Gene PPM1G in Amphimedon queenslandica

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1G
Protein sequence
ID Type Fasta BLAST phosphatome Note
AqueP212_AA protein Get Run
AqueP212_AA_22-526 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1G_pd Subfamily PPM1G 4-526 1.6e-203 670.0 In-house 1-472 (473) alignment 
Range on Protein: 4-526
Range on HMM: 1-472/473.0
FLTKPITDKTVTNGtigvSDKECQYGTATMQGWRENMEDVITVVTDFDDKCSFLGVFDGHGGKEVSVYCSRHLPGFLKASVGYQDGDVSRGFCEAYMNCD
.|.||...|. ...    | .|..||...|||||...||.....||.|...|...|.||||||||..|....||..|||..||..|||.....||....|
ylskpkvekesede....sneelsygasamqGwrvsqEDahncitdldedtslfavyDGHGGkevakyvakklpdllkaqkgykegdvekaleeaflalD

RKLLTEDALKEMKLINESEINEGEEELNGEESGDEVERLTEEAHMPLDKVLQACiedkkllkylinvanrnNGDGSNDDEISSSDGEGMASEEGLGGADN
.|| .|..|||.| |.|.| .|.||| ..||..||.|.|||||..|||..|...                 .||||...|.|....||.|||.. .....
eklkaeeslkelkeiaeaeededeeeeddeededeiellteeaeipldellkrl.................dgdgsekeelsqallegaasedeededed

IKETQRSRVYSQFIKELSVQYKPALNELQTMMGEDSSEGEEEEEEEEEEEGPGEGETEEEGKPviannvrkrkrcDESDEDLKDSKRLKEGRQEMGQALG
 .|...........|| ....|.| .. |....||.|| ||||||.||||....||||||...            ||..|. .|... .|...|..... 
eeeeeeekdteeeskeeekkakaakegkqekkeedesekeeeeeekeeeeedekgeteeeeee............dedeeeeedeeeaeeeeeeedeede

EGGGARGEGEGAKEEGDGDEYHDSEGHESGSTATVCLIKTNILYVANAGDSRCVLSSNgernhhhhhrylllGEAVDLSLDHKPIDPLERERIERAGGHI
|. ...||||.|||| ||.|.....|..||.||.|.|.|.. |.||||||||||||.|              |.|.||||||||.|. |.||||.|||..
eeeeedgegeeakeeldgseekeepGedsGttAvvaLlkekklivAnaGDsRcvlsrn..............GkAldlslDHkPeDevEleRiekAGGkv

DEDLRVNGGLNMSRAIGDHMYKTNETLPLKDQMISAYPDVHTRLLQTQDQFLVLASDGIWNCLDSQQVVDFINAKLLEVRNSkkdlVLSHICEELCDACL
|||.|||||||.|||.|||.||.||.||||.|||||.||.....|...|.|||||.|||||...||.||||..||| ....|    |||.|.|||.||||
dedgRvnGGLnlsRAlGDhaYkkneeLplkeqmisAlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgees....vlseiveeLlDacl

AEDIDNDGTGCDNMSIIITLLKP
|.|...||||||||..||.|||.
apdtsgDGtGCDnmtviivllkk
PP2Cc_SM00332 23-522 6.9e-78 254.8 In-house 7-274 (274) alignment 
Range on Protein: 23-522
Range on HMM: 7-274/274.0
DKECQYGTATMQGWRENMEDVITVVTDFD--DKCSFLGVFDGHGGKEVSVYCSRHLPGFLKASVGYQDGDVsrgfceaymncdrKLLTEDALKEMKLINE
.....||...|||||..|||.. ||.|..  .. .| ||||||||.||. ..|..|| .|| .  .....              .  .|.|||.  | ..
nlglsygkssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdel.............eddveealkkaflstd

SEINEGEEELNGEEsgdeverlteeahmpldkvlqaciedkkllkylinvanrnngdgsnddeisssdgegmaseeglggadniketqrsrvysqfikel
.||.| |. .. |.                                                                                      
eeileeeqskelen......................................................................................

svqykpalnelqtmmgedssegeeeeeeeeeeegpgegeteeegkpviannvrkrkrcdesdedlkdskrlkegrqemgqalgegggargegegakeegd
                                                                                                    
....................................................................................................

gdeyhdsegHESGSTATVCLIKTNILYVANAGDSRCVLSSNGErnhhhhhrylllgeAVDLSLDHKPIDPLERERIERAGGHIDEDlRVNGGLNMSRAIG
           |||||.|.|.| . |||||.||||.||..||.              ||.|| |||| |. ||.||..|||..  . ||||||..|||.|
.........alsGstavvallkkedlyvanvGDSravlcrngk..............avqlsvdhkpedederkRikkaggvvekg.rvngglavsrafG

DHMYKTNEtlPLKDQMISAYPDVHTRLLQTQDQFLVLASDGIWNCLDSQQVVDFINAKLLEVrnskkdlV--LSHICEELCDACLAEDidndGTGCDNMS
|| .|.|.  .||...|.| |||..  | ..|.||.|||||.|..|..|.|||.....| .        .    . ..||.|......    |...||..
dhflkknk..klkepyitaepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakg.......ktndpqeaaelldeeairr....ggseDniT

IIIT
....
vvvv
0034914 PP2C-like 26-526 2.2e-69 226.4 In-house 21-292 (295) alignment 
Range on Protein: 26-526
Range on HMM: 21-292/295.0
CQYGTATMQGWRENMEDVITVVTDF---DDKCSFLGVFDGHGGKEVSVYCSRHLPGFLKA-------SVGYQDGDVSRGFCEAYMNCDRKLLTEDALKem
 ..|.|..||.|...|| ..||...   .......|||||||| ... ..|..|. .|.        .  . . |. . . .|....|..||..  |.  
lrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellelallr..

klineseinegeeelngeesgdeverlteeahmpldkvlqaciedkkllkylinvanrnngdgsnddeisssdgegmaseeglggadniketqrsrvysq
                                                                                                    
....................................................................................................

fikelsvqykpalnelqtmmgedssegeeeeeeeeeeegpgegeteeegkpviannvrkrkrcdesdedlkdskrlkegrqemgqalgegggargegega
                                                                                                    
....................................................................................................

keegdgdeyhdSEGHESGSTATVCLIKTNILYVANAGDSRCVLSSNGernhhhhhrylllgEAVDLSLDHKPIDPLERERIERAGGHIDEDlRVNGGLNM
           .|   ||.||.|.||. | |||||.||||.||..||              |.| |. |||| ..||||||..||| .  . ||||.|..
...........pelagsGtTavvalirgnklyvanvGDSravllrng..............elvqltvdhkpvnelererilsaggavshg.rvngvlav

SRAIGDHMYKTNETLPLKDQMISAYPDVHTRLLQ-TQDQFLVLASDGIWNCLDSQQVVDFINAKLLEVRNskkdlvLSHICEELCDACLAedidndGTGC
.||.||. .|.. .|.|.....||.|||... |.  .|.||.|||||.|..|.....||...  | .  .      |....|||.|..||      . ..
tRalGdfdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgld......leeaaeeLvdlAla......rgsr

DNMSIIITLLKP
||.....  |..
DNiTvvvvrlng
subfamily_PPM1G2_pd Subfamily PPM1G2 328-524 3.7e-54 176.6 In-house 111-286 (287) alignment 
Range on Protein: 328-524
Range on HMM: 111-286/287.0
EGHESGSTATVCLIKTNILYVANAGDSRCVLSSNGErNHHhhhryLllgeavdlSLDHKPIDPLERERIERAGGHIDEDlRVNGGLNMSRAIGDHMYKTN
. ...||||.| ||| . ||||||||||.||||.|.  .      |        |.|||| .  |..||. ||| .. . |||| | .|||.||...|.|
kdesaGstavvvlikeeklyvanaGDsravlsskgn.vka.....l........sfDhkPqeesekkriiaagGfveln.rvngnLalsralgDfefkkn

ETLPLKDQMISAYPDVHTRLLQTQDQFLVLASDGIWNCLDSQQVVDFINAKLLEVRNskkdlvLSHICEELCDACLAEDIDNDGTGCDNMSIIITLL
.... ..|.. |.||| .. |. .| ||||| ||||..| ...|||... .| . ..      |..|.||| | |||.| .| | |||||...|  |
vkkkpeeqivtavPDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgak......ldeiieelldkclapdssntgvGcDnmtvvivvl
PP2C Protein phosphatase 2C 322-505 2.1e-50 164.7 Pfam-A 91-249 (255) alignment 
Range on Protein: 322-505
Range on HMM: 91-249/255.0
DEYHDsEGHESGSTATVCLIKTNILYVANAGDSRCVLSSNGERNhhhhhrylllgeaVDLSLDHKPIDPLERERIERAGGHIDEDLRVNGGLNMSRAIGD
.. .. |   |||||.|.||. . |||||.||||.||.....               . |. |||| |. ||||||.||| ...  |||| |..|||.||
skant.epsksGstavvalirgkklyvAnvGDSravLcrkdnak.............keltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGd

HMYKTNEtlplkDQMISAYPDVHTRLLQTQDQFLVLASDGIWNCLDSQQVVDFINAKLLEVRnskkdlVLSHICEELCDACLAE
. .| .|      |..|| |||... |. .|.||.|||||.|..|..|..||... .| . .       .. ..|||.| ..| 
felkpke.....eqlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkk......spmeaaeelvdeaiar
PP2C Protein phosphatase 2C 322-505 2.1e-50 164.7 In-house 91-249 (255) alignment 
Range on Protein: 322-505
Range on HMM: 91-249/255.0
DEYHDsEGHESGSTATVCLIKTNILYVANAGDSRCVLSSNGERNhhhhhrylllgeaVDLSLDHKPIDPLERERIERAGGHIDEDLRVNGGLNMSRAIGD
.. .. |   |||||.|.||. . |||||.||||.||.....               . |. |||| |. ||||||.||| ...  |||| |..|||.||
skant.epsksGstavvalirgkklyvAnvGDSravLcrkdnak.............keltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGd

HMYKTNEtlplkDQMISAYPDVHTRLLQTQDQFLVLASDGIWNCLDSQQVVDFINAKLLEVRnskkdlVLSHICEELCDACLAE
. .| .|      |..|| |||... |. .|.||.|||||.|..|..|..||... .| . .       .. ..|||.| ..| 
felkpke.....eqlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkk......spmeaaeelvdeaiar
PPM_PTC7 325-507 5e-49 160.1 In-house 95-255 (259) alignment 
Range on Protein: 325-507
Range on HMM: 95-255/259.0
HDsEGHESGSTATVCLIKTNILYVANAGDSRCVLSSNGERNhhhhhrylllgeaVDLSLDHKPIDPLERERIERAGGHID--EDLRVNGGLNMSRAIGDH
.. |   |||||.|.||  . |||||.||||.||...|.               . |. |||| .. ||||||.||| ..  .. |||| |..|||.||.
nt.epstsGstAvvalitgsklyvAnvGDSravLcrsgnav.............kqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdf

MYKTNETlplKDQMISAYPDVHTRLLQTQDQFLVLASDGIWNCLDSQQVVDFINAKLLEVrnskkdlVLSHICEELCDACLAEDI
 .| .||   . |..|| ||.... .. .|.||.|||||.|.....|..||...  | .         .. ..|.|.| ..| ..
elkpket...eeqlvsaePdisstkideedefliLasdGlwdvvsdqeavdlvrselskk.......dpmeaaeklvdeaiargs
subfamily_PPM1A_pd Subfamily PPM1A 326-524 3.3e-45 147.6 In-house 109-280 (282) alignment 
Range on Protein: 326-524
Range on HMM: 109-280/282.0
DSEGHESGSTATVCLIKTNILYVANAGDSRCVLSSNGernhhhhhrylllgEAVDLSLDHKPIDPLERERIERAGGHIDeDLRVNGGLNMSRAIGDHMYK
 .. ..|||||...|.. . |..||.|||| ||..||              .|. |. ||||..| |..||| |||..    |||| | .|||.||. ||
lktadksGsTavtvlvsekhliianlGDsRavlcrng..............kaaflteDHkpsrpkEkkRieqAGGsvv.vsRvnGaLAvsRalGDyeyk

TNETLPLKDQMISAYPDVHTRLLQTQDQFLVLASDGIWNCLDSQQVVDFINAKLLEVRNSKKdLvlshiCEELCDACLAEDidndgtGCDNMSIIITLL
..|... ..|..|| |.|..   ...|.|||||.||||  |....||.... .|    . .. .     ...| | .| ..        ||.|... |.
eeeekkaeeqlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadelee.v.....akalvdkalekg......srDNlsvlvvlf
0049733 PP2C-like 328-524 1.1e-35 116.2 In-house 88-233 (235) alignment 
Range on Protein: 328-524
Range on HMM: 88-233/235.0
EGHESGSTATVCLIKTNILYVANAGDSRCVLSSNGernhhhhhrylllgEAVDLSLDHKPIDPLERERIERAGGHIdedlRVNGGLNMSRAIGDHMYKtn
| . .|.||.|.|. .. |||||.||||..| ..|              ..| |. ||.| ..|||.||..|||..    ||.|.| ..||.||...|  
elagmgtTavvalldggklyvanvGDsrayllrdg..............klvqltedhspvnelerqriitaggav....rvpgrlaltralGdlllk..

etlplkdqmisayPDVHTRLLQTQDqFLVLASDGIWNCLDSQQVVDFINAkllevrnskkdLVLSHICEELCDACLAedidndGTGCDNMSIIITLL
             |||..  |. .| ||.|||||.|..|.....||...            | |....|.|....||      . |.||.....  |
.............pdvtvlelepgd.flllasDGlwdvlsdeeivdllrs...........ldleeaaerlvelala......rggrDNiTvvvvrl
subfamily_ILKAP_pd Subfamily ILKAP 332-487 2e-32 105.5 In-house 113-250 (293) alignment 
Range on Protein: 332-487
Range on HMM: 113-250/293.0
SGSTATVCLIKTNILYVANAGDSRCVLSSNGERNHHhhhrylllGEAVDLSLDHKPIDPLERERIERAGGHIDEDlRVNGGLNMSRAIGDHMYKTNEtlp
 ||||||.|.  |.||||| |||..||  . |  ..          .| |. ||.|..  ||.||..|||.. .. ||.| |..||.|||  .|.     
dGstatvvlvldnvlyvanlGdskavlvrkkeegdk........iasvvLtkdhtpvkyeerkriqkaGgvvrdg.rvlGvlevsrsiGdgrfkrlG...

lkdqmISAYPDVHTRLLQTQDQFLVLASDGIWNCLDSQQVVDFINAKLLEVrNSKK
     ... |||.   |.  |.|.||| ||.|. .. ..||.||.. | .  ....
.....vistPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvlede.eddr
subfamily_PPM1E_pd Subfamily PPM1E 327-526 1.7e-29 95.8 In-house 97-264 (265) alignment 
Range on Protein: 327-526
Range on HMM: 97-264/265.0
SEGHESGSTATVCLIKTNILYVANAGDSRCVLSSNGErnhhhhhrylllgeAVDLSLDHKPIDPLERERIERAGGHID--EDLRVNGGLNMSRAIGDHMY
.|. .||||| |.||... ||||  |||. .| ..||              || |   ||| .. |..||| ||| .   . .|||| |..||||||  .
reklksGstavvvliekdqlyvaWlGDsqallvrkge..............avqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvkl

KtnetlplkdQMISAYPDVHTRLLQTQDQFLVLASDGIWNCLDSQQVVDFINAKLLEvRNSKKdlvlSHICEELCDACLAEDidndgtGCDNMSIIITLL
|         ...|. .|| .  |. ....|.||.||.|. .. ..||. ... | .  ....    |.. ..|..|   ..        ||..... .|
k.........pyvsgeadvaeveldgseeylilacDGlwDvvneeevvklveeflad.gaedl....sevakllveaakeag......ssDnitvvvvfl

KP
.|
dp
subfamily_PPM1L_pd Subfamily PPM1L 330-492 8.3e-27 87.1 In-house 104-249 (269) alignment 
Range on Protein: 330-492
Range on HMM: 104-249/269.0
HESGSTATVCLIKTNILYVANAGDSRCVLSSNGernhhhhhrylllGEAVDLSLDHKPIDPLERERIERAGGHID--EDLRVNGGLNMSRAIGDHmyktn
...|.|| . |.. . | ||| |||| ||  .              |.|. || |||| .. || ||..||| |      ||.| | .|||.||.     
diaGttalialvqesdlivanvGdsrGvlydkr.............GkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdy.....

etlPLKDQ-MISAYPDVHTR-LLQTQDQFLVLASDGIWNCLDSQQVVDFINAKLLEVRNSKKDLVLS
   ||||. .. | ||. |  | . . .||.|||||.|...  .. | ||  .| |     | ||| 
...plkdknlviadpdiltfdlddhkpeflilasdGlwdtfsneeavrfikerlkepdfGakslvle
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 330-476 1.5e-26 86.2 In-house 93-221 (255) alignment 
Range on Protein: 330-476
Range on HMM: 93-221/255.0
HESGSTATVCLIKTNILYVANAGDSRCVLSsngernhhhhhryLLLGEAVDLSLDHKPIDPLERERIERAGGHIDED---LRVNGGLNMSRAIGDHMYKt
   |.||.. ||  .  |.|| |||| ||.                | |. ||||||| .. |..||...|| . ..    |||| | .|||.||   . 
kfiGttaasvliiedkvyianvGdsrvvlc.............qkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsfle.

netlPlkdqMISAYPDVH-TRLLQTQDQFLVLASDGIWNCLDSQQVVDFIN
    |     . . ||.. .   ...|.||.|| ||||. .  .. |. . 
....P....fvvpdPdlsqsleiskkdkflilacdGiwdlisdeeaveiva
PPM_PTC7_SpoIIE 325-482 1.9e-25 83.0 In-house 81-212 (230) alignment 
Range on Protein: 325-482
Range on HMM: 81-212/230.0
HDSEGHE---SGSTATVCLIKTNI--LYVANAGDSRCVLSSNGERnhhhhhrylllgeavdlsldhkpidplERERIeRAGGHID---EDLRVNGGLNMS
.. . .|   ||.||.|.||  .   |||||||||...|......                           |||||  ||| ..   .. ||.| |..|
aadledepsssgaTavvalidpstgklyvanaGdsppllvrddgg...........................ereri.vagglpslGilpgrvfgvlavs

RAIGDHMYKTnetlplKDQMISAYPDVHTRLLQTQDQFLVLASDGIWNCLDSQQVVDFINAKLLEV
.|.||  ..       .|....| ||  . .|   |.||.|||||.|..|..|..||..   |.. 
lapGdlllly......tDGvveaepdtsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp
subfamily_PPM1D_pd Subfamily PPM1D 331-525 2.2e-24 79.1 In-house 107-308 (309) alignment 
Range on Protein: 331-525
Range on HMM: 107-308/309.0
ESGSTATVCLIKTNILYVANAGDSRCVLSSNGERNhhhhhrylLLGEAVDLSLDHKPIDPLERERIERAGGHIDED------------LRVNGG------
 .|.||.| .|. . ||||. |||. ||... ...           .|  |  |||| .| |.||||..||.. .             |. ||       
taGttasvviirreklyvahvGDsaivlgvkepke........kklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngptvidei

--LNMSRAIGDhMYKTNETlpLKDQMISAYPDVHTRLLQTQDQ-FLVLASDGIWNCLDSQQVVDFINAKLLEVRNS-KKDlvlSHICEELCDACLAEdID
  |...|..|| ..  |..   .  ..|  |||  | |..... |..|||||.||.| ....|.... .        ...   ... . | .  | .   
PFLavaRslGD.lWsynak..sgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqs...rsvakalvkealqr.wr

NDGTGCDNMSIIITLLK
.    .||.|.|. .|.
skklraDnvsvivvile
subfamily_PPM1G2_pd Subfamily PPM1G2 5-114 6.9e-22 70.7 In-house 2-112 (287) alignment 
Range on Protein: 5-114
Range on HMM: 2-112/287.0
LTKPITDKTVTNGtigvSDKECQYGTATMQGWRENMEDVITV----VT-DFDDKCSFLGVFDGHGGKEVSVYCSRHLPGFLKASVGYQDGDVSRGFCEAY
|..|...|  . .    ... .. |...|||.| ||||  ..    .. . |.......|||||||..|. |....|  ....   ...| ... . .|.
lsepvvakesasc....analtkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdaf

MNCDRKLLTEDALKE
...|..|| ...||.
letDeellkdeklkd
subfamily_PDP_pd Subfamily PDP 331-485 2.8e-21 69.1 In-house 151-318 (398) alignment 
Range on Protein: 331-485
Range on HMM: 151-318/398.0
ESGSTATVCLIKTNILYVANAGDSRCVLSSNGERNHHhhhrylllgEAVDLSLDHKPIDPLERERIERAGGHIDE-----DLRVNGGLNMSRAIGDHMYK
 ||..|.. ||. . |.|||.||.|.|| .. |. .          ||| || |.    . | |||...  . ..     . |. | |  .|| ||  ||
lsGacallaliegtelhvAntGDcravlgvqeeegsw.........eavkLskdqtadneeEveRikkeHPgeesktvirngRlLgeLqPlRAFGdvryK

TNET---LPLKD---Q-----------MISAYPDVHTRLLQTQDQFLVLASDGIWNCLDSQQVVDFINAKLLEVRNS
 .|     .|..   .            ..| |.| .. |...|.|||||.||.|..|....||. ..  | .  ..
wseelqkkvlekaylkvlepkdyktPPYltaePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkkek
subfamily_PPM1K_pd Subfamily PPM1K 324-476 3.4e-20 65.3 In-house 90-226 (263) alignment 
Range on Protein: 324-476
Range on HMM: 90-226/263.0
YHDSEGHESGSTATVCLIKT-NILYVANAGDSRCVLSSNGErnhhhhhrylllgeAVDLSLDHKPIDPLERERIERAGGHID----EDLRVNGGLNMSRA
. ..|  .||.||||.|..  . | .|. |||| .|  ||.              |  |. ||.|    |.||| .|||...    . ..||| | |.|.
vaeaellssGttatvsllrdGtelvlaslGdsrailcrnGk..............akkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrs

IGDhmyktnetLPLKDQMISAYPDVHTR-LLQTQDQFLVLASDGIWNCLDSQQVVDFIN
.||        | ||   . | |. ..  .  ..| |||| .||| . ..||.. |...
lGd........ldlkryGviatPetkslkvdhaadsflvlitdgisfvvnsqelcdlvr
subfamily_PP2D1_pd Subfamily PP2D1 317-491 1.7e-19 62.9 In-house 162-319 (492) alignment 
Range on Protein: 317-491
Range on HMM: 162-319/492.0
EEGDGDEYHDSEGHESGStATVCLIKTNILYVANAGDSRCVLSSNGERNHhhhhrylllgeavdLSLDHKPIDPLERERIERAGGHI---DEDLRVNGGL
|. . .. ..   .|| .   | |... .||.||||. . ||  .|.  .              |  .| | .. ||.|.|.||. .   ..  .||| |
ekeekkdseeGlekesng.sevhleelgvlyianaGnvqAvLcreGkaii..............LtreHtprnkkERtRvekagsvvvkseknglvnGil

NMSRAIGDHmyktnETLPLKDQMISAyPDVHTRLLQTQDQFLVLASDGIWNCLDSQQVVDFINAKLLEVR-NSKKDLVL
.  | .| .       . ||  .| . | ...  |. ..||||||| |.|. |. ..|.  ..  |   . . ... | 
dttRGLGny.....GdpkLkksvipe.PkttsvkldeaaqflvlAsnGlWevlseeevlsLvkqtlaiyksrvraenvp
subfamily_KAPP-like_pd Subfamily KAPP-like 332-477 2.8e-17 55.6 In-house 100-230 (266) alignment 
Range on Protein: 332-477
Range on HMM: 100-230/266.0
SGSTATVCLIK----TNILYVANAGDSRCVLSSNgErnhhhhhrylllgEAVDLSLDHKPIDPLERERIERAGGHIDE-DLRVNgGLNMSRAIGDHMYKT
 |.|||..|.        | ||| |||   ||   .             |.. || |||  || |. ||   |  . . . |.| || .|||.|||. | 
eGatatlalvwsdGqqrylqvanvGdssaflsrG.n.............eslelskdhkakdpeekqrikddGitlsdnqtrin.GlavsralGdhfike

NETlplkdqMISAYPDVHTRL-LQTQDQFLVLASDGIWNCLDSQQVVDFINA
 .        ... | |  |. |  .|.||..||||.|. .. .. .. ...
lni......GlisepyvsnrilltpfdkflivasdGlwdvisGkdaiekvks
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 332-477 3.4e-17 55.2 In-house 104-240 (276) alignment 
Range on Protein: 332-477
Range on HMM: 104-240/276.0
SGSTATVCLIKTNILYvANAGDSRCVLSSNGERNhhhhHRYLLLG-EAVDLSLDHKPIDPLERERIERAGGHIDE-DLRVNgGLNMSRAIGDHMYKTNET
 |.|||..|. ..     .  . | . ..|          .|  | |.. || |||  || |..||   |  . . . |.| || .|||.|||. |  . 
eGatatlalvwsdGee.qqqqqqrylqvanvGds....saflsrGneslelskdhkatdpeekqrikddGitlsdnqtrin.GlavsralGdhfikelni

lplkdqMISAYPDVHTRL-LQTQDQFLVLASDGIWNCLDSQQVVDFINA
       ... | |  |. |  .|.||..||||.|. .. .. .. ...
......GlisepyvsnrilltpfdkflivasdGlwdvisGkdaiekvks
subfamily_PPM1A_pd Subfamily PPM1A 23-130 2.9e-16 52.7 In-house 9-109 (282) alignment 
Range on Protein: 23-130
Range on HMM: 9-109/282.0
DKECQYGTATMQGWRENMEDVITVVTDFDDK--CSFLGVFDGHGGKEVSVYCSRHLPGFLKASVGYQDgdvsrgfceAYMNCDRKLLTEDALKEMKLINE
... .|| ..||||| .|||  |||...      ||  |||||.|.||. |...||.. .  .  ...         | .. . |  ...||..  |  .
gnglrygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelke.........aaleasekdevkealrqgfLald

SEINEGEEEL
..|.| ...|
eairelstdl
subfamily_TAB1_pd Subfamily TAB1 332-498 1.7e-14 46.3 In-house 129-295 (333) alignment 
Range on Protein: 332-498
Range on HMM: 129-295/333.0
SGSTATVCLIKTNILYVANAGDSRCVLSSNGErnhhhhhryllLGEAVDLSLDHKPIDPLERERIERAGGHIDED--LRVNGGLNMSRAIGDHM----YK
 |.|| | ||  | |||||.|||| .|  . |             . . || ||.   . | .|... |  |..    .. |. .  |.|||.     ||
gGttAvvalifnnkLyVaNvGdsrAllvkrke...........sekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkkgyk

TNETLP-LKDQMISAYPDVHTR-LLQTQDQFLVLASDGIWNCLDSQQVVDFINAK--LLEV-RNSKKDLVLSHICEEL
 .. |   |.. . | ||..    ..   .|||| |||. ..|.  .  .  | .  ||||  . .|.  |. . ...
dvdilssakgePviaePdiqgaypiddityflvlmSdGvyktLeevtgpetsnvenillevitelekqatlqdvAqav
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 329-422 2.1e-14 46.8 In-house 81-183 (292) alignment 
Range on Protein: 329-422
Range on HMM: 81-183/292.0
GHESGSTATVCLIKTNI--LYVANAGDSRCVLSS--NGERNhhhhhrylllgEAVDLSLDHKPIDPLERERIERAGGHID----------EDLRV-----
  ||..||.|| .  .   |..|| ||||..|     | ..           | . || |||| || ||.|| ||||...             ||     
aresattavvcarvrddralilanvGdsrallgrclggsdy...........eliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrq

-NGGLNMSRAIGDH
 .|.| .|||.|| 
qeGdlalsralGdf
PP2C_SIG_SM00331 324-505 5.5e-13 42.0 In-house 78-204 (217) alignment 
Range on Protein: 324-505
Range on HMM: 78-204/217.0
YHDSEGHESGSTATVCLI--KTNILYVANAGDSRCVLSSNGERNHHHHH-RYLLLGEAVDLSldhkpidplererieragghidedlrvngglnmsraig
|. .| .... |....|.  ... |..|||||||..|  .|.. ..... .  .||  ...|                                      
yeekeekgmfaTlllalydfssgklsyanaGdsrpyllrdgklveilkdvegaplGlepevs......................................

dhmyktnetlplkdqmisayPDVHTRLLQTqDQFLVLASDGIWNCLDSQQ-----VVDFINAKLlevrNSKKDLVLSHICEELCDACLAE
                    .|.... |.  . .|.|..||...   ...     . ... ...    .| .. . ..| |||. .  ..
....................vdirelelek.gdllllytDGltearsekgfaeerleeiledlv....dseaqelaqkiveellelakgs
subfamily_PPM1D_pd Subfamily PPM1D 31-106 1.1e-12 40.7 In-house 7-90 (309) alignment 
Range on Protein: 31-106
Range on HMM: 7-90/309.0
ATMQGWRENMEDVITVVTDFDDK-----CSFLGVFDGHGGKEVSVYCSRHLPGFLKASVGY---QDGDVSRGFCEAYMNCDRKL
.. || |. ||||...|.. ...      .|..||||||||| . . ..|| ...|   ..   .. || .   ||.... ...
eadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheam
PPM_PTC7 28-105 3.2e-12 39.4 In-house 3-88 (259) alignment 
Range on Protein: 28-105
Range on HMM: 3-88/259.0
YGTATMQGWRENMEDVITVVTDF-----DDKCSFLGVFDGHGGKEVSVYCSRHLPGFLKASVGYQDG-DVSRGFCEAYMNCD--RK
.|   .||.|..|||. ..  ..     .|. .|..||||||| |.. |.. ||...|| .   ... ...... ......|   .
ggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdee
0049733 PP2C-like 27-108 4.7e-12 39.0 In-house 4-81 (235) alignment 
Range on Protein: 27-108
Range on HMM: 4-81/235.0
QYGTATMQGW-RENMEDVITVvtdfddKCSFLGVFDGHGGKEVSVYCSRHLPGFLKAS-VGYQDGDVSRGFCEAYMNCDRKLLT
..|.|...|. |...|| . |      ......|.||||| ... ..|..|. .|..   ..   |. . . .|.. ... || 
svgaasdigrvrkvneDavlv......glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaanealle
PP2C Protein phosphatase 2C 28-110 7.8e-12 38.3 Pfam-A 3-92 (255) alignment 
Range on Protein: 28-110
Range on HMM: 3-92/255.0
YGTATMQGWRENMEDVITVVTDF-----DDKCSFLGVFDGHGGKEVSVYCSRHLPGFLKASVGYQDG-DVSRGFCEAYMN-CDRKLLTED
.|  ..||.|..||| ..   ..     ... .|..||||||| |.. |.. ||...|| .   ... .|.... .....  | .| ...
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelkssk
PP2C Protein phosphatase 2C 28-110 7.8e-12 38.3 In-house 3-92 (255) alignment 
Range on Protein: 28-110
Range on HMM: 3-92/255.0
YGTATMQGWRENMEDVITVVTDF-----DDKCSFLGVFDGHGGKEVSVYCSRHLPGFLKASVGYQDG-DVSRGFCEAYMN-CDRKLLTED
.|  ..||.|..||| ..   ..     ... .|..||||||| |.. |.. ||...|| .   ... .|.... .....  | .| ...
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelkssk
Subfamily Dicty-PPM1L-like 392-487 1.3e-11 36.9 In-house 182-271 (305) alignment 
Range on Protein: 392-487
Range on HMM: 182-271/305.0
ERERIERAGGHIDE--DLRVNGGLNMSRAIGDHMYKTNETlPLKDQMISAypdvhtrLLQTQDQFLVLASDGIWNCLDSQQVVDFINAKLLEVRNSKK
.| ||| ... . .  .|.||. |. || .||   |     | .|. .         . ...||||||| ||.|. |. |.||......| .   .||
iririeslqaalynygellvnrllkksrskGdknlkelvi.Pnndspllv.......vakanDqflvlatdGlwevlsyqdvveevkellrdkssqkk
PPM_PTC7_motif 456-506 3.6e-11 36.4 In-house 1-46 (51) alignment 
Range on Protein: 456-506
Range on HMM: 1-46/51.0
VLASDGIWNCLDSQQVVDFINAKLLEVRNskkdlVLSHICEELCDACLAED
.|||||.|..|..|..||...  | . ..      .  ..|.|.| .||. 
iLAsDGLWDvlsdqeavdlvrdqlskkgl.....spqeaAeklvdealarg
subfamily_PPM1E_pd Subfamily PPM1E 30-109 1.1e-09 30.8 In-house 8-94 (265) alignment 
Range on Protein: 30-109
Range on HMM: 8-94/265.0
TATMQGWRENMEDVITVVTDF--------DDKCSFLGVFDGHGGKEVSVYCSRHLPGFLkASVGYQDGDVSRGFCEAYMNCDRKLLTE
.|.... |  |||   .. |.        ... .|..||||||| | . | ..||. .| ..   .  |  . ..||. ..|...|. 
iaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhell.vrqeklkedpaealkeafkltDerflqk
subfamily_PPM1H_pd Subfamily PPM1H 408-485 1.3e-09 30.3 In-house 276-357 (404) alignment 
Range on Protein: 408-485
Range on HMM: 276-357/404.0
RVNGGLNMSRAIGDHMYKTNE-TLPLKdQMISAYPDVHTRLLQ----TQDQFLVLASDGIWNCLDSQQVVDFINAKLLEVRNS
|. . . ..| .|||  |. . .| .|  ..|. |.|... |.    ..|. |.||.||.|. |. ..|   ..  | .| ..
RllatigvtRGlGDheLkvvdtnlsik.PfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskvepe
subfamily_PHLPP_pd Subfamily PHLPP 388-478 2.6e-09 29.3 In-house 134-215 (246) alignment 
Range on Protein: 388-478
Range on HMM: 134-215/246.0
IDPLERERIERAGGHIDEDLRVNGGLNMSRAIGdHMYKTNETLPlkdqmisaYPDVHTRLLQTQDQFLVLASDGIWNCLDSQQVVDFINAK
|.  | .||  | . |.|| ..|| .. .| .| ...     ||         | |.  ||..|| .|.. .. .|. |. ...|. .  .
iekdelkrikeakaiitednkingviestrllG.ytflfPvvlP........kphvrevlLteqdellivGnkalWevlsideaveavrke
subfamily_PP2D1_pd Subfamily PP2D1 36-163 1.8e-08 26.5 In-house 13-138 (492) alignment 
Range on Protein: 36-163
Range on HMM: 13-138/492.0
WRENMEDVITVVTDFDDK--CSFLGVFDGHGGKEVSVYCSRHLPGFLKASVGYQDGDVSrgfceayMNCDRKLLTEDALKEMKLINESeINEGEEELNGE
|. .|||  |.. .| ..   .|.|..||. |.     ....|.  |   .   |  ||       . .. .|. .. | . .|   | ...   . . |
WKskmeDkrtlqdyfgndvnscFfgiyDGynGataAeiaakelhevlleelekvdervs.......lttavnlidnndltdyeleras.rsdsirailke

ESGD----EVERLTEEAHMPLDKVLQACIEDKKL
|| .    .|..  ..... ||..|.  ||.. .
esvkpefekvkkAfrksylrldrlLsygieeesr
PPM_PTC7_SpoIIE 28-105 2.2e-08 27.2 In-house 3-83 (230) alignment 
Range on Protein: 28-105
Range on HMM: 3-83/230.0
YGTATMQGWRENMEDVITVVTDF-----DDKCSFLGVFDGHGGKEvsVYCSRHLPGFLKASVgYQDGD-VSRGFCEAYMNCDRK
.|   .||.|..|||. ..  ..     ..   ..|..||||| .   .....| ..|..   ..... ..  . ... .....
ggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrela.faglekpeeilrrlnlalaad
subfamily_PPM1H_pd Subfamily PPM1H 330-397 2.9e-08 25.9 In-house 160-211 (404) alignment 
Range on Protein: 330-397
Range on HMM: 160-211/404.0
HESGSTATVCLIKTNILYVANAGDSRCVLSSNGERnhhhhhrylllgeaVDLSLDHKPIDplERERIE
 . | || | |. .. |||||||||| .|. ..|               ..|| |. |    ||.|. 
ikGGCtalvalvllgklYvanaGDsRailvrkdei..............iplsadftPet..eRqRlq
subfamily_ILKAP_pd Subfamily ILKAP 30-109 3e-08 26.2 In-house 9-103 (293) alignment 
Range on Protein: 30-109
Range on HMM: 9-103/293.0
TATMQGWRENMEDVITVVTDFDD----------KCSFLGVFDGHGGKEVSVYCSRHLPG-----FLKASVGYQDGDVSRGFCEAYMNCDRKLLTE
 |  .| ||.|.|. ... |.|.          . |. .|||||.|.  | .....|       . | .|  .. .. . . ... . |...|..
yaerkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefLkl
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 27-104 3.7e-08 26.0 In-house 7-86 (255) alignment 
Range on Protein: 27-104
Range on HMM: 7-86/255.0
QYGTATMQGWRENMEDVITVVTDFDDKC--SFLGVFDGHGGKEVSVYCSRHLPGFLKASVGYQDGDVSRGFCEAYMNCDR
. | . | | |  ||| ...   | ||    .. .||||||.. . ..| .|.  |.  .  .. .  . . .|| . . 
kvgfsdmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeist
subfamily_PPM1K_pd Subfamily PPM1K 29-108 4.4e-08 25.6 In-house 7-84 (263) alignment 
Range on Protein: 29-108
Range on HMM: 7-84/263.0
GTATMQGWRENMEDVITVvTDFDDKCSFLGVFDGHGGKEVSVYCSRHLPGFLKASVgYQDGDVSRGFCEAYMNCDRKLLT
|.....| |.. || |.. ...|..  ...|||||.|     ..  .|   ||     .. |.   . .|. ..|.||  
GkdsliGkraenedrikl.keldpellyvavfdGhaGsaaadfvhdklekilkrll.ekekdleivlknafeeldkklkr
subfamily_PPM1L_pd Subfamily PPM1L 30-88 6.5e-08 25.1 In-house 9-69 (269) alignment 
Range on Protein: 30-88
Range on HMM: 9-69/269.0
TATMQGWRENMEDVITVVTDFDDKC--SFLGVFDGHGGKEVSVYCSRHLPGFLKASVGYQD
. ...| |..||| ... .| ..|   ||..|||||||.  . ..   |.  .|. .   |
vysvlGrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklield
subfamily_Choan-PPM-1_pd Subfamily Choan-PPM-1 332-512 1.1e-06 20.1 In-house 134-309 (317) alignment 
Range on Protein: 332-512
Range on HMM: 134-309/317.0
SGSTATVCLIKTN-ILYVANAGDSRCVLSSNGERNHHHHHRYLLlgEAvdLSLDHKPIDPLERERIERA---GGHIDEDLRVNGGLNMSRAIGDHMYKTN
 |.||.| ..  .  . ||||||. ...  .   .| .   . .  ||  ||  |.     ||.|.. .    .|. ||  .    .  .|    . |. 
fGttavvavvvdethvvvanaGdaaalvllrdqaghedrdGlsv..ea..lsvrhtlrskaerarvaevlpgaahvtedgylaildealaayelqltksl

ETLPLKDQMISAYPDVHTRLLQTQDQFLVLA-SDGIWNCLDSQQVVDFINAKLLEVRNSkkdlvlSHICEELCDACLAEDIDNDGT
    ||   ..| |.|..| |.... | |.. |||| . |  ..|.| .         |        .|..  | .|.|.  .| |
GhkllkraGviadPevrsrvldvdevfavvvvsdGitdelkrldvldrvlraataleas......evlcddaqdylldetsiddat
PPM_PTC7_SpoIIE_motif 453-521 8.7e-06 19.3 In-house 13-77 (81) alignment 
Range on Protein: 453-521
Range on HMM: 13-77/81.0
QFLVLASDGIW-------NCLDSQQVVDFINAKllevrnSKKDlvLSHICEELCDACLAediDNDGTGCDNMSIII
  |.|..||..       .... .........       ..|.  | .....|.|..|.    ..|   |......
dvllLyTDGltEardsdgelfgkeellrladra......egks..lqeladklvdevle...ngsgereDDitllv