Gene PFKFB in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily PFKFB
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP189_AA protein Get Run
AqueP189_AA_235-447 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PFKFB_pd Subfamily PFKFB 237-432 2.3e-99 322.7 In-house 1-197 (198) alignment 
Range on Protein: 237-432
Range on HMM: 1-197/198.0
NIHIRPRSIYLCRHGESICNMYGRIGGDSELSERGFEFARKLSEYISTQDLPGLKIWTSQLKRTKQTAELLDGPKEQWRALNELDVGDCEALSYEQIQEK
|||..||.|||.||||| .|..|||||||||.||| |.|.||...|....|  |..|||.|||| ||||||. |||||.||.||| |.|. |.||.|.||
nihlkpreiylvRhGeseknkkgriggdseLterGveyakklakfikeenlkelrvwtselkrtiqTaellglpkeqwkaLdeldaGkcdgltyeeikek

FPREFALRDQDKYRYRYPRGESYEDLVHRLEPVIMELER-QDNVLVICHQAVSRCILAYFLDKSNEELPYIRVPLHSIIKLTPVAYGCKVESHKIDV
||.||. |..|||||||||||||||||.||||||.|||| |.|||.|.|||| |..|||.|||| |||||..||||..|||||||||||||..|.||
fpeefkerkkdkyryryprgEsyedlvqRlepvileLereqenvliiaHqavlrvllaylldksaeelpylkvplhtvikltpvaYgckvellkldv
6PF2K 6-phosphofructo-2-kinase 27-242 1.6e-92 298.9 Pfam-A 7-223 (223) alignment 
Range on Protein: 27-242
Range on HMM: 7-223/223.0
PPVSNAKICIALVGLPARGKTYIARKLARYLNWIGVNTKVFNVGEYRRNAVGAEKTFEFFHPDNKEATEARRKCAIAALQDVQKFLE-EGGDAAVFDATN
.  .| |..| ||||||||||||..|| |||.|.||.|||||||.|||.|| |.. .|||.|||.||...|.|.| |||.|. |.|. |.|. |.|||||
knlknsklvivlvGLpargKtyiskkltrylkwlgvrtkvFnvgkyrreavkalsdaeffrpdneealklreklalaalkdllkylneeegqvaifDAtN

STKERRQLIIDHCQPHSIKVFFIESICDDPELVDENIKAVKLSSPDYSDRATDEAIEDFKKRIEVYKLAYCSLDKDEDKELSWVKIFNVKQRYEANQIEG
.|.|||.||.. .. ...||.|.||.|.|.|...|||| |||||||| |. |.|||.||.||.|.|. .| .||..||.|||..|...|.... .|...|
ttrerRklilefveennlkvlflesvcsdeeiikeNikevklsspDYkdketeeaikdflkRlenyekqyeplddeedeelsyIkvidvgkslvvnnvqg

HLQARLVYYLMNIHIRP
.||.| ||||.|||  |
ylqsrivyyllNihlkp
0039931 Phosphoglycerate mutase-like 245-447 4.2e-58 188.5 In-house 2-204 (219) alignment 
Range on Protein: 245-447
Range on HMM: 2-204/219.0
IYLCRHGESICNMYGRIGGDSELSERGFEFARKLSEYISTQDLPGLKIWTSQLKRTKQTAELLDGPKEQWRALNELDVGDCEALSYEQIQEKFPREFALR
.||.||||.  |  ||. |||.|.||| | ||.| |... ..||   ...| |.|. ||||... | |.. .|.|.| ||.| |..|.|.||.| |.|..
lyLvRHGetewnvegrlqgdspLterGreqaralgerlkdlglpfdavysSpllRaiqTaeiiglpveidprLrEidfgdlegltleeiaekypeelaaw

DQDKYRYRYPRGESYEDLVHRLEPVIMELERQDNVLVICHQAVSRCILAYFLDKSNEELPYIRVPLHSIIKLTPVAYGCKVESHKIDVPCVDTYRGKPEN
 .|.|.||.|.|||..|.|.|..|...||....||||..|..| |..|||.|. | ||......| .|...|.. ..|...... .  .  |..| .. .
lrdpydyrppggEsladvvaRvlpaleellagenvlvVsHggvirallayllglsleeilrlnlpngsvtvlelddggwvlvllnltshlddllrllllt

LEL
|||
lel
0035570 Phosphoglycerate mutase-like 245-431 1.9e-57 186.4 In-house 2-188 (219) alignment 
Range on Protein: 245-431
Range on HMM: 2-188/219.0
IYLCRHGESICNMYGRIGGDSELSERGFEFARKLSEYISTQDLPGLKIWTSQLKRTKQTAELLDGPKEQWRALNELDVGDCEALSYEQIQEKFPREFALR
.||.||||. .|  ||. ||..|.||| | ||.| |... ...|  ....| |.|. ||||... | |.. .|.|.| ||.| |....|.||.| |.|..
lyLvRHGetewnlegrlqgdvpLterGreqaralgealadlgipfdavysSpllRaiqTaeiiglpveidprLrEidfgdlegltldeiaekypeelaaw

DQDKYRYRYPRGESYEDLVHRLEPVIMELERQDNVLVICHQAVSRCILAYFLDKSNEELPYIRVPLHSIIKLTPVAYGCKVESHKID
 .|.|.||.|.|||..|.|.|..|...|||...||||..|..| |..|||.|. . ||......| .|...|.. ..|.|.. . ..
lrdpydyrppggEsladvvaRvlpaleeledgenvlvVsHggvirallayllglpleeilrlnlpngsvtvleldggggkwvlvlln
0053607 Phosphoglycerate mutase-like 242-426 1.7e-52 169.9 In-house 1-185 (191) alignment 
Range on Protein: 242-426
Range on HMM: 1-185/191.0
PRSIYLCRHGESICNMYGRIGGDSELSERGFEFARKLSEYISTQDLPGLKIWTSQLKRTKQTAELLDGPKEQWRALNELDVGDCEALSYEQIQEKFPREF
.. .||.||||.  |  ||. ||..|.|.| | ||.| |..  ..|.  ....| |.|. ||||... | |.. .|.|.| ||.| |..|...||.| |.
mtrlyLvRHGetewnaegrlqgdvpLtelGreqaralaellaelglkfdavysSpllRarqTaeiiglpvevdprlrEidfgdwegltleelaekypeel

ALRDQDKYRYRYPRGESYEDLVHRLEPVIMELERQDNVLVICHQAVSRCILAYFLDKSNEELPYIRVPLHSIIKLTPVAYGCKVE
|.. .|.. ||.|.|||..|...|..|...|| ...||||..|..| |..|||.|. . |||.....| .|...|..  .|....
aawlrdpldyrppggEsladvaaRvlpaleellaggnvlvVaHggvirallayllglpleellrlnlpngsvtvlelddggwvlv
0036777 Phosphoglycerate mutase-like 243-422 3.2e-50 163.3 In-house 3-221 (247) alignment 
Range on Protein: 243-422
Range on HMM: 3-221/247.0
RSIYLCRHGESICNMYGRIGG--DSELSERGFEFARKLSEYISTQDLPGLKIWTSQLKRTKQTAELL----D---GPKEQWRALNELDVGDCEALSYEQI
. .||.||||. .|  ||. |  |..|.|.| | |..| |......||  ....| |.|. ||||..    .    | ... .|.|.| |..| |....|
krlyLvRHGetewnaegrfqgwlDvpLtelGreqakalgellkelglpfdavysSpllRAiqTaeiilealglsllpvvvdprLrErdyGalegltkaei

QEKFPREFALRDQDKYRYRY-------------------------PRGESYEDLVHRLEPVIMELERQ-----DNVLVICHQAVSRCILAYFLDKSNEEL
.||.| |.... .|.| ||.                         | |||..|.|.|..|...|| ..     .||||..|..| |..|||.|. | |..
aekypeelvawwrdpydyrppllelllelllldllryallpldllpggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsledi

PYIRVPLHSIIKLTPVAYG
.....| .||..|.  ..|
lrlnlpngsitvleldddg
0037864 Phosphoglycerate mutase-like 236-427 3.9e-50 162.4 In-house 1-206 (211) alignment 
Range on Protein: 236-427
Range on HMM: 1-206/211.0
MNIHIRPRSIYLCRHGESICNMYGRIGG--DSELSERGFEFARKLSEYISTQDLPGLKIWTSQLKRTKQTAELL----D---GPKEQWRALNELDVGDCE
|....... .||.||||. .|  ||. |  |..|.|.| | ||.| |..  ..||   ...| |.|. ||||..    .    | |.. .|.|.| |..|
MslnllmtrlyLvRHGetewnaegrlqgwldvpLtelGreqaralgealadlglpfdavysSpllRaiqTaeiilealglpllpvevdprlrErdfgale

ALSYEQIQEKFPREFALRDQDKYRYRYPRGESYEDLVHRLEPVIMELERQ-----DNVLVICHQAVSRCILAYFLDKSNEELPYIRVPLHSIIKLTPVAY
 |..|.|.||.| |.. . .|.| .|.| |||..|.|.|..|...|| ..     .||||..|..| |..|||.|. | |||.....| .|...|.   .
gltleeiaekypeelvawlrdpydfrppggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsleellrlnlpngsvtvlelddg

GCKVES
|....|
gwvlvs
0049178 Phosphoglycerate mutase-like 243-427 3.2e-49 160.0 In-house 4-225 (243) alignment 
Range on Protein: 243-427
Range on HMM: 4-225/243.0
RSIYLCRHGESICNMYGRIGG--DSELSERGFEFARKLSEYISTQDLPGLKIWTSQLKRTKQTAELL----D---GPKEQWRALNELDVGDCEALSYEQI
. .||.||||.  | .||. |  ||.|.|.| | ||.| |......|.   ...| |||..||||..    .    | ... .|.|.| |..| |....|
trlyLvRHGetewnaegrlqgwtDspLtelGreqAralgellaelglkfdavysSplkRaiqTaeiilealglpllpvvvdprLrErdfGalegltkaei

QEKFPREFALRDQDKYRYRY-----------------------PRGESYEDLVHRLEPVIMELERQ-----DNVLVICHQAVSRCILAYFLDKSNEELPY
..|.| |.... .|.| .|.                       | |||..|.. |..|...|| ..     ..|||..|..| |..||..|. . |||..
aakypeelvawwrdpydarppalllldlllplldrlladldllpggEsladvaaRvlpaleellaellhdgktvlvVaHggvirallalllglpleellr

IRVPLHSIIKLTPVAYGCKVES
...| .|...|.   .|....|
lnlpngsvtvlelddggwvlvs
0043909 Phosphoglycerate mutase-like 242-423 3.3e-49 159.9 In-house 2-226 (249) alignment 
Range on Protein: 242-423
Range on HMM: 2-226/249.0
PRSIYLCRHGESICNMYGRIGG--DSELSERGFEFARKLSEYISTQDLPGLKIWTSQLKRTKQTAELL----D---GPKEQWRALNELDVGDCEALSYEQ
.. .||.||||.  | .||. |  ||.|.|.| | ||.| |.......|  ....| |||..||||..    .    | |.. .|.|.| |..| |....
mkrlyLvRHGetewnaegrfqgwlDspLtelGreqaralgealkelgipfdavysSplkRAiqTaeiileelgldklpvevdprLrErdfGalegltkae

IQEKFPREFALRDQ-----------------------------DKYRYRYPRGESYEDLVHRLEPVIMELERQ-----DNVLVICHQAVSRCILAYFLDK
| ||.| |.... .                             |.. .|.|.|||..|.|.|..|...|| ..     .|||...|..| |..|||.|. 
iaekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppggEsladvvaRvlpaleellarllkdggnvliVaHggvlrallayllgl

SNEELPYIRVPLHSIIKLTPVAYGC
| |.......| .||..|.. ..|.
sledilrlnlpngsitvlelddggk
0036887 Phosphoglycerate mutase-like 243-426 3.3e-48 156.2 In-house 2-193 (202) alignment 
Range on Protein: 243-426
Range on HMM: 2-193/202.0
RSIYLCRHGESICNMYGRIGG--DSELSERGFEFARKLSEYIStqDLPGLKIWTSQLKRTKQTAELL----DGPKEQWRALNELDVGDCEALSYEQIQEK
. .||.||||. .|  ||. |  |..|.|.| | ||.| |...  .||   ...| |.|. ||||..    . | ... .|.|.| |..| |..|.|.||
trlyLvRHGetewnvegrlqgdldvpLtelGreqaralgerla..glpfdavysSpllRaiqTaeiiaealglpvivdprlrEidfgalegltleeiaek

FPREFALRDQDKYRYRYPRGESYEDLVHRLEPVIMELERQ---DNVLVICHQAVSRCILAYFLDKSNEELPYIR-VPLHSIIKLTPVAYGCKVE
.| |.| . .|.| .|.|.|||..|.|.|......|| ..   .||||..|..| |..|||.|. | |.|...| .| .|...|.  ..|....
ypeelaawlrdpydfrppggEsladvvaRvlaaleellarldggnvlvVsHggvlrallayllglsledllrlrklpngsvtvlelddggwvlv
0051064 Phosphoglycerate mutase-like 242-425 6.6e-48 156.0 In-house 3-225 (241) alignment 
Range on Protein: 242-425
Range on HMM: 3-225/241.0
PRSIYLCRHGESICNMYGRIGG--DSELSERGFEFARKLSEYISTQDLPGLKIWTSQLKRTKQTAE----LLD---GPKEQWRALNELDVGDCEALSYEQ
.. .||.|||||  |  ||. |  |..|.|.| | ||.| |... ....  ....| |.|. ||||     |.    | ... .|.|.| |..| |..|.
mkrlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerladlgikfdavysSpllRaiqTaeiiaealglpllpvvvdprlrEidfgalegltlee

IQEKFPREFALRDQDKYRYRY-------------------------PRGESYEDLVHRLEPVIMELERQ-----DNVLVICHQAVSRCILAYFLDKSNEE
|.|||| |......|.. .|.                         |.|||..|...|..|.. || ..     .||||..|..| |..|||.|. . ||
iaekfpeelvawlrdpldvrppllelldlllllldlryagllddllpggEsladvaaRvlpaleellarllldgknvlvVsHggvirallayllglplee

LPYIRVPLHSIIKLTPVAYGCKV
|.....| .|...|.  ..|..|
llrlnlpngsvtvleldddgkrv
0048955 Phosphoglycerate mutase-like 245-421 5.7e-47 152.9 In-house 3-218 (240) alignment 
Range on Protein: 245-421
Range on HMM: 3-218/240.0
IYLCRHGESICNMYGRIGG--DSELSERGFEFARKLSEYISTQDLPGLKIWTSQLKRTKQTAE----LLD---GPKEQWRALNELDVGDCEALSYEQIQE
.||.|||||  |  ||. |  |..|.|.| | ||.| |... ....  ....| |.|. ||||     |.    | ... .|.|.| |..| |....|.|
lyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerLadlgikfdlvysSpllRaiqTaeiiaealglpllpvvvdprlrErdfgalegltldeiae

KFPREFALRDQDKYRYRY-------------------------PRGESYEDLVHRLEPVIMELE-----RQDNVLVICHQAVSRCILAYFLDKSNEELPY
||| |..|. .|.. .|.                         |.|||..|.. |..... ||      ...||||..|..| |..|||.|. . ||...
kfpeelvlwlrdpldvrppllelldellllldlryalldedllpggEsladvaaRvlaaleellaralkpgknvlvVsHggvirallayllglpleeilr

IRVPLHSIIKLTPVAY
...| .|...|.   .
lnipngsvtvlelddg
0050036 Phosphoglycerate mutase-like 245-416 9.5e-42 134.4 In-house 3-165 (171) alignment 
Range on Protein: 245-416
Range on HMM: 3-165/171.0
IYLCRHGESICNMYGRIGG--DSELSERGFEFARKLSEYIstqdlPGLKIWTSQLKRTKQTAELLDGPKEQWRALNELDVGDCEALSYEQIQEKFPRefa
.||.||||.. |..||. |  |..|.|.| . ||.| |..     |   ...| |.|. |||||.  | ... .|.|.| |..| |....|..|.|    
lyLvRHGetewnlegrfqgwtdvpLtelgraqaralgell.....pfdavysSpllRArqTaelillpvivdprLrErdfGawegltldeiaakype...

lRDQDKYRYRYPRGESYEDLVHRLEPVIMELErqDNVLVICHQAVSRCILAYFLDKSNEELPYIRVPLHSIIKL
 ...|......| |||..|...|. |.. ||   .||||..|..| |..||..|. | ||......| .|.. |
.wlldlldlappggEsladvlaRvlpaleell..gnvlvvaHggvirallalllglsleeilrlelpngsvlvl
His_Phos_1 Histidine phosphatase superfamily (branch 1) 245-390 4.9e-36 117.0 Pfam-A 2-157 (158) alignment 
Range on Protein: 245-390
Range on HMM: 2-157/158.0
IYLCRHGESICNMYGRIGGDSE--LSERGFEFARKLSEYISTQDLPGLKIWTSQLKRTKQTAELLDGPK----EQWRALNELDVGDCEALSYEQIQEKFP
.||.|||||  |  ||. |.|.  |.|.| | ||.| .... .|||  ...||.|||. ||||.|   .    ..  .|.|.|.|..| |..|...|.||
lylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeldipiikeprLrerdfgeweglpkeevkeefp

REFALRDQDKYRYRYPRGESYEDLVHRLEPVIMELE----RQDNVLVICHQAVSRC
 |.. ...||...|.|.|||..|.. |..|...||     ...|||...|..|.|.
eeyekwkrdkkefrppegesladvyeRvapfleelieakdkgenvlivsHggvlra
His_Phos_1 Histidine phosphatase superfamily (branch 1) 245-390 4.9e-36 117.0 In-house 2-157 (158) alignment 
Range on Protein: 245-390
Range on HMM: 2-157/158.0
IYLCRHGESICNMYGRIGGDSE--LSERGFEFARKLSEYISTQDLPGLKIWTSQLKRTKQTAELLDGPK----EQWRALNELDVGDCEALSYEQIQEKFP
.||.|||||  |  ||. |.|.  |.|.| | ||.| .... .|||  ...||.|||. ||||.|   .    ..  .|.|.|.|..| |..|...|.||
lylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeldipiikeprLrerdfgeweglpkeevkeefp

REFALRDQDKYRYRYPRGESYEDLVHRLEPVIMELE----RQDNVLVICHQAVSRC
 |.. ...||...|.|.|||..|.. |..|...||     ...|||...|..|.|.
eeyekwkrdkkefrppegesladvyeRvapfleelieakdkgenvlivsHggvlra
AAA_33 AAA domain 36-190 1e-14 45.1 Pfam-A 2-142 (143) alignment 
Range on Protein: 36-190
Range on HMM: 2-142/143.0
IALVGLPARGKTYIARKLARYLNWIGVNTKVfnvgeYRRNAVGaektfeFFHPDNKEATEARRKCAIAALQDVQKFLEEGGDaAVFDATNSTKERRQLII
. |||||. ||.. |..|.. | .. ... .     .||   |        ... .. |... ..  . .. ..| |..|.. ...|||| ..|.|. ..
vllvGlpGsGKstlaerllkklgyvrlsqdt.....lrrrlfg......tdqqsltdytrvlkrlyqilnklarkalsagrs.vivdatnlsreerarfv

DHCQPHSIKVFFIESICDDpELVDENIKAVKLSSPDYSDrATDEAIEDFKKRIEV
. .. .. .|  .   ... |.  |.... . .. | |. ...||......|.|.
klakrlgvpvrivylevpe.etlaeRlakRerngddrse.vpeealdrmlarfep
AAA_17 AAA domain 35-135 8.3e-10 30.2 Pfam-A 1-78 (121) alignment 
Range on Protein: 35-135
Range on HMM: 1-78/121.0
CIALVGLPARGKTYIARKLARYLNWIgvntkVFNVGEYRrnavgAEKTFEFFHPDNKEATEARRKCAIAALQDVQKflEEGGDAAVFDAtnstkerrqli
.||..| |. ||...|..||..|...     |.. ....      |.... .. ...|. .| ..   | | . ..  .....  |.|            
viaitGppGsGKsTlakeLaerlglp.....vlslddll.....reeglkelddgereskdadadllaaildglaa..kkdtlswvidg...........

I
 
a
subfamily_TIGAR_pd Subfamily TIGAR 244-396 1e-09 30.4 In-house 2-174 (222) alignment 
Range on Protein: 244-396
Range on HMM: 2-174/222.0
SIYLCRHGESICNMYGRIGGD--SELSERGFEFARKLSEYIStqDlPGL-KIWTSQLKRTKQTAELLDGPK--------EQWRALNELDVGDCEALSYEQ
.... ||||.. |  . . |   . |||.|.| | .... .|  . ...  | .| |.|.|||||.   .         |.   | | . |. |  ....
ilivVrhGetefnkekilqgqtdtpLsekGveQakrvakrLs..n.ekinyifsSdllRAkqTaeiilkalkekkreaverdkrLrEreyGvyeGvalde

IQEKFPREFalrdqDKYRYRYPRGESYEDLVHRLEPVIMEL-----ERQ------------DNVLVICHQAVSRCILAYFL
..|    .      .  .   . ||| | |  || . . ||     ...             .|||..|....|  |....
lrellkaag.....nvpsfvpegGesieqlelrlvaaleelcakilhleadkkkdgaegelthvlvvshglalrellnvlh
subfamily_PGAM_pd Subfamily PGAM 245-307 6.5e-09 27.4 In-house 3-67 (248) alignment 
Range on Protein: 245-307
Range on HMM: 3-67/248.0
IYLCRHGESICNMYGRIGG--DSELSERGFEFARKLSEYISTQDLPGLKIWTSQLKRTKQTAELL
. | |||||  |   .. |  | .|||.| | |.|.....  ..|   ...||.|||..||.|..
lvllRhGeselnkenkfcgwvDakLsekGkeeAkkagkalkqanlefdivytSvlkRaqqTlevi
subfamily_TFC7_pd Subfamily TFC7 260-388 1e-08 26.1 In-house 26-170 (255) alignment 
Range on Protein: 260-388
Range on HMM: 26-170/255.0
RIGGDSELSERGFEFARKLSEYISTQDLPGLKIWTSQLKRT----KQTAELLDGPKEQWRALNELDVGD-----CEALSYEQIQEKFPREFAlRDQDKYR
 |  |  |||||.| |..|..|... ||    | .| |.|     | .||.|. |    | . |    |      | .|.| .. .||.    .| .   
gidsdvPlserGveqakelaiylkkldlkpeaifssPlyrcletskpiaeeleiPvyvdrGvgewykpdrrPvilePasnevlskffPsvis.ldyestl

YRYPRGESYEDLVHRLE---PVIM-----ELERQDNVLVICHQAVS
   ..||. |.| .|..   || .     . . .. .|.. | |  
tpsekgeteeelyertkkfwpvfidrvekkfknvetilivthaatk
KTI12 Chromatin associated protein KTI12 36-163 3.3e-07 19.7 Pfam-A 4-118 (270) alignment 
Range on Protein: 36-163
Range on HMM: 4-118/270.0
IALVGLPARGKTYIARKLARYLNWigvntkvfnvgEYRRNAVGAEKTFEfFHPDNKEATEARRKCAIAALQDVQKFLEEGgDAAVFDATNSTKERRQLII
. | |||. ||. .|..||..|.            | |. .|  . ... .. |. . ... ..   .  ..|.. |..  .  . |..| .|  |  ..
vvltGlPssGKstvakeLakalee...........egrsvvvisdeslg.iekdsykdskkekalRsslrsavkrdLske.kvVIvDslnYikgfRyeLy

DHCQPHSIKVFFIESICDDPELVDENIK
  ..  ....  .. ...  .||  | .
clakeakttlcvvyvvapletlvkwnee
AAA_18 AAA domain 36-158 2e-06 17.1 Pfam-A 1-106 (129) alignment 
Range on Protein: 36-158
Range on HMM: 1-106/129.0
IALVGLPARGKTYIARKLARYLnwigvntkvfnVGEYRRNAVGAEKTFEFFHP-DNKEATEARRKCAIAALQDVQKFLEeggdaavfdatN---------
|...| |. ||| .|..||. |           .  .| .|   .  .|...  |.||  |....   ..|. ...  .           .         
IlitGtpGsGKtTlakeLaerl...........gdvlrdlakeegleeevddkidtkeskeldedkldelldkleenes...........elaegenvii

----STKERRQLIIDHCqphsikvffIESICDDPELV
    . .|...|.. ..         .   .|. || 
dghlaeleledlkdlkl.........vvLradpeela