Gene AquePPM-Un-1 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP206_AA protein Get Run
AqueP206_AA_289-496 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0034914 PP2C-like 290-496 3.4e-24 78.4 In-house 80-291 (295) alignment
Range on Protein: 290-496
Range on HMM: 80-291/295.0
RHLRKNYLKYEVADCDIKGAIHHTFLKINDKMFDEYSERpicmicanyydilleswspndHSHSTAGMTVSLLFIKGSQVFVANVGDSDIVMAiK-Neky
..|.| .| ..  . ||. |.. .||... .....  .|                     ..... | |.....|.|....||||||| .|.  . .   
ellekllllltlsledieealrkaflaadeellelallr.....................pelagsGtTavvalirgnklyvanvGDSravll.rng...

gqrgeqplKAVKITESHTTRNVKELQQIKSSG-----------------------------------------VTSFSLT-DDIEYFIITTDEFWDVFSE
        ..| .|. |.  |  | . |.|.|                                         ||...|| .| ..... .| .|||.|.
........elvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdfdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsn

IDVIEFVEQKRNGkeiglLKEDYDVCEGLVYEALEKNSTDNISLILVTVD
 .....| .  ..      ..  ...| || .||...|.|||. ..| ..
eeivdivrsllak.....gldleeaaeeLvdlAlargsrDNiTvvvvrln

0049733 PP2C-like 301-496 2.8e-17 56.1 In-house 59-234 (235) alignment
Range on Protein: 301-496
Range on HMM: 59-234/235.0
VADCDIKGAIHHTFLKINDKMFDEyserpicmicanyydilleswSPNDHSHSTAGMTVSLLFIKGSQVFVANVGDSDIVMAIKNekygqrgeqplKAVK
    |.. |....||..|. ....                     . ....... | |...... |....||||||| ...  ..           |.| 
lllldleealrkaflaaneallel.....................alaspelagmgtTavvalldggklyvanvGDsrayllrdg...........klvq

ITESHTTRNVKELQQIKSSG-----------------------VTSFSLTDDIeYFIITTDEFWDVFSEIDVIEFVEQkrngkeigllKEDYDVCEGLVY
.|| |.  |  | | |.. |                       ||.. |...  ......| .|||.|. ...... .          ..  ...| || 
ltedhspvnelerqriitaggavrvpgrlaltralGdlllkpdvtvlelepgd.flllasDGlwdvlsdeeivdllrs..........ldleeaaerlve

EALEKNSTDNISLILVTVD
.||.....|||....| .|
lalarggrDNiTvvvvrld

subfamily_PPM1D_pd Subfamily PPM1D 341-420 5.8e-17 54.7 In-house 93-168 (309) alignment
Range on Protein: 341-420
Range on HMM: 93-168/309.0
LLESWSPNDHS-HSTAGMTVSLLFIKGSQVFVANVGDSDIVMAIKNEkygqrGEQPLKAVKITESHTTRNVKELQQIKSSG
 ||.|... .   |||| |.|...|......||.||||.||...|..     .|. |.| ..|..|   ...| ..|...|
kleeWpktksgllstaGttasvviirreklyvahvGDsaivlgvkep.....kekklrakeltkdHkPespeekerieelG

subfamily_PPM1A_pd Subfamily PPM1A 408-495 1.8e-13 43.5 In-house 198-280 (282) alignment
Range on Protein: 408-495
Range on HMM: 198-280/282.0
RNVKELQQIKSSGVTSFSLTDDIEYFIITTDEFWDVFSEIDVIEFVEQKrngkeIGLLKEDYDVCEGLVYEALEKNSTDNISLILVTV
.. .|.. .... |||.. ... ...... |  ||| |. .|.|.|...     ..  .|   |.. || .||||.|.||.|...|. 
kkaeeqlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkr.....levadeleevakalvdkalekgsrDNlsvlvvlf

PP2Cc_SM00332 298-420 6.7e-13 41.6 In-house 70-164 (274) alignment
Range on Protein: 298-420
Range on HMM: 70-164/274.0
KYEVADC---DIKGAIHHTFLKINDKMFDEYS-ERPICmicanyydilleswspndhshSTAGMTVSLLFIKGSQVFVANVGDSDIVMAIKNEkygqrge
.....|.   |.. |..  ||...... .|.. ...                       ...| |... ..|. ...||||||| .|.. ...       
lkkkkdeleddveealkkaflstdeeileeeqskelen.....................alsGstavvallkkedlyvanvGDSravlcrngk.......

qplkAVKITESHTTRNVKELQQIKSSG
    || ... |.. . .|.. ||..|
....avqlsvdhkpedederkRikkag

PPM_PTC7 341-422 2.1e-12 40.1 In-house 88-158 (259) alignment
Range on Protein: 341-422
Range on HMM: 88-158/259.0
LLESWSPNDhSHSTAGMTVSLLFIKGSQVFVANVGDSDIVMAIKNEKYgqrgeqplkaVKITESHTTRNVKELQQIKSSGVT
 |.| . |.  .|| | | ....| ||...||||||| .|...... .          .. ||.|.. | .| ..|...|..
elksseant.epstsGstAvvalitgsklyvAnvGDSravLcrsgnav..........kqltedHkpsnedEreRiegaggs

PP2C Protein phosphatase 2C 347-420 7.6e-12 38.3 Pfam-A 93-155 (255) alignment
Range on Protein: 347-420
Range on HMM: 93-155/255.0
PNDhSHSTAGMTVSLLFIKGSQVFVANVGDSDIVMAIKNEKYgqrgeqplkaVKITESHTTRNVKELQQIKSSG
 |. ..|. | | .. .|.|....||||||| .|...|.. .          ...|| |.. . .| . |...|
ant.epsksGstavvalirgkklyvAnvGDSravLcrkdnak..........keltedHkpsdedEreRIeeag

PP2C Protein phosphatase 2C 347-420 7.6e-12 38.3 In-house 93-155 (255) alignment
Range on Protein: 347-420
Range on HMM: 93-155/255.0
PNDhSHSTAGMTVSLLFIKGSQVFVANVGDSDIVMAIKNEKYgqrgeqplkaVKITESHTTRNVKELQQIKSSG
 |. ..|. | | .. .|.|....||||||| .|...|.. .          ...|| |.. . .| . |...|
ant.epsksGstavvalirgkklyvAnvGDSravLcrkdnak..........keltedHkpsdedEreRIeeag

subfamily_PPM1E_pd Subfamily PPM1E 418-495 3.3e-10 32.6 In-house 189-262 (265) alignment
Range on Protein: 418-495
Range on HMM: 189-262/265.0
SSGVTSFSLTDDIEYFIITTDEFWDVFSEIDVIEFVEQKRNGKEigllKEDYDVCEGLVYEALEKNSTDNISLILVTV
 . |....|... || |...| .|||. | .|.. ||.  . ..    ..  .| . || .| |..|.|||. ..| .
eadvaeveldgseeylilacDGlwDvvneeevvklveefladga....edlsevakllveaakeagssDnitvvvvfl

PP2Cc_SM00332 421-493 1.2e-09 31.0 In-house 204-274 (274) alignment
Range on Protein: 421-493
Range on HMM: 204-274/274.0
VTSFSLTDDIEYFIITTDEFWDVFSEIDVIEFVEQKRNGKeigLLKEDYDVCEGLVYEALEK-NSTDNISLILV
|.  .||.. | .|. .|  |||.|. .|...|..... .     ..  ...| |. ||... .|.|||. ..|
vkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakg...ktndpqeaaelldeeairrggseDniTvvvv

PP2C Protein phosphatase 2C 421-488 2.8e-09 29.9 Pfam-A 193-255 (255) alignment
Range on Protein: 421-488
Range on HMM: 193-255/255.0
VTSFSLTDDIEYFIITTDEFWDVFSEIDVIEFVEQKRNGKEigllkEDYDVCEGLVYEALEKNSTDNI
|||..||.. |..|. .|..|||.|. .....|..... |.     .  ...| || ||....|.|||
vtsvklteedefliLasdGlwdvlsdqeavdlvrselskkk.....spmeaaeelvdeaiargsedni

PP2C Protein phosphatase 2C 421-488 2.8e-09 29.9 In-house 193-255 (255) alignment
Range on Protein: 421-488
Range on HMM: 193-255/255.0
VTSFSLTDDIEYFIITTDEFWDVFSEIDVIEFVEQKRNGKEigllkEDYDVCEGLVYEALEKNSTDNI
|||..||.. |..|. .|..|||.|. .....|..... |.     .  ...| || ||....|.|||
vtsvklteedefliLasdGlwdvlsdqeavdlvrselskkk.....spmeaaeelvdeaiargsedni

PPM_PTC7 421-488 6.4e-09 28.6 In-house 198-259 (259) alignment
Range on Protein: 421-488
Range on HMM: 198-259/259.0
VTSFSLTDDIEYFIITTDEFWDVFSEIDVIEFVEQKRNGKeigllkEDYDVCEGLVYEALEKNSTDNI
..|  .... |..|. .|..|||.|. .....| . .. |      .  ...| || ||....|.|||
isstkideedefliLasdGlwdvvsdqeavdlvrselskk......dpmeaaeklvdeaiargsedni

subfamily_PDP_pd Subfamily PDP 287-418 1.6e-08 27.0 In-house 95-209 (398) alignment
Range on Protein: 287-418
Range on HMM: 95-209/398.0
LVQRHLRK---NYLKYEVAdcDIKGAIHHTFLKINDKMFDEYSERPicmicanyydilLESWSPNDHSHSTAGMTVSLLFIKGSQVFVANVGDSDIVMAI
| . .|.|   . |. ||   ..| |....|||. . . .|  ..              |. . .    ...| .  | .|.| ...|||.||.  |.. 
lslselskylqelleaeve..kvkealkkaFlklDkdistealkkl............kekslreallvalsGacallaliegtelhvAntGDcravlgv

KNEKyGQrgeqpLKAVKITESHTTRNVKELQQIKS
..|. |.      .|||... .|..| .|.. ||.
qeee.gs.....weavkLskdqtadneeEveRikk

PPM_PTC7_SpoIIE 295-473 6e-08 25.8 In-house 31-215 (230) alignment
Range on Protein: 295-473
Range on HMM: 31-215/230.0
NYLKYEVADCDIKGAIHHTFLKINDKMFD---------------------------EyserpicmicanyydilleswspndhsHSTAGMTVSLLFIKGS
..|   |.|.| .|   . . .   ....                           |                           .|. | |.... | .|
grlalvvgdvdGhGgraalamgllrtalrelafaglekpeeilrrlnlalaadlede...........................psssgaTavvalidps

Q--VFVANVGDSDIVMAIK--NEKYGQRGEQPL-----KAVKITESHTTRNVKELQQIKSSGVTSFS---LTDDI----EYFIITTDEFWDVFSEIDVIE
.  . |||.||| ...  .   |..   .  ..        .  .   ..  ..|    . ||.. .    ..      |. |. .| .||| |  ....
tgklyvanaGdsppllvrddggererivagglpslGilpgrvfgvlavslapGdllllytDGvveaepdtsdgelfgkdeflilasdglwdvlspqelvd

FVEQKRNGKeigllkedydVCE
.| . .. .          ..|
lvrdelekp..........aae

subfamily_PPM1G2_pd Subfamily PPM1G2 420-495 5.2e-07 21.9 In-house 210-286 (287) alignment
Range on Protein: 420-495
Range on HMM: 210-286/287.0
GVTSFSLTDDIEYFIITTDEFWDVFSEIDVIEFVEQKRNGKeigllKEDYDVCEGLVYEALEKNST------DNISLILVTV
 |.  .|..| |. ..  |  |||... .|...| ..   .     ..  ...| |. ..| ..|       ||.....|..
DvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsg.....akldeiieelldkclapdssntgvGcDnmtvvivvl

subfamily_ILKAP_pd Subfamily ILKAP 424-495 5.7e-07 22.0 In-house 210-292 (293) alignment
Range on Protein: 424-495
Range on HMM: 210-292/293.0
FSLTDDIEYFIITTDEFWDVFSEIDVIEFVEQKRNGK--------EIGLLKEDY---DVCEGLVYEALEKNSTDNISLILVTV
  ||..  . ... | .|.|||  .|..|. .  . .        | .. ||..    .|. |  ||....|.||.. .|| .
ceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrkikeeekkskeevrfevacnrlaseavkrgssdnvtvllvki

Subfamily Dicty-PPM1L-like 431-494 1.1e-06 20.7 In-house 237-302 (305) alignment
Range on Protein: 431-494
Range on HMM: 237-302/305.0
EYFIITTDEFWDVFSEIDVIEFVEQKRNGKEIGL-LKEDY-DVCEGLVYEALEKNSTDNISLILVT
......||  |.|.|  ||.|.|... . | ..  .. |. .. .  | ||....| ||| |... 
qflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneisrviveeavkrgsgDnitlviik

subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 313-421 1.6e-06 20.6 In-house 57-151 (255) alignment
Range on Protein: 313-421
Range on HMM: 57-151/255.0
TFLKINDKMFDEYSERPICMICANYYDILLESwspNDHShSTAGMTVSLLFIKGSQVFVANVGDSDIVMAiknekygqrgEQPLKAVKITESHTTRNVKE
.. ||  ...| ..  |. ..   | .| .     ....    | |   ..| . .|..|||||| .|..          ..   |....  |   . .|
elykilaelldlnnanPvkslkkaykeistqi...serp.kfiGttaasvliiedkvyianvGdsrvvlc..........qkdgtakrlsldhkPseese

LQQIKSSGV
 ..|.  | 
ekriselGG

PPM_PTC7_motif 434-488 1.8e-06 21.3 In-house 1-51 (51) alignment
Range on Protein: 434-488
Range on HMM: 1-51/51.0
IITTDEFWDVFSEIDVIEFVEQKRN-GKEigllkEDYDVCEGLVYEALEKNSTDNI
|. .|..|||.|. .....| . ..  ..     .   ..| || |||...|.|||
iLAsDGLWDvlsdqeavdlvrdqlskkgl.....spqeaAeklvdealargseDni

subfamily_ILKAP_pd Subfamily ILKAP 356-421 7.8e-06 18.2 In-house 114-174 (293) alignment
Range on Protein: 356-421
Range on HMM: 114-174/293.0
GMTVSLLFIKGSQVFVANVGDSDIVMAIKNEKYGQrgeqpLKAVKITESHTTRNVKELQQIKSSGV
| |. ....    ..|||.|||  |.. |.|.  .     ...|..|  ||. . .| ..|. .| 
GstatvvlvldnvlyvanlGdskavlvrkkeegdk.....iasvvLtkdhtpvkyeerkriqkaGg