Gene PPPLV in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPPLV
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP185_AA protein Get Run
AqueP185_AA_501-789 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPPLV_pd Subfamily PPPLV 502-791 1e-168 553.0 In-house 1-285 (290) alignment 
Range on Protein: 502-791
Range on HMM: 1-285/290.0
CFLTICSQAVDIFANENRLLPVKSPCYVLGDLHGNFHDLICFEKVLWRMGPILTPASFMFLGDYVDRGDFGFEVISYLFAQKLLMPSKFLLIRGNHEIRS
..|..|..||||.|.|.|||..|||.|||||||||..|||.|||||||.|..|||||..|||||||||||..|.|.||.|.|.|.|||.||.|||||..|
lllslcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnheles

VQESFTYKTECYHKFGESLgEEVWEATNTVFDAMPVAAVIDEKVFCVHGGIPHPSHGGGYISAINDIPNHLPEPAEGSPLAWDIMWNDPirkeDEDNDDS
||||..||.|...|||.|| ||||||.|.||||.|.|||||.||||||.|||.......|||||.||...|.....|.|||.||.|.||    .||.|.|
vqesieykgegsfkfgdsl.eevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdp....aedrdls

LRTELVGNEGFIDNDSRGTGHMFSSDALDSFLRRNNLSHVIRAHEVKETGFQLQQNGRLLTVFSSSHYCGSTNEAACVLVDNKKIRTIRL
||.|||.||||.|||.|||||.||.|||..||.|||||.|.|||||||.|..|||.||||||||||.||||.||||..|||.||.|.|. 
lrgelvlneGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssneaalilvdkkklriitt
0045823 Metallo-dependent phosphatases 502-789 1.1e-75 248.2 In-house 47-319 (473) alignment 
Range on Protein: 502-789
Range on HMM: 47-319/473.0
CFLTICSQAVDIFANENRLLPVKSPCYVLGDLHGNFHDLICfekVLWRMGPILTpASFMFLGDYVDRGDFGFEVISYLFAQKLLMPSKFLLIRGNHEIRS
..| ....| .|...|. ||... ...|.||.||...||.    .| . | .     . ||||.|||| .. ||. .|.| |.. |... |.||||| | 
dllklldeakeilkkepnllelsmrivviGDiHGqlddLlr...llekigfppe.drlvflGDlvDrGpdslevlelllalkikypgnvfllrGNHElrl

VQESFTYKTECYHKFGESlgeeVWEATNTVFDAMPVAAVIDEKVFCVHGGIPhPSHggGYISAINDIPNHLPEPAegSPLAWDIMWNDPiRKEDEDNdds
.   . .. |...|.||.    ..|. . .....|.||||..|...||||.. |..   ... |. |.  |  |   ..|..|..|.||   .| |.   
lnglygfgdetlekyged....lyeeflewlrslPlaaviggkilfvHGGls.pdl..plldqireierpleipd..dgllldllwsdP.weddgdg...

lrtelVGNEGFIDNDSRGTGHMFSSDALDSFLRRNNLSHVIRAHEVKETGFQLQQNGR------LLTVFSSSHYCG-STNEAACVLVDNKKIRTI
       .. |. |. ||.|..|. ||.. ||..|.| ...|.|.. . |..|. .|.      ..||||...|||   | ||....|...|  |
.....llrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedlisfi
PP2Ac_SM00156 502-784 1.1e-72 237.3 In-house 5-258 (271) alignment 
Range on Protein: 502-784
Range on HMM: 5-258/271.0
CFLTICSQAVDIFANENRLLPVKSPCYVLGDLHGNFHDLIcfeKVLWRMGpILTPASFMFLGDYVDRGDFGFEVISYLFAQKLLMPSKFLLIRGNHEIRS
..|...... .|. .|. |. |..|..| ||.||...||.   ..| . |   .   ..||||||||| .. |||..||| |.| |.|. | ||||| .|
evlelleevkeilkqeknlvevsapvtvvGdihGqlddll...rllelag.eppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsss

VQESFTYKTECYHKFgeslGEEVWEATNTVFDAMPVAAVIDEKVFCVHGGIPHPSHGGGYISAINDipnhlPEPAEGSPLAWDIMWNDPirkededndds
|.. .. . |. .|     |.|..|  ...|...|.||..|.|..|.|||..  ..    |. ..      ..  . ..|..|..|.||           
vnkiygfeeevkrky....gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkr.....vkekpeegllidllwsdp...........

lrteLVGNEGFIDNDsRGTGHMFSSDALDSFLRRNNLSHVIRAHEVKETGFQLQQNGRLLTVFSSSHYCGSTNEAACVLVDNK
       ..||  .  ||....|..||.. ||..|||...||||||.. |... ....|.|.||...||.... .|.||  .|
....eqkekgfqpsk.rglsvvFgedavkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkvek
PPP_3 503-783 1.9e-68 223.4 In-house 7-259 (271) alignment 
Range on Protein: 503-783
Range on HMM: 7-259/271.0
FLTICSQAVDIFANENRLLPVKSPCYVLGDLHGNFHDLICFEKvlwrMGPILTPASFMFLGDYVDRGDFGFEVISYLFAQKLLMPSKFLLIRGNHEIRSV
. ...... .|. .|. |. ...|  |.||.|| ..||. ..|    .|      ...||||||||| ...||. .|.| |...|... |.||||| |..
lkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfk....nggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrqi

QESFTYKTECYHKFGeslGEEVWEATNTVFDAMPVAAVIDEKVFCVHGGIPHPSHgggYISAINDIPNHLPEPAEGSPLAWDimwndpirkedednddsl
 . ...|.|. .| |   |..|... . ||...|.||.|||||..||||. .  .    .. |. . ..   | ||. |                     
nkvYgFkkevlkkkg...gkkvykklqevFelLplaalidekvlvvHGGlspsik...sldqikklerkievpeegklldll..................

RTELVGNEGFIDNDSRGTGHMFSSDALDSFLRRNNLSHVIRAHEVKETGFQLQQNGRLLTVFSSSHYCGSTNEAACVLVDN
  .   .|... |..||.| .|..|. ..||..|.|. .|||||.|| |......|...|||| ..||.....|...|  .
lssdpekeeglenskrGagllFgpdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkle
0049330 Metallo-dependent phosphatases 503-785 1.1e-67 221.5 In-house 35-288 (309) alignment 
Range on Protein: 503-785
Range on HMM: 35-288/309.0
FLTICSQAVDIFANENRLLPVKSPCYVLGDLHGNFHDLICfekVLWRMGPIlTPASFMFLGDYVDRGDFGFEVISYLFAQKLLMPSKFLLIRGNHEIRSV
.|... .|..|. .|. ||... ...| ||.||...||.    .| ..| .  .  . ||||.|||| .. ||. .|.| |||.|... |.||||| | .
llllllkakeilksepnllelsmrivviGDiHGqlddLlr...llekigfp.pedrlvflGDlvdrGpdslevlllllalkllypdnvfllrGNHElrll

QESFTYKTECYHKFGeslgEEVWEATNTVFDAMPVAAVIDEKVFCVHGGIpHPSHggGYISAINDIPNHLPEPAEgsPLAWDIMWNDPIRKEDEdnddsl
.  . .. |...|.|    .|.||. . .....|.||||..|..|||||. .|..   ... |... ..|  |..  .| .|..|.||..  ..      
nglygfgdetlrkyg....aelweefldwlrslplaaviggkilcvHgGl.spdl..llldqirelerpleipld..gllcdllwsdplpireg......

rtelvgnegFIDNDsRGTGHMFSSDALDSFLRRNNLSHVIRAHEVKETGFQLQQNGRLLTVFSSSHYCGSTNEAACVLVDNKK
         | .|. || |. |  .|...||..|.|...||.|.. ..|..   .|.|.||||...||| .. ...||. ...
.........fapnp.rglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleided
PPP_1 504-778 9.1e-65 211.5 In-house 7-260 (264) alignment 
Range on Protein: 504-778
Range on HMM: 7-260/264.0
LTICSQAVDIFANENRLLPVKSPCYVLGDLHGNFHDLICfekvLWRMGPILTPASFMFLGDYVDRGDFGFEVISYLFAQKLLMPSKFLLIRGNHEIRSVQ
 .......... .|. || |...  | ||.||.|.||.     | ..|      ...||||||||| . .|.. .|.| ||  |... |.||||| |.| 
aelkkklkellnkeenllevseeitvcGDiHGqfdDLlk....lfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvt

ESFTYKTECYhkfGESLGEEVWEATNTVFDAMPVAAVIDEKVFCVHGGIPHPSHgggYISAINDIPNHLPEPAEGSplAWDIMWNDpirkedednDDSLR
. ...|.|.     .  ..|....   ||| .|.||.||||...||||.    .    .  |. . ..   |.||   . | ...|          | | 
kvygFkkEvl...kkkyskeiyktltdvFdvLplaalidekilivHGGlspeld...lldqirkerrktevpeegk..lcdllekd.........vdill

TELVGNEGFIDNDSRGTGHMFSSDALDSFLRRNNLSHVIRAHEVKETGFQLQQNGRLLTVFSSSHYCGSTNEAAC
..   .|....|  ||.|..|..|. ..||..|||. .|||||||| |... ......|.||.| |. ...... 
sddkeqeeavansiRGagylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrga
subfamily_PPP3C_pd Subfamily PPP3C 504-788 9.2e-64 208.9 In-house 47-316 (452) alignment 
Range on Protein: 504-788
Range on HMM: 47-316/452.0
LTICSQAVDIFANENRLLPVKSPCYVLGDLHGNFHDLICFEKvlwrMGPILTPASFMFLGDYVDRGDFGFEVISYLFAQKLLMPSKFLLIRGNHEIRSVQ
| | ..| ... .|. || |..|  |.||.|| |.||. . .    .|   . ....||||||||| | .|.. ||.| |.  ||.. |.||||| | . 
lkiieeaakllkkektlleveaPitviGdihGqfydllklfe....vgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrhlt

ESFTYKTECYHKFGeslgEEVWEATNTVFDAMPVAAVIDEKVFCVHGGIPHPSHGggyISAINDIpNHLPEPAEGSPLAwDIMWNDPIrkededndDSLR
| ||.|.|| .|..    |||..|    ||..|.||..... .|||||.    .    .  |... . . || .  ||  |..| ||.        .   
eyftfkeeckikys....eevydacmesfdslPlaallnqqflcvhGGlspeiks...lddikkl.drfkeppasGplc.dllWsdPl........edyg

TELvGNEGFIDNDSRGTGHMFSSDALDSFLRRNNLSHVIRAHEVKETGFQLQQN------GRLLTVFSSSHYCGSTNE-AACVLVDNKKIRT
 |  ..| |  |. ||  ...|  |  .||..|.|  .|||||....|.. ...        |.|.||.. |... |. || . ..|.... 
eek.teekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennvmni
0053225 Metallo-dependent phosphatases 503-784 2.7e-62 203.9 In-house 27-279 (293) alignment 
Range on Protein: 503-784
Range on HMM: 27-279/293.0
FLTICSQAVDIFANENRLLPVKSPCYVLGDLHGNFHDLICfekVLWRMGPIlTPASFMFLGDYVDRGDFGFEVISYLFAQKLLMPSKFLLIRGNHEIRSV
.|... .| .|. .|. ||... ..||.||.|||..||.    .| ..| .  .  . ||||.|||| .. ||. .|.| ||| |... |.||||| . .
lllllleakeilkkepnllelsmriyviGDiHGnlddLla...llekigfp.pedrlvflGDlvdrGpdslevlelllalkllypdnvvllrGNHElmll

QESFTYKTECYHKFGeslGEEVWEATNTVFDAMPVAAVIDEKVFCVHGGIPHPSHgggYISAINDIPNHLPEPAEGspLAWDIMWNDPIRKEDEDNDDsl
.  . .. |...|.|   ..|.|.. . .....|.||.|..|...||||...  .   ... |..|  .| .| ||  | .|..|.|| . ..   .   
nglygfgdetlrkyg...aaelwdelldwlrslplaaliggkilfvHgGlspdls...lldqireinrplripleg..llldllwsdpdlwsgwlpsy..

rtelvgnegfidndsRGTGHMFSSDALDSFLRRNNLSHVIRAHEVKETGFQLQQNGRLLTVFSSSHYCGSTNEAACVLVDNK
               || |. |  .|.. ||..|.| ..||.|.|  .|..   .|.|.||||...|.| .. ...||. ..
...............rglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlalde
subfamily_PPP1C_pd Subfamily PPP1C 505-785 5.8e-62 202.4 In-house 17-269 (282) alignment 
Range on Protein: 505-785
Range on HMM: 17-269/282.0
TICSQAVDIFANENRLLPVKSPCYVLGDLHGNFHDLICFekvlWRMGPILTPASFMFLGDYVDRGDFGFEVISYLFAQKLLMPSKFLLIRGNHEIRSVQE
.....| .|. ..  || .. |  ..||.||...||. .    . .. . . ....||||||||| .. |.|  |.| |.  |... |.|||||  |...
allkkareillsqpilleleaPvkivgdihGqyadllrl....fetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesasinr

SFTYKTECYHKFGESlgeeVWEATNTVFDAMPVAAVIDEKVFCVHGGIPHPSHgggYISAINDIPNHLPEPAEgsPLAWDIMWNDPirkeDEDNddslrt
 . .. || ....      .|.. . ||. .|.||..|||..|||||.    .    .. |..|   |  | .   |. |..| ||    |...      
iyGfydeckrrysik....lWktftdvfnclPlaalvdekilcvhGGlspelk...sleqirkiqrPlevpek..gllcdllWsdp....dkev......

elvgnEGFIDNDsRGTGHMFSSDALDSFLRRNNLSHVIRAHEVKETGFQLQQNGRLLTVFSSSHYCGSTNEAACVL-VDNKK
     .|. .|| ||  . |..|....||..|.|. ..|||.| | |... .. .|.||||...|||. ..|..|| ||...
.....lgwsend.rGvsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeel
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 491-785 4.2e-56 183.0 In-house 4-271 (287) alignment 
Range on Protein: 491-785
Range on HMM: 4-271/287.0
WGAIDMGSvARCFLTICSQAVDIFANENRLLPVKSPCYVLGDLHGNFHDLICFEKVLwrmGpILTPASFMFLGDYVDRGDFGFEVISYLFAQKLLMPSKF
.|..|  |  .  |..  .. .|.   . || |..|  ..||.||...||. . .     |   .   ..|||||||||   .||. .||. |...| | 
ygvldafs.dkdilevlekieeileplpalleveapitivGdihGqlddllrifnav...G.aapkvqylflGdyvdrGakslevslllfslkiaypkkv

LLIRGNHEIRSVQESFTYKTECYHKFGeslgEEVWEATNTVFDAMPVAAVIDEKVFCVHGGIPHPSHGGGYISAINdIPNHLPEPAEGspLAWDIMWNDP
 |.|||||.. . . . .| |  .|..    |....  | ||. .|. | ......|.|||| .  .    . |..  |..  .  ||  |  |..| ||
hllrGnhevkkinklyGfkeelkrkrq....erlykqfndvfselplcarvskrilcmhGGispklksldslkalk.kpttplacdeg..lqvdllwadp

IRKEDednddslrtelvgneGFIDNDSRGTGHMFSSDALDSFLRRNNLSHVIRAHEVKETGFQLQQNGRLLTVFSSSHYCGSTNEAACVLVDNKK
 .. .               .|  |  |.   .|    .|..|.. ... ..|||||.| |...  . ||.||||...|.|   . ..|.| .| 
ekdak...............tfelnkiraisvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvsks
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 504-785 4e-54 176.7 In-house 30-284 (298) alignment 
Range on Protein: 504-785
Range on HMM: 30-284/298.0
LTICSQAVDIFANENRLLPVKSPCYVLGDLHGNFHDLIC-FEKvlwrmGPILTPASFMFLGDYVDRGDFGFEVISYLFAQKLLMPSKFLLIRGNHEIRSV
 .....| .||.. . |. |..|  | ||.||.. ||.  |.|     .     | ..||||||||| . .|||  |.| |.  |..|.|.|||||. ..
eklielakkifkkqkslvevdapikvcGdihGqysdllrlfdk.....agfppdanylflGdyvdrGrqnlevivlllaykvkypnnffllrGnheceai

QESFTYKTECYHKFGESLgeeVWEATNTVFDAMPVAAVIDEKVFCVHGGIPHPSHgggYISAINDIPNHLPEPAEgsPLAWDIMWNDPIRKedednddsl
 . . .. || ... .     .... . ||.|.|..|.| ....|.|||. .  .    .. ....     .. |   || |..| || ..         
nrvyGfyeeckrrykslr...lyaefqdvfnalpltaliggrilcmhGGlskklk...sldqlrelkrpfdskee..slaidllwadpena.........

rtelvgNEGFIDNdSRGTGHMFSSDALDSFLRRNNLSHVIRAHEVKETGFQLQQNGRLLTVFSSSHYCGSTN-EAACVLVDNKK
       .|. .| ||| . .| .|..  .| . ..  |.||| |   |...  . .|.|.||. ||||. .  || . ||.| 
......vkgwaen.srGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdekl
subfamily_PPG1_pd Subfamily PPG1 505-785 6.9e-54 176.1 In-house 21-285 (300) alignment 
Range on Protein: 505-785
Range on HMM: 21-285/300.0
TICSQAVDIFANENRLLPVKSPCYVLGDLHGNFHDLICfekvLWRMGPILTPASFMFLGDYVDRGDFGFEVISYLFAQKLLMPSKFLLIRGNHEIRSVQE
 .. .  ... .|  .  ..||  |.||.||.|.|..     ....|  .  . ..||||||||| .  | || | . ||  ||.  |.||||| | . .
eltdklkellvkesnvieirspvtvvgdvhgqfydvle....ifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrqitq

SFTYKTECYHKFGESlgEEVWEATNTVFDAMPVAAVIDEKVFCVHGGIPHPSHGggyISAINDIPNHLPEPAEGSpLAwDIMWNDPirkeDEDNDDSLrt
.. . ||| .|.|      ||.    .|| . .||.|||...|||||.         |  |. .      | ||. || |..| ||    .|.|. .|  
vygfyteclrkyggn..srvwkylteifdylvlaaiideeiycvhgglspsvls...idqikvldrfrevpnega.la.dllwsdp....eennnptl..

ELVGNEG-FIDNDSRGTGHMFSSDALDSFLRRNNLSHVIRAHEVKETGFQLQQNGRLLTVFSSSHYCGSTNEAACVLVDNKK
.   .|| .. .  ||.|. .  |    ||| |.. ..||||..   |.|.  ...| ||.|.  ||    . | .|  ..|
dhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyek
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 504-788 8.3e-54 175.8 In-house 12-294 (302) alignment 
Range on Protein: 504-788
Range on HMM: 12-294/302.0
LTICSQAVDIFANENRLLPVKSPCYVLGDLHGNFHDLICF-------EKVLWRMGPILTPASFMFLGDYVDRGDFGFEVISYLFAQKLLMPSKFLLIRGN
|..... .. . .|. |  . .|  ..||.||.|.||.         |.   ..    .   |.|||||||||.   | |. .|| |.| |....|.|||
lllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillrgn

HEIRSVQESFTYKTECYHKFGESLGEEVWEATNTVFDAMPVAAVIDEKVFCVHGGIPHPSHGggyISAINDIPNHLPEPAEgSPLAWDIMWNDPIrkede
|| .... ..... |   ..|.. | |.||  | ||  ||.||.. ||..|||||| .  .    .  |..| . |.| .|  .|| |... ||.     
hetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispkles...ledikkikrplkevte.dslaqdllfadpl.....

DNDdSLrTELVGNEGFIDNDSRGTGHMFSSDALDSFLRRNNLSHVIRAHEVKETGFQLQQNGRLLTVFSSSHYCGST-NEAACVLVDN-KKIRT
| . .| .    .  .. |  ||  ..|   |.  . .| ||. ..||| .  .||..  . .|||.||.. |   . |. | . ||   |.  
dvq.ll.aavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsi
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 504-788 1.2e-53 175.3 In-house 13-295 (302) alignment 
Range on Protein: 504-788
Range on HMM: 13-295/302.0
LTICSQAVDIFANENRLLPVKSPCYVLGDLHGNFHDLICF-------EKVLWRMGPILTPASFMFLGDYVDRGDFGFEVISYLFAQKLLMPSKFLLIRGN
|..... .. . .|. |  . .|  ..||.||.|.||.         |.   ..    .   |.|||||||||.   | |. .|| |.| |....|.|||
lllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillrgn

HEIRSVQESFTYKTECYHKFGESLGEEVWEATNTVFDAMPVAAVIDEKVFCVHGGIPHPSHGggyISAINDIPNHLPEPAEgSPLAWDIMWNDPIrkede
|| .... ..... |   ..|.. | |.||  | ||  ||.||.. ||..|||||| .  .    .  |..| . |.| .|  .|| |... ||.     
hetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispkles...ledikkikrplkevte.dslaqdllfadpl.....

DNDdSLrTELVGNEGFIDNDSRGTGHMFSSDALDSFLRRNNLSHVIRAHEVKETGFQLQQNGRLLTVFSSSHYCGST-NEAACVLVDN-KKIRT
| . .| .    .  .. |  ||  ..|   |.  . .| ||. ..||| .  .||..  . .|||.||.. |   . |. | . ||   |.  
dvq.ll.aavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsi
subfamily_PPP4C_pd Subfamily PPP4C 505-783 7.9e-52 169.2 In-house 23-273 (288) alignment 
Range on Protein: 505-783
Range on HMM: 23-273/288.0
TICSQAVDIFANENRLLPVKSPCYVLGDLHGNFHDLicfeKVLWRMGPILTPASFMFLGDYVDRGDFGFEVISYLFAQKLLMPSKFLLIRGNHEIRSVQE
..|..| .|. .|. .  |.||  | ||.||.|.||    . |...|      ...||||.|||| .  | .  | | |.  | .  ||||||| |.. .
alcakareilveesnvqrvdspvtvcgdihgqfydl....lelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrqitq

SFTYKTECYHKFGESlgeEVWEATNTVFDAMPVAAVIDEKVFCVHGGIpHPSHggGYISAINDIPNHLPEPAEGSpLAwDIMWNDPirkedEDNDdSlrt
.. .  || .|.|..   .||.    ||| ...||.||.|.||||||.  ||     .  |  |  .   | ||. |. |..| ||     || . .   
vygfydeclrkygsa...nvwryctevfdylslaaiidgkifcvhggl.spsi..stldeirsidrkqevphegp.lc.dllwsdp.....edae.g...

elvgnegFiDNDSRGTGHMFSSDALDSFLRRNNLSHVIRAHEVKETGFQLQQNGRLLTVFSSSHYCGSTNEAACVL-VDN
       .     ||.|..| ||. ..| ..|... ..|||..   |..|. | ..|||.|.  ||    . | .| .|.
.......w.avsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaailelde
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 504-786 1.9e-51 168.2 In-house 14-274 (284) alignment 
Range on Protein: 504-786
Range on HMM: 14-274/284.0
LTICSQAVDIFANENRLLPVKSPCYVLGDLHGNFHDLIC-FEKVLWR-MGPILTPASFMFLGDYVDRGDFGFEVISYLFAQKLLMPSKFLLIRGNHEIRS
. .| .| ..| .|.  | ...|  . ||.||.| ||.  ..   |  .        ..||||||||| |  |||. ||| |||.| | .|.||||| | 
ielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrgnhesrp

VQESFTYKTECYHKFGESLgeevWEATNTVFDAMPVAAVIDEKVFCVHGGIPHPSHGGGYISAIndiPNHLPEPAEGspLAWDIMWNDPirkedednD-D
|.  . . .|| ... |.|    .|| .  | |||..||...|..|.||||..       . ..      .  |  |  .  |. | ||        . .
vnmqygfyleckkryseal....yeafqlafnamplcavvskkiicmhggisedlldlkqldkl...erpidipdig..viadltwadp........eae

slrteLVgneGFiDNDSRGTGHMFSSDALDSFLRRNNLSHVIRAHEVKETGFQLQQNGRLLTVFSSSHYCGSTNEAACVLV-DNKKI
     ..   |. ..  ||.|..| ..|.. ||.. .|  |.|||.|   |...  . .|.|.||.  ||| ....|.||  |.. .
.....ve...gy.kesprgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelv
PPP_4 528-748 8.8e-51 165.7 In-house 2-197 (197) alignment 
Range on Protein: 528-748
Range on HMM: 2-197/197.0
YVLGDLHGNFHDLICfeKVLWRMGPILTPASFMFLGDYVDRGDFGFEVISYLFAQKLLMPSKFLLIRGNHEIRSVQESFTYKTECYHKfgesLGEEVWEA
.| ||.|| ..||.   |.|   |   .  |..||||||||| ...||. .|.| || .|... |.||||| .|... .. |.|. .|     |.|....
tvvGDiHGqlddlll..kllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek....hgkeilkk

TNTVFDAMPVAAVIDEKVFCVHGGIPHPSHGggyISAINDIPNHLPEPAeGSPLAWDI-MWNDPIrkedednddslrtelVGNEGfIDNDSRGTGHMFSS
...||| .|.||.|||||..||||...  .    .. |..| .  . |   . .. |. .|.||                  .|| . |  || |..|..
lqdvfdllplaalidekvlvvhgglsdeles...ldkierierkiespl.eeekrkdlllwsdpr...............eaqeg.lansvrGagllFgp

DALDSFLRRNNLSHVIRAHEVK
|. ..||..|||. .||.||.|
dvtekfleknnlkliirshelk
subfamily_PPP2C_pd Subfamily PPP2C 505-785 1e-50 165.6 In-house 24-276 (290) alignment 
Range on Protein: 505-785
Range on HMM: 24-276/290.0
TICSQAVDIFANENRLLPVKSPCYVLGDLHGNFHDLICfekvLWRMGPILTPASFMFLGDYVDRGDFGFEVISYLFAQKLLMPSKFLLIRGNHEIRSVQE
..| .| .|...|. . .||.|  | ||.||.||||.     |...|     . ..||||||||| .  | ...| | |. ....  ..||||| | . .
elcekakeilskesnvqevkcpvtvcgdvhgqfhdlle....lfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhesrqitq

SFTYKTECYHKFGESlgeEVWEATNTVFDAMPVAAVIDEKVFCVHGGIPHPSHGggyISAINDIPNHLPEPAEGsPLAwDIMWNDPirkedednDDslRt
 . .  ||  |.|..   .||.    .|| .|..|..||..||.|||.    .    . .|...      | || ||. |..| ||        ||  | 
vygfydeclrkygna...nvwkyftdlfdylpltalvdeqifclhgglspsidt...ldkiraldrlqevpheg.plc.dllwsdp........dd..r.

elvgnEGFIdNDSRGTGHMFSSDALDSFLRRNNLSHVIRAHEVKETGFQLQQNGRLLTVFSSSHYCGS-TNEAACVLVDNKK
     .|.     ||.|. |  |  ..| ..|.|....|||..   |..   . .. |.||.  ||    |.|| . .|.| 
.....ggwg.isprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddkl
PPP_5_Dcr2 528-748 1.1e-50 165.4 In-house 2-199 (199) alignment 
Range on Protein: 528-748
Range on HMM: 2-199/199.0
YVLGDLHGNFHDLIC-FEKVLwrmGPILTPASFMFLGDYVDRGDFGFEVISYLFAQKLLMPSKFLLIRGNHEIRSVQESFTYKTECYHKFgesLGEEVWE
.|.||||| ..||.. ..|     |   .  ...||||||||| ...||. .|.| ||..|... |.||||| ....| .. ..|. .|.    |.....
tvcGDlHGqlddlllilfkeg...gdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlsky...hgkkiyk

ATNTVFDAMPVAAVIDEKVFCVHGGIPHPSHGGGYISAINDiPNHLPEpaEGSPLAWDIMWNDPIrkeD---EDnddslrtelvgnegfIDNDSRGTGHM
... ||| .|.||.|||||..||||...  .    . .|.. . ..||  |    |. ..|.||    |   ..                 |  || |..
ilsdvfdwlPlaalidekvlvvhgglspeiksiellekier.kieipe..ekgekadlllwsdpr...daqegc...............klnseRGagll

FSSDALDSFLRRNNLSHVIRAHEVK
|. |. . ||..|||. .||.||.|
fgpdvtekfleknnlkliirshelk
PPP_2 529-748 3.8e-50 163.3 In-house 3-198 (198) alignment 
Range on Protein: 529-748
Range on HMM: 3-198/198.0
VLGDLHGNFHDLICFEKVLwrmgPILTPASFMFLGDYVDRGDFGFEVISYLFAQKLLMPSKFLLIRGNHEIRSVQESFTYKTECYHKFGeslGEEVWEAT
|.|||||...||. . |.        .  ...|||||||||....||. .|.| || .|... |.||||| ..|.. ...|.|. .| |   |..|... 
vcGDlHGqldDLlilfkng....lpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkg...gkkvykkl

NTVFDAMPVAAVIDEKVFCVHGGIPHPSHgggYISAINDIPNHLPEPAEGSPLAWDimwN--DpirkedednddslRTELVGNEGFIDNDSRGTGHMFSS
. ||...|.||.|||||..||||. .  .    .. |. . ..   |.||. |      .  .              ..   .|... |..||.| .|..
qevfelLplaalidekvlvvHGGlseeik...lldqikkeerkiespeegklldll...eeek.............lsdpkekeellansarGagllfgp

DALDSFLRRNNLSHVIRAHEVK
|. ...|..|.|. .|||||||
dvteelleknklkliiRaHevk
subfamily_PPP6C_pd Subfamily PPP6C 505-785 7.9e-50 162.6 In-house 22-274 (290) alignment 
Range on Protein: 505-785
Range on HMM: 22-274/290.0
TICSQAVDIFANENRLLPVKSPCYVLGDLHGNFHDLicfeKVLWRMGPILTPASFMFLGDYVDRGDFGFEVISYLFAQKLLMPSKFLLIRGNHEIRSVQE
 .|.. .|.. .|  . ||.||  | ||.||.|.||    . |.| |  .  .|..||||.|||| . .| ...|.. |.  |..  |.||||| | . .
klcdlvldllleesnvqpvsspvtvcgdihgqfydl....eelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesrqitq

SFTYKTECYHKFGESlgeEVWEATNTVFDAMPVAAVIDEKVFCVHGGIPHPSHgggYISAINDIPNHLPEPAEGSplAWDIMWNDPirkedEDNDDslrt
 . .  || .|.|..   ..|     ||| ...||.|||.|.|||||.    .    .  |. |      | .|.    |..| ||     || ..    
vygfydeclnkygna...nawkyctkvfdlltiaaiideqvlcvhGglspdvk...tldqirvieraqeiphkga..fcdlvwsdp.....edvet....

elvgnegfIDNDSRGTGHMFSSDALDSFLRRNNLSHVIRAHEVKETGFQLQQNGRLLTVFSSSHYCGSTNEAACVLV-DNKK
            .||.|..| |   ..|.. |||. ..|||.. | |.. . . .| ||.|.  ||    . |..|  ....
........wavsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledae
subfamily_PPP5C_pd Subfamily PPP5C 507-783 2.1e-49 161.2 In-house 43-296 (322) alignment 
Range on Protein: 507-783
Range on HMM: 43-296/322.0
CSQAVDIFANENRLLPVKSP----CYVLGDLHGNFHDLICFEKVlwrMGPILTPASFMFLGDYVDRGDFGFEVISYLFAQKLLMPSKFLLIRGNHEIRSV
 ..| ... ..  |. .. .      | ||.||.|.||.   ..    |   .  ...| ||.|||| | .|||  |.. ||| | .| | |||||  ..
lleakellkklpslveitieetkkltvcGdihgqfydllnifel...nGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnm

QESFTYKTECYHKFGEslgeEVWEATNTVFDAMPVAAVIDEKVFCVHGGIPhpSHGGGYISAINDIPNHLPEPAEGSplAWDIMWNDPIRKEdednddsl
 . . .. |. .|. |    .| .  . ||. .|.| ||.|||. ||||..  |. |  .. .  |  .  .| ||     ...| || ...        
nklyGfegevkakyte....kvadlftevfnwlPlahvinekvlvvhGGlf..sedgvtlddlrkidrnaqppeegl..lvellwsdpqean........

rtelvGnegfIDNDSRGTGHMFSSDALDSFLRRNNLSHVIRAHEVKETGFQLQQNGRLLTVFSSSHYCGSTN-EAACVLVDN
     |    . . .||.|. |  |  . ||. |||...||.|||||.|......|.|.||||.  || ...  .| . . .
.....G....rspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrg
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 505-786 6.6e-49 159.8 In-house 10-264 (284) alignment 
Range on Protein: 505-786
Range on HMM: 10-264/284.0
TICSQAVDIFANENRLLPVKSPCYVLGDLHGNFHDLIcfeKvLWRMGPILTPASFMFLGDYVDRGDFGFEVISYLFAQKLLMPSKFLLIRGNHEIRSVQE
|.  .|..|| ..  |. |.||  . ||.||.| ||.   . |.    .   | ..|||||||||   .| |  ||| |...| .|...|||||   ...
tllfhafsifnkqpmlievnspinicgdihgqfsdll...r.lfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslink

SFTYKTECYHKFGESlgeEVWEATNTVFDAMPVAAVIDEKVFCVHGGIPHPSHGGGYISAINDiPNHLPEPAegsPLAWDIMWNDPIRKEdednddslrt
 . .  || ... .     |. . . ||  ||..|.. ....|.|||. .  .    . ||.  |   |||     || ||.| ||   .          
iygfyeecqrrynkp...svyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikr.pfdnpepn...tlaidilwsdptnfq..........

elvgnEGFiDNDSRGTGHMFSSDALDSFLRRNNLSHVIRAHEVKETGFQLQQNGRLLTVFSSSHYCGSTNEAACVLVDNKKI
     .|. . .|||  ..| ||||  .| | ..  |.|||.| . |...  | ||.|.||.  |||  ..||.|.  ||..
.....kgw.npnsrgvsyvfgsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknl
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 503-785 7.4e-49 159.5 In-house 13-266 (281) alignment 
Range on Protein: 503-785
Range on HMM: 13-266/281.0
FLTICSQAVDIFANENRLLPVKSPCYVLGDLHGNFHDLICFEKVLWRMgpilTPASFMFLGDYVDRGDFGFEVISYLFAQKLLMPSKFLLIRGNHEIRSV
. ..  ..  ||..|. |  ...|. |.||||..|.||.   ..| |.    .   ..|||||||||  ..||.  ||. |.  . . .|.|||||| ||
ienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrv....peevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasv

QESFTYKTECYHkfgeSLGEEVWEATNTVFDAMPVAAVIDEKVFCVHGGIpHPShgGGYISAINDIPNHLPEPAEGspLAWDIMWNDPIRKEDEdnddsl
.  . .  ||        |||.|   .. |. .|..| |...| |.|||.  |      .  . ..|. . ..  |  |  |..| ||  |  |      
nkiygfyvecvt....kyGeelwalfqrcfnrlpisaliakrvlcmhGGl.sPe..ltaldelrnrpkpirnldrG..lviDllwadpdnkvee......

rtelvgnegFiDNDSRGTGHMFSSDALDSFLRRNNLSHVIRAHEVKETGFQLQQNGRLLTVFSSSHYCGSTNEAACVLVDNKK
         .  . |||....|  . .|   .| ..  .|||| |   |... .  .|.||||   ||   ..||.||  ...
.........w.kassrGssftfGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdet
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 491-780 1.6e-47 154.9 In-house 10-273 (290) alignment 
Range on Protein: 491-780
Range on HMM: 10-273/290.0
WGAIDMGSvARCFLTICSQAVDIFANENRLLPVKSPCYVLGDLHGNFHDLICFEKVLWRMgPiltPASFMFLGDYVDRGDFGFEVISYLFAQKLLMPSKF
.|..|  |  .  |.|  .. .|.     || |..|  ..||.||.. .|. . . . .  |      |.|||||||||   .||  .||  |.... | 
ygvldafs.dkdileilekieeileplpalleveapivivgdihgqldallryfdavgyp.p...kvkflflgdyvdrgakslevslllfcykiryskkv

LLIRGNHEIRSVQESFTYKTECYHKFGeslgEEVWEATNTVFDAMPVAAVIDEKVFCVHGGIPHPSHGGGYISAINDiPNHLPEPAEGspLAWDIMWNDP
 |.|||||.| |.  . .| |   | |     ..|   . ||. ... | ...|..|.|||| .  .    . |..  |.   .  ||  |  |..| ||
hllrgnhevrkvnrlygfkeelarkrg....srlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkk.prvpltcdeg..lqvdllwadp

IRkedeDNDDSlrtelvgnegFIDNDSRGTGHMFSSDALDSFLRRNNLSHVIRAHEVKETGFQLQQNGRLLTVFSSSHYCGSTNEAACVL
 |    | ||.          .  |  |.   .|  ..||..|..  || ..||||||| ||... . .|.||||. .|.|   .  ...
tr....dkddt..........ialnkqraisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaia
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 558-786 2e-46 151.6 In-house 102-305 (317) alignment 
Range on Protein: 558-786
Range on HMM: 102-305/317.0
SFMFLGDYVDRGDFGFEVISYLFAQKLLMPSKFLLIRGNHEIRSVQESFTYKTECYHKFGESLgeevWEATNTVFDAMPVAAVIDEKVFCVHGGIPHPSH
 ..||||||||| | .||.. ||| |||.| |  |.||||| |.|  .. . .|. ... ..|    .|| ...| ..|..||...|..|.||||..   
kylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaal....yeafqlafnvlplcavvnkkilcmhGGiseell

GGGYISAINdIPNHLPEpaEGspLAWDIMWNDPIRKEDednddslrtelvgneGFiDNDSRGTGHMFSSDALDSFLRRNNLSHVIRAHEVKETGFQLQQN
    .....  | ..|.   |  .  |. | ||  ...               |.  . .||.|..| ..|.. ||.. .|  |.|||.| | |... ..
dlkqldklk.rpldipd..vG..vladltwadpdaevk...............gy.kesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffad

GRLLTVFSSSHYCGSTNEAACVLVDNKKI
 .|.|.||.  ||| ....|.||  .||.
rklvtifsapsycGqldniaavlsvdkkl
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 506-785 6e-46 149.8 In-house 14-265 (280) alignment 
Range on Protein: 506-785
Range on HMM: 14-265/280.0
ICSQAVDIFANENRLLPVKSPCYVLGDLHGNFHDLIC-FEKVlwrmgPILTPASFMFLGDYVDRGDFGFEVISYLFAQKLLMPSKFLLIRGNHEIRSVQE
.  .  .|.. .. .. |..|  | |||||.. ||.  |..|      .     ..||||||||| . .|||  |.| |.  | .||..|||||. |...
viekckkiltaqatmvevdapvavcgdlhgqytdllrlfarv.....sfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisinr

SFTYKTECYHKFGEslgeEVWEATNTVFDAMPVAAVIDEKVFCVHGGIPHPSHGggyISAINDIpnHLPEPAEGSPLAWDIMWNDPirkedeDNDDSlrt
 . .| |..... .    ....  . ..| .|..|..  ...|.|||. .       .. ....  . |  .| . || |..| ||      .|. .   
kygfkdevkrrysl....alynefqelldslplvalvsgrilcmhgglsqklvs...lddlael..rrpfdsedeclamdllwadp......enkvt...

elvgneGFIdNDSRGTGHMFSSDALDSFLRRNNLSHVIRAHEVKETGFQLQQNGRLLTVFSSSHYCGS-TNEAACVLVDNKK
      |.  ..|||. ..| .. .  . .. ..  ..| |.| . |...  . .|.||||. .|.|. .|.|| . ||.. 
......gwa.ensrgvsvifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderl
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 520-786 3.6e-43 141.1 In-house 2-246 (263) alignment 
Range on Protein: 520-786
Range on HMM: 2-246/263.0
LLPVKSPCYVLGDLHGNFHDLIcfeKVLWRMGpILTPASFMFLGDYVDRGDFGFEVISYLFAQKLLMPSKFLLIRGNHEIRSVQESFTYKTECYHKFG-E
|| ...|  . || ||.. ||.   ...   |   | . ..||||||||| . .|||  ||. || || |. |.|||||...... . ...|  ..|  |
llelqapinicgdthgqyndll...rifnacg.aatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqre

SLGEEVWEATNTVFDAMPVAAVIDEKVFCVHGGIPHPSHgggYISAINDIPNHLpEPAEGSPLAWDIMWNDPirkedE-DnddslrtelvgNEGFIDNDS
 . | |..  | ||  ||..|.. ....|.||||    .    .  |  ||  | | |.  ||| |..| ||     | |            .||  |  
evyesvynhfnqvfsymplcaivskrilcmhggisphlk...slddiraiplpl.etakthplacdllwadp.....ekd...........akgfepnki

RGTGHMFSSDALDSFLRRNNLSHVIRAHEVKETGFQLQQNGRLLTVFSSSHYCGSTNEAACVLVDNKKI
|    .|    .| . .| ..  ..|||.| | |. .  . ||.||||.|.|     . |.|.| || .
raisnvfgkkevddlckrldidlivrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkml
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 502-789 3.9e-42 137.5 In-house 28-288 (299) alignment 
Range on Protein: 502-789
Range on HMM: 28-288/299.0
CFLTICSQAVDIFANENRLLPVKSPCYVLGDLHGNFHDLICF-EKVlwRMGPiltPASFMFLGDYVDRGDFGFEVISYLFAQKLLMPSKFLLIRGNHEIR
 . |.|. | ..||... || |..|  | ||.||.. ||. . .|   .. |    . |.|||||||||   .|.|. |.. |. .| .| ..|||||  
elqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdka..gfpp...dvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecp

SVQESFTYKTECYHKFGESlgeEVWEATNTVFDAMPVAAVIDEKVFCVHGGIPhPShgGGYISAINDIPNHLPEPAegSPLAWDIMWNDPirkedednDD
...  . .  || ...  .    .| . .  |.|||.. .|  ...|.|||.  |      .  . |..     |.    |  |..| ||        |.
ainrvygfyeecnkrykst...rlwsifqdafaampltgligsrilcmhggls.pk..lqtldqlrdltrpqdppn..pslgidllwadp........dq

SLRtelvgneGFIdNDSRGTGHMFSSDALDSFLRRNNLSHVIRAHEVKETGFQLQQNGRLLTVFSSSHYCGST-NEAACVLVDNKKIRTI
|..       ..  .. ||  ..|  | .   . | ..  | |||.| . |...  . .|.|.||. ||||   | || . ||.. . |.
svk.......dwl.anvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctf
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 504-786 8.5e-42 136.4 In-house 29-285 (297) alignment 
Range on Protein: 504-786
Range on HMM: 29-285/297.0
LTICSQAVDIFANENRLLPVKSPCYVLGDLHGNFHDLIcfeKVLWRmGPILTPASFMFLGDYVDRGDFGFEVISYLFAQKLLMPSKFLLIRGNHEIRSVQ
| .   |.|.| ... .. |..|  | ||.||.| ||.   ... | |     | ..||||||||| |  | |  |.| |. .|....|.|||||   |.
lklldlaldvfkaqksmvevnapikvcgdihgqfpdll...rlfhr.ggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecefvn

ESFTYKTECYHKFGeSLgeEVWEATNTVFDAMPVAAVIDEKVFCVHGGIPHPSHGGGYISAIndipNHLPEPAEGS-PLAWDIMWNDPIrkedednddSl
. . .  || ...  |.   .. | . ||. .|.. .| .|..|.|||.         . ..    ...  . ||   |  |..| |||         | 
kvygfyeecqkryq.sv..rmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtl....rkierstegkerlvadllwadpi.........s.

rtelvGNEGFIDNDsRGTGHMFSSDALDSFLRRNNLSHVIRAHEVKETGFQLQQNGRLLTVFSSSHYCGSTNEAACVLVDNKKI
     |  ||..|. ||.|  |  ||.       .|  | |||.| . |...    .|.|.||. ||||  ...|...  ..|.
.....glsgfmenq.rgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdekl
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 503-782 2e-40 131.9 In-house 25-278 (307) alignment 
Range on Protein: 503-782
Range on HMM: 25-278/307.0
FLTICSQAVDIFANENRLLPVKSPCYVLGDLHGNFHDLICFEKVLWRMgPiltPASFMFLGDYVDRGDFGFEVISYLFAQKLLMPSKFLLIRGNHEIRSV
|  .  .|  ||. |. |. .  || |.|||||.| ||| .  .| |  |    . ..| ||||||| . .|.|  ||. |. .| . .|.||||||  |
fenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrp.p...etvyvftgdyvdrgllslecilllftykicypenivllrgnheiarv

QESFTYKTECYHKFGEsLGEEVWEATNTVFDAMPVAAVIDEKVFCVHGGIphpSHGGGYISAINDIPNHLPEPAEGspLAWDIMWNDPirkedednDDSL
.. ...  ||        |||.|   . .|. .|..|.|  |..|.|||.   |     .  . . |. . .|  |  .  |..| ||        | |.
nkkygfyeecvtsipk.cgeeiwalfqrcfnnlpisaliatkilcmhggl...spaltcldelrnhpkpirnpfrg..ivndmlwadp........dpsv

rTElvgnegfIDNDSRGTGHMFSSDALDSFLRRNNLSHVIRAHEVKETGFQLQQNGRLLTVFSSSHYCGSTNEAACVLVD
  |           |||.|  | .. .|   .|  .  .||||..   |. .    .|.|.||.  ||   ..| |||  
.fe.......wkassrgsgftfgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkv
subfamily_PPZ_pd Subfamily PPZ 503-780 2.9e-38 125.1 In-house 30-278 (300) alignment 
Range on Protein: 503-780
Range on HMM: 30-278/300.0
FLTICSQAVDIFANENRLLPVKSPCYVLGDLHGNFHDLIcfeKVLWRMGpILTPASFMFLGDYVDRGDFGFEVISYLFAQKLLMPSKFLLIRGNHEIRSV
 | || .| ..| ..  || .  .  ..||.||.. ||.   ... . | .   | ..|||||||||   .| |  |.. |.  | .|.|.|||||   |
ilqicikarelflaqpallelspsvkivgdvhgqyadll...rlftkcg.fppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecanv

QESFTYKTECYHKFgeslGEEVWEATNTVFDAMPVAAVIDEKVFCVHGGIPHpshgggYISAINDIpNHLPEPAE--GSPLAWDIMWNDPIRKEDEdndd
   . .  || ..       ..|..    |...|.||..  |.||||||.         . ....|  |.  |..     |  |..|.||    .|    
trvygfydeckrrc....nikiwktfvdtfntlplaaivagkifcvhgglsp......vlnsmdei.rhvvrptdvpdfglindllwsdptdssne....

slrtelvgnegFIDNdSRGTGHMFSSDALDSFLRRNNLSHVIRAHEVKETGFQLQQNGRLLTVFSSSHYCGSTNEAACVL
           . ||  ||  . .   |.. || .  .  | ||| | | |... ..  |.||||.  |||  ..  .|.
...........wedn.ergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavm
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 506-785 4.4e-38 124.3 In-house 14-264 (280) alignment 
Range on Protein: 506-785
Range on HMM: 14-264/280.0
ICSQAVDIFANENRLLPVKSPCYVLGDLHGNFHDLICFEKVLWRMgpilTPASFMFLGDYVDRGDFGFEVISYLFAQKLLMPSKFLLIRGNHEIRSVQES
|      || .|. |   ..|  |.||.| ...|.  .  .. |.        .||||||||||  | ||.  ||. |.    .  |.|||||  ||.. 
iirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrv....peeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnki

FTYKTECYHKFGESLgeevWEATNTVFDAMPVAAVIDEKVFCVHGGIphpSHGGGYISAINDIPNHLpEPAEGSpLAWDIMWNDPIRKedednddslrte
. .  || .|.|  |    |   ...|. ||....| ..|.|.|||.   |     . .| .||    || .   |  |..|.||  |            
ygfyvecqykygvgl....wwdfqscfnrmpmsgliskrvlcmhggl...spelinldtirniprpc.epldrg.llidllwsdptnk............

lvgNEGFIDnDSRGTGHMFSSDALDSFLRRNNLSHVIRAHEVKETGFQLQQNGRLLTVFSSSHYCGSTNEAACVLVDNKK
    ||..    ||  .||    ..   .  ..  .||||.| . |...    ||.||||   ||    .||.|.. | .
...gegwfh.sirgisymfgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnan
subfamily_PPP7C_pd Subfamily PPP7C 529-779 5e-38 123.8 In-house 68-319 (383) alignment 
Range on Protein: 529-779
Range on HMM: 68-319/383.0
VLGDLHGNFHDLICfekVLWRMGPILTPASFMFLGDYVDRGDFGFEVISYLFAQKLLMPSKFLLIRGNHEIRSVQESFTYKTECYHKFGEsLGEEVWEAT
| |||||.. ||.    .|.. |   .  ...| ||.||||  . |..  |.|  |..| .. | |||||   .   . .  |  .|. .  |... .  
vcGdlhGklddlll...ilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykv.hgkkilrll

NTVFDAMPVAAVIDEKVFCVHGGIPHPSHgggyISAINDIPNHLPEPAEGSPLAWDI-----MWNDPI---RKEDEDNDDSLRTELVGNEGFIDNDSRGT
. ||  .|.|..||||.. ||||| . ..    .. .. |  .       .||  .        .  .   ..| .   | | ..   .||   |  ||.
edvfawlplatlidekilivhGGisdktd....lelldkiersklvsvlrpplkegeeaekekeessvkvdkeewrqvldilwsdpkakeGckpntlrGg

GHMFSSDALDSFLRRNNLSHVIRAHEVKETGFQLQQNGRLLTVFSSSHYCG-STNEAACV
|  | .|  ...|.. ||. .||.|| |  |...  . ..||.||.| |    .|  | |
GsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayv
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 559-787 2.8e-35 115.0 In-house 122-325 (339) alignment 
Range on Protein: 559-787
Range on HMM: 122-325/339.0
FMFLGDYVDRGDFGFEVISYLFAQKLLMPSKFLLIRGNHEIRSVQESFTYKTECYHKFGESLgeevWEATNTVFDAMPVAAVIDEKVFCVHGGIPHPSHG
..||||||||| | .||.  | | ||  | .  |.||||| |||. |. .  |  ...   |    .|. . .|. .|..|||.. ..|.||||      
ylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaql....yecfqnmfnvfpfcavinntimcmhggisehlts

GGYISAInDIPNHLPEpaEGspLAWDIMWNDPirkedednDDslrTElvgnEGFiDNDSRGTGHMFSSDALDSFLRRNNLSHVIRAHEVKETGFQLQQNG
   .| .   |  .|.   |  .  |. | ||        |    ||    .|.    .||.  .|   || .||.. .|  ||| |.| | |... .  
fnqfsvf.krpleipd..vg..vltdltwadp........dp...te....kgy.kpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgr

RLLTVFSSSHYCGSTNEAACVLVDNKKIR
||.|.||.  |||  ...|.|.  .||..
rlvtifsapnycgqndntaavfsidkklk
Metallophos Calcineurin-like phosphoesterase 528-748 4.8e-29 95.0 Pfam-A 4-199 (200) alignment 
Range on Protein: 528-748
Range on HMM: 4-199/200.0
YVLGDLHGNFHDL-IcFEKVLWRMGPILTPASFMFLGDYVDRGDFGFEVISYL--FAQKLLMPSKFLLIRGNHEIRSVQESFTYKTECYHK---------
 |.|||||...|| . ..  | ...    |  . ||||.||||| . |.. .|  ...|||.| .. |.||||| ... . .  . |...          
lvigDlHgglddled.lllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglangee

---------------------FGESLGEEVWEATNTVFDAMPVAAVIDEKVFCVHGGIPHPSHGGGYIsaindipnhlpepaegsplawdimwndpirke
                     ..  || ...|... .|.|.| .| .| |....||.. ..   |  |                                
eyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi................................

dednddslrtelvgnegfidndsrgTGHMFSSDALDSFLRRNNLSHVIRAHEVK
                          .  |..|||. .|..... .|.|.|. |
.........................gselfgpdalekllekygvdlvlrGHtHk
EF-hand_1 EF hand 244-270 2.4e-06 16.5 Pfam-A 2-28 (29) alignment 
Range on Protein: 244-270
Range on HMM: 2-28/29.0
CQFIFRFYNVSGKGFMSFQEFREMVRD
.. .|. . . | |..||.||.|....
lkeaFkefDkDgdGkIsfeEfkealkk