Gene PPP5C-2 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP5C
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP182_AA protein Get Run
AqueP182_AA_183-383 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP5C_pd Subfamily PPP5C 186-383 1.6e-111 365.4 In-house 2-200 (322) alignment 
Range on Protein: 186-383
Range on HMM: 2-200/322.0
VDHSYDGPKLES-DITIDFMKDLLVWFKNQKLLHTKYAYKIILMAKDVFSACPSLVDVTIPDKNKFTICGDIHGQYYDLYNIFELNGIPSMENPYLFNGD
|..||||||||. .||..|.|.|| .||.|| ||.|||.||.|.||......||||..||....|.|.|||||||.|||.|||||||.||.|||||||||
vedsydgpkleeekitkefvkellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGd

FVDRGSFSVEVILTLFGFKVLYPNHFYMSRGNHESITMNQMYGFEGEVKKKYNGKMADLFTEVFNWLPLAHVIDNKVLVMHGGLFSTDDVTLDDLRKID
|||||||||||||||.|||.||||||..|||||||..||..||||||||.||. |.|||||||||||||||||..||||.||||||.|.||||||||||
fvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkid
subfamily_PPP7C_pd Subfamily PPP7C 186-376 2.9e-63 206.9 In-house 2-195 (383) alignment 
Range on Protein: 186-376
Range on HMM: 2-195/383.0
VDHSYDGPKLESDITIDFMKDLLVWFKNQKLLHTKYAYKIILMAKDVFSACPSLVDVTIPDKNKFTICGDIHGQYYDLYNIFELNGIPSMENPYLFNGDF
|..||.||.|.  .| | .. |.  ||..||||.||  .|.  ||.|. . |..  |.    .. |.|||.||.  ||  |.  ||.|| ||||.|||||
vedsytgprlslpltkdeveklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdf

VDRGSFSVEVILTLFGFKVLYPNHFYMSRGNHESITMNQMYGFEGEVKKKY---NGKMADLFTEVFNWLPLAHVIDNKVLVMHGGLFSTDDVTL
||||. |||..| |. . ..||...|. |||||   .|  |||  ||..||   . |.  |. .|| ||||| .||.|.|..|||.  . |..|
vdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdktdlel
PP2Ac_SM00156 218-383 6.1e-61 198.8 In-house 2-161 (271) alignment 
Range on Protein: 218-383
Range on HMM: 2-161/271.0
HTKYAYKIILMAKDVFSACPSLVDVTipdkNKFTICGDIHGQYYDLYNIFELNGiPSMENPYLFNGDFVDRGSFSVEVILTLFGFKVLYPNHFYMSRGNH
.........  .|..... ..||.|.    .. |..||||||..||....||.| .. |..|.|.||.||||..|.||||.|| .|.|||..... ||||
skeevlelleevkeilkqeknlvevs....apvtvvGdihGqlddllrllelag.eppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnH

ESITMNQMYGFEGEVKKKYNGKMADLFTEVFNWLPLAHVIDNKVLVMHGGLFStDDVTLDDLRKID
||  .|..|||| ||| ||. .. . |.|.|..|||| ..|.|.|.||||| . .  .|||.||..
EsssvnkiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlsp.eleslddirklk
PPP_1 224-378 8.2e-60 195.3 In-house 8-158 (264) alignment 
Range on Protein: 224-378
Range on HMM: 8-158/264.0
KIILMAKDVFSAcpslVDVTIPDKNKFTICGDIHGQYYDLyNIFELNGIPSMENPYLFNGDFVDRGSFSVEVILTLFGFKVLYPNHFYMSRGNHESITMN
... ..|....      ....  ... |.|||||||..|| ...  .| || |. |||.||.||||..|||..|.|. .|. ||..... |||||| ...
elkkklkellnk....eenllevseeitvcGDiHGqfdDL.lklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvt

QMYGFEGEVK-KKYNGKMADLFTEVFNWLPLAHVIDNKVLVMHGGLFSTDDVTLDD
..|||. ||. |||. .. ...|.||..|||| .||.|.|..|||| .. |.....
kvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqi
PPP_3 217-380 1.7e-59 194.1 In-house 2-160 (271) alignment 
Range on Protein: 217-380
Range on HMM: 2-160/271.0
LHTKYAYKIILMAKDVFSACPSLVDVTipdkNKFTICGDIHGQYYDLyNIFELNGIPSMENPYLFNGDFVDRGSFSVEVILTLFGFKVLYPNHFYMSRGN
|... ..... ..|....  ..||...    .. |.|||||||..|| .... || || |. |||.||.||||..|.||.|.|. .|..||..... |||
lsenelkelvkklkeilekesnlveis....apvtvcGDiHGqldDL.lelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGn

HESITMNQMYGFEGEVK-KKYNGKMADLFTEVFNWLPLAHVIDNKVLVMHGGLFSTDDvTLDDLR
||| ..|..|||. ||. ||.. |. . ..|||..||||..||.||||.||||... . .||...
hEsrqinkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsik.sldqik
0045823 Metallo-dependent phosphatases 184-382 2.2e-59 194.4 In-house 10-202 (473) alignment 
Range on Protein: 184-382
Range on HMM: 10-202/473.0
MSVDHSYDGPKLESDITIDFMKDLLVWFKNQKLLHTKYAYKIILMAKDVFSACPSLVDVTIpdknKFTICGDIHGQYYDLYNIFELNGIPSMeNPYLFNG
. | .....|.|   ... ... |. ..|...||. ....|.. .||....  |.|....     .....||||||..|| ...|..| |.  . ..|.|
ipvlrlltlpllfillglldldlliehlkkegllpeedllklldeakeilkkepnllelsm....rivviGDiHGqlddLlrllekigfppe.drlvflG

DFVDRGSFSVEVILTLFGFKVLYPNHFYMSRGNHESITMNQMYGFEGEVKKKYNGKMADLFTEVFNWLPLAHVIDNKVLVMHGGLFSTDdVTLDDLRKI
|.||||..|.||.. |. .|..||..... |||||.  .|..||| .|. .||. .. . | |....||||.||..|.|..||||..    .||..|.|
DlvDrGpdslevlelllalkikypgnvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdl.plldqirei
0049330 Metallo-dependent phosphatases 192-382 8.4e-56 182.4 In-house 5-189 (309) alignment 
Range on Protein: 192-382
Range on HMM: 5-189/309.0
GPKLESDITIDFMKDLLVWFKNQKLLHTKYAYKIILMAKDVFSACPSLVDVTipdkNKFTICGDIHGQYYDLYNIFELNGIPSMeNPYLFNGDFVDRGSF
.| |  ........ |. .....|||. .......|.||...   |.|....     .....||||||..|| ...|..| |.  . ..|.||.||||..
dpllllelilslldllielllklkllseeellllllkakeilksepnllels....mrivviGDiHGqlddLlrllekigfppe.drlvflGDlvdrGpd

SVEVILTLFGFKVLYPNHFYMSRGNHESITMNQMYGFEGEVKKKYNGKMADLFTEVFNWLPLAHVIDNKVLVMHGGLFSTDdVTLDDLRKI
|.||.|.|. .|.|||..... |||||.  .|..||| .|.. ||. .. . |......||||.||..|.|..||||..   ..||..|..
slevlllllalkllypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdl.llldqirel
PPP_2 251-375 3.1e-54 176.7 In-house 2-126 (198) alignment 
Range on Protein: 251-375
Range on HMM: 2-126/198.0
TICGDIHGQYYDLyNIFELNGIPSMENPYLFNGDFVDRGSFSVEVILTLFGFKVLYPNHFYMSRGNHESITMNQMYGFEGEVK-KKYNGKMADLFTEVFN
|.|||.|||..|| .|.  || || |. |||.||.||||..|.||.|.|. .|. ||..... |||||| ..|..|||. ||. ||.. |. . ..|||.
tvcGDlHGqldDL.lilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

WLPLAHVIDNKVLVMHGGLFSTDDVT
.||||..||.||||.||||... . .
lLplaalidekvlvvHGGlseeikll
PPP_4 251-382 7.5e-53 172.5 In-house 2-133 (197) alignment 
Range on Protein: 251-382
Range on HMM: 2-133/197.0
TICGDIHGQYYDL-YNIFELNGIPSMENPYLFNGDFVDRGSFSVEVILTLFGFKVLYPNHFYMSRGNHESITMNQMYGFEGEVKKKYNGKMADLFTEVFN
|..||||||..||  ..... | || |. |.|.||.||||..|.||.|.|. .|. ||..... ||||||  .|..|||. ||..|.. .. . ...||.
tvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvfd

WLPLAHVIDNKVLVMHGGLFSTDDvTLDDLRKI
.||||..||.||||.||||... . .||....|
llplaalidekvlvvhgglsdele.sldkieri
PPP_5_Dcr2 251-383 6.2e-52 169.5 In-house 2-135 (199) alignment 
Range on Protein: 251-383
Range on HMM: 2-135/199.0
TICGDIHGQYYDLYNIFELNG-IPSMENPYLFNGDFVDRGSFSVEVILTLFGFKVLYPNHFYMSRGNHESITMNQMYGFEGEVKKKYNGK-MADLFTEVF
|.|||.|||..||  |.. .|  || |. |.|.||.||||..|.||.|.|. .|..||..... |||||.  .|..|||. ||..||.|| . . ...||
tvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdvf

NWLPLAHVIDNKVLVMHGGLFSTDDvTLDDLRKID
.|||||..||.||||.||||... . ....|.||.
dwlPlaalidekvlvvhgglspeik.siellekie
subfamily_PPP1C_pd Subfamily PPP1C 216-382 8.3e-52 169.1 In-house 9-169 (282) alignment 
Range on Protein: 216-382
Range on HMM: 9-169/282.0
LLHTKYAYKIILMAKDVFSACPSLVDVTIPdknkFTICGDIHGQYYDLYNIFELNGIPSMENpYLFNGDFVDRGSFSVEVILTLFGFKVLYPNHFYMSRG
 |...   ... .|.... . | |.... |     .|.|||||||.|| ..|| .|.|. .| ||| ||.||||..|.|.|. |. .|. ||..... ||
klkeaeieallkkareillsqpilleleaP....vkivgdihGqyadllrlfetsgaPpesn.ylflGdyvdrGkqsletivlllaykikypenlfllrG

NHESITMNQMYGFEGEVKKKYNGKMADLFTEVFNWLPLAHVIDNKVLVMHGGLfSTDDVTLDDLRKI
||||  .|..|||  |.|..|. |.   ||.|||.|||| ..|.|.|..|||| |..   |...|||
nhesasinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGl.spelksleqirki
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 211-382 2.7e-51 167.4 In-house 18-184 (298) alignment 
Range on Protein: 211-382
Range on HMM: 18-184/298.0
FKNQKLLHTKYAYKIILMAKDVFSACPSLVDVTIPdknkFTICGDIHGQYYDLYNIFELNGIPSMENpYLFNGDFVDRGSFSVEVILTLFGFKVLYPNHF
 |  | ....   |.| .||..|.. .|||.|  |     ..|||||||| ||  .|. .| |  .| ||| ||.||||....|||. |. .|| |||.|
kkltkvikeedveklielakkifkkqkslvevdap....ikvcGdihGqysdllrlfdkagfppdan.ylflGdyvdrGrqnlevivlllaykvkypnnf

YMSRGNHESITMNQMYGFEGEVKKKY-NGKMADLFTEVFNWLPLAHVIDNKVLVMHGGLfSTDDVTLDDLRKI
.. |||||  ..|..|||  |.|..| . ..   | .|||.|||. .| ...| ||||| |   ..||.||..
fllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGl.skklksldqlrel
0053225 Metallo-dependent phosphatases 199-382 1.2e-50 165.7 In-house 4-182 (293) alignment 
Range on Protein: 199-382
Range on HMM: 4-182/293.0
ITIDFMKDLLVWFKNQKLLHTKYAYKIILMAKDVFSACPSLVDVTipdkNKFTICGDIHGQYYDLYNIFELNGIPSMeNPYLFNGDFVDRGSFSVEVILT
... ... |. .....|||. .......|.||....  |.|....     .....|||||...|| ...|. | |.  . ..|.||.||||..|.||.. 
lilllldllielllllkllseeelllllleakeilkkepnllels....mriyviGDiHGnlddLlallekigfppe.drlvflGDlvdrGpdslevlel

LFGFKVLYPNHFYMSRGNHESITMNQMYGFEGEVKKKY-NGKMADLFTEVFNWLPLAHVIDNKVLVMHGGLfSTDDVTLDDLRKI
|. .|.|||..... |||||.  .|..||| .|.. || . .. | .......||||..|..|.|..|||| | | ..||..|.|
llalkllypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGl.spdlslldqirei
subfamily_PPP3C_pd Subfamily PPP3C 210-383 4.2e-50 163.8 In-house 34-201 (452) alignment 
Range on Protein: 210-383
Range on HMM: 34-201/452.0
WFKNQKLLHTKYAYKIILMAKDVFSACPSLVDVTIPdknkFTICGDIHGQYYDLYNIFELNGIPSmENPYLFNGDFVDRGSFSVEVILTLFGFKVLYPNH
 |...  |... | ||| .| ....  ..|..|  |     |..||||||.||| ..||..| |. .  ||| ||.||||.||.|..| |.  |. ||..
hflkegrleeeaalkiieeaakllkkektlleveaP....itviGdihGqfydllklfevgGdPa.stkylflGdyvdrGyfsiecvlylyalkiaypst

FYMSRGNHESITMNQMYGFEGEVKKKYNGKMADLFTEVFNWLPLAHVIDNKVLVMHGGLfSTDDVTLDDLRKID
... |||||.  . . . |. |.|.||. .. | ..| |. |||| ..... | .|||| |..  .|||..|.|
lfllrGnhecrhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGl.speikslddikkld
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 222-382 1.2e-45 148.8 In-house 11-165 (280) alignment 
Range on Protein: 222-382
Range on HMM: 11-165/280.0
AYKIILMAKDVFSACPSLVDVTIPdknkFTICGDIHGQYYDLYNIFELNGIPSMENpYLFNGDFVDRGSFSVEVILTLFGFKVLYPNHFYMSRGNHESIT
 ...|   |....|  ..|.|  |     ..|||.|||| ||  .|.  ..|  .| ||| ||.||||.. .|||| |. .|| |||.|.. ||||| |.
idrviekckkiltaqatmvevdap....vavcgdlhgqytdllrlfarvsfppdqn.ylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevis

MNQMYGFEGEVKKKYNGKMADLFTEVFNWLPLAHVIDNKVLVMHGGLfSTDDVTLDDLRKI
.|. |||  |||..|. .. . | |... |||. ..  ..|.||||| | . |.||||...
inrkygfkdevkrryslalynefqelldslplvalvsgrilcmhggl.sqklvslddlael
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 213-382 2e-44 145.1 In-house 4-173 (284) alignment 
Range on Protein: 213-382
Range on HMM: 4-173/284.0
NQKLLHTKYAYKIILMAKDVFSACPSLVDVTIPdknkFTICGDIHGQYYDLYNIFELNGIP-----SMENPYLFNGDFVDRGSFSVEVILTLFGFKVLYP
 ||||. |  ... . |...|   .  ... .|     .|.||||||. ||  ...||| |     . |. ||| ||.|||| ||.|||. || .|.|.|
cqkllkekelielcyrarelfwkeklkleieap....vkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllp

NHFYMSRGNHESITMNQMYGFEGEVKKKYNGKMADLFTEVFNWLPLAHVIDNKVLVMHGGLfSTDDVTLDDLRKI
.. .. ||||||  .|. |||  | ||.|  .. . |   || .||. |...|.. ||||. | | . |..| |.
dkvfllrgnhesrpvnmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggi.sedlldlkqldkl
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 218-383 5.3e-44 143.7 In-house 24-187 (297) alignment 
Range on Protein: 218-383
Range on HMM: 24-187/297.0
HTKYAYKIILMAKDVFSACPSLVDVTIPDKnkftICGDIHGQYYDLYNIFELNGIPSMENpYLFNGDFVDRGSFSVEVILTLFGFKVLYPNHFYMSRGNH
  .   |.. .| ||| |  |.|.|  | |    .|||||||. ||  .|   | |   | ||| ||.|||| ||.| |. |. .|| .|  ... ||||
teervlklldlaldvfkaqksmvevnapik....vcgdihgqfpdllrlfhrggwpptan.ylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnh

ESITMNQMYGFEGEVKKKYNG-KMADLFTEVFNWLPLAHVIDNKVLVMHGGLFS--TDDVTLDDLRKID
|   .|..|||  |..|.|.  .|   | .|||||||. .| .|.|.|||||    |...||| ||||.
ecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkie
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 219-382 4.1e-43 140.3 In-house 12-169 (287) alignment 
Range on Protein: 219-382
Range on HMM: 12-169/287.0
TKYAYKIILMAKDVFSACPSLVDVTIPdknkFTICGDIHGQYYDLYNIFELNGIPSmENPYLFNGDFVDRGSFSVEVILTLFGFKVLYPNHFYMSRGNHE
 |  ....  .....   |.|..|. |     ||.||||||. || .||.  | .. .  ||| ||.||||. |.||.| || .|..||.. .. |||||
dkdilevlekieeileplpalleveap....itivGdihGqlddllrifnavGaap.kvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhe

SITMNQMYGFEGEVKKKYNGKMADLFTEVFNWLPLAHVIDNKVLVMHGGLfSTDDVTLDDLRKI
   .|..|||. |.|.|.....   | .||. |||   .....| ||||. | .  .||.|. .
vkkinklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGi.spklksldslkal
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 223-382 6.4e-43 140.1 In-house 30-184 (299) alignment 
Range on Protein: 223-382
Range on HMM: 30-184/299.0
YKIILMAKDVFSACPSLVDVTIPdknkFTICGDIHGQYYDLYNIFELNGIPSMENpYLFNGDFVDRGSFSVEVILTLFGFKVLYPNHFYMSRGNHESITM
 ..  .||.||   .||..|  |      .|||||||| ||  ||. .|.|   | .|| ||.||||   .|.|  |. ||. ||..|.| |||||  ..
qtlcavaksvfasqaslleveap....iivcgdihgqysdllrifdkagfppdvn.flflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecpai

NQMYGFEGEVKKKYNG-KMADLFTEVFNWLPLAHVIDNKVLVMHGGLfSTDDVTLDDLRKI
|..|||  |..|.|.  ..  .| . |...||. .| ...|.||||| |    ||| ||..
nrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhggl.spklqtldqlrdl
subfamily_PPP4C_pd Subfamily PPP4C 248-383 8e-42 136.4 In-house 43-177 (288) alignment 
Range on Protein: 248-383
Range on HMM: 43-177/288.0
NKFTICGDIHGQYYDLYNIFELNGIPsMENPYLFNGDFVDRGSFSVEVILTLFGFKVLYPNHFYMSRGNHESITMNQMYGFEGEVKKKYN-GKMADLFTE
.  |.|||||||.||| ..|...|    |. ||| ||||||| .||| .| |  .|| ||.. .. ||||||  . |.|||  |. .||   ..  . ||
spvtvcgdihgqfydllelfkvggdv.petnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrqitqvygfydeclrkygsanvwrycte

VFNWLPLAHVIDNKVLVMHGGLfSTDDVTLDDLRKID
||..|.|| .||.|....|||| | .  |||..| ||
vfdylslaaiidgkifcvhggl.spsistldeirsid
subfamily_PPP2C_pd Subfamily PPP2C 213-383 1.1e-39 129.3 In-house 13-178 (290) alignment 
Range on Protein: 213-383
Range on HMM: 13-178/290.0
NQKLLHTKYAYKIILMAKDVFSACPSLVDVTIPdknkFTICGDIHGQYYDLYNIFELNGiPSMENPYLFNGDFVDRGSFSVEVILTLFGFKVLYPNHFYM
. | |. .   ... .||...|    . .| .|     |.|||.|||..|| ..| . |  | .  ||| ||.|||| .||| .  |  .|| |..   .
eckqleesevkelcekakeilskesnvqevkcp....vtvcgdvhgqfhdllelfkigg.kspdtnylflgdyvdrgyysvetvtllvalkvrykeriti

SRGNHESITMNQMYGFEGEVKKKY-NGKMADLFTEVFNWLPLAHVIDNKVLVMHGGLfSTDDVTLDDLRKID
 ||||||  . |.||| .|. .|| | ..  .||..|..|||. ..|......|||| |    |||..|..|
lrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhggl.spsidtldkirald
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 224-368 2.1e-39 128.6 In-house 10-150 (284) alignment 
Range on Protein: 224-368
Range on HMM: 10-150/284.0
KIILMAKDVFSACPSLVDVTIPdknkFTICGDIHGQYYDLYNIFELNGIPSMENpYLFNGDFVDRGSFSVEVILTLFGFKVLYPNHFYMSRGNHESITMN
 ... | ..|   | |..|  |      ||||||||. ||  .|. ||.|   | ||| ||.||||   .| || || .||..||||.| |||||   .|
tllfhafsifnkqpmlievnsp....inicgdihgqfsdllrlfdkngfphran.ylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslin

QMYGFEGEVKKKYNGK-MADLFTEVFNWLPLAHVIDNKVLVMHGGL
..|||  |....||   .   |  ||  .||. .. ...|.||||.
kiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggv
subfamily_PPP6C_pd Subfamily PPP6C 245-383 3.2e-39 127.8 In-house 39-176 (290) alignment 
Range on Protein: 245-383
Range on HMM: 39-176/290.0
PDKNKFTICGDIHGQYYDLYNIFELNGI-PsmENPYLFNGDFVDRGSFSVEVILTLFGFKVLYPNHFYMSRGNHESITMNQMYGFEGEVKKKY-NGKMAD
| .   |.|||||||.||| ..|   |  |  .. |.| ||||||| .|.| .  |. .|. ||..  . ||||||  . |.|||  | ..|| |..   
pvsspvtvcgdihgqfydleelfrtggqvp..dtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesrqitqvygfydeclnkygnanawk

LFTEVFNWLPLAHVIDNKVLVMHGGLfSTDDVTLDDLRKID
 .|.||. |..| .||..|| .|||| |.|  |||..| |.
yctkvfdlltiaaiideqvlcvhGgl.spdvktldqirvie
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 217-369 1.7e-38 125.3 In-house 16-163 (290) alignment 
Range on Protein: 217-369
Range on HMM: 16-163/290.0
LHTKYAYKIILMAKDVFSACPSLVDVTIPdknkFTICGDIHGQYYDLYNIFELNGIPSmENPYLFNGDFVDRGSFSVEVILTLFGFKVLYPNHFYMSRGN
.  |  ..|.  .....   |.|..|  |     .| ||||||  .| . |.  | |  .  .|| ||.||||. |.|| | || .|..|... .. |||
fsdkdileilekieeileplpalleveap....ivivgdihgqldallryfdavgypp.kvkflflgdyvdrgakslevslllfcykiryskkvhllrgn

HESITMNQMYGFEGEVKKKYNGKMADLFTEVFNWLPLAHVIDNKVLVMHGGLF
||   .|..|||  |. .| ....   . .||. |.|   ...|.| ||||. 
hevrkvnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggis
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 223-381 5.3e-38 123.8 In-house 14-166 (281) alignment 
Range on Protein: 223-381
Range on HMM: 14-166/281.0
YKIILMAKDVFSACPSLVDVTIPdknkFTICGDIHGQYYDLYNIFELNGIPSmENPYLFNGDFVDRGSFSVEVILTLFGFKVLYPNHFYMSRGNHESITM
 ..| ... .||   .||..  |     .. ||.|.|. || ..||| | .. |. ..| ||.||||  |.||.. || .|. |... .. |||||  ..
envireveaifseekaLveidkP....ivvvGdlhaqfndlkrlfellgrvp.eevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasv

NQMYGFEGEVKKKYNGKMADLFTEVFNWLPLAHVIDNKVLVMHGGLfSTDDVTLDDLRK
|..|||  | . ||  ..  || . || ||..  |...||.||||| | . ..||.||.
nkiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGl.sPeltaldelrn
subfamily_PPZ_pd Subfamily PPZ 220-381 5.8e-38 124.1 In-house 28-183 (300) alignment 
Range on Protein: 220-381
Range on HMM: 28-183/300.0
KYAYKIILMAKDVFSACPSLVDVTIPDKnkftICGDIHGQYYDLYNIFELNGIPSMENpYLFNGDFVDRGSFSVEVILTLFGFKVLYPNHFYMSRGNHES
.   .|   |...| | |.|.... . |    | ||.|||| ||  .|   |.| . | ||| ||.||||  |.| || |. .|. ||. |.. ||||| 
seilqicikarelflaqpallelspsvk....ivgdvhgqyadllrlftkcgfppsan.ylflgdyvdrgkqsletillllcykikypenffllrgnhec

ITMNQMYGFEGEVKKKYNGKMADLFTEVFNWLPLAHVIDNKVLVMHGGLFSTdDVTLDDLRK
  . ..|||  |.|.. | |.   | . || |||| ..  |....||||      ..|..|.
anvtrvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspv.lnsmdeirh
subfamily_PPG1_pd Subfamily PPG1 248-383 5.8e-36 117.3 In-house 41-176 (300) alignment 
Range on Protein: 248-383
Range on HMM: 41-176/300.0
NKFTICGDIHGQYYDLYNIFELNGiPSMENPYLFNGDFVDRGSFSVEVILTLFGFKVLYPNHFYMSRGNHESITMNQMYGFEGEVKKKY--NGKMADLFT
   |. ||.|||.||. .||.. | .  .  ||| ||.|||| .||| |  |  .|. ||    . ||||||  . |.||| .|. .||  | .. . .|
spvtvvgdvhgqfydvleifkigg.qvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrqitqvygfyteclrkyggnsrvwkylt

EVFNWLPLAHVIDNKVLVMHGGLfSTDDVTLDDLRKID
|.|..| || .||... ..|||| | .  ..|... .|
eifdylvlaaiideeiycvhggl.spsvlsidqikvld
Metallophos Calcineurin-like phosphoesterase 249-377 1.9e-35 115.9 Pfam-A 2-169 (200) alignment 
Range on Protein: 249-377
Range on HMM: 2-169/200.0
KFTICGDIHGQYYDL---YNIFELNGIPSMENPYLFNGDFVDRGSFSVEVILTL--FGFKVLYPNHFYMSRGNHESITMNQMYGFEGEVK----------
.....||.||...||    .|.. .. ..  ...||.||.||||  | |..  |  .  |.|.|..... ||||||  .|. |||  |.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------KKYNGKMADLFTEVFNWLPLAHVIDNKVLVMHGGLFSTDDVTLD
                        ...... .. . |.|..|||.. .|.|.|..||.|.|... ..|
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgdd
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 277-382 1.5e-33 109.3 In-house 101-205 (317) alignment 
Range on Protein: 277-382
Range on HMM: 101-205/317.0
NPYLFNGDFVDRGSFSVEVILTLFGFKVLYPNHFYMSRGNHESITMNQMYGFEGEVKKKYNGKMADLFTEVFNWLPLAHVIDNKVLVMHGGLfSTDDVTL
. ||| ||.|||| ||.||.. || .|.|||.. .. |||||| ..|. |||  ||||.|. .. . |  .|| |||. |...|.| ||||. | . . |
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGi.seelldl

DDLRKI
. | |.
kqldkl
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 250-382 3.3e-32 105.2 In-house 9-144 (263) alignment 
Range on Protein: 250-382
Range on HMM: 9-144/263.0
FTICGDIHGQYYDLYNIFELNGIPsMENPYLFNGDFVDRGSFSVEVILTLFGFKVLYPNHFYMSRGNHESITMNQMYGFEGEVKKKYNGK-----MADLF
  |||| |||| ||  ||.  |    .  ||| ||.|||| .|.|||. || .|.  | .... |||||  ..|. |||  |.||... .     . . |
inicgdthgqyndllrifnacgaa.tktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesvynhf

TEVFNWLPLAHVIDNKVLVMHGGLfSTDDVTLDDLRKI
 .||...||. .. ...|.||||. |    .|||.| |
nqvfsymplcaivskrilcmhggi.sphlkslddirai
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 214-381 1.9e-31 102.4 In-house 16-181 (307) alignment 
Range on Protein: 214-381
Range on HMM: 16-181/307.0
QKLLHTKYAY-KIILMAKDVFSACPSLVDVTIPdknkFTICGDIHGQYYDLYNIFELNGIPSmENPYLFNGDFVDRGSFSVEVILTLFGFKVLYPNHFYM
.|. .||  . ..|  |. .||.  .|||.  |      . ||.|||. || |.| | | |  |  |.| ||.|||| .|.|.|| || .|. ||..  .
hkiqytkeefenviyeaqtifssekalvdidpp....cvvvgdlhgqfndlinmfillgrpp.etvyvftgdyvdrgllslecilllftykicypenivl

SRGNHESITMNQMYGFEGEVK---KKYNGKMADLFTEVFNWLPLAHVIDNKVLVMHGGLfSTDDVTLDDLRK
 |||||   .|. |||  |.     |   ..  ||  .|| ||.. .|  |.|.||||| |     ||.||.
lrgnheiarvnkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhggl.spaltcldelrn
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 223-383 5.2e-31 100.9 In-house 12-181 (302) alignment 
Range on Protein: 223-383
Range on HMM: 12-181/302.0
YKIILMAKDVFSACPSLVDVTIPdknkFTICGDIHGQYYDLYNIFELNG----------IPSMENPYLFNGDFVDRGSFSVEVILTLFGFKVLYPNHFYM
...| .  . ..   .|.... |     || ||||||. ||. |.  .           .  ... ..| ||.||||| |.| |  .| .|||||... .
lllieaviellkkektlaeispP....vtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyil

SRGNHESITMNQMYGFEGEVKKKY----NGKMADLFTEVFNWLPLAHVIDNKVLVMHGGLfSTDDVTLDDLRKID
 |||||. ..|  |||..|.....      .. . | ||| ..||| .. .|.| .|||. |    .|.|..||.
lrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggi.spklesledikkik
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 222-383 6.4e-31 100.6 In-house 12-182 (302) alignment 
Range on Protein: 222-383
Range on HMM: 12-182/302.0
AYKIILMAKDVFSACPSLVDVTIPdknkFTICGDIHGQYYDLYNIFELNG----------IPSMENPYLFNGDFVDRGSFSVEVILTLFGFKVLYPNHFY
 ...| .  . ..   .|.... |     || ||||||. ||. |.  .           .  ... ..| ||.||||| |.| |  .| .|||||... 
llllieaviellkkektlaeispP....vtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyi

MSRGNHESITMNQMYGFEGEVKKKY----NGKMADLFTEVFNWLPLAHVIDNKVLVMHGGLfSTDDVTLDDLRKID
. |||||. ..|  |||..|.....      .. . | ||| ..||| .. .|.| .|||. |    .|.|..||.
llrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggi.spklesledikkik
PPP5 PPP5 TPR repeat region 150-242 7.7e-31 96.4 Pfam-A 1-95 (95) alignment 
Range on Protein: 150-242
Range on HMM: 1-95/95.0
KYTECAKIVHQQGFARAIAV-ESEKPVSLTLDLSTMSVDHSYDGPKLE-SDITIDFMKDLLVWFKNQKLLHTKYAYKIILMAKDVFSACPSLVDV
|..|| |.|... | .||.| |....|. ..|.........||||.||  ..|..|.|.|| .||.|| || |..|.|.|  |......||||..
KlkeCeklvkkiaFekAIevdeekrsvaesidiesieieddYdgprledekvtlefvkelleefkkqkklhkkfvyqilldvkellkklpslvei
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 224-382 2e-30 99.2 In-house 13-165 (280) alignment 
Range on Protein: 224-382
Range on HMM: 13-165/280.0
KIILMAKDVFSACPSLVDVTIPDKnkftICGDIHGQYYDLYNIFELNGIPSmENPYLFNGDFVDRGSFSVEVILTLFGFKVLYPNHFYMSRGNHESITMN
 || | . .|     |..   | |    . |||| || |.  .|.| |    |.  .| ||.||||   .||.. || .|. | .. |. |||||. ..|
aiirmveaifmeesnlceaeapik....vigdihaqyqdmnrlfdligrvp.eeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvn

QMYGFEGEVKKKYNGKMADLFTEVFNWLPLAHVIDNKVLVMHGGLfSTDDVTLDDLRKI
..|||  |.. ||   .   |  .|| .|.. .| ..||.||||| | . . || .|.|
kiygfyvecqykygvglwwdfqscfnrmpmsgliskrvlcmhggl.spelinldtirni
subfamily_PPPLV_pd Subfamily PPPLV 250-368 4.6e-27 88.1 In-house 26-150 (290) alignment 
Range on Protein: 250-368
Range on HMM: 26-150/290.0
FTICGDIHGQYYDLYN---IFELNGIPSMENPYLFNGDFVDRGSFSVEVILTLFGFKVLYPNHFYMSRGNHESITMNQMYGFEGEVKKKYNGKMAD---L
  . ||.||.| ||      .   |.  .   .|| ||.|||| ||||.|  |.  ||||| .... |||||  .. . . . || . |.  .. .    
tyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqesieykgegsfkfgdsleevwea

FTEVFNWLPLAHVIDNKVLVMHGGL
|..||..|||| |||.||. .|.|.
fnnvfdalplaavidrkvfcvhagi
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 278-368 6.6e-27 87.5 In-house 121-211 (339) alignment 
Range on Protein: 278-368
Range on HMM: 121-211/339.0
PYLFNGDFVDRGSFSVEVILTLFGFKVLYPNHFYMSRGNHESITMNQMYGFEGEVKKKYNGKMADLFTEVFNWLPLAHVIDNKVLVMHGGL
 ||| ||.|||| ||.||.. |  .|. ||.. |. |||||| ..|  |||  ||. .|. .. . | ..|| .|.. ||.| ...||||.
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggi
TPR_11 TPR repeat 42-108 8.8e-22 66.2 Pfam-A 2-69 (69) alignment 
Range on Protein: 42-108
Range on HMM: 2-69/69.0
KADEWKEIANIKFKEKHFAEAIDCYTKAIEINPSVAVYYGNRSFAHLKLE-NYGFALNDASKALELDK
.|...|| .|  |||. ..|||..|.||.|..|. |..| |.. |.|||  .|  || |..||||||.
nAealkelGnalfkegdydeAieayekAleldpnnaelyynlAlaylklgkdyeeAledyekAleldP
TPR_1 Tetratricopeptide repeat 43-75 1.3e-11 33.4 Pfam-A 1-33 (34) alignment 
Range on Protein: 43-75
Range on HMM: 1-33/34.0
ADEWKEIANIKFKEKHFAEAIDCYTKAIEINPS
|. .. ..|. .| . . ||...| ||.|.||.
akalynlGnaylklgkydeAleyyekALelnPn
TPR_2 Tetratricopeptide repeat 43-75 2.9e-09 26.0 Pfam-A 1-33 (34) alignment 
Range on Protein: 43-75
Range on HMM: 1-33/34.0
ADEWKEIANIKFKEKHFAEAIDCYTKAIEINPS
|. . ..... .| ....||.... ||.|..| 
aealynlGlayyklgdyeeAleafekAleldPn
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 213-276 8.2e-09 28.0 In-house 5-64 (317) alignment 
Range on Protein: 213-276
Range on HMM: 5-64/317.0
NQKLLHTKYAYKIILMAKDVFSACPSLVDVTIPdknkFTICGDIHGQYYDLYNIFELNGIPSME
 |.|...|  ... . |...|   |  ... .|     ||.||||||. ||  ...||| |  .
cqdlfkekelielcyrarelfwkeplkleleap....vtivGdihGqfedllalldlnGwplss
subfamily_YNL217W_pd Subfamily YNL217W 248-358 4.1e-08 26.0 In-house 10-108 (235) alignment 
Range on Protein: 248-358
Range on HMM: 10-108/235.0
NKFTICGDIHGQYYDLYNIFELNGIPSMENPY-LFNGDFVDRGSFSVEVILTLfgfkvlYPNHFYMSRGNHESITMNQMygfegEVKKKYNGKMADLFTE
 .. . ||.|| | .| .... . .   ||   .. ||....|  ||||.  .        .. .  .|||| ... ..     .  || .|     |..
krllvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllay.....kwvkkpkgaeplefss

VFNWLPlaHVID
 |..|.  . ..
kfsfle..skls
TPR_11 TPR repeat 101-137 5.6e-08 22.0 Pfam-A 27-64 (69) alignment 
Range on Protein: 101-137
Range on HMM: 27-64/69.0
SKALELDKTYIKGYYRRASANMALG-KFKLALRDFESV
.||||||. . . ||..| | . || ... ||.|.| .
ekAleldpnnaelyynlAlaylklgkdyeeAledyekA
TPR_12 Tetratricopeptide repeat 47-108 2.4e-07 20.1 Pfam-A 9-77 (78) alignment 
Range on Protein: 47-108
Range on HMM: 9-77/78.0
KEIANIKFKEKHFAEAIDCYTKAIEI-------NPSVAVYYGNRSFAHLKLENYGFALNDASKALELDK
 ..|.. .... . ||...| ||.|.       .| .|... | . ..|.|..|  ||.   ||||...
nnlalvlrrlgdydeAlelyekalellrelgddhpdtaralnnlanlylalgdydeAleylekAleiae
TPR_1 Tetratricopeptide repeat 112-142 2.5e-06 16.6 Pfam-A 2-32 (34) alignment 
Range on Protein: 112-142
Range on HMM: 2-32/34.0
KGYYRRASANMALGKFKLALRDFESVKKSRP
| .|... | . |||.. || ..| . . .|
kalynlGnaylklgkydeAleyyekALelnP
TPR_2 Tetratricopeptide repeat 79-109 6.4e-06 15.6 Pfam-A 3-33 (34) alignment 
Range on Protein: 79-109
Range on HMM: 3-33/34.0
YYGNRSFAHLKLENYGFALNDASKALELDKT
.. |.  |..|| .|  ||..  |||||| .
alynlGlayyklgdyeeAleafekAleldPn