Gene C06A1.3 in Caenorhabditis elegans

Synonym: CELE_C06A1.3, CELE_C06A1.3

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily CelePPP-sf2
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP012_AA protein Get Run
CeleP012_AA_52-332 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 54-333 8.5e-206 674.5 In-house 1-280 (280) alignment 
Range on Protein: 54-333
Range on HMM: 1-280/280.0
NICNVMTGHEIISIIRMVEAIFMEESNLCEAEAPIKVIGDIHAQYQDMNRLFDLIGRVPEEKLMFLGDYVDRGPQGIEVLILLFCLKIRYRDRIYLLRGN
||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
nicnvmtgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgn

HETPSVNKIYGFYVECQYKYGIGLWWDFQSCFNRMPMSGLISKRVLCMHGGLSPELINLDTIRNIPRPCEPLDRGLLIDLLWSDPTNKGEGWFHSIRGIS
|||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
hetpsvnkiygfyvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgis

YMFGKGVVEQACKSLEIDLIIRAHQVVQDGYEMMTGRRLITVFSVPNYCAQFTNAAAVVCLNANLQISFQQMIPPPLPEG
||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||.||||.||||||||
ymfgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlippplpeg
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 53-331 4.1e-168 550.7 In-house 1-280 (281) alignment 
Range on Protein: 53-331
Range on HMM: 1-280/281.0
INICNV-MTGHEIISIIRMVEAIFMEESNLCEAEAPIKVIGDIHAQYQDMNRLFDLIGRVPEEKLMFLGDYVDRGPQGIEVLILLFCLKIRYRDRIYLLR
|||..| .|..||...||.|||||.||..|.|...||.|.||.|||..|..|||.|.||||||.|.|||||||||||..|||||||.|||||||||.|||
inihkvqytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllr

GNHETPSVNKIYGFYVECQYKYGIGLWWDFQSCFNRMPMSGLISKRVLCMHGGLSPELINLDTIRNIPRPCEPLDRGLLIDLLWSDPTNKGEGWFHSIRG
||||..||||||||||||..|||..||..||.||||.|.|.||.||||||||||||||..||..||.|.|...|||||.|||||.||.||.|.|..|.||
gnheiasvnkiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrG

ISYMFGKGVVEQACKSLEIDLIIRAHQVVQDGYEMMTGRRLITVFSVPNYCAQFTNAAAVVCLNANLQISFQQMIPPPLP
.|..|||.||...||.||..||||||||||||||...||.||||||||||||...|||||......|.||.....|...|
ssftfGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpasep
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 52-327 7.8e-111 362.8 In-house 17-293 (298) alignment 
Range on Protein: 52-327
Range on HMM: 17-293/298.0
NINICNVMTGHEIISIIRMVEAIFMEESNLCEAEAPIKVIGDIHAQYQDMNRLFDLIGRVPEEKLMFLGDYVDRGPQGIEVLILLFCLKIRYRDRIYLLR
. ....|.. ... ..|.... || . . | | .||||| |||| ||.|. ||||  |  |..  .||||||||| | .||..||.. |..| ....|||
ekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnffllr

GNHETPSVNKIYGFYVECQYKY-GIGLWWDFQSCFNRMPMSGLISKRVLCMHGGLSPELINLDTIRNIPRPCEPLDRGLLIDLLWSDPTNKGEGWFHSIR
||||....|..|||| ||. .|  . |. .||  || .|. .||..|.||||||||..| .||..|.. || .. .  | |||||.||.|. .|| .. |
GnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenavkgwaensr

GISYMFGKGVVEQACKSLEIDLIIRAHQVVQDGYEMMTGRRLITVFSVPNYCAQFTNAAAVVCLNANLQISFQQMIP
|.|..||. ||.. ...|.|||..|||||||||||......|.|.|| |.|| ||.|.|||. ....|..||. . |
GvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkp
PP2Ac_SM00156 60-327 1.3e-110 361.7 In-house 2-269 (271) alignment 
Range on Protein: 60-327
Range on HMM: 2-269/271.0
TGHEIISIIRMVEAIFMEESNLCEAEAPIKVIGDIHAQYQDMNRLFDLIGRVPEEKLMFLGDYVDRGPQGIEVLILLFCLKIRYRDRIYLLRGNHETPSV
. .|...... |..|...|.||.|..||. |.|||| |..|. ||..| |..|||| .|||||||||||.|||..|||.|||.| ....|||||||..||
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

NKIYGFYVECQYKYGIGLWWDFQSCFNRMPMSGLISKRVLCMHGGLSPELINLDTIRNIPRPCEPLDRGLLIDLLWSDPTNKGEGWFHSIRGISYMFGKG
||||||. |...|||  ..  |...|. .|.. |.....||||||||||| .||.||.. |. |. ..|||||||||||..| .|. .|.||.|..||. 
nkiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFged

VVEQACKSLEIDLIIRAHQVVQDGYEMMTGRRLITVFSVPNYCAQFTNAAAVVCLNANLQISFQQMIP
.|.. .|.....||||||.||..|||... ..|.|.|| ||||..|.|.|||. .. ||..|..|. .
avkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlke
subfamily_PPP1C_pd Subfamily PPP1C 58-326 8.6e-108 352.8 In-house 9-277 (282) alignment 
Range on Protein: 58-326
Range on HMM: 9-277/282.0
VMTGHEIISIIRMVEAIFMEESNLCEAEAPIKVIGDIHAQYQDMNRLFDLIGRVPEEKLMFLGDYVDRGPQGIEVLILLFCLKIRYRDRIYLLRGNHETP
 .. .|| ..... ..|..... | | |||.|..|||| ||.|. |||.  |  ||.. .||||||||| |..|...||...||.| ....|||||||. 
klkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesa

SVNKIYGFYVECQYKYGIGLWWDFQSCFNRMPMSGLISKRVLCMHGGLSPELINLDTIRNIPRPCEPLDRGLLIDLLWSDPTNKGEGWFHSIRGISYMFG
|.|.||||| ||. .|.| ||  |. .|| .|.. |.....||.|||||||| .|. ||.| ||.|  ..|||.||||||| .. .|| .. ||.|. ||
sinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsftfg

KGVVEQACKSLEIDLIIRAHQVVQDGYEMMTGRRLITVFSVPNYCAQFTNAAAVVCLNANLQISFQQMI
| |||. ... ..|||.||||||.||||... |.|.|||| ||||..| ||.||......| .||| . 
kdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilk
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 39-327 9e-106 346.4 In-house 5-293 (299) alignment 
Range on Protein: 39-327
Range on HMM: 5-293/299.0
DCIKRMNSLYKDtNINICNVMTGHEIISIIRMVEAIFMEESNLCEAEAPIKVIGDIHAQYQDMNRLFDLIGRVPEEKLMFLGDYVDRGPQGIEVLILLFC
. . .. .. .  . .. . .  .|.... ..   .|.... | | ||||.| |||| || |. |.||  |  |. . .||||||||| | .|...||.|
ellskllnvgms.ekrltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllc

LKIRYRDRIYLLRGNHETPSVNKIYGFYVECQYKYG-IGLWWDFQSCFNRMPMSGLISKRVLCMHGGLSPELINLDTIRNIPRPCEPLDRGLLIDLLWSD
 ||.| .|...|||||| |..|..|||| ||. .|    ||  || .|. ||..|||. |.|||||||||.| .||..|...|| .| .  | |||||.|
fkikyperffmlrgnhecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwad

PTNKGEGWFHSIRGISYMFGKGVVEQACKSLEIDLIIRAHQVVQDGYEMMTGRRLITVFSVPNYCAQFTNAAAVVCLNANLQISFQQMIP
| .   .|   .||.||.||. ||.. .. |.|||. |||||||||||... ..|.|.|| | || || |.||.. .. ||  .|. . |
pdqsvkdwlanvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkp
0045823 Metallo-dependent phosphatases 54-332 1.6e-101 333.3 In-house 38-328 (473) alignment 
Range on Protein: 54-332
Range on HMM: 38-328/473.0
NICNVMTGHEIISIIRMVEAIFMEESNLCEAEAPIKVIGDIHAQYQDMNRLFDLIGRVPEEKLMFLGDYVDRGPQGIEVLILLFCLKIRYRDRIYLLRGN
  ..... ..........  |...|.|| | ...| |||||| |. |. ||...||. ||..| ||||.|||||...||| ||..|||.| ....|||||
kkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkikypgnvfllrGN

HETPSVNKIYGFYVECQYKYGIGLWWDFQSCFNRMPMSGLISKRVLCMHGGLSPELINLDTIRNIPRPCEPLDRGLLIDLLWSDPtNKGEG--------W
||.  .| .|||. |. .|||. |. .|. .....| . .| ...|..||||||.| .|| ||.|.||.|..| ||| |||||||    .|        .
HElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdP.weddgdgllrlrff

FHSIRGISYMFGKGVVEQACKSLEIDLIIRAHQVVQDGYEMMTGRR------LITVFSVPNYCAQFTNAAAVVCLNANLqISFQQMIPPPLPE
 .| ||..|.||. .||. .|   .|||.|.|..|..|||.. ...      .||||| |||| .. | |||.... .| |||.|. | | | 
gnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsphpl
PPP_3 61-325 2.4e-98 321.5 In-house 4-269 (271) alignment 
Range on Protein: 61-325
Range on HMM: 4-269/271.0
GHEIISIIRMVEAIFMEESNLCEAEAPIKVIGDIHAQYQDMNRLFDLIGRVPEEKLMFLGDYVDRGPQGIEVLILLFCLKIRYRDRIYLLRGNHETPSVN
 .|. ....... |...||||.| .||..|.|||| |..|...||.  |..||.| .||||||||| ...|||.||..|||.| ....|||||||. ..|
enelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrqin

KIYGFYVECQ-YKYGIGLWWDFQSCFNRMPMSGLISKRVLCMHGGLSPELINLDTIRNIPRPCEPLDRGLLIDLLWSDPTNKGEGWFHSIRGISYMFGKG
|.|||. |..  |.|  ..  .|..|. .|.. ||...||..||||||.. .||.|... |..|  ..|.|.|||.|....| ||. .| ||....||. 
kvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFgpd

VVEQACKSLEIDLIIRAHQVVQDGYEMMTGRRLITVFSVPNYCAQFTNAAAVVCLNANLQISFQQM
|.|. ... ...||||||.....|||... ....||||.|||| ...||.|.. |...|. .|.|.
vteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkql
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 59-327 4.4e-97 317.6 In-house 6-274 (280) alignment 
Range on Protein: 59-327
Range on HMM: 6-274/280.0
MTGHEIISIIRMVEAIFMEESNLCEAEAPIKVIGDIHAQYQDMNRLFDLIGRVPEEKLMFLGDYVDRGPQGIEVLILLFCLKIRYRDRIYLLRGNHETPS
.   .| ..|. .. |.. .. . | .||..| ||.| || |. |||. ..  |... .||||||||| | .||..||.. |.|| .....||||||. |
ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevis

VNKIYGFYVECQYKYGIGLWWDFQSCFNRMPMSGLISKRVLCMHGGLSPELINLDTIRNIPRPCEPLDRGLLIDLLWSDPTNKGEGWFHSIRGISYMFGK
.|. |||. |.. .|   |. .||  .. .|.  |.| |.||||||||..|. || .... || .. |  |  ||||.|| ||  || .. ||.|..||.
inrkygfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifga

GVVEQACKSLEIDLIIRAHQVVQDGYEMMTGRRLITVFSVPNYCAQFTNAAAVVCLNANLQISFQQMIP
 || . .. |.||||.| |||||||||......|.|||| |.|. .|.|.|||. ....|..||. . |
nvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkp
0049330 Metallo-dependent phosphatases 53-330 2.5e-95 312.1 In-house 24-301 (309) alignment 
Range on Protein: 53-330
Range on HMM: 24-301/309.0
INICNVMTGHEIISIIRMVEAIFMEESNLCEAEAPIKVIGDIHAQYQDMNRLFDLIGRVPEEKLMFLGDYVDRGPQGIEVLILLFCLKIRYRDRIYLLRG
.  . ... .|.. .. ..  |...|.|| | ...| |||||| |. |. ||...|| .|| .| ||||.|||||...||| ||..||..|.|...||||
llklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkllypdnvfllrG

NHETPSVNKIYGFYVECQYKYGIGLWWDFQSCFNRMPMSGLISKRVLCMHGGLSPELINLDTIRNIPRPCEPLDRGLLIDLLWSDPTNKGEGWFHSIRGI
|||.  .| .|||. |...|||. || .|. .....|.  .| ...||.||||||.| .|| ||.. ||.|. . ||| |||||||..  ||. ...||.
NHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpiregfapnprgl

SYMFGKGVVEQACKSLEIDLIIRAHQVVQDGYEMMTGRRLITVFSVPNYCAQFTNAAAVVCLNANLQISFQQMIPPPL
.. ||  .||. .| . .|||||.|..|..||... ...|||||| |||| .. |..||.... .| |||... | ||
gvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpl
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 56-327 3.8e-93 304.5 In-house 7-281 (287) alignment 
Range on Protein: 56-327
Range on HMM: 7-281/287.0
CNVMTGHEIISIIRMVEAIFMEESNLCEAEAPIKVIGDIHAQYQDMNRLFDLIGRVPEEKLMFLGDYVDRGPQGIEVLILLFCLKIRYRDRIYLLRGNHE
 . .. ..|..... .| |.   . | | ||||...|||| |..|. |.|. .|. |. . .|||||||||.. .|| .|||.|||.|  ...|||||||
ldafsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhe

TPSVNKIYGFYVECQYKYGIGLWWDFQSCFNRMPMSGLISKRVLCMHGGLSPELINLDTIRNIPRPCEPLDR--GLLIDLLWSDPTNKGEGW-FHSIRGI
   .||.|||. | . |..  |.  |.  |. .|.   .|||.||||||.||.|  || .. ...|  ||.   || .||||.||... ..  .  ||.|
vkkinklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkirai

SYMFGKGVVEQACKSLEIDLIIRAHQVVQDGYEMMTGRRLITVFSVPNYCAQFTNAAAVVCLNANLQISFQQMIP
| .||| .|.. .| |.||||.|||.|...||...  .||.|||| | |... || .||| ..  |..|| .. |
svvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkp
0053225 Metallo-dependent phosphatases 53-327 9.2e-89 290.7 In-house 16-290 (293) alignment 
Range on Protein: 53-327
Range on HMM: 16-290/293.0
INICNVMTGHEIISIIRMVEAIFMEESNLCEAEAPIKVIGDIHAQYQDMNRLFDLIGRVPEEKLMFLGDYVDRGPQGIEVLILLFCLKIRYRDRIYLLRG
. .. ... .|.. .. ..  |...|.|| | ...| |||||| .. |. .|...|| .||..| ||||.|||||...||| ||..||..|.|...||||
llllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllypdnvvllrG

NHETPSVNKIYGFYVECQYKY-GIGLWWDFQSCFNRMPMSGLISKRVLCMHGGLSPELINLDTIRNIPRPCEPLDRGLLIDLLWSDPTnKGEGWFHSIRG
|||.  .| .|||. |. .|| .  || ... ... .|.. || ...|..||||||.|..|| ||.| ||... ..||| |||||||.   .|| .|.||
NHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpd.lwsgwlpsyrg

ISYMFGKGVVEQACKSLEIDLIIRAHQVVQDGYEMMTGRRLITVFSVPNYCAQFTNAAAVVCLNANLQISFQQMIP
... ||  .|.. .|   .|||||.||||.|||... ...|.|||| |||. ...|..||..|. .| ..|... |
lgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfap
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 56-325 4.5e-87 285.1 In-house 5-280 (284) alignment 
Range on Protein: 56-325
Range on HMM: 5-280/284.0
CNVMTGHEIISIIRMVEAIFMEESNLCEAEAPIKVIGDIHAQYQDMNRLFDLIGRV------PEEKLMFLGDYVDRGPQGIEVLILLFCLKIRYRDRIYL
 .... .|.| .      .| .|.   | |||.|..|||| |..|.  |.|| |         |.| .||||||||||  |||. |||..|... |...|
qkllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfl

LRGNHETPSVNKIYGFYVECQYKYGIGLWWDFQSCFNRMPMSGLISKRVLCMHGGLSPELINLDTIRNIPRPCEPLDRGLLIDLLWSDPTNKGEGWFHSI
||||||.  ||. |||| ||. .|   |.  || .|| ||.. ..||...|||||.| .|..|. . .. ||..  | |.. || |.|| .. ||. .| 
lrgnhesrpvnmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesp

RGISYMFGKGVVEQACKSLEIDLIIRAHQVVQDGYEMMTGRRLITVFSVPNYCAQFTNAAAVVCLNANLQISFQQM
||   .||.  |.. .|  ..||..||||||.||||... |.|.|.|| | || |. |.|||. .. .| .||. .
rgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvl
subfamily_PPP4C_pd Subfamily PPP4C 53-323 1.8e-86 283.0 In-house 10-280 (288) alignment 
Range on Protein: 53-323
Range on HMM: 10-280/288.0
INICNVMTGHEIISIIRMVEAIFMEESNLCEAEAPIKVIGDIHAQYQDMNRLFDLIGRVPEEKLMFLGDYVDRGPQGIEVLILLFCLKIRYRDRIYLLRG
.. |.... .|. .. . .. |..||||. . ..|. | |||| |..|. .||.. | |||.. .||||.||||   .| ..|| .||.|| |||.|.||
lrrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirg

NHETPSVNKIYGFYVECQYKYGIGLWWD-FQSCFNRMPMSGLISKRVLCMHGGLSPELINLDTIRNIPRPCEPLDRGLLIDLLWSDPTNKgEGWFHSIRG
|||. .. ..|||| ||  |||    |      |. .... .| ....|.||||||.. .|| || | |  |  . | |.||||||| .. |||  | ||
nhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpeda.egwavsprg

ISYMFGKGVVEQACKSLEIDLIIRAHQVVQDGYEMMTGRRLITVFSVPNYCAQFTNAAAVVCLNANLQISFQ
  |.||. |||| ... .|.||.||||.|..|| ..  ....||.| |||| .  | ||.. |...|.  |.
agylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfk
PPP_1 62-312 5.3e-85 277.9 In-house 4-262 (264) alignment 
Range on Protein: 62-312
Range on HMM: 4-262/264.0
HEIISIIRMVEAIFMEESNLCEAEAPIKVIGDIHAQYQDMNRLFDLIGRVPEEKLMFLGDYVDRGPQGIEVLILLFCLKIRYRDRIYLLRGNHETPSVNK
.|......... ....|.|| | ...|.|.|||| |..|...||   | .||.. .||||||||| . .|.|.||..||..|.....|||||||. .|.|
eelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvtk

IYGFYVECQ-YKYGIGLWWDFQSCFNRMPMSGLISKRVLCMHGGLSPELINLDTIRNIPRPCEPLDRGLLIDLL-------WSDPTNKGEGWFHSIRGIS
.|||. |.. .||.  ..  .. .|. .|.. || ...|..||||||||  || ||.. |  |  ..| | |||       .||.... |.. .||||..
vygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRGag

YMFGKGVVEQACKSLEIDLIIRAHQVVQDGYEMMTGRRLITVFSVPNYCAQFTNAAAVV
|.||| |.|. ... ...||||||.|...|||... |...|.|| .||. ...|..|.|
ylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayv
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 65-325 9.6e-84 274.1 In-house 9-271 (284) alignment 
Range on Protein: 65-325
Range on HMM: 9-271/284.0
ISIIRMVEAIFMEESNLCEAEAPIKVIGDIHAQYQDMNRLFDLIGRVPEEKLMFLGDYVDRGPQGIEVLILLFCLKIRYRDRIYLLRGNHETPSVNKIYG
 ...  . .|| ..  | |...||.. |||| |. |. ||||  |     . .||||||||| . .| ..|||. |. . .....||||||   .|||||
etllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinkiyg

FYVECQYKYGI-GLWWDFQSCFNRMPMSGLISKRVLCMHGGLSPELINLDTIRNIPRPCE-PLDRGLLIDLLWSDPTNKGEGWFHSIRGISYMFGKGVVE
|| ||| .|    ..  |.  |  ||.. |. .|.||||||.|  | |.  .| | || . |    | ||.|||||||  .||    ||.||.||   . 
fyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsdalr

QACKSLEIDLIIRAHQVVQDGYEMMTGRRLITVFSVPNYCAQFTNAAAVVCLNANLQISFQQM
.    |.|||..|||||||||||... |||.|.|| | || || |||||. .| ||  ||  .
klldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvl
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 54-327 2.7e-83 272.7 In-house 18-294 (297) alignment 
Range on Protein: 54-327
Range on HMM: 18-294/297.0
NICNVMTGHEIISIIRMVEAIFMEESNLCEAEAPIKVIGDIHAQYQDMNRLFDLIGRVPEEKLMFLGDYVDRGPQGIEVLILLFCLKIRYRDRIYLLRGN
 ...|.| . .. .. .   .|  . .. | .||||| |||| |. |. |||   |  |  . .|||||||||   || ..||.. |...   ..|||||
llskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgn

HETPSVNKIYGFYVECQYKYG-IGLWWDFQSCFNRMPMSGLISKRVLCMHGGLSP---ELINLDTIRNIPRPCEPLDrGLLIDLLWSDPTNKGEGWFHSI
||   |||.|||| ||| .|  . ..  ||  || .|..|||....|||||||||   . . |||.|.| |. |  . .|. ||||.||     |...  
hecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierstegke.rlvadllwadpisglsgfmenq

RGISYMFGKGVVEQACKSLEIDLIIRAHQVVQDGYEMMTGRRLITVFSVPNYCAQFTNAAAVVCLNANLQISFQQMIP
||    ||.  | . |  ...||. |||||||||||...||.|.|.|| | || || |.||..  . .|| ||. . |
rgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilrp
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 114-327 1e-82 270.9 In-house 101-314 (317) alignment 
Range on Protein: 114-327
Range on HMM: 101-314/317.0
EKLMFLGDYVDRGPQGIEVLILLFCLKIRYRDRIYLLRGNHETPSVNKIYGFYVECQYKYGIGLWWDFQSCFNRMPMSGLISKRVLCMHGGLSPELINLD
.| .||||||||||  |||.||||.||..| |...|||||||. .||. |||| |....|   |.  ||  || .|.. ...|..||||||.| ||..|.
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldlk

TIRNIPRPCEPLDRGLLIDLLWSDPTNKGEGWFHSIRGISYMFGKGVVEQACKSLEIDLIIRAHQVVQDGYEMMTGRRLITVFSVPNYCAQFTNAAAVVC
 . .. ||..  | |.| || |.|| .. .|. .| || . .||.  |.. .| |..||..||||||.||||.. .|.|.|.|| |.|| |. |.|||. 
qldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavls

LNANLQISFQQMIP
.. .|.||.. . |
vdkklkisinvlrp
subfamily_PPP2C_pd Subfamily PPP2C 52-328 1.5e-82 270.0 In-house 10-286 (290) alignment 
Range on Protein: 52-328
Range on HMM: 10-286/290.0
NINICNVMTGHEIISIIRMVEAIFMEESNLCEAEAPIKVIGDIHAQYQDMNRLFDLIGRVPEEKLMFLGDYVDRGPQGIEVLILLFCLKIRYRDRIYLLR
... |. .. .|. ... ... |...|||. | ..|. |.||.| |..|.  || . |..|. . .|||||||||   .| . || .||.||..|| .||
klkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilr

GNHETPSVNKIYGFYVECQYKYGIG-LWWDFQSCFNRMPMSGLISKRVLCMHGGLSPELINLDTIRNIPRPCEPLDRGLLIDLLWSDPTNKgEGWFHSIR
||||.  . ..|||| ||  |||   .|  |   |. .|...|. ....|.||||||..  || ||.. |  |  . | | ||||||| .. .||  | |
gnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddr.ggwgispr

GISYMFGKGVVEQACKSLEIDLIIRAHQVVQDGYEMMTGRRLITVFSVPNYCAQFTNAAAVVCLNANLQISFQQMIPP
|  | ||| . |.  |. .. ||.||||.| .||...  |...|.|| |||| .  | ||.. |. .|. || |. | 
gagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpa
subfamily_PPZ_pd Subfamily PPZ 53-325 5.1e-82 268.7 In-house 21-291 (300) alignment 
Range on Protein: 53-325
Range on HMM: 21-291/300.0
INICnvMTGHEIISIIRMVEAIFMEESNLCEAEAPIKVIGDIHAQYQDMNRLFDLIGRVPEEKLMFLGDYVDRGPQGIEVLILLFCLKIRYRDRIYLLRG
 |.|  .   ||. |      .|. . .| |   ..|..||.| || |. |||   |  |  . .||||||||| | .| ..||.| ||.| . ..||||
knvc..lknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrg

NHETPSVNKIYGFYVECQYKYGIGLWWDFQSCFNRMPMSGLISKRVLCMHGGLSPELINLDTIRNIPRPCEPLDRGLLIDLLWSDPTNKGEGWFHSIRGI
|||   | ..|||| ||. .  | .|  |   || .|.. ... ...|.|||||| | ..| || . || .  | ||. ||||||||.  . |    ||.
nhecanvtrvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergv

SYMFGKGVVEQACKSLEIDLIIRAHQVVQDGYEMMTGRRLITVFSVPNYCAQFTNAAAVVCLNANLQISFQQM
|| . |  ...  . . .||. ||| ||.||||..  | |.|||| |||| .| |  ||....  |  ||. .
sycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfell
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 55-326 6.7e-80 261.2 In-house 12-287 (290) alignment 
Range on Protein: 55-326
Range on HMM: 12-287/290.0
ICNVMTGHEIISIIRMVEAIFMEESNLCEAEAPIKVIGDIHAQYQDMNRLFDLIGRVPEEKLMFLGDYVDRGPQGIEVLILLFCLKIRYRDRIYLLRGNH
. . .. ..|..|.. .| |.     | | |||| ..|||| | ... | || .|. |. | .|||||||||.. .|| .||||.||||  ...||||||
vldafsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnh

ETPSVNKIYGFYVECQYKYGIGLWWDFQSCFNRMPMSGLISKRVLCMHGGLSPELINLDTIRNIPRPCEPL--DRGLLIDLLWSDPTN-KGEG-WFHSIR
|.  ||..|||. |   | |  ||  .|  |. ...   .....||||||.|...   .... . .|  ||  |.|| .||||.|||. | .   .   |
evrkvnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqr

GISYMFGKGVVEQACKSLEIDLIIRAHQVVQDGYEMMTGRRLITVFSVPNYCAQFTNAAAVVCLNANLQISFQQMI
.|| .||| .... .| | ..||.|||.| ..|....  ..|.|||| | |. . ||  |.. .   |..|.  . 
aisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlk
subfamily_PPP6C_pd Subfamily PPP6C 53-319 9.5e-80 260.8 In-house 9-275 (290) alignment 
Range on Protein: 53-319
Range on HMM: 9-275/290.0
INICNVMTGHEIISIIRMVEAIFMEESNLCEAEAPIKVIGDIHAQYQDMNRLFDLIGRVPEEKLMFLGDYVDRGPQGIEVLILLFCLKIRYRDRIYLLRG
.. |. ..  ..  .  .|  ...||||.   ..|. | |||| |. |.. ||   |.||... .||||.||||   .| . .|..||..| ||| ||||
akkckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrg

NHETPSVNKIYGFYVECQYKYGIGLWWDF-QSCFNRMPMSGLISKRVLCMHGGLSPELINLDTIRNIPRPCEPLDRGLLIDLLWSDPtNKGEGWFHSIRG
|||.  . ..|||| ||. ||| .  | .  . |. .... .| ..|||.||||||..  || || | |  |   .| . ||.|||| .. | |  | ||
nhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdp.edvetwavsprg

ISYMFGKGVVEQACKSLEIDLIIRAHQVVQDGYEMMTGRRLITVFSVPNYCAQFTNAAAVVCLNANLQ
  |.||. |... ..  ...||.||||.|..|.. |   .|.||.| |||| .  | |... |. . .
agylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaee
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 60-327 3.8e-77 252.5 In-house 21-291 (307) alignment 
Range on Protein: 60-327
Range on HMM: 21-291/307.0
TGHEIISIIRMVEAIFMEESNLCEAEAPIKVIGDIHAQYQDMNRLFDLIGRVPEEKLMFLGDYVDRGPQGIEVLILLFCLKIRYRDRIYLLRGNHETPSV
|  |.  .|   ..||  |  | . . |  |.||.| |..|.  .| |.|| ||   .| |||||||   .|...|||. || | . | |||||||   |
tkeefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarv

NKIYGFYVECQ---YKYGIGLWWDFQSCFNRMPMSGLISKRVLCMHGGLSPELINLDTIRNIPRPCEPLDRGLLIDLLWSDPTNKGEGWFHSIRGISYMF
|| |||| ||     | |  .|  || ||| .|.| ||. ..||||||||| |  || .|| |.|     ||.. |.||.||      |  | ||  . |
nkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftf

GKGVVEQACKSLEIDLIIRAHQVVQDGYEMMTGRRLITVFSVPNYCAQFTNAAAVVCLNANLQISFQQMIP
|  |... || | ..|||||||.. ||| ...||.|||.|| | ||  . || .|. ..  | |    ..|
gtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvp
subfamily_PPP5C_pd Subfamily PPP5C 61-325 9.9e-73 237.9 In-house 36-306 (322) alignment 
Range on Protein: 61-325
Range on HMM: 36-306/322.0
GHEIISIIRMVEAIFMEESNLCEAEAP----IKVIGDIHAQYQDMNRLFDLIGRVPEEK-LMFLGDYVDRGPQGIEVLILLFCLKIRYRDRIYLLRGNHE
   ...|. ...... ... |.| . .    . | ||||.|. |.  .|.| |.. ||.  .| ||.||||   .||...|...|. | ....| |||||
kkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhe

TPSVNKIYGFYVECQYKYGIGLWWDFQSCFNRMPMSGLISKRVLCMHGGL-SPELINLDTIRNIPRPCEPLDRGLLIDLLWSDPTNKgEGWFHSIRGISY
. ..||.|||  |...||   .   |.  || .|.. .| ..|| .|||| | . ..|| .|.| | ..| . |||..|||||| .. .|  .| ||.. 
sdnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqea.nGrspskrGvgv

MFGKGVVEQACKSLEIDLIIRAHQVVQDGYEMMTGRRLITVFSVPNYCAQFTNAAAVVCL-NANLQISFQQM
 ||  | .. .|. ...||||.|.| ..|||..   .|||||| |||| | .| .|.. | ...|.. |...
qfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfktf
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 81-327 8.3e-72 235.0 In-house 2-255 (263) alignment 
Range on Protein: 81-327
Range on HMM: 2-255/263.0
LCEAEAPIKVIGDIHAQYQDMNRLFDLIGRVPEEKLMFLGDYVDRGPQGIEVLILLFCLKIRYRDRIYLLRGNHETPSVNKIYGFYVECQYKYGI-----
| | .|||.. || | ||.|. |.|.  |   . . .||||||||| . .||..||| ||.    ...|||||||  ..|| |||. | . ..       
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

GLWWDFQSCFNRMPMSGLISKRVLCMHGGLSPELINLDTIRNIPRPCEPLD-RGLLIDLLWSDPTNKGEGWF-HSIRGISYMFGKGVVEQACKSLEIDLI
 ..  |.  |. ||.  ..|||.||||||.|| | .|| || || | |    . |  ||||.|| .  .|.    || || .|||  |.. || |.||||
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidli

IRAHQVVQDGYEMMTGRRLITVFSVPNYCAQFTNAAAVVCLNANLQISFQQMIP
.||||||. || ... ||||||||   |  .. | |||| .|  |..|| |. |
vrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkp
subfamily_PPP3C_pd Subfamily PPP3C 59-318 1.5e-71 234.5 In-house 41-314 (452) alignment 
Range on Protein: 59-318
Range on HMM: 41-314/452.0
MTGHEIISIIRMVEAIFMEESNLCEAEAPIKVIGDIHAQYQDMNRLFDLIGRVPEEKLMFLGDYVDRGPQGIEVLILLFCLKIRYRDRIYLLRGNHETPS
.. .... ||... ... .|..| | |||| |||||| |. |. .||.. |   . | .|||||||||   ||... |..||| | ....|||||||.  
leeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrh

VNKIYGFYVECQYKYGIGLWWDFQSCFNRMPMSGLISKRVLCMHGGLSPELINLDTIRNIPRPCEPLDRGLLIDLLWSDPTNKG-----EGWF--HSIRG
. . . |  ||..||.  ..  . ..|. .|.. |. .. ||.|||||||. .|| |... |  ||  .|.| |||||||...      |  |   |.||
lteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpnsvrG

ISYMFGKGVVEQACKSLEIDLIIRAHQVVQDGYEMMTG------RRLITVFSVPNYCAQFTNAAAVVCLNAN-L
 ||...   | .  .. ..  |||||.. ..||.|           |||.|| |||.  ..| |||. .. | .
csyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennvm
subfamily_PPG1_pd Subfamily PPG1 54-324 7.7e-71 231.8 In-house 9-292 (300) alignment 
Range on Protein: 54-324
Range on HMM: 9-292/300.0
NICNVMTGHEIISIIRMVEAIFMEESNLCEAEAPIKVIGDIHAQYQDMNRLFDLIGRVPEEKLMFLGDYVDRGPQGIEVLILLFCLKIRYRDRIYLLRGN
. ....    . ...  .  ....|||. | ..|. |.||.| |. |.  .|.. |.||. . .|||||||||   .| ..|| .||.||  || |||||
qkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgn

HETPSVNKIYGFYVECQYKY-G-IGLWWDFQSCFNRMPMSGLISKRVLCMHGGLSPELINLDTIRNIPRPCEPLDRGLLIDLLWSDPT-----------N
||.  . ..|||| ||  || |   .|  .   |. . .. .| . . |.||||||.   .| |. . |  |  . | | |||||||            .
hesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdr

KGEGWFHSIRGISYMFGKGVVEQACKSLEIDLIIRAHQVVQDGYEMMTGRRLITVFSVPNYCAQFTNAAAVVCLNANLQISFQQ
.|. .  | ||  | .|| |||.  .  ... ||||||....||...   .| ||.| |||| .  | |... |. ...  |. 
egqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnv
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 115-325 5.1e-69 225.9 In-house 121-331 (339) alignment 
Range on Protein: 115-325
Range on HMM: 121-331/339.0
KLMFLGDYVDRGPQGIEVLILLFCLKIRYRDRIYLLRGNHETPSVNKIYGFYVECQYKYGIGLWWDFQSCFNRMPMSGLISKRVLCMHGGLSPELINLDT
. .||||||||||  .||.||| .||. | |||||||||||. |||  |||| | .|.|   |.  ||  || .|.  .| . ..|||||.|  |  .. 
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfnq

IRNIPRPCEPLDRGLLIDLLWSDPTNKGEGWFHSIRGISYMFGKGVVEQACKSLEIDLIIRAHQVVQDGYEMMTGRRLITVFSVPNYCAQFTNAAAVVCL
.  . || |  | |.| || |.||    .|.  | || |..||   .    | |.....|| ||||.||||.. ||||.|.|| |||| |  |.|||. .
fsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfsi

NANLQISFQQM
. .|.|| . .
dkklkisinvf
PPP_2 88-279 2.3e-68 222.8 In-house 1-197 (198) alignment 
Range on Protein: 88-279
Range on HMM: 1-197/198.0
IKVIGDIHAQYQDMNRLFDLIGRVPEEKLMFLGDYVDRGPQGIEVLILLFCLKIRYRDRIYLLRGNHETPSVNKIYGFYVECQ-YKYGIGLWWDFQSCFN
..|.||.|.|..|...||.  ...||.| .||||||||| ...|||.||..||..|.....|||||||. .|||.|||. |..  |.|  ..  .|..|.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

RMPMSGLISKRVLCMHGGLSPELINLDTIRNIPRPCEPLDRGLLIDLL----WSDPTNKGEGWFHSIRGISYMFGKGVVEQACKSLEIDLIIRAHQV
 .|.. ||...||..|||||.|. .||.|... |..|  ..|.|.|||    .|||..| |.. .| ||....||. |.|. ... ...||||||.|
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 58-325 2.3e-66 217.0 In-house 5-297 (302) alignment 
Range on Protein: 58-325
Range on HMM: 5-297/302.0
VMTGHEIISIIRMVEAIFMEESNLCEAEAPIKVIGDIHAQYQDMNRLFDLIG-----------RVPEEKLMFLGDYVDRGPQGIEVLILLFCLKIRYRDR
... .|....|..|.. . .|..| |  .|. ..|||| |..|. |..                  ..| .|||||||||.. || . |.|.||. |. .
eysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptn

IYLLRGNHETPSVNKIYGFYVECQY----KYGIGLWWDFQSCFNRMPMSGLISKRVLCMHGGLSPELINLDTIRNIPRPCEPL-DRGLLIDLLWSDPTN-
  ||||||||...|  |||  | .     | |  .| .|. .|  ||.. |. ...||.|||.|| |  |. |..| || . . .  |  |||..||.. 
yillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldv

--------KGEGWFHSIRGISYMFGKGVVEQACKSLEIDLIIRAHQVVQDGYEMMTGRRLITVFSVPNYCAQFTNAAAVVCLNANLQISFQQM
        | .  .  .||.|..| .  |.. || |...||.||||..  |. ... ..|.|.|| |.|  .  |  ||. ...| ..| ...
qllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvl
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 58-325 3.8e-66 216.3 In-house 6-298 (302) alignment 
Range on Protein: 58-325
Range on HMM: 6-298/302.0
VMTGHEIISIIRMVEAIFMEESNLCEAEAPIKVIGDIHAQYQDMNRLFDLIG-----------RVPEEKLMFLGDYVDRGPQGIEVLILLFCLKIRYRDR
... .|....|..|.. . .|..| |  .|. ..|||| |..|. |..                  ..| .|||||||||.. || . |.|.||. |. .
eysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptn

IYLLRGNHETPSVNKIYGFYVECQY----KYGIGLWWDFQSCFNRMPMSGLISKRVLCMHGGLSPELINLDTIRNIPRPCEPL-DRGLLIDLLWSDPTN-
  ||||||||...|  |||  | .     | |  .| .|. .|  ||.. |. ...||.|||.|| |  |. |..| || . . .  |  |||..||.. 
yillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldv

--------KGEGWFHSIRGISYMFGKGVVEQACKSLEIDLIIRAHQVVQDGYEMMTGRRLITVFSVPNYCAQFTNAAAVVCLNANLQISFQQM
        | .  .  .||.|..| .  |.. || |...||.||||..  |. ... ..|.|.|| |.|  .  |  ||. ...| ..| ...
qllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvl
PPP_4 88-279 6e-66 215.2 In-house 1-196 (197) alignment 
Range on Protein: 88-279
Range on HMM: 1-196/197.0
IKVIGDIHAQYQDM-NRLFDLIGRVP-EEKLMFLGDYVDRGPQGIEVLILLFCLKIRYRDRIYLLRGNHETPSVNKIYGFYVECQYKYGIGLWWDFQSCF
. |.|||| |..|. ..|... |. . |....|||||||||....|||.||..||..| ....|||||||. |.|..|||. |.. |.|  ..  .| .|
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvf

NRMPMSGLISKRVLCMHGGLSPELINLDTIRNIPRPCEPL-DRGLLIDL-LWSDPTNKGEGWFHSIRGISYMFGKGVVEQACKSLEIDLIIRAHQV
. .|.. ||...||..|||||.|| .||.|..| |..|   ..... || |||||... ||. .|.||....||. |.|. ... ...||||.|..
dllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 88-280 2.8e-61 200.0 In-house 1-199 (199) alignment 
Range on Protein: 88-280
Range on HMM: 1-199/199.0
IKVIGDIHAQYQDM-NRLFDLIGRVP-EEKLMFLGDYVDRGPQGIEVLILLFCLKIRYRDRIYLLRGNHETPSVNKIYGFYVECQYK-YGIGLWWDFQSC
. |.||.| |..|.  .||. .|. . |....|||||||||....|||.||..||..| ....|||||||. ..|.||||. |.. | .|  ..  .. .
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FNRMPMSGLISKRVLCMHGGLSPELINLDTIRNIPRPCEPL-DRGLLIDL-LWSDPTNKGEG-WFHSIRGISYMFGKGVVEQACKSLEIDLIIRAHQVV
|. .|.. ||...||..|||||||. .......| |..|   ..|   || |||||... || . .|.||....||. |.|. ..  ...||||.|...
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk
subfamily_PPPLV_pd Subfamily PPPLV 66-319 4.2e-52 170.3 In-house 4-281 (290) alignment 
Range on Protein: 66-319
Range on HMM: 4-281/290.0
SIIRMVEAIFMEESNLCEAEAPIKVIGDIHAQYQDMNRLFDLIGR----VPEEKLMFLGDYVDRGPQGIEVLILLFCLKIRYRDRIYLLRGNHETPSVNK
|.  .   |...| .| | ..|. |.||.| .|.|.  . . . |    .   .|.|||||||||. ..|..  |. ||. |  ...|||||||  || .
slcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqe

IYGFYVECQYKYGIGL---WWDFQSCFNRMPMSGLISKRVLCMHGGLSPELI---NLDTIRNIPRPC-EPLDR-GLLIDLLWSDPTNK-----------G
 . .. |...|.|  |   |  |...|. .|..  | ..|.|.|.|.         . .|..|.    ...|   | .|.||||| ..            
sieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvln

EGWF-HSIRGISYMFGKGVVEQACKSLEIDLIIRAHQVVQDGYEMMTGRRLITVFSVPNYCAQFTNAAAVVCLNANLQ
||.   . || ...|..  .|.  |  ... ..|||.| . |... .. ||.||||  .|| .  .|| ..  . .|.
eGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssneaalilvdkkklr
Metallophos Calcineurin-like phosphoesterase 87-280 7.7e-39 127.0 Pfam-A 2-199 (200) alignment 
Range on Protein: 87-280
Range on HMM: 2-199/200.0
PIKVIGDIHAQYQDM----NRLFDLIGRVPEEKLMFLGDYVDRGPQGIEVLILL--FCLKIRYRDRIYLLRGNHETPSVNKIYGFYVECQ----------
.| ||||.| .. |     ..|...... .   . ||||.||||. ..|.| ||  ..||... ....||||||| ...|. |||. |.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------YKYGIGLWWDFQSCFNRMPMSGLISKRVLCMHGGLSPELINLDTIrniprpcepldrgllidllwsdptnkgegwf
                        ...|   .. .. .|...|.  |. ...|..||.||... . |.|                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

hsirgISYMFGKGVVEQACKSLEIDLIIRAHQVV
      |. ||. ..| ...   .||..|.|. .
.....gselfgpdalekllekygvdlvlrGHtHk
subfamily_PPP7C_pd Subfamily PPP7C 86-220 4.2e-28 91.1 In-house 64-201 (383) alignment 
Range on Protein: 86-220
Range on HMM: 64-201/383.0
APIKVIGDIHAQYQDMNRLFDLIGRV-PEEKLMFLGDYVDRGPQGIEVLILLFCLKIRYRDRIYLLRGNHETPSVNKIYGFYVECQYKY---GIGLWWDF
  . | ||.| . .|.  ..   |   .|.  .| ||.|||| ...|.|..|..| . |   .|| |||||   .|  |||  | . ||   |  .   .
kevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrll

QSCFNRMPMSGLISKRVLCMHGGLSpELINLDTIRNIPR
.  |  .|.. || ...| .|||.| .  .|. . .| |
edvfawlplatlidekilivhGGis.dktdlelldkier
subfamily_PPP7C_pd Subfamily PPP7C 230-325 3.5e-19 61.8 In-house 237-332 (383) alignment 
Range on Protein: 230-325
Range on HMM: 237-332/383.0
LIDLLWSDPTNKGEGWFHSIRGISYMFGKGVVEQACKSLEIDLIIRAHQVVQDGYEMMTGRRLITVFSVPNYCAQFTNAAAVVCLNANLQISFQQM
..|.||||| .|   .  ..||    ||  | ..  .  ...|.||.|.  ..|||..  ....|.||  || .. .|  | | |. .|.  . | 
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqy
subfamily_YNL217W_pd Subfamily YNL217W 88-160 5.6e-10 32.1 In-house 12-80 (235) alignment 
Range on Protein: 88-160
Range on HMM: 12-80/235.0
IKVIGDIHAQYQDMNRLFD--LIGRVPEEKLMFLGDYVDRGPQGIEVLILLfclkirYRDRIYLLRGNHETPSVN
. |.||.|. | .. .|.|   .|. ..  ....|| ...||. .||. ..       .|  . ..||||   . 
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvll
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 56-109 9.2e-09 27.9 In-house 6-59 (317) alignment 
Range on Protein: 56-109
Range on HMM: 6-59/317.0
CNVMTGHEIISIIRMVEAIFMEESNLCEAEAPIKVIGDIHAQYQDMNRLFDLIG
 .... .|.| .      .| .|    | |||....|||| |..|.  |.|| |
qdlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnG
Metallophos_2 Calcineurin-like phosphoesterase superfamily domain 89-278 1.4e-06 20.4 Pfam-A 4-118 (156) alignment 
Range on Protein: 89-278
Range on HMM: 4-118/156.0
KVIGDIHAQYQDMNRLFDLIGRvpEEKLMFLGDYVDRgpqgIEVLILLfclkiRYRdRIYLLRGNHETPSVNKIYGFYVecqykygiglwwdfqscFNRM
 .|.|.| . ...... . | .   . ....||.|..     ||. ||     .   ... .||||. . ..| . . .                 ... 
aiiSDlHgnldaleavledike..vdlilhaGDlvep....eevvell.....edi.pvlavrGnhDeaelpkelavel.................llaa

PMSGLISKRVLCMHGGLSPelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisYMFGKGVVEQACKSLEIDLIIRAHQ
  . .  .||| .||   .                                                ...  .....|. . ||.. .| 
aaleiegdrvllvhgtpls..............................................vqsseeelaellkeagadlvflGHt