Gene PPM1A in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1A
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP207_AA protein Get Run
AqueP207_AA_3-294 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1A_pd Subfamily PPM1A 12-293 3.7e-119 390.3 In-house 2-282 (282) alignment
Range on Protein: 12-293
Range on HMM: 2-282/282.0
KVTSSGEGYGIRYAVSAMQGWRMEMEDSHICDTDF--IKNWSFFGVFDGHAGPKVSQYCSDHILRIMLDdlKASLDECKSTEEPKERIKQAIYDGFLKLD
| .|..|| |.||.||.|||||.||||.|.. ...  .|.|||| ||||||| .|..|...|.|. .|.  . .| |.......|...|.|. .|||.||
kpksqaegnglrygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenile..eeelkeaaleasekdevkealrqgfLald

SKIREDPTWANGEDHSGTTAITVMISPTHIYWANCGDSRGFLCSDGKVKFATEDHKPYLAREKERIEKAGGSVIMQRVNGSLAVSRALGDFDYKRNNSIP
..|||. |.....|.||.||.||..|..|...||.||||..||..||..|.||||||. ..||.|||.|||||...||||.|||||||||..||.... .
eairelstdlktadksGsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDyeykeeeekk

AKEQLVSPEPEIDILPRDSENDeFLLLACDGIYDVMSNEEVMSYVRRQLELTANLEKICNDLIDLCLNKNSRDNMSVVLVVFPN
|.|||||.|||. .. |..|.| ||.||||||.||.|.|||...||..|| . .||.....|.| .|.|.||||.||..|.|..
aeeqlvsaepevtsierseedd.flvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsrDNlsvlvvlfak

0034914 PP2C-like 4-294 1.4e-89 292.6 In-house 3-293 (295) alignment
Range on Protein: 4-294
Range on HMM: 3-293/295.0
FLEKPKTDKVTSSGEGYGIRYAVSAMQGWRMEMEDSHICDTDF---IKNWSFFGVFDGHAGPKVSQYCSDHILRIMLDDLKASldeCKSTEEPKERIKQA
.|..|.......| . . .|..|. .||.|...||.... ...    .....||||||| | ......|.......|. |.     . ..... | |..|
llslpllellllsslllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekl...lllltlsledieea

IYDGFLKLDSKIREDPTWANGEDHSGTTAITVMISPTHIYWANCGDSRGFLCSDGKVKFATEDHKPYLAREKERIEKAGGSVIMQRVNGSLAVSRALGDF
....||..| ...|   . .  ..|||||....| ....|.||.|||| .|...|.... |.||||.   |.|||..||| |.. ||||.|||.||||||
lrkaflaadeellelallrpelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdf

DYKRNNSIPAKEQLVSPEPEIDILPRDSENDEFLLLACDGIYDVMSNEEVMSYVRRQLELTANLEKICNDLIDLCLNKNSRDNMSVVLVVFPNA
|.|...| ...|.|||.||....|... |.|.|||||.||..||.||||....||. |. . .||.... |.||.|...||||..||.| ... 
dlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTvvvvrlngl

subfamily_PPM1G2_pd Subfamily PPM1G2 5-291 2.3e-87 285.6 In-house 2-286 (287) alignment
Range on Protein: 5-291
Range on HMM: 2-286/287.0
LEKPKTDKVTSSGEGYGIRYAVSAMQGWRMEMEDSHICDTDFIK-----NWSFFGVFDGHAGPKVSQYCSDHILRIMLDdlkasldecKSTEEpKERIKQ
|..| ..| ..|..   .. . |||||.|..|||.|| ......     . ..|.||||| | ||..|.. .. ...           |.. . .. ..|
lsepvvakesascanaltkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiak.........kksfk.egaleq

AIYDGFLKLDSKIREDPTWANgeDHSGTTAITVMISPTHIYWANCGDSRGFLCSDGKVKFATEDHKPYLAREKERIEKAGGSVIMQRVNGSLAVSRALGD
.. |.||..|.....| . ..  ...|.||..|.|. ...| ||.||||  |.|.|.||  . ||||  . ||.||..||| | ..||||.||.||||||
ilkdafletDeellkdeklkd..esaGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfvelnrvngnLalsralgD

FDYKRNNSIPAKEQLVSPEPEIDILPRDsENDEFLLLACDGIYDVMSNEEVMSYVRRQLELTANLEKICNDLIDLCLNKNSR------DNMSVVLVVF
| .|.|......||.|  .|.. .  .| |.||||.||||||.||..|.||. .|| .|   |.|..|...|.| ||...|.      |||.||.||.
fefkknvkkkpeeqivtavPDvlvkkld.eddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvvivvl

PP2Cc_SM00332 15-289 2.1e-82 269.6 In-house 3-274 (274) alignment
Range on Protein: 15-289
Range on HMM: 3-274/274.0
SSGEGYGIRYAVSAMQGWRMEMEDSHICDTDFI--KNWSFFGVFDGHAGPKVSQYCSDHILRIMLDDLKASLDECksteepKERIKQAIYDGFLKLDSKI
.||.. |..|..|.||||| .||| |.. .|.   ..|.||||||||.|..|....|... ... . ||  .||       .. ...|....||..|..|
esgsnlglsygkssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdel......eddveealkkaflstdeei

REDPTWANGE-DHSGTTAITVMISPTHIYWANCGDSRGFLCSDGKVKFATEDHKPYLAREKERIEKAGGSVIMQRVNGSLAVSRALGDFDYKRNNsiPAK
.|.    . |   ||.||......  ..| ||.|||| .||..||..  ..||||  ..|..||.||||.|. .||||.||||||.||...|.|.  . |
leeeqskelenalsGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdhflkknk..klk

EQLVSPEPEIDILPRdSENDEFLLLACDGIYDVMSNEEVMSYVRRQL--ELTANLEKICNDLIDLCLNK-NSRDNMSVVLV
|. ...||.. ..    ..||||.||.||..||.||.|| ..||..|  . | . ......|....... .|.||..||.|
epyitaepdvkvvtl.tsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv

PP2C Protein phosphatase 2C 23-284 1.8e-81 266.4 Pfam-A 2-255 (255) alignment
Range on Protein: 23-284
Range on HMM: 2-255/255.0
RYAVSAMQGWRMEMEDSHICDTDFI-----KNWSFFGVFDGHAGPKVSQYCSDHILriMLDDLKASLDECKsteepkeRIKQAIYDGFLK-LDSKIREDP
.. .|..||.|..|||.||.  ..      ....||.|||||.| ....|.. |.    . ... |..|..         ..|....||. .|.... . 
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehle..eilkeqksflele.......kvekalrksfladtdeelkssk

TWAnGEDHSGTTAITVMISPTHIYWANCGDSRGFLCSDGKVK-FATEDHKPYLAREKERIEKAGGSVI-MQRVNGSLAVSRALGDFDYKRNNsipakEQL
. .  ...||.||....|.....| ||.||||  ||.... | . ||||||.  .|.||||.|||||. ..|||||||||||||||..|...     |||
ant.epsksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eql

VSPEPEIDILPRDSEnDEFLLLACDGIYDVMSNEEVMSYVRRQLELTANLEKICNDLIDLCLNKNSRDNM
||.||..   ....| ||||.||.||..||.|..|... ||..|. . ........|.| .....|.||.
vsaePdvtsvkltee.defliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni

PP2C Protein phosphatase 2C 23-284 1.8e-81 266.4 In-house 2-255 (255) alignment
Range on Protein: 23-284
Range on HMM: 2-255/255.0
RYAVSAMQGWRMEMEDSHICDTDFI-----KNWSFFGVFDGHAGPKVSQYCSDHILriMLDDLKASLDECKsteepkeRIKQAIYDGFLK-LDSKIREDP
.. .|..||.|..|||.||.  ..      ....||.|||||.| ....|.. |.    . ... |..|..         ..|....||. .|.... . 
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehle..eilkeqksflele.......kvekalrksfladtdeelkssk

TWAnGEDHSGTTAITVMISPTHIYWANCGDSRGFLCSDGKVK-FATEDHKPYLAREKERIEKAGGSVI-MQRVNGSLAVSRALGDFDYKRNNsipakEQL
. .  ...||.||....|.....| ||.||||  ||.... | . ||||||.  .|.||||.|||||. ..|||||||||||||||..|...     |||
ant.epsksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eql

VSPEPEIDILPRDSEnDEFLLLACDGIYDVMSNEEVMSYVRRQLELTANLEKICNDLIDLCLNKNSRDNM
||.||..   ....| ||||.||.||..||.|..|... ||..|. . ........|.| .....|.||.
vsaePdvtsvkltee.defliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni

PPM_PTC7 23-284 2.7e-80 262.5 In-house 2-259 (259) alignment
Range on Protein: 23-284
Range on HMM: 2-259/259.0
RYAVSAMQGWRMEMEDSHICDTDFI-----KNWSFFGVFDGHAGPKVSQYCSDHILriMLDDLKASLDECKsteepkeRIKQAIYDGFLK--LDSKIRED
.. .||.||.|..|||.||.  ..      ....||.|||||.| ....|.. |.      ... |..|..         ..|....||.  .|.... .
dggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehle..eilkerksfeele.......klekalrksflaldtdeelkss

PTWAnGEDHSGTTAITVMISPTHIYWANCGDSRGFLCSDGKVK-FATEDHKPYLAREKERIEKAGGSVI---MQRVNGSLAVSRALGDFDYKRNNSipaK
 . . ....||.||....|.....| ||.||||  ||..|... . ||||||.. .|.||||.|||||.   ..||||.||||||.|||..|.. .   .
eant.epstsGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpket...e

EQLVSPEPEIDILPRDSEnDEFLLLACDGIYDVMSNEEVMSYVRRQLELTaNLEKICNDLIDLCLNKNSRDNM
|||||.||.|   ..|.| ||||.||.||..||.|..|. . ||..|. .  .......|.| .....|.||.
eqlvsaePdisstkidee.defliLasdGlwdvvsdqeavdlvrselskk.dpmeaaeklvdeaiargsedni

0049733 PP2C-like 22-291 5.8e-62 201.9 In-house 3-233 (235) alignment
Range on Protein: 22-291
Range on HMM: 3-233/235.0
IRYAVSAMQGW-RMEMEDSHICdtdfikNWSFFGVFDGHAGPKVSQYCSDHILRIMLDDLKAsldecksteEPKERIKQAIYDGFLKLDSKIREDPTWAN
...... ..|. | ..||....      ....|.|.||| |  .....|.......|. |..          . . ...|... ||.... ..|  .  .
lsvgaasdigrvrkvneDavlv......glllfavaDGhgghaagevasellvetllellle.........lllldleealrkaflaaneallelalasp

GEDHSGTTAITVMISPTHIYWANCGDSRGFLCSDGKVKFATEDHKPYLAREKERIEKAGGSVimqRVNGSLAVSRALGDFDYKrnnsipakeqlvspepe
. ...||||..... . ..|.||.|||| .|..|||. . ||||.|.   |..||..||| |   ||.|.||..|||||...|                 
elagmgtTavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav...rvpgrlaltralGdlllk.................

IDILPRDSENDEFLLLACDGIYDVMSNEEVMSYVRRqleltANLEKICNDLIDLCLNKNSRDNMSVVLVVF
.|.   . |...|||||.||..||.|.||.....|.      .||.... |..|.|....|||..||.| .
pdvtvlelepgdflllasDGlwdvlsdeeivdllrs.....ldleeaaerlvelalarggrDNiTvvvvrl

subfamily_PPM1E_pd Subfamily PPM1E 24-291 6.5e-52 169.3 In-house 6-262 (265) alignment
Range on Protein: 24-291
Range on HMM: 6-262/265.0
YAVSAMQGWRMEMEDSHICDTDF--------IKNWSFFGVFDGHAGPKVSQYCSDHILRIMLDDLKASLDECksteepkerikQAIYDGFLKLDSKIRED
  . |... |  ||| |..  |.         |. .||.|||||.| . ..| . |. . . .. |.  |             .|. ..| ..|... . 
vsiaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa...........ealkeafkltDerflqk

PtwANGEDHSGTTAITVMISPTHIYWANCGDSRGFLCSDGKVKFATEDHKPYLAREKERIEKAGGSVIM---QRVNGSLAVSRALGDFDYKrnnsipake
   .. . .||.||..|.|.  ..| |  |||...|...|..   .. |||   .||.|||.||| |..    ||||.|.||||.|| ..|         
a..ereklksGstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklk.........

QLVSPEPEIDILPRDSEnDEFLLLACDGIYDVMSNEEVMSYVRRQLELTA-NLEKICNDLIDLCLNKNSRDNMSVVLVVF
. || |...  .. |.. .|.|.|||||..||. .|||.. |.  |. .| .|... . |..   ...|.||..||.|..
pyvsgeadvaeveldgs.eeylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvvfl

subfamily_PPM1G_pd Subfamily PPM1G 121-291 2e-50 165.2 In-house 293-470 (473) alignment
Range on Protein: 121-291
Range on HMM: 293-470/473.0
GEDhSGTTAITVMISPTHIYWANCGDSRGFLCSDGKVKFATEDHKPYLAREKERIEKAGGSVIM-QRVNGSLAVSRALGDFDYKRNNSIPAKEQLVSPEP
||| |||||. ...   ... || ||||  |...||     .||||    |.|||||||| | .  |||| | .||||||. ||.|...|.|||..|  |
Ged.sGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplkeqmisAlP

EIDILPRdSENDEFLLLACDGIYDVMSNEEVMSYVRRQLELTA--NLEKICNDLIDLCLNKNSR------DNMSVVLVVF
.| .|    |.|||| ||||||..||. .||. .|| .|. .    |..|...|.| || ..        |||.|..|..
Dikvltl.teedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtviivll

subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 24-292 1.8e-48 158.1 In-house 8-254 (255) alignment
Range on Protein: 24-292
Range on HMM: 8-254/255.0
YAVSAMQGWRMEMEDSHICDTDFIKN--WSFFGVFDGHAGPKVSQYCSDHILRIMLDDLKAsldecKSTeEPKERIKQAiydgFLKLDSKIREDPtwang
 . | | | |  |||. .    | ..    .. .||||.| . ....|... .|. . |..     ... .|.. .|.|    . ... .| | |     
vgfsdmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelykilaelldl.....nna.nPvkslkka....ykeistqiserp.....

eDHSGTTAITVMISPTHIYWANCGDSRGFLC-SDGKVKFATEDHKPYLAREKERIEKAGGSVIMQ----RVNGSLAVSRALGDFdYKrnnsipakEQLVS
  . ||||..|.|   ..| || ||||  ||  ||  |  . ||||   .|..||...|| |. .    |||| |||||||||  .         |  | 
.kfiGttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGds.fl........ePfvv

PEPEIDILPRDSENDEFLLLACDGIYDVMSNEEVMSYVRRqlelTANLEKICNDLIDLCLNKNSRDNMSVVLVVFP
|.|...   . |..|.||.||||||.|..|.|| .. |       .. || .. | ||  .. | ||.||... ..
pdPdlsqsleiskkdkflilacdGiwdlisdeeaveivag....isdpekaaeklrdlayssGstdnisvivikls

PPM_PTC7_SpoIIE 23-274 7.3e-45 146.5 In-house 2-220 (230) alignment
Range on Protein: 23-274
Range on HMM: 2-220/230.0
RYAVSAMQGWRMEMEDSHICDTDFI-----KNWSFFGVFDGHAGPKvsQYCSDHILRIMLDDLKASLDecksteepkeRIKQAIYDGFLKLDSKIREDpt
.. .||.||.| .|||.||.  ..        . ..|..||| |.   .... ..  ..    .|.|.            ........|.|. .....  
dggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrelafagle..........kpeeilrrlnlalaadlede..

wangEDHSGTTAITVMISPTH--IYWANCGDSRGFLCSD-GKvkfatedhkpylarEKERIeKAGGSV-I---MQRVNGSLAVSRALGDFDYKRnnsipa
    ...||.||. . | |..  .|.||.|||. .|..| |.              |.||| .||| . .    .||.|.||||.| ||. ..       
....psssgaTavvalidpstgklyvanaGdsppllvrddgg..............ereri.vagglpslGilpgrvfgvlavslapGdlllly......

KEQLVSPEPEiDILPRDSENDEFLLLACDGIYDVMSNEEVMSYVRRQLELTanlekICNDLIDL
....|..||. ..  .. ..|||| ||.||..||.|..|... ||..||       ....|.. 
tDGvveaepd.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp.....aaeglleD

subfamily_ILKAP_pd Subfamily ILKAP 24-270 1e-43 142.6 In-house 7-271 (293) alignment
Range on Protein: 24-270
Range on HMM: 7-271/293.0
YAVSAMQGWRMEMEDSHICDTD----------FIKNWSFFGVFDGHAGPKVSQYCSDHILRIMLDDLKAslDECKSTEepkERIKQAIYDGFLKLDSKIR
 |..  .| | ||.|.|.   |          .... |...|||||||.. |....... . .|. |    .. ...|   ..||... | | | |..  
gayaerkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpk..sdvsake...keikkclvdsfkktdeefL

EDPTWANGEDHSGTTAITVMISPTHIYWANCGDSRGFLCS---DGK---VKFATEDHKPYLAREKERIEKAGGSVIMQRVNGSLAVSRALGDFDYKRNNs
.  . |.     |.||..|..    .| || |||. .|.    .|.   .   | ||.|    |..||.||||.|   ||.| | |||..||  .||   
klaskakPvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfkrlG.

ipakeqlVSPEPEIDILPRdSENDEFLLLACDGIYDVMSNEEVMSYVRRQLELTAN----------------LEKICND
       |.  |..  .   .||| |..|||||...|.|..||....  .||   .                .| .|| 
.......vistPdvkkceL.tendlfvvlaCdGLwkvfsadevvkfilkvledeeddrkikeeekkskeevrfevacnr

subfamily_PPM1L_pd Subfamily PPM1L 25-293 1.7e-42 138.6 In-house 8-268 (269) alignment
Range on Protein: 25-293
Range on HMM: 8-268/269.0
AVSAMQGWRMEMEDSHICDTDFIKN--WSFFGVFDGHAGPKVSQYCSDHILRIMLDDLKaSLDECKSTEEPKErIKQAIYDGFLKLDSKIREDPTWAngE
|| ...| | .|||  . ..|  ..   |||.||||| |   .... | . . ... |.  ||. |  .|| .  .. . |  | .| |. |  . |  |
avysvlGrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknkli.eldadkentepin.fsklltdeilsvdekllekakra..e

DHSGTTAITVMISPTHIYWANCGDSRGFLCS-DGKVKFATEDHKPYLAREKERIEKAGGSVIMQ---RVNGSLAVSRALGDFDYKRNNsipakeqLVSPE
| .||||.  ... ...  || ||||| |.  .||    . ||||.  .|. ||.|||| . ..   ||.| ||.||||||.  | .|       || ..
diaGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdkn.......lviad

PEIDILPRDSENDEFLLLACDGIYDVMSNEEVMSYVRRQLELTANlekICNDLIDLCLNKNSRDNMSVVLVVFPN
|.|  .  |  . |||.||.||..| .|||| . ... .|.           |.  . .. | ||..|..|.. |
pdiltfdlddhkpeflilasdGlwdtfsneeavrfikerlkepdf...GakslvlesfkrGsvdnitvlvvklkn

subfamily_PPM1D_pd Subfamily PPM1D 24-291 3.9e-39 127.6 In-house 4-307 (309) alignment
Range on Protein: 24-291
Range on HMM: 4-307/309.0
YAVSAMQGWRMEMEDSHICDTDF-----IKNWSFFGVFDGHAGPKVSQYCSDHILRIMLDDLKAsldecksTEEPKERIKQAIYDGFLKLDSKIRED-PT
 ...| || |  |||     ..       ....|..||||| | . ... ..|..  . .. |        . ...| . .|| ..||.. .....    
vtseadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkf.......lssepedvleAireaflatheamkkklee

WANGED----HSGTTAITVMISPTHIYWANCGDSRGFLCSDGK------VKFATEDHKPYLAREKERIEKAGGSVIMQ----RV---------NGS----
|.. ..     .|||| .|.|  ...| |. |||. .| .. .       |  |.||||   .||||||..||.| ..    ||         ||     
WpktksgllstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngptvid

----LAVSRALGDFD-YkrnnSIPAKEQLVSPEPEIDILPRDSENDEFLLLACDGIYDVMSNEEVMSYVRRQLELTANL----EKICNDLIDLCLNKNSR
    |||.|.|||.  |    .   .| .|||||..    .| ....|..|| ||...|.. |...| |... | .       ... . |..  |.. ..
eiPFLavaRslGDlWsy....naksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrs

-----DNMSVVLVVF
     ||.||..|..
kklraDnvsvivvil

subfamily_PPM1K_pd Subfamily PPM1K 27-291 3.3e-37 121.0 In-house 9-258 (263) alignment
Range on Protein: 27-291
Range on HMM: 9-258/263.0
SAMQGWRMEMEDsHICDTDFIKNWSFFGVFDGHAGPKVSQYCSDHILRImLDDLKaslDECKsteEPKERIKQAIYDGFLKLDSKIREDPTWAnGEDHSG
 ...| | | ||  |. ... ..  ...|||||||.   ... |.. .| | .|.   .. |   . .. .|.|  .   || . ..   . |  .  ||
dsliGkraened.riklkeldpellyvavfdGhaGsaaadfvhdkleki.lkrll...ekek...dleivlknafeeldkklkrylefsvaea.ellssG

TTAITVMI-SPTHIYWANCGDSRGFLCSDGKVKFATEDHKPYLAREKERIEKAGGSVIM-----QRVNGSLAVSRALGDFDYKRNNSIPakeqlvspEPE
|||  ...   |..  |. ||||  || .|| |  |.||.| |  ||||| .||||| .      .||| ||..|.|||.| ||   |         .||
ttatvsllrdGtelvlaslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryGvia........tPe

IDILPRDSENDEFLLLACDGIYDVMSNEEVMSYVRrqleLTANLEKICNDLIDLCLNKNSRDNMSVVLVVF
   |  | ..| ||.|  ||| .|....|.  .||    |  . |.  . | .  |.  | || ..|.| .
tkslkvdhaadsflvlitdgisfvvnsqelcdlvr....lchdpeeaahalteqalqygsednatavvvpl

subfamily_PPM1G_pd Subfamily PPM1G 4-115 4.4e-27 88.2 In-house 1-102 (473) alignment
Range on Protein: 4-115
Range on HMM: 1-102/473.0
FLEKPKTDKVTSSGEGYGIRYAVSAMQGWRMEMEDSHICDTDFIKNWSFFGVFDGHAGPKVSQYCSDHILRIMLDDlkasldecKSTEEpkERIKQAIYD
.|.|||..| .. .   ...|..||||||| ..||.| | ||. ...|.|.|.||| | .|..|...... .. ..        |. .|  . ...|. .
ylskpkvekesedesneelsygasamqGwrvsqEDahncitdldedtslfavyDGHGGkevakyvakklpdllkaq........kgyke..gdvekalee

GFLKLDSKIRED
 ||.||.|....
aflalDeklkae

subfamily_KAPP-like_pd Subfamily KAPP-like 32-289 2e-26 85.6 In-house 8-264 (266) alignment
Range on Protein: 32-289
Range on HMM: 8-264/266.0
WRMEMEDSHICDTDFIKN--------WSFFGVFDGHAGPKVSQYCSDHILRIMLDDLKAslDECKSTEEPKERIKQAIYDGFLKLDSKIREdptwangED
  .|||| ...   . |.         ..|.|||||||  ...  .. . ... . ||    . .   ...   .. . . | ..|.|...        .
cstemedvslaiypllkekklsncsnialfavfdGhaGkGaadaakklfpkelekllks..tkqddGGdniydqskllenafkevdaklkd.......fe

HSGTTAITVMI-S---PTHIYWANCGDSRGFLCSDGKVKFATEDHKPYLAREKERIEKAGGSVIM--QRVNGsLAVSRALGDFDYKRNNSIPAKEQLVSP
. |.||  ... |     ..  || |||  ||.   .  . . |||    .|| || . | ..     |.|| |||||||||   |. |   . |  ||.
yeGatatlalvwsdGqqrylqvanvGdssaflsrGneslelskdhkakdpeekqrikddGitlsdnqtrinG.lavsralGdhfikelniGlisepyvsn

epEIDILPRDSendeFLLLACDGIYDVMSNEEVMSYVRRQLELTANLEKICNDLIDLCLNK-NSRDNMSVVLV
  .| . | |.    ||..| ||..||.| .. .  |.   .  |  .|... |..  ..   ..||.||..|
..rilltpfdk....flivasdGlwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivv

subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 32-289 1.6e-24 79.2 In-house 7-274 (276) alignment
Range on Protein: 32-289
Range on HMM: 7-274/276.0
WRMEMEDSHICDTDFIK--------NWSFFGVFDGHAGPKVSQYCSDHILRIMLDDLKA---SLDECKSTEEPKERIKQAIYDGFLKLDSKIREDptwan
  .|||| ...   . .        | ..|.|||||||  ...  .. . ....  ||.   || . .   ...   .. . | | ..|.|...      
cstemedvslaiyplldekdlsncsnialfavfdGhaGkGaadaakklfpkelekllksgnysltkqddGGdniydqskllldlfkevdaklkdf.....

geDHSGTTAITVMI-SP---------THIYWANCGDSRGFLCSDGKVKFATEDHKPYLAREKERIEKAGGSVIM--QRVNGsLAVSRALGDFDYKRNNSI
  .. |.||  ... |           ..  || |||  ||.   .  . . |||     ||.|| . | ..     |.|| |||||||||   |. |  
..eyeGatatlalvwsdGeeqqqqqqrylqvanvGdssaflsrGneslelskdhkatdpeekqrikddGitlsdnqtrinG.lavsralGdhfikelniG

PAKEQLVSPepEIDILPRDSendeFLLLACDGIYDVMSNEEVMSYVRRQLELTANLEKICNDLIDLCLNK-NSRDNMSVVLV
 . |  ||.  .| . | |.    ||..| ||..||.| .. .  |.   .  |  .|... |..  ..   ..||.||..|
lisepyvsn..rilltpfdk....flivasdGlwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivv

subfamily_PDP_pd Subfamily PDP 90-281 4.7e-21 68.3 In-house 108-335 (398) alignment
Range on Protein: 90-281
Range on HMM: 108-335/398.0
TEEPKERIKQAIYDGFLKLDSKIREDPT---WA-N-----GEDHSGTTAITVMISPTHIYWANCGDSRGFLCS---DGKVKFA--TEDHKPYLAREKERI
 |   | .|.|.  .|||||. |...        .         ||..|....|..|... || ||.|  |..   .|...    ..|.    ..| |||
leaevekvkealkkaFlklDkdistealkklkekslreallvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRi

EKAG-----GSVIM-QRVNGSLAVSRALGDFDYKRNNSIPA----K--EQLVSP-----------EPEIDILpRDSENDEFLLLACDGIYDVMSNEEVMS
.|.       .||. .|. |.|. .|| ||. || .. .      |   . . |           |||.    . .||| ||.|| ||..|..|||||.|
kkeHPgeesktvirngRlLgeLqPlRAFGdvryKwseelqkkvlekaylkvlepkdyktPPYltaePevtsh.klrendkFLvlatDGLwdllsneevvs

YVRRQLELTANLEKICNDLIDLCLNKNSR
.| . |. ... |..  .  .| |.. ..
lVgehlakkkekepvkveeakltlkqvve

subfamily_PP2D1_pd Subfamily PP2D1 121-261 5.5e-20 64.5 In-house 172-309 (492) alignment
Range on Protein: 121-261
Range on HMM: 172-309/492.0
GEDHSGTTAITVMISPTHIYWANCGDSRGFLCSDGKVKFATEDHKPYLAREKERIEKAGGSVIM----QRVNGSLAVSRALGDFDYkrnnsiPAKEQLVS
| ...  .    .. .. .| || |. .  || .|| .  | .| |.  .|..|.||||..|       .||| | . | || .        |  .. | 
GlekesngsevhleelgvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGd......pkLkksvi

PEPEIDILPRDsENDEFLLLACDGIYDVMSNEEVMSYVRRQLELT
|||..   . | |.. ||.||  |...|.|.|||.| |.  |.. 
pePkttsvkld.eaaqflvlAsnGlWevlseeevlsLvkqtlaiy

PP2C_SIG_SM00331 52-289 2.9e-18 59.2 In-house 32-215 (217) alignment
Range on Protein: 52-289
Range on HMM: 32-215/217.0
FFGVFDGHAgpkvSQYCSDHILRIMLDDLKASLDECKSTEEPKERIKQAIYDGflkldskiredptwaNGEDHSGTTAITVMI--SPTHIYWANCGDSRG
.. |.||.     . ...  . . ... |. .|.| .....  .|. .|||.                ..|.....|..  ..  |  ... ||.|||| 
llvvaDgmG....kGlaAaaassqlrtalrellsegeelsqalkrlnraiyee...............keekgmfaTlllalydfssgklsyanaGdsrp

FLCSDGKVKFATEDhkpylarekeriekaggsvimqrvngslavsralgdfdykrnnsipAKEQLVS--PEPEIDILPRDSENDEFLLLACDGIYDVMSN
.|  ||| .. ..|                                               . ....  ||...||  .. | ...|||. ||. ...| 
yllrdgklveilkd..............................................vegaplGlepevsvdirelelekgdllllytDGltearse

-----EEVMSYVRRQL--ELTANLEKICNDLIDLCLNKNSRDNMSVVLV
     |...  ..  .  |. .  .|| ..|. |  ..| .|...||.|
kgfaeerleeiledlvdseaqelaqkiveellelakgsngeDdiTvvvv

PPM_PTC7_motif 235-284 2.2e-14 46.7 In-house 1-51 (51) alignment
Range on Protein: 235-284
Range on HMM: 1-51/51.0
LLACDGIYDVMSNEEVMSYVRRQLELT-ANLEKICNDLIDLCLNKNSRDNM
.||.||..||.|..|. . ||.||. .   .......|.| .|...| ||.
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni

subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 52-202 1.1e-13 44.3 In-house 22-185 (292) alignment
Range on Protein: 52-202
Range on HMM: 22-185/292.0
F-FGVFDGHA--GPKVSQYCSDHILRIMLddlkasldeckSTEEPKERIKQAIYDGFLKLDSKIREDptWANGEdHSGTTAITVMISPTH--IYWANCGD
|   |.|||   | ||.|.  |..   .|           ..  ..  . .|.  . |.. .|...    ..    |.|||..  . .    .. || ||
flaavldGhGvnGdkvaqlaedtlevell...........eltrqlqelsealllrildiaakldkl..tidar.esattavvcarvrddralilanvGd

SRGFLCS-----DGKVKFATEDHKPYLAREKERIEKAGGSVI-----------MQRV------NGSLAVSRALGDFDY
||  |       | ...  . ||||    |..|| .||| |              ||      .| ||.|||||||  
srallgrclggsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdfhl

PP2C_C Protein serine/threonine phosphatase 2C, C-terminal domain 285-360 1.4e-12 37.1 Pfam-A 1-76 (81) alignment
Range on Protein: 285-360
Range on HMM: 1-76/81.0
SVVLVVFPNAPKVSQEAIEKEKILQKEAQEKIEEKLKEMVKAANDPL-EVEENyILQQLIQEFPDNYCVPAKKSFIS
|..||.||.|||||.||..||. |.|  ....|| .... .   . | .| .. . .. | . |    . .|.| |.
siilvcfpgAPkvseeAvkkeaeLdkalesrveeiieksseeevpdllsvlkt.lasedipnLPPGGglasKrsvie

Subfamily Dicty-PPM1L-like 167-291 1.7e-12 39.8 In-house 178-303 (305) alignment
Range on Protein: 167-291
Range on HMM: 178-303/305.0
YLAREKERIEKAGGSVIMQ---RVNGSLAVSRALGDFDYKrnnsipakeQLVSPEPEIDILPRDSENDEFLLLACDGIYDVMSNEEVMSYVRRQLELTAN
.|  .. ||| ......     .||. | .||  || . |         .|| |...  .|     ||.||.|| ||...|.|...|   |.. |. .  
fldeiririeslqaalynygellvnrllkksrskGdknlk.........elviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkss

LE-------KICNDLIDLCLNKNSRDNMSVVLVVF
 .        | .    . ....|.||. .|.. .
qkkiewdfneisrviveeavkrgsgDnitlviikl

subfamily_TAB1_pd Subfamily TAB1 125-273 4.5e-11 35.1 In-house 129-297 (333) alignment
Range on Protein: 125-273
Range on HMM: 129-297/333.0
SGTTAITVMISPTHIYWANCGDSRGFLCS---DGKVKFATEDHKPYLAREKERIEKAGGS---VIMQRVNGSLAVSRALGDFDYKR----NNSI-PAKEQ
 ||||. ..|   ..| ||.||||  |.      |||    ||.     | .|... |     .  ... ||    |..||.  |     .. .  ||..
gGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkkgykdvdilssakge

LVSPEPEIDILPRDSENDEFLLLACDGIYDVMSN--------EE-VMSYVRRQLELTANLEKICNDLID
 |  ||.|       .   ||.|  ||.|  . .         | ..  |  .||  |.|... ....|
PviaePdiqgaypiddityflvlmSdGvyktLeevtgpetsnvenillevitelekqatlqdvAqavvd

subfamily_PPM1H_pd Subfamily PPM1H 185-262 4.6e-11 35.1 In-house 275-355 (404) alignment
Range on Protein: 185-262
Range on HMM: 275-355/404.0
QRVNGSLAVSRALGDFDYKRNNSIPAKEQLVSPEPEI---DILPRDSENDEFLLLACDGIYDVMSNEEVMSYVRRQLELTA
.|. . ..|.| ||| . |  ..      ..||.||.   |.   .|..|. |.|| ||..||.|||||   ||. |. . 
aRllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskve

PP2C_2 Protein phosphatase 2C 48-258 4.4e-10 32.2 Pfam-A 22-195 (212) alignment
Range on Protein: 48-258
Range on HMM: 22-195/212.0
KNWSFFGVFDGHAGPKVSQYCSDHILRIMLDDLKASLDECKST--EEPKERIKQAIYDGFLkldSKIREDPTWANGEDhSGTTAITVMISPTHIYWANCG
...... | ||.   | |.  .    ..... |...|.| . .  |.  ..|...|.        | ..  .... .|  .|| . ..|.|..|.....|
sdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvk...lkqeaeaqqeelkd.yatTlllavitpgeivffqiG

DSRG-FLCSDGKVKFATEDHKPYLAREKERIEKA--GGSVimqrvngslavsralgdfdykrnnsipakeqlvspepEIDILPrdSENDEFLLLACDGIY
|..  .  .||.|. ..|...   |.|  .. ..  ....                                     .| .|.   |  . |||  ||. 
Dgaivvrdrdgevqllgepdsgeyanettfltsedaeeel.....................................rirrlk..lepgdalllmTDGvs

DVMSNEE-VMSYVRRQL
| ...|| ........|
dslrkeepfrellaell

PP2C_2 Protein phosphatase 2C 48-258 4.4e-10 32.2 In-house 22-195 (212) alignment
Range on Protein: 48-258
Range on HMM: 22-195/212.0
KNWSFFGVFDGHAGPKVSQYCSDHILRIMLDDLKASLDECKST--EEPKERIKQAIYDGFLkldSKIREDPTWANGEDhSGTTAITVMISPTHIYWANCG
...... | ||.   | |.  .    ..... |...|.| . .  |.  ..|...|.        | ..  .... .|  .|| . ..|.|..|.....|
sdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvk...lkqeaeaqqeelkd.yatTlllavitpgeivffqiG

DSRG-FLCSDGKVKFATEDHKPYLAREKERIEKA--GGSVimqrvngslavsralgdfdykrnnsipakeqlvspepEIDILPrdSENDEFLLLACDGIY
|..  .  .||.|. ..|...   |.|  .. ..  ....                                     .| .|.   |  . |||  ||. 
Dgaivvrdrdgevqllgepdsgeyanettfltsedaeeel.....................................rirrlk..lepgdalllmTDGvs

DVMSNEE-VMSYVRRQL
| ...|| ........|
dslrkeepfrellaell

subfamily_Choan-PPM-1_pd Subfamily Choan-PPM-1 123-292 3.2e-09 28.4 In-house 133-316 (317) alignment
Range on Protein: 123-292
Range on HMM: 133-316/317.0
DHSGTTAITVMISPTHIYWANCGDS---------RGFLCSDG-KVKFATEDHKPYLAREKERIEKAGGSVIMQRVNGSLAVS-RALGDFDYKRNNSIPAK
|.  |....|..  ||.  || ||.          | .  || .|.. .  |.   . |..|.... .       .| ||.   || ... .   |.  |
dfGttavvavvvdethvvvanaGdaaalvllrdqaghedrdGlsvealsvrhtlrskaerarvaevlpgaahvtedgylaildealaayelqltkslGhk

---EQLVSPEPEIDILPRDSENDEFLLLACDGIYDVMSNEEVMSYVRRQLELTANLEKICNDLIDLCLNKNSRDNMSVVLVVFP
      |. .||.     | ..   ..   ||| | .....|.  | |        |..|.|  | .|...| |. . |....|
llkraGviadPevrsrvldvdevfavvvvsdGitdelkrldvldrvlraataleasevlcddaqdylldetsiddatavvlllp

subfamily_PP2D1_pd Subfamily PP2D1 32-103 2.3e-08 26.2 In-house 13-85 (492) alignment
Range on Protein: 32-103
Range on HMM: 13-85/492.0
WRMEMEDSHICDTDFIK--NWSFFGVFDGHAGPKVSQYCSDHILRIMLDDLKaSLDECKSTEEPKERIKQAIYD
|. .||| .    .|    | .|||..||. |    . .. .. ...|..|. ..||  |    ...|... . 
WKskmeDkrtlqdyfgndvnscFfgiyDGynGataAeiaakelhevlleele.kvdervslttavnlidnndlt

subfamily_PPM1H_pd Subfamily PPM1H 97-171 2.7e-08 26.0 In-house 136-208 (404) alignment
Range on Protein: 97-171
Range on HMM: 136-208/404.0
IKQAIYDGFLKLDSKIREDPTwaNGEDHSGTTAITVMISPTHIYWANCGDSRGFLCSDGKVKFATEDHKPYLARE
.. |. . ||..|..|... .  . ... | ||. ...    .| || ||||  |.  ....   .|. |   |.
viGalesaflemDeqiarere..ayrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftPeteRq

PPM_PTC7_SpoIIE_motif 230-289 6.6e-08 26.1 In-house 11-78 (81) alignment
Range on Protein: 230-289
Range on HMM: 11-78/81.0
NDEFLLLACDGIY-------DVMSNEEVMSYVRRQleL--TanLEKICNDLIDLCLNKN---SRDNMSVVLV
... |||..||..       .....||......|.     .  |....  |.| .|. .   ..|.......
pgdvllLyTDGltEardsdgelfgkeellrladra..egks..lqeladklvdevlengsgereDDitllvl

subfamily_PHLPP_pd Subfamily PHLPP 49-289 4.4e-07 22.0 In-house 26-243 (246) alignment
Range on Protein: 49-289
Range on HMM: 26-243/246.0
NWSFFGVFDGHAgpkvSQYCSDHILRIMLDDLKASLDECKSTeepKERIKQAiydgFLKLDSKIREDptwanGEdHSGTTAITVMISP--------THIY
. . .|.|||..    ... |  . |.| | ||  . . |.    .| .|.     .|.   |. |.     || . |..|. ..| .          . 
vealyGlfdGdr....neelssllqrlmkdvlkeevqkdkne...eeymknt....llvaqrklGea.....Ge.klgsaallilirhdkvdPaksfsLe

WANCGDSRGFLCSDGKvKFATEDHKPYLAREKERIEKAGGSVIM-QRVNGSLAVSRALGDFdykrnNSIPakeqLVSPEPEIDILPRdSENDEFLLLACD
 |. |     |. .|| |.  . .      | .|| .| . .   ...|| .. .| || .        |     | |.|..  ..  .|.||.|..  .
vAsvGtlqavliRngk.klrlsksyviekdelkrikeakaiitednkingviestrllGyt.....flfP....vvlPkphvrevlL.teqdellivGnk

GIYDVMSNEEVMSYVRRQLELTANLEKICndliDLCLNKNSRDNMSVVLV
 ...|.| .|. . ||.. .  .   |..    ||    . .|..||. |
alWevlsideaveavrkeedplvaAkklv....dlaqsygaadsvsvlvv

SpoIIE Stage II sporulation protein E (SpoIIE) 115-289 7.2e-07 21.2 Pfam-A 58-190 (193) alignment
Range on Protein: 115-289
Range on HMM: 58-190/193.0
DptwangedHSGTTAITVMI--SPTHIYWANCGDSRGFLCSD-GKVKFATEDHKPYLAREKEriekaggsvimqrvngslavsralgdfdykrnnsipak
.        . ..||. . .  |  ....||.|..  .|... |..|| .... . |  ..|                                      
e........erfatavlaeydpstgkleyanaGhpppllvrpdggtkfllvstglplGilpe......................................

eqlvspePEIDILPRDSENDEFLLLACDGIYDVMSNEEVMSYVRRQLELTA--N---LEKICNDLIDLCLN-K--NSRDNMSVVLV
        ...    . |... |||. ||... .. .. .    |.|.| |      ||.... |.. .|. .  . .| ......
.......adyeeaelqlepgdllllyTDGvtEardpdgelfgkerllallaeaegesleelldalveellelgsgeleDDitllvl

SpoIIE Stage II sporulation protein E (SpoIIE) 115-289 7.2e-07 21.2 In-house 58-190 (193) alignment
Range on Protein: 115-289
Range on HMM: 58-190/193.0
DptwangedHSGTTAITVMI--SPTHIYWANCGDSRGFLCSD-GKVKFATEDHKPYLAREKEriekaggsvimqrvngslavsralgdfdykrnnsipak
.        . ..||. . .  |  ....||.|..  .|... |..|| .... . |  ..|                                      
e........erfatavlaeydpstgkleyanaGhpppllvrpdggtkfllvstglplGilpe......................................

eqlvspePEIDILPRDSENDEFLLLACDGIYDVMSNEEVMSYVRRQLELTA--N---LEKICNDLIDLCLN-K--NSRDNMSVVLV
        ...    . |... |||. ||... .. .. .    |.|.| |      ||.... |.. .|. .  . .| ......
.......adyeeaelqlepgdllllyTDGvtEardpdgelfgkerllallaeaegesleelldalveellelgsgeleDDitllvl

Subfamily Dicty-PPM1L-like 23-78 2.4e-06 19.6 In-house 8-65 (305) alignment
Range on Protein: 23-78
Range on HMM: 8-65/305.0
RYAVSAMQGWRMEMEDSHICDTDFIK--NWSFFGVFDGHAGPKVSQYCSDHILRIMLD
.| . . .. |   || .       .  . |.||||||| | . ..|   ... |.  
kyelyvsansrkyqedrnkvkislessqelslfGvfdGhnGdiaaeyvkkklveivnk