Gene AquePPM-Un-1 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP206_AA protein Get Run
AqueP206_AA_289-496 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0034914 PP2C-like 290-496 3.4e-24 78.4 In-house 80-291 (295) alignment 
Range on Protein: 290-496
Range on HMM: 80-291/295.0
RHLRKNYLKYEVADCDIKGAIHHTFLKINDKMFDEYSERpicmicanyydilleswspndHSHSTAGMTVSLLFIKGSQVFVANVGDSDIVMAiK-Neky
..|.| .| ..  . ||. |.. .||... .....  .|                     ..... | |.....|.|....||||||| .|.  . .   
ellekllllltlsledieealrkaflaadeellelallr.....................pelagsGtTavvalirgnklyvanvGDSravll.rng...

gqrgeqplKAVKITESHTTRNVKELQQIKSSG-----------------------------------------VTSFSLT-DDIEYFIITTDEFWDVFSE
        ..| .|. |.  |  | . |.|.|                                         ||...|| .| ..... .| .|||.|.
........elvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdfdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsn

IDVIEFVEQKRNGkeiglLKEDYDVCEGLVYEALEKNSTDNISLILVTVD
 .....| .  ..      ..  ...| || .||...|.|||. ..| ..
eeivdivrsllak.....gldleeaaeeLvdlAlargsrDNiTvvvvrln
0049733 PP2C-like 301-496 2.8e-17 56.1 In-house 59-234 (235) alignment 
Range on Protein: 301-496
Range on HMM: 59-234/235.0
VADCDIKGAIHHTFLKINDKMFDEyserpicmicanyydilleswSPNDHSHSTAGMTVSLLFIKGSQVFVANVGDSDIVMAIKNekygqrgeqplKAVK
    |.. |....||..|. ....                     . ....... | |...... |....||||||| ...  ..           |.| 
lllldleealrkaflaaneallel.....................alaspelagmgtTavvalldggklyvanvGDsrayllrdg...........klvq

ITESHTTRNVKELQQIKSSG-----------------------VTSFSLTDDIeYFIITTDEFWDVFSEIDVIEFVEQkrngkeigllKEDYDVCEGLVY
.|| |.  |  | | |.. |                       ||.. |...  ......| .|||.|. ...... .          ..  ...| || 
ltedhspvnelerqriitaggavrvpgrlaltralGdlllkpdvtvlelepgd.flllasDGlwdvlsdeeivdllrs..........ldleeaaerlve

EALEKNSTDNISLILVTVD
.||.....|||....| .|
lalarggrDNiTvvvvrld
subfamily_PPM1D_pd Subfamily PPM1D 341-420 5.8e-17 54.7 In-house 93-168 (309) alignment 
Range on Protein: 341-420
Range on HMM: 93-168/309.0
LLESWSPNDHS-HSTAGMTVSLLFIKGSQVFVANVGDSDIVMAIKNEkygqrGEQPLKAVKITESHTTRNVKELQQIKSSG
 ||.|... .   |||| |.|...|......||.||||.||...|..     .|. |.| ..|..|   ...| ..|...|
kleeWpktksgllstaGttasvviirreklyvahvGDsaivlgvkep.....kekklrakeltkdHkPespeekerieelG
subfamily_PPM1A_pd Subfamily PPM1A 408-495 1.8e-13 43.5 In-house 198-280 (282) alignment 
Range on Protein: 408-495
Range on HMM: 198-280/282.0
RNVKELQQIKSSGVTSFSLTDDIEYFIITTDEFWDVFSEIDVIEFVEQKrngkeIGLLKEDYDVCEGLVYEALEKNSTDNISLILVTV
.. .|.. .... |||.. ... ...... |  ||| |. .|.|.|...     ..  .|   |.. || .||||.|.||.|...|. 
kkaeeqlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkr.....levadeleevakalvdkalekgsrDNlsvlvvlf
PP2Cc_SM00332 298-420 6.7e-13 41.6 In-house 70-164 (274) alignment 
Range on Protein: 298-420
Range on HMM: 70-164/274.0
KYEVADC---DIKGAIHHTFLKINDKMFDEYS-ERPICmicanyydilleswspndhshSTAGMTVSLLFIKGSQVFVANVGDSDIVMAIKNEkygqrge
.....|.   |.. |..  ||...... .|.. ...                       ...| |... ..|. ...||||||| .|.. ...       
lkkkkdeleddveealkkaflstdeeileeeqskelen.....................alsGstavvallkkedlyvanvGDSravlcrngk.......

qplkAVKITESHTTRNVKELQQIKSSG
    || ... |.. . .|.. ||..|
....avqlsvdhkpedederkRikkag
PPM_PTC7 341-422 2.1e-12 40.1 In-house 88-158 (259) alignment 
Range on Protein: 341-422
Range on HMM: 88-158/259.0
LLESWSPNDhSHSTAGMTVSLLFIKGSQVFVANVGDSDIVMAIKNEKYgqrgeqplkaVKITESHTTRNVKELQQIKSSGVT
 |.| . |.  .|| | | ....| ||...||||||| .|...... .          .. ||.|.. | .| ..|...|..
elksseant.epstsGstAvvalitgsklyvAnvGDSravLcrsgnav..........kqltedHkpsnedEreRiegaggs
PP2C Protein phosphatase 2C 347-420 7.6e-12 38.3 Pfam-A 93-155 (255) alignment 
Range on Protein: 347-420
Range on HMM: 93-155/255.0
PNDhSHSTAGMTVSLLFIKGSQVFVANVGDSDIVMAIKNEKYgqrgeqplkaVKITESHTTRNVKELQQIKSSG
 |. ..|. | | .. .|.|....||||||| .|...|.. .          ...|| |.. . .| . |...|
ant.epsksGstavvalirgkklyvAnvGDSravLcrkdnak..........keltedHkpsdedEreRIeeag
PP2C Protein phosphatase 2C 347-420 7.6e-12 38.3 In-house 93-155 (255) alignment 
Range on Protein: 347-420
Range on HMM: 93-155/255.0
PNDhSHSTAGMTVSLLFIKGSQVFVANVGDSDIVMAIKNEKYgqrgeqplkaVKITESHTTRNVKELQQIKSSG
 |. ..|. | | .. .|.|....||||||| .|...|.. .          ...|| |.. . .| . |...|
ant.epsksGstavvalirgkklyvAnvGDSravLcrkdnak..........keltedHkpsdedEreRIeeag
subfamily_PPM1E_pd Subfamily PPM1E 418-495 3.3e-10 32.6 In-house 189-262 (265) alignment 
Range on Protein: 418-495
Range on HMM: 189-262/265.0
SSGVTSFSLTDDIEYFIITTDEFWDVFSEIDVIEFVEQKRNGKEigllKEDYDVCEGLVYEALEKNSTDNISLILVTV
 . |....|... || |...| .|||. | .|.. ||.  . ..    ..  .| . || .| |..|.|||. ..| .
eadvaeveldgseeylilacDGlwDvvneeevvklveefladga....edlsevakllveaakeagssDnitvvvvfl
PP2Cc_SM00332 421-493 1.2e-09 31.0 In-house 204-274 (274) alignment 
Range on Protein: 421-493
Range on HMM: 204-274/274.0
VTSFSLTDDIEYFIITTDEFWDVFSEIDVIEFVEQKRNGKeigLLKEDYDVCEGLVYEALEK-NSTDNISLILV
|.  .||.. | .|. .|  |||.|. .|...|..... .     ..  ...| |. ||... .|.|||. ..|
vkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakg...ktndpqeaaelldeeairrggseDniTvvvv
PP2C Protein phosphatase 2C 421-488 2.8e-09 29.9 Pfam-A 193-255 (255) alignment 
Range on Protein: 421-488
Range on HMM: 193-255/255.0
VTSFSLTDDIEYFIITTDEFWDVFSEIDVIEFVEQKRNGKEigllkEDYDVCEGLVYEALEKNSTDNI
|||..||.. |..|. .|..|||.|. .....|..... |.     .  ...| || ||....|.|||
vtsvklteedefliLasdGlwdvlsdqeavdlvrselskkk.....spmeaaeelvdeaiargsedni
PP2C Protein phosphatase 2C 421-488 2.8e-09 29.9 In-house 193-255 (255) alignment 
Range on Protein: 421-488
Range on HMM: 193-255/255.0
VTSFSLTDDIEYFIITTDEFWDVFSEIDVIEFVEQKRNGKEigllkEDYDVCEGLVYEALEKNSTDNI
|||..||.. |..|. .|..|||.|. .....|..... |.     .  ...| || ||....|.|||
vtsvklteedefliLasdGlwdvlsdqeavdlvrselskkk.....spmeaaeelvdeaiargsedni
PPM_PTC7 421-488 6.4e-09 28.6 In-house 198-259 (259) alignment 
Range on Protein: 421-488
Range on HMM: 198-259/259.0
VTSFSLTDDIEYFIITTDEFWDVFSEIDVIEFVEQKRNGKeigllkEDYDVCEGLVYEALEKNSTDNI
..|  .... |..|. .|..|||.|. .....| . .. |      .  ...| || ||....|.|||
isstkideedefliLasdGlwdvvsdqeavdlvrselskk......dpmeaaeklvdeaiargsedni
subfamily_PDP_pd Subfamily PDP 287-418 1.6e-08 27.0 In-house 95-209 (398) alignment 
Range on Protein: 287-418
Range on HMM: 95-209/398.0
LVQRHLRK---NYLKYEVAdcDIKGAIHHTFLKINDKMFDEYSERPicmicanyydilLESWSPNDHSHSTAGMTVSLLFIKGSQVFVANVGDSDIVMAI
| . .|.|   . |. ||   ..| |....|||. . . .|  ..              |. . .    ...| .  | .|.| ...|||.||.  |.. 
lslselskylqelleaeve..kvkealkkaFlklDkdistealkkl............kekslreallvalsGacallaliegtelhvAntGDcravlgv

KNEKyGQrgeqpLKAVKITESHTTRNVKELQQIKS
..|. |.      .|||... .|..| .|.. ||.
qeee.gs.....weavkLskdqtadneeEveRikk
PPM_PTC7_SpoIIE 295-473 6e-08 25.8 In-house 31-215 (230) alignment 
Range on Protein: 295-473
Range on HMM: 31-215/230.0
NYLKYEVADCDIKGAIHHTFLKINDKMFD---------------------------EyserpicmicanyydilleswspndhsHSTAGMTVSLLFIKGS
..|   |.|.| .|   . . .   ....                           |                           .|. | |.... | .|
grlalvvgdvdGhGgraalamgllrtalrelafaglekpeeilrrlnlalaadlede...........................psssgaTavvalidps

Q--VFVANVGDSDIVMAIK--NEKYGQRGEQPL-----KAVKITESHTTRNVKELQQIKSSGVTSFS---LTDDI----EYFIITTDEFWDVFSEIDVIE
.  . |||.||| ...  .   |..   .  ..        .  .   ..  ..|    . ||.. .    ..      |. |. .| .||| |  ....
tgklyvanaGdsppllvrddggererivagglpslGilpgrvfgvlavslapGdllllytDGvveaepdtsdgelfgkdeflilasdglwdvlspqelvd

FVEQKRNGKeigllkedydVCE
.| . .. .          ..|
lvrdelekp..........aae
subfamily_PPM1G2_pd Subfamily PPM1G2 420-495 5.2e-07 21.9 In-house 210-286 (287) alignment 
Range on Protein: 420-495
Range on HMM: 210-286/287.0
GVTSFSLTDDIEYFIITTDEFWDVFSEIDVIEFVEQKRNGKeigllKEDYDVCEGLVYEALEKNST------DNISLILVTV
 |.  .|..| |. ..  |  |||... .|...| ..   .     ..  ...| |. ..| ..|       ||.....|..
DvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsg.....akldeiieelldkclapdssntgvGcDnmtvvivvl
subfamily_ILKAP_pd Subfamily ILKAP 424-495 5.7e-07 22.0 In-house 210-292 (293) alignment 
Range on Protein: 424-495
Range on HMM: 210-292/293.0
FSLTDDIEYFIITTDEFWDVFSEIDVIEFVEQKRNGK--------EIGLLKEDY---DVCEGLVYEALEKNSTDNISLILVTV
  ||..  . ... | .|.|||  .|..|. .  . .        | .. ||..    .|. |  ||....|.||.. .|| .
ceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrkikeeekkskeevrfevacnrlaseavkrgssdnvtvllvki
Subfamily Dicty-PPM1L-like 431-494 1.1e-06 20.7 In-house 237-302 (305) alignment 
Range on Protein: 431-494
Range on HMM: 237-302/305.0
EYFIITTDEFWDVFSEIDVIEFVEQKRNGKEIGL-LKEDY-DVCEGLVYEALEKNSTDNISLILVT
......||  |.|.|  ||.|.|... . | ..  .. |. .. .  | ||....| ||| |... 
qflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneisrviveeavkrgsgDnitlviik
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 313-421 1.6e-06 20.6 In-house 57-151 (255) alignment 
Range on Protein: 313-421
Range on HMM: 57-151/255.0
TFLKINDKMFDEYSERPICMICANYYDILLESwspNDHShSTAGMTVSLLFIKGSQVFVANVGDSDIVMAiknekygqrgEQPLKAVKITESHTTRNVKE
.. ||  ...| ..  |. ..   | .| .     ....    | |   ..| . .|..|||||| .|..          ..   |....  |   . .|
elykilaelldlnnanPvkslkkaykeistqi...serp.kfiGttaasvliiedkvyianvGdsrvvlc..........qkdgtakrlsldhkPseese

LQQIKSSGV
 ..|.  | 
ekriselGG
PPM_PTC7_motif 434-488 1.8e-06 21.3 In-house 1-51 (51) alignment 
Range on Protein: 434-488
Range on HMM: 1-51/51.0
IITTDEFWDVFSEIDVIEFVEQKRN-GKEigllkEDYDVCEGLVYEALEKNSTDNI
|. .|..|||.|. .....| . ..  ..     .   ..| || |||...|.|||
iLAsDGLWDvlsdqeavdlvrdqlskkgl.....spqeaAeklvdealargseDni
subfamily_ILKAP_pd Subfamily ILKAP 356-421 7.8e-06 18.2 In-house 114-174 (293) alignment 
Range on Protein: 356-421
Range on HMM: 114-174/293.0
GMTVSLLFIKGSQVFVANVGDSDIVMAIKNEKYGQrgeqpLKAVKITESHTTRNVKELQQIKSSGV
| |. ....    ..|||.|||  |.. |.|.  .     ...|..|  ||. . .| ..|. .| 
GstatvvlvldnvlyvanlGdskavlvrkkeegdk.....iasvvLtkdhtpvkyeerkriqkaGg