Gene PPM1D-3 in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1D
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP210_AA protein Get Run
AqueP210_AA_0-124 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1D_pd Subfamily PPM1D 1-124 2e-38 125.2 In-house 40-168 (309) alignment 
Range on Protein: 1-124
Range on HMM: 40-168/309.0
VFDGHGGRGAAQYAKSRLFPLLETS----CSHEESVKEAMRSSFLKIHSEMSSVRESWTSTREGYLSTSGTTATVVVLQPTKLYIGNVGDSAGILAVRGP
|||||||. ||..|...|.  ..       |..|.| ||.|..||..|..|  ..|.|. |..|.|||.||||.||... .|||...||||| .|.|. |
vfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktksgllstaGttasvviirreklyvahvGDsaivlgvkep

-FGKLFPKPITANHRPNNYKECQNIEQLG
   || .|..| .|.|.. .| ..||.||
kekklrakeltkdHkPespeekerieelG
PPM_PTC7 1-124 6.1e-26 84.4 In-house 39-156 (259) alignment 
Range on Protein: 1-124
Range on HMM: 39-156/259.0
VFDGHGGRGAAQYAKSRLFPLLETSCSHEES--VKEAMRSSFLKIHSEMSSVReswTSTREgYLSTSGTTATVVVLQPTKLYIGNVGDSAGILAVRGPFG
|||||||| ||.||...| . |. . | ||.  ...|.| |||... .... .   .....   ||||.||.|......|||. |||||  .|. .| . 
vfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelks...seant.epstsGstAvvalitgsklyvAnvGDSravLcrsgnav

klfpKPITANHRPNNYKECQNIEQLG
    |. |  |.|.| .| . ||..|
....kqltedHkpsnedEreRiegag
PP2Cc_SM00332 1-124 8.1e-26 84.0 In-house 45-164 (274) alignment 
Range on Protein: 1-124
Range on HMM: 45-164/274.0
VFDGHGGRGAAQYAKSRLFPLLETSCSHEES-----VKEAMRSSFLKIHSEMSSVRESWTSTRegylSTSGTTATVVVLQPTKLYIGNVGDSAGILAVRG
|||||||  .|......|.  |. ... ...     |.||....||....|.    .|.   .    ..||.||.|..|.  .||. |||||  .|.  |
vfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskelen....alsGstavvallkkedlyvanvGDSravlcrng

PfgklfPKPITANHRPNNYKECQNIEQLG
       .... .|.|.. .| . |.. |
k.....avqlsvdhkpedederkRikkag
PP2C Protein phosphatase 2C 1-124 1.2e-25 83.5 Pfam-A 39-155 (255) alignment 
Range on Protein: 1-124
Range on HMM: 39-155/255.0
VFDGHGGRGAAQYAKSRLFPLLETSCSHEES--VKEAMRSSFLKiHSEMSSVReswTSTREgYLSTSGTTATVVVLQPTKLYIGNVGDSAGILAVRGPFG
|||||||| ||.||...| ..|. . | .|.  |..|.|.|||. . ...  .   .....   |.||.||.|......|||. |||||  .|. .. . 
vfdghggreaakyarehleeilkeqksflelekvekalrksfla.dtdeelks...skant.epsksGstavvalirgkklyvAnvGDSravLcrkdnak

klfpKPITANHRPNNYKECQNIEQLG
    | .|  |.|.. .| . ||..|
....keltedHkpsdedEreRIeeag
PP2C Protein phosphatase 2C 1-124 1.2e-25 83.5 In-house 39-155 (255) alignment 
Range on Protein: 1-124
Range on HMM: 39-155/255.0
VFDGHGGRGAAQYAKSRLFPLLETSCSHEES--VKEAMRSSFLKiHSEMSSVReswTSTREgYLSTSGTTATVVVLQPTKLYIGNVGDSAGILAVRGPFG
|||||||| ||.||...| ..|. . | .|.  |..|.|.|||. . ...  .   .....   |.||.||.|......|||. |||||  .|. .. . 
vfdghggreaakyarehleeilkeqksflelekvekalrksfla.dtdeelks...skant.epsksGstavvalirgkklyvAnvGDSravLcrkdnak

klfpKPITANHRPNNYKECQNIEQLG
    | .|  |.|.. .| . ||..|
....keltedHkpsdedEreRIeeag
0034914 PP2C-like 1-124 3.1e-24 78.5 In-house 57-178 (295) alignment 
Range on Protein: 1-124
Range on HMM: 57-178/295.0
VFDGHGGRGAAQYAKSRLFPLLET--------SCSHEESVKEAMRSSFLKIHSEMSSVRESwtstrEGYLSTSGTTATVVVLQPTKLYIGNVGDSAGILA
|||||||  ||..|...|. ||          ... .|...||.|..||... |. .  ..     . .|..|||||.|......|||..|||||  .| 
vfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellelall.....rpelagsGtTavvalirgnklyvanvGDSravll

VRGpfgklFPKPITANHRPNNYKECQNIEQLG
 .|      ....|  |.|.|. | . |...|
rng.....elvqltvdhkpvnelererilsag
subfamily_PPM1G2_pd Subfamily PPM1G2 1-122 4.8e-21 68.0 In-house 57-167 (287) alignment 
Range on Protein: 1-122
Range on HMM: 57-167/287.0
VFDGHGGRGAAQYAKSRLFPLLETSCSH-EESVKEAMRSSFLKIHSEMSSVreswTSTREgylSTSGTTATVVVLQPTKLYIGNVGDSAGILAVRGPfgk
|||||||. .|.|| ..|   ...  |. |........ .||.. .|. .     .....   ...|.||.||... .|||..|.|||  .|...|    
vfDGhGGakvakyagkklikkiakkksfkegaleqilkdafletDeellkd....eklkd...esaGstavvvlikeeklyvanaGDsravlsskgn...

lfPKPITANHRPNNYKECQNIEQ
   | .. .|.|.. .| . |..
..vkalsfDhkPqeesekkriia
subfamily_PPM1A_pd Subfamily PPM1A 1-124 6.2e-20 64.7 In-house 47-169 (282) alignment 
Range on Protein: 1-124
Range on HMM: 47-169/282.0
VFDGHGGRGAAQYAKSRLFPLLET---------SCSHEESVKEAMRSSFLKIHSEMSSVRESWTSTregylSTSGTTATVVVLQPTKLYIGNVGDSAGIL
|||||.|. .|.|.|. |   . .         . |....||||.|..||........  .. ...       ||.||..|......|.| |.||| ..|
vfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairelstdlkta.....dksGsTavtvlvsekhliianlGDsRavl

AVRGpfgklFPKPITANHRPNNYKECQNIEQLG
.  |       .  |  |.|.. || . ||| |
crng.....kaaflteDHkpsrpkEkkRieqAG
subfamily_PPM1E_pd Subfamily PPM1E 1-124 5.3e-19 61.4 In-house 45-156 (265) alignment 
Range on Protein: 1-124
Range on HMM: 45-156/265.0
VFDGHGGRGAAQYAKSRLFPLLETSCSHEESVKEAMRSSFLKIHSEMSSvreswTSTREGYlsTSGTTATVVVLQPTKLYIGNVGDSAGILAVRGPFGKL
|||||||  ||.||...|. ||    . .|. .||....| .. ... .     ...||..  .||.|| ||...  .||.. .||| ..|   | . .|
vfDGHgGveaakyaaahlhellvrqeklkedpaealkeafkltDerflq.....kaerekl..ksGstavvvliekdqlyvaWlGDsqallvrkgeavql

fpkpiTANHRPNNYKECQNIEQLG
     .  |.|.. .| . ||..|
.....mkpHkPeredEkkRieeag
subfamily_PPM1K_pd Subfamily PPM1K 1-122 7.1e-18 57.7 In-house 36-151 (263) alignment 
Range on Protein: 1-122
Range on HMM: 36-151/263.0
VFDGHGGRGAAQYAKSRLFPLLETSCSHEESVKEAMRSSFLKIHSEMSSVRESWTSTRegYLSTSGTTATVVVLQ-PTKLYIGNVGDSAGILAVRGPfgk
|||||.|  ||... ..|   |..   .|. ... .. .|.... ....  |   . .   | .|||||||..|.  |.| . ..|||  ||  .|    
vfdGhaGsaaadfvhdklekilkrllekekdleivlknafeeldkklkrylefsvaea..ellssGttatvsllrdGtelvlaslGdsrailcrnGk...

lfPKPITANHRPNNYKECQNIEQ
  .| .| .| |.  .| . | .
..akkltrdhdPeleeekerika
0049733 PP2C-like 1-123 8.4e-18 57.8 In-house 31-145 (235) alignment 
Range on Protein: 1-123
Range on HMM: 31-145/235.0
VFDGHGGRGAAQYAKSRLFPLLETS--CSHEESVKEAMRSSFLKIHSEMSSVRESWTstregYLSTSGTTATVVVLQPTKLYIGNVGDSAGILAVRGPfg
|.|||||  |...| ..|. .|       ......||.|..||...... .  ...       |...||||.|..|.. |||. |||||  .|  .|   
vaDGhgghaagevasellvetllelllelllldleealrkaflaaneallelalasp.....elagmgtTavvalldggklyvanvGDsrayllrdgk..

klfPKPITANHRPNNYKECQNIEQL
     ..| .|.|.|  | | |...
...lvqltedhspvnelerqriita
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 1-124 1e-15 50.7 In-house 41-150 (255) alignment 
Range on Protein: 1-124
Range on HMM: 41-150/255.0
VFDGHGGRGAAQYAKSRLFPLLETSCSHEES-VKEAMRSSFLKIHSEMssvreswtSTREgylSTSGTTATVVVLQPTKLYIGNVGDSAGILAVRgpfgK
.||||||| ||..|  .|. .|.     ...  ..... .. .|.  .        | |       ||||..|..   | || |||||  .|. .    .
lfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeistqi........serp...kfiGttaasvliiedkvyianvGdsrvvlcqk....d

LFPKPITANHRPNNYKECQNIEQLG
   | .. .|.|.. .| . |..||
gtakrlsldhkPseeseekriselG
subfamily_PPM1L_pd Subfamily PPM1L 1-124 6.1e-15 48.2 In-house 40-161 (269) alignment 
Range on Protein: 1-124
Range on HMM: 40-161/269.0
VFDGHGGRGAAQYAKSRLFPLLETSCSHEESVKEAMR-SSFLKI-HSEMSSVRESWTSTREGYLSTSGTTATVVVLQPTKLYIGNVGDSAGILAVRGpfG
|||||||  ||..||..|   . .   . .. ||     .| |.   |. || |    . .    ..|||| . ..| ..| . ||||| |.|  .   |
vfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakraediaGttalialvqesdlivanvGdsrGvlydkr..G

KLFpkPITANHRPNNYKECQNIEQLG
|    |.. .|.|.. || . |.. |
kai..plsfdhkpqqvkerkrikkaG
subfamily_ILKAP_pd Subfamily ILKAP 1-123 1e-13 44.1 In-house 48-172 (293) alignment 
Range on Protein: 1-123
Range on HMM: 48-172/293.0
VFDGHGGRGAAQYAKSRLFPLLETS------CSHEESVKEAMRSSFLKIHSEMSSVRESWTSTregylSTSGTTATVVVLQPTKLYIGNVGDSAGILAVR
|||||.|. |...|...|   . .        ..|...| ..  || |  .|. .  .. . .        |.|||||.     ||..|.|||  .|. .
vfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefLklaskakPv.....WkdGstatvvlvldnvlyvanlGdskavlvrk

GPFGK-LFPKPITANHRPNNYKECQNIEQL
 . |. .   ..| .| | .|.| . |.. 
keegdkiasvvLtkdhtpvkyeerkriqka
PPM_PTC7_SpoIIE 1-92 1.5e-13 44.1 In-house 39-120 (230) alignment 
Range on Protein: 1-92
Range on HMM: 39-120/230.0
VFDGHGGRGaaQYAKSRLFPLLETSCSHEES-VKEAMRSSFLKIHSEMSSVreswtstregyLSTSGTTATVVVLQPTK--LYIGNVGDSAGILA
..||||||   ..| ..|  .|.. . .. . ..|..| ..|... .. .             |.||.||.|....|..  ||. |.|||  .| 
dvdGhGgra..alamgllrtalrelafaglekpeeilrrlnlalaadlede...........psssgaTavvalidpstgklyvanaGdsppllv
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 1-123 2.4e-13 43.3 In-house 26-144 (292) alignment 
Range on Protein: 1-123
Range on HMM: 26-144/292.0
VFDGHG--GRGAAQYAKSRLFPLLETSCSHEESVKEAMRSSFLkihSEMSSVRESWTSTREgylsTSGTTATVVVLQPT-KLYIGNVGDSAGILAVRGPF
|.||||  |.  ||.|...|   |  .  .   . ||.    |   .  . ....   .||     ..|...  . .   .|.. |||||  .|      
vldGhGvnGdkvaqlaedtlevelleltrqlqelsealllril...diaakldkltidare....sattavvcarvrddralilanvGdsrallgrclgg

GKLFPKPITANHRPNNYKECQNIEQL
 .  ..|.. .|.|..  | . | . 
sdyeliPlsrdhkPedPderarilra
subfamily_PDP_pd Subfamily PDP 28-121 3.9e-12 39.0 In-house 111-208 (398) alignment 
Range on Protein: 28-121
Range on HMM: 111-208/398.0
HEESVKEAMRSSFLKIHSEMS--SVRES-WTSTRE-GYLSTSGTTATVVVLQPTKLYIGNVGDSAGILAVRGPFGKLFPKPITANHRPNNYKECQNIE
. |.||||....|||. ...|  .....  .|.||    ..||..|.......|.|.. |.||.. .|.|. . |.   .......  .| .| . |.
evekvkealkkaFlklDkdistealkklkekslreallvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRik
subfamily_TAB1_pd Subfamily TAB1 65-124 4.4e-09 28.6 In-house 129-186 (333) alignment 
Range on Protein: 65-124
Range on HMM: 129-186/333.0
SGTTATVVVLQPTKLYIGNVGDSAGILAVRGPfgKLFPKPITANHRPNNYKECQNIEQLG
 |||| |...   |||. |||||  .|  | .  .   | .  .|  .| .| . ...||
gGttAvvalifnnkLyVaNvGdsrAllvkrke..sekvkqLsvdHttdNedEllRlkdLG
subfamily_PPM1G_pd Subfamily PPM1G 62-124 2.7e-08 26.3 In-house 293-350 (473) alignment 
Range on Protein: 62-124
Range on HMM: 293-350/473.0
LSTSGTTATVVVLQPTKLYIGNVGDSAGILAVRgpfGKLFpkPITANHRPNNYKECQNIEQLG
 . |||||.|..|.  ||.. |.|||  .|.     ||     .  .|.|.. .| . ||. |
GedsGttAvvaLlkekklivAnaGDsRcvlsrn...GkAl..dlslDHkPeDevEleRiekAG
subfamily_PPM1H_pd Subfamily PPM1H 23-110 3.4e-08 25.7 In-house 127-202 (404) alignment 
Range on Protein: 23-110
Range on HMM: 127-202/404.0
ETSCSHEESVKEAMRSSFLKIHSEMSSVreswtstREGYLSTSGTTATVVVLQPTKLYIGNVGDSAGILAVRGPFgklfpKPITANHR
| . |.|| |. |. |.||.. . ..         || |  . | || |...   |||. | |||  ||  ..       .|. |.. 
ekeiskeeLviGalesaflemDeqiare.......reayrikGGCtalvalvllgklYvanaGDsRailvrkdei.....iplsadft
subfamily_KAPP-like_pd Subfamily KAPP-like 1-122 6.8e-08 24.8 In-house 39-156 (266) alignment 
Range on Protein: 1-122
Range on HMM: 39-156/266.0
VFDGHGGRGAAQYAKsRLFP-LLETSCSHeesvkeAMRSSFLKIHSEMSSVRESWTSTREGYL---STSGTTATVVVLQ----PTKLYIGNVGDSAGILA
||||| |.|||. || .|||  ||           . .    .   ..| . |   .  .  |      |.|||....        | ..|||||. .|.
vfdGhaGkGaadaak.klfpkelekllks......tkqddGGdniydqskllenafkevdaklkdfeyeGatatlalvwsdGqqrylqvanvGdssafls

vRGPfGKLFpkpITANHRPNNYKECQNIEQ
 ||    |.   .. .|. .. .| | | .
.rGn.esle...lskdhkakdpeekqrikd
subfamily_PPM1G_pd Subfamily PPM1G 1-48 9.2e-07 21.2 In-house 52-100 (473) alignment 
Range on Protein: 1-48
Range on HMM: 52-100/473.0
VFDGHGGRGAAQYAKSRLFPLLETSCSH-EESVKEAMRSSFLKIHSEMS
|.|||||.  |.|  ..|  ||  . .. |. |..|.. .||.. ... 
vyDGHGGkevakyvakklpdllkaqkgykegdvekaleeaflalDeklk
PP2C_SIG_SM00331 1-91 1.2e-06 21.3 In-house 35-114 (217) alignment 
Range on Protein: 1-91
Range on HMM: 35-114/217.0
VFDGHGGRGAAQYAKSRLFPLLETSCSHEESVKEAMRSSFLKIHSEmssvreswtstreGYLSTSGTTATVVVL--QPTKLYIGNVGDSAGIL
|.||.|.  ||. | |.| ..|....|..|....|..     |..|                . ...|... ..  .  ||.. |.|||  .|
vaDgmGkGlaAaaassqlrtalrellsegeelsqalkrlnraiyee.............keekgmfaTlllalydfssgklsyanaGdsrpyl