Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
| Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
|---|---|---|---|---|---|---|---|---|---|
| subfamily_ILKAP_pd | Subfamily ILKAP | 5-322 | 8.5e-150 | 490.8 | In-house | 2-292 (293) | alignment | ||
Range on Protein: 5-322
Range on HMM: 2-292/293.0
RYQLRGYHGERRGEREEMQDSHVIINDMMEQfPTLSNSPVSSVSYYGVFDGHSGSRASEFAAGNLHRVIVNKFPKEDVSA--QSIKRCLVDSFKKTDSDF
.|.|.|...||.||||||||.|||..|..|| ..|..|.||.||||.|||||.||||||||| .||..|..|.||.|||| ..||.||||||||||..|
lyklkgayaerkGereemqdahviledldeq.lrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeef
LSLAAKATPSWKDGSTVAIIMAMDNVLYSGNLGDSKSVMYRRSDEGDTggeppVISVPLTKDHTSAsvsyifdydffiifcffQLEERKRIEKSGGFVRE
|.||.||.|.||||||.......|||||..||||||.|..|...|||. ..||.||||||.. ..||||||.|.||.||.
LklaskakPvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdk.....iasvvLtkdhtpv.................kyeerkriqkaGgvvrd
GRIMGIMEVSRSIGDGRFKGCGLIATPHVSRCELTENDLFVVVACDGLWNVFKMDEVAKFILGVVNDEsiqkpgEDDRLIQGTEVVSDREYRFEVACNRL
||..|..||||||||||||..|.|.||.|..|||||||||||.||||||.||..|||.|||| |..|| |||| |...|..|..|.|||||||||
grvlGvlevsrsiGdgrfkrlGvistPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvlede......eddrkikeeekkskeevrfevacnrl
AVEAVKRGCTDNVTVLIVDI
|.||||||..||||||.|.|
aseavkrgssdnvtvllvki
|
|||||||||
| 0034914 | PP2C-like | 6-322 | 1.1e-56 | 184.9 | In-house | 19-290 (295) | alignment | ||
Range on Protein: 6-322
Range on HMM: 19-290/295.0
YQLRGYHGERRGEREEMQDSHVIINDMMEQFPTlsnspvssVSYYGVFDGHSGSRASEFAAGNLHRVIVNKFPK----EDVSAQSIKRCLVDSFKKTDSD
..|| .. .| |....|..... ... ... ....||||||.|..|.|.|. .|.. ... . | . | .|...|...|...| .
lllrvgvasdqGrrksneDavlvvlnllslled........lllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadee
FLSLAAKATPSWKDGSTVAIIMAMDNVLYSGNLGDSKSVMYRRSdegdtggeppvISVPLTKDHTsasvsyifdydffiifcFFQLEERKRIEKSGGFVR
.|.|| . . |.|. ... .| || .|.|||. |..|. |.||.||. . . .||.||...||.|.
llelallrpelagsGtTavvalirgnklyvanvGDSravllrng...........elvqltvdhk.................pvnelererilsaggavs
EGRIMGIMEVSRSIGDGRFK--------GCGLIATPHVSRCELT-ENDLFVVVACDGLWNVFKMDEVAKFILGVV----Ndesiqkpgeddrliqgtevv
||..|.. |.|..|| ..| . ...|.|.|. ||| |.| |...|.||||.|. .|..... .. .
hgrvngvlavtRalGdfdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgld....................
sdreyrFEVACNRLAVEAVKRGCTDNVTVLIVDI
|.|...|. .|..||..||.||..|..
......leeaaeeLvdlAlargsrDNiTvvvvrl
|
|||||||||
| PP2Cc_SM00332 | 11-320 | 8.1e-55 | 179.1 | In-house | 11-274 (274) | alignment | |||
Range on Protein: 11-320
Range on HMM: 11-274/274.0
YHG--ERRGEREEMQDSHVIINDMMeqfptlsnsPVSSVSYYGVFDGHSGSRASEFAAGNLHRVIVNKFPKEDV-SAQSIKRCLVDSFKKTDSDFLSLAA
.| . |.|..|.| ||...|. . ......||||||.||....|.. .|.. . .. |.. . ......| ..|..||...| .
sygkssmqgwrksmeDahvvvvdlv.........eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeq
KATP-SWKDGSTVAIIMAMDNVLYSGNLGDSKSVMYRRSDegdtggeppviSVPLTKDHTSasvsyifdydffiifcfFQLEERKRIEKSGGFVREGRIM
. . .. |||. ... .. || |.|||. |..| .. .|.|..||. .. .|||||.|.||.|. ||.
skelenalsGstavvallkkedlyvanvGDSravlcrngk...........avqlsvdhkp.................edederkRikkaggvvekgrvn
GIMEVSRSIGDGRFK------GCGLIATPHVSRCELTENDLFVVVACDGLWNVFKMDEVAKFILGVVNDEsiqkpgeddrliqgtevvsdREYRFEVACN
| .|||..||. .| ...|.|.|. ..||..| |...|.||||.|.. .|| ... . . . . . |..
gglavsrafGdhflkknkklkepyitaepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakg....................ktndpqeaae
RLAVEAVKR-GCTDNVTVLIV
.|. || .| |..||.||..|
lldeeairrggseDniTvvvv
|
|||||||||
| 0049733 | PP2C-like | 14-321 | 1.1e-42 | 139.0 | In-house | 9-232 (235) | alignment | ||
Range on Protein: 14-321
Range on HMM: 9-232/235.0
ERRGE-REEMQDSHVIindmmeqfptlsnspvsSVSYYGVFDGHSGSRASEFAAGNLHRVIVNKFPKedVSAQSIKRCLVDSFKKTDSDFLSLAAKATPS
..| |....|.... ......|.|||.|..|.|.|...|...... . . . .....|...|..... .|.|| . .
sdigrvrkvneDavlv.................glllfavaDGhgghaagevasellvetllellle..lllldleealrkaflaaneallelalaspel
WKDGSTVAIIMAMDNVLYSGNLGDSKSVMYRrsdE-GdtggeppviSVPLTKDHTSAsvsyifdydffiifcffQLEERKRIEKSGGFVregRIMGIMEV
. |.|..... .. || |.||| ...| . |.||.||. . . .||.||.. ||.| |..|. .
agmgtTavvalldggklyvanvGDsrayllr...dgk.........lvqltedhspv.................nelerqriitaggav...rvpgrlal
SRSIGDGRFKgcgliatPHVSRCELTENDlFVVVACDGLWNVFKMDEVAKFILGvvNDEsiqkpgeddrliqgtevvsdreyrfEVACNRLAVEAVKRGC
.|..|| .| |.|...||...| |...|.||||.|. .|..... . .| | |..||. .|..||
tralGdlllk.......pdvtvlelepgd.flllasDGlwdvlsdeeivdllrs..ldl.........................eeaaerlvelalargg
TDNVTVLIVD
.||.||..|.
rDNiTvvvvr
|
|||||||||
| subfamily_LRR-PP2C_pd | Subfamily LRR-PP2C | 16-270 | 7.3e-30 | 97.1 | In-house | 14-227 (255) | alignment | ||
Range on Protein: 16-270
Range on HMM: 14-227/255.0
RGEREEMQDSHVIindmmeqFPTLSNSPVSsvSYYGVFDGHSGSRASEFAAGNLHRVIVNKFpkeDVSAQSIKRCLVDSFKKTDSDFlslaaKATPsWKD
| | |.|. || . . . . . || .||||.|..|..||. .|.... ... |. . ...| ...|... . . |
iGrrptmedelvi.......yGsfrdksde..dyyalfdGhgGraaakfaseelykilaell...dlnnanPvkslkkaykeistqi.....serp.kfi
GSTVAIIMAMDNVLYSGNLGDSKSVMYrrsdegdtggeppvisvplTKDHTSASVSyiFDYDffiifcFFQLEERKRIEKSGGFVREG----RIMGIMEV
|.| | .. ... | |.|||. |. || |. .| .|. . .|.|||.. ||.| .. |. | . |
GttaasvliiedkvyianvGdsrvvlc...................qkdgtakrls..ldhk......PseeseekriselGGtvvstvvtsrvnGtlav
SRSIGDGrFKGCGLIATPHVS-RCELTENDLFVVVACDGLWNVFKMDEVAKFILGVVNDE
||..|| | ... |..| | ...| |...||||.|.. .| . ..|. . |
sralGds.flePfvvpdPdlsqsleiskkdkflilacdGiwdlisdeeaveivagisdpe
|
|||||||||
| subfamily_PPM1L_pd | Subfamily PPM1L | 17-267 | 5.9e-26 | 84.3 | In-house | 14-236 (269) | alignment | ||
Range on Protein: 17-267
Range on HMM: 14-236/269.0
GEREEMQDSHVIINDMMEQfptlsnspvSSVSYYGVFDGHSGSRASEFAAGNLHRVIVNKF-----PKEDVSAQSIKRCLVDSFKKTDSDFLSLAAKATP
| |..|.| | .|. .. . |...||||| | |.||| | . | ||. ||. . .. |.| | ..| | .|.
Grrprmedrfeieediknk.........tgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakraed
swKDGSTVAIIMAMDNVLYSGNLGDSKSVMYrrsdegDTGGeppvISVPLTKDHTSasvsyifdYdffiifcffQLEERKRIEKSGGFVR---EGRIMGI
|.|. | . .. | |.|||. |.| |. | ...||. || . |..|||||.|.|||. |. |.
..iaGttalialvqesdlivanvGdsrGvly......dkrG....kaiplsfdhkp........q.........qvkerkrikkaGGfiafrGvwrvaGv
MEVSRSIGDGRFKGCGL-IATPHVSRCELTEN-DLFVVVACDGLWNVFKMDEVAKFILGVV
. .||..|| .| | ||.| . .| . |...|.||||. | .| .||. .
latsralGdyplkdknlviadpdiltfdlddhkpeflilasdGlwdtfsneeavrfikerl
|
|||||||||
| PP2C | Protein phosphatase 2C | 187-315 | 6.7e-26 | 84.4 | Pfam-A | 145-255 (255) | alignment | ||
Range on Protein: 187-315
Range on HMM: 145-255/255.0
LEERKRIEKSGGFVR-EGRIMGIMEVSRSIGDGRFKG---CGLIATPHVSRCELTENDLFVVVACDGLWNVFKMDEVAKFILGVVNDESiqkpgeddrli
.||.|||..||.| .||. | ..|||..|| ..| . .| |.|. .|||.| |...|.||||.|.. .|.. .. .....
edEreRIeeaggsvsnngrvngsLavsRalGdfelkpkeeqlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkk...........
qgtevvsdreyRFEVACNRLAVEAVKRGCTDNV
. |...|. ||..||..||.
...........spmeaaeelvdeaiargsedni
|
|||||||||
| PP2C | Protein phosphatase 2C | 187-315 | 6.7e-26 | 84.4 | In-house | 145-255 (255) | alignment | ||
Range on Protein: 187-315
Range on HMM: 145-255/255.0
LEERKRIEKSGGFVR-EGRIMGIMEVSRSIGDGRFKG---CGLIATPHVSRCELTENDLFVVVACDGLWNVFKMDEVAKFILGVVNDESiqkpgeddrli
.||.|||..||.| .||. | ..|||..|| ..| . .| |.|. .|||.| |...|.||||.|.. .|.. .. .....
edEreRIeeaggsvsnngrvngsLavsRalGdfelkpkeeqlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkk...........
qgtevvsdreyRFEVACNRLAVEAVKRGCTDNV
. |...|. ||..||..||.
...........spmeaaeelvdeaiargsedni
|
|||||||||
| subfamily_PPM1A_pd | Subfamily PPM1A | 188-321 | 4.5e-24 | 78.3 | In-house | 160-279 (282) | alignment | ||
Range on Protein: 188-321
Range on HMM: 160-279/282.0
EERKRIEKSGGFVREGRIMGIMEVSRSIGDGRFKG--------CGLIATPHVSRCELTENDLFVVVACDGLWNVFKMDEVAKFILGVVNDE-S---Iqkp
.|.||||. ||.| .|..| . |||..|| .| ..| |.| .| .|.| |.|.||||.| | . .||.... .. .
kEkkRieqAGGsvvvsRvnGaLAvsRalGDyeykeeeekkaeeqlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleev...
geddrliqgtevvsdreyrfevaCNRLAVEAVKRGCTDNVTVLIVD
...| .| ..| .||..||.|
.......................akalvdkalekgsrDNlsvlvvl
|
|||||||||
| PPM_PTC7 | 188-315 | 8.1e-24 | 77.4 | In-house | 147-259 (259) | alignment | |||
Range on Protein: 188-315
Range on HMM: 147-259/259.0
EERKRIEKSGGFVR---EGRIMGIMEVSRSIGDGRFKG-----CGLIATPHVSRCELTENDLFVVVACDGLWNVFKMDEVAKFILGVVNDEsiqkpgedd
.||.|||..||.| .||. | .|||..|| ..| . ..|.|..| ...|.| |...|.||||.|. .|.. .. .....
dEreRiegaggsvsnvgngrvngvlavsRafGdfelkpketeeqlvsaePdisstkideedefliLasdGlwdvvsdqeavdlvrselskk.........
rliqgtevvsdreyRFEVACNRLAVEAVKRGCTDNV
. |...|. ||..||..||.
..............dpmeaaeklvdeaiargsedni
|
|||||||||
| subfamily_Dicty-PPM1L-like_pd | Subfamily Dicty-PPM1L-like | 46-321 | 3.5e-23 | 74.9 | In-house | 36-302 (305) | alignment | ||
Range on Protein: 46-321
Range on HMM: 36-302/305.0
SVSYYGVFDGHSGSRASEFAAGNLhRVIVNKFPKEDVSAQSIKRCLVDSF-----KKT--DSDFLSLAAKATPSWKDGSTV-----AIIMAMDNVLySGN
|..||||||.| .|.|.. .| ||||. ||. .| | ||. |.. ..| ||. . . | |.|. ..|. .... . .
elslfGvfdGhnGdiaaeyvkkkl.veivnkyvkenkvGysaknlnvddlpleaiksaslstdkssldsaesdnkkaGttlngssasvilererti.vst
LGDSKSVMYrrsdEGDTGGEPPVISVPLTKDHTsaSVSYiFDYDFFIIFCFFQLEERKRIEKSGGFV-REGRI--MGIMEVSRSIGDGRFKgCgLIATPH
.|...|. | . .| | | . . .. . |. |.| ||| .. . |.. .....|||.||. | . |.. .
asdtevvls....sGaiaeglsiinsPkgvgfd..spgw.mkfnhlynqnnfldeiririeslqaalynygellvnrllkksrskGdknlk.e.lviPnn
VSRCEL--TENDLFVVVACDGLWNVFKMDEVAKFILGVVNDESIQKpgeddRLiqgtevvsdrEYRFEVACNRLAVEAVKRGCTDNVTVLIVD
| || |.|.| ||||.|.. ..| .... ...|.|.|| .. |. |. .. . |||||| ||.|..|.
dspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqk.....ki..........ewdfneisrviveeavkrgsgDnitlviik
|
|||||||||
| subfamily_PPM1E_pd | Subfamily PPM1E | 16-144 | 1.7e-22 | 72.9 | In-house | 12-131 (265) | alignment | ||
Range on Protein: 16-144
Range on HMM: 12-131/265.0
RGEREEMQDSHVIINDMMEQFPTlsnSPVSSVSYYGVFDGHSGSRASEFAAGNLHRVIVNKFPKEDVSAqsikRCLVDSFKKTDSDFLSLAAKAtpSWKD
...| | | ||...|. | | . . ....|||||.|. |...|| .||...|.. .. .| . | ..||.||. ||. |.. ..|
knkrrkmEDrhvaledlnelfel...kdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa....ealkeafkltDerflqkaere..klks
GSTVAIIMAMDNVLYSGNLGDSKSVMYRR
||| ... . || . ||||.... |
GstavvvliekdqlyvaWlGDsqallvrk
|
|||||||||
| PPM_PTC7_SpoIIE | 14-279 | 9.1e-22 | 71.0 | In-house | 7-221 (230) | alignment | |||
Range on Protein: 14-279
Range on HMM: 7-221/230.0
ERRGEREEMQDSHVIINDMMEQfptlsnSPVSSVSYYGVFDGHSGSRasEFAAGNLHRVIVNKFpKEDVSaqSIKRCLVDSFKKTDSDF--Lslaakatp
. .| |..| |.|.. .... |. ... ..|..||| |. .|.| |. .. . ... . . .| ... . . |.
aaqgarksmedahispanseks......sggrlalvvgdvdGhGgra..alamgllrtalrela.fagle..kpeeilrrlnlalaadlede........
SWKDGSTVAIIM--AMDNVLYSGNLGDSKSVMYRRsDEGdtggeppvisvpltkdhtsasvsyifdydffiifcffqleERKRIeKSGGFVR----EGRI
.. |.|. .. ... || |.||| ...| |.| ||.|| ..||... .||.
psssgaTavvalidpstgklyvanaGdsppllvrd.dgg........................................ereri.vagglpslGilpgrv
MGIMEVSRSIGDGRFKG--CGLIATPHVSRCELTENDLFVVVACDGLWNVFKMDEVAKFILGVVNDESIQKPGEDD
| .||...|| .. | |. |. || ..| |...|.||||.| .|.. ... ... .. .|||
fgvlavslapGdllllytDGvveaepdtsdgelfgkdeflilasdglwdvlspqelvdlvrdelekpaaeglleDD
|
|||||||||
| PP2C | Protein phosphatase 2C | 14-168 | 3.3e-21 | 69.0 | Pfam-A | 7-143 (255) | alignment | ||
Range on Protein: 14-168
Range on HMM: 7-143/255.0
ERRGEREEMQDSHVIINDMMEQfptlsnSPVSSVSYYGVFDGHSGSRASEFAAGNLHRVIVNKFPKEDVSaqSIKRCLVDSFKK-TDSDFLSLAAKAtPS
| .| |..| |.|......... |. |||....||||| |..|...|. .|. .. .. ... ...| .|| . ||. . | .|..
elqgarksmedahialknleks......sgkssvaffavfdghggreaakyarehleeilkeqksflele..kvekalrksfladtdeelksskant.ep
WKDGSTVAIIMAMDNVLYSGNLGDSKSVMYRRSDEGdtggeppvisVPLTKDHTSA
.| ||| ... .. || |.|||. |. |.... . ||.||. .
sksGstavvalirgkklyvAnvGDSravLcrkdnak..........keltedHkps
|
|||||||||
| PP2C | Protein phosphatase 2C | 14-168 | 3.3e-21 | 69.0 | In-house | 7-143 (255) | alignment | ||
Range on Protein: 14-168
Range on HMM: 7-143/255.0
ERRGEREEMQDSHVIINDMMEQfptlsnSPVSSVSYYGVFDGHSGSRASEFAAGNLHRVIVNKFPKEDVSaqSIKRCLVDSFKK-TDSDFLSLAAKAtPS
| .| |..| |.|......... |. |||....||||| |..|...|. .|. .. .. ... ...| .|| . ||. . | .|..
elqgarksmedahialknleks......sgkssvaffavfdghggreaakyarehleeilkeqksflele..kvekalrksfladtdeelksskant.ep
WKDGSTVAIIMAMDNVLYSGNLGDSKSVMYRRSDEGdtggeppvisVPLTKDHTSA
.| ||| ... .. || |.|||. |. |.... . ||.||. .
sksGstavvalirgkklyvAnvGDSravLcrkdnak..........keltedHkps
|
|||||||||
| subfamily_PPM1G2_pd | Subfamily PPM1G2 | 17-145 | 4.9e-21 | 67.9 | In-house | 28-145 (287) | alignment | ||
Range on Protein: 17-145
Range on HMM: 28-145/287.0
GEREEMQDSHVIINDmmeqfpTLSNSPVSSVSYYGVFDGHSGSRASEFAAGNLHRVIVNkfpKEDVSAQSIKRCLVDSFKKTDSDFLSLaaKATPSWKDG
| | .| |.|.. |. |..| .|.....||||| |......|. .|...|.. |.. . ......| |.|..||...|. ... . |
GyrlnmeDahilene......lleksddkslalfavfDGhGGakvakyagkklikkiak...kksfkegaleqilkdafletDeellkd..eklkdesaG
STVAIIMAMDNVLYSGNLGDSKSVMYRRS
|| ... ... || .| |||..|. ..
stavvvlikeeklyvanaGDsravlsskg
|
|||||||||
| PPM_PTC7 | 14-167 | 1.6e-20 | 66.7 | In-house | 7-143 (259) | alignment | |||
Range on Protein: 14-167
Range on HMM: 7-143/259.0
ERRGEREEMQDSHVIINDMMEQfptlsnSPVSSVSYYGVFDGHSGSRASEFAAGNLHRVIVNKFPKEDVSaqSIKRCLVDSFKK--TDSDFLSLAAKAtP
. .| |..| |.|.. .... . |. .||....||||| |..|...|. .|. .. .. .|. ...| .|| . ||. . | .|..
afqgfrksmedahialanless......sgkdsvaffavfdghggreaakyarehleeilkerksfeele..klekalrksflaldtdeelksseant.e
SWKDGSTVAIIMAMDNVLYSGNLGDSKSVMYRRSDEGdtggeppvisVPLTKDHTS
... ||| ... .. || |.|||. |. |. .. ..||.||.
pstsGstAvvalitgsklyvAnvGDSravLcrsgnav..........kqltedHkp
|
|||||||||
| subfamily_PPM1G_pd | Subfamily PPM1G | 111-267 | 3.8e-19 | 62.0 | In-house | 292-429 (473) | alignment | ||
Range on Protein: 111-267
Range on HMM: 292-429/473.0
PSWKDGSTVAIIMAMDNVLYSGNLGDSKSVMYRRsdegdtggeppvisvpltkdhtsasvsyIFDYDFFIIFCFFQLEERKRIEKSGGFVR-EGRIMGIM
| . |.| ... .. |. | |||..|. | |. . .|..|||| || | .||. | .
pGedsGttAvvaLlkekklivAnaGDsRcvlsrn............................GkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGL
EVSRSIGDGRFKGCG--------LIATPHVSRCELTENDLFVVVACDGLWNVFKMDEVAKFILGVV
.|| .|| .| . | | . .|||.| |.|.||||.||| . .|| |. .
nlsRAlGDhaYkkneeLplkeqmisAlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvrakl
|
|||||||||
| subfamily_PPM1A_pd | Subfamily PPM1A | 15-145 | 4.4e-19 | 61.9 | In-house | 19-145 (282) | alignment | ||
Range on Protein: 15-145
Range on HMM: 19-145/282.0
RRGEREEMQDSHVIINDMMeQfptLsnspvSSVSYYGVFDGHSGSRASEFAAGNLHRVIVN--KF---PKEDVSAQSIKRCLVDSFKKTDSDFLSLAAKA
.| | || |.|... .. . | .. |.. |||||.||....... .|.. |.. .. .|. .....| | ..| ..|.. .| ...
mqgwrvemEDahtvvaslg.a...l.....kdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairelstdl
TPSWKDGSTVAIIMAMDNVLYSGNLGDSKSVMYRRS
. . | |||. .. .. |. |||||..|..|
ktadksGsTavtvlvsekhliianlGDsRavlcrng
|
|||||||||
| subfamily_PPM1E_pd | Subfamily PPM1E | 188-274 | 2.1e-17 | 56.2 | In-house | 147-235 (265) | alignment | ||
Range on Protein: 188-274
Range on HMM: 147-235/265.0
EERKRIEKSGGFVR---EGRIMGIMEVSRSIGDGRFKGCgLIATPHVSRCELTENDLFVVVACDGLWNVFKMDEVAKFILGVVNDESIQK
.|.||||. ||.| . |. |.. |||.||| . | ... . |...||.... ....||||||.|.. .|| | . ..|.. ..
dEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklkpy.vsgeadvaeveldgseeylilacDGlwDvvneeevvklveefladgaedl
|
|||||||||
| subfamily_PPM1D_pd | Subfamily PPM1D | 16-169 | 9.9e-17 | 54.0 | In-house | 10-157 (309) | alignment | ||
Range on Protein: 16-169
Range on HMM: 10-157/309.0
RGEREEMQDSHVIINDMMEQFPtlsnspVSSVSYYGVFDGHSGSRASEFAAGNLHRVIVNKFPKEDVSAQSIKRCLVDSFKKTDSDFLSLAAKATPSW--
.|.|. |.| .| . |. .|.. .||||| | |..|| .| || .. . ... . . ..| .| . .. ..
qGgrkymeDvvaivleeeesae......elevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktksg
---KDGSTVAIIMAMDNVLYSGNLGDSKSVMYRRSDegdtgGEPPVISVPLTKDHTSAS
|.|..... .. || .. |||. |. . . .|. ... .||||| |
llstaGttasvviirreklyvahvGDsaivlgvkep.....kekklrakeltkdHkPes
|
|||||||||
| subfamily_PPM1G2_pd | Subfamily PPM1G2 | 187-266 | 1.4e-16 | 53.3 | In-house | 159-246 (287) | alignment | ||
Range on Protein: 187-266
Range on HMM: 159-246/287.0
LEERKRIEKSGGFVREGRIMGIMEVSRSIGDGRFKGCG--------LIATPHVSRCELTENDLFVVVACDGLWNVFKMDEVAKFILGV
.|.|||...|||| .|. | . .||..|| || . |.| | .|.|.| |.|.||||.|.|.. .|| ...
esekkriiaagGfvelnrvngnLalsralgDfefkknvkkkpeeqivtavPDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrer
|
|||||||||
| subfamily_PP2D1_pd | Subfamily PP2D1 | 188-316 | 2.8e-14 | 45.7 | In-house | 221-353 (492) | alignment | ||
Range on Protein: 188-316
Range on HMM: 221-353/492.0
EERKRIEKSGGFVR----EGRIMGIMEVSRS---IGDGRFKGcGLIATPHVSRCELTENDLFVVVACDGLWNVFKMDEVAKFILGVVN--DESIQKPGED
.||.|.||.|. | |.. ||... | .||.. | .| |.. .|.|.. |.|.| |||.|.. .||.. . .... .....
kERtRvekagsvvvkseknglvnGildttRGLGnyGdpkLkk.svipePkttsvkldeaaqflvlAsnGlWevlseeevlsLvkqtlaiyksrvraenvp
DrliqgTEVV-SDREYRFEVACNRLAVEAVKRGCTDNVT
| ..| .| |. ...|. . . | . ||
d.....sdvttvgedylgEleakklsaryentgfdkfvt
|
|||||||||
| subfamily_KAPP-like_pd | Subfamily KAPP-like | 188-259 | 1.3e-12 | 40.4 | In-house | 149-224 (266) | alignment | ||
Range on Protein: 188-259
Range on HMM: 149-224/266.0
EERKRIEKSGGFVREG--RIMGIMeVSRSIGDGRFK--GCGLIATPHVS-RCELTENDLFVVVACDGLWNVFKMDEV
||..|| . | . .. || |.. |||..|| | .|||..|.|| | || | |..|| ||||.| . ..
eekqrikddGitlsdnqtrinGla.vsralGdhfikelniGlisepyvsnrilltpfdkflivasdGlwdvisGkda
|
|||||||||
| subfamily_Dicty-PPM-1_pd | Subfamily Dicty-PPM-1 | 188-259 | 1.4e-12 | 40.1 | In-house | 159-234 (276) | alignment | ||
Range on Protein: 188-259
Range on HMM: 159-234/276.0
EERKRIEKSGGFVREG--RIMGIMeVSRSIGDGRFK--GCGLIATPHVS-RCELTENDLFVVVACDGLWNVFKMDEV
||..|| . | . .. || |.. |||..|| | .|||..|.|| | || | |..|| ||||.| . ..
eekqrikddGitlsdnqtrinGla.vsralGdhfikelniGlisepyvsnrilltpfdkflivasdGlwdvisGkda
|
|||||||||
| subfamily_PPM1K_pd | Subfamily PPM1K | 46-145 | 3.8e-11 | 35.6 | In-house | 30-129 (263) | alignment | ||
Range on Protein: 46-145
Range on HMM: 30-129/263.0
SVSYYGVFDGHSGSRASEFAAGNLHRVIVNKFPKEDvsaqSIKRCLVDSFKKTDSDFLS---LAAKATPSWKDGSTVAIIMAMD-NVLYSGNLGDSKSVM
. |..|||||.|| | .|. .|.... . ..||. .. |...|.. | .. . . . . |.| .. . | . | .||||....
ellyvavfdGhaGsaaadfvhdklekilkrllekek....dleivlknafeeldkklkrylefsvaeaellssGttatvsllrdGtelvlaslGdsrail
YRRS
|.
crnG
|
|||||||||
| subfamily_PPM1K_pd | Subfamily PPM1K | 188-266 | 2.1e-10 | 33.2 | In-house | 144-228 (263) | alignment | ||
Range on Protein: 188-266
Range on HMM: 144-228/263.0
EERKRIEKSGGFVR-----EGRIMGIMEVSRSIGDGRFKGCGLIATPHVSRCEL-TENDLFVVVACDGLWNVFKMDEVAKFILGV
||..|| ..||.| . .. | . ..||.|| .| |.||||. . .. ..| |.|. ||. .| . |.....
eekerikaagGsvewnslgkplvngrlamtrslGdldlkryGviatPetkslkvdhaadsflvlitdgisfvvnsqelcdlvrlc
|
|||||||||
| subfamily_PHLPP_pd | Subfamily PHLPP | 186-263 | 5.1e-10 | 31.6 | In-house | 135-212 (246) | alignment | ||
Range on Protein: 186-263
Range on HMM: 135-212/246.0
QLEERKRIEKSGGFVRE-GRIMGIMEVSRSIGDGrFKGCGLIATPHVSRCELTENDLFVVVACDGLWNVFKMDEVAKFI
. .| ||| . ... | ..| |..| .| .| | .. .|||. |||.| ...| . ||.|. .||... .
ekdelkrikeakaiitednkingviestrllGyt.flfPvvlPkphvrevlLteqdellivGnkalWevlsideaveav
|
|||||||||
| subfamily_PDP_pd | Subfamily PDP | 225-277 | 1.3e-09 | 30.7 | In-house | 270-322 (398) | alignment | ||
Range on Protein: 225-277
Range on HMM: 270-322/398.0
LIATPHVSRCELTENDLFVVVACDGLWNVFKMDEVAKFILGVVNDESIQKPGE
|.|.| | .|.||| |.|.| ||||.... .||.. . .... ..| .
ltaePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkkekepvk
|
|||||||||
| subfamily_Choan-PPM1K-like_pd | Subfamily Choan-PPM1K-like | 49-165 | 2e-08 | 27.1 | In-house | 22-130 (292) | alignment | ||
Range on Protein: 49-165
Range on HMM: 22-130/292.0
Y-YGVFDGHS--GSRASEFAAGNLHRVIVNKFPKEdvsaQSIKRCLVDSFKKTDSDFLSLAAKATPSwkDGSTVAIIMAMDN-VLYSGNLGDSKSVMYRR
. |.||| | . ...|. .| ... ... | . |. .. . . | ..| | ...| . |. |. |.|||.....|
flaavldGhGvnGdkvaqlaedtlevelleltrql....qelsealllrildiaakldkltidares..attavvcarvrddralilanvGdsrallgrc
SDEGDTggEPpvisVPLTKDH
| |. .||..||
lggsdy..el....iPlsrdh
|
|||||||||
| subfamily_PPM1G_pd | Subfamily PPM1G | 16-102 | 8.8e-08 | 24.6 | In-house | 27-99 (473) | alignment | ||
Range on Protein: 16-102
Range on HMM: 27-99/473.0
RGEREEMQDSHVIINDMMEQfptlsnspvssVSYYGVFDGHSGSRASEFAAGNLHRVIVNKfpkEDVSAQSIKRCLVDSFKKTDSDF
| |... |.| | |. |. .| ..|.||| |. ... | .| .. .. . . ....| ..| . |.
qGwrvsqEDahncitdlded...........tslfavyDGHGGkevakyvakklpdllkaq...kgykegdvekaleeaflalDekl
|
|||||||||
| subfamily_KAPP-like_pd | Subfamily KAPP-like | 22-143 | 1.7e-07 | 23.6 | In-house | 12-132 (266) | alignment | ||
Range on Protein: 22-143
Range on HMM: 12-132/266.0
MQDSHVIINDMMEQfPTLSNspVSSVSYYGVFDGHSGSRASEFAAGNLHRVIVNKFPK---EDV--SAQSIKRCLVDSFKKTDSDF-----LSLAAKATP
|.| .. | .... ||| .| .. ..|||||.| |.. | . ... .. . .| . .. | ..||. |. . .| .
medvslaiypllke.kklsn..csnialfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafkevdaklkdfeyeGatatlal
SWKDGstvaiimaMDNVLYSGNLGDSKSVMYR
|.|| | ..|.||| . . |
vwsdG........qqrylqvanvGdssaflsr
|
|||||||||
| subfamily_TAB1_pd | Subfamily TAB1 | 49-103 | 2.2e-07 | 23.0 | In-house | 29-83 (333) | alignment | ||
Range on Protein: 49-103
Range on HMM: 29-83/333.0
YYGVFDGHSGSRASEFAAGNLHRVIVNKFPKEDVSAQSIKRCLVDSFKKTDSDFL
|.||||. |..|..|.. .| .... ..... . .|. | |.... ||
lyavFdGydGnkaakfveqrLvaellleqltdelaeaevkevlkrafeeverkfl
|
|||||||||
| subfamily_PPM1H_pd | Subfamily PPM1H | 201-320 | 2.9e-07 | 22.6 | In-house | 273-400 (404) | alignment | ||
Range on Protein: 201-320
Range on HMM: 273-400/404.0
REGRIMGIMEVSRSIGDGRFKGCG--------LIATPHVSRCELTE----NDLFVVVACDGLWNVFKMDEVAKFILGVVNDESIQKPGEDDRLIQgtEVV
. |... . |.| .|| | . | ..|.|. .||. .| ...| ||||.| . .|||. . |... . . . . | |.|
kkaRllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskvepedkkrytavaq..eLv
SDREYRFEVACNRlaVEAVKRGCTDNVTVLIV
... | .. | . .|...|...
aaarGklkdkgWr..lkeekaasvDDisvfvi
|
|||||||||
| subfamily_PPM1H_pd | Subfamily PPM1H | 39-77 | 7.2e-07 | 21.3 | In-house | 54-92 (404) | alignment | ||
Range on Protein: 39-77
Range on HMM: 54-92/404.0
LSNSPVSSVSYYGVFDGHSGSRASEFAAGNLHRVIVNKF
|... .. |.|.||||.|| |. |. .||... .|.
kseeeklplayfglfDGhaGsgaalvaskllhkhlkekl
|
|||||||||
| subfamily_PP2D1_pd | Subfamily PP2D1 | 22-85 | 7.5e-07 | 21.2 | In-house | 17-71 (492) | alignment | ||
Range on Protein: 22-85
Range on HMM: 17-71/492.0
MQDSHVIINDMMEQfptlsnspvSSVSYYGVFDGHSGSRASEFAAGNLHRVIVNKFPKEDVSAQ
|.| ... .. ... ....|..||. |. | | || .||.|.... | | . .
meDkrtlqdyfgnd.........vnscFfgiyDGynGataAeiaakelhevlleelekvdervs
|
|||||||||
| PP2C_SIG_SM00331 | 50-321 | 3.9e-06 | 19.6 | In-house | 33-216 (217) | alignment | |||
Range on Protein: 50-321
Range on HMM: 33-216/217.0
YGVFDGHSGSRASEFAAGNLHRVIVNKFPKEdvsaqsikRCLVDSFKKTDSDFLSLaakatPSWKDGSTVAIIMA---MDNVLYSGNLGDSKSVMYRrsd
. |.||. . |.. |.. |. .. . . .. |.. .|.... . .. |.. . .... .. |. |.||| ...|
lvvaDgmGkGlaAaaassqlrtalrellseg........eelsqalkrlnraiyee.....keekgmfaTlllalydfssgklsyanaGdsrpyllr...
E----GDTGGeppvisvpltkdhtsasvsyifdydffiifcffqleerkrieksggfvREGRIMGIMEVSRsigdgrfkgcgliatPHVSRCELTENDLF
. .. ||...|... .. . .. || . ||.
dgklveilkd................................................vegaplGlepevs...............vdirelelekgdll
VvVACDGLWNV-----FKMDEVAKFILGVVnDESIQKPGEdDRLIQGTEVVSDREYrfevacnrlaveavkrgcTDNVTVLIVD
. . |||... |. ... ... | |.. |. .. ... . | . .... |..||..|.
l.lytDGltearsekgfaeerleeiledlv.dseaqelaq.kiveellelakgsng..................eDdiTvvvvk
|
|||||||||