Gene STS in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily STS
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP192_AA protein Get Run
AqueP192_AA_376-621 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_STS_pd Subfamily STS 387-637 1.4e-99 324.4 In-house 1-244 (245) alignment 
Range on Protein: 387-637
Range on HMM: 1-244/245.0
RRVFIFRHAERVDVTFGKqWIQlSFDaEGYYNRRNLNMPKELPKRRGGPQDFTKDSPITETGLFQARLTGEGMREQGIKIHHVFASPALRCIQTANAFLQ
|...|.||.||||..||| |.. ||| ||.|.|..||.|||||.|..|..|...|.|.||.| .||.|.|....|.||||.|.|.||.|||||||.|.|.
rtiyivRhgeRvdevfgk.Wlk.sfd.egkyerkdlnlpkelprrpdglkdyksDpPlterGviqAkllgraLleagikiehifcSPslrciqTaaailk

GMGdFHTKIKIENGLFEWLAWCHGEIPSFMHSEEILKFGLQIDPTYTSMVSMKDLKPNETHLEFYKRMYNITRLLLKNIgPSSGNVMIVGHAATLEACSR
|.|  ..|||.|.||.|||......||.....||. ||..|||..|....|...||..|.. |.|.|...... ..... |..||..||.|||||.|.||
glg.kkikikvepgllewlkldrkpipellspeelkkffpqidedYkpvlslselkskeseeelyeRikkvvkeiiekv.pedgniliVahaatldalsr

QLCGGQPRNAQELTKLVQKIPYCGVAVCQESGSgrNSTWDFIDPPVPPLTH
||.|..||....|.|||.|.|||..|...|. .  .. |.  |.....|..
qllglspresedlkklvikspycslakleenke..erkwkltdsgilsllk
subfamily_Cele-STS-like_pd Subfamily Cele-STS-like 388-637 1e-45 146.8 In-house 1-228 (229) alignment 
Range on Protein: 388-637
Range on HMM: 1-228/229.0
RVFIFRHAERVDVTFGKqWIQlSFDAEGYYNRRNLNMPKELPKRRggpQDFTKDSPITETGLFQARLTGEGMREQGIKIHHVFASPALRCIQTANAFLQG
.|...|.|||||  ||| ||. |.| |. |.  ..|.|||||||    . .  |.|.||.| ....|.| ..|..||.. .|| ||.||..||| . |.|
evvvirsaervdevfgk.Wik.sadletkyrpldinvPkelpkra...ksykldpPlteiGkiaskligRaLrdrgiepsvvFCSPdlrsvqtaalllkg

MGDFHTKIKIENGLFEwlawCHGEIPSFMHSEEILKFGLQIDPTYTSMvsmKDLKPNETHLEFYKRMYNITRLLLKNIgpSSGNVMIVGHAATLEACSRQ
.|   ..|..| ||.|     .   . ..  ... |.|  .| .|. .   |.|. .|.  .|..|. .  . ||...    .....| ....|| . |.
lGlkraaisvePgLle....yrkarevllppkafkklgypvdekYkPl...kelsmaeslsdfvariqaafkkllskv..eqklilvvadnvsleltrre

lcggQPRNAQELTKLVQKIPYCGVAVCqesgSGRNSTWDFIDPPVPPLTH
    . . ...|. |..| |.. | .     . ..  .  .| ||..|..
....dvesvddllvllkktpalsvviv....nlkkGearivdspvlllsk
0036777 Phosphoglycerate mutase-like 387-621 1.3e-32 105.7 In-house 3-222 (247) alignment 
Range on Protein: 387-621
Range on HMM: 3-222/247.0
RRVFIFRHAERVDVTfgkqwiqlsfdaegyynrrnlnmpkelpkrRGGPQDFtKDSPITETGLFQARLTGEGMREQGIKIHHVFASPALRCIQTANAFLQ
.|... ||.| .. .                               |  |.   |.|.||.|  ||...|| ..|.|... .|..||.||.||||...|.
krlyLvRHGetewna..............................egrfqgw.lDvpLtelGreqakalgellkelglpfdavysSpllRAiqTaeiile

GMGDFHTKIKIENGLFEW---------------------LAWCHGEIPSFMHSEEILKFGLQIDPTYTSMVSMKDLKPNETHLEFYKRMYNITRLLLKNI
..|  . ..... .| |.                      ||... ..  .   |.|   |..| ... .. .. |   |.  ....|...  . ||  .
alglsllpvvvdprLrErdyGalegltkaeiaekypeelvawwrdpydyrppllelllelllldllryallpldllpggEsladvvaRvlpaleellarl

GPSSGNVMIVGHAATLEACSRQLCGGQPRNAQELtklvqKIPYCGVAVCQESGSGR
 .. .||..|.|...| |. ..| | .. .. .|     ..|.... |..  ..| 
lkdgenvlvVsHggvlrallayllglsledilrl.....nlpngsitvleldddgk
0043909 Phosphoglycerate mutase-like 387-621 5.8e-31 100.2 In-house 3-226 (249) alignment 
Range on Protein: 387-621
Range on HMM: 3-226/249.0
RRVFIFRHAERVDVTFGKQwiqlsfdaegyynrrnlnmpkelpkrrggpQDfTKDSPITETGLFQARLTGEGMREQGIKIHHVFASPALRCIQTANAFLQ
.|... ||.| .. . |.                               |.   |||.||.|  |||..|| ..|.||....|..||..|.||||...|.
krlyLvRHGetewnaegrf..............................qg.wlDspLtelGreqaralgealkelgipfdavysSplkRAiqTaeiile

GMGDFHTKIKIENGLFEW------------------------LAWCHGEIPSFMHSEEILKFGLQIDPTYTSMVSMKDLKP-NETHLEFYKRMYNITRLL
..|  . ..... .| |.                        |.. .. .| ....   |.. | .|...... .  |  |  |.  ....|. .  . |
elgldklpvevdprLrErdfGalegltkaeiaekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppggEsladvvaRvlpaleel

LKNIGPSSGNVMIVGHAATLEACSRQLCGGQPRNAQELtklvqKIPYCGVAVCQESGSGR
|. . .. |||.||.|...| |. ..|.| ..... .|     ..|.... |.. ...|.
larllkdggnvliVaHggvlrallayllglsledilrl.....nlpngsitvlelddggk
0051064 Phosphoglycerate mutase-like 386-620 1.1e-29 96.5 In-house 3-222 (241) alignment 
Range on Protein: 386-620
Range on HMM: 3-222/241.0
PRRVFIFRHAERVDVTFGK--QwiqlsfdaegyynrrnlnmpkelpkrrggpqdfTKDSPITETGLFQARLTGEGMREQGIKIHHVFASPALRCIQTANA
..|... ||.|... . |.                                      |.|.||.|  ||| .|| ....|||. .|..||.||.||||..
mkrlyLvRHGesewnaegrlqg.................................wtDvpLtelGreqaralgerladlgikfdavysSpllRaiqTaei

FLQGMGDFHTKIKIENGLFEWL---------------------AWCHGEIPSFMHSEEILKFGLQIDPTYTSMVSMKDLKPNETHLEFYKRMYNITRLLL
.....|  . .......| |.                      ||....    ..  |.|.. |..  .. .... . |   |.  ....|. .  . ||
iaealglpllpvvvdprlrEidfgalegltleeiaekfpeelvawlrdpldvrppllelldlllllldlryagllddllpggEsladvaaRvlpaleell

KNIGPSSGNVMIVGHAATLEACSRQLCGGQPRNAQELtklvqKIPYCGVAVCQESGSG
 ..  . .||..|.|.... |. ..|.|  .  .  |     ..|...| |.  ...|
arllldgknvlvVsHggvirallayllglpleellrl.....nlpngsvtvleldddg
0048955 Phosphoglycerate mutase-like 388-619 2.3e-29 95.3 In-house 2-218 (240) alignment 
Range on Protein: 388-619
Range on HMM: 2-218/240.0
RVFIFRHAERVDVTFGKQWIqlsfdaegyynrrnlnmpkelpkrrggpqdfTKDSPITETGLFQARLTGEGMREQGIKIHHVFASPALRCIQTANAFLQG
|... ||.|... ..|. .                                  |.|.||.|  ||| .|| ....|||. .|..||.||.||||......
rlyLvRHGesewnaegrlqg...............................wtDvpLtelGreqaralgerLadlgikfdlvysSpllRaiqTaeiiaea

MGDFHTKIKIENGLFEWL---------------------AWCHGEIPSFMHSEEILKFGLQIDPTYTSMVSMKDLKPNETHLEFYKRMYNITRLLLKNIG
.|  . .. ....| |.                      .|....   ..   |.|.  |..  ... ... . |   |.  ....|. .  . ||..  
lglpllpvvvdprlrErdfgalegltldeiaekfpeelvlwlrdpldvrppllelldellllldlryalldedllpggEsladvaaRvlaaleellaral

PSSGNVMIVGHAATLEACSRQLCGGQPRNAQELtklvqKIPYCGVAVCQESGS
 ...||..|.|.... |. ..| |  .. . .|     .||...| |.  ...
kpgknvlvVsHggvirallayllglpleeilrl.....nipngsvtvlelddg
0037864 Phosphoglycerate mutase-like 386-618 9.6e-29 92.7 In-house 7-199 (211) alignment 
Range on Protein: 386-618
Range on HMM: 7-199/211.0
PRRVFIFRHAERVDVTFGKQWiqlsfdaegyynrrnlnmpkelpkrrgGpqdfTKDSPITETGLFQARLTGEGMREQGIKIHHVFASPALRCIQTANAFL
..|... ||.|... . |. .                           |      |.|.||.|  |||..|| ....|.....|..||.||.||||...|
mtrlyLvRHGetewnaegrlq...........................g....wldvpLtelGreqaralgealadlglpfdavysSpllRaiqTaeiil

QGMGDFHTKIKIENGLFEwlaWCHGEIPSFMHSEEILKFGLQIdPTYTSMVSMKDLKPNETHLEFYKRMYNITRLLLKNIGPSSGNVMIVGHAATLEACS
...|  . ..... .| |   ...|.     ..|   |..      .          . |.  ....|...  . ||..  .. .||..|.|...| |. 
ealglpllpvevdprlrE...rdfgalegltleeiaekypeel.vawlrdpydfrppggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrall

RQLCGGQPRNAQELtklvqKIPYCGVAVCQESG
..|.| .. .. .|     ..|...|.|.. ..
ayllglsleellrl.....nlpngsvtvleldd
0049178 Phosphoglycerate mutase-like 439-618 1.5e-26 85.9 In-house 25-218 (243) alignment 
Range on Protein: 439-618
Range on HMM: 25-218/243.0
TKDSPITETGLFQARLTGEGMREQGIKIHHVFASPALRCIQTANAFLQGMGDFHTKIKIENGLFEW---------------------LAWCHGEIPSFMH
  ||| ||.|  |||..|| ..|.|.|. .|..||..|.||||...|...|  . ..... .| |.                      || ..     . 
wtDspLtelGreqAralgellaelglkfdavysSplkRaiqTaeiilealglpllpvvvdprLrErdfGalegltkaeiaakypeelvawwrdpydarpp

SEEILKfgLQIDPTYTSMVSMKDLKPNETHLEFYKRMYNITRLLLKNIGPSSGNVMIVGHAATLEACSRQLCGGQPRNAQELTklvqkIPYCGVAVCQES
  ..|.  | .. ..  ....  |   |.  ....|. .  . ||...  . ..|..|.| ... |  ..|.| ..  .  |      .|...| |.. .
alllld..lllplldrlladldllpggEsladvaaRvlpaleellaellhdgktvlvVaHggvirallalllglpleellrln.....lpngsvtvleld

G
.
d
0035570 Phosphoglycerate mutase-like 388-620 9.8e-26 83.0 In-house 1-179 (219) alignment 
Range on Protein: 388-620
Range on HMM: 1-179/219.0
RVFIFRHAERVDVTfgkqwiqlsfdaegyynrrnlnmpkelpkrrggPQ---DftkDSPITETGLFQARLTGEGMREQGIKIHHVFASPALRCIQTANAF
|... ||.|... .                                 .    .   |.|.||.|  ||| .|| ....||.. .|..||.||.||||...
rlyLvRHGetewnl.................................egrlqg...dvpLterGreqaralgealadlgipfdavysSpllRaiqTaeii

lqgmgdfHTKIKIENGLFEWLAWCHGEipsfMHSEEILKF-G-----LQIDPTYTSMvsmkdlKPNETHLEFYKRMYNITRLLlknigPSSGNVMIVGHA
       . ...|. .| |. .         .. .|| .. .     .. || .. .         |.  ....|...  . |     .. .||..|.|.
.......glpveidprLrEidfgdleg....ltldeiaekypeelaawlrdpydyrp......pggEsladvvaRvlpaleel.....edgenvlvVsHg

ATLEACSRQLCGGQPRNAQELTklvqkIPYCGVAVCQESGSG
... |  ..|.| .. ..  |      .|...| | .  |.|
gvirallayllglpleeilrln.....lpngsvtvleldggg
0036887 Phosphoglycerate mutase-like 386-618 1.2e-25 82.7 In-house 1-187 (202) alignment 
Range on Protein: 386-618
Range on HMM: 1-187/202.0
PRRVFIFRHAERVDVTFGKQW--IqlsfdaegyynrrnlnmpkelpkrrggpqdftkDSPITETGLFQARLTGEGMReqGIKIHHVFASPALRCIQTANA
..|... ||.|... . |.    .                                 |.|.||.|  ||| .|| ..  |... .|..||.||.||||..
mtrlyLvRHGetewnvegrlqgdl.................................dvpLtelGreqaralgerla..glpfdavysSpllRaiqTaei

FLQGMGdfhTKIKIENGLFEwlaWCHGEIPSFMHSEEILKFGLQIDPTYTSMVSMKDLkPNETHLEFYKRMYNITRLLLKNIgpSSGNVMIVGHAATLEA
.....|    ..... .| |   ...|      ..|   |..   .  ..... .    . |.  ....|...  . ||.    ..|||..|.|...| |
iaealg...lpvivdprlrE...idfgalegltleeiaekypeelaawlrdpydfrpp.ggEsladvvaRvlaaleellarl..dggnvlvVsHggvlra

CSRQLCGGQPRNAQELTklvqKIPYCGVAVCQESG
. ..|.|  . ..  |     |.|...| |.. ..
llayllglsledllrlr....klpngsvtvleldd
0039931 Phosphoglycerate mutase-like 389-621 9.1e-25 79.8 In-house 2-179 (219) alignment 
Range on Protein: 389-621
Range on HMM: 2-179/219.0
VFIFRHAERVDVTfgkqwiqlsfdaegyynrrnlnmpkelpkrR---GGpqdftkDSPITETGLFQARLTGEGMREQGIKIHHVFASPALRCIQTANAFl
... ||.| .. .                                   |      |||.||.|  ||| .|| ....|... .|..||.||.||||... 
lyLvRHGetewnv..............................egrlqg......dspLterGreqaralgerlkdlglpfdavysSpllRaiqTaeii.

qgmgdfHTKIKIENGLFEwlaWCHGEIPSFMHSEEILKFGLQIDPTYTS-----MvsmkdlKPNETHLEFYKRMYNITRLLLKnigpsSGNVMIVGHAAT
      . ...|. .| |   ...|      ..|   |..  .   . .     .         |.  ....|.... . ||.      .||..|.|...
......glpveidprLrE...idfgdlegltleeiaekypeelaawlrdpydyrp......pggEsladvvaRvlpaleella.....genvlvVsHggv

LEACSRQLCGGQPRNAQELtklvqKIPYCGVAVCQESGsGR
. |  ..|.| ..  .  |     ..|...| | . .. |.
irallayllglsleeilrl.....nlpngsvtvleldd.gg
His_Phos_1 Histidine phosphatase superfamily (branch 1) 388-584 1.6e-22 73.2 Pfam-A 1-158 (158) alignment 
Range on Protein: 388-584
Range on HMM: 1-158/158.0
RVFIFRHAERVdvtfgkqwiqlsfdaegyynrrnL----NmpkelpkrRGGPQDftkdSPITETGLFQARLTGEGMREQGIKIHHVFASPALRCIQTANA
|... ||.|..                       .    .          | .|    .|.||.|  ||| .|. .......|..|..|| .|.||||..
rlylvRHGese.......................wnkegr........lqgwsd....vpLtekGreqarelgkkLkradlpidavytSplkRaiqTaei

FLQGMGdfhTKIKIENGLFEWLA--WchgeiPsFMHSEEILKFGLqiD--PTYTSmvSMKDLKPN--ETHLEFYKRMYNITRLLLKnIGPSSGNVMIVGH
.|....   ..|..|..| |. .  |        ...||. .     .    . .    |...|   |.  ..|.|. .. . |..    ...||.||.|
lleeld...ipiikeprLrerdfgew.....e.glpkeevkeefp..eeyekwkr..dkkefrppegesladvyeRvapfleelie.akdkgenvlivsH

AATLEAC
...|.|.
ggvlral
His_Phos_1 Histidine phosphatase superfamily (branch 1) 388-584 1.6e-22 73.2 In-house 1-158 (158) alignment 
Range on Protein: 388-584
Range on HMM: 1-158/158.0
RVFIFRHAERVdvtfgkqwiqlsfdaegyynrrnL----NmpkelpkrRGGPQDftkdSPITETGLFQARLTGEGMREQGIKIHHVFASPALRCIQTANA
|... ||.|..                       .    .          | .|    .|.||.|  ||| .|. .......|..|..|| .|.||||..
rlylvRHGese.......................wnkegr........lqgwsd....vpLtekGreqarelgkkLkradlpidavytSplkRaiqTaei

FLQGMGdfhTKIKIENGLFEWLA--WchgeiPsFMHSEEILKFGLqiD--PTYTSmvSMKDLKPN--ETHLEFYKRMYNITRLLLKnIGPSSGNVMIVGH
.|....   ..|..|..| |. .  |        ...||. .     .    . .    |...|   |.  ..|.|. .. . |..    ...||.||.|
lleeld...ipiikeprLrerdfgew.....e.glpkeevkeefp..eeyekwkr..dkkefrppegesladvyeRvapfleelie.akdkgenvlivsH

AATLEAC
...|.|.
ggvlral
0053607 Phosphoglycerate mutase-like 437-617 2.9e-21 68.4 In-house 22-178 (191) alignment 
Range on Protein: 437-617
Range on HMM: 22-178/191.0
DftkDSPITETGLFQARLTGEGMREQGIKIHHVFASPALRCIQTANAFlqgmgdfHTKIKIENGLFEWLAWCHgeipSFMHSEEILKFGLQIDPTYTSMV
    |.|.||.|  |||...| ..|.|.|. .|..||.||..|||...       . ..... .| |. .         .. ||. .   ..   .    
g...dvpLtelGreqaralaellaelglkfdavysSpllRarqTaeii.......glpvevdprlrEidfgdw....egltleelaekypeelaawlrdp

SMKDLKPNETHLEFYKRMYNITRLLLKnigpsSGNVMIVGHAATLEACSRQLCGGQPRNAQELTklvqkIPYCGVAVCQES
        |.  ....|...  . ||.      |||..|.|.... |  ..|.| .. ..  |      .|...| | . .
ldyrppggEsladvaaRvlpaleella.....ggnvlvVaHggvirallayllglpleellrln.....lpngsvtvleld
SH3_9 Variant SH3 domain 224-279 2.5e-17 51.5 Pfam-A 1-49 (49) alignment 
Range on Protein: 224-279
Range on HMM: 1-49/49.0
VLYPYTPRKEDELELVEDDYVFVATSdqgrtDSEGWYIGTSftTGCSGMYPGNYVE
.||.|.|. .|||.| ..|...|  .     ...||  |..  ||..| .| ||||
AlydyepkdddELslskGdvitvlee.....tedgWllGel..tGrtGlvPanyVe
subfamily_TFC7_pd Subfamily TFC7 435-589 4.3e-16 50.2 In-house 24-178 (255) alignment 
Range on Protein: 435-589
Range on HMM: 24-178/255.0
PQDFTKDSPITETGLFQARLTGEGMREQGIKIHHVFASPALRCIQTANAFLQgmgDFHTKIKIENGLFEWLAWC-HGEIPSFMHSEEILKFGLQ-IDPTY
..   .| |..| |. ||.  .. ... ..|   .|.||  ||..|...  .    ..  .... |. ||.    .  |.  .  |.. ||  . |.. |
ltgidsdvPlserGveqakelaiylkkldlkpeaifssPlyrcletskpiae...eleiPvyvdrGvgewykpdrrPvilePasnevlskffPsvisldy

TSMVSMKdlKPNETHLEFYKRMYNITRLLLKNIG---PSSGNVMIVGHAATLEACSRQLC
 | .  .  . .||  |.|.|. ..  . ....    .  . ..|| ||||  |  ..| 
estltps..ekgeteeelyertkkfwpvfidrvekkfknvetilivthaatkialGmsll
0050036 Phosphoglycerate mutase-like 440-594 1.5e-15 49.5 In-house 23-150 (171) alignment 
Range on Protein: 440-594
Range on HMM: 23-150/171.0
KDSPITETGLFQARLTGEGMreqgiKIHHVFASPALRCIQTANAFLqgmgdfhTKIKIENGLFEWlawCHGEIPSFMHSEEILKFGLqidptYTSMVSMK
 |.|.||.|. ||| .|| .     ....|..|| ||..|||...|        .. ....| |.   ..|.     ..|   |..      .  ..   
tdvpLtelgraqaralgell.....pfdavysSpllRArqTaelil.......lpvivdprLrEr...dfGawegltldeiaakype.....wlldlldl

DLKPNETHLEFYKRMYNITRLLLknigpssGNVMIVGHAATLEACSRQLCGGQPR
 .   |.  ....|...  . ||       |||..|.|.... |  ..|.|  . 
appggEsladvlaRvlpaleell.......gnvlvvaHggvirallalllglsle
0053031 Phosphoglycerate mutase-like 388-563 2.4e-12 40.0 In-house 6-161 (342) alignment 
Range on Protein: 388-563
Range on HMM: 6-161/342.0
RVFIFRHAERVD-VTFGKQWIQLSFDaegyynrrnlnmpkelpkrrggpqdftK--DSPITETGLFQARLTGEGMREQ---------GIKIHHVFASPAL
 ....|| .|   ... . ...  |                            .  ... |..|  ||. .|. .|.            ....|..|.  
vivlvRHGaRtPlskgpldplnewfy...........................pcgageLTplGreqayelGrrlrkrYlgllpstynpdevyvrssdvd

RCIQTANAFLQGM-GDFH-TKIKIENGlfewlawchgE----IPSFMHS-EEILKFGLQIDPTYtsMVSMKDLKPNETHLEFYKRMYNITRLLLK
|..|.| |||.|. .. . ... . .|               | ..  | . .| .. .  |..    ..|. . .|.. |...|.... . | |
RtlqSAqaflaGlfppegtpilnpllg..........wqpipihtepessdalllpnydpcpaf..dkllkealaseevkellerylellqklsk
0049059 Phosphoglycerate mutase-like 389-517 1.2e-11 37.4 In-house 47-177 (435) alignment 
Range on Protein: 389-517
Range on HMM: 47-177/435.0
VFIFRHAERVDVT----FGKQWIQLSFDAEGYYNrrnlnmpkelpkrrgGPQDFTKD-------SPITETGLFQARLTGEGMRE-----QGIKIHHVFAS
. .||| .|  .       ...... ...  |.|               || .| .|       .  |..|  ||. .|. .|.        . ..|..|
qvlfRHGaRtPtsklikklealwekllslltypn...............gplsflndwnyplgageLTplGreqayelGkrlrkrYgfLynpdevyvrss

PALRCIQTANAFLQGM-GDFHTKIKIENGLFEWLAWCHGEIPSFMH
.  |..|.| |||.|. .. . .....|.| ...     . .|. .
dvdRtlqSaqaflaGlfppeilgsqllnplnvyqpvpietvdsdnd
0047369 Phosphoglycerate mutase-like 389-507 1.2e-10 34.3 In-house 48-179 (438) alignment 
Range on Protein: 389-507
Range on HMM: 48-179/438.0
VFIFRHAERVDVTF----GKQWIQLSFDAEGYYNrrnlnmpkelpkrrgGPQDFTKDSP-------ITETGLFQARLTGEGMREQ----GIKIH-HVFAS
. .||| .|  . .      ....|  .| .|..               || .| .| .        |..|  ||.  |. .|.       . . .|..|
qvlfRHGaRtPtksklkkleplwellenattyps...............gplsflndwlgpcgagqLTplGreqayelGkrlrkrYglLnpedvlyvrss

PALRCIQTANAFLQGM-GDF-----------HTKIKIENGLFEWLAW
.  |..|.| |||.|. ..            . .| ....  ..| .
dvdRtlqSAqaflaGlfppegtgelapilwqpipihtipesddflln
0049226 Phosphoglycerate mutase-like 389-543 2.8e-10 33.1 In-house 7-167 (342) alignment 
Range on Protein: 389-543
Range on HMM: 7-167/342.0
VFIFRHAERV-----DVTFGKQWIqlsfdaegyynrrnlnmpkelpkrrggpqdftK---DSPITETGLFQARLTGEGMRE---------QGIKIHHVFA
....||..|      . .| ..|                                     ... |..|  ||.  |. .|.            .. .|..
qvliRHGdRtPlakgpldflnewf................................wgcglgeLTplGreqayelGrrlrkrYlgllpstynpdevyvrs

SPALRCIQTANAFLQGM-GDFH------------TKIKIENGLFEWLAWC--------HGEIPSFMHSEEILKFGLQIDPTYTSMVSMKDLKP
|.  |..|.| |||.|. .. .             .| .|.  ...|           . .. ... |||. .|  .| ... ..... .|..
sdvdRtlqSaqaflaGlfppeltpilvplldwqpipiitepesndtllllpydscpnfdkllkellkseevqlfleeildllkklskllglnl
0046349 Phosphoglycerate mutase-like 389-564 5e-10 32.2 In-house 11-203 (409) alignment 
Range on Protein: 389-564
Range on HMM: 11-203/409.0
VFIFRHAERVDVTFgkqwiqlsfdaE-----------GyynrrnlnmpkelpkrrggpqDF-TKDSPITETGLFQARLTGEGMRE----QGI--------
...||| .|  .                                                . ..... |..|  ||. .|. .|.    .|.        
qvlfRHGaRtPtkk...........lsflpnwpginwt.....................ngpcgagqLTplGreqayelGkrlrkrYvdlgLlpsnslyn

-KIHHVFASPALRCIQTANAFLQGMG-DFHTKIKIENGLFEWLAWCHGEIPSFMHS------EEILKFGLQIDPTYTSM--------VSMKDLK------
 ....|..|.  |..|.| |||.|.  . . .| . .    . . ... . ..         ...| .. .  |.. ..          ...        
pdeiyvrssdvdRtlqSAqaflaGlfpplggeivpllrqdlldppfqpipidtvpiseddalddtllppdslcpaldkllkenlkslsevleflvdeall

---PNETHLEFYKRMYNITRLLLKN
    .... ...|...... . |..
dlelldetkdllkklaerlnselpg
0048946 Phosphoglycerate mutase-like 377-492 2e-09 29.9 In-house 30-159 (447) alignment 
Range on Protein: 377-492
Range on HMM: 30-159/447.0
ESPPAVPQGPRRV---FIFRHAERVDV---TFGKQWIQLSFD-AEGYYNRRNLNMPKELPK--------RrggpqdfTKDSPITETGLFQARLTGEGMRE
. |..||.| . .    .||| .|  .   ..| ...   .. | ... ...|..... ..                 . .  |..|  |..  |. .|.
gipepvpegcelkqvqvlfRHGaRtPtkkylkgleplldllknanvlelggdlsflndwkyqlkneplwp.......cglgqLTplGreqlyelGkrlrk

Q------GIKIHHVFASPALRCIQTANAFLQGMGDFH
         .  .|..|.  |..|.| |||.|. .  
rYlgllpnpseiyvrssdvdRtlqSaqaflaGlfppe
2_5_RNA_ligase2 2'-5' RNA ligase superfamily 79-207 3.5e-09 25.2 Pfam-A 17-141 (153) alignment 
Range on Protein: 79-207
Range on HMM: 17-141/153.0
GRNGAHKSFPHVTLCQFFKVEDSLapyvvHALKTSFTSMI-KDAPAEVKLKRFTT---QGYiGLFLEDDIATWFREFTKSFAAEVKQHGVTVEP-HRRQL
.  ....  ||.||.  |. ...|      .|.   .  . . .| || |... .   ...  ..||..  . .... .. .......|  ..  .. . 
ydkayprwppHiTLlypfvepedl.....qdlaellsrlaaetepfevrldgvgvFehkks.vvylevspseslsaLraallealpeaglkedstgeftP

HITMAHQYLPEHHKTLEDLAmslVDPTQPAKWEI
|.| |..  .. .| | . .    .  .|...|.
HlTiaqsedstsakellekl...agalpplefev
0048439 Phosphoglycerate mutase-like 390-497 9.7e-09 28.1 In-house 14-114 (391) alignment 
Range on Protein: 390-497
Range on HMM: 14-114/391.0
FIFRHAERV---DVTF--GKQWIQlsfdaegyynrrnlnmpkelpkrrggpqD----FTKDSPITETGLFQARLTGEGMREQ-------------GIKIH
 .||| .|    ....   . . .                            .     ..... |..|  |.. .|. .|.                ...
vlfRHGaRtPtssypnkldpllnk............................llpngpcglgeLTplGreqlyelGrrlrkrYvdlgllpskytlnpsev

HVFASPALRCIQTANAFLQGMGDfHTKIKI
.|..|.  |..|.| |||.|. . ......
yvrssdvdRtlqSAqaflaGlfp.plgltv
SH3_1 SH3 domain 223-274 2.5e-08 22.5 Pfam-A 1-47 (48) alignment 
Range on Protein: 223-274
Range on HMM: 1-47/48.0
KVLYPYTPRKEDELELVEDDYVFVATSDQGrtdseGWYIGTSFTTGCSGMYP
..||.|..|..||| . ..| ..|   . .     ||. | . .||  |..|
iAlYDYearesdELsfkkGDviivleksed.....gWwkgrlkgtgkeGliP
subfamily_TIGAR_pd Subfamily TIGAR 438-504 3.4e-08 25.4 In-house 21-86 (222) alignment 
Range on Protein: 438-504
Range on HMM: 21-86/222.0
FTKDSPITETGLFQARLTGEGMREqgIKIHHVFASPALRCIQTANAFLQGMGDFHTK-IKIENGLFEW
.  |.|..|.|  || .... . .   ||...|.|. ||  |||.. |. . . . . ..... | |.
gqtdtpLsekGveQakrvakrLsn..ekinyifsSdllRAkqTaeiilkalkekkreaverdkrLrEr
subfamily_PGAM_pd Subfamily PGAM 440-503 4.3e-07 21.5 In-house 23-86 (248) alignment 
Range on Protein: 440-503
Range on HMM: 23-86/248.0
KDSPITETGLFQARLTGEGMREQGIKIHHVFASPALRCIQTANAFLQGMGDFHTKIKIENGLFE
.|  ..|.|  .|. .|. ........  |..|   |..||... |. .      .. .  | |
vDakLsekGkeeAkkagkalkqanlefdivytSvlkRaqqTlevileeldqekiPvektwrLnE
SH3_2 Variant SH3 domain 222-280 3.5e-06 15.2 Pfam-A 2-54 (55) alignment 
Range on Protein: 222-280
Range on HMM: 2-54/55.0
YKVLYPYTPRKEDELELVEDDyVFVATsdqGRTDSEGWYIGTSftTGCSGMYPGNYVEK
....  |.. .. ||.. ..| |. ..   |...|.||..|..  .|  |  | ..||.
vraiedyvgedpseLsfkkGd.vikvl...gskesdgwwlgev..gGrvGlfPsslvee
CDC37_N Cdc37 N terminal kinase binding 302-363 5.4e-06 14.2 Pfam-A 16-77 (177) alignment 
Range on Protein: 302-363
Range on HMM: 16-77/177.0
EEVKTPPNVLTKSIFKARNSTIRREDQQSYSSSVGLLPERKNVEELYAKVKPRKKRNEESQS
. | . ||| .||.....   |  . .|  .    |  |.|  ..|...|. . .. .|...
sDvevHPNvDkkSfirwkqqaihekreqrkkeieelekelkinkkllervdkllselkeeee
DUF3425 Domain of unknown function (DUF3425) 219-288 7.7e-06 12.3 Pfam-A 85-135 (136) alignment 
Range on Protein: 219-288
Range on HMM: 85-135/136.0
SevykvlypytprkedelelVEDDYVFVATSDQGRTDSEGWYIGTSFTTGCSGMYPGNYVEKVKDSDCWT
.                    ....|... .|.. .| |.| .. || .  . .. |. || ......|.
e...................egtlivwspagdetpwdlenWeltesFlekypwlvdgcdvellrstnrwr