Gene PPM1D-2 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1D
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP209_AA protein Get Run
AqueP209_AA_5-330 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1D_pd Subfamily PPM1D 8-330 1.6e-137 450.7 In-house 2-308 (309) alignment 
Range on Protein: 8-330
Range on HMM: 2-308/309.0
ISVTAETNAGGRKHMEDYIAVSLSPKESLLsnpeMREQAFVGVFDGHGGKEAAKYARENLWSVIQDQSNFLTQDPQSVREAISNAYLQLHNTMEESRASW
.|||.|...||||.|||..|..|...||..    ..|.|||.||||||||||||.|||.|||||..|..||...|..|.|||..|.|..|..|......|
lsvtseadqGgrkymeDvvaivleeeesae....elevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeW

VPNKTGDLSTAGTTASTVIFRKNHIYVANVGDSTGIMGVRNPrygepGEPQIIPKLLTKDHKPEDPEEQENIRRLGGEVALSlKGVMRVVWERMRVKSNG
...|.|.|||||||||.||.|....|||.||||. ..||..|     .|.....| ||||||||.|||.|.|..|||||| . .||.||||.|.|...||
pktksgllstaGttasvviirreklyvahvGDsaivlgvkep.....kekklrakeltkdHkPespeekerieelGGevaak.sGvkRvvWkRprlehng

KKEIDRIPFLSVARSLGDFWSYSAQSGEYTVSPVPYVYDFPLDLNEQKFIVLASDGLWNVMSPSDVVNFISDFDSKGTSGSNNSsdtnvqRDVVSALIKE
...||.||||.|||||||.|||.|.|||..|||.|.|... || ||.|||.|||||||||..|.|.|..... ..|..  ...|      |.|..||.||
ptvideiPFLavaRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqs......rsvakalvke

ALSRWSRKKLQADNIAVLIAYLS
||.||..|||.|||..|.. .|.
alqrwrskklraDnvsvivvile
PP2C Protein phosphatase 2C 11-311 4.7e-56 183.2 Pfam-A 4-249 (255) alignment 
Range on Protein: 11-311
Range on HMM: 4-249/255.0
TAETNAGGRKHMEDYIAVSLSPKESllsnPEMREQAFVGVFDGHGGKEAAKYARENLWSVIQDQSNFLTQDpqSVREAISNAYLQlHNTMEESR--ASwv
.|... | ||.||| ..   . ..|        . ||..||||||| ||||||||.|. ... |. ||. .   |..|.....|. .  .|  .  |.  
gaselqgarksmedahialknleks....sgkssvaffavfdghggreaakyarehleeilkeqksflele..kvekalrksfla.dtdeelksskan..

pnkTgDLSTAGTTASTVIFRKNHIYVANVGDSTGIMGVRNPRYgepgepqiipKLLTKDHKPEDPEEQENIRRLGGEVALslkgVMRVVWErmrvksngk
   |   |. |.||.....|....||||||||  ... ..  .          | ||.||||.|..| | |...||.|      . ||..          
...t.epsksGstavvalirgkklyvAnvGDSravLcrkdnak..........keltedHkpsdedEreRIeeaggsvsn....ngrvngs.........

keidripfLSVARSLGDFWSYSAQsgEYTVSPVPYVYDFPLDLNeQKFIVLASDGLWNVMSPSDVVNFISDFDSKGTsgsnnssdtnVQRDVVSALIKEA
        |.|.|.||||.... .  |. ||. |.|. ..|. .  .|..|||||||.|.|. ..| .. .. ||..            ...  .|..||
........LavsRalGdfelkpke..eqlvsaePdvtsvkltee.defliLasdGlwdvlsdqeavdlvrselskkk..........spmeaaeelvdea

LSR
..|
iar
PP2C Protein phosphatase 2C 11-311 4.7e-56 183.2 In-house 4-249 (255) alignment 
Range on Protein: 11-311
Range on HMM: 4-249/255.0
TAETNAGGRKHMEDYIAVSLSPKESllsnPEMREQAFVGVFDGHGGKEAAKYARENLWSVIQDQSNFLTQDpqSVREAISNAYLQlHNTMEESR--ASwv
.|... | ||.||| ..   . ..|        . ||..||||||| ||||||||.|. ... |. ||. .   |..|.....|. .  .|  .  |.  
gaselqgarksmedahialknleks....sgkssvaffavfdghggreaakyarehleeilkeqksflele..kvekalrksfla.dtdeelksskan..

pnkTgDLSTAGTTASTVIFRKNHIYVANVGDSTGIMGVRNPRYgepgepqiipKLLTKDHKPEDPEEQENIRRLGGEVALslkgVMRVVWErmrvksngk
   |   |. |.||.....|....||||||||  ... ..  .          | ||.||||.|..| | |...||.|      . ||..          
...t.epsksGstavvalirgkklyvAnvGDSravLcrkdnak..........keltedHkpsdedEreRIeeaggsvsn....ngrvngs.........

keidripfLSVARSLGDFWSYSAQsgEYTVSPVPYVYDFPLDLNeQKFIVLASDGLWNVMSPSDVVNFISDFDSKGTsgsnnssdtnVQRDVVSALIKEA
        |.|.|.||||.... .  |. ||. |.|. ..|. .  .|..|||||||.|.|. ..| .. .. ||..            ...  .|..||
........LavsRalGdfelkpke..eqlvsaePdvtsvkltee.defliLasdGlwdvlsdqeavdlvrselskkk..........spmeaaeelvdea

LSR
..|
iar
PPM_PTC7 13-296 8.5e-55 179.0 In-house 6-238 (259) alignment 
Range on Protein: 13-296
Range on HMM: 6-238/259.0
ETNAGGRKHMEDYIAVSLSPKESllsnPEMREQAFVGVFDGHGGKEAAKYARENLWSVIQDQSNFLTQDpqSVREAISNAYLQLHNTMEESRaswvP--N
. . | ||.|||  ..      |        . ||..||||||| ||||||||.|. ... .. | . .   . .|.....|.|.  .|  .    .  |
safqgfrksmedahialanless....sgkdsvaffavfdghggreaakyarehleeilkerksfeele..klekalrksflaldtdeelks....sean

kTgDLSTAGTTASTVIFRKNHIYVANVGDSTGIMGVRNPRYgepgepqiipKLLTKDHKPEDPEEQENIRRLGGEVALSlkGVMRVVWErmrvksngkke
 |   || |.||..........||||||||  ... ..  .          | ||.||||....| | |...||.|     |. ||..            
.t.epstsGstAvvalitgsklyvAnvGDSravLcrsgnav..........kqltedHkpsnedEreRiegaggsvsnv..gngrvngv...........

idripfLSVARSLGDFWSYSAQSGEYTVSPVPYVYDFPLDLNeQKFIVLASDGLWNVMSPSDVVNFISDFDSKGtsgsnnssdtnV
      | |.|..|||.... ...|  ||. |...  ..| . ..|..|||||||.|.|. ..| .. .. ||.            
......lavsRafGdfelkpketeeqlvsaePdisstkidee.defliLasdGlwdvvsdqeavdlvrselskk...........d
0034914 PP2C-like 6-330 1.7e-54 177.6 In-house 19-291 (295) alignment 
Range on Protein: 6-330
Range on HMM: 19-291/295.0
VTISVTAETNAGGRKHMEDYIAVSLSP-----KesllsnpemreQAFVGVFDGHGGKEAAKYARENLWSVIQDQ----SNFLTQDPQSVREAISNAYLQL
  ..| . .. | ||..||.. | |.      .           ....|||||||| .||..|.|.|.. . ..     ..|| .. ...||. .|.|..
lllrvgvasdqGrrksneDavlvvlnllslled...........lllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaa

HNTMEESRASWvpnktGDLSTAGTTASTVIFRKNHIYVANVGDSTGIMGvRNPrygepgepqiIPKLLTKDHKPEDPEEQENIRRLGGEVALslkgV--M
.. . |   ..      .|.. ||||.....|.|..||||||||  ..  ||            .. ||.|||| ...|.| |...|| |         .
deellelallr.....pelagsGtTavvalirgnklyvanvGDSravll.rng..........elvqltvdhkpvnelererilsaggavsh....grvn

rvvwermrvksngkkeidriPFLSVARSLGDFWSY---SAQSGEYTVSPVPYVYDFPLDLNEQKFIVLASDGLWNVMSPSDVVNFISDFDSKGTSgsnns
                    ..| | |.||||. .   |    |. ||..|.|. ..|.|.. .|..|||||||.|.|....|...... .||..     
....................gvlavtRalGdfdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgld.....

sdtnvQRDVVSALIKEALSRWSRkklqaDNIAVLIAYLS
       ... .|...||.|.||     ||| |....|.
.....leeaaeeLvdlAlargsr.....DNiTvvvvrln
PP2Cc_SM00332 13-326 3.6e-54 177.0 In-house 15-273 (274) alignment 
Range on Protein: 13-326
Range on HMM: 15-273/274.0
ETNAGGRKHMEDYIAVSLSPKesllsnpEMREQAFVGVFDGHGGKEAAKYARENLWSVIQDQSNFLTQD-PQSVREAISNAYLQLHNTMEESRASWVPNK
 .. | || ||| ..| .. .       |  . .|.||||||||.|.||.....|.. .... .. ...  ..| ||...|.|.... . |.  |. ...
ssmqgwrksmeDahvvvvdlv.......eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskelen

tgdlSTAGTTASTVIFRKNHIYVANVGDSTGIMGVRNPrygepgepqiiPKLLTKDHKPEDPEEQENIRRLGGevalslkgvmrvvwermrvkS--NGkk
    ...|.||......|...||||||||  ...  .             . |..||||||..| . |.. ||                    .  .|  
....alsGstavvallkkedlyvanvGDSravlcrngk...........avqlsvdhkpedederkRikkagg....................vvekg..

eiDRIPFLSVARSLGDFWSYSAQ-SGEYTVSPVPYVYDFPLdLNEQKFIVLASDGLWNVMSPSDVVNFISDFDSKGtsgsnnssDTNVQRDVVSALIKEA
       |.| |..||..   .. . |  ... | |.   |  .| .|..|||||||.|.|. .||... .. .||         ||   ..   |..||
..rvngglavsrafGdhflkknkklkepyitaepdvkvvtl.tsedeflilaSDGlwdvlsnqevvdivrkllakg........ktndpqeaaelldeea

LSRwsrkKLQADNIAVLI
..|    .  .||| |..
irr....ggseDniTvvv
subfamily_PPM1A_pd Subfamily PPM1A 6-327 1.6e-45 148.6 In-house 10-278 (282) alignment 
Range on Protein: 6-327
Range on HMM: 10-278/282.0
VTISVTAETNAGGRKHMEDYIAVSLSpkesllsNPEMREQAFVGVFDGHGGKEAAKYARENLWSVIQDQSNF-----LTQDPQSVREAISNAYLQLHNTM
 .. .. ... | |..|||  .|  |        .......|  |||||.|.|.|||. ..| . | .....       .. ..|.||.....|.|....
nglrygvssmqgwrvemEDahtvvas.......lgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeai

EESRASwvpNKTGdlSTAGTTASTVIFRKNHIYVANVGDSTGIMgVRNPrygepgepqiIPKLLTKDHKPEDPEEQENIRRLGGEVAlslkgVMRVVWEr
.|. ..   .||     .|.|| ||. ...|...||.||| ... .||             . ||.||||..|.|.. |.  ||.|      | ||    
relstd...lkta..dksGsTavtvlvsekhliianlGDsRavl.crng..........kaaflteDHkpsrpkEkkRieqAGGsvv.....vsRvnGa.

mrvksngkkeidripfLSVARSLGDFWSYS---AQSGEYTVSPVPYVYDFPLDLNEQkFIVLASDGLWNVMSPSDVVNFISDFDSKGtSGSNNSsdtnvq
                | |.|.|||.   .    .. |  ||..|.|. .  . ... |.|||.||.| |.| ..||... .  ... .. ..       
................LAvsRalGDyeykeeeekkaeeqlvsaepevtsierseedd.flvlacDGiwDvlsdeevvelvrkrleva.deleev......

rdvVSALIKEALSRWSRkklqaDNIAVLIA
   ..||...||.. ||     ||..||. 
...akalvdkalekgsr.....DNlsvlvv
0049733 PP2C-like 8-329 2.6e-40 131.3 In-house 3-233 (235) alignment 
Range on Protein: 8-329
Range on HMM: 3-233/235.0
ISVTAETNAGG-RKHMEDYIAVslspkesllsnpemrEQAFVGVFDGHGGKEAAKYARENLWSVIQdqSNFLTQDPQSVREAISNAYLQLHNTMEESRAS
.|| | .  |  ||..||...|               ......|.||||| .|...|.|.|.....  . .|.... ...||. .|.|.... . |   .
lsvgaasdigrvrkvneDavlv...............glllfavaDGhgghaagevasellvetll..elllelllldleealrkaflaaneallelala

WVpnktgDLSTAGTTASTVIFRKNHIYVANVGDSTGIMGvRNPRygepgepqiiPKLLTKDHKPEDPEEQENIRRLGGEValslkgvmrvvwermrvksn
.      .|.. ||||..........||||||||  ..  |. .             ||.||.| ...|.. |...|| |                    
sp.....elagmgtTavvalldggklyvanvGDsrayll.rdgk..........lvqltedhspvnelerqriitaggav....................

gkkeiDRIPFLSVARSLGDFWSYsaqsgeytvspvPYVYDFPLDLNEqkFIVLASDGLWNVMSPSDVVNFISDFDSkgtsgsnnssdtnvqRDVVSALIK
       .. | . |.|||..              |.|. ..|. ..  |..|||||||.|.|....|..... |                ......|..
.....rvpgrlaltralGdlllk............pdvtvlelepgd..flllasDGlwdvlsdeeivdllrsldl...............eeaaerlve

EALSRWSRkklqaDNIAVLIAYL
.||.|..|     ||| |....|
lalarggr.....DNiTvvvvrl
subfamily_PPM1E_pd Subfamily PPM1E 8-330 5.5e-37 120.4 In-house 4-263 (265) alignment 
Range on Protein: 8-330
Range on HMM: 4-263/265.0
ISVTAETNAGGRKHMEDYIaVSLSPKESLLSNPEMREQAFVGVFDGHGGKEAAKYARENLWSVIQDQSNFlTQDPQsvreaisnayLQLHNTMEESRASW
..|....  . |..|||   |.|.  ..|.   ...|.|| .||||||| |||||| ..|.... .|... ..||.           .|......   . 
yevsiaavknkrrkmEDrh.valedlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqekl.kedpa..........ealkeafkltDerf

VPNKTGDLSTAGTTASTVIFRKNHIYVANVGDSTGIMgVRNprygepGEpqiiPKLLTKDHKPEDPEEQENIRRLGGEVALSlkGVMRVvwermrvksNG
.   . .  ..|.|| .|. .|...||| .||| ... ||.      ||       |.| ||||...|.. |  .|| |     |..||         ||
lqkaereklksGstavvvliekdqlyvaWlGDsqall.vrk......ge....avqlmkpHkPeredEkkRieeagGlvvvi..gawRv.........nG

KkeidripfLSVARSLGDfwsysaQSGEYTVSPVPYVYDFPLDlNEQKFIVLASDGLWNVMSPSDVVNFISDFDSKGTSgsnnsSdtnvQRDVVSALIKE
         |||.|..||      .. .  ||  . | ...|| .......||.||||.|. ...||. ...| ..|..     .    . .|   |...
v........LsvsRaiGD......vklkpyvsgeadvaeveld.gseeylilacDGlwDvvneeevvklveefladgae.....d....lsevakllvea

ALSRWSrkklqADNIAVLIAYLS
| .. |     .|||.|....|.
akeags.....sDnitvvvvfld
subfamily_PPM1G2_pd Subfamily PPM1G2 11-329 2.2e-35 115.0 In-house 22-286 (287) alignment 
Range on Protein: 11-329
Range on HMM: 22-286/287.0
TAETNAGGRKHMEDYIAVSLSpkesLLSNPEMREQAFVGVFDGHGGKEAAKYARENLWSVIQDQSNFLtqdPQSVREAISNAYLQLHNTMEESraswvpN
.. .  | | .|||   .       ||.... .. |...|||||||...|||| ..| ..|. ...|     ....... .|.|.. . . .       .
gssamqGyrlnmeDahilene....lleksddkslalfavfDGhGGakvakyagkklikkiakkksfk...egaleqilkdafletDeellkd......e

KTGDlSTAGTTASTVIFRKNHIYVANVGDSTGIMGVRnprygepGepQiiPKLLTKDHKPEDPEEQENIRRLGGEVALSlkgvmrvvwermRVKSNgkke
|. | ..||.|| .|. .....||||.|||  .. ..       |  .   | |. ||||.. .|.. |   || |.|             ||  |    
klkd.esaGstavvvlikeeklyvanaGDsravlssk.......g..n..vkalsfDhkPqeesekkriiaagGfveln............rvngn....

idripfLSVARSLGDFWSYS---AQSGEYTVSPVPYVYDFPLDlNEQKFIVLASDGLWNVMSPSDVVNFISDFDSKGtsgsnnssdTNvQRDVVSALIKE
      |...|.||||   .    .. |  |  || |    || ... |.||| ||.|.|.. ..||...    ..|         ..   .... |...
......LalsralgDfefkknvkkkpeeqivtavPDvlvkkld.eddeflvLaCDGiWDvltnkevvdlvrerlvsg.........ak.ldeiieelldk

ALSRWSR-KKLQADNIAVLIAYL
.|.. |.   . .||..|.|  |
clapdssntgvGcDnmtvvivvl
subfamily_ILKAP_pd Subfamily ILKAP 15-327 1e-33 109.8 In-house 12-290 (293) alignment 
Range on Protein: 15-327
Range on HMM: 12-290/293.0
NAGGRKHMEDYIAVSLSPK-ESLLSNPEMREQAFVGVFDGHGGKEAAKYARENLWSVIQDQ---SNFLTQDpQSVREAISNAYLQLHNTMEESRASWVPn
  | |..|.|   .  . . .. |..  .   .. .|||||.|. |...| |.|  .| ..   |.. ... .... .. ... .  . . .  ..  | 
rkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsake.keikkclvdsfkktdeefLklaskakP.

ktgdLSTAGTTASTVIFRKNHIYVANVGDSTGIMGVRNPRYGEpgepqIIPKLLTKDHKPEdpeeqenirrlggevalslkgvmrVVWERMRVKSNGKK-
        |.|| .|.   | .||||.|||  ..  ...   .     |.   |||||.|                            ||.|..  | . 
....vWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdk.....iasvvLtkdhtpv........................kyeerkriqkaGgvv

EIDRI-PFLSVARSLGDFwSYSaqsgEYTVSPVPYVYDFPLDLNeQKFIVLASDGLWNVMSPSDVVNFISDF-DSKGTSGSNNSSDTNVQRDVVSALIKE
. .|.   | |.||.||   .     .  |. .| |    |. |  .|.||| ||||.|.| ..||.||..  ... .. . . .... ...|   .. .
rdgrvlGvlevsrsiGdg.rfk....rlGvistPdvkkceLten.dlfvvlaCdGLwkvfsadevvkfilkvledeeddrkikeeekkskeevrfevacn

ALSRWSRKKLQADNIAVLIA
 |.  . |.  .||..||. 
rlaseavkrgssdnvtvllv
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 16-282 7.7e-30 97.0 In-house 14-225 (255) alignment 
Range on Protein: 16-282
Range on HMM: 14-225/255.0
AGGRKHMEDYIAVSLSPKEsllsnpeMREQAFVGVFDGHGGKEAAKYARENLWSVIQDQSNFLTQDPQsvrEAISNAYLQLHNTMeesraswvpNKTGdl
 | |  ||| ...  | ..         .. .. .||||||..|||.| |.|  ....  .    .|.   ... .|| ...  .         .. .  
iGrrptmedelviyGsfrd.......ksdedyyalfdGhgGraaakfaseelykilaelldlnnanPv...kslkkaykeistqi.........serp..

STAGTTASTVIFRKNHIYVANVGDSTGIMGvrnprygepgEPQIIPKLLTKDHKPEDPEEQENIRRLGGEVALSlkgvmrvvwermrV---KSNGKkeid
   |||| .|.. ....|.||||||  ...          . . . | |. |||| ...|.. |..||| |  .             |   . ||.    
kfiGttaasvliiedkvyianvGdsrvvlc..........qkdgtakrlsldhkPseeseekriselGGtvvst.............vvtsrvnGt....

ripfLSVARSLGDFWSysaqsgEYTVSPVPYVYDFPLDLNEQKFIVLASDGLWNVMSPSDVVNFISDFDS
    |.|.|.||| .       |  | | |.. .     ...||..|| ||.|...|  . |. . .  .
....lavsralGdsfl......ePfvvpdPdlsqsleiskkdkflilacdGiwdlisdeeaveivagisd
subfamily_PPM1L_pd Subfamily PPM1L 16-279 3.5e-26 85.0 In-house 13-234 (269) alignment 
Range on Protein: 16-279
Range on HMM: 13-234/269.0
AGGRKHMEDYIAVSLSPKESllsnpemREQAFVGVFDGHGGKEAAKYARENLWSVIQDQSNFLTQDpQSVREAISNAYLQLHNTMEESrASWVPNKTGDL
 | |..||| . .    |..        .. |..|||||||. ||..|.. |   |...   | .| .   | |. . |  .. .       . . .   
lGrrprmedrfeieediknk.......tgesffavfdGhGGefaaefakdvlvkaiknklieldad.kentepinfsklltdeilsvd.ekllekakrae

STAGTTASTVIFRKNHIYVANVGDSTGIMgvrnprYGEPGepQIIPklLTKDHKPEDPEEQENIRRLGGEVAlsLKGVMRVvwermrvKsnGkkeidrip
 .|||||   . ..... ||||||| |..      | . |  . ||  |. ||||....|.  |.. || .|  ..|| ||       .  |        
diaGttalialvqesdlivanvGdsrGvl......ydkrG..kaip..lsfdhkpqqvkerkrikkaGGfia..frGvwrv.......a..G........

FLSVARSLGDfwsYSAQSgEYTVSPVPYVYDFPLDLNEQKFIVLASDGLWNVMSPSDVVNFISD
 |...|.|||   |  .  .  | . | .  | ||  . .|..|||||||. .|  . |.|| .
vlatsralGd...yplkd.knlviadpdiltfdlddhkpeflilasdGlwdtfsneeavrfike
PPM_PTC7_SpoIIE 16-280 8.9e-25 80.8 In-house 9-208 (230) alignment 
Range on Protein: 16-280
Range on HMM: 9-208/230.0
AGGRKHMEDYIAVSLSPKESllsnPEMREQAFVGVFDGHGGKEaaKYARENLWSVIQDQSnFLTQDpqSVREAISNAYLQLHNTMEESraswvpnktgdL
 | ||.|||  ..      |    .. |  ..||..||||| .  ..|.. |..... .. | . .   . |......|.|.  .|..            
qgarksmedahispanseks....sggrlalvvgdvdGhGgra..alamgllrtalrela.fagle..kpeeilrrlnlalaadlede...........p

STAGTTASTVIFRKNH--IYVANVGDSTGIMGVRNPRygepgepqiipklltkdhkpedpeeqeNIRRLGGEVALSlK----GvmRVVWErmrvksngkk
|. |.||. .... ..  .||||.|||  ..   ...                            ..|...  ..|      |  ||...          
sssgaTavvalidpstgklyvanaGdsppllvrddgg...........................ererivagglps.lGilpg..rvfgv..........

eidripfLSVARSLGDFWSYSaqsGEYTVSPVPYvYDFPLDLNEQKFIVLASDGLWNVMSPSDVVNFISDF
       |.|... ||.. .     .  |.. |.  .  .. ....|..|||||||.|.|| ..| .. | 
.......lavslapGdlllly...tDGvveaepd.tsdgelfgkdeflilasdglwdvlspqelvdlvrde
subfamily_PPM1K_pd Subfamily PPM1K 45-279 1.2e-22 73.3 In-house 31-227 (263) alignment 
Range on Protein: 45-279
Range on HMM: 31-227/263.0
QAFVGVFDGHGGKEAAKYARENLWSVIQDqsnfLTQDPQSVREAISNAYLQLHNTMEESRASWVPNKtgDLSTAGTTASTVIFRK-NHIYVANVGDSTGI
  .|.|||||.|  ||... ..|  ....    | .  . ... . ||...|.. ..      |...  .| ..||||. ...|. ... .|..|||  |
llyvavfdGhaGsaaadfvhdklekilkr....llekekdleivlknafeeldkklkrylefsvaea..ellssGttatvsllrdGtelvlaslGdsrai

MGvRNpryGEpgepqiiPKLLTKDHKPEDPEEQENIRRLGGEVALSLKGVMRVvwermrvksNGKkeidripfLSVARSLGDFwsysaQSGEYTVSPVPY
.  ||   |.       .| ||.||.||  ||.| |.. || |. .  | ..|         ||.        |...|||||.     .  .| |   | 
lc.rn...Gk.......akkltrdhdPeleeekerikaagGsvewnslgkplv.........ngr........lamtrslGdl.....dlkryGviatPe

VYDFPLDLNEQKFIVLASDGLWNVMSPSDVVNFISD
   . .| ... |.|| .||. .|..  .. .... 
tkslkvdhaadsflvlitdgisfvvnsqelcdlvrl
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 47-230 5.7e-18 58.4 In-house 22-187 (292) alignment 
Range on Protein: 47-230
Range on HMM: 22-187/292.0
F-VGVFDGHG--GKEAAKYARENLWSVIQDqsnfLTQDPQSVREAISNAYLQLHNTMEESRASwvpnktgDLSTAGTTASTVIFRKN-HIYVANVGDSTG
|   |.||||  |.. |..| ..|   . .    ||.. | . ||. .  |..   .... .            |.|..   . | .  ...||||||  
flaavldGhGvnGdkvaqlaedtlevelle....ltrqlqelsealllrildiaakldkltid.......aresattavvcarvrddralilanvGdsra

IMGvrnpRYGEPGEPQIIPklLTKDHKPEDPEEQENIRRLGGEVA------LSLKGVMRVvWERMrvKSNGKkeidripfLSVARSLGDFWSYS
..|    |     . ..||  |..|||||||.|.. |.| || |          .|  || | |   . .|         |...|.||||  . 
llg....rclggsdyeliP..lsrdhkPedPderarilraGGrveptrvrgwgfrGtarv.wrrr..qqeGd........lalsralGdfhlfe
subfamily_KAPP-like_pd Subfamily KAPP-like 17-308 4.4e-17 55.0 In-house 7-258 (266) alignment 
Range on Protein: 17-308
Range on HMM: 7-258/266.0
GGRKHMED-YIAVSLSPKESLLSNpeMREQAFVGVFDGHGGKEAAKYARENLWSVIQDQSNFlTQDPqSVREAISNAYLQLHNTMEEsraswVPNKTGDL
|   .||| ..|.    ||  |||    . |. .||||| || ||. |.. .  ..... .  |..     . | .    |.|...|     | .|  | 
gcstemedvslaiypllkekklsn..csnialfavfdGhaGkGaadaakklfpkelekllks.tkqd.dGGdniydqskllenafke.....vdaklkdf

STAGTTASTV-IFR---KNHIYVANVGDSTGIMGVRNprygepgePQIipkLLTKDHKPEDPEEQENIRRLGgeVALslkgvmrvvwermrvkSNGKkei
   |.||. . ...   . .. |||||||. ..   |          .    |.|||| .||||.  |.  |  ..|                |...   
eyeGatatlalvwsdGqqrylqvanvGdssaflsrGn........esl...elskdhkakdpeekqrikddG..itl................sdnq...

DRIPFLSVARSLGDFWSYSAQSGeytVSPVPYVYDFPLDLNEQKFIVLASDGLWNVMSPSDVVNFISD-FDSKGTSGSNnsSDTNVQRDVVSALIKEA
 ||  | |.|.||| .    . |   ..  ||| .  |    .||...||||||.|.|  | .. ..  .| . |. .   ... ..  . |.. |. 
trinGlavsralGdhfikelniG...lisepyvsnrilltpfdkflivasdGlwdvisGkdaiekvkslydqqatedkm..asslletaiqsikakdn
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 18-308 2.7e-15 49.0 In-house 7-268 (276) alignment 
Range on Protein: 18-308
Range on HMM: 7-268/276.0
GRKHMED-YIAVSLSPKESLLSNpeMREQAFVGVFDGHGGKEAAKYARENLWSVIQDQS---N-FLTQDPQSvREAISNAYLQLHNTMEEsraswVPNKT
   .||| ..|.    .|  |||    . |. .||||| || ||. |.. .  ...      |  ||.. .   . | .    | . ..|     | .| 
cstemedvslaiyplldekdlsn..csnialfavfdGhaGkGaadaakklfpkelekllksgnysltkqddG.Gdniydqskllldlfke.....vdakl

GDLSTAGTTAST-VIFRKN---------HIYVANVGDSTGIMGVRNprygepgePQIipkLLTKDHKPEDPEEQENIRRLGgeVALslkgvmrvvwermr
 |    |.||.  .....          .. |||||||. ..   |          .    |.|||| .||||.. |.  |  ..|              
kdfeyeGatatlalvwsdGeeqqqqqqrylqvanvGdssaflsrGn........esl...elskdhkatdpeekqrikddG..itl..............

vkSNGKkeiDRIPFLSVARSLGDFWSYSAQSGeytVSPVPYVYDFPLDLNEQKFIVLASDGLWNVMSPSDVVNFISD-FDSKGTSGSNnsSDTNVQRDVV
  |...    ||  | |.|.||| .    . |   ..  ||| .  |    .||...||||||.|.|  | .. ..  .| . |. .   ... ..  . 
..sdnq...trinGlavsralGdhfikelniG...lisepyvsnrilltpfdkflivasdGlwdvisGkdaiekvkslydqqatedkm..asslletaiq

SALIKEA
|.. |. 
sikakdn
subfamily_PDP_pd Subfamily PDP 21-180 4.9e-12 38.7 In-house 46-208 (398) alignment 
Range on Protein: 21-180
Range on HMM: 46-208/398.0
HMEDYIAVSLSPKESLLSNP-EMREQA----FVGVFDGHGGKEAAKYARENLWSVIQDQSNFLTQDPQSVREAISNAYLQLHNTMEESRASWVPNKTG--
.. .|.|.|| .|. | .   ......    .. . . . .. . . .. .| .. .   . |  . ..|.||...|.|.| . . .   . ...|.   
rLlkyvaasllkkqvleeaekalesgkallkllkkskhkldvvsdeakklslselskylqelleaevekvkealkkaFlklDkdistealkklkekslre

--DLSTAGTTASTVIFRKNHIYVANVGDSTGIMGVRNPRygepGEpqIIPKLLTKDHKPEDPEEQENIR
  . ...|..| ..  ......|||.||.  ..||....    |.     . |.||.  . .|| | |.
allvalsGacallaliegtelhvAntGDcravlgvqeee....gs..weavkLskdqtadneeEveRik
subfamily_PPM1G_pd Subfamily PPM1G 117-188 2.9e-11 36.0 In-house 295-355 (473) alignment 
Range on Protein: 117-188
Range on HMM: 295-355/473.0
TAGTTASTVIFRKNHIYVANVGDSTGIMGVRnprygepgepqIIPKLLTKDHKPEDPEEQENIRRLGGEVAL
 .||||  .. ......|||.|||  ..                   |  ||||||..|.| |.. ||.|  
dsGttAvvaLlkekklivAnaGDsRcvlsrn...........GkAldlslDHkPeDevEleRiekAGGkvde
PP2C_SIG_SM00331 45-327 4e-11 35.9 In-house 30-215 (217) alignment 
Range on Protein: 45-327
Range on HMM: 30-215/217.0
QAFVGVFDGHG-GKEAAKYArENLWSVIQDQSNFLTQDPQSVREAISNAYLQlhntmeesraswvpnktGDLSTAGTTASTVI--FRKNHIYVANVGDST
. .. |.||.| |..|| .. . | .... ...  .  .| ...... .| .                  . .  ..|.   .  |.......||.||| 
rlllvvaDgmGkGlaAaaas.sqlrtalrellsegeelsqalkrlnraiyee.................keekgmfaTlllalydfssgklsyanaGdsr

GIMGVrnprygE------PGEpqiipklltkdhkpedpeeqenirrlggevalslkgvmrvvwermrvksngkkeidripflsvarslgdfWSY------
 ..        .        .                                                                      ..       
pyllr......dgklveilkd......................................................................vegaplGle

---SaqsgeytvspvpyVYDFPLDLNEQKFIVLASDGLWNVMSPSDvvnfISDFDSKGTSGSN-NSSDTNVQRDVVSALIKEALSRWSrkklqADNIAVL
   |             |.   |.|..  ...|..|||....|. .    . ... ..   .. .|..  .... |  |. .|  .        |.|.|.
pevs.............vdirelelekgdllllytDGltearsekg....faeerleeiledlvdseaqelaqkiveellelakgsng.....eDdiTvv

IA
. 
vv
subfamily_PPM1G_pd Subfamily PPM1G 9-101 2.7e-10 32.9 In-house 20-100 (473) alignment 
Range on Protein: 9-101
Range on HMM: 20-100/473.0
SVTAETNAGGRKHMEDYIAVSLSPKEsllsnpemrEQAFVGVFDGHGGKEAAKYARENLWSVIQDQSNFLTQDpqsVREAISNAYLQLHNTME
|..| .  | |. .|| . . .  .|         . .. .|.||||||| |||  ..|  ....|  .   |   |..|...|.|.| ....
sygasamqGwrvsqEDahncitdlde.........dtslfavyDGHGGkevakyvakklpdllkaqkgykegd...vekaleeaflalDeklk
subfamily_PPM1G_pd Subfamily PPM1G 217-309 8.7e-10 31.2 In-house 363-449 (473) alignment 
Range on Protein: 217-309
Range on HMM: 363-449/473.0
LSVARSLGDfWSYSAQ----SGEYTVSPVPYVYDFPLDlNEQKFIVLASDGLWNVMSPSDVVNFISDFDSKGTSGsnnssdtnVQRDVVSALIKEAL
| ..| ||| ..|  .      |  .| .| .    |  .|..|.|||.||.||||.  .||.|. .  .||.          |  ..| .|. ..|
LnlsRAlGD.haYkkneeLplkeqmisAlPDikvltlt.eedeFlvlAcDGiWnvmesqevvdfvraklkkgees........vlseiveeLlDacl
subfamily_PDP_pd Subfamily PDP 242-314 1.4e-09 30.6 In-house 274-346 (398) alignment 
Range on Protein: 242-314
Range on HMM: 274-346/398.0
PYVYDFPLDlNEQKFIVLASDGLWNVMSPSDVVNFISDFDSKGTSGSNN-SSDTNVQRDVVSALIKEALSRWSR
| |   .|  ...||.|||.||||...|...||. .... .| .. ..  .......   |.   ||. .  .|
Pevtshklr.endkFLvlatDGLwdllsneevvslVgehlakkkekepvkveeakltlkqvveelkerkrklkr
Subfamily Dicty-PPM1L-like 42-140 1.7e-09 29.9 In-house 34-137 (305) alignment 
Range on Protein: 42-140
Range on HMM: 34-137/305.0
MREQAFVGVFDGHGGKEAAKYARENLWSVIQD---------QSNFLTQDpQSVREAISNAYLQLHNTMEESRASwvPNKTGDlSTAGTTASTVIFRKNHI
 .|. . ||||||.|. ||.|.. .|  ..            .. |  | ..  |||..|.|.  . . .|  |   || .  .|   ....||. .. .
sqelslfGvfdGhnGdiaaeyvkkklveivnkyvkenkvGysaknlnvd.dlpleaiksaslstdkssldsaes..dnkkaG.ttlngssasvilerert

YVANVGDS
 |.. .|.
ivstasdt
PPM_PTC7_motif 258-285 2.5e-08 27.3 In-house 1-29 (51) alignment 
Range on Protein: 258-285
Range on HMM: 1-29/51.0
VLASDGLWNVMSPSDVVNFISDFDS-KGT
.|||||||.|.|. ..|... |. | ||.
iLAsDGLWDvlsdqeavdlvrdqlskkgl
subfamily_PP2D1_pd Subfamily PP2D1 132-282 4.1e-08 25.3 In-house 190-307 (492) alignment 
Range on Protein: 132-282
Range on HMM: 190-307/492.0
IYVANVGDSTGIMgVRNpryGEPgepqiipKLLTKDHKPEDPEEQENIRRLGGEVALSLKgVMRVvwermrvksNGKkeidripfLSVARSLGDfwsYSA
.|.||.|.   .. .|.   |.        . ||..| |....| . ... |. |  | | . .|         ||         |.. | ||    |  
lyianaGnvqAvL.cre...Gka.......iiLtreHtprnkkERtRvekagsvvvksek.nglv.........nGi........ldttRGLGn...yGd

QSGEYTVSPVPYVYDFPLDlNEQKFIVLASDGLWNVMSPSDVVNFISDFDS
.  . .| | |..   .|| ....|.|||| |||.|.|  .|.. . ..  
pkLkksvipePkttsvkld.eaaqflvlAsnGlWevlseeevlsLvkqtla
subfamily_TAB1_pd Subfamily TAB1 118-266 9.3e-07 20.9 In-house 129-258 (333) alignment 
Range on Protein: 118-266
Range on HMM: 129-258/333.0
AGTTASTVIFRKNHIYVANVGDSTGIMGVRNPrygepgEPQIipKLLTKDHKPEDPEEQENIRRLGgevaLSLKGVMRVvwERMrvksNGKKEIDRIPFL
 ||||  ..   |..||||||||  ..  |..      . ..  | | .||. . ..| . ...||    |  . . |.  .|.     .|..  .|  .
gGttAvvalifnnkLyVaNvGdsrAllvkrke......sekv..kqLsvdHttdNedEllRlkdLG....ldieqikrn..krl....gskentRsiGdy

SVARSLGDFWSYSAQSGEYTVSPVPYVYDFPLDlNEQKFIVLASDGLWN
.|     |.  .|. .||  ..    .. .|.| . ..|.|| |||. .
kvkkgykdvdilssakgePviaePdiqgaypid.dityflvlmSdGvyk
DUF3306 Protein of unknown function (DUF3306) 308-380 6.1e-06 13.4 Pfam-A 2-58 (115) alignment 
Range on Protein: 308-380
Range on HMM: 2-58/115.0
ALSRWSRKKLQAdniavliaylseeEEEEETGAPPLFDVVSSANEATEVGSKSAVSCSEEADSRQCVaipSIP
 ||||||.||.|             ...||. ...  .... .....|  .... . .|..| . .    ..|
flsRWsrRklaa.............kaaeepaeeaeeeeseeeaaeaeaaaeeeeeeaeledeelle...tlp
Subfamily Dicty-PPM1L-like 253-329 8.5e-06 17.8 In-house 235-303 (305) alignment 
Range on Protein: 253-329
Range on HMM: 235-303/305.0
EQKFIVLASDGLWNVMSPSDVVNFISDFDSKGTSGSNNSSDTNvqrDVVSALIKEALSRWSRKklqadNIAVLIAYL
. .|.||| ||||.|.|  |||... .   . .|. .   | |   .. .   .||..| |.      || ..|  |
nDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfn...eisrviveeavkrgsgD.....nitlviikl
PP2C_2 Protein phosphatase 2C 49-155 9.4e-06 18.1 Pfam-A 28-134 (212) alignment 
Range on Protein: 49-155
Range on HMM: 28-134/212.0
GVFDGHGGKEA----AKYARENLWSVIQDQSNFLTQD-PQSVREAISNAYLQLHNTMEESRASwvpnKTgDLSTAGTTASTVIFRKNHIYVANVGDSTGI
 | ||.|  .     |..| |.. . .... .   ..  . ....|.|..|.. .  .|  |.    .  .|.  .|| . .......|.....||.  .
aVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaq....qe.elkdyatTlllavitpgeivffqiGDgaiv

MGVRNPRYGEPG
.  |. ..  .|
vrdrdgevqllg
PP2C_2 Protein phosphatase 2C 49-155 9.4e-06 18.1 In-house 28-134 (212) alignment 
Range on Protein: 49-155
Range on HMM: 28-134/212.0
GVFDGHGGKEA----AKYARENLWSVIQDQSNFLTQD-PQSVREAISNAYLQLHNTMEESRASwvpnKTgDLSTAGTTASTVIFRKNHIYVANVGDSTGI
 | ||.|  .     |..| |.. . .... .   ..  . ....|.|..|.. .  .|  |.    .  .|.  .|| . .......|.....||.  .
aVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaq....qe.elkdyatTlllavitpgeivffqiGDgaiv

MGVRNPRYGEPG
.  |. ..  .|
vrdrdgevqllg