL
...| .| . || .. ..... |.. ...|..|. .||.|.|...|....  ..|| || |.. ......|.||||||..||..|..  | |. .|..||
lklvlipvlrlltlpllfill.glldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvfl

GDYVDRGYFSIECVLYLWSLKINFPNMVFLLRGNHECRHLTEYFTFKLECKIKYSEAVYEACMNSFDCLPLAALMNGQFLCVHGGLSPEIFTLDDIKNLD
||.||||..|.|....|..|||..|. |||||||||.|.|. .. |. |.  ||.| .||.... ...|||||. .|..|.|||||||.. .||.|....
GDlvDrGpdslevlelllalkikypgnvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireie

RFKEPPAFGPMCDLLWSDPlEDFGQEKPTQEGFSHNSVRGCSYYFSYTACCEFLHNNHLLSIIRAHEAQDSGYKMYRKSQTTGFPALITIFSAPNYLDVY
|. |.| .|...||||||| ..  ... ... | .||.||..|.|.. | .|||..|.|  |.|.|.... ||..... ...|.. .||.||||||....
rpleipddgllldllwsdP.weddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrg

GNKAAVLKYENNVMNIRQFNAVDHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNLRGGEEDDDMDLEEeesgpipESSSMALRKEVIKNKIRAVGKMAR
||.||||..........||....||..||.|.|||..||||..||.||.|...||. ...| .. . .        ..  .  ..|...|||.|.||..|
gnlaAvlvidedlisfiqfdpsphplilplfldvfllslpfllekltellllllnivsddellededil.......glllleallellrnkilalgkllr

VFSVLRQEHETVLALKGLTPSGQLPAGVLSQGSEGVQSALEEFQ
||||||.|.|.|| |||||||| || |.|..|.| ....|||  
vfsvlreesesvlllkgltpsgllplgllllgkelllesleeal
PP2Ac_SM00156 84-357 1.4e-102 335.4 In-house 3-262 (271) alignment 
Range on Protein: 84-357
Range on HMM: 3-262/271.0
ESVALRIIKGGTDILEKEENMIAVDAPVTVCGDIHGQFFDLMKLFDVGGSPETTRYLFLGDYVDRGYFSIECVLYLWSLKINFPNMVFLLRGNHECRHLT
.. .|....   .||..|.|.. |.|||||.||||||. ||..|.. .| |....|.|||||||||..|||..|.|..||| .|. |.|||||||.....
keevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssvn

EYFTFKLECKIKYSEAVYEACMNSFDCLPLAALMNGQFLCVHGGLSPEIFTLDDIKNLDRFKEPPAFGPMCDLLWSDPledfgqeKPTQEGFSHNSvRGC
....|. |.|.||.. .|| ... |..||||||.. ..||.|||||||. .||||..|.|.||.|  |...|||||||       . ...||.... ||.
kiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdp.......eqkekgfqpsk.rgl

SYYFSYTACCEFLHNNHLLSIIRAHEAQDSGYKMYRKSqttgfpALITIFSAPNYLDVYGNKAAVLKYENNVMN
|..|.  | .|||..|.|  ||||||..|.||... ..       |.||||||||.| ..|||||||.|.|.. 
svvFgedavkeflkknnlkliiRahevvdeGyeffadk......klvtifsapnycdefsnkaavlkveknlkl
PPP_1 83-350 2.6e-102 334.6 In-house 2-263 (264) alignment 
Range on Protein: 83-350
Range on HMM: 2-263/264.0
EESVALRIIKGGTDILEKEENMIAVDAPVTVCGDIHGQFFDLMKLFDVGGSPETTRYLFLGDYVDRGYFSIECVLYLWSLKINFPNMVFLLRGNHECRHL
||... ...|  ...|.||||.. |....||||||||||.||.||| |||....|.|||||||||||..|.|..|.|..||...|. .||||||||.|..
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

TEYFTFKLECK-IKYSEAVYEACMNSFDCLPLAALMNGQFLCVHGGLSPEIFTLDDIKNLDRFKEPPAFGPMCDLLWSDPLEDFGQeKPTQEGFSHNSVR
|....|| |..  |||. .|......||.||||||.....|.||||||||. .||.|....|..| |. |..||||..|  ... . ...||.. .||.|
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsd.dkeqeeavansiR

GCSYYFSYTACCEFLHNNHLLSIIRAHEAQDSGYKMYRKSQttgfpaLITIFSAPNYLDVYGNKAAVLK
|..|.|.. . ..||..|.| .||||||... ||....|..      ..|||||.|| .. .|..|..|
GagylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrk......vvtifsasnyyeegsnrgayvk
0049330 Metallo-dependent phosphatases 68-370 6.7e-96 314.0 In-house 16-305 (309) alignment 
Range on Protein: 68-370
Range on HMM: 16-305/309.0
KHEVLKDHFSHEGRLEESVALRIIKGGTDILEKEENMIAVDAPVTVCGDIHGQFFDLMKLFDVGGSPETTRYLFLGDYVDRGYFSIECVLYLWSLKINFP
  ..|.... ....|.|...|...   ..|| .| |.. ......|.||||||..||..|..  | |  .|..||||.||||..|.|..|.|..||. .|
lldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkllyp

NMVFLLRGNHECRHLTEYFTFKLECKIKYSEAVYEACMNSFDCLPLAALMNGQFLCVHGGLSPEIFTLDDIKNLDRFKEPPAFGPMCDLLWSDPLEDFGQ
. |||||||||.|.|. .. |. |.. ||.. ..|.... ...|||||. .|..|||||||||.. .||.|..|.|. |.|..|..|||||||||...  
dnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpireg

ekptqegFSHNSvRGCSYYFSYTACCEFLHNNHLLSIIRAHEAQDSGYKMYRKSQttgfpaLITIFSAPNYLDVYGNKAAVLKYENN-VMNIRQFNAVDH
       | .|  ||....| .|| ..||. |.|  |||.|.|...||... . .      |||.||||||....||..|||..... |.....|..|..
.......fapnp.rglgvvfghtaverflkkngldliirghgavfgGyltffdgk......litvfsapnycgrlgnlgavleidedlvisfllfepvpl

PYWL
...|
llll
PPP_3 82-357 3.2e-95 311.2 In-house 2-264 (271) alignment 
Range on Protein: 82-357
Range on HMM: 2-264/271.0
LEESVALRIIKGGTDILEKEENMIAVDAPVTVCGDIHGQFFDLMKLFDVGGSPETTRYLFLGDYVDRGYFSIECVLYLWSLKINFPNMVFLLRGNHECRH
|.|... ...|  ..|||||.|.. ..||||||||||||. ||..||..||....|.|||||||||||..|.|..|.|..|||..|. |.|||||||.|.
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

LTEYFTFKLECK-IKYSEAVYEACMNSFDCLPLAALMNGQFLCVHGGLSPEIFTLDDIKNLDRFKEPPAFGPMCDLLWSDPLedfgqekpTQEGFSHNSV
......|| |..  |... ||..... |..||||||.....|.|||||||.| .||.||.|.|..| |  |...|||.|..         ..|.. .||.
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdp........ekeeglensk

RGCSYYFSYTACCEFLHNNHLLSIIRAHEAQDSGYKMYRKsqttgfPALITIFSAPNYLDVYGNKAAVLKYENNVMN
||....|.  . .|||..|.|  ||||||... ||.....        ..|.||||||.. ..|..|.|| |.. ..
rGagllFgpdvteefleknkLkliiRaHelkeeGyeilhd......gkvvtvfSapnycerasnagailkleealts
0053225 Metallo-dependent phosphatases 69-356 6.3e-89 291.2 In-house 9-283 (293) alignment 
Range on Protein: 69-356
Range on HMM: 9-283/293.0
HEVLKDHFSHEGRLEESVALRIIKGGTDILEKEENMIAVDAPVTVCGDIHGQFFDLMKLFDVGGSPETTRYLFLGDYVDRGYFSIECVLYLWSLKINFPN
...|.... .  .| |...|...   ..|| || |.. ......|.|||||...||..|..  | |...|..||||.||||..|.|....|..||. .|.
ldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllypd

MVFLLRGNHECRHLTEYFTFKLECKIKY-SEAVYEACMNSFDCLPLAALMNGQFLCVHGGLSPEIFTLDDIKNLDRFKEPPAFGPMCDLLWSDPLEDFGQ
 |.|||||||...|. .. |. |.. || .......... ...|||||| .|..|.|||||||.. .||.|....|. ..| .|...||||||| . .| 
nvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpdlwsgw

EKPTqegfshnsvRGCSYYFSYTACCEFLHNNHLLSIIRAHEAQDSGYKMYRKsqttgfPALITIFSAPNYLDVYGNKAAVLKYENN-VM
 .           ||....| .||...||..|.|  |||.|.....||... .      . |.|.|||||||...||..|||..... |.
lpsy.........rglgvvfghtavlrflkkngldliirghqvvpdgylpwfd......gklvtvfsapnylgrlgnlgavlaldeglvw
subfamily_PPP4C_pd Subfamily PPP4C 84-356 2.3e-84 276.1 In-house 18-276 (288) alignment 
Range on Protein: 84-356
Range on HMM: 18-276/288.0
ESVALRIIKGGTDILEKEENMIAVDAPVTVCGDIHGQFFDLMKLFDVGGSPETTRYLFLGDYVDRGYFSIECVLYLWSLKINFPNMVFLLRGNHECRHLT
|.   .. .   .|| .| |.  ||.||||||||||||.||..||.|||. . |.||||||.||||..|.|. | | .||. .|. . |.|||||.|..|
eeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrqit

EYFTFKLECKIKYS-EAVYEACMNSFDCLPLAALMNGQFLCVHGGLSPEIFTLDDIKNLDRFKEPPAFGPMCDLLWSDPLEdfgqekptQEGFShNSVRG
. . |  ||  ||   .|.. |.. || |.|||...|. .||||||||.| |||.|. .|| .| |  ||.|||||||| .        .||..  | ||
qvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdped........aegwa.vsprg

CSYYFSYTACCEFLHNNHLLSIIRAHEAQDSGYKMYRKSQttgfpaLITIFSAPNYLDVYGNKAAVLKYENNVM
  | |   .. .| ..|..  |.|||.    |||.. . .      ..|..|||||    ||.||.|...... 
agylfgsdvveqfneandielicrahqlvmegyklhfnek......vltvwsapnycyrcgnvaaileldeeld
subfamily_PPP2C_pd Subfamily PPP2C 78-362 2.8e-83 272.5 In-house 13-284 (290) alignment 
Range on Protein: 78-362
Range on HMM: 13-284/290.0
HEGRLEESVALRIIKGGTDILEKEENMIAVDAPVTVCGDIHGQFFDLMKLFDVGGSPETTRYLFLGDYVDRGYFSIECVLYLWSLKINFPNMVFLLRGNH
.  .||||   ....   .||.||.|.  | .|||||||.||||.||..|| .||.   | ||||||||||||.|.|.| .| .||. ... . .|||||
eckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnh

ECRHLTEYFTFKLECKIKYSE-AVYEACMNSFDCLPLAALMNGQFLCVHGGLSPEIFTLDDIKNLDRFKEPPAFGPMCDLLWSDPLeDfgqekptQEGFS
| | .|. . |  ||  ||.. .|..   . ||.|||.||...| .|.||||||.| |||.|..|||..| |  ||.||||||||  |       ..|..
esrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpd.d.......rggwg

hNSVRGCSYYFSYTACCEFLHNNHLLSIIRAHEAQDSGYKMYRKSQttgfpaLITIFSAPNYLDVYGNKAAVLKYENNVM-NIRQFN
  | ||. | |  . . .| ..|.|  |.|||.    ||..  . .      ..||||||||    ||.||.|. ....  .. ||.
.isprgagytfgkdisekfnktngltliarahqlvmegynwshdrn......vvtifsapnycyrcgnqaailelddklkysflqfd
subfamily_PPP1C_pd Subfamily PPP1C 84-356 3.4e-83 272.1 In-house 12-270 (282) alignment 
Range on Protein: 84-356
Range on HMM: 12-270/282.0
ESVALRIIKGGTDILEKEENMIAVDAPVTVCGDIHGQFFDLMKLFDVGGSPETTRYLFLGDYVDRGYFSIECVLYLWSLKINFPNMVFLLRGNHECRHLT
|.   ...|   .|| ..  .. ..|||...||||||. ||..||. .|.|....||||||||||| .|.| .. | ..||..|. .||||||||. ...
eaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesasin

EYFTFKLECKIKYSEAVYEACMNSFDCLPLAALMNGQFLCVHGGLSPEIFTLDDIKNLDRFKEPPAFGPMCDLLWSDPleDfgqEKptQEGFSHNSvRGC
... |. ||| .||  .... .. |.|||||||.. . ||||||||||.  |..|... |  | |  | .||||||||  |   ..  ..|.|.|. || 
riyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdp..d...ke..vlgwsend.rGv

SYYFSYTACCEFLHNNHLLSIIRAHEAQDSGYKMYRKSQttgfpaLITIFSAPNYLDVYGNKAAVLKYENNVM
|. |. ..  .||..|.|  |.|||.  . ||... | |      |.|.||||||.. ..|..|||. .....
sftfgkdvvekflqkndldlivrahqvvedGyeffakrq......lvtvfsapnycgefdnagavlsvdeell
subfamily_PPP5C_pd Subfamily PPP5C 68-369 1.1e-79 260.8 In-house 21-314 (322) alignment 
Range on Protein: 68-369
Range on HMM: 21-314/322.0
KHEVLkDHFSHEGRLEESVALRIIKGGTDILEKEENMIAVDAP----VTVCGDIHGQFFDLMKLFDVGGSPE-TTRYLFLGDYVDRGYFSIECVLYLWSL
 .|.| ..| .. .|.. .||.|..  ...|.|.  .. .. .    .||||||||||.||. .|.. |.|  .  ||| ||.|||| ||.|..| |...
vkell.elfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgf

KINFPNMVFLLRGNHECRHLTEYFTFKLECKIKYSEAVYEACMNSFDCLPLAALMNGQFLCVHGGL-SPEIFTLDDIKNLDRFKEPPAFGPMCDLLWSDP
|. .|| .|| |||||  .. . . |. |.| ||.|.|..   ..|. |||| ..| ..| ||||| | .  ||||....||...||  | ...||||||
kllyPnhfflsrGnhesdnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdp

LEDFGQekptqegfsHNSVRGCSYYFSYTACCEFLHNNHLLSIIRAHEAQDSGYKMYRKSQttgfpaLITIFSAPNYLDVYGNKAAVLKY--ENNVMNIR
 |  |.          .| || . .|      .||..|.|  |||.|| ...||.. .. .      |||.|||||| |  |||.|...   ... ....
qeanGr.........spskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGk......litvfsapnycdqmgnkgafitlrgddlklkfk

QFNAVDHPYW
.|.|| ||  
tfeavehpdv
subfamily_PPP6C_pd Subfamily PPP6C 84-365 2.1e-76 249.8 In-house 17-285 (290) alignment 
Range on Protein: 84-365
Range on HMM: 17-285/290.0
ESVALRIIKGGTDILEKEENMIAVDAPVTVCGDIHGQFFDLMKLFDVGGSPETTRYLFLGDYVDRGYFSIECVLYLWSLKINFPNMVFLLRGNHECRHLT
|. . .. .  .|.| .| |. .| .||||||||||||.||..||  ||.   |.|.||||.|||||.|.| . .| .||...|. . |||||||.|..|
endlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesrqit

EYFTFKLECKIKYSEA-VYEACMNSFDCLPLAALMNGQFLCVHGGLSPEIFTLDDIKNLDRFKEPPAFGPMCDLLWSDPlEDFGQekptqegFsHNSVRG
. . |  ||. || .| ..  |.. || |..||....| |||||||||.. |||.|. ..| .| |  |..|||.|||| ||  .       . . | ||
qvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdp.edvet.......w.avsprg

CSYYFSYTACCEFLHNNHLLSIIRAHEAQDSGYKMYRKSQttgfpaLITIFSAPNYLDVYGNKAAVLKYENNV-MNIRQFNAVD
  | |    . ||.|.|.|  |.|||.  . |.| . . .      |.|..|||||    || |..|. |..   . . |.||.
agylfgskvtkefvhinnlklicrahqlveeglkymfdek......lvtvwsapnycyrcgnvasilaledaeereaklfkavp
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 83-356 2.5e-74 243.0 In-house 25-285 (298) alignment 
Range on Protein: 83-356
Range on HMM: 25-285/298.0
EESVALRIIKGGTDILEKEENMIAVDAPVTVCGDIHGQFFDLMKLFDVGGSPETTRYLFLGDYVDRGYFSIECVLYLWSLKINFPNMVFLLRGNHECRHL
.|.   ..|.  ..|..| . .. ||||..||||||||. ||..||| .| |... ||||||||||| ...| .. | . |...|| .||||||||| ..
keedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnffllrGnheceai

TEYFTFKLECKIKY-SEAVYEACMNSFDCLPLAALMNGQFLCVHGGLSPEIFTLDDIKNLDRFKEPPAFGPMCDLLWSDPLEdfgqekpTQEGFSHNSvR
 . . |. ||| .| | ..|..  . |. |||.||. |. ||.|||||... .||....| | ....      ||||.|| .       ...|...|| |
nrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpen.......avkgwaens.r

GCSYYFSYTACCEFLHNNHLLSIIRAHEAQDSGYKMYRKSQttgfpaLITIFSAPNYLDVYGNKAAVLKYENNVM
| |. |   .  ..|.. ..  ..|||     ||... . .      |.||||||.|.. . | |||.| .....
GvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekk......lvtifsaphycgqfdnsaavmkvdeklv
subfamily_PPG1_pd Subfamily PPG1 89-354 3.8e-74 242.6 In-house 21-285 (300) alignment 
Range on Protein: 89-354
Range on HMM: 21-285/300.0
RIIKGGTDILEKEENMIAVDAPVTVCGDIHGQFFDLMKLFDVGGSPETTRYLFLGDYVDRGYFSIECVLYLWSLKINFPNMVFLLRGNHECRHLTEYFTF
 ...   ..| || |.| . .|||| ||.||||.|....|..||    | |||||||||||..|.| .  |  ||. .|  . ||||||| | .|. . |
eltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrqitqvygf

KLECKIKY--SEAVYEACMNSFDCLPLAALMNGQFLCVHGGLSPEIFTLDDIKNLDRFKEPPAFGPMCDLLWSDPLE--DFGQEKPTQEG-FSHNSVRGC
  ||  ||     |..   . || | |||... .  ||||||||.. ..|.|| ||||.| |  | ..||||||| |  .   ..| .|| .  .| ||.
yteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqhfvvsqrga

SYYFSYTACCEFLHNNHLLSIIRAHEAQDSGYKMYRKSQTTgfpaliTIFSAPNYLDVYGNKAAVLKYENN
 | .      .||.||..  |||||.    ||...  .. .      |..|||||    ||||..|. ...
gysygkdvvekflrnndmnriirahqlcnegyqilfdnkls......tvwsapnycyrcgnkasilelyek
PPP_4 111-311 1e-72 237.3 In-house 1-197 (197) alignment 
Range on Protein: 111-311
Range on HMM: 1-197/197.0
VTVCGDIHGQFFDL-MKLFDVGGSPE-TTRYLFLGDYVDRGYFSIECVLYLWSLKINFPNMVFLLRGNHECRHLTEYFTFKLECKIKYSEAVYEACMNSF
|||.||||||..|| .||...|| |. ...|.|||||||||..|.|..|.|..||...|. |.|||||||...|.....|| |.. |... ........|
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvf

DCLPLAALMNGQFLCVHGGLSPEIFTLDDIKNLDRFKEPP-AFGPMCDL-LWSDPLedfgqekPTQEGfSHNSVRGCSYYFSYTACCEFLHNNHLLSIIR
|.||||||.....|.||||||.|. .||.|....|..| |   . ..|| |||||        ..||| ..|||||....|.... ..||..|.| .|||
dllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpr.......eaqeg.lansvrGagllFgpdvtekfleknnlkliir

AHEAQ
.||..
shelk
PPP_2 111-310 3.8e-71 231.9 In-house 1-197 (198) alignment 
Range on Protein: 111-310
Range on HMM: 1-197/198.0
VTVCGDIHGQFFDLMKLFDVGGSPETTRYLFLGDYVDRGYFSIECVLYLWSLKINFPNMVFLLRGNHECRHLTEYFTFKLECK-IKYSEAVYEACMNSFD
||||||.|||. ||..||..|.......|||||||||||..|.|..|.|..||...|. |.|||||||.........|| |..  |....||..... |.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

CLPLAALMNGQFLCVHGGLSPEIFTLDDIKNLDRFKEPPAFGPMCDLLwsdPLEDfGQEKPTQEGFSHNSVRGCSYYFSYTACCEFLHNNHLLSIIRAHE
.||||||.....|.||||||.|| .||.||. .|..| |. |...|||   . |.  ......|.. .||.||....|.  . .|.|..|.|  ||||||
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldll...eeek.lsdpkekeellansarGagllfgpdvteelleknklkliiRaHe

A
.
v
PPP_5_Dcr2 111-310 1.4e-68 223.8 In-house 1-198 (199) alignment 
Range on Protein: 111-310
Range on HMM: 1-198/199.0
VTVCGDIHGQFFDL-MKLFDVGGSPE-TTRYLFLGDYVDRGYFSIECVLYLWSLKINFPNMVFLLRGNHECRHLTEYFTFKLECKIK-YSEAVYEACMNS
||||||.|||..|| ..||. || |. ...|.|||||||||..|.|..|.|..||...|. |.|||||||...|.|...|. |.. | ... .|... ..
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDCLPLAALMNGQFLCVHGGLSPEIFTLDDIKNLDRFKEPP-AFGPMCDL-LWSDPLedfgqekPTQEGFSHNSVRGCSYYFSYTACCEFLHNNHLLSII
||.||||||.....|.||||||||| .........|..| |   | ..|| |||||        ..|||   ||.||....|.... ..||..|.|  ||
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdpr.......daqegcklnseRGagllfgpdvtekfleknnlklii

RAHEA
|.||.
rshel
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 88-354 1.3e-67 220.9 In-house 12-264 (280) alignment 
Range on Protein: 88-354
Range on HMM: 12-264/280.0
LRIIKGGTDILEKEENMIAVDAPVTVCGDIHGQFFDLMKLFDVGGSPETTRYLFLGDYVDRGYFSIECVLYLWSLKINFPNMVFLLRGNHECRHLTEYFT
 |.|.  ..||  .. |. |||||.||||.|||. ||..||.  . |  . ||||||||||| . .| .| | . |. .||  ..||||||. .. . . 
drviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisinrkyg

FKLECKIKYSEAVYEACMNSFDCLPLAALMNGQFLCVHGGLSPEIFTLDDIKNLDRFKEPPAFGPMCDLLWSDPLEDfgqekptQEGFSHNSvRGCSYYF
|| |.| .||.|.|.   . .| |||.||..|. ||.|||||... .|||...| |  ...      ||||.|| ..       . |...|| ||.|. |
fkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenk.......vtgwaens.rgvsvif

SYTACCEFLHNNHLLSIIRAHEAQDSGYKMYRKSQttgfpaLITIFSAPNYLDVYGNKAAVLKYENN
      .. .  ..  |.| |.  . ||... . .      |.|.||||.||. . |.||||. ...
ganvvkdltekldidliarghqvvqdgyeffadkk......lvtvfsapkylgefdnsaavlivder
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 97-356 7.4e-66 215.5 In-house 23-274 (284) alignment 
Range on Protein: 97-356
Range on HMM: 23-274/284.0
ILEKEENMIAVDAPVTVCGDIHGQFFDLMKLFDVGGSP------ETTRYLFLGDYVDRGYFSIECVLYLWSLKINFPNMVFLLRGNHECRHLTEYFTFKL
.. ||.  . ..|||...||||||| ||. |.|. | |      . ..||||||||||| |||| .. |...|. .|. ||||||||| | .   . | |
lfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrgnhesrpvnmqygfyl

ECKIKYSEAVYEACMNSFDCLPLAALMNGQFLCVHGGLSPEIFTLDDIKNLDRFKEPPAFGPMCDLLWSDPLEDFgqekptqEGFsHNSVRGCSYYFSYT
||| .||||.|||   .| ..||.|... . .|.|||.| ... |.....|.|  . |  | ..|| |.|| ..        ||. ..| ||.   |   
eckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaev.......egy.kesprgagkvfgak

ACCEFLHNNHLLSIIRAHEAQDSGYKMYRKSQttgfpaLITIFSAPNYLDVYGNKAAVLKYENNVM
|  |||.. .|  ..|||.    ||...   .      |.|||||| |   . | ||||. .....
avkeflkkfkldlvvrahqvvmdgyeffadrk......lvtifsapsycgqldniaavlnvdeelv
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 84-352 3.9e-65 212.6 In-house 12-269 (287) alignment 
Range on Protein: 84-352
Range on HMM: 12-269/287.0
ESVALRIIKGGTDILEKEENMIAVDAPVTVCGDIHGQFFDLMKLFDVGGSPETTRYLFLGDYVDRGYFSIECVLYLWSLKINFPNMVFLLRGNHECRHLT
..  | ...   .|||  . .. |.||.|..||||||. ||...|.  | .  ..|||||||||||  |.| .|.|.|||| .|. | |||||||.... 
dkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkkin

EYFTFKLECKIKYSEAVYEACMNSFDCLPLAALMNGQFLCVHGGLSPEIFTLDDIKNLDRFKEPPAF--GPMCDLLWSDPLEDfgqekptQEGFSHNSVR
. . || | | |..| .|.   . |. ||| | .. . ||.|||.||.. .||..| | . . | |   | . ||||.|| .|       ...|  | .|
klyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekd.......aktfelnkir

GCSYYFSYTACCEFLHNNHLLSIIRAHEAQDSGYKMYRKSQttgfpaLITIFSAPNYLDVYGNKAAVLKYE
. |  |      ..|..  .  |.|||| .. ||... . .      |.|.|||| |     | .||.. .
aisvvfGkkevddllkkldidlivrahevseeGyaflfdkr......lvtvfsapyysgedtnlgavvvvs
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 89-355 9.5e-63 205.0 In-house 15-267 (281) alignment 
Range on Protein: 89-355
Range on HMM: 15-267/281.0
RIIKGGTDILEKEENMIAVDAPVTVCGDIHGQFFDLMKLFDVGGSPETTRYLFLGDYVDRGYFSIECVLYLWSLKINFPNMVFLLRGNHECRHLTEYFTF
 .|.    |. .|.... .|.|..| ||.|.|| || .||.. | .  ....|||||||||  |.|... |..||| ... ..|||||||  ..   . |
nvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvnkiygf

KLECKIKYSEAVYEACMNSFDCLPLAALMNGQFLCVHGGLSPEIFTLDDIKNLDRFKEPPAFGPMCDLLWSDPledfgqeKPTQEGFSHnSVRGCSYYFS
  ||. || | ..    . |. ||..||.. . ||.|||||||. .||...|  .  ...  | . ||||.||       ..  |.. . |.|| |. | 
yvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadp.......dnkveewka.ssrGssftfG

YTACCEFLHNNHLLSIIRAHEAQDSGYKMYRKSQttgfpaLITIFSAPNYLDVYGNKAAVLKYENNV
     .   .  .  |||||     ||..    .      |||.||.||| . | | ||||| ....
knvvddvckrleveliirahqvvqdGyevlsgrk......litvfsvpnycafyknaaavlkvdetl
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 98-356 1.7e-60 197.8 In-house 40-285 (299) alignment 
Range on Protein: 98-356
Range on HMM: 40-285/299.0
LEKEENMIAVDAPVTVCGDIHGQFFDLMKLFDVGGSPETTRYLFLGDYVDRGYFSIECVLYLWSLKINFPNMVFLLRGNHECRHLTEYFTFKLECKIKYS
. ..  .. |.||. ||||||||. ||...||. | |  . .||||||||||   .| .  |   ||..|.  |.|||||||  .   . |  ||. .| 
fasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecpainrvygfyeecnkryk

-EAVYEACMNSFDCLPLAALMNGQFLCVHGGLSPEIFTLDDIKNLDRFKEPPAFGPMCDLLWSDPLEDFgqekptqEGFSHNsVRGCSYYFSYTACCEFL
   .. .  ..|. .||. |.... ||.||||||.. ||| ...| | ..||.     ||||.|| .          ..  | ||| || |      . .
strlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsv.......kdwlan.vrgvsyvfgqdvvadvi

HNNHLLSIIRAHEAQDSGYKMYRKSQttgfpaLITIFSAPNYLDVYGNKAAVLKYENNVM
..  .  . |||.  . ||... . .      |.|||||| |   . | ||..| ..|..
srldidlvarahqvvqdgyeffaskk......lvtifsaphycgqfdnsaaimkvdenlv
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 84-353 1.2e-59 195.0 In-house 25-283 (297) alignment 
Range on Protein: 84-353
Range on HMM: 25-283/297.0
ESVALRIIKGGTDILEKEENMIAVDAPVTVCGDIHGQFFDLMKLFDVGGSPETTRYLFLGDYVDRGYFSIECVLYLWSLKINFPNMVFLLRGNHECRHLT
|   |...    |.......|. |.||. ||||||||| ||..||  || | |. ||||||||||| |||| .. | . |..||  .|||||||||  . 
eervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecefvn

EYFTFKLECKIKYS-EAVYEACMNSFDCLPLAALMNGQFLCVHGGLSP---EIFTLDDIKNLDRFKEPpAFGPMCDLLWSDPLEDFgqekptqEGFSHNS
. . |  ||. .|    .| |  . |. |||. |.  . ||.||||||   . |||| .....| .|    . ..||||.||.  .        || .| 
kvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisgl.......sgfmenq

vRGCSYYFSYTACCEFLHNNHLLSIIRAHEAQDSGYKMYRKSQttgfpaLITIFSAPNYLDVYGNKAAVLKYEN
 ||.   |   |  .   . .|  . |||.  . ||...   .      |.|||||| |   . | ||..  ..
.rgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrk......lvtifsaphycgqfdncaafmscde
subfamily_PPZ_pd Subfamily PPZ 83-354 1e-58 192.3 In-house 26-283 (300) alignment 
Range on Protein: 83-354
Range on HMM: 26-283/300.0
EESVALRIIKGGTDILEKEENMIAVDAPVTVCGDIHGQFFDLMKLFDVGGSPETTRYLFLGDYVDRGYFSIECVLYLWSLKINFPNMVFLLRGNHECRHL
..|  |.| .   ...  . ... .  .| . ||.|||. ||..||   | | .. |||||||||||  |.| .| |.  ||..|. .|||||||||  .
knseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecanv

TEYFTFKLECKIKYSEAVYEACMNSFDCLPLAALMNGQFLCVHGGLSPEIFTLDDIKNLDRFKEPPAFGPMCDLLWSDPLEDfGQEkptqegFShNSVRG
|  . |  ||| .    .... ...|. |||||.. |. .|||||||| . ..|.|. . |  . | || . ||||||| .   .|      .  .  ||
trvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptds.sne......we.dnerg

CSYYFSYTACCEFLHNNHLLSIIRAHEAQDSGYKMYRKSqttgfpALITIFSAPNYLDVYGNKAAVLKYENN
 || .   |  .|| .  .  . |||   . ||...         .|.|.||||||   . |  ||.   . 
vsycynkvainkflnkfgfdlvcrahmvvedgyeffndr......slvtvfsapnycgefdnwgavmsvseg
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 94-355 1.2e-56 185.2 In-house 15-264 (284) alignment 
Range on Protein: 94-355
Range on HMM: 15-264/284.0
GTDILEKEENMIAVDAPVTVCGDIHGQFFDLMKLFDVGGSPETTRYLFLGDYVDRGYFSIECVLYLWSLKINFPNMVFLLRGNHECRHLTEYFTFKLECK
  .|..|.  .| |..|. .|||||||| ||..|||  | |  . |||||||||||   .| .| |.. |. ||| .|.|||||||  . . . |  ||.
afsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinkiygfyeecq

IKYSE-AVYEACMNSFDCLPLAALMNGQFLCVHGGLSPEIFTLDDIKNLDR-FKEPPAFGPMCDLLWSDPLEdFgqekptQEGFSHNSvRGCSYYFSYTA
 .| . .|| .    |  .||.||.  . ||.|||.|  .  . ... . | | .|       |.||||| . |      |.|.  || || || |   |
rrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptn.f......qkgwnpns.rgvsyvfgsda

CCEFLHNNHLLSIIRAHEAQDSGYKMYRKSQttgfpaLITIFSAPNYLDVYGNKAAVLKYENNV
  ..|   ..  ..|||.  . ||... . .      |.|||||| |   . | |||.  ..|.
lrklldrlqidlvvrahqvvqdgyeffanrr......lvtifsapfycgqfdnaaavmyvnknl
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 137-355 2.5e-56 184.1 In-house 101-305 (317) alignment 
Range on Protein: 137-355
Range on HMM: 101-305/317.0
TRYLFLGDYVDRGYFSIECVLYLWSLKINFPNMVFLLRGNHECRHLTEYFTFKLECKIKYSEAVYEACMNSFDCLPLAALMNGQFLCVHGGLSPEIFTLD
 .||||||||||| |||| |. | .||. .|. ||||||||| | .   . |  |.| .||.|.|||  . | .|||.|..| . ||.|||.| |.. |.
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldlk

DIKNLDRFKEPPAFGPMCDLLWSDPledfgqeKPTQEGFsHNSVRGCSYYFSYTACCEFLHNNHLLSIIRAHEAQDSGYKMYRKSQttgfpaLITIFSAP
 ...|.|  . |  | ..|| |.||       ... .|. ..| || .  |  .|  |||.. .|  ..|||.    ||...   .      |.||||||
qldklkrpldipdvGvladltwadp.......daevkgy.kesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrk......lvtifsap

NYLDVYGNKAAVLKYENNV
.|     | ||||. ....
sycGqldniaavlsvdkkl
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 89-355 2.6e-56 184.1 In-house 13-265 (280) alignment 
Range on Protein: 89-355
Range on HMM: 13-265/280.0
RIIKGGTDILEKEENMIAVDAPVTVCGDIHGQFFDLMKLFDVGGSPETTRYLFLGDYVDRGYFSIECVLYLWSLKINFPNMVFLLRGNHECRHLTEYFTF
 ||.    |. .| |..  .||. | |||| |. |. .|||. |     . .|||||||||   || .. |. ||| . . ..|||||||   . . . |
aiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiygf

KLECKIKYSEAVYEACMNSFDCLPLAALMNGQFLCVHGGLSPEIFTLDDIKNLDRFKEPPAFGPMCDLLWSDPLEdfgqeKptQEGFSHnSVRGCSYYFS
 .||. ||  ...    . |. .|...|.. . ||.|||||||.  || |.|. |  ||   | . ||||||| .     |   ||. | |.|| || | 
yvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptn.....k..gegwfh.sirgisymfg

YTACCEFLHNNHLLSIIRAHEAQDSGYKMYrksqtTGfPALITIFSAPNYLDVYGNKAAVLKYENNV
     .  ..  .  |||||.  . ||.|      .|   |||.|| |||   . | |||.  . |.
kgvveqacksleidliirahqvvqdgyemm.....ag.rrlitvfsvpnycaqftnaaavvclnanl
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 87-356 2.6e-55 180.7 In-house 11-292 (302) alignment 
Range on Protein: 87-356
Range on HMM: 11-292/302.0
ALRIIKGGTDILEKEENMIAVDAPVTVCGDIHGQFFDLMKLFDVGGSPE-----------TTRYLFLGDYVDRGYFSIECVLYLWSLKINFPNMVFLLRG
 | .|.  .. |.||.... . .|||. ||||||| ||....    | |           . ...|||||||||. ||||.  ...||. .|.   ||||
llllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillrg

NHECRHLTEYFTFKLECKIKYSE----AVYEACMNSFDCLPLAALMNGQFLCVHGGLSPEIFTLDDIKNLDRFKEPPAF-GPMCDLLWSDPLEDFGQEKP
|||.. .   ..|. | ......     ..|   . |  .|||||.  . ||||||.|| . .|.|||...|  .  .      |||..|||.  .   .
nhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvqllaav

TQ-EGFSHNSVRGCSYYFSYTACCEFLHNNHLLSIIRAHEAQDSGYKMYRKSQttgfpaLITIFSAPNYLDVYGNKAAVLKYENNV-M
..   . .| ||| |. |  .|  .. ..  |  |.|||     |.|.. . .      |.||||||.|..   || |||| . |  .
sekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkk......lltifsaprymnesdnkGavlkvdtngkl
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 87-355 4.3e-55 180.0 In-house 12-291 (302) alignment 
Range on Protein: 87-355
Range on HMM: 12-291/302.0
ALRIIKGGTDILEKEENMIAVDAPVTVCGDIHGQFFDLMKLFDVGGSPE-----------TTRYLFLGDYVDRGYFSIECVLYLWSLKINFPNMVFLLRG
 | .|.  .. |.||.... . .|||. ||||||| ||....    | |           . ...|||||||||. ||||.  ...||. .|.   ||||
llllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillrg

NHECRHLTEYFTFKLECKIKYSE----AVYEACMNSFDCLPLAALMNGQFLCVHGGLSPEIFTLDDIKNLDRFKEPPAF-GPMCDLLWSDPLEDFGQEKP
|||.. .   ..|. | ......     ..|   . |  .|||||.  . ||||||.|| . .|.|||...|  .  .      |||..|||.  .   .
nhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvqllaav

TQ-EGFSHNSVRGCSYYFSYTACCEFLHNNHLLSIIRAHEAQDSGYKMYRKSQttgfpaLITIFSAPNYLDVYGNKAAVLKYENNV
..   . .| ||| |. |  .|  .. ..  |  |.|||     |.|.. . .      |.||||||.|..   || |||| . | 
sekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkk......lltifsaprymnesdnkGavlkvdtng
subfamily_PPPLV_pd Subfamily PPPLV 92-358 5.6e-55 179.7 In-house 7-282 (290) alignment 
Range on Protein: 92-358
Range on HMM: 7-282/290.0
KGGTDILEKEENMIAVDAPVTVCGDIHGQFFDLM----KLFDVGGSPETTRYLFLGDYVDRGYFSIECVLYLWSLKINFPNMVFLLRGNHECRHLTEYFT
.   ||| .||... ...|. | ||.||.. ||.    .|. .|     . .|||||||||| ||.| . || .||. .|  |.||||||| . ..| ..
dvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqesie

FKLECKIKYS---EAVYEACMNSFDCLPLAALMNGQFLCVHGGLSPEIFTLDDIKN----LDRFKEPPAFGPMC-DLLWSDPLED----FGQEKPTQEGF
.| |.. |.    | |.|| .| || ||||| .. . .|||.|.   | |   |      |.|.|..    |.  |.||||| ||    .  |. ..|||
ykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvlneGf

SHNSVRGCSYYFSYTACCEFLHNNHLLSIIRAHEAQDSGYKMYRKSQttgfpaLITIFSAPNYLDVyGNKAAVLKYENNVMNI
 .|. || .. ||  |   ||..| |  ..||||....|... .|..      |.|.||. .|     |.||..  ... ..|
vdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgr......lltvfsssrycGs.sneaalilvdkkklri
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 84-351 1e-54 178.5 In-house 18-275 (290) alignment 
Range on Protein: 84-351
Range on HMM: 18-275/290.0
ESVALRIIKGGTDILEKEENMIAVDAPVTVCGDIHGQFFDLMKLFDVGGSPETTRYLFLGDYVDRGYFSIECVLYLWSLKINFPNMVFLLRGNHECRHLT
..  | |..   .|||    .. | ||... ||||||. .|.. ||  | |   ..||||||||||  |.|  |.|. .|| ... | |||||||.|.. 
dkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrkvn

EYFTFKLECKIKYSEAVYEACMNSFDCLPLAALMNGQFLCVHGGLSPEIFTLDDIKNLDRFKEPP--AFGPMCDLLWSDPLEDfgqekpTQEGFSHNSVR
  . || |   | .  ..    . |. |.| | .. . ||.|||.|..| . . .| | . . |     | . ||||.|| .|       .. .. |  |
rlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrd......kddtialnkqr

GCSYYFSYTACCEFLHNNHLLSIIRAHEAQDSGYKMYRKSQttgfpaLITIFSAPNYLDVYGNKAAVLKY
. |  |   .  ..|..  |  |.|||| .. |...  . .      |.|.|||| |     |  |... 
aisvvfgkkglddllkklalslivrahevkeegfnflfdkk......lvtvfsapyysgndtnlgaiatv
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 105-351 7.5e-49 159.7 In-house 3-242 (263) alignment 
Range on Protein: 105-351
Range on HMM: 3-242/263.0
IAVDAPVTVCGDIHGQFFDLMKLFDVGGSPETTRYLFLGDYVDRGYFSIECVLYLWSLKINFPNMVFLLRGNHECRHLTEYFTFKLECKIKYS-EAVYEA
. ..||. .||| |||. ||...|.  |.   |.||||||||||| .|.| .. |.|||. .|  ..||||||| . . . . |. | | ..  | |||.
lelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyes

CMNSF----DCLPLAALMNGQFLCVHGGLSPEIFTLDDIKNLDRFKEPPAFGPM-CDLLWSDPLEDfgqekptQEGFSHNSVRGCSYYFSYTACCEFLHN
  | |      .||.|... . ||.|||.|| . .||||. .    |     |. |||||.|| .|        .||  | .|  |  |      .. . 
vynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekd.......akgfepnkiraisnvfgkkevddlckr

NHLLSIIRAHEAQDSGYKMYRKSQttgfpaLITIFSAPNYLDVYGNKAAVLKY
  .  |.|||.  . || ..   .      |||.|||  |     | |||.  
ldidlivrahqvveygyaffadrr......litvfsasryqielcnyaavvvv
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 91-354 3.6e-47 154.0 In-house 29-281 (307) alignment 
Range on Protein: 91-354
Range on HMM: 29-281/307.0
IKGGTDILEKEENMIAVDAPVTVCGDIHGQFFDLMKLFDVGGSPETTRYLFLGDYVDRGYFSIECVLYLWSLKINFPNMVFLLRGNHECRHLTEYFTFKL
|     |.  |  .. .| |. | ||.|||| ||...| . | |  | |.| ||||||| .|.||.| |.. || .|. . |||||||  .. . ..|  
iyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygfye

ECKI---KYSEAVYEACMNSFDCLPLAALMNGQFLCVHGGLSPEIFTLDDIKNLDRFKEPPAFGPMCDLLWSDPledfgqeKPTQEGFsHNSVRGCSYYF
||     |  | ..      |. ||..||.  . ||.|||||| .  ||...|  .    |  | . |.||.||        |.   . . | ||  . |
ecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadp.......dpsvfew.kassrgsgftf

SYTACCEFLHNNHLLSIIRAHEAQDSGYKMYRKSQttgfpaLITIFSAPNYLDVYGNKAAVLKYENN
      .  .   .  |||||.    || .    .      |||||||| | ..| |  .||| .. 
gtnviddvckrlgveliirahqmcfdgywvlsgrk......litifsapmycnfyknagcvlkvdet
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 137-354 7.9e-45 146.4 In-house 120-323 (339) alignment 
Range on Protein: 137-354
Range on HMM: 120-323/339.0
TRYLFLGDYVDRGYFSIECVLYLWSLKINFPNMVFLLRGNHECRHLTEYFTFKLECKIKYSEAVYEACMNSFDCLPLAALMNGQFLCVHGGLSPEIFTLD
 |||||||||||| ||.| |. | .||. .|. ..||||||| | .   . |  | . .|   .||.  | |. .|..|..|   .|.|||.|  . ...
krylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfn

DIKNLDRFKEPPAFGPMCDLLWSDPledfgqeKPTQEGFShNSVRGCSYYFSYTACCEFLHNNHLLSIIRAHEAQDSGYKMYRKSQttgfpaLITIFSAP
..  . |  | |  | . || |.||        ||..|.   | ||.|. |   |   ||..  |  .|| |.  . ||...   .      |.||||||
qfsvfkrpleipdvgvltdltwadp.......dptekgyk.psargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrr......lvtifsap

NYLDVYGNKAAVLKYENN
||     | |||.  ...
nycgqndntaavfsidkk
Metallophos Calcineurin-like phosphoesterase 110-311 1.8e-43 142.2 Pfam-A 2-199 (200) alignment 
Range on Protein: 110-311
Range on HMM: 2-199/200.0
PVTVCGDIHGQFFDL----MKLFDVGGSPETTRYLFLGDYVDRGYFSIECVLYL--WSLKINFPNMVFLLRGNHECRHLTEYFTFKLECK----------
...|.||.||.. ||    ..|........ . .|||||.||||  |.|.  .|  ..||...|. |||||||||........ |.||.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------IKYSEAVYEACMNSFDCLPLAALMNGQFLCVHGGLSPEIFTLDDIknldrfkeppafgpmcdllwsdpledfgqek
                         ..   ..|.. . |..|||.|| .|..|..||.||..  . |||                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

ptqegfshnsvrgCSYYFSYTACCEFLHNNHLLSIIRAHEAQ
             .|..|.. | ...| .. .  ..|.|. .
.............gselfgpdalekllekygvdlvlrGHtHk
subfamily_PPP7C_pd Subfamily PPP7C 72-245 7.2e-31 100.2 In-house 23-203 (383) alignment 
Range on Protein: 72-245
Range on HMM: 23-203/383.0
LKDHFSHEGRLEESVALRIIKGGTDILEKEENMIAVD----APVTVCGDIHGQFFDLMKLFDVGGSPETT-RYLFLGDYVDRGYFSIECVLYLWSLKINF
| ..| .. .|     | |..   ..|.. .|.  |       ||||||.||.. ||. ..   | | .   |.| ||.||||  |.| .| | .| . .
lieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvy

PNMVFLLRGNHECRHLTEYFTFKLECKIKY---SEAVYEACMNSFDCLPLAALMNGQFLCVHGGLSpEIFTLDDIKNLDRFK
|. |.| |||||   |   . |  | . ||   .. . .   . |  ||||.|.. . | ||||.| ..  |. .....| |
pkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGis.dktdlelldkiersk
subfamily_PPP7C_pd Subfamily PPP7C 253-356 1.6e-13 43.1 In-house 237-326 (383) alignment 
Range on Protein: 253-356
Range on HMM: 237-326/383.0
MCDLLWSDPLedfgqekpTQEGFSHNSVRGCSYYFSYTACCEFLHNNHLLSIIRAHEAQDSGYKMYRKSQttgfpaLITIFSAPNYLDVYGNKAAVLKYE
. |.|||||         ..||   |..||   ||      ..|.. .|  .||.|| .  ||..  ...      ..||||| || ..  |. | .|  
vldilwsdpk........akeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkk......vltifsasnyyeeGsnrGayvklg

NNVM
....
kdlt
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 97-136 8.4e-10 31.3 In-house 24-63 (317) alignment 
Range on Protein: 97-136
Range on HMM: 24-63/317.0
ILEKEENMIAVDAPVTVCGDIHGQFFDLMKLFDVGGSPET
.. ||. .. ..||||..||||||| ||. |.|. | | .
lfwkeplkleleapvtivGdihGqfedllalldlnGwpls
subfamily_YNL217W_pd Subfamily YNL217W 111-189 7.9e-07 21.8 In-house 12-83 (235) alignment 
Range on Protein: 111-189
Range on HMM: 12-83/235.0
VTVCGDIHGQFFDLMKLFD--VGGSPETTRYLFLGDYVDRGYFSIECVLYLwslkinFPNMVFLLRGNHECRHLTEYftfK
. | ||.|| . .|..|.|  .||  |    ...|| ...|  |.| | |.        . |  ..||||   | .|   |
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllay...k
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 98-135 3.5e-06 19.4 In-house 27-64 (339) alignment 
Range on Protein: 98-135
Range on HMM: 27-64/339.0
LEKEENMIAVDAPVTVCGDIHGQFFDLMKLFDVGGSPE
.  |  .. ..||. | ||||||| ||. ..|. | | 
iwsepiflkleapicvmgdihgqfddllamldmngwpl