Gene PPM1D-1 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1D
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP208_AA protein Get Run
AqueP208_AA_5-328 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1D_pd Subfamily PPM1D 6-328 9.5e-135 441.6 In-house 2-308 (309) alignment 
Range on Protein: 6-328
Range on HMM: 2-308/309.0
ISAMAETNSGGRPYMEDYIAVYLSPKESLLsnplMREQAFVGVFDGHGGKEAAKYARDHLWSVVQNQPKFLTQDSQSVREAISNAYLQLHNTMQESRASW
.|...|...|||.||||..|..|...||..    ..|.|||.||||||||||||.||.|||||...| |||......|.|||..|.|..|..|......|
lsvtseadqGgrkymeDvvaivleeeesae....elevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeW

APNKYGDLCTAGTTASTVIFRNNHIYVANVGDSTGIMGVRNPhfgepEEPLIIPKVLIKDHKPEDPEEQENTRRLGGEIALSlRGVMRVVWERERVESNE
...| |.|.|||||||.||.|....|||.||||. ..||..|     .|. ...|.|.||||||.|||.|....||||.| . .||.||||.|.|.|.|.
pktksgllstaGttasvviirreklyvahvGDsaivlgvkep.....kekklrakeltkdHkPespeekerieelGGevaak.sGvkRvvWkRprlehng

KKVIDRWPFLGVTRSQGDIWSYSAQSGEYTVSPVPYVCDFPIDLNVQRFIVLASDGLWNVMSPLEVVNFISDTDSKGSCGNSSNsdtnvqRDVVSALIKE
..|||..||| |.||.||.|||.|.|||..|||.|.|... .| | ..||.|||||||||..| ..|........|... ....      |.|..||.||
ptvideiPFLavaRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqs......rsvakalvke

ALGRWSHMKLQADNIAVLIVYLS
||.||...||.|||..|..|.|.
alqrwrskklraDnvsvivvile
0034914 PP2C-like 6-328 9.1e-49 158.9 In-house 21-291 (295) alignment 
Range on Protein: 6-328
Range on HMM: 21-291/295.0
ISAMAETNSGGRPYMEDYIAVYLspkesllsN--PLMREQAFVGVFDGHGGKEAAKYARDHLWSVVQNQ----PKFLTQDSQSVREAISNAYLQLHNTMQ
... . .. | |...||.. |.|        |  .|.......|||||||| .||..|...|.. . ..      .|| .. ...||. .|.|.... . 
lrvgvasdqGrrksneDavlvvl........nllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeell

ESRASwapnkYGDLCTAGTTASTVIFRNNHIYVANVGDSTGIMGvRNPhfgepeepliIPKVLIKDHKPEDPEEQENTRRLGGEIALSLRGvmrvvwere
|   .     . .| . ||||.....|.|..||||||||  ..  ||            .. | .|||| ...|.|  ...|| .  . .          
elall.....rpelagsGtTavvalirgnklyvanvGDSravll.rng..........elvqltvdhkpvnelererilsaggavshgrvn.........

rvesnekkvidrwPFLGVTRSQGDIWSY---SAQSGEYTVSPVPYVCDFPIDLNVQRFIVLASDGLWNVMSPLEVVNFISD----TDSkgscgnssnsdt
             ..| |||. || . .   |    |. ||..|.|. ....|.   |..|||||||.|.|. |.|.....    ...            
.............gvlavtRalGdfdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgld............

nvQRDVVSALIKEALGRWSHmklqaDNIAVLIVYLS
    ... .|...|| |.|.     ||| |..|.|.
..leeaaeeLvdlAlargsr.....DNiTvvvvrln
PP2Cc_SM00332 11-325 9.9e-49 159.2 In-house 15-274 (274) alignment 
Range on Protein: 11-325
Range on HMM: 15-274/274.0
ETNSGGRPYMEDYIAVYLSPKesllsnpLMREQAFVGVFDGHGGKEAAKYARDHLWSVVQNQPKFLTQD-SQSVREAISNAYLQLHNTMQESRASWAPNK
 .. | |  ||| ..|... .          . .|.||||||||.|.||.....|.. .....|. ... ...| ||...|.|.... . |.  |. ...
ssmqgwrksmeDahvvvvdlv.......eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskelen

ygdlCTAGTTASTVIFRNNHIYVANVGDSTGIMGVRNPhfgepeepliiPKVLIKDHKPEDPEEQENTRRLGGeialslrgvmrvvwererveS---Nek
     ..|.||..........||||||||  ...  .             . | .||||||..| .  .. ||                    .   .  
....alsGstavvallkkedlyvanvGDSravlcrngk...........avqlsvdhkpedederkRikkagg....................vvekg..

KVIDRwpfLGVTRSQGDIWSYSAQ-SGEYTVSPVPYVCDFPIdLNVQRFIVLASDGLWNVMSPLEVVNFISDTDSKGscgnSSNSDTNVQRDVVSALIKE
.| .    | |.|. || .   .. . |  ... | |    .  .  .|..|||||||.|.|. |||... .. .||    . |. .... ... ..|. 
rvngg...lavsrafGdhflkknkklkepyitaepdvkvvtl.tsedeflilaSDGlwdvlsnqevvdivrkllakg....ktndpqeaaelldeeairr

algrwshmKLQADNIAVLIV
        .  .||| |..|
........ggseDniTvvvv
PPM_PTC7 38-290 3.3e-48 157.4 In-house 29-238 (259) alignment 
Range on Protein: 38-290
Range on HMM: 29-238/259.0
PLMREQAFVGVFDGHGGKEAAKYARDHLWSVVQNQPKFLTQDsqSVREAISNAYLQLHNTMQESRaswaP--NkyGDLCTAGTTASTVIFRNNHIYVANV
    . ||..||||||| ||||||| ||. ...... | . .   . .|.....|.|.  .   .    .  |      | |.||..........|||||
sgkdsvaffavfdghggreaakyarehleeilkerksfeele..klekalrksflaldtdeelks....sean..tepstsGstAvvalitgsklyvAnv

GDSTGIMGVRNPHFgepeepliipKVLIKDHKPEDPEEQENTRRLGGEIALSlrGVMRVVWErervesnekkvidrwpfLGVTRSQGDIWSYSAQSGEYT
|||  ... ..  .          | | .||||....| |  ...||..     |. ||..                  | |.|. || .... ...|  
GDSravLcrsgnav..........kqltedHkpsnedEreRiegaggsvsnv..gngrvngv.................lavsRafGdfelkpketeeql

VSPVPYVCDFPIDLNvQRFIVLASDGLWNVMSPLEVVNFISDTDSKGscgnssnS
||. |...  .|| . . |..|||||||.|.|. |.| .. .. ||.       .
vsaePdisstkidee.defliLasdGlwdvvsdqeavdlvrselskk.......d
PP2C Protein phosphatase 2C 11-298 1.4e-47 155.4 Pfam-A 6-238 (255) alignment 
Range on Protein: 11-298
Range on HMM: 6-238/255.0
ETNSGGRPYMEDYIAVYLSPKESllsnPLMREQAFVGVFDGHGGKEAAKYARDHLWSVVQNQPKFLTQDsqSVREAISNAYLQlHNTMQESR--ASwapn
....| |  ||| .. . . ..|        . ||..||||||| ||||||| ||. ....|..||. .   |..|.....|. .  ..  .  |.    
selqgarksmedahialknleks....sgkssvaffavfdghggreaakyarehleeilkeqksflele..kvekalrksfla.dtdeelksskan....

kYgDLCTAGTTASTVIFRNNHIYVANVGDSTGIMGVRNPHFgepeepliipKVLIKDHKPEDPEEQENTRRLGGEIALslrgVMRVVWErervesnekkv
      . |.||.....|....||||||||  ... ..  .          | | .||||.|..| |  ...||..      . ||..            
.t.epsksGstavvalirgkklyvAnvGDSravLcrkdnak..........keltedHkpsdedEreRIeeaggsvsn....ngrvngs...........

idrwpfLGVTRSQGDIWSYSAQsgEYTVSPVPYVCDFPIDLNvQRFIVLASDGLWNVMSPLEVVNFISDTDSKGScgnssnsdtnVQRDV
      | |.|. || .... .  |. ||. |.|. .... .   |..|||||||.|.|. |.| .. .. ||..            ...
......LavsRalGdfelkpke..eqlvsaePdvtsvkltee.defliLasdGlwdvlsdqeavdlvrselskkk..........spmea
PP2C Protein phosphatase 2C 11-298 1.4e-47 155.4 In-house 6-238 (255) alignment 
Range on Protein: 11-298
Range on HMM: 6-238/255.0
ETNSGGRPYMEDYIAVYLSPKESllsnPLMREQAFVGVFDGHGGKEAAKYARDHLWSVVQNQPKFLTQDsqSVREAISNAYLQlHNTMQESR--ASwapn
....| |  ||| .. . . ..|        . ||..||||||| ||||||| ||. ....|..||. .   |..|.....|. .  ..  .  |.    
selqgarksmedahialknleks....sgkssvaffavfdghggreaakyarehleeilkeqksflele..kvekalrksfla.dtdeelksskan....

kYgDLCTAGTTASTVIFRNNHIYVANVGDSTGIMGVRNPHFgepeepliipKVLIKDHKPEDPEEQENTRRLGGEIALslrgVMRVVWErervesnekkv
      . |.||.....|....||||||||  ... ..  .          | | .||||.|..| |  ...||..      . ||..            
.t.epsksGstavvalirgkklyvAnvGDSravLcrkdnak..........keltedHkpsdedEreRIeeaggsvsn....ngrvngs...........

idrwpfLGVTRSQGDIWSYSAQsgEYTVSPVPYVCDFPIDLNvQRFIVLASDGLWNVMSPLEVVNFISDTDSKGScgnssnsdtnVQRDV
      | |.|. || .... .  |. ||. |.|. .... .   |..|||||||.|.|. |.| .. .. ||..            ...
......LavsRalGdfelkpke..eqlvsaePdvtsvkltee.defliLasdGlwdvlsdqeavdlvrselskkk..........spmea
subfamily_PPM1A_pd Subfamily PPM1A 8-327 7.1e-39 126.8 In-house 14-280 (282) alignment 
Range on Protein: 8-327
Range on HMM: 14-280/282.0
AMAETNSGGRPYMEDYIAVYLSpkesllsNPLMREQAFVGVFDGHGGKEAAKYARDHLWSVVQNQPKF-----LTQDSQSVREAISNAYLQLHNTMQESR
.  ....| |  |||  .|  |        . .....|  |||||.|.|.|||. .|| . . .. ..       .....|.||.....|.|.....|. 
ygvssmqgwrvemEDahtvvas.......lgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairels

ASWAPNkygDLCtaGTTASTVIFRNNHIYVANVGDSTGIMgVRNPhfgepeepliIPKVLIKDHKPEDPEEQENTRRLGGEIAlslrgvmrvvW-----E
..   .   | .  |.|| ||. ...|...||.||| ... .||             . | .||||..|.|..  .  ||..                  
tdlkta...dks..GsTavtvlvsekhliianlGDsRavl.crng..........kaaflteDHkpsrpkEkkRieqAGGsvv..........vsRvnGa

rervesnekkvidrwpfLGVTRSQGDIWSYS---AQSGEYTVSPVPYVCDFPIDLNVQrFIVLASDGLWNVMSPLEVVNFISDTDSKGSCGNSSnsdtnv
                 | |.|. ||    .    .. |  ||..|.|  . .. . . |.|||.||.| |.|  |||... .. ....  ..       
.................LAvsRalGDyeykeeeekkaeeqlvsaepevtsierseedd.flvlacDGiwDvlsdeevvelvrkrlevadeleev......

qrdvVSALIKEALGRWSHmklqaDNIAVLIVYL
    ..||...|| . |.     ||..||.| .
....akalvdkalekgsr.....DNlsvlvvlf
0049733 PP2C-like 7-327 4.4e-35 114.2 In-house 4-233 (235) alignment 
Range on Protein: 7-327
Range on HMM: 4-233/235.0
SAMAETNSGG-RPYMEDYIAVylspkesllsnplmrEQAFVGVFDGHGGKEAAKYARDHLWSVVQNQPKFltQDSQSVREAISNAYLQLHNTMQESRASW
|. | .  |  |...||...|               ......|.||||| .|...|...|....... .   ... ...||. .|.|.... . |   ..
svgaasdigrvrkvneDavlv...............glllfavaDGhgghaagevasellvetllellle..lllldleealrkaflaaneallelalas

ApnkygDLCTAGTTASTVIFRNNHIYVANVGDSTGIMGvRNPHfgepeepliiPKVLIKDHKPEDPEEQENTRRLGGEIalslrgvmrvvwerervesne
      .| . ||||..........||||||||  ..  |. .             | .||.| ...|..  ...|| .                     
p.....elagmgtTavvalldggklyvanvGDsrayll.rdgk..........lvqltedhspvnelerqriitaggav.....................

kkviDRWPFLGVTRSQGDIWSYsaqsgeytvspvPYVCdfPIDLNVQRFIVLASDGLWNVMSPLEVVNFISDTDSkgscgnssnsdtnvqRDVVSALIKE
       . | .||. || .              |.|.   ..|. . |..|||||||.|.|. |.|......|                ......|...
....rvpgrlaltralGdlllk............pdvt..vlelepgdflllasDGlwdvlsdeeivdllrsldl...............eeaaerlvel

ALGRWSHmklqaDNIAVLIVYL
|| |...     ||| |..|.|
alarggr.....DNiTvvvvrl
subfamily_PPM1E_pd Subfamily PPM1E 15-328 1.7e-31 102.4 In-house 13-263 (265) alignment 
Range on Protein: 15-328
Range on HMM: 13-263/265.0
GGRPYMEDYIAVYLSpKESLLSNPLMREQAFVGVFDGHGGKEAAKYARDHLWSVVQNQPKFLTQDSqsvreaisnayLQLHNTMQESRASWAPNKYGDLC
. |  |||   .. .  ..|.    ..|.|| .||||||| ||||||  ||.... .|.|. ..              .|......   .       .  
nkrrkmEDrhvaled.lnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa...........ealkeafkltDerflqkaerekl

TAGTTASTVIFRNNHIYVANVGDSTGIMgVRNPHFGEpeepliipkvLIKDHKPEDPEEQENTRRLGGEIALSlrGVMRVvwerervesNEKkvidrwpf
..|.|| .|. .....||| .||| ... ||. .. .          |.| ||||...|..    .|| .     |..||         |          
ksGstavvvliekdqlyvaWlGDsqall.vrkgeavq..........lmkpHkPeredEkkRieeagGlvvvi..gawRv.........nGv........

LGVTRSQGDiwsysaQSGEYTVSPVPYVCDFPIDlNVQRFIVLASDGLWNVMSPLEVVNFISDTDSKgscgnssnsDTNVQRDVVSALIKEALGRWSHmk
| |.|. ||      .. .  ||  . |.....| . . ...||.||||.|. . |||. ...  ..         ... . .|   |...|  . |.  
LsvsRaiGD......vklkpyvsgeadvaeveld.gseeylilacDGlwDvvneeevvklveeflad.........gaedlsevakllveaakeagss..

lqaDNIAVLIVYLS
   |||.|..|.|.
...Dnitvvvvfld
subfamily_PPM1G2_pd Subfamily PPM1G2 32-327 6.4e-31 100.3 In-house 41-286 (287) alignment 
Range on Protein: 32-327
Range on HMM: 41-286/287.0
ESLLSNPLMREQAFVGVFDGHGGKEAAKYARDHLWSVVQNQPKFLtqdSQSVREAISNAYLQLHNTMQESraswapNKYGDlCTAGTTASTVIFRNNHIY
. ||...  .. |...|||||||...||||  .| ........|    ........ .|.|.. . ...       .|  |  .||.|| .|. .....|
nelleksddkslalfavfDGhGGakvakyagkklikkiakkksfk...egaleqilkdafletDeellkd......eklkd.esaGstavvvlikeekly

VANVGDSTGIMGVRnphfGEpEepliipKVLIKDHKPEDPEEQENTRRLGGEIALSlRGVMRVVWERERVESNEKKVIDrwpflgvtrsqgdiwsysAQS
|||.|||  .. ..    |.        | |  ||||.. .|..     || ..|  |    .   |   . . ||                      ..
vanaGDsravlssk....gn.v......kalsfDhkPqeesekkriiaagGfveln.rvngnLalsralgDfefkknvk..................kkp

GEYTVSPVPYVCDFPIDlNVQRFIVLASDGLWNVMSPLEVVNFISDTDSKGscgnsSNSDtnvqrDVVSALIKEALGRWSH-MKLQADNIAVLIVYL
 |  |  || |    .| . . |.||| ||.|.|..  |||...    ..|      . |     .... |....| . |.   . .||..|.|| |
eeqivtavPDvlvkkld.eddeflvLaCDGiWDvltnkevvdlvrerlvsg.....akld.....eiieelldkclapdssntgvGcDnmtvvivvl
subfamily_ILKAP_pd Subfamily ILKAP 8-327 1.1e-30 99.8 In-house 7-292 (293) alignment 
Range on Protein: 8-327
Range on HMM: 7-292/293.0
AMAETNSGGRPYMEDYIAVYLSPK-ESLLSNPLMREQAFVGVFDGHGGKEAAKYARDHLWSVVQNQ-PKFL-TQDSQSVREAISNAYLQLHNTMQESRAS
..     | |  |.|   .  . . .. |.. |.   .. .|||||.|. |...| ..|  .. .. ||   ..  .... .. ... .  . . .  ..
gayaerkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefLklask

WAPnKYGDlctaGTTASTVIFRNNHIYVANVGDSTGIMGVRNPHFGEpeeplIIPKVLIKDHKPEdpeeqentrrlggeialslrgvmrVVWERERVESN
  | .. |    |.|| .|.  .| .||||.|||  ..  ....  .     |.  || |||.|                            ||.|..  
akP.vWkd....GstatvvlvldnvlyvanlGdskavlvrkkeegdk.....iasvvLtkdhtpv........................kyeerkriqka

EKKVIDR--WPFLGVTRSQGDIwSYSaqsgEYTVSPVPYVCDFPIDLNvQRFIVLASDGLWNVMSPLEVVNFISDTDSKG-SCGNSSNSDTNVQRDVVSA
  .| |      |.|.|| ||   .     .  |. .| |    .. |  .|.||| ||||.|.|  |||.||...  .  .  . ...... ...|   
GgvvrdgrvlGvlevsrsiGdg.rfk....rlGvistPdvkkceLten.dlfvvlaCdGLwkvfsadevvkfilkvledeeddrkikeeekkskeevrfe

LIKEALGRWSHMKLQADNIAVLIVYL
.. . |   .  .  .||..||.| .
vacnrlaseavkrgssdnvtvllvki
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 14-280 1.3e-25 83.1 In-house 14-225 (255) alignment 
Range on Protein: 14-280
Range on HMM: 14-225/255.0
SGGRPYMEDYIAVYLSPKESllsnplmREQAFVGVFDGHGGKEAAKYARDHLWSVVQNqpkFLTQDSQSVREAISNAYLQLHNTMqesraswapNKYGdl
 | || ||| ...| | ..         .. .. .||||||..|||.| ..|  ....   .|   . .  ... .|| ...  .         ....  
iGrrptmedelviyGsfrdk.......sdedyyalfdGhgGraaakfaseelykilae...lldlnnanPvkslkkaykeistqi.........serp..

CTAGTTASTVIFRNNHIYVANVGDSTGIMGvrnphfgepeEPLIIPKVLIKDHKPEDPEEQENTRRLGGEIALSlrgvmrvvwerervesnekKVIDR-W
   |||| .|.. ....|.||||||  ...          .   . | |  |||| ...|..  ..||| .  .                   .|  |  
kfiGttaasvliiedkvyianvGdsrvvlc..........qkdgtakrlsldhkPseeseekriselGGtvvst...................vvtsrvn

PFLGVTRSQGDIWSysaqsgEYTVSPVPYVCDFPIDLNVQRFIVLASDGLWNVMSPLEVVNFISDTDS
  | |.|. ||..       |  | | |.. .     . ..|..|| ||.|...|  | |. . .  .
GtlavsralGdsfl......ePfvvpdPdlsqsleiskkdkflilacdGiwdlisdeeaveivagisd
PPM_PTC7_SpoIIE 38-281 1.8e-22 73.3 In-house 29-211 (230) alignment 
Range on Protein: 38-281
Range on HMM: 29-211/230.0
PLMREQAFVGVFDGHGGKEaaKYARDHLWSVVQNQPkFLTQDsqSVREAISNAYLQLHNTMQESraswapnkygdLCTAGTTASTVIFRNNH--IYVANV
.  |  ..||..||||| .  ..|. .|.......  | . .   . |......|.|.  ....             . |.||. .......  .||||.
sggrlalvvgdvdGhGgra..alamgllrtalrela.fagle..kpeeilrrlnlalaadlede...........psssgaTavvalidpstgklyvana

GDSTGIMGVRNPHfgepeepliipkvlikdhkpedpeeqENTRRlGGEIALS--L-RGvmRVVWErervesnekkvidrwpfLGVTRSQGDIWSYSaqsG
|||  ..   ...                          | .|  ..  ..|  .  |  ||...                 | |... ||.. .     
Gdsppllvrddgg..........................ereri.vagglpslGilpg..rvfgv.................lavslapGdlllly...t

EYTVSPVPYvCDFPIDLNVQRFIVLASDGLWNVMSPLEVVNFISDTDSK
.  |.. |.  .  .. ....|..|||||||.|.|| |.| .. |. .|
DGvveaepd.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelek
subfamily_PPM1L_pd Subfamily PPM1L 15-285 4.4e-22 71.6 In-house 14-242 (269) alignment 
Range on Protein: 15-285
Range on HMM: 14-242/269.0
GGRPYMEDYIAVYLSPKESllsnplmREQAFVGVFDGHGGKEAAKYARDHLWSVVQNQPKFLTQDSqSVREAISNAYLQLHNTMQESRASWAPNKYgDLC
| || ||| . .    |..        .. |..|||||||. ||..|.| |   ..|. . | .|     | |. . |  .. .   .      |     
Grrprmedrfeieediknk.......tgesffavfdGhGGefaaefakdvlvkaiknklieldadk.entepinfsklltdeilsvdekllekakr.aed

TAGTTASTVIFRNNHIYVANVGDSTGIMGVRNphfGEpeeplIIPkvLIKDHKPEDPEEQENTRRLGGEIAlsLRGVMRVvwerervESnekkvidrwpF
.|||||   . ..... ||||||| |..  ..   |.      ||  |  ||||....|.   .. || ||  .||| ||       .            
iaGttalialvqesdlivanvGdsrGvlydkr...Gk.....aip..lsfdhkpqqvkerkrikkaGGfia..frGvwrv.......aG..........v

LGVTRSQGDiwsYSAQSGEyTVSPVPYVCDFPIDLNVQRFIVLASDGLWNVMSPLEVVNFISDTDSKGSCG
| ..|. ||   |  .  .  | . | .  | .|    .|..|||||||. .|  | |.|| .  ..   |
latsralGd...yplkdkn.lviadpdiltfdlddhkpeflilasdGlwdtfsneeavrfikerlkepdfG
subfamily_PPM1K_pd Subfamily PPM1K 40-278 4.1e-20 65.0 In-house 28-228 (263) alignment 
Range on Protein: 40-278
Range on HMM: 28-228/263.0
MREQAFVGVFDGHGGKEAAKYARDHLWSVVQnqpkFLTQDSQSVREAISNAYLQLHNTMQESRASWAPNKygDLCTAGTTASTVIFRN-NHIYVANVGDS
  |  .|.|||||.|  ||... |.|  ...    .| .  . ... . ||...|.. ..       ...  .| ..||||. ...|. ... .|..|||
dpellyvavfdGhaGsaaadfvhdklekilk....rllekekdleivlknafeeldkklkrylefsvaea..ellssGttatvsllrdGtelvlaslGds

TGIMgVRNphfGEpeepliiPKVLIKDHKPEDPEEQENTRRLGGEIALSLRGVMRVvwerervESNekkvidrwpfLGVTRSQGDIwsysaQSGEYTVSP
  |.  ||   |.       .| | .||.||  ||.|  .. || .. .  | ..|       ..           | .||| ||.     .  .| |  
rail.crn...Gk.......akkltrdhdPeleeekerikaagGsvewnslgkplv.......ngr..........lamtrslGdl.....dlkryGvia

VPYVCDFPIDLNVQRFIVLASDGLWNVMSPLEVVNFISDT
 |    . .| . . |.|| .||. .|..  |. ....  
tPetkslkvdhaadsflvlitdgisfvvnsqelcdlvrlc
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 45-200 4.7e-16 52.2 In-house 22-169 (292) alignment 
Range on Protein: 45-200
Range on HMM: 22-169/292.0
F-VGVFDGHG--GKEAAKYARDHLWSVVQNqpkfLTQDSQSVREAISNAYLQLHNTMQESRASwapnkygDLCTAGTTASTVIFRNN-HIYVANVGDSTG
|   |.||||  |.. |..| |.|   . .    ||.. | . ||. .  |..   .... .            |.|..   . |..  ...||||||  
flaavldGhGvnGdkvaqlaedtlevelle....ltrqlqelsealllrildiaakldkltid.......aresattavvcarvrddralilanvGdsra

IMGVRnphFGEPEEPLiIPkvLIKDHKPEDPEEQENTRRLGGEIA------LSLRGVMRVvWERER
..|     .|  .  | ||  | .|||||||.|..  .| || .          ||  || | | .
llgrc...lggsdyel.iP..lsrdhkPedPderarilraGGrveptrvrgwgfrGtarv.wrrrq
subfamily_PPM1G_pd Subfamily PPM1G 41-99 5e-10 32.0 In-house 45-100 (473) alignment 
Range on Protein: 41-99
Range on HMM: 45-100/473.0
REQAFVGVFDGHGGKEAAKYARDHLWSVVQNQPKFltqDSQSVREAISNAYLQLHNTMQ
 . .. .|.||||||| |||  ..|  ....|  .   .   |..|...|.|.| ....
edtslfavyDGHGGkevakyvakklpdllkaqkgy...kegdvekaleeaflalDeklk
subfamily_KAPP-like_pd Subfamily KAPP-like 18-178 9.8e-10 30.9 In-house 10-155 (266) alignment 
Range on Protein: 18-178
Range on HMM: 10-155/266.0
PYMED-YIAVYLSPKESLLSNplMREQAFVGVFDGHGGKEAAKYARDHLWSVVQNQPKFLTQDsqSVREAISNAYLQLHNTMQESRASWAPNKYgDLCTA
  ||| ..|.|   ||  |||    . |. .||||| || ||. |.. .  ..... |   ||     . | .    |.|...|  |     .| . .||
temedvslaiypllkekklsn..csnialfavfdGhaGkGaadaakklfpkelekllkstkqd..dGGdniydqskllenafkevdaklkdfey.eGata

GTTASTVIFRNNHIYVANVGDSTGIMGVRNphfgepeEPLiipkVLIKDHKPEDPEEQENTR
  .      .  .. |||||||. ..   |       | |     | |||| .||||.   .
tlalvwsdGqqrylqvanvGdssaflsrGn.......esl....elskdhkakdpeekqrik
subfamily_PPM1G_pd Subfamily PPM1G 116-189 2.1e-09 29.9 In-house 296-358 (473) alignment 
Range on Protein: 116-189
Range on HMM: 296-358/473.0
AGTTASTVIFRNNHIYVANVGDSTGIMGVRnphfgepeeplIIPKVLIKDHKPEDPEEQENTRRLGGEIALSLR
.||||  .. ......|||.|||  ..                   |  ||||||..|.|  .. ||..   .|
sGttAvvaLlkekklivAnaGDsRcvlsrn...........GkAldlslDHkPeDevEleRiekAGGkvdedgR
Subfamily Dicty-PPM1L-like 41-138 5.5e-09 28.3 In-house 35-137 (305) alignment 
Range on Protein: 41-138
Range on HMM: 35-137/305.0
REQAFVGVFDGHGGKEAAKYARDHLWSVVQNQPKFLT--------QDSQSVREAISNAYLQLHNTMQESraSWAPNKYGDLCTAGtTASTVIFRNNHIYV
.|. . ||||||.|. ||.|.. .|  .| .  |             ...  |||..|.|.  . . .|  . . || .     | ....||. .. . |
qelslfGvfdGhnGdiaaeyvkkklveivnkyvkenkvGysaknlnvddlpleaiksaslstdksslds..aesdnkkaGttlng.ssasvilerertiv

ANVGDS
.. .|.
stasdt
subfamily_PDP_pd Subfamily PDP 75-148 2.2e-08 26.6 In-house 107-184 (398) alignment 
Range on Protein: 75-148
Range on HMM: 107-184/398.0
FLTQDSQSVREAISNAYLQLHNTMQESRASWAPNKYG----DLCTAGTTASTVIFRNNHIYVANVGDSTGIMGVRNPH
 |  . ..|.||...|.|.| . ...   . ...|      .  ..|..| ..  ......|||.||.  ..||....
lleaevekvkealkkaFlklDkdistealkklkekslreallvalsGacallaliegtelhvAntGDcravlgvqeee
subfamily_PPM1G_pd Subfamily PPM1G 252-306 9.6e-08 24.4 In-house 402-448 (473) alignment 
Range on Protein: 252-306
Range on HMM: 402-448/473.0
QRFIVLASDGLWNVMSPLEVVNFISDTDSKGSCGnssnsdtnVQRDVVSALIKEA
. |.|||.||.||||.  |||.|. .  .||.          |  ..| .|. ..
deFlvlAcDGiWnvmesqevvdfvraklkkgees........vlseiveeLlDac
PPM_PTC7_motif 256-278 1.1e-07 25.2 In-house 1-23 (51) alignment 
Range on Protein: 256-278
Range on HMM: 1-23/51.0
VLASDGLWNVMSPLEVVNFISDT
.|||||||.|.|. |.|... |.
iLAsDGLWDvlsdqeavdlvrdq
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 18-178 1.9e-07 23.2 In-house 9-165 (276) alignment 
Range on Protein: 18-178
Range on HMM: 9-165/276.0
PYMED-YIAVYLSPKESLLSNplMREQAFVGVFDGHGGKEAAKYARDHLWSVVQNQPKF----LTQDSQSVrEAISNAYLQLHNTMQESRASWAPNKYGD
  ||| ..|.|   .|  |||    . |. .||||| || ||. |.. .  ...   |     ||.. .   . | .    | . ..|  |     .|  
temedvslaiyplldekdlsn..csnialfavfdGhaGkGaadaakklfpkelekllksgnysltkqddGG.dniydqskllldlfkevdaklkdfeyeG

lCTAGTtasTVIF---------RNNHIYVANVGDSTGIMGVRNphfgepeEPLiipkVLIKDHKPEDPEEQENTR
 .||     ....         .. .. |||||||. ..   |       | |     | |||| .||||..  .
.atatl...alvwsdGeeqqqqqqrylqvanvGdssaflsrGn.......esl....elskdhkatdpeekqrik
subfamily_PDP_pd Subfamily PDP 251-299 2.8e-07 23.0 In-house 284-333 (398) alignment 
Range on Protein: 251-299
Range on HMM: 284-333/398.0
VQRFIVLASDGLWNVMSPLEVVNFISDTDSKGSCGNSS-NSDTNVQRDVV
 ..|.|||.||||...|. |||. ...  .|    ..   ......   |
ndkFLvlatDGLwdllsneevvslVgehlakkkekepvkveeakltlkqv
subfamily_PP2D1_pd Subfamily PP2D1 230-278 2.1e-06 19.7 In-house 258-305 (492) alignment 
Range on Protein: 230-278
Range on HMM: 258-305/492.0
QSGEYTVSPVPYVCDFPIDLNVQrFIVLASDGLWNVMSPLEVVNFISDT
.  . .| | |..   ..| . | |.|||| |||.|.|  ||.. . .|
pkLkksvipePkttsvkldeaaq.flvlAsnGlWevlseeevlsLvkqt
subfamily_TAB1_pd Subfamily TAB1 116-184 3e-06 19.2 In-house 129-189 (333) alignment 
Range on Protein: 116-184
Range on HMM: 129-189/333.0
AGTTASTVIFRNNHIYVANVGDSTGIMGVRNPhfgepEEPLiipKVLIKDHKPEDPEEQENTRRLGGEI
 ||||  ..  ||..||||||||  ..  |..     .|     | | .||. . ..| .  ..|| .|
gGttAvvalifnnkLyVaNvGdsrAllvkrke.....sekv...kqLsvdHttdNedEllRlkdLGldi
PP2C_SIG_SM00331 43-140 8e-06 18.6 In-house 30-112 (217) alignment 
Range on Protein: 43-140
Range on HMM: 30-112/217.0
QAFVGVFDGHG-GKEAAKYARDhLWSVVQNQPKFLTQDSQSVREAISNAYLQlhntmqesraswapnkyGDLCTAGTTASTVI--FRNNHIYVANVGDST
. .. |.||.| |..|| ...  | ...... .  .  || ...... .| .                  . .  ..|.   .  |.......||.||| 
rlllvvaDgmGkGlaAaaassq.lrtalrellsegeelsqalkrlnraiyee.................keekgmfaTlllalydfssgklsyanaGdsr

G
 
p