Gene C09H5.7 in Caenorhabditis elegans

Synonym: CELE_C09H5.7, CELE_C09H5.7

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily CelePPP-sf4
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP015_AA protein Get Run
CeleP015_AA_30-330 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 31-329 5.6e-192 629.5 In-house 1-299 (299) alignment 
Range on Protein: 31-329
Range on HMM: 1-299/299.0
LDIDELILKVLSVGHPEKSLTKTVKEHELIQLCQMAKKSFLDQPVMLEVDAPIKVCGDVHGQYSDVIRMFSIARFPPHSNYIFLGDYVDRGRQNLELITL
||.|||..|.|.||..||.|||.|||.||..||..||..|..|...|||.|||.||||.||||||..|.|..|.|||..|..||||||||||||||||||
ldvdellskllnvgmsekrltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitl

FLCYKIKFYDRFYMLRGNHECPAVNRVYGFYEECNKRYASTRLWLAFQEAFAAMPFTGLISGRILCMHGGLSPKLTNLDVLRDLTRPMDPPSPSLHIDLL
.||.|||...||.||||||||||.||||||||||||||.|||||..||.||||||.||||..|||||||||||||..||.|||||||.|||.|||.||||
llcfkikyperffmlrgnhecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidll

WSDPDNSVIDWLPNVRGVSYIFGPNVVKKQIETLGIDLIARAHQVVQDGYEFFAEKKLVTIFSAPHYCGQFDNSAAIMNVDDNLICSFHVLRPSNRKAK
|.|||.||.|||.|||||||.||..||...|..|.|||.|||||||||||||||.|||||||||||||||||||||||.||.||.|.|.||.|.....|
wadpdqsvkdwlanvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpkslk
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 32-327 4.9e-160 524.4 In-house 2-297 (298) alignment 
Range on Protein: 32-327
Range on HMM: 2-297/298.0
DIDELILKVLSVGHPEKSLTKTVKEHELIQLCQMAKKSFLDQPVMLEVDAPIKVCGDVHGQYSDVIRMFSIARFPPHSNYIFLGDYVDRGRQNLELITLF
..|||...||||.. ||.|||..||... .|...||| | .|....|||||||||||.||||||..|.|. |.|||..||.||||||||||||||.|.|.
evdellievlsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivll

LCYKIKFYDRFYMLRGNHECPAVNRVYGFYEECNKRYASTRLWLAFQEAFAAMPFTGLISGRILCMHGGLSPKLTNLDVLRDLTRPMDPPSPSLHIDLLW
|.||.|....|..|||||||.|.||||||||||..||.|.||. .||..|.|.|.|.||.|||||||||||.||..|| ||.|.||.|....||.|||||
laykvkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllw

SDPDNSVIDWLPNVRGVSYIFGPNVVKKQIETLGIDLIARAHQVVQDGYEFFAEKKLVTIFSAPHYCGQFDNSAAIMNVDDNLICSFHVLRPSNRK
.||.|.| .| .| ||||..|| .|||...|.| |||..||||||||||||||||||||||||||||||||||||.|.||..|..||.||.|....
adpenavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpekke
subfamily_PPP1C_pd Subfamily PPP1C 51-326 1.9e-124 407.4 In-house 7-281 (282) alignment 
Range on Protein: 51-326
Range on HMM: 7-281/282.0
TKTVKEHELIQLCQMAKKSFLDQPVMLEVDAPIKVCGDVHGQYSDVIRMFSIARFPPHSNYIFLGDYVDRGRQNLELITLFLCYKIKFYDRFYMLRGNHE
. ..||.|. .|...|.. .|.||..||..||.|..||.||||.|..|.|... .||.|||.|||||||||.| || |.|.|.||||. .....||||||
evklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhe

CPAVNRVYGFYEECNKRYASTrLWLAFQEAFAAMPFTGLISGRILCMHGGLSPKLTNLDVLRDLTRPMDPPSPSLHIDLLWSDPDNSVIDWLPNVRGVSY
.  .||.||||.||..|| .. || .|...|. .|.. |.. .|||.||||||.|..|. .|...||.. |. .| .||||||||..| .|  | ||||.
sasinriyGfydeckrrysik.lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsf

IFGPNVVKKQIETLGIDLIARAHQVVQDGYEFFAEKKLVTIFSAPHYCGQFDNSAAIMNVDDNLICSFHVLRPSNR
 ||..||.| ..   .||| ||||||.|||||||...|||.||||.|||.|||..|...||..|..||..|.|...
tfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpakk
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 49-327 3.3e-122 400.0 In-house 1-278 (280) alignment 
Range on Protein: 49-327
Range on HMM: 1-278/280.0
SLTKTVKEHELIQLCQMAKKSFLDQPVMLEVDAPIKVCGDVHGQYSDVIRMFSIARFPPHSNYIFLGDYVDRGRQNLELITLFLCYKIKFYDRFYMLRGN
.|.. .|| .. .. .  || .. |  |.|||||..||||.||||.|..|.|. . ||| .||.|||||||||||.||.| | |.||... ..|..||||
tllacikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgn

HECPAVNRVYGFYEECNKRYaSTRLWLAFQEAFAAMPFTGLISGRILCMHGGLSPKLTNLDVLRDLTRPMDPPSPSLHIDLLWSDPDNSVIDWLPNVRGV
||.  .|| |||..|. .|| |  |.  ||| .  .|.. |.||||||||||||.||  || |..|.||.|..  .|. ||||.||.| |  |  | |||
hevisinrkygfkdevkrry.slalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgv

SYIFGPNVVKKQIETLGIDLIARAHQVVQDGYEFFAEKKLVTIFSAPHYCGQFDNSAAIMNVDDNLICSFHVLRPSNRK
|.||| ||||. .| | |||||| ||||||||||||.|||||.||||.|.|.||||||.. ||..|| || ||.|. |.
svifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpalre
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 62-329 7.3e-112 366.4 In-house 11-279 (284) alignment 
Range on Protein: 62-329
Range on HMM: 11-279/284.0
LCQMAKKSFLDQPVMLEVDAPIKVCGDVHGQYSDVIRMFSIARFPPHSNYIFLGDYVDRGRQNLELITLFLCYKIKFYDRFYMLRGNHECPAVNRVYGFY
|   | . |  ||...||..||..|||.|||.||..|.|    || ..||.|||||||||.. || | |...||. | ..|.||||||||  .|..||||
llfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinkiygfy

EECNKRYASTRLWLAFQEAFAAMPFTGLISGRILCMHGGLSPKLTNLDVLRDLTRPMDPPSP-SLHIDLLWSDPDNSVIDWLPNVRGVSYIFGPNVVKKQ
|||..||    .. .|.  |. ||.| |.  ||||||||.|  | |.  || . ||.| | | .| ||.||||| |    | || |||||.|| . ..| 
eecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsdalrkl

IETLGIDLIARAHQVVQDGYEFFAEKKLVTIFSAPHYCGQFDNSAAIMNVDDNLICSFHVLRPSNRKAK
.. | |||. ||||||||||||||...|||||||| |||||||.||.| |. ||.||| |||| .. |.
ldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrprkkiar
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 33-324 1.3e-110 362.3 In-house 2-295 (297) alignment 
Range on Protein: 33-324
Range on HMM: 2-295/297.0
IDELILKVLSVGHPEKSLTKTVKEHELIQLCQMAKKSFLDQPVMLEVDAPIKVCGDVHGQYSDVIRMFSIARFPPHSNYIFLGDYVDRGRQNLELITLFL
.|..|. |||    || |.| . |. ...| ..| . |  |  |.||.||||||||.|||. |..|.|    .|| .||.||||||||||  .| | |.|
vdsiiidvlsasthekllskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlll

CYKIKFYDRFYMLRGNHECPAVNRVYGFYEECNKRYASTRLWLAFQEAFAAMPFTGLISGRILCMHGGLSP---KLTNLDVLRDLTRPMDPpSPSLHIDL
.||.||   ...|||||||  ||.||||||||.||| | |.. |||. |  .|.||||. .||||||||||   |   ||.||.. |. .    .|  ||
aykvkfpgnlfllrgnhecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadl

LWSDPDNSVIDWLPNVRGVSYIFGPNVVKKQIETLGIDLIARAHQVVQDGYEFFAEKKLVTIFSAPHYCGQFDNSAAIMNVDDNLICSFHVLRPS
||.||   .  .. | ||    || . | |    . .||..|||||||||||||| .||||||||||||||||| ||.| .|..| ||| .|||.
lwadpisglsgfmenqrgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilrpt
PP2Ac_SM00156 55-323 6.7e-109 356.1 In-house 2-269 (271) alignment 
Range on Protein: 55-323
Range on HMM: 2-269/271.0
KEHELIQLCQMAKKSFLDQPVMLEVDAPIKVCGDVHGQYSDVIRMFSIARFPPHSNYIFLGDYVDRGRQNLELITLFLCYKIKFYDRFYMLRGNHECPAV
...|...|.. .|. .  .....||.||. |.||.|||..|..|... |..||...|.||||||||| |..| |.|....||.. .....||||||.. |
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

NRVYGFYEECNKRYaSTRLWLAFQEAFAAMPFTGLISGRILCMHGGLSPKLTNLDVLRDLTRPMDPPSPSLHIDLLWSDPDNSVIDWLPNVRGVSYIFGP
|..|||.||.. .| .....  |.|||...|.. |.. .||||||||||.|..|| .| |.|. ..|  .| ||||||||.... .. |. ||.|..||.
nkiygfeeevkrky.gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFge

NVVKKQIETLGIDLIARAHQVVQDGYEFFAEKKLVTIFSAPHYCGQFDNSAAIMNVDDNLICSFHVLRP
..||.  ... ..|| |||.||..||||||.||||||||||.||..|.|.||...|..|| .|...|..
davkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlke
subfamily_PPZ_pd Subfamily PPZ 31-327 1.1e-108 356.3 In-house 1-297 (300) alignment 
Range on Protein: 31-327
Range on HMM: 1-297/300.0
LDIDELILKVLSVGHPEKSLT-KTVKEHELIQLCQMAKKSFLDQPVMLEVDAPIKVCGDVHGQYSDVIRMFSIARFPPHSNYIFLGDYVDRGRQNLELIT
.||||.| |.|  |.  |      .|. |..|.|. |.. || || .||.  ..|. |||||||.|..|.|. . ||| .||.|||||||||.|.|| | 
vdideiiqklldagyaakrtknvclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletil

LFLCYKIKFYDRFYMLRGNHECPAVNRVYGFYEECNKRyASTRLWLAFQEAFAAMPFTGLISGRILCMHGGLSPKLTNLDVLRDLTRPMDPPSPSLHIDL
|.||||||. . |..|||||||  | ||||||.||..| .  ..| .| ..| ..|.. ...|.|.|.|||||| | ..| .| ..|| | |   |  ||
lllcykikypenffllrgnhecanvtrvygfydeckrr.cnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindl

LWSDPDNSVIDWLPNVRGVSYIFGPNVVKKQIETLGIDLIARAHQVVQDGYEFFAEKKLVTIFSAPHYCGQFDNSAAIMNVDDNLICSFHVLRPSNRK
||||| .|  .|  | ||||| .    ..| .. .|.||..||| ||.|||||| .. |||.|||| |||.|||  |.|.| . |.||| .| | .  
lwsdptdssnewednergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldpldsa
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 54-325 5.1e-103 337.1 In-house 8-278 (281) alignment 
Range on Protein: 54-325
Range on HMM: 8-278/281.0
VKEHELIQLCQMAKKSFLDQPVMLEVDAPIKVCGDVHGQYSDVIRMFSIARFPPHSNYIFLGDYVDRGRQNLELITLFLCYKIKFYDRFYMLRGNHECPA
. ..|.... ....  | ..  . |.|.||.| ||.|.|. |..|.| .   .|.  ..||||||||| |.||.. |....||.. || ..|||||| ..
ytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheias

VNRVYGFYEECNKRYAsTRLWLAFQEAFAAMPFTGLISGRILCMHGGLSPKLTNLDVLRDLTRPMDPPSPSLHIDLLWSDPDNSVIDWLPNVRGVSYIFG
||..||||.||  .|  . ||  ||. |  .|...||. |.|||||||||.||.|| ||.  .|....   | |||||.||||.| .|   .||.|..||
vnkiygfyvecvtkyG.eelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfG

PNVVKKQIETLGIDLIARAHQVVQDGYEFFAEKKLVTIFSAPHYCGQFDNSAAIMNVDDNLICSFHVLRPSN
 |||..   .|...|| ||||||||||| .. .||.|.||.| || .. |.||.. ||..|  |.  | |..
knvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpas
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 52-323 6.2e-103 337.1 In-house 6-282 (284) alignment 
Range on Protein: 52-323
Range on HMM: 6-282/284.0
KTVKEHELIQLCQMAKKSFLDQPVMLEVDAPIKVCGDVHGQYSDVIRMFSIARFP------PHSNYIFLGDYVDRGRQNLELITLFLCYKIKFYDRFYML
| .||.|||.||  |.. |  ... ||..||.|..||.|||. |.. .. .  .|       ...|.|||||||||   .|.|||...||... |. ..|
kllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfll

RGNHECPAVNRVYGFYEECNKRYaSTRLWLAFQEAFAAMPFTGLISGRILCMHGGLSPKLTNLDVLRDLTRPMDPPSPSLHIDLLWSDPDNSVIDWLPNV
|||||   ||. ||||.||.||| |..|. ||| || |||.. ..| .|.|||||.| .| .|. | .| ||.| |   .  || |.||...|  .    
rgnhesrpvnmqygfyleckkry.sealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesp

RGVSYIFGPNVVKKQIETLGIDLIARAHQVVQDGYEFFAEKKLVTIFSAPHYCGQFDNSAAIMNVDDNLICSFHVLRP
||   .||.. ||. ...  .||. ||||||.|||||||..||||||||| ||||.|| ||..|||..|..|| ||.|
rgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkp
0045823 Metallo-dependent phosphatases 50-330 1.1e-100 330.5 In-house 39-330 (473) alignment 
Range on Protein: 50-330
Range on HMM: 39-330/473.0
LTKTVKEHELIQLCQMAKKSFLDQPVMLEVDAPIKVCGDVHGQYSDVIRMFSIARFPPHSNYIFLGDYVDRGRQNLELITLFLCYKIKFYDRFYMLRGNH
  ....|..|..|...||. .  .| .||....| |.||.|||. | .|.. ...|||  ...||||.|||| ..|| . | |..|||. .....|||||
kegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkikypgnvfllrGNH

ECPAVNRVYGFYEECNKRYaSTRLWLAFQEAFAAMPFTGLISGRILCMHGGLSPKLTNLDVLRDLTRPMDPPSPSLHIDLLWSDPDNSVID-------WL
|. ..| .|||..|. ..| . .|. .|.| ....|.. .| |.||..|||||| |..|| .| . || ..|. .|  |||||||..   |       . 
Elrllnglygfgdetleky.gedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdPweddgdgllrlrffg

PNVRGVSYIFGPNVVKKQIETLGIDLIARAHQVVQDGYEFFAEKK------LVTIFSAPHYCGQFDNSAAIMNVDDNLiCSFHVLRPSNRKAKQ
...||..|.|||..|.. ..  |.||| |.|..|..|||..  .|      ..|.||||.|||...| ||.. .|..| .||....||. . ..
nsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsphplil
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 53-323 1.8e-97 319.2 In-house 5-274 (280) alignment 
Range on Protein: 53-323
Range on HMM: 5-274/280.0
TVKEHELIQLCQMAKKSFLDQPVMLEVDAPIKVCGDVHGQYSDVIRMFSIARFPPHSNYIFLGDYVDRGRQNLELITLFLCYKIKFYDRFYMLRGNHECP
 .  ||.| . .| .  |...  . | .||||| ||.| || |. |.| .    |  . .||||||||| | .|.. |..| ||.. || |.|||||| |
vmtgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetp

AVNRVYGFYEECNKRYAsTRLWLAFQEAFAAMPFTGLISGRILCMHGGLSPKLTNLDVLRDLTRPMDPPSPSLHIDLLWSDPDNSVIDWLPNVRGVSYIF
.||..|||| ||. .|.   ||  || .|  ||..|||| |.|||||||||.| ||| .|.. || .|    | |||||||| |    |. ..||.||.|
svnkiygfyvecqykyg.vglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymf

GPNVVKKQIETLGIDLIARAHQVVQDGYEFFAEKKLVTIFSAPHYCGQFDNSAAIMNVDDNLICSFHVLRP
|  ||.. ...| |||| |||||||||||..| ..|.|.|| | || || |.||.. .. ||  ||. | |
gkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlip
0049330 Metallo-dependent phosphatases 31-327 2.1e-97 318.9 In-house 7-302 (309) alignment 
Range on Protein: 31-327
Range on HMM: 7-302/309.0
LDIDELILKVLSVGHPEKSLTKTVKEHELIQLCQMAKKSFLDQPVMLEVDAPIKVCGDVHGQYSDVIRMFSIARFPPHSNYIFLGDYVDRGRQNLELITL
|...||||..|.. .     .|...|.||..|...||. ....| .||....| |.||.|||. | .|.. ...|||  ...||||.|||| ..|| ..|
llllelilslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlll

FLCYKIKFYDRFYMLRGNHECPAVNRVYGFYEECNKRYAsTRLWLAFQEAFAAMPFTGLISGRILCMHGGLSPKLTNLDVLRDLTRPMDPPSPSLHIDLL
 |..|... |....||||||. ..|..|||..|.  .|.  .|| .|.. ....|.. .| |.|||.|||||| |..|| .|.| ||...|  .|  |||
llalkllypdnvfllrGNHElrllnglygfgdetlrkyg.aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdll

WSDPDNSVIDWLPNVRGVSYIFGPNVVKKQIETLGIDLIARAHQVVQDGYEFFAEKKLVTIFSAPHYCGQFDNSAAIMNVDDNLICSFHVLRPSNRK
||||.. . ...||.||....||...|..  ...|.||| |.|..|..||..|...||.|.||||.|||...| .|.. .|..| .||....|....
wsdplpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpll
PPP_3 54-321 6.8e-96 313.4 In-house 2-269 (271) alignment 
Range on Protein: 54-321
Range on HMM: 2-269/271.0
VKEHELIQLCQMAKKSFLDQPVMLEVDAPIKVCGDVHGQYSDVIRMFSIARFPPHSNYIFLGDYVDRGRQNLELITLFLCYKIKFYDRFYMLRGNHECPA
..|.|| .|....|. .  .....|..||..||||.|||. |....|... ..|...|.||||||||| . || ..|.|..|||. .....||||||.  
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

VNRVYGFYEECNKRYASTRLWLAFQEAFAAMPFTGLISGRILCMHGGLSPKLTNLDVLRDLTRPMDPPSPSLHIDLLWSDPDNSVIDWLPNVRGVSYIFG
.|.||||..|. |.. ..... ..|| |...| . ||....|..||||||....|| .. |.|... |. .. .|||.|.....   . ...||....||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

PNVVKKQIETLGIDLIARAHQVVQDGYEFFAEKKLVTIFSAPHYCGQFDNSAAIMNVDDNLICSFHVL
|.|... .|.  ..||.|||.....|||.....|.||.||||.||....| .||......| ..|..|
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkql
0053225 Metallo-dependent phosphatases 38-324 1e-91 300.3 In-house 6-291 (293) alignment 
Range on Protein: 38-324
Range on HMM: 6-291/293.0
LKVLSVGHPEKSLTKTVKEHELIQLCQMAKKSFLDQPVMLEVDAPIKVCGDVHGQYSDVIRMFSIARFPPHSNYIFLGDYVDRGRQNLELITLFLCYKIK
| .|.. ..   |.|...|.||..|...||. .. .| .||....| |.||.||.. | .... ...||| ....||||.|||| ..|| ..|.|..|..
lllldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkll

FYDRFYMLRGNHECPAVNRVYGFYEECNKRYASTRLWLAFQEAFAAMPFTGLISGRILCMHGGLSPKLTNLDVLRDLTRPMDPPSPSLHIDLLWSDPDnS
. |....||||||.  .| .|||..|.  .| . .|| .... ....|.. || |.||..|||||| |..|| .|.. ||...|  .|  ||||||||  
ypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpd.l

VIDWLPNVRGVSYIFGPNVVKKQIETLGIDLIARAHQVVQDGYEFFAEKKLVTIFSAPHYCGQFDNSAAIMNVDDNLICSFHVLRPS
. .|||. ||....||...|.. ... |.||| |.||||.|||... ..||||.||||.|.|...| .|.. .|..| ..|....|.
wsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapv
PPP_1 55-310 1.6e-91 299.2 In-house 2-264 (264) alignment 
Range on Protein: 55-310
Range on HMM: 2-264/264.0
KEHELIQLCQMAKKSFLDQPVMLEVDAPIKVCGDVHGQYSDVIRMFSIARFPPHSNYIFLGDYVDRGRQNLELITLFLCYKIKFYDRFYMLRGNHECPAV
.|.||..|....|. .  ....|||...|.||||.|||. |....| .. ..|..||.||||||||| . .| ..|.|..|.|. .....||||||.  |
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

NRVYGFYEECNKRYASTRLWLAFQEAFAAMPFTGLISGRILCMHGGLSPKLTNLDVLRDLTRPMDPPSPSLHIDLL-------WSDPDNSVIDWLPNVRG
..||||..|. |.. |.... .....|. .| . || ..||..||||||.|. ||  | ..| .. |. .   |||       .||....   .  ..||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

VSYIFGPNVVKKQIETLGIDLIARAHQVVQDGYEFFAEKKLVTIFSAPHYCGQFDNSAAIMNV
..|.||..|..| ... ...||.|||.|...||||....|.||||||. |. ...| .|....
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvkl
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 51-326 3.8e-90 294.7 In-house 7-284 (287) alignment 
Range on Protein: 51-326
Range on HMM: 7-284/287.0
TKTVKEHELIQLCQMAKKSFLDQPVMLEVDAPIKVCGDVHGQYSDVIRMFSIARFPPHSNYIFLGDYVDRGRQNLELITLFLCYKIKFYDRFYMLRGNHE
............ . ... .   |..|||.|||...||.|||. |..|.|     .|. .|.||||||||| . ||.. |....||..  . ..||||||
ldafsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhe

CPAVNRVYGFYEECNKRYAsTRLWLAFQEAFAAMPFTGLISGRILCMHGGLSPKLTNLDVLRDLTRPMDPPSP--SLHIDLLWSDPDNSVIDWLPN-VRG
. ..|..|||.|| ....   ||.  |.. |. .|.   .| ||||||||.||||  || |. |..|  | .    | .||||.||..      .| .|.
vkkinklyGfkeelkrkrq.erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkira

VSYIFGPNVVKKQIETLGIDLIARAHQVVQDGYEFFAEKKLVTIFSAPHYCGQFDNSAAIMNVDDNLICSFHVLRPSNR
.| .|| ..| . ...|.|||| |||.|...||.|...|.|||.||||.|.|.  | .|.. |.. |  || ||.| . 
isvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkpedf
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 109-325 2.9e-88 289.1 In-house 101-316 (317) alignment 
Range on Protein: 109-325
Range on HMM: 101-316/317.0
SNYIFLGDYVDRGRQNLELITLFLCYKIKFYDRFYMLRGNHECPAVNRVYGFYEECNKRYaSTRLWLAFQEAFAAMPFTGLISGRILCMHGGLSPKLTNL
..|.|||||||||   .|...|....|... |. ..||||||  .||. ||||.|..||| |..|. ||| || ..|.. ... .|||||||.| .|..|
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkry.saalyeafqlafnvlplcavvnkkilcmhGGiseelldl

DVLRDLTRPMDPPSPSLHIDLLWSDPDNSVIDWLPNVRGVSYIFGPNVVKKQIETLGIDLIARAHQVVQDGYEFFAEKKLVTIFSAPHYCGQFDNSAAIM
. |  | ||.| |   .  || |.|||..|  . .  || . .||.. ||. ...| .||. ||||||.|||||||..||||||||| ||||.|| ||..
kqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavl

NVDDNLICSFHVLRPSN
.||..| .|..||||..
svdkklkisinvlrpes
subfamily_PPP2C_pd Subfamily PPP2C 51-327 2.4e-85 279.3 In-house 14-289 (290) alignment 
Range on Protein: 51-327
Range on HMM: 14-289/290.0
TKTVKEHELIQLCQMAKKSFLDQPVMLEVDAPIKVCGDVHGQYSDVIRMFSIARFPPHSNYIFLGDYVDRGRQNLELITLFLCYKIKFYDRFYMLRGNHE
.|...|.|. .||..||. .  .  . || .|. ||||||||. |.. .| |    |..||.|||||||||   .| .||. . |... .|  .||||||
ckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhe

CPAVNRVYGFYEECNKRYASTRLWLAFQEAFAAMPFTGLISGRILCMHGGLSPKLTNLDVLRDLTRPMDPPSPSLHIDLLWSDPDNSvIDWLPNVRGVSY
   . .|||||.|| ..|... .|  | . |  .|.|.|. ..|.|.||||||... || .|.| |  . |      ||||||||.    |    ||  |
srqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddr.ggwgisprgagy

IFGPNVVKKQIETLGIDLIARAHQVVQDGYEFFAEKKLVTIFSAPHYCGQFDNSAAIMNVDDNLICSFHVLRPSNRK
 || .. .|  .| |. |||||||.| .||..  ....||||||| || .  | |||...||.|  ||    |. |.
tfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpaprr
subfamily_PPP4C_pd Subfamily PPP4C 51-322 8.2e-85 277.5 In-house 13-283 (288) alignment 
Range on Protein: 51-322
Range on HMM: 13-283/288.0
TKTVKEHELIQLCQMAKKSFLDQPVMLEVDAPIKVCGDVHGQYSDVIRMFSIARFPPHSNYIFLGDYVDRGRQNLELITLFLCYKIKFYDRFYMLRGNHE
.. .||.|. .||. |.. ....  . .||.|. ||||.|||. |....| ..   |. ||.||||.||||   .| . |.|..|... || ...|||||
celikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhe

CPAVNRVYGFYEECNKRYASTRLWLAFQEAFAAMPFTGLISGRILCMHGGLSPKLTNLDVLRDLTRPMDPPSPSLHIDLLWSDPDNSViDWLPNVRGVSY
.  . .|||||.|| ..| |...|    | |  .... .| |.|.|.||||||....|| .| . |  . |     .|||||||..    |    ||  |
srqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedae.gwavsprgagy

IFGPNVVKKQIETLGIDLIARAHQVVQDGYEFFAEKKLVTIFSAPHYCGQFDNSAAIMNVDDNLICSFHVLR
.|| .||..  |. .|.||.||||.|..|| .  ..|..|..||| || .  | |||...|..|   |... 
lfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkife
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 51-324 6.3e-81 264.6 In-house 13-289 (290) alignment 
Range on Protein: 51-324
Range on HMM: 13-289/290.0
TKTVKEHELIQLCQMAKKSFLDQPVMLEVDAPIKVCGDVHGQYSDVIRMFSIARFPPHSNYIFLGDYVDRGRQNLELITLFLCYKIKFYDRFYMLRGNHE
... ........ . ... .   |..||| ||| . ||.|||  ...|.|    .||. ...||||||||| . ||.  |..||||..  . ..||||||
ldafsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhe

CPAVNRVYGFYEECNKRyASTRLWLAFQEAFAAMPFTGLISGRILCMHGGLSPKLTNLDVLRDLTRPMDPPS--PSLHIDLLWSDPDNSVIDW--LPNVR
.  |||.|||.||  ..  ..|||  .|. || ...   .. .|||||||.|.|.   . |. |..|  | .    | .||||.||..   |   |   |
vrkvnrlygfkeelark.rgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqr

GVSYIFGPNVVKKQIETLGIDLIARAHQVVQDGYEFFAEKKLVTIFSAPHYCGQFDNSAAIMNVDDNLICSFHVLRPS
..| .|| ... . ...|...|| |||.| ..|..|  .|||||.||||.|.|.  |  ||..| . |  |. ||.| 
aisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkpr
subfamily_PPP6C_pd Subfamily PPP6C 51-316 3.7e-79 258.9 In-house 12-276 (290) alignment 
Range on Protein: 51-316
Range on HMM: 12-276/290.0
TKTVKEHELIQLCQMAKKSFLDQPVMLEVDAPIKVCGDVHGQYSDVIRMFSIARFPPHSNYIFLGDYVDRGRQNLELITLFLCYKIKFYDRFYMLRGNHE
 | . | .| .||.. .. .|..  .  | .|. ||||.|||. |.  .|  .   |...|.||||.||||   || .|..|. |.|. ||  .||||||
ckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhe

CPAVNRVYGFYEECNKRYASTRLWLAFQEAFAAMPFTGLISGRILCMHGGLSPKLTNLDVLRDLTRPMDPPSPSLHIDLLWSDPDNsVIDWLPNVRGVSY
.  . .|||||.|| ..| ..  |  . . |  .. . .| ...||.||||||... || .| ..| .. |      ||.||||.. | .|    ||  |
srqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdped.vetwavsprgagy

IFGPNVVKKQIETLGIDLIARAHQVVQDGYEFFAEKKLVTIFSAPHYCGQFDNSAAIMNVDDNLIC
.|| .|.|. ...  ..||.||||.|..|.... ..||||..||| || .  | |.|....|.   
lfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeer
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 59-317 2.3e-74 243.3 In-house 25-285 (307) alignment 
Range on Protein: 59-317
Range on HMM: 25-285/307.0
LIQLCQMAKKSFLDQPVMLEVDAPIKVCGDVHGQYSDVIRMFSIARFPPHSNYIFLGDYVDRGRQNLELITLFLCYKIKFYDRFYMLRGNHECPAVNRVY
. ..   |.  |  .  ....| |  | ||.|||. |.| || .   || . |.| |||||||  .|| | |...||| . .   .||||||   ||. |
fenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkky

GFYEECNKRY--ASTRLWLAFQEAFAAMPFTGLISGRILCMHGGLSPKLTNLDVLRDLTRPMDPPSPSLHIDLLWSDPDNSVIDWLPNVRGVSYIFGPNV
||||||      .   .|  || .|  .| . ||. .|||||||||| || || ||.  .|.  |   .  |.||.||| ||..|    ||  . || ||
gfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgtnv

VKKQIETLGIDLIARAHQVVQDGYEFFAEKKLVTIFSAPHYCGQFDNSAAIMNVDDNLICS
.      ||..|| ||||.. |||  .. .||.|||||| ||  . |. ....||. |   
iddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiq
subfamily_PPP5C_pd Subfamily PPP5C 52-317 5.8e-70 228.8 In-house 32-302 (322) alignment 
Range on Protein: 52-317
Range on HMM: 32-302/322.0
KTVKEHELIQLCQMAKKSFLDQPVMLEVDAP----IKVCGDVHGQYSDVIRMFSIARFPPHS-NYIFLGDYVDRGRQNLELITLFLCYKIKFYDRFYMLR
|....   ... ..||. . ..| ..|.. .    . ||||.|||. |.. .| .   | ..  |.| ||.||||   .|.| ..|..|. . ..|.. |
kklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsr

GNHECPAVNRVYGFYEECNKRYAStRLWLAFQEAFAAMPFTGLISGRILCMHGGLSP-KLTNLDVLRDLTRPMDPPSPSLHIDLLWSDPDNSViDWLPNV
||||   .|..||| .|....|.. ..   |.| |  .|.. .|  ..| .||||   .  .|| || . | ..||. .| ..||||||...     |  
GnhesdnmnklyGfegevkakyte.kvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqean.Grspsk

RGVSYIFGPNVVKKQIETLGIDLIARAHQVVQDGYEFFAEKKLVTIFSAPHYCGQFDNSAAIMNV-DDNLICS
|||.  |||.| || ... ...|| |.|.| ..|||.  . ||.|.|||| || | .| .|.... .|.|   
rGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklk
subfamily_PPP3C_pd Subfamily PPP3C 53-315 7.6e-70 228.9 In-house 40-314 (452) alignment 
Range on Protein: 53-315
Range on HMM: 40-314/452.0
TVKEHELIQLCQMAKKSFLDQPVMLEVDAPIKVCGDVHGQYSDVIRMFSIARFPPHSNYIFLGDYVDRGRQNLELITLFLCYKIKFYDRFYMLRGNHECP
 ..|.. ... ..| | . ... .|||.||| |.||.|||. |....|...  | ...|.|||||||||   .| .  ... ||.. .....||||||| 
rleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecr

AVNRVYGFYEECNKRYaSTRLWLAFQEAFAAMPFTGLISGRILCMHGGLSPKLTNLDVLRDLTRPMDPPSPSLHIDLLWSDPDNS------VIDWLPN-V
 .   . | |||...| | ... |. |.| ..|.. |. .. ||.||||||....|| ...| |  .||.  .  ||||||| .         ...|| |
hlteyftfkeeckiky.seevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpnsv

RGVSYIFGPNVVKKQIETLGIDLIARAHQVVQDGYEFFAE------KKLVTIFSAPHYCGQFDNSAAIMNVDDNLI
|| ||... . | . ...  .  | |||.. ..||. . .        |.|.|||| |.. ..| ||......| .
rGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennvm
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 53-323 1.3e-69 227.7 In-house 5-299 (302) alignment 
Range on Protein: 53-323
Range on HMM: 5-299/302.0
TVKEHELIQLCQMAKKSFLDQPVMLEVDAPIKVCGDVHGQYSDVIRMFSIARF-----------PPHSNYIFLGDYVDRGRQNLELITLFLCYKIKFYDR
. ...||..|...  . .  .  . |. .|. . ||.|||. |..|..                  .. ..|||||||||.. .| |.| ...|. .  .
eysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptn

FYMLRGNHECPAVNRVYGFYEECNKRYASTR---LWLAFQEAFAAMPFTGLISGRILCMHGGLSPKLTNLDVLRDLTRPMDPPSP-SLHIDLLWSDPDN-
. .||||||..|.|  ||| || ..|.. .    .|  |.|.|. ||.. |.  .|||.|||.||||. |. .....||.   .. ||  |||..|| . 
yillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldv

SVI-------DWLP-NVRGVSYIFGPNVVKKQIETLGIDLIARAHQVVQDGYEFFAEKKLVTIFSAPHYCGQFDNSAAIMNVDDNLICSFHVLRP
 ..       ..   .|||.|..|    |..  . |...|| ||||..  |. |||.|||.|||||| |  . ||. |...|| |   |  |||.
qllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrn
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 52-323 1.9e-69 227.2 In-house 5-300 (302) alignment 
Range on Protein: 52-323
Range on HMM: 5-300/302.0
KTVKEHELIQLCQMAKKSFLDQPVMLEVDAPIKVCGDVHGQYSDVIRMFSIARF-----------PPHSNYIFLGDYVDRGRQNLELITLFLCYKIKFYD
|. ...||..|...  . .  .  . |. .|. . ||.|||. |..|..                  .. ..|||||||||.. .| |.| ...|. .  
keysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlypt

RFYMLRGNHECPAVNRVYGFYEECNKRYASTR---LWLAFQEAFAAMPFTGLISGRILCMHGGLSPKLTNLDVLRDLTRPMDPPSP-SLHIDLLWSDPDN
.. .||||||..|.|  ||| || ..|.. .    .|  |.|.|. ||.. |.  .|||.|||.||||. |. .....||.   .. ||  |||..|| .
nyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpld

-SVI-------DWLP-NVRGVSYIFGPNVVKKQIETLGIDLIARAHQVVQDGYEFFAEKKLVTIFSAPHYCGQFDNSAAIMNVDDNLICSFHVLRP
  ..       ..   .|||.|..|    |..  . |...|| ||||..  |. |||.|||.|||||| |  . ||. |...|| |   |  |||.
vqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrn
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 110-328 1.6e-68 224.3 In-house 121-338 (339) alignment 
Range on Protein: 110-328
Range on HMM: 121-338/339.0
NYIFLGDYVDRGRQNLELITLFLCYKIKFYDRFYMLRGNHECPAVNRVYGFYEECNKRYAsTRLWLAFQEAFAAMPFTGLISGRILCMHGGLSPKLTNLD
 |.|||||||||   .|.. |. . |. . || |.||||||  .||  |||| | | ||  ..|. .||. |  .||  .|   |.|||||.| .|| ..
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyryd.aqlyecfqnmfnvfpfcavinntimcmhggisehltsfn

VLRDLTRPMDPPSPSLHIDLLWSDPDNSVIDWLPNVRGVSYIFGPNVVKKQIETLGIDLIARAHQVVQDGYEFFAEKKLVTIFSAPHYCGQFDNSAAIMN
 .  . ||.. |   .  || |.||| .   . |  || |..|||  ..  .. | .... | ||||.||||||  ..|||||||| |||| ||.||.. 
qfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfs

VDDNLICSFHVLRPSNRKA
.| .|  |  |.||  |  
idkklkisinvfrpesrdk
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 76-325 4.8e-67 219.4 In-house 2-257 (263) alignment 
Range on Protein: 76-325
Range on HMM: 2-257/263.0
MLEVDAPIKVCGDVHGQYSDVIRMFSIARFPPHSNYIFLGDYVDRGRQNLELITLFLCYKIKFYDRFYMLRGNHECPAVNRVYGFYEECNKRYASTRL--
.||..|||..||| |||| |..|.|  .    ...|.||||||||| ..||.| |..  |. .  ....||||||  |.|. |||. | .||.    .  
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

--WLAFQEAFAAMPFTGLISGRILCMHGGLSPKLTNLDVLRDLTRPMDPP-SPSLHIDLLWSDPDNSVIDWLPN-VRGVSYIFGPNVVKKQIETLGIDLI
  .  |.. |. ||.  ..| ||||||||.||.| .|| .| .  |..   .  |  ||||.||..    . || .| .| .|| . |    . | ||||
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidli

ARAHQVVQDGYEFFAEKKLVTIFSAPHYCGQFDNSAAIMNVDDNLICSFHVLRPSN
 ||||||. || |||...|.|.||| .|  .. | ||.. |.  |  ||  |.| .
vrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkped
PPP_2 83-275 1.3e-65 213.9 In-house 1-197 (198) alignment 
Range on Protein: 83-275
Range on HMM: 1-197/198.0
IKVCGDVHGQYSDVIRMFSIARFPPHSNYIFLGDYVDRGRQNLELITLFLCYKIKFYDRFYMLRGNHECPAVNRVYGFYEECNKRYASTRLWLAFQEAFA
..||||.|||..|....|. . ..|...|.|||||||||...|| ..|.|..|... .....||||||.  ||.||||..|. |.. ..... ..|| |.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

AMPFTGLISGRILCMHGGLSPKLTNLDVLRDLTRPMDPPSPSLHIDLL----WSDPDNSVIDWLPNVRGVSYIFGPNVVKKQIETLGIDLIARAHQV
..| . ||....|..|||||.....||  .  .|... |. .. .|||    .|||...   . ...||....|||.|... .|.  ..|| |||.|
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
subfamily_PPG1_pd Subfamily PPG1 55-321 6.9e-64 209.0 In-house 15-293 (300) alignment 
Range on Protein: 55-321
Range on HMM: 15-293/300.0
KEHELIQLCQMAKKSFLDQPVMLEVDAPIKVCGDVHGQYSDVIRMFSIARFPPHSNYIFLGDYVDRGRQNLELITLFLCYKIKFYDRFYMLRGNHECPAV
 |  . .|..  |. ....  . |. .|. | ||||||. ||. .| |    | .||.|||||||||   .| |.|... |...  |  .||||||   .
pevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrqi

NRVYGFYEECNKRY-ASTRLWLAFQEAFAAMPFTGLISGRILCMHGGLSPKLTNLDVLRDLTRPMDPPSPSLHIDLLWSDPD---NSVID--------WL
 .||||| || ..|   .|.|  . | |  .  . .|   | |.||||||.   .| .. | |  . |      |||||||.   |...|        . 
tqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqhfv

PNVRGVSYIFGPNVVKKQIETLGIDLIARAHQVVQDGYEFFAEKKLVTIFSAPHYCGQFDNSAAIMNVDDNLICSFHVL
   ||  | .| .||.| ...  .. | ||||....||. . ..|| |..||| || .  | |.|... ...   | | 
vsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvy
PPP_4 83-275 2e-62 203.7 In-house 1-196 (197) alignment 
Range on Protein: 83-275
Range on HMM: 1-196/197.0
IKVCGDVHGQYSDV-IRMFSIARFPP-HSNYIFLGDYVDRGRQNLELITLFLCYKIKFYDRFYMLRGNHECPAVNRVYGFYEECNKRyASTRLWLAFQEA
. |.||.|||. |. .... .. .|. ...|.||||||||| ..|| ..|.|..|... .....||||||. ..|..|||..|. ..  . ... ..|. 
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.hgkeilkklqdv

FAAMPFTGLISGRILCMHGGLSPKLTNLDVLRDLTRPMDPP-SPSLHIDL-LWSDPDNSVIDWLPNVRGVSYIFGPNVVKKQIETLGIDLIARAHQV
|. .| . ||....|..|||||..|..|| .....|... | . ..  || ||||| ..   . ..|||....|||.|..| .|. ...|| |.|..
fdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 83-276 9.2e-62 201.5 In-house 1-199 (199) alignment 
Range on Protein: 83-276
Range on HMM: 1-199/199.0
IKVCGDVHGQYSDV-IRMFSIARFPP-HSNYIFLGDYVDRGRQNLELITLFLCYKIKFYDRFYMLRGNHECPAVNRVYGFYEECNKRYASTRLWLAFQEA
. ||||.|||. |. ...|  . .|. . .|.|||||||||...|| ..| |..|... .....||||||. ..|..|||..|. ..| . ... .... 
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FAAMPFTGLISGRILCMHGGLSPKLTNLDVLRDLTRPMDPP-SPSLHIDL-LWSDPDNSVID-WLPNVRGVSYIFGPNVVKKQIETLGIDLIARAHQVV
|  .| . ||....|..||||||.. ... |....|... | ..    || ||||| ... . .|...||....|||.|..|  |. ...|| |.|...
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk
subfamily_PPPLV_pd Subfamily PPPLV 59-313 2.4e-49 161.2 In-house 2-278 (290) alignment 
Range on Protein: 59-313
Range on HMM: 2-278/290.0
LIQLCQMAKKSFLDQPVMLEVDAPIKVCGDVHGQYSDVIRMFS-IARFP---PHSNYIFLGDYVDRGRQNLELITLFLCYKIKFYDRFYMLRGNHECPAV
|. ||..| . .... ..||...|. | ||.||.| |.| . . . |       ....|||||||||  ..|||. .|  |. .  ....||||||  .|
llslcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesv

NRVYGFYEECNKRYAST--RLWLAFQEAFAAMPFTGLISGRILCMHGGLSPKL-------TNLDVLRDLTRPMDPpSPsLHIDLLWSDPDNSVID-----
   . .. |.  ..  .    | ||...| |.| .  |  ...|.|.|.           .  |.|  |  ..|  .| | .|.|||||..   .     
qesieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidg.ap.laldilwsdpaedrdlslrge

------WLPN-VRGVSYIFGPNVVKKQIETLGIDLIARAHQVVQDGYEFFAEKKLVTIFSAPHYCGQfDNSAAIMNVDDN
      ...|  || ...|. . ... ..  ... . |||.| . |...  . .|.|.||. .|||.  |.||.. || .
lvlneGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGs.sneaalilvdkk
Metallophos Calcineurin-like phosphoesterase 82-276 1.3e-37 123.0 Pfam-A 2-199 (200) alignment 
Range on Protein: 82-276
Range on HMM: 2-199/200.0
PIKVCGDVHGQYSDV----IRMFSIARFPPHSNYIFLGDYVDRGRQNLELITLF--LCYKIKFYDRFYMLRGNHECPAVNRVYGFYEECNK---------
.| |.||.||.. |      ... ||  ..  ...||||.||||.  .| . |.  |..|.........||||||.. .| .|||..|..|         
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------RYASTRLWLAFQEAFAAMPFTGLISGRILCMHGGLSPKLTNLDVLrdltrpmdppspslhidllwsdpdnsvidwl
                         .  .. . ...| |.|.|   |. |.||..||.||. . . |                                 
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

pnvrgVSYIFGPNVVKKQIETLGIDLIARAHQVV
      |. |||... |  |  |.||. |.|. .
.....gselfgpdalekllekygvdlvlrGHtHk
subfamily_PPP7C_pd Subfamily PPP7C 53-216 1.6e-32 105.7 In-house 32-201 (383) alignment 
Range on Protein: 53-216
Range on HMM: 32-201/383.0
TVKEHELIQLCQMAKKSFLDQPVMLEVD----APIKVCGDVHGQYSDVIRMFSIARFPPHS-NYIFLGDYVDRGRQNLELITLFLCYKIKFYDRFYMLRG
... . .... . |||..   | . .|       . ||||.||.  |.. ..    .| .. .|.| ||.||||.. .|.. ..|.. . .   .|. ||
llhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrG

NHECPAVNRVYGFYEECNKRY--ASTRLWLAFQEAFAAMPFTGLISGRILCMHGGLSPKlTNLDVLRDLTR
|||   .|  |||  | ...|   ....   ... || .|.. ||  .|| .|||.| | |.|..|  . |
nhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdk.tdlelldkier
subfamily_PPP7C_pd Subfamily PPP7C 227-318 3.3e-17 55.3 In-house 238-329 (383) alignment 
Range on Protein: 227-318
Range on HMM: 238-329/383.0
IDLLWSDPDNSVIDWLPNVRGVSYIFGPNVVKKQIETLGIDLIARAHQVVQDGYEFFAEKKLVTIFSAPHYCGQFDNSAAIMNVDDNLICSF
.|.||||| .    .   .||    |||.| || ..  ...|. |.|.  ..||||  .||..|||||  |  .  |  | ... ..|   .
ldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltpri
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 51-107 4.4e-16 51.9 In-house 6-62 (317) alignment 
Range on Protein: 51-107
Range on HMM: 6-62/317.0
TKTVKEHELIQLCQMAKKSFLDQPVMLEVDAPIKVCGDVHGQYSDVIRMFSIARFPP
 . .||.|||.||  |.. |  .|..||..||....||.|||. |.. .. .  .| 
qdlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwpl
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 56-107 8.7e-10 31.2 In-house 13-64 (339) alignment 
Range on Protein: 56-107
Range on HMM: 13-64/339.0
EHELIQLCQMAKKSFLDQPVMLEVDAPIKVCGDVHGQYSDVIRMFSIARFPP
  || .||. |..    .|..|...||| | ||.|||. |.. |. .  .| 
aaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmngwpl
subfamily_YNL217W_pd Subfamily YNL217W 83-204 1.8e-08 27.2 In-house 12-139 (235) alignment 
Range on Protein: 83-204
Range on HMM: 12-139/235.0
IKVCGDVHGQYSDVIRMFS--IARFPPHSNYIFLGDYVDRGRQNLELITLFlcykikFYDRFYMLRGNHECPAVN------RVYGFYEE--CNK-RYAST
. | ||||| | ..|...   |    .    ...|| ...| ...| . .         |  . ..||||  ..       .  |. .    .|  .   
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllaykwvkkpkgaeplefsskfsfles

RLWLAFQEAFAAMPFT-GLISGRILCMHGGLSPK
.|  |  |    ..|.  . |  .| .|.||.|.
klskadmeyarelgfsldipsdellvvhaGlvpg