Gene PPM1A in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1A
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP207_AA protein Get Run
AqueP207_AA_3-294 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1A_pd Subfamily PPM1A 12-293 3.7e-119 390.3 In-house 2-282 (282) alignment 
Range on Protein: 12-293
Range on HMM: 2-282/282.0
KVTSSGEGYGIRYAVSAMQGWRMEMEDSHICDTDF--IKNWSFFGVFDGHAGPKVSQYCSDHILRIMLDdlKASLDECKSTEEPKERIKQAIYDGFLKLD
| .|..|| |.||.||.|||||.||||.|.. ...  .|.|||| ||||||| .|..|...|.|. .|.  . .| |.......|...|.|. .|||.||
kpksqaegnglrygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenile..eeelkeaaleasekdevkealrqgfLald

SKIREDPTWANGEDHSGTTAITVMISPTHIYWANCGDSRGFLCSDGKVKFATEDHKPYLAREKERIEKAGGSVIMQRVNGSLAVSRALGDFDYKRNNSIP
..|||. |.....|.||.||.||..|..|...||.||||..||..||..|.||||||. ..||.|||.|||||...||||.|||||||||..||.... .
eairelstdlktadksGsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDyeykeeeekk

AKEQLVSPEPEIDILPRDSENDeFLLLACDGIYDVMSNEEVMSYVRRQLELTANLEKICNDLIDLCLNKNSRDNMSVVLVVFPN
|.|||||.|||. .. |..|.| ||.||||||.||.|.|||...||..|| . .||.....|.| .|.|.||||.||..|.|..
aeeqlvsaepevtsierseedd.flvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsrDNlsvlvvlfak
0034914 PP2C-like 4-294 1.4e-89 292.6 In-house 3-293 (295) alignment 
Range on Protein: 4-294
Range on HMM: 3-293/295.0
FLEKPKTDKVTSSGEGYGIRYAVSAMQGWRMEMEDSHICDTDF---IKNWSFFGVFDGHAGPKVSQYCSDHILRIMLDDLKASldeCKSTEEPKERIKQA
.|..|.......| . . .|..|. .||.|...||.... ...    .....||||||| | ......|.......|. |.     . ..... | |..|
llslpllellllsslllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekl...lllltlsledieea

IYDGFLKLDSKIREDPTWANGEDHSGTTAITVMISPTHIYWANCGDSRGFLCSDGKVKFATEDHKPYLAREKERIEKAGGSVIMQRVNGSLAVSRALGDF
....||..| ...|   . .  ..|||||....| ....|.||.|||| .|...|.... |.||||.   |.|||..||| |.. ||||.|||.||||||
lrkaflaadeellelallrpelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdf

DYKRNNSIPAKEQLVSPEPEIDILPRDSENDEFLLLACDGIYDVMSNEEVMSYVRRQLELTANLEKICNDLIDLCLNKNSRDNMSVVLVVFPNA
|.|...| ...|.|||.||....|... |.|.|||||.||..||.||||....||. |. . .||.... |.||.|...||||..||.| ... 
dlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTvvvvrlngl
subfamily_PPM1G2_pd Subfamily PPM1G2 5-291 2.3e-87 285.6 In-house 2-286 (287) alignment 
Range on Protein: 5-291
Range on HMM: 2-286/287.0
LEKPKTDKVTSSGEGYGIRYAVSAMQGWRMEMEDSHICDTDFIK-----NWSFFGVFDGHAGPKVSQYCSDHILRIMLDdlkasldecKSTEEpKERIKQ
|..| ..| ..|..   .. . |||||.|..|||.|| ......     . ..|.||||| | ||..|.. .. ...           |.. . .. ..|
lsepvvakesascanaltkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiak.........kksfk.egaleq

AIYDGFLKLDSKIREDPTWANgeDHSGTTAITVMISPTHIYWANCGDSRGFLCSDGKVKFATEDHKPYLAREKERIEKAGGSVIMQRVNGSLAVSRALGD
.. |.||..|.....| . ..  ...|.||..|.|. ...| ||.||||  |.|.|.||  . ||||  . ||.||..||| | ..||||.||.||||||
ilkdafletDeellkdeklkd..esaGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfvelnrvngnLalsralgD

FDYKRNNSIPAKEQLVSPEPEIDILPRDsENDEFLLLACDGIYDVMSNEEVMSYVRRQLELTANLEKICNDLIDLCLNKNSR------DNMSVVLVVF
| .|.|......||.|  .|.. .  .| |.||||.||||||.||..|.||. .|| .|   |.|..|...|.| ||...|.      |||.||.||.
fefkknvkkkpeeqivtavPDvlvkkld.eddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvvivvl
PP2Cc_SM00332 15-289 2.1e-82 269.6 In-house 3-274 (274) alignment 
Range on Protein: 15-289
Range on HMM: 3-274/274.0
SSGEGYGIRYAVSAMQGWRMEMEDSHICDTDFI--KNWSFFGVFDGHAGPKVSQYCSDHILRIMLDDLKASLDECksteepKERIKQAIYDGFLKLDSKI
.||.. |..|..|.||||| .||| |.. .|.   ..|.||||||||.|..|....|... ... . ||  .||       .. ...|....||..|..|
esgsnlglsygkssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdel......eddveealkkaflstdeei

REDPTWANGE-DHSGTTAITVMISPTHIYWANCGDSRGFLCSDGKVKFATEDHKPYLAREKERIEKAGGSVIMQRVNGSLAVSRALGDFDYKRNNsiPAK
.|.    . |   ||.||......  ..| ||.|||| .||..||..  ..||||  ..|..||.||||.|. .||||.||||||.||...|.|.  . |
leeeqskelenalsGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdhflkknk..klk

EQLVSPEPEIDILPRdSENDEFLLLACDGIYDVMSNEEVMSYVRRQL--ELTANLEKICNDLIDLCLNK-NSRDNMSVVLV
|. ...||.. ..    ..||||.||.||..||.||.|| ..||..|  . | . ......|....... .|.||..||.|
epyitaepdvkvvtl.tsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv
PP2C Protein phosphatase 2C 23-284 1.8e-81 266.4 Pfam-A 2-255 (255) alignment 
Range on Protein: 23-284
Range on HMM: 2-255/255.0
RYAVSAMQGWRMEMEDSHICDTDFI-----KNWSFFGVFDGHAGPKVSQYCSDHILriMLDDLKASLDECKsteepkeRIKQAIYDGFLK-LDSKIREDP
.. .|..||.|..|||.||.  ..      ....||.|||||.| ....|.. |.    . ... |..|..         ..|....||. .|.... . 
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehle..eilkeqksflele.......kvekalrksfladtdeelkssk

TWAnGEDHSGTTAITVMISPTHIYWANCGDSRGFLCSDGKVK-FATEDHKPYLAREKERIEKAGGSVI-MQRVNGSLAVSRALGDFDYKRNNsipakEQL
. .  ...||.||....|.....| ||.||||  ||.... | . ||||||.  .|.||||.|||||. ..|||||||||||||||..|...     |||
ant.epsksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eql

VSPEPEIDILPRDSEnDEFLLLACDGIYDVMSNEEVMSYVRRQLELTANLEKICNDLIDLCLNKNSRDNM
||.||..   ....| ||||.||.||..||.|..|... ||..|. . ........|.| .....|.||.
vsaePdvtsvkltee.defliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PP2C Protein phosphatase 2C 23-284 1.8e-81 266.4 In-house 2-255 (255) alignment 
Range on Protein: 23-284
Range on HMM: 2-255/255.0
RYAVSAMQGWRMEMEDSHICDTDFI-----KNWSFFGVFDGHAGPKVSQYCSDHILriMLDDLKASLDECKsteepkeRIKQAIYDGFLK-LDSKIREDP
.. .|..||.|..|||.||.  ..      ....||.|||||.| ....|.. |.    . ... |..|..         ..|....||. .|.... . 
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehle..eilkeqksflele.......kvekalrksfladtdeelkssk

TWAnGEDHSGTTAITVMISPTHIYWANCGDSRGFLCSDGKVK-FATEDHKPYLAREKERIEKAGGSVI-MQRVNGSLAVSRALGDFDYKRNNsipakEQL
. .  ...||.||....|.....| ||.||||  ||.... | . ||||||.  .|.||||.|||||. ..|||||||||||||||..|...     |||
ant.epsksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eql

VSPEPEIDILPRDSEnDEFLLLACDGIYDVMSNEEVMSYVRRQLELTANLEKICNDLIDLCLNKNSRDNM
||.||..   ....| ||||.||.||..||.|..|... ||..|. . ........|.| .....|.||.
vsaePdvtsvkltee.defliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PPM_PTC7 23-284 2.7e-80 262.5 In-house 2-259 (259) alignment 
Range on Protein: 23-284
Range on HMM: 2-259/259.0
RYAVSAMQGWRMEMEDSHICDTDFI-----KNWSFFGVFDGHAGPKVSQYCSDHILriMLDDLKASLDECKsteepkeRIKQAIYDGFLK--LDSKIRED
.. .||.||.|..|||.||.  ..      ....||.|||||.| ....|.. |.      ... |..|..         ..|....||.  .|.... .
dggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehle..eilkerksfeele.......klekalrksflaldtdeelkss

PTWAnGEDHSGTTAITVMISPTHIYWANCGDSRGFLCSDGKVK-FATEDHKPYLAREKERIEKAGGSVI---MQRVNGSLAVSRALGDFDYKRNNSipaK
 . . ....||.||....|.....| ||.||||  ||..|... . ||||||.. .|.||||.|||||.   ..||||.||||||.|||..|.. .   .
eant.epstsGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpket...e

EQLVSPEPEIDILPRDSEnDEFLLLACDGIYDVMSNEEVMSYVRRQLELTaNLEKICNDLIDLCLNKNSRDNM
|||||.||.|   ..|.| ||||.||.||..||.|..|. . ||..|. .  .......|.| .....|.||.
eqlvsaePdisstkidee.defliLasdGlwdvvsdqeavdlvrselskk.dpmeaaeklvdeaiargsedni
0049733 PP2C-like 22-291 5.8e-62 201.9 In-house 3-233 (235) alignment 
Range on Protein: 22-291
Range on HMM: 3-233/235.0
IRYAVSAMQGW-RMEMEDSHICdtdfikNWSFFGVFDGHAGPKVSQYCSDHILRIMLDDLKAsldecksteEPKERIKQAIYDGFLKLDSKIREDPTWAN
...... ..|. | ..||....      ....|.|.||| |  .....|.......|. |..          . . ...|... ||.... ..|  .  .
lsvgaasdigrvrkvneDavlv......glllfavaDGhgghaagevasellvetllellle.........lllldleealrkaflaaneallelalasp

GEDHSGTTAITVMISPTHIYWANCGDSRGFLCSDGKVKFATEDHKPYLAREKERIEKAGGSVimqRVNGSLAVSRALGDFDYKrnnsipakeqlvspepe
. ...||||..... . ..|.||.|||| .|..|||. . ||||.|.   |..||..||| |   ||.|.||..|||||...|                 
elagmgtTavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav...rvpgrlaltralGdlllk.................

IDILPRDSENDEFLLLACDGIYDVMSNEEVMSYVRRqleltANLEKICNDLIDLCLNKNSRDNMSVVLVVF
.|.   . |...|||||.||..||.|.||.....|.      .||.... |..|.|....|||..||.| .
pdvtvlelepgdflllasDGlwdvlsdeeivdllrs.....ldleeaaerlvelalarggrDNiTvvvvrl
subfamily_PPM1E_pd Subfamily PPM1E 24-291 6.5e-52 169.3 In-house 6-262 (265) alignment 
Range on Protein: 24-291
Range on HMM: 6-262/265.0
YAVSAMQGWRMEMEDSHICDTDF--------IKNWSFFGVFDGHAGPKVSQYCSDHILRIMLDDLKASLDECksteepkerikQAIYDGFLKLDSKIRED
  . |... |  ||| |..  |.         |. .||.|||||.| . ..| . |. . . .. |.  |             .|. ..| ..|... . 
vsiaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa...........ealkeafkltDerflqk

PtwANGEDHSGTTAITVMISPTHIYWANCGDSRGFLCSDGKVKFATEDHKPYLAREKERIEKAGGSVIM---QRVNGSLAVSRALGDFDYKrnnsipake
   .. . .||.||..|.|.  ..| |  |||...|...|..   .. |||   .||.|||.||| |..    ||||.|.||||.|| ..|         
a..ereklksGstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklk.........

QLVSPEPEIDILPRDSEnDEFLLLACDGIYDVMSNEEVMSYVRRQLELTA-NLEKICNDLIDLCLNKNSRDNMSVVLVVF
. || |...  .. |.. .|.|.|||||..||. .|||.. |.  |. .| .|... . |..   ...|.||..||.|..
pyvsgeadvaeveldgs.eeylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvvfl
subfamily_PPM1G_pd Subfamily PPM1G 121-291 2e-50 165.2 In-house 293-470 (473) alignment 
Range on Protein: 121-291
Range on HMM: 293-470/473.0
GEDhSGTTAITVMISPTHIYWANCGDSRGFLCSDGKVKFATEDHKPYLAREKERIEKAGGSVIM-QRVNGSLAVSRALGDFDYKRNNSIPAKEQLVSPEP
||| |||||. ...   ... || ||||  |...||     .||||    |.|||||||| | .  |||| | .||||||. ||.|...|.|||..|  |
Ged.sGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplkeqmisAlP

EIDILPRdSENDEFLLLACDGIYDVMSNEEVMSYVRRQLELTA--NLEKICNDLIDLCLNKNSR------DNMSVVLVVF
.| .|    |.|||| ||||||..||. .||. .|| .|. .    |..|...|.| || ..        |||.|..|..
Dikvltl.teedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtviivll
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 24-292 1.8e-48 158.1 In-house 8-254 (255) alignment 
Range on Protein: 24-292
Range on HMM: 8-254/255.0
YAVSAMQGWRMEMEDSHICDTDFIKN--WSFFGVFDGHAGPKVSQYCSDHILRIMLDDLKAsldecKSTeEPKERIKQAiydgFLKLDSKIREDPtwang
 . | | | |  |||. .    | ..    .. .||||.| . ....|... .|. . |..     ... .|.. .|.|    . ... .| | |     
vgfsdmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelykilaelldl.....nna.nPvkslkka....ykeistqiserp.....

eDHSGTTAITVMISPTHIYWANCGDSRGFLC-SDGKVKFATEDHKPYLAREKERIEKAGGSVIMQ----RVNGSLAVSRALGDFdYKrnnsipakEQLVS
  . ||||..|.|   ..| || ||||  ||  ||  |  . ||||   .|..||...|| |. .    |||| |||||||||  .         |  | 
.kfiGttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGds.fl........ePfvv

PEPEIDILPRDSENDEFLLLACDGIYDVMSNEEVMSYVRRqlelTANLEKICNDLIDLCLNKNSRDNMSVVLVVFP
|.|...   . |..|.||.||||||.|..|.|| .. |       .. || .. | ||  .. | ||.||... ..
pdPdlsqsleiskkdkflilacdGiwdlisdeeaveivag....isdpekaaeklrdlayssGstdnisvivikls
PPM_PTC7_SpoIIE 23-274 7.3e-45 146.5 In-house 2-220 (230) alignment 
Range on Protein: 23-274
Range on HMM: 2-220/230.0
RYAVSAMQGWRMEMEDSHICDTDFI-----KNWSFFGVFDGHAGPKvsQYCSDHILRIMLDDLKASLDecksteepkeRIKQAIYDGFLKLDSKIREDpt
.. .||.||.| .|||.||.  ..        . ..|..||| |.   .... ..  ..    .|.|.            ........|.|. .....  
dggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrelafagle..........kpeeilrrlnlalaadlede..

wangEDHSGTTAITVMISPTH--IYWANCGDSRGFLCSD-GKvkfatedhkpylarEKERIeKAGGSV-I---MQRVNGSLAVSRALGDFDYKRnnsipa
    ...||.||. . | |..  .|.||.|||. .|..| |.              |.||| .||| . .    .||.|.||||.| ||. ..       
....psssgaTavvalidpstgklyvanaGdsppllvrddgg..............ereri.vagglpslGilpgrvfgvlavslapGdlllly......

KEQLVSPEPEiDILPRDSENDEFLLLACDGIYDVMSNEEVMSYVRRQLELTanlekICNDLIDL
....|..||. ..  .. ..|||| ||.||..||.|..|... ||..||       ....|.. 
tDGvveaepd.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp.....aaeglleD
subfamily_ILKAP_pd Subfamily ILKAP 24-270 1e-43 142.6 In-house 7-271 (293) alignment 
Range on Protein: 24-270
Range on HMM: 7-271/293.0
YAVSAMQGWRMEMEDSHICDTD----------FIKNWSFFGVFDGHAGPKVSQYCSDHILRIMLDDLKAslDECKSTEepkERIKQAIYDGFLKLDSKIR
 |..  .| | ||.|.|.   |          .... |...|||||||.. |....... . .|. |    .. ...|   ..||... | | | |..  
gayaerkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpk..sdvsake...keikkclvdsfkktdeefL

EDPTWANGEDHSGTTAITVMISPTHIYWANCGDSRGFLCS---DGK---VKFATEDHKPYLAREKERIEKAGGSVIMQRVNGSLAVSRALGDFDYKRNNs
.  . |.     |.||..|..    .| || |||. .|.    .|.   .   | ||.|    |..||.||||.|   ||.| | |||..||  .||   
klaskakPvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfkrlG.

ipakeqlVSPEPEIDILPRdSENDEFLLLACDGIYDVMSNEEVMSYVRRQLELTAN----------------LEKICND
       |.  |..  .   .||| |..|||||...|.|..||....  .||   .                .| .|| 
.......vistPdvkkceL.tendlfvvlaCdGLwkvfsadevvkfilkvledeeddrkikeeekkskeevrfevacnr
subfamily_PPM1L_pd Subfamily PPM1L 25-293 1.7e-42 138.6 In-house 8-268 (269) alignment 
Range on Protein: 25-293
Range on HMM: 8-268/269.0
AVSAMQGWRMEMEDSHICDTDFIKN--WSFFGVFDGHAGPKVSQYCSDHILRIMLDDLKaSLDECKSTEEPKErIKQAIYDGFLKLDSKIREDPTWAngE
|| ...| | .|||  . ..|  ..   |||.||||| |   .... | . . ... |.  ||. |  .|| .  .. . |  | .| |. |  . |  |
avysvlGrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknkli.eldadkentepin.fsklltdeilsvdekllekakra..e

DHSGTTAITVMISPTHIYWANCGDSRGFLCS-DGKVKFATEDHKPYLAREKERIEKAGGSVIMQ---RVNGSLAVSRALGDFDYKRNNsipakeqLVSPE
| .||||.  ... ...  || ||||| |.  .||    . ||||.  .|. ||.|||| . ..   ||.| ||.||||||.  | .|       || ..
diaGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdkn.......lviad

PEIDILPRDSENDEFLLLACDGIYDVMSNEEVMSYVRRQLELTANlekICNDLIDLCLNKNSRDNMSVVLVVFPN
|.|  .  |  . |||.||.||..| .|||| . ... .|.           |.  . .. | ||..|..|.. |
pdiltfdlddhkpeflilasdGlwdtfsneeavrfikerlkepdf...GakslvlesfkrGsvdnitvlvvklkn
subfamily_PPM1D_pd Subfamily PPM1D 24-291 3.9e-39 127.6 In-house 4-307 (309) alignment 
Range on Protein: 24-291
Range on HMM: 4-307/309.0
YAVSAMQGWRMEMEDSHICDTDF-----IKNWSFFGVFDGHAGPKVSQYCSDHILRIMLDDLKAsldecksTEEPKERIKQAIYDGFLKLDSKIRED-PT
 ...| || |  |||     ..       ....|..||||| | . ... ..|..  . .. |        . ...| . .|| ..||.. .....    
vtseadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkf.......lssepedvleAireaflatheamkkklee

WANGED----HSGTTAITVMISPTHIYWANCGDSRGFLCSDGK------VKFATEDHKPYLAREKERIEKAGGSVIMQ----RV---------NGS----
|.. ..     .|||| .|.|  ...| |. |||. .| .. .       |  |.||||   .||||||..||.| ..    ||         ||     
WpktksgllstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngptvid

----LAVSRALGDFD-YkrnnSIPAKEQLVSPEPEIDILPRDSENDEFLLLACDGIYDVMSNEEVMSYVRRQLELTANL----EKICNDLIDLCLNKNSR
    |||.|.|||.  |    .   .| .|||||..    .| ....|..|| ||...|.. |...| |... | .       ... . |..  |.. ..
eiPFLavaRslGDlWsy....naksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrs

-----DNMSVVLVVF
     ||.||..|..
kklraDnvsvivvil
subfamily_PPM1K_pd Subfamily PPM1K 27-291 3.3e-37 121.0 In-house 9-258 (263) alignment 
Range on Protein: 27-291
Range on HMM: 9-258/263.0
SAMQGWRMEMEDsHICDTDFIKNWSFFGVFDGHAGPKVSQYCSDHILRImLDDLKaslDECKsteEPKERIKQAIYDGFLKLDSKIREDPTWAnGEDHSG
 ...| | | ||  |. ... ..  ...|||||||.   ... |.. .| | .|.   .. |   . .. .|.|  .   || . ..   . |  .  ||
dsliGkraened.riklkeldpellyvavfdGhaGsaaadfvhdkleki.lkrll...ekek...dleivlknafeeldkklkrylefsvaea.ellssG

TTAITVMI-SPTHIYWANCGDSRGFLCSDGKVKFATEDHKPYLAREKERIEKAGGSVIM-----QRVNGSLAVSRALGDFDYKRNNSIPakeqlvspEPE
|||  ...   |..  |. ||||  || .|| |  |.||.| |  ||||| .||||| .      .||| ||..|.|||.| ||   |         .||
ttatvsllrdGtelvlaslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryGvia........tPe

IDILPRDSENDEFLLLACDGIYDVMSNEEVMSYVRrqleLTANLEKICNDLIDLCLNKNSRDNMSVVLVVF
   |  | ..| ||.|  ||| .|....|.  .||    |  . |.  . | .  |.  | || ..|.| .
tkslkvdhaadsflvlitdgisfvvnsqelcdlvr....lchdpeeaahalteqalqygsednatavvvpl
subfamily_PPM1G_pd Subfamily PPM1G 4-115 4.4e-27 88.2 In-house 1-102 (473) alignment 
Range on Protein: 4-115
Range on HMM: 1-102/473.0
FLEKPKTDKVTSSGEGYGIRYAVSAMQGWRMEMEDSHICDTDFIKNWSFFGVFDGHAGPKVSQYCSDHILRIMLDDlkasldecKSTEEpkERIKQAIYD
.|.|||..| .. .   ...|..||||||| ..||.| | ||. ...|.|.|.||| | .|..|...... .. ..        |. .|  . ...|. .
ylskpkvekesedesneelsygasamqGwrvsqEDahncitdldedtslfavyDGHGGkevakyvakklpdllkaq........kgyke..gdvekalee

GFLKLDSKIRED
 ||.||.|....
aflalDeklkae
subfamily_KAPP-like_pd Subfamily KAPP-like 32-289 2e-26 85.6 In-house 8-264 (266) alignment 
Range on Protein: 32-289
Range on HMM: 8-264/266.0
WRMEMEDSHICDTDFIKN--------WSFFGVFDGHAGPKVSQYCSDHILRIMLDDLKAslDECKSTEEPKERIKQAIYDGFLKLDSKIREdptwangED
  .|||| ...   . |.         ..|.|||||||  ...  .. . ... . ||    . .   ...   .. . . | ..|.|...        .
cstemedvslaiypllkekklsncsnialfavfdGhaGkGaadaakklfpkelekllks..tkqddGGdniydqskllenafkevdaklkd.......fe

HSGTTAITVMI-S---PTHIYWANCGDSRGFLCSDGKVKFATEDHKPYLAREKERIEKAGGSVIM--QRVNGsLAVSRALGDFDYKRNNSIPAKEQLVSP
. |.||  ... |     ..  || |||  ||.   .  . . |||    .|| || . | ..     |.|| |||||||||   |. |   . |  ||.
yeGatatlalvwsdGqqrylqvanvGdssaflsrGneslelskdhkakdpeekqrikddGitlsdnqtrinG.lavsralGdhfikelniGlisepyvsn

epEIDILPRDSendeFLLLACDGIYDVMSNEEVMSYVRRQLELTANLEKICNDLIDLCLNK-NSRDNMSVVLV
  .| . | |.    ||..| ||..||.| .. .  |.   .  |  .|... |..  ..   ..||.||..|
..rilltpfdk....flivasdGlwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivv
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 32-289 1.6e-24 79.2 In-house 7-274 (276) alignment 
Range on Protein: 32-289
Range on HMM: 7-274/276.0
WRMEMEDSHICDTDFIK--------NWSFFGVFDGHAGPKVSQYCSDHILRIMLDDLKA---SLDECKSTEEPKERIKQAIYDGFLKLDSKIREDptwan
  .|||| ...   . .        | ..|.|||||||  ...  .. . ....  ||.   || . .   ...   .. . | | ..|.|...      
cstemedvslaiyplldekdlsncsnialfavfdGhaGkGaadaakklfpkelekllksgnysltkqddGGdniydqskllldlfkevdaklkdf.....

geDHSGTTAITVMI-SP---------THIYWANCGDSRGFLCSDGKVKFATEDHKPYLAREKERIEKAGGSVIM--QRVNGsLAVSRALGDFDYKRNNSI
  .. |.||  ... |           ..  || |||  ||.   .  . . |||     ||.|| . | ..     |.|| |||||||||   |. |  
..eyeGatatlalvwsdGeeqqqqqqrylqvanvGdssaflsrGneslelskdhkatdpeekqrikddGitlsdnqtrinG.lavsralGdhfikelniG

PAKEQLVSPepEIDILPRDSendeFLLLACDGIYDVMSNEEVMSYVRRQLELTANLEKICNDLIDLCLNK-NSRDNMSVVLV
 . |  ||.  .| . | |.    ||..| ||..||.| .. .  |.   .  |  .|... |..  ..   ..||.||..|
lisepyvsn..rilltpfdk....flivasdGlwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivv
subfamily_PDP_pd Subfamily PDP 90-281 4.7e-21 68.3 In-house 108-335 (398) alignment 
Range on Protein: 90-281
Range on HMM: 108-335/398.0
TEEPKERIKQAIYDGFLKLDSKIREDPT---WA-N-----GEDHSGTTAITVMISPTHIYWANCGDSRGFLCS---DGKVKFA--TEDHKPYLAREKERI
 |   | .|.|.  .|||||. |...        .         ||..|....|..|... || ||.|  |..   .|...    ..|.    ..| |||
leaevekvkealkkaFlklDkdistealkklkekslreallvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRi

EKAG-----GSVIM-QRVNGSLAVSRALGDFDYKRNNSIPA----K--EQLVSP-----------EPEIDILpRDSENDEFLLLACDGIYDVMSNEEVMS
.|.       .||. .|. |.|. .|| ||. || .. .      |   . . |           |||.    . .||| ||.|| ||..|..|||||.|
kkeHPgeesktvirngRlLgeLqPlRAFGdvryKwseelqkkvlekaylkvlepkdyktPPYltaePevtsh.klrendkFLvlatDGLwdllsneevvs

YVRRQLELTANLEKICNDLIDLCLNKNSR
.| . |. ... |..  .  .| |.. ..
lVgehlakkkekepvkveeakltlkqvve
subfamily_PP2D1_pd Subfamily PP2D1 121-261 5.5e-20 64.5 In-house 172-309 (492) alignment 
Range on Protein: 121-261
Range on HMM: 172-309/492.0
GEDHSGTTAITVMISPTHIYWANCGDSRGFLCSDGKVKFATEDHKPYLAREKERIEKAGGSVIM----QRVNGSLAVSRALGDFDYkrnnsiPAKEQLVS
| ...  .    .. .. .| || |. .  || .|| .  | .| |.  .|..|.||||..|       .||| | . | || .        |  .. | 
GlekesngsevhleelgvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGd......pkLkksvi

PEPEIDILPRDsENDEFLLLACDGIYDVMSNEEVMSYVRRQLELT
|||..   . | |.. ||.||  |...|.|.|||.| |.  |.. 
pePkttsvkld.eaaqflvlAsnGlWevlseeevlsLvkqtlaiy
PP2C_SIG_SM00331 52-289 2.9e-18 59.2 In-house 32-215 (217) alignment 
Range on Protein: 52-289
Range on HMM: 32-215/217.0
FFGVFDGHAgpkvSQYCSDHILRIMLDDLKASLDECKSTEEPKERIKQAIYDGflkldskiredptwaNGEDHSGTTAITVMI--SPTHIYWANCGDSRG
.. |.||.     . ...  . . ... |. .|.| .....  .|. .|||.                ..|.....|..  ..  |  ... ||.|||| 
llvvaDgmG....kGlaAaaassqlrtalrellsegeelsqalkrlnraiyee...............keekgmfaTlllalydfssgklsyanaGdsrp

FLCSDGKVKFATEDhkpylarekeriekaggsvimqrvngslavsralgdfdykrnnsipAKEQLVS--PEPEIDILPRDSENDEFLLLACDGIYDVMSN
.|  ||| .. ..|                                               . ....  ||...||  .. | ...|||. ||. ...| 
yllrdgklveilkd..............................................vegaplGlepevsvdirelelekgdllllytDGltearse

-----EEVMSYVRRQL--ELTANLEKICNDLIDLCLNKNSRDNMSVVLV
     |...  ..  .  |. .  .|| ..|. |  ..| .|...||.|
kgfaeerleeiledlvdseaqelaqkiveellelakgsngeDdiTvvvv
PPM_PTC7_motif 235-284 2.2e-14 46.7 In-house 1-51 (51) alignment 
Range on Protein: 235-284
Range on HMM: 1-51/51.0
LLACDGIYDVMSNEEVMSYVRRQLELT-ANLEKICNDLIDLCLNKNSRDNM
.||.||..||.|..|. . ||.||. .   .......|.| .|...| ||.
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 52-202 1.1e-13 44.3 In-house 22-185 (292) alignment 
Range on Protein: 52-202
Range on HMM: 22-185/292.0
F-FGVFDGHA--GPKVSQYCSDHILRIMLddlkasldeckSTEEPKERIKQAIYDGFLKLDSKIREDptWANGEdHSGTTAITVMISPTH--IYWANCGD
|   |.|||   | ||.|.  |..   .|           ..  ..  . .|.  . |.. .|...    ..    |.|||..  . .    .. || ||
flaavldGhGvnGdkvaqlaedtlevell...........eltrqlqelsealllrildiaakldkl..tidar.esattavvcarvrddralilanvGd

SRGFLCS-----DGKVKFATEDHKPYLAREKERIEKAGGSVI-----------MQRV------NGSLAVSRALGDFDY
||  |       | ...  . ||||    |..|| .||| |              ||      .| ||.|||||||  
srallgrclggsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdfhl
PP2C_C Protein serine/threonine phosphatase 2C, C-terminal domain 285-360 1.4e-12 37.1 Pfam-A 1-76 (81) alignment 
Range on Protein: 285-360
Range on HMM: 1-76/81.0
SVVLVVFPNAPKVSQEAIEKEKILQKEAQEKIEEKLKEMVKAANDPL-EVEENyILQQLIQEFPDNYCVPAKKSFIS
|..||.||.|||||.||..||. |.|  ....|| .... .   . | .| .. . .. | . |    . .|.| |.
siilvcfpgAPkvseeAvkkeaeLdkalesrveeiieksseeevpdllsvlkt.lasedipnLPPGGglasKrsvie
Subfamily Dicty-PPM1L-like 167-291 1.7e-12 39.8 In-house 178-303 (305) alignment 
Range on Protein: 167-291
Range on HMM: 178-303/305.0
YLAREKERIEKAGGSVIMQ---RVNGSLAVSRALGDFDYKrnnsipakeQLVSPEPEIDILPRDSENDEFLLLACDGIYDVMSNEEVMSYVRRQLELTAN
.|  .. ||| ......     .||. | .||  || . |         .|| |...  .|     ||.||.|| ||...|.|...|   |.. |. .  
fldeiririeslqaalynygellvnrllkksrskGdknlk.........elviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkss

LE-------KICNDLIDLCLNKNSRDNMSVVLVVF
 .        | .    . ....|.||. .|.. .
qkkiewdfneisrviveeavkrgsgDnitlviikl
subfamily_TAB1_pd Subfamily TAB1 125-273 4.5e-11 35.1 In-house 129-297 (333) alignment 
Range on Protein: 125-273
Range on HMM: 129-297/333.0
SGTTAITVMISPTHIYWANCGDSRGFLCS---DGKVKFATEDHKPYLAREKERIEKAGGS---VIMQRVNGSLAVSRALGDFDYKR----NNSI-PAKEQ
 ||||. ..|   ..| ||.||||  |.      |||    ||.     | .|... |     .  ... ||    |..||.  |     .. .  ||..
gGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkkgykdvdilssakge

LVSPEPEIDILPRDSENDEFLLLACDGIYDVMSN--------EE-VMSYVRRQLELTANLEKICNDLID
 |  ||.|       .   ||.|  ||.|  . .         | ..  |  .||  |.|... ....|
PviaePdiqgaypiddityflvlmSdGvyktLeevtgpetsnvenillevitelekqatlqdvAqavvd
subfamily_PPM1H_pd Subfamily PPM1H 185-262 4.6e-11 35.1 In-house 275-355 (404) alignment 
Range on Protein: 185-262
Range on HMM: 275-355/404.0
QRVNGSLAVSRALGDFDYKRNNSIPAKEQLVSPEPEI---DILPRDSENDEFLLLACDGIYDVMSNEEVMSYVRRQLELTA
.|. . ..|.| ||| . |  ..      ..||.||.   |.   .|..|. |.|| ||..||.|||||   ||. |. . 
aRllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskve
PP2C_2 Protein phosphatase 2C 48-258 4.4e-10 32.2 Pfam-A 22-195 (212) alignment 
Range on Protein: 48-258
Range on HMM: 22-195/212.0
KNWSFFGVFDGHAGPKVSQYCSDHILRIMLDDLKASLDECKST--EEPKERIKQAIYDGFLkldSKIREDPTWANGEDhSGTTAITVMISPTHIYWANCG
...... | ||.   | |.  .    ..... |...|.| . .  |.  ..|...|.        | ..  .... .|  .|| . ..|.|..|.....|
sdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvk...lkqeaeaqqeelkd.yatTlllavitpgeivffqiG

DSRG-FLCSDGKVKFATEDHKPYLAREKERIEKA--GGSVimqrvngslavsralgdfdykrnnsipakeqlvspepEIDILPrdSENDEFLLLACDGIY
|..  .  .||.|. ..|...   |.|  .. ..  ....                                     .| .|.   |  . |||  ||. 
Dgaivvrdrdgevqllgepdsgeyanettfltsedaeeel.....................................rirrlk..lepgdalllmTDGvs

DVMSNEE-VMSYVRRQL
| ...|| ........|
dslrkeepfrellaell
PP2C_2 Protein phosphatase 2C 48-258 4.4e-10 32.2 In-house 22-195 (212) alignment 
Range on Protein: 48-258
Range on HMM: 22-195/212.0
KNWSFFGVFDGHAGPKVSQYCSDHILRIMLDDLKASLDECKST--EEPKERIKQAIYDGFLkldSKIREDPTWANGEDhSGTTAITVMISPTHIYWANCG
...... | ||.   | |.  .    ..... |...|.| . .  |.  ..|...|.        | ..  .... .|  .|| . ..|.|..|.....|
sdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvk...lkqeaeaqqeelkd.yatTlllavitpgeivffqiG

DSRG-FLCSDGKVKFATEDHKPYLAREKERIEKA--GGSVimqrvngslavsralgdfdykrnnsipakeqlvspepEIDILPrdSENDEFLLLACDGIY
|..  .  .||.|. ..|...   |.|  .. ..  ....                                     .| .|.   |  . |||  ||. 
Dgaivvrdrdgevqllgepdsgeyanettfltsedaeeel.....................................rirrlk..lepgdalllmTDGvs

DVMSNEE-VMSYVRRQL
| ...|| ........|
dslrkeepfrellaell
subfamily_Choan-PPM-1_pd Subfamily Choan-PPM-1 123-292 3.2e-09 28.4 In-house 133-316 (317) alignment 
Range on Protein: 123-292
Range on HMM: 133-316/317.0
DHSGTTAITVMISPTHIYWANCGDS---------RGFLCSDG-KVKFATEDHKPYLAREKERIEKAGGSVIMQRVNGSLAVS-RALGDFDYKRNNSIPAK
|.  |....|..  ||.  || ||.          | .  || .|.. .  |.   . |..|.... .       .| ||.   || ... .   |.  |
dfGttavvavvvdethvvvanaGdaaalvllrdqaghedrdGlsvealsvrhtlrskaerarvaevlpgaahvtedgylaildealaayelqltkslGhk

---EQLVSPEPEIDILPRDSENDEFLLLACDGIYDVMSNEEVMSYVRRQLELTANLEKICNDLIDLCLNKNSRDNMSVVLVVFP
      |. .||.     | ..   ..   ||| | .....|.  | |        |..|.|  | .|...| |. . |....|
llkraGviadPevrsrvldvdevfavvvvsdGitdelkrldvldrvlraataleasevlcddaqdylldetsiddatavvlllp
subfamily_PP2D1_pd Subfamily PP2D1 32-103 2.3e-08 26.2 In-house 13-85 (492) alignment 
Range on Protein: 32-103
Range on HMM: 13-85/492.0
WRMEMEDSHICDTDFIK--NWSFFGVFDGHAGPKVSQYCSDHILRIMLDDLKaSLDECKSTEEPKERIKQAIYD
|. .||| .    .|    | .|||..||. |    . .. .. ...|..|. ..||  |    ...|... . 
WKskmeDkrtlqdyfgndvnscFfgiyDGynGataAeiaakelhevlleele.kvdervslttavnlidnndlt
subfamily_PPM1H_pd Subfamily PPM1H 97-171 2.7e-08 26.0 In-house 136-208 (404) alignment 
Range on Protein: 97-171
Range on HMM: 136-208/404.0
IKQAIYDGFLKLDSKIREDPTwaNGEDHSGTTAITVMISPTHIYWANCGDSRGFLCSDGKVKFATEDHKPYLARE
.. |. . ||..|..|... .  . ... | ||. ...    .| || ||||  |.  ....   .|. |   |.
viGalesaflemDeqiarere..ayrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftPeteRq
PPM_PTC7_SpoIIE_motif 230-289 6.6e-08 26.1 In-house 11-78 (81) alignment 
Range on Protein: 230-289
Range on HMM: 11-78/81.0
NDEFLLLACDGIY-------DVMSNEEVMSYVRRQleL--TanLEKICNDLIDLCLNKN---SRDNMSVVLV
... |||..||..       .....||......|.     .  |....  |.| .|. .   ..|.......
pgdvllLyTDGltEardsdgelfgkeellrladra..egks..lqeladklvdevlengsgereDDitllvl
subfamily_PHLPP_pd Subfamily PHLPP 49-289 4.4e-07 22.0 In-house 26-243 (246) alignment 
Range on Protein: 49-289
Range on HMM: 26-243/246.0
NWSFFGVFDGHAgpkvSQYCSDHILRIMLDDLKASLDECKSTeepKERIKQAiydgFLKLDSKIREDptwanGEdHSGTTAITVMISP--------THIY
. . .|.|||..    ... |  . |.| | ||  . . |.    .| .|.     .|.   |. |.     || . |..|. ..| .          . 
vealyGlfdGdr....neelssllqrlmkdvlkeevqkdkne...eeymknt....llvaqrklGea.....Ge.klgsaallilirhdkvdPaksfsLe

WANCGDSRGFLCSDGKvKFATEDHKPYLAREKERIEKAGGSVIM-QRVNGSLAVSRALGDFdykrnNSIPakeqLVSPEPEIDILPRdSENDEFLLLACD
 |. |     |. .|| |.  . .      | .|| .| . .   ...|| .. .| || .        |     | |.|..  ..  .|.||.|..  .
vAsvGtlqavliRngk.klrlsksyviekdelkrikeakaiitednkingviestrllGyt.....flfP....vvlPkphvrevlL.teqdellivGnk

GIYDVMSNEEVMSYVRRQLELTANLEKICndliDLCLNKNSRDNMSVVLV
 ...|.| .|. . ||.. .  .   |..    ||    . .|..||. |
alWevlsideaveavrkeedplvaAkklv....dlaqsygaadsvsvlvv
SpoIIE Stage II sporulation protein E (SpoIIE) 115-289 7.2e-07 21.2 Pfam-A 58-190 (193) alignment 
Range on Protein: 115-289
Range on HMM: 58-190/193.0
DptwangedHSGTTAITVMI--SPTHIYWANCGDSRGFLCSD-GKVKFATEDHKPYLAREKEriekaggsvimqrvngslavsralgdfdykrnnsipak
.        . ..||. . .  |  ....||.|..  .|... |..|| .... . |  ..|                                      
e........erfatavlaeydpstgkleyanaGhpppllvrpdggtkfllvstglplGilpe......................................

eqlvspePEIDILPRDSENDEFLLLACDGIYDVMSNEEVMSYVRRQLELTA--N---LEKICNDLIDLCLN-K--NSRDNMSVVLV
        ...    . |... |||. ||... .. .. .    |.|.| |      ||.... |.. .|. .  . .| ......
.......adyeeaelqlepgdllllyTDGvtEardpdgelfgkerllallaeaegesleelldalveellelgsgeleDDitllvl
SpoIIE Stage II sporulation protein E (SpoIIE) 115-289 7.2e-07 21.2 In-house 58-190 (193) alignment 
Range on Protein: 115-289
Range on HMM: 58-190/193.0
DptwangedHSGTTAITVMI--SPTHIYWANCGDSRGFLCSD-GKVKFATEDHKPYLAREKEriekaggsvimqrvngslavsralgdfdykrnnsipak
.        . ..||. . .  |  ....||.|..  .|... |..|| .... . |  ..|                                      
e........erfatavlaeydpstgkleyanaGhpppllvrpdggtkfllvstglplGilpe......................................

eqlvspePEIDILPRDSENDEFLLLACDGIYDVMSNEEVMSYVRRQLELTA--N---LEKICNDLIDLCLN-K--NSRDNMSVVLV
        ...    . |... |||. ||... .. .. .    |.|.| |      ||.... |.. .|. .  . .| ......
.......adyeeaelqlepgdllllyTDGvtEardpdgelfgkerllallaeaegesleelldalveellelgsgeleDDitllvl
Subfamily Dicty-PPM1L-like 23-78 2.4e-06 19.6 In-house 8-65 (305) alignment 
Range on Protein: 23-78
Range on HMM: 8-65/305.0
RYAVSAMQGWRMEMEDSHICDTDFIK--NWSFFGVFDGHAGPKVSQYCSDHILRIMLD
.| . . .. |   || .       .  . |.||||||| | . ..|   ... |.  
kyelyvsansrkyqedrnkvkislessqelslfGvfdGhnGdiaaeyvkkklveivnk