Gene PPM1D-1 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1D
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP208_AA protein Get Run
AqueP208_AA_5-328 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1D_pd Subfamily PPM1D 6-328 9.5e-135 441.6 In-house 2-308 (309) alignment
Range on Protein: 6-328
Range on HMM: 2-308/309.0
ISAMAETNSGGRPYMEDYIAVYLSPKESLLsnplMREQAFVGVFDGHGGKEAAKYARDHLWSVVQNQPKFLTQDSQSVREAISNAYLQLHNTMQESRASW
.|...|...|||.||||..|..|...||..    ..|.|||.||||||||||||.||.|||||...| |||......|.|||..|.|..|..|......|
lsvtseadqGgrkymeDvvaivleeeesae....elevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeW

APNKYGDLCTAGTTASTVIFRNNHIYVANVGDSTGIMGVRNPhfgepEEPLIIPKVLIKDHKPEDPEEQENTRRLGGEIALSlRGVMRVVWERERVESNE
...| |.|.|||||||.||.|....|||.||||. ..||..|     .|. ...|.|.||||||.|||.|....||||.| . .||.||||.|.|.|.|.
pktksgllstaGttasvviirreklyvahvGDsaivlgvkep.....kekklrakeltkdHkPespeekerieelGGevaak.sGvkRvvWkRprlehng

KKVIDRWPFLGVTRSQGDIWSYSAQSGEYTVSPVPYVCDFPIDLNVQRFIVLASDGLWNVMSPLEVVNFISDTDSKGSCGNSSNsdtnvqRDVVSALIKE
..|||..||| |.||.||.|||.|.|||..|||.|.|... .| | ..||.|||||||||..| ..|........|... ....      |.|..||.||
ptvideiPFLavaRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqs......rsvakalvke

ALGRWSHMKLQADNIAVLIVYLS
||.||...||.|||..|..|.|.
alqrwrskklraDnvsvivvile

0034914 PP2C-like 6-328 9.1e-49 158.9 In-house 21-291 (295) alignment
Range on Protein: 6-328
Range on HMM: 21-291/295.0
ISAMAETNSGGRPYMEDYIAVYLspkesllsN--PLMREQAFVGVFDGHGGKEAAKYARDHLWSVVQNQ----PKFLTQDSQSVREAISNAYLQLHNTMQ
... . .. | |...||.. |.|        |  .|.......|||||||| .||..|...|.. . ..      .|| .. ...||. .|.|.... . 
lrvgvasdqGrrksneDavlvvl........nllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeell

ESRASwapnkYGDLCTAGTTASTVIFRNNHIYVANVGDSTGIMGvRNPhfgepeepliIPKVLIKDHKPEDPEEQENTRRLGGEIALSLRGvmrvvwere
|   .     . .| . ||||.....|.|..||||||||  ..  ||            .. | .|||| ...|.|  ...|| .  . .          
elall.....rpelagsGtTavvalirgnklyvanvGDSravll.rng..........elvqltvdhkpvnelererilsaggavshgrvn.........

rvesnekkvidrwPFLGVTRSQGDIWSY---SAQSGEYTVSPVPYVCDFPIDLNVQRFIVLASDGLWNVMSPLEVVNFISD----TDSkgscgnssnsdt
             ..| |||. || . .   |    |. ||..|.|. ....|.   |..|||||||.|.|. |.|.....    ...            
.............gvlavtRalGdfdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgld............

nvQRDVVSALIKEALGRWSHmklqaDNIAVLIVYLS
    ... .|...|| |.|.     ||| |..|.|.
..leeaaeeLvdlAlargsr.....DNiTvvvvrln

PP2Cc_SM00332 11-325 9.9e-49 159.2 In-house 15-274 (274) alignment
Range on Protein: 11-325
Range on HMM: 15-274/274.0
ETNSGGRPYMEDYIAVYLSPKesllsnpLMREQAFVGVFDGHGGKEAAKYARDHLWSVVQNQPKFLTQD-SQSVREAISNAYLQLHNTMQESRASWAPNK
 .. | |  ||| ..|... .          . .|.||||||||.|.||.....|.. .....|. ... ...| ||...|.|.... . |.  |. ...
ssmqgwrksmeDahvvvvdlv.......eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskelen

ygdlCTAGTTASTVIFRNNHIYVANVGDSTGIMGVRNPhfgepeepliiPKVLIKDHKPEDPEEQENTRRLGGeialslrgvmrvvwererveS---Nek
     ..|.||..........||||||||  ...  .             . | .||||||..| .  .. ||                    .   .  
....alsGstavvallkkedlyvanvGDSravlcrngk...........avqlsvdhkpedederkRikkagg....................vvekg..

KVIDRwpfLGVTRSQGDIWSYSAQ-SGEYTVSPVPYVCDFPIdLNVQRFIVLASDGLWNVMSPLEVVNFISDTDSKGscgnSSNSDTNVQRDVVSALIKE
.| .    | |.|. || .   .. . |  ... | |    .  .  .|..|||||||.|.|. |||... .. .||    . |. .... ... ..|. 
rvngg...lavsrafGdhflkknkklkepyitaepdvkvvtl.tsedeflilaSDGlwdvlsnqevvdivrkllakg....ktndpqeaaelldeeairr

algrwshmKLQADNIAVLIV
        .  .||| |..|
........ggseDniTvvvv

PPM_PTC7 38-290 3.3e-48 157.4 In-house 29-238 (259) alignment
Range on Protein: 38-290
Range on HMM: 29-238/259.0
PLMREQAFVGVFDGHGGKEAAKYARDHLWSVVQNQPKFLTQDsqSVREAISNAYLQLHNTMQESRaswaP--NkyGDLCTAGTTASTVIFRNNHIYVANV
    . ||..||||||| ||||||| ||. ...... | . .   . .|.....|.|.  .   .    .  |      | |.||..........|||||
sgkdsvaffavfdghggreaakyarehleeilkerksfeele..klekalrksflaldtdeelks....sean..tepstsGstAvvalitgsklyvAnv

GDSTGIMGVRNPHFgepeepliipKVLIKDHKPEDPEEQENTRRLGGEIALSlrGVMRVVWErervesnekkvidrwpfLGVTRSQGDIWSYSAQSGEYT
|||  ... ..  .          | | .||||....| |  ...||..     |. ||..                  | |.|. || .... ...|  
GDSravLcrsgnav..........kqltedHkpsnedEreRiegaggsvsnv..gngrvngv.................lavsRafGdfelkpketeeql

VSPVPYVCDFPIDLNvQRFIVLASDGLWNVMSPLEVVNFISDTDSKGscgnssnS
||. |...  .|| . . |..|||||||.|.|. |.| .. .. ||.       .
vsaePdisstkidee.defliLasdGlwdvvsdqeavdlvrselskk.......d

PP2C Protein phosphatase 2C 11-298 1.4e-47 155.4 Pfam-A 6-238 (255) alignment
Range on Protein: 11-298
Range on HMM: 6-238/255.0
ETNSGGRPYMEDYIAVYLSPKESllsnPLMREQAFVGVFDGHGGKEAAKYARDHLWSVVQNQPKFLTQDsqSVREAISNAYLQlHNTMQESR--ASwapn
....| |  ||| .. . . ..|        . ||..||||||| ||||||| ||. ....|..||. .   |..|.....|. .  ..  .  |.    
selqgarksmedahialknleks....sgkssvaffavfdghggreaakyarehleeilkeqksflele..kvekalrksfla.dtdeelksskan....

kYgDLCTAGTTASTVIFRNNHIYVANVGDSTGIMGVRNPHFgepeepliipKVLIKDHKPEDPEEQENTRRLGGEIALslrgVMRVVWErervesnekkv
      . |.||.....|....||||||||  ... ..  .          | | .||||.|..| |  ...||..      . ||..            
.t.epsksGstavvalirgkklyvAnvGDSravLcrkdnak..........keltedHkpsdedEreRIeeaggsvsn....ngrvngs...........

idrwpfLGVTRSQGDIWSYSAQsgEYTVSPVPYVCDFPIDLNvQRFIVLASDGLWNVMSPLEVVNFISDTDSKGScgnssnsdtnVQRDV
      | |.|. || .... .  |. ||. |.|. .... .   |..|||||||.|.|. |.| .. .. ||..            ...
......LavsRalGdfelkpke..eqlvsaePdvtsvkltee.defliLasdGlwdvlsdqeavdlvrselskkk..........spmea

PP2C Protein phosphatase 2C 11-298 1.4e-47 155.4 In-house 6-238 (255) alignment
Range on Protein: 11-298
Range on HMM: 6-238/255.0
ETNSGGRPYMEDYIAVYLSPKESllsnPLMREQAFVGVFDGHGGKEAAKYARDHLWSVVQNQPKFLTQDsqSVREAISNAYLQlHNTMQESR--ASwapn
....| |  ||| .. . . ..|        . ||..||||||| ||||||| ||. ....|..||. .   |..|.....|. .  ..  .  |.    
selqgarksmedahialknleks....sgkssvaffavfdghggreaakyarehleeilkeqksflele..kvekalrksfla.dtdeelksskan....

kYgDLCTAGTTASTVIFRNNHIYVANVGDSTGIMGVRNPHFgepeepliipKVLIKDHKPEDPEEQENTRRLGGEIALslrgVMRVVWErervesnekkv
      . |.||.....|....||||||||  ... ..  .          | | .||||.|..| |  ...||..      . ||..            
.t.epsksGstavvalirgkklyvAnvGDSravLcrkdnak..........keltedHkpsdedEreRIeeaggsvsn....ngrvngs...........

idrwpfLGVTRSQGDIWSYSAQsgEYTVSPVPYVCDFPIDLNvQRFIVLASDGLWNVMSPLEVVNFISDTDSKGScgnssnsdtnVQRDV
      | |.|. || .... .  |. ||. |.|. .... .   |..|||||||.|.|. |.| .. .. ||..            ...
......LavsRalGdfelkpke..eqlvsaePdvtsvkltee.defliLasdGlwdvlsdqeavdlvrselskkk..........spmea

subfamily_PPM1A_pd Subfamily PPM1A 8-327 7.1e-39 126.8 In-house 14-280 (282) alignment
Range on Protein: 8-327
Range on HMM: 14-280/282.0
AMAETNSGGRPYMEDYIAVYLSpkesllsNPLMREQAFVGVFDGHGGKEAAKYARDHLWSVVQNQPKF-----LTQDSQSVREAISNAYLQLHNTMQESR
.  ....| |  |||  .|  |        . .....|  |||||.|.|.|||. .|| . . .. ..       .....|.||.....|.|.....|. 
ygvssmqgwrvemEDahtvvas.......lgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairels

ASWAPNkygDLCtaGTTASTVIFRNNHIYVANVGDSTGIMgVRNPhfgepeepliIPKVLIKDHKPEDPEEQENTRRLGGEIAlslrgvmrvvW-----E
..   .   | .  |.|| ||. ...|...||.||| ... .||             . | .||||..|.|..  .  ||..                  
tdlkta...dks..GsTavtvlvsekhliianlGDsRavl.crng..........kaaflteDHkpsrpkEkkRieqAGGsvv..........vsRvnGa

rervesnekkvidrwpfLGVTRSQGDIWSYS---AQSGEYTVSPVPYVCDFPIDLNVQrFIVLASDGLWNVMSPLEVVNFISDTDSKGSCGNSSnsdtnv
                 | |.|. ||    .    .. |  ||..|.|  . .. . . |.|||.||.| |.|  |||... .. ....  ..       
.................LAvsRalGDyeykeeeekkaeeqlvsaepevtsierseedd.flvlacDGiwDvlsdeevvelvrkrlevadeleev......

qrdvVSALIKEALGRWSHmklqaDNIAVLIVYL
    ..||...|| . |.     ||..||.| .
....akalvdkalekgsr.....DNlsvlvvlf

0049733 PP2C-like 7-327 4.4e-35 114.2 In-house 4-233 (235) alignment
Range on Protein: 7-327
Range on HMM: 4-233/235.0
SAMAETNSGG-RPYMEDYIAVylspkesllsnplmrEQAFVGVFDGHGGKEAAKYARDHLWSVVQNQPKFltQDSQSVREAISNAYLQLHNTMQESRASW
|. | .  |  |...||...|               ......|.||||| .|...|...|....... .   ... ...||. .|.|.... . |   ..
svgaasdigrvrkvneDavlv...............glllfavaDGhgghaagevasellvetllellle..lllldleealrkaflaaneallelalas

ApnkygDLCTAGTTASTVIFRNNHIYVANVGDSTGIMGvRNPHfgepeepliiPKVLIKDHKPEDPEEQENTRRLGGEIalslrgvmrvvwerervesne
      .| . ||||..........||||||||  ..  |. .             | .||.| ...|..  ...|| .                     
p.....elagmgtTavvalldggklyvanvGDsrayll.rdgk..........lvqltedhspvnelerqriitaggav.....................

kkviDRWPFLGVTRSQGDIWSYsaqsgeytvspvPYVCdfPIDLNVQRFIVLASDGLWNVMSPLEVVNFISDTDSkgscgnssnsdtnvqRDVVSALIKE
       . | .||. || .              |.|.   ..|. . |..|||||||.|.|. |.|......|                ......|...
....rvpgrlaltralGdlllk............pdvt..vlelepgdflllasDGlwdvlsdeeivdllrsldl...............eeaaerlvel

ALGRWSHmklqaDNIAVLIVYL
|| |...     ||| |..|.|
alarggr.....DNiTvvvvrl

subfamily_PPM1E_pd Subfamily PPM1E 15-328 1.7e-31 102.4 In-house 13-263 (265) alignment
Range on Protein: 15-328
Range on HMM: 13-263/265.0
GGRPYMEDYIAVYLSpKESLLSNPLMREQAFVGVFDGHGGKEAAKYARDHLWSVVQNQPKFLTQDSqsvreaisnayLQLHNTMQESRASWAPNKYGDLC
. |  |||   .. .  ..|.    ..|.|| .||||||| ||||||  ||.... .|.|. ..              .|......   .       .  
nkrrkmEDrhvaled.lnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa...........ealkeafkltDerflqkaerekl

TAGTTASTVIFRNNHIYVANVGDSTGIMgVRNPHFGEpeepliipkvLIKDHKPEDPEEQENTRRLGGEIALSlrGVMRVvwerervesNEKkvidrwpf
..|.|| .|. .....||| .||| ... ||. .. .          |.| ||||...|..    .|| .     |..||         |          
ksGstavvvliekdqlyvaWlGDsqall.vrkgeavq..........lmkpHkPeredEkkRieeagGlvvvi..gawRv.........nGv........

LGVTRSQGDiwsysaQSGEYTVSPVPYVCDFPIDlNVQRFIVLASDGLWNVMSPLEVVNFISDTDSKgscgnssnsDTNVQRDVVSALIKEALGRWSHmk
| |.|. ||      .. .  ||  . |.....| . . ...||.||||.|. . |||. ...  ..         ... . .|   |...|  . |.  
LsvsRaiGD......vklkpyvsgeadvaeveld.gseeylilacDGlwDvvneeevvklveeflad.........gaedlsevakllveaakeagss..

lqaDNIAVLIVYLS
   |||.|..|.|.
...Dnitvvvvfld

subfamily_PPM1G2_pd Subfamily PPM1G2 32-327 6.4e-31 100.3 In-house 41-286 (287) alignment
Range on Protein: 32-327
Range on HMM: 41-286/287.0
ESLLSNPLMREQAFVGVFDGHGGKEAAKYARDHLWSVVQNQPKFLtqdSQSVREAISNAYLQLHNTMQESraswapNKYGDlCTAGTTASTVIFRNNHIY
. ||...  .. |...|||||||...||||  .| ........|    ........ .|.|.. . ...       .|  |  .||.|| .|. .....|
nelleksddkslalfavfDGhGGakvakyagkklikkiakkksfk...egaleqilkdafletDeellkd......eklkd.esaGstavvvlikeekly

VANVGDSTGIMGVRnphfGEpEepliipKVLIKDHKPEDPEEQENTRRLGGEIALSlRGVMRVVWERERVESNEKKVIDrwpflgvtrsqgdiwsysAQS
|||.|||  .. ..    |.        | |  ||||.. .|..     || ..|  |    .   |   . . ||                      ..
vanaGDsravlssk....gn.v......kalsfDhkPqeesekkriiaagGfveln.rvngnLalsralgDfefkknvk..................kkp

GEYTVSPVPYVCDFPIDlNVQRFIVLASDGLWNVMSPLEVVNFISDTDSKGscgnsSNSDtnvqrDVVSALIKEALGRWSH-MKLQADNIAVLIVYL
 |  |  || |    .| . . |.||| ||.|.|..  |||...    ..|      . |     .... |....| . |.   . .||..|.|| |
eeqivtavPDvlvkkld.eddeflvLaCDGiWDvltnkevvdlvrerlvsg.....akld.....eiieelldkclapdssntgvGcDnmtvvivvl

subfamily_ILKAP_pd Subfamily ILKAP 8-327 1.1e-30 99.8 In-house 7-292 (293) alignment
Range on Protein: 8-327
Range on HMM: 7-292/293.0
AMAETNSGGRPYMEDYIAVYLSPK-ESLLSNPLMREQAFVGVFDGHGGKEAAKYARDHLWSVVQNQ-PKFL-TQDSQSVREAISNAYLQLHNTMQESRAS
..     | |  |.|   .  . . .. |.. |.   .. .|||||.|. |...| ..|  .. .. ||   ..  .... .. ... .  . . .  ..
gayaerkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefLklask

WAPnKYGDlctaGTTASTVIFRNNHIYVANVGDSTGIMGVRNPHFGEpeeplIIPKVLIKDHKPEdpeeqentrrlggeialslrgvmrVVWERERVESN
  | .. |    |.|| .|.  .| .||||.|||  ..  ....  .     |.  || |||.|                            ||.|..  
akP.vWkd....GstatvvlvldnvlyvanlGdskavlvrkkeegdk.....iasvvLtkdhtpv........................kyeerkriqka

EKKVIDR--WPFLGVTRSQGDIwSYSaqsgEYTVSPVPYVCDFPIDLNvQRFIVLASDGLWNVMSPLEVVNFISDTDSKG-SCGNSSNSDTNVQRDVVSA
  .| |      |.|.|| ||   .     .  |. .| |    .. |  .|.||| ||||.|.|  |||.||...  .  .  . ...... ...|   
GgvvrdgrvlGvlevsrsiGdg.rfk....rlGvistPdvkkceLten.dlfvvlaCdGLwkvfsadevvkfilkvledeeddrkikeeekkskeevrfe

LIKEALGRWSHMKLQADNIAVLIVYL
.. . |   .  .  .||..||.| .
vacnrlaseavkrgssdnvtvllvki

subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 14-280 1.3e-25 83.1 In-house 14-225 (255) alignment
Range on Protein: 14-280
Range on HMM: 14-225/255.0
SGGRPYMEDYIAVYLSPKESllsnplmREQAFVGVFDGHGGKEAAKYARDHLWSVVQNqpkFLTQDSQSVREAISNAYLQLHNTMqesraswapNKYGdl
 | || ||| ...| | ..         .. .. .||||||..|||.| ..|  ....   .|   . .  ... .|| ...  .         ....  
iGrrptmedelviyGsfrdk.......sdedyyalfdGhgGraaakfaseelykilae...lldlnnanPvkslkkaykeistqi.........serp..

CTAGTTASTVIFRNNHIYVANVGDSTGIMGvrnphfgepeEPLIIPKVLIKDHKPEDPEEQENTRRLGGEIALSlrgvmrvvwerervesnekKVIDR-W
   |||| .|.. ....|.||||||  ...          .   . | |  |||| ...|..  ..||| .  .                   .|  |  
kfiGttaasvliiedkvyianvGdsrvvlc..........qkdgtakrlsldhkPseeseekriselGGtvvst...................vvtsrvn

PFLGVTRSQGDIWSysaqsgEYTVSPVPYVCDFPIDLNVQRFIVLASDGLWNVMSPLEVVNFISDTDS
  | |.|. ||..       |  | | |.. .     . ..|..|| ||.|...|  | |. . .  .
GtlavsralGdsfl......ePfvvpdPdlsqsleiskkdkflilacdGiwdlisdeeaveivagisd

PPM_PTC7_SpoIIE 38-281 1.8e-22 73.3 In-house 29-211 (230) alignment
Range on Protein: 38-281
Range on HMM: 29-211/230.0
PLMREQAFVGVFDGHGGKEaaKYARDHLWSVVQNQPkFLTQDsqSVREAISNAYLQLHNTMQESraswapnkygdLCTAGTTASTVIFRNNH--IYVANV
.  |  ..||..||||| .  ..|. .|.......  | . .   . |......|.|.  ....             . |.||. .......  .||||.
sggrlalvvgdvdGhGgra..alamgllrtalrela.fagle..kpeeilrrlnlalaadlede...........psssgaTavvalidpstgklyvana

GDSTGIMGVRNPHfgepeepliipkvlikdhkpedpeeqENTRRlGGEIALS--L-RGvmRVVWErervesnekkvidrwpfLGVTRSQGDIWSYSaqsG
|||  ..   ...                          | .|  ..  ..|  .  |  ||...                 | |... ||.. .     
Gdsppllvrddgg..........................ereri.vagglpslGilpg..rvfgv.................lavslapGdlllly...t

EYTVSPVPYvCDFPIDLNVQRFIVLASDGLWNVMSPLEVVNFISDTDSK
.  |.. |.  .  .. ....|..|||||||.|.|| |.| .. |. .|
DGvveaepd.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelek

subfamily_PPM1L_pd Subfamily PPM1L 15-285 4.4e-22 71.6 In-house 14-242 (269) alignment
Range on Protein: 15-285
Range on HMM: 14-242/269.0
GGRPYMEDYIAVYLSPKESllsnplmREQAFVGVFDGHGGKEAAKYARDHLWSVVQNQPKFLTQDSqSVREAISNAYLQLHNTMQESRASWAPNKYgDLC
| || ||| . .    |..        .. |..|||||||. ||..|.| |   ..|. . | .|     | |. . |  .. .   .      |     
Grrprmedrfeieediknk.......tgesffavfdGhGGefaaefakdvlvkaiknklieldadk.entepinfsklltdeilsvdekllekakr.aed

TAGTTASTVIFRNNHIYVANVGDSTGIMGVRNphfGEpeeplIIPkvLIKDHKPEDPEEQENTRRLGGEIAlsLRGVMRVvwerervESnekkvidrwpF
.|||||   . ..... ||||||| |..  ..   |.      ||  |  ||||....|.   .. || ||  .||| ||       .            
iaGttalialvqesdlivanvGdsrGvlydkr...Gk.....aip..lsfdhkpqqvkerkrikkaGGfia..frGvwrv.......aG..........v

LGVTRSQGDiwsYSAQSGEyTVSPVPYVCDFPIDLNVQRFIVLASDGLWNVMSPLEVVNFISDTDSKGSCG
| ..|. ||   |  .  .  | . | .  | .|    .|..|||||||. .|  | |.|| .  ..   |
latsralGd...yplkdkn.lviadpdiltfdlddhkpeflilasdGlwdtfsneeavrfikerlkepdfG

subfamily_PPM1K_pd Subfamily PPM1K 40-278 4.1e-20 65.0 In-house 28-228 (263) alignment
Range on Protein: 40-278
Range on HMM: 28-228/263.0
MREQAFVGVFDGHGGKEAAKYARDHLWSVVQnqpkFLTQDSQSVREAISNAYLQLHNTMQESRASWAPNKygDLCTAGTTASTVIFRN-NHIYVANVGDS
  |  .|.|||||.|  ||... |.|  ...    .| .  . ... . ||...|.. ..       ...  .| ..||||. ...|. ... .|..|||
dpellyvavfdGhaGsaaadfvhdklekilk....rllekekdleivlknafeeldkklkrylefsvaea..ellssGttatvsllrdGtelvlaslGds

TGIMgVRNphfGEpeepliiPKVLIKDHKPEDPEEQENTRRLGGEIALSLRGVMRVvwerervESNekkvidrwpfLGVTRSQGDIwsysaQSGEYTVSP
  |.  ||   |.       .| | .||.||  ||.|  .. || .. .  | ..|       ..           | .||| ||.     .  .| |  
rail.crn...Gk.......akkltrdhdPeleeekerikaagGsvewnslgkplv.......ngr..........lamtrslGdl.....dlkryGvia

VPYVCDFPIDLNVQRFIVLASDGLWNVMSPLEVVNFISDT
 |    . .| . . |.|| .||. .|..  |. ....  
tPetkslkvdhaadsflvlitdgisfvvnsqelcdlvrlc

subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 45-200 4.7e-16 52.2 In-house 22-169 (292) alignment
Range on Protein: 45-200
Range on HMM: 22-169/292.0
F-VGVFDGHG--GKEAAKYARDHLWSVVQNqpkfLTQDSQSVREAISNAYLQLHNTMQESRASwapnkygDLCTAGTTASTVIFRNN-HIYVANVGDSTG
|   |.||||  |.. |..| |.|   . .    ||.. | . ||. .  |..   .... .            |.|..   . |..  ...||||||  
flaavldGhGvnGdkvaqlaedtlevelle....ltrqlqelsealllrildiaakldkltid.......aresattavvcarvrddralilanvGdsra

IMGVRnphFGEPEEPLiIPkvLIKDHKPEDPEEQENTRRLGGEIA------LSLRGVMRVvWERER
..|     .|  .  | ||  | .|||||||.|..  .| || .          ||  || | | .
llgrc...lggsdyel.iP..lsrdhkPedPderarilraGGrveptrvrgwgfrGtarv.wrrrq

subfamily_PPM1G_pd Subfamily PPM1G 41-99 5e-10 32.0 In-house 45-100 (473) alignment
Range on Protein: 41-99
Range on HMM: 45-100/473.0
REQAFVGVFDGHGGKEAAKYARDHLWSVVQNQPKFltqDSQSVREAISNAYLQLHNTMQ
 . .. .|.||||||| |||  ..|  ....|  .   .   |..|...|.|.| ....
edtslfavyDGHGGkevakyvakklpdllkaqkgy...kegdvekaleeaflalDeklk

subfamily_KAPP-like_pd Subfamily KAPP-like 18-178 9.8e-10 30.9 In-house 10-155 (266) alignment
Range on Protein: 18-178
Range on HMM: 10-155/266.0
PYMED-YIAVYLSPKESLLSNplMREQAFVGVFDGHGGKEAAKYARDHLWSVVQNQPKFLTQDsqSVREAISNAYLQLHNTMQESRASWAPNKYgDLCTA
  ||| ..|.|   ||  |||    . |. .||||| || ||. |.. .  ..... |   ||     . | .    |.|...|  |     .| . .||
temedvslaiypllkekklsn..csnialfavfdGhaGkGaadaakklfpkelekllkstkqd..dGGdniydqskllenafkevdaklkdfey.eGata

GTTASTVIFRNNHIYVANVGDSTGIMGVRNphfgepeEPLiipkVLIKDHKPEDPEEQENTR
  .      .  .. |||||||. ..   |       | |     | |||| .||||.   .
tlalvwsdGqqrylqvanvGdssaflsrGn.......esl....elskdhkakdpeekqrik

subfamily_PPM1G_pd Subfamily PPM1G 116-189 2.1e-09 29.9 In-house 296-358 (473) alignment
Range on Protein: 116-189
Range on HMM: 296-358/473.0
AGTTASTVIFRNNHIYVANVGDSTGIMGVRnphfgepeeplIIPKVLIKDHKPEDPEEQENTRRLGGEIALSLR
.||||  .. ......|||.|||  ..                   |  ||||||..|.|  .. ||..   .|
sGttAvvaLlkekklivAnaGDsRcvlsrn...........GkAldlslDHkPeDevEleRiekAGGkvdedgR

Subfamily Dicty-PPM1L-like 41-138 5.5e-09 28.3 In-house 35-137 (305) alignment
Range on Protein: 41-138
Range on HMM: 35-137/305.0
REQAFVGVFDGHGGKEAAKYARDHLWSVVQNQPKFLT--------QDSQSVREAISNAYLQLHNTMQESraSWAPNKYGDLCTAGtTASTVIFRNNHIYV
.|. . ||||||.|. ||.|.. .|  .| .  |             ...  |||..|.|.  . . .|  . . || .     | ....||. .. . |
qelslfGvfdGhnGdiaaeyvkkklveivnkyvkenkvGysaknlnvddlpleaiksaslstdksslds..aesdnkkaGttlng.ssasvilerertiv

ANVGDS
.. .|.
stasdt

subfamily_PDP_pd Subfamily PDP 75-148 2.2e-08 26.6 In-house 107-184 (398) alignment
Range on Protein: 75-148
Range on HMM: 107-184/398.0
FLTQDSQSVREAISNAYLQLHNTMQESRASWAPNKYG----DLCTAGTTASTVIFRNNHIYVANVGDSTGIMGVRNPH
 |  . ..|.||...|.|.| . ...   . ...|      .  ..|..| ..  ......|||.||.  ..||....
lleaevekvkealkkaFlklDkdistealkklkekslreallvalsGacallaliegtelhvAntGDcravlgvqeee

subfamily_PPM1G_pd Subfamily PPM1G 252-306 9.6e-08 24.4 In-house 402-448 (473) alignment
Range on Protein: 252-306
Range on HMM: 402-448/473.0
QRFIVLASDGLWNVMSPLEVVNFISDTDSKGSCGnssnsdtnVQRDVVSALIKEA
. |.|||.||.||||.  |||.|. .  .||.          |  ..| .|. ..
deFlvlAcDGiWnvmesqevvdfvraklkkgees........vlseiveeLlDac

PPM_PTC7_motif 256-278 1.1e-07 25.2 In-house 1-23 (51) alignment
Range on Protein: 256-278
Range on HMM: 1-23/51.0
VLASDGLWNVMSPLEVVNFISDT
.|||||||.|.|. |.|... |.
iLAsDGLWDvlsdqeavdlvrdq

subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 18-178 1.9e-07 23.2 In-house 9-165 (276) alignment
Range on Protein: 18-178
Range on HMM: 9-165/276.0
PYMED-YIAVYLSPKESLLSNplMREQAFVGVFDGHGGKEAAKYARDHLWSVVQNQPKF----LTQDSQSVrEAISNAYLQLHNTMQESRASWAPNKYGD
  ||| ..|.|   .|  |||    . |. .||||| || ||. |.. .  ...   |     ||.. .   . | .    | . ..|  |     .|  
temedvslaiyplldekdlsn..csnialfavfdGhaGkGaadaakklfpkelekllksgnysltkqddGG.dniydqskllldlfkevdaklkdfeyeG

lCTAGTtasTVIF---------RNNHIYVANVGDSTGIMGVRNphfgepeEPLiipkVLIKDHKPEDPEEQENTR
 .||     ....         .. .. |||||||. ..   |       | |     | |||| .||||..  .
.atatl...alvwsdGeeqqqqqqrylqvanvGdssaflsrGn.......esl....elskdhkatdpeekqrik

subfamily_PDP_pd Subfamily PDP 251-299 2.8e-07 23.0 In-house 284-333 (398) alignment
Range on Protein: 251-299
Range on HMM: 284-333/398.0
VQRFIVLASDGLWNVMSPLEVVNFISDTDSKGSCGNSS-NSDTNVQRDVV
 ..|.|||.||||...|. |||. ...  .|    ..   ......   |
ndkFLvlatDGLwdllsneevvslVgehlakkkekepvkveeakltlkqv

subfamily_PP2D1_pd Subfamily PP2D1 230-278 2.1e-06 19.7 In-house 258-305 (492) alignment
Range on Protein: 230-278
Range on HMM: 258-305/492.0
QSGEYTVSPVPYVCDFPIDLNVQrFIVLASDGLWNVMSPLEVVNFISDT
.  . .| | |..   ..| . | |.|||| |||.|.|  ||.. . .|
pkLkksvipePkttsvkldeaaq.flvlAsnGlWevlseeevlsLvkqt

subfamily_TAB1_pd Subfamily TAB1 116-184 3e-06 19.2 In-house 129-189 (333) alignment
Range on Protein: 116-184
Range on HMM: 129-189/333.0
AGTTASTVIFRNNHIYVANVGDSTGIMGVRNPhfgepEEPLiipKVLIKDHKPEDPEEQENTRRLGGEI
 ||||  ..  ||..||||||||  ..  |..     .|     | | .||. . ..| .  ..|| .|
gGttAvvalifnnkLyVaNvGdsrAllvkrke.....sekv...kqLsvdHttdNedEllRlkdLGldi

PP2C_SIG_SM00331 43-140 8e-06 18.6 In-house 30-112 (217) alignment
Range on Protein: 43-140
Range on HMM: 30-112/217.0
QAFVGVFDGHG-GKEAAKYARDhLWSVVQNQPKFLTQDSQSVREAISNAYLQlhntmqesraswapnkyGDLCTAGTTASTVI--FRNNHIYVANVGDST
. .. |.||.| |..|| ...  | ...... .  .  || ...... .| .                  . .  ..|.   .  |.......||.||| 
rlllvvaDgmGkGlaAaaassq.lrtalrellsegeelsqalkrlnraiyee.................keekgmfaTlllalydfssgklsyanaGdsr

G
 
p