Gene C23G10.1 in Caenorhabditis elegans

Synonym: CELE_C23G10.1, CELE_C23G10.1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily CelePPP-sf4
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP021_AA protein Get Run
CeleP021_AA_134-437 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 153-437 4.8e-166 543.8 In-house 2-279 (280) alignment
Range on Protein: 153-437
Range on HMM: 2-279/280.0
LLACkgmtkIRTMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAQVlgGFPPDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNF
||||     |...||.|.|..||||.|.|..|||.|.||..||||||||.||.||||.|  .||||.||||||||||||...||||||.||||.||||||
llac.....ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarv..sfppdqnylflgdyvdrgrqqlevillllaykvrypnnf

MMLRGNHEVIHINEKYGFKDEVFNRkgeYHDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSEDECLENDIMWSDPA-KVSG
..||||||||.||.||||||||..|   |...||.||.|..|..||||||.||||||||||||...|||||..|||||.||||||..|..|.||. ||.|
lilrgnhevisinrkygfkdevkrr...yslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtg

WTANPRGASVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVLKPE--DI
|..|.||.||.||.|.||.....||||||.||||||||||||||.||||||||||.|...|.|||||..|...|.||||||||.  ..
waensrgvsvifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpalrev

subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 140-437 2.6e-149 489.1 In-house 2-296 (298) alignment
Range on Protein: 140-437
Range on HMM: 2-296/298.0
ESNKMFAEHFIKTLLACKGMTKIRTMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAQvlGGFPPDSNYLFLGDYVDRGSFNLEVIL
|......|.....| ..|....|...|...||...||||. |||.||.|.|...|||.||||.||.|||..  .|||||.||||||||||||..|||||.
evdellievlsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdk..agfppdanylflGdyvdrGrqnleviv

LCLAYKARYPNNFMMLRGNHEVIHINEKYGFKDEVFNRKGEYHdeLYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSEDECLEN
|.||||..|||||..||||||. .||..|||..|. .|. ...  || ||.......||.||.||||||||||||...||||.||.|.|||.|..|.|..
lllaykvkypnnffllrGnheceainrvyGfyeeckrrykslr..lyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslai

DIMWSDPAK-VSGWTANPRGASVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVLKPEDI
|..|.||.. |.||..| ||.||.|||..||.... |||||.||.||||||||||||.|||||.||||||...|.|||||.||.. |.|||||||||. 
dllwadpenavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpekk

PP2Ac_SM00156 164-435 2e-108 354.5 In-house 3-270 (271) alignment
Range on Protein: 164-435
Range on HMM: 3-270/271.0
TMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFaqVLGGFPPDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNHEVIH
. ....|.. .|.|.. .|..||...|| ..||.|||. ||.||.   |.|.||...|.|||||||||....|||||..|.| .||.....||||||  .
keevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrll..elageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsss

INEKYGFKDEVFNRKgeyHDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSEDECLENDIMWSDP-AKVSGWTANPRGASVQ
.|. |||..|| ...   ..|.| .|.|.....|| |||. .|||||||||....||||.|.|.|. ....|.|  |..||||  |..|.... ||.||.
vnkiygfeeevkrky...gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvv

FGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVLKPE
|||. |||..| ....||.|.|.||..|||||| |||||.||||.|...|.|.|||.||. .|. |.|.||..
FgedavkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq

subfamily_PPP1C_pd Subfamily PPP1C 160-436 1.1e-103 339.3 In-house 8-280 (282) alignment
Range on Protein: 160-436
Range on HMM: 8-280/282.0
TKIRTMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAQvlGGFPPDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNH
.|... .| .|..  ..|.. |  ..|.. ||.|.||.|||| ||.||| .  .|.||.|||||||||||||.. ||.|.| |||| .||.|. .|||||
vklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfet..sgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnh

EVIHINEKYGFKDEVfnrKGEYHDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSEDECLENDIMWSDPAK-VSGWTANPRG
|  .||. |||.||.   |  |. .|.  |... ...|| |||  .|||.|||||...|||...|...|| . ... |  |..|||| | | ||..| ||
esasinriyGfydec...krrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrG

ASVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVLKPED
 |..||.. |.....  |.|||||.||||.||||||| ..||||||||.|. .| |..|| .|.. | |||..|||..
vsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpak

subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 161-436 1.2e-101 332.9 In-house 23-295 (299) alignment
Range on Protein: 161-436
Range on HMM: 23-295/299.0
KIRTMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAQvlGGFPPDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNHE
 ..  .. .| ...|..|. | |..|.. |...|||.|||| ||.|.| .   |||||.|.||||||||||  |||.| | |..| .||..|.|||||||
svkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdk..agfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhe

VIHINEKYGFKDEVFNRKGeyHDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSEDECLENDIMWSDPA-KVSGWTANPRGA
.  ||  ||| .|. .|       |.  |.. ...|||. |.|.|||||||||| ....|| ||.| ||    .  |. |..|.||   | .| || || 
cpainrvygfyeecnkryk..strlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgv

SVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVLKPED
|  ||.. |..... |||||. | |||||||||||| |||||.||||||   | ||||. ||   | ..| |||| .
syvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptp

0045823 Metallo-dependent phosphatases 135-437 1.4e-95 313.7 In-house 19-326 (473) alignment
Range on Protein: 135-437
Range on HMM: 19-326/473.0
QKQSDESNKMFAEHFIKTLLACKgmtKIRTMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAQVlgGFPPDSNYLFLGDYVDRGSFN
 . ... .... . .|..|. ..   ..   |...|.. .|.|.  .....|..... ..||.|||. ||.||....  ||||. ...||||.||||...
pllfillglldldlliehlkkeg...llpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrlleki..gfppedrlvflGDlvDrGpds

LEVILLCLAYKARYPNNFMMLRGNHEVIHINEKYGFKDEVFNRKGEYhdeLYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSED
|||..|.||.| .||.|. .||||||  ..|  |||.||.. . ||    ||.||.| .. .||.|..||.||..||||| ....||..|.. ||.. .|
levlelllalkikypgnvfllrGNHElrllnglygfgdetlekyged...lyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipd

ECLENDIMWSDPAKVSG--------WTANPRGASVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKK------LVTVFSAPHYMQSFTNSAAVCK
..|  |..||||  ..|        .. .||||...||.. |.|..|  ..|||||||..|..|||.. ..|      ..||||||.|.  . | |||..
dgllldllwsdPweddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlv

VSAGLeVSFEVLKPEDI
.. .| .|| ...| . 
idedl.isfiqfdpsph

PPP_3 164-433 1.1e-94 309.5 In-house 4-270 (271) alignment
Range on Protein: 164-433
Range on HMM: 4-270/271.0
TMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAqvLGGFPPDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNHEVIH
. .. .|.. .|.|.. ....|||. || .|||.|||. ||..||    ||..|...|||||||||||.. |||.|| ||.| .||.....||||||  .
enelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfk..nggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

INEKYGFKDEVFnrKGEYHDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSEDECLENDI-MWSDPAKVSGWTANPRGASVQ
||. ||||.||.  | ......| ...|.....|| ||. ...|..|||||..|||||....|.|. ....|..  |  ..|||.| .|.. ..|||.. 
inkvYgFkkevl..kkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagll

FGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVLK
||.. ..|...  ...||.| |.....|||... .|.|||||||.|.....| .|..|... |. .|..|.
FgpdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle

subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 164-438 2.2e-92 302.0 In-house 12-285 (287) alignment
Range on Protein: 164-438
Range on HMM: 12-285/287.0
TMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAQVlgGFPPDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNHEVIH
  ||. ...  ..|.   ....|.. |. |.||.|||. ||.|.| .|  | .|. .|||||||||||.  |||.|| ...| .||..  .||||||| .
dkdilevlekieeileplpalleveapitivGdihGqlddllrifnav..GaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkk

INEKYGFKDEVFNRKGeyhDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSE--DECLENDIMWSDPAKV-SGWTAN-PRGA
||..||||.|. ....   ..|| .||.... .|| | |. ||||||||.|...||||.|. |..| .    || |  |..|.|| |   .   |  |. 
inklyGfkeelkrkrq...erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkirai

SVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVLKPEDIR
|| ||..|| ...| |||||||| |.|...||.|.. |.||||||||.|.   || .|| .||  ||.|| |||||| .
svvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkpedfe

subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 164-434 8.6e-90 294.0 In-house 25-294 (297) alignment
Range on Protein: 164-434
Range on HMM: 25-294/297.0
TMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAQvlGGFPPDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNHEVIH
   ...|. .. ..|  ||||||.. |...|||.|||.|||.||| .  ||.|| .|||||||||||| | .| |.| |||| ..| |...||||||.  
eervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhr..ggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecef

INEKYGFKDEVFNRKGEyhDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQ---HIKSLDDLRNLRRPfHSEDECLENDIMWSDPA-KVSGWTANPRGA
.|. ||| .|. .|       .|  |..... .||. |.  .|||||||||    .  .|| ||.. |. .   | |  |..|.||   .||.  | |||
vnkvygfyeecqkryqs..vrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiers.tegkerlvadllwadpisglsgfmenqrga

SVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVLKP
 . || . | ..|  ...||..| |||||||||||||.||||.||||||   | | ||.  .   |..|||.|.|
gcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilrp

0049330 Metallo-dependent phosphatases 161-437 4.3e-89 291.6 In-house 29-301 (309) alignment
Range on Protein: 161-437
Range on HMM: 29-301/309.0
KIRTMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAQVlgGFPPDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNHE
..   ....|....|.|.  .....|..... ..||.|||. ||.||....  ||||. ...||||.||||...|||.|| ||.| .||.|. .||||||
llseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrlleki..gfppedrlvflGDlvdrGpdslevlllllalkllypdnvfllrGNHE

VIHINEKYGFKDEVFNRKGeyhDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSEDECLENDIMWSDPA-KVSGWTANPRGA
  ..|  |||.||.. . |   .||..||..... .||.|..||.|||.||||| ....||..|.| ||... .. | .|..||||   ..|.. ||||.
lrllnglygfgdetlrkyg...aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpiregfapnprgl

SVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVLKPEDI
.| ||.. |.. .|....|||.|||..|..||..|...||.||||||.|.  . | .||.... .|..|| ...| ..
gvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpl

subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 166-435 5.8e-89 291.3 In-house 7-274 (284) alignment
Range on Protein: 166-435
Range on HMM: 7-274/284.0
DIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAQvlGGFPPDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNHEVIHIN
|.  |.  . .||  |  ..|.. |. ||||.|||. ||.||| .   |||  .||||||||||||   || ||| .|||  .|| |.|||||||.  ||
dvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdk..ngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslin

EKYGFKDEVFNRKGeyHDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFH-SEDECLENDIMWSDPAKV-SGWTANPRGASVQF
..||| .|.  |    .  .|  |. ..  ||| |||| ||||||||.|. .. . .|| ..|||   | . |  ||.||||...  ||  | || |  |
kiygfyeecqrryn..kpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvf

GENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVLKPE
| . ....   |.|||.|| |||||||||||| ..|||.|||| |   | |.|||  |   | .|| ||.| 
gsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrpr

0053225 Metallo-dependent phosphatases 160-433 2.3e-85 279.5 In-house 20-289 (293) alignment
Range on Protein: 160-433
Range on HMM: 20-289/293.0
TKIRTMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAQVlgGFPPDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNH
 ..   ....|.. .|.|.  .....|..... ..||.||.. ||..|....  ||||.....||||.||||...|||..|.||.|..||.|. .|||||
kllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlalleki..gfppedrlvflGDlvdrGpdslevlelllalkllypdnvvllrGNH

EVIHINEKYGFKDEVFNRKGeyHDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSEDECLENDIMWSDPAKVSGWTANPRGA
|  ..|  |||.||.. . |  ..||..|... .. .||.||.||.||..||||| .. .||..|.. ||.....| | .|..||||  .|||. ..||.
Elmllnglygfgdetlrkyg..aaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpdlwsgwlpsyrgl

SVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVLK
.| ||.. |....|. ..|||.||||||.|||... ..|||||||||.|.  ..| .|| ... || ..| ...
gvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfa

subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 164-436 1.3e-84 276.7 In-house 10-278 (281) alignment
Range on Protein: 164-436
Range on HMM: 10-278/281.0
TMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAqvLGGFPPDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNHEVIH
  .|  .|.  . ||. .|..|||| |. . ||||.|. ||.|||   | | .|.  ..|||||||||  .|||..| ...| ||... ..||||||. .
keeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfe..llgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheias

INEKYGFKDEVFNrkgEYHDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSEDECLENDIMWSDPA-KVSGWTANPRGASVQ
.| .|||  |       |  ||. .|.. .. .|. ||.  |.||||||||  . .||.|||  .| .. |  | .|..|.||  || .| |  ||.|  
vnkiygfyvecvt...kyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssft

FGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVLKPED
||.| |...|| |...||.|.||||||||| ..|.||.||||.| | . ..|.||| || . |..|.  | |. 
fGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpas

subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 162-435 3.1e-84 275.8 In-house 8-283 (284) alignment
Range on Protein: 162-435
Range on HMM: 8-283/284.0
IRTMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAqvLGGFP------PDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMML
..  ....| . ....|  .|  .||. ||.|.||.|||. ||. |.   | |.|       ...||||||||||| | .|||.| .||| ..|.. ..|
lkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalld..lngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfll

RGNHEVIHINEKYGFKDEVFNRkgeYHDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSEDECLENDIMWSDP-AKVSGWTA
|||||   .| .|||  |  .|   | . ||  |.  .  |||.|.|. .|.|||||.|... .|..| .|.||.   |  .  |. |.|| |.|.|.. 
rgnhesrpvnmqygfyleckkr...ysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegyke

NPRGASVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVLKPE
 ||||   ||.. |||..|  ..||.|| ||||.||||||| .||||.|||| |   . | ||| .|.  |..|| ||||.
sprgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkpd

PPP_1 166-421 3.5e-82 268.6 In-house 5-264 (264) alignment
Range on Protein: 166-421
Range on HMM: 5-264/264.0
DIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAQvlGGFPPDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNHEVIHIN
 ...|..  |.... .. ..|.. .. .|||.|||. ||..|| .  ||..|..||||||||||||.. .|..|| ||.| .||.....||||||  ...
elaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkv..ggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvt

EKYGFKDEVFnrKGEYHDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSEDECLENDI--------MWSDPAKVSGWTANPR
. ||||.||   | .|  |.|  . .. |..|| ||. ..||..|||||.....||. |..||  .. .|.  .|         ...|... .... ..|
kvygFkkEvl..kkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiR

GASVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKV
||. .||.. ......  ...||.| |.|...||||.. .|.||.|||. |.....| .|..|.
GagylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvkl

subfamily_PPZ_pd Subfamily PPZ 163-436 1.1e-80 264.4 In-house 26-295 (300) alignment
Range on Protein: 163-436
Range on HMM: 26-295/300.0
RTMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAQVlgGFPPDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNHEVI
.  .|... . ....|  | ...|.  .|.| ||.|||| ||.|||...  |||| .||||||||||||  .|| ||| |.|| .||.||..||||||. 
knseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkc..gfppsanylflgdyvdrgkqsletillllcykikypenffllrgnheca

HINEKYGFKDEVFNRkgeYHDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSEDECLENDIMWSDPAKVS-GWTANPRGASV
 .   ||| ||.  |      ...  | . .. .|| |.| |.|.|.|||||  ..|.|..| . ||    |  | ||..||||.  |  |  | || | 
nvtrvygfydeckrr...cnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvsy

QFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVLKPED
 . .  .... . . .||..| | ||.||||||  . |||||||| |   | |  ||  || || .|||.| | |
cynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldpld

subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 219-435 3.5e-78 256.0 In-house 101-315 (317) alignment
Range on Protein: 219-435
Range on HMM: 101-315/317.0
SNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNHEVIHINEKYGFKDEVFNRkgeYHDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIK
..||||||||||| | .||..| .|.| .||.. ..||||||   .| .|||  || .|   |  .||  |. .. ..||.|.|. .|||||||.|... 
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkr...ysaalyeafqlafnvlplcavvnkkilcmhGGiseell

SLDDLRNLRRPFHSEDECLENDIMWSDPA-KVSGWTANPRGASVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAA
.|. | .|.||..  |  .  |. |.||  .|.|.   .|||.  ||.. |||..| ||.||.||.||||.|||||||..||||.|||| |   . | ||
dlkqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaa

VCKVSAGLEVSFEVLKPE
| .|   |..|..||.||
vlsvdkklkisinvlrpe

subfamily_PPP4C_pd Subfamily PPP4C 158-433 3.6e-77 252.4 In-house 12-283 (288) alignment
Range on Protein: 158-433
Range on HMM: 12-283/288.0
GMTKIRTMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAqvLGGFPPDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRG
 .  |.  .. .| .  ..|.  .  . ..| || .|||.|||. ||..||   .||  |. |||||||.|||| . .| .|| ||.|.|||.. ...||
rcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfk..vggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirg

NHEVIHINEKYGFKDEVFNRKGEYHdeLYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSEDECLENDIMWSDPAKVSGWTANPR
|||  .| . ||| ||. .. |. .  ..    |..|...| |.. |.|.|.||||| .|..||..| . |     .|    |..|||| ...||.. ||
nhesrqitqvygfydeclrkygsan..vwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedaegwavspr

GASVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVLK
||   ||...|.....  ||.||.| ||.|..|| .   .|..||.||| |     | ||. .. . |.  |....
gagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkife

subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 161-435 7.5e-77 251.2 In-house 15-289 (290) alignment
Range on Protein: 161-435
Range on HMM: 15-289/290.0
KIRTMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAQVlgGFPPDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNHE
 .   ||. ...  ..|.    ...|.  |. | ||.|||  .|.| | .|  |.||. ..||||||||||.  ||| || . || ||...  .||||||
afsdkdileilekieeileplpalleveapivivgdihgqldallryfdav..gyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhe

VIHINEKYGFKDEVFNRKGeyhDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHS--EDECLENDIMWSDPAK--VSGWTAN-
| ..|  ||||.|.  ..|    .|.  ...... ..| | || .|||||||.||.|.| . |. |..|      || |  |..|.||..      . | 
vrkvnrlygfkeelarkrg...srlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnk

PRGASVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVLKPE
 |. || ||.. . ...| | ..|||| |.| ..|..|   ||||||||||.|    ||  |. .||  ||.|. ||||.
qraisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkpr

subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 184-439 1.6e-76 250.4 In-house 2-260 (263) alignment
Range on Protein: 184-439
Range on HMM: 2-260/263.0
MVEIDGPVRICGDLHGQYPDLIRLFAQVlgGFPPDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNHEVIHINEKYGFKDEVFNR--KGEY
..|.. |. |||| |||| ||.|.|  .  |    ..||||||||||| ..||||.| .. |   | .. .||||||.  ||..|||. |. .|  . | 
llelqapinicgdthgqyndllrifnac..gaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreev

HDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHS-EDECLENDIMWSDPAKV-SGWTANP-RGASVQFGENEVKEMCKLLDID
.. .|  ||...  |||.|.|  ||||||||.| |.|||||.| .  |. . .   |  |..|.|| |   |.  |  |  |  ||..|| ..|| ||||
yesvynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldid

LIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVLKPEDIRV
|||| ||||. || ||| ..|.||||| .|   . | |||  |   ||.||  |||||. |
livrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkpedfev

subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 163-434 4.6e-74 242.3 In-house 7-299 (302) alignment
Range on Protein: 163-434
Range on HMM: 7-299/302.0
RTMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAQV----------LGGFPpDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNF
   ... ||.   . . ..|...||  || | ||.|||..||.|....             .|   . ..||||||||||  .| | | .|.|  ||.|.
sksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfs.sdkfvflGdyvdrGsksieciclvfalkvlyptny

MMLRGNHEVIHINEKYGFKDEVFNRKGEYH-DELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSE-DECLENDIMWSDPAKVS
..||||||.  ||  |||..|. || |. .  |.. .|||..  ||| |||| .|||.|||.|....||.|.....||..   .. | .|....||. | 
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

GWTA----------NPRGASVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVLKP
. .|          . || || | |  |...|| |...||||.||..  |. ||| |||.|.|||| ||    |. || || .  ..|  ||..
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrn

subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 163-434 8.2e-74 241.5 In-house 8-300 (302) alignment
Range on Protein: 163-434
Range on HMM: 8-300/302.0
RTMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAQV----------LGGFPpDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNF
   ... ||.   . . ..|...||  || | ||.|||..||.|....             .|   . ..||||||||||  .| | | .|.|  ||.|.
sksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfs.sdkfvflGdyvdrGsksieciclvfalkvlyptny

MMLRGNHEVIHINEKYGFKDEVFNRKGEYH-DELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSE-DECLENDIMWSDPAKVS
..||||||.  ||  |||..|. || |. .  |.. .|||..  ||| |||| .|||.|||.|....||.|.....||..   .. | .|....||. | 
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

GWTA----------NPRGASVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVLKP
. .|          . || || | |  |...|| |...||||.||..  |. ||| |||.|.|||| ||    |. || || .  ..|  ||..
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrn

subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 164-435 1.7e-73 240.5 In-house 8-275 (280) alignment
Range on Protein: 164-435
Range on HMM: 8-275/280.0
TMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAqVLgGFPPDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNHEVIH
  .|  .|.. . ||  .  ..| . |... ||.| || |. |||  .. |  |. . .|||||||||   .||..| .. | || .   .||||||   
gheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfd.li.grvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetps

INEKYGFKDEVFNRkgeYHDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSEDECLENDIMWSDPA-KVSGWTANPRGASVQ
.|. |||  |.  .   |   |. .|.  .. ||. .|.  |.||||||||  .  || .||. ||    |  |  |..||||. |  ||  . || |  
vnkiygfyvecqyk...ygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisym

FGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVLKPE
||.  |.. || |.||||.|.|||||||||..||..|.|||| | |   |||.|||  . | |.|||. | | 
fgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlipp

subfamily_PPP2C_pd Subfamily PPP2C 147-434 2.7e-73 239.7 In-house 5-285 (290) alignment
Range on Protein: 147-434
Range on HMM: 5-285/290.0
EHFIKTLLACKGMTkirTMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAqvLGGFPPDSNYLFLGDYVDRGSFNLEVILLCLAYKA
...|. |  || ..     .. .|..  |.|.. .. . |.  || .|||.|||. ||. ||   .||  ||.|||||||||||| . .| . |  | | 
dklieklkeckqle...esevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfk..iggkspdtnylflgdyvdrgyysvetvtllvalkv

RYPNNFMMLRGNHEVIHINEKYGFKDEVFNRKGEyhDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSEDECLENDIMWSDP
||..   .||||||   | . ||| ||.. . |.   ...  | ...|..|| ||| ..|.|.||||| .|..||..|.| |     .|    |..||||
rykeritilrgnhesrqitqvygfydeclrkygn..anvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdp

AKVSGWTANPRGASVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVLKP
   .||.  ||||  .||..  ... |  .. ||.| ||.| .||..   ...||.|||| |     | ||. ..   |. ||   .|
ddrggwgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdp

subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 168-442 2.6e-72 236.6 In-house 26-299 (307) alignment
Range on Protein: 168-442
Range on HMM: 26-299/307.0
FRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFaqVLGGFPPDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNHEVIHINEK
  .|. .. ||. .|..|.|| |. . ||||||. ||| .|  .| | ||.. |.| ||||||| ..||.||| ..||  ||.| ..||||||. ..|.|
enviyeaqtifssekalvdidppcvvvgdlhgqfndlinmf..illgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkk

YGFKDEVFNRKGEYHDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSEDECLENDIMWSDPA-KVSGWTANPRGASVQFGEN
||| .|.        .|..  |.  .. .|. ||.  .|||||||||  .  ||.|||  .|       . ||..|.||   |  | |  ||. . || |
ygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgtn

EVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVLKPEDIRVEEI
 . ..|| | ..||.| ||.. |||  ..|.||.|.|||| | . . |. .| ||   | .    . ||   .|.|
viddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpesenieki

subfamily_PPP6C_pd Subfamily PPP6C 148-426 5.5e-70 228.8 In-house 4-275 (290) alignment
Range on Protein: 148-426
Range on HMM: 4-275/290.0
HFIKTLLACKGMTKirtMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAQvlGGFPPDSNYLFLGDYVDRGSFNLEVILLCLAYKAR
..|..   || ...    |. .| .. ....  . ... .  || .|||.|||. ||  || .  ||  ||..|.||||.|||| . || . . |. ||.
kwielakkckylpe...ndlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrt..ggqvpdtsyvflgdfvdrgyysletftrlltlkak

YPNNFMMLRGNHEVIHINEKYGFKDEVFNRKGEYHDELYpeFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSEDECLENDIMWSDPA
||.. ..||||||  .| . ||| || .|. |.     |  . ...|.... |.. ...||.||||| ..| ||..| . |  .   .    |..|||| 
ypdritllrgnhesrqitqvygfydeclnkygnanawky..ctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpe

KVSGWTANPRGASVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLE
.|. |.  ||||   ||.. .||.... ...||.| ||.|..|....  .|||||.||| |     | |.. ...   |
dvetwavsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaee

subfamily_PPP5C_pd Subfamily PPP5C 140-430 1.3e-68 224.4 In-house 12-304 (322) alignment
Range on Protein: 140-430
Range on HMM: 12-304/322.0
ESNKMfAEHFIKTLL-ACKGMTKIRTMDIFRLIHICKKIFTVQKSMVEIDGP----VRICGDLHGQYPDLIRLFaQVLGGFPPDSNYLFLGDYVDRGSFN
|..|. ...|.| ||   |   |...  .....   |...  . |.|||. .    . .|||.|||. ||. .| .. |   ..  ||| ||.|||||| 
eeeki.tkefvkellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnif.elnGlpseenpylfnGdfvdrGsfs

LEVILLCLAYKARYPNNFMMLRGNHEVIHINEKYGFKDEVfnrKGEYHDELYPEFNEMMDMMPLVALVGGRILCMHGGLS-QHIKSLDDLRNLRRPFHSE
.||||. |..|  |||.| . ||||| ...|. |||..||   |  | ....  |.|. ...||  ..  ..| .||||  ..  .|||||.. |  .  
veviltllgfkllyPnhfflsrGnhesdnmnklyGfegev...kakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqpp

DECLENDIMWSDPAKVSGWTANPRGASVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKV-SAGLEVSFE
.| |  ...|||| . .| ..  || .|||| .  |...|  ...||.| |.| ..|||.    ||.|||||| | .. .| .|. .. .. |.. |.
eegllvellwsdpqeanGrspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfk

subfamily_PPP3C_pd Subfamily PPP3C 128-422 3.2e-67 220.3 In-house 14-310 (452) alignment
Range on Protein: 128-422
Range on HMM: 14-310/452.0
GARDKMFQKQSDESNKMFAEHFIKTllackgmTKIRTMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAqvLGGFPPDSNYLFLGDY
 . ...|....    ... |||.|         .. . .. ..|. . |..  .|...|.. |. ..||.|||. ||..||   .|| | ...|||||||
lteeevfdetgkpklevlkehflke.......grleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfe..vgGdPastkylflGdy

VDRGSFNLEVILLCLAYKARYPNNFMMLRGNHEVIHINEKYGFKDEVFNRkgeYHDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLR
||||.| .|..|  .| |  ||.....||||||  |. | . ||.|.  .   |  |.| .. | .|..|| ||. .. ||.||||| .||||||...| 
vdrGyfsiecvlylyalkiaypstlfllrGnhecrhlteyftfkeeckik...yseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkld

RPFHSEDECLENDIMWSDPAKVSGWTA--------NPRGASVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAG------KKLVTVFSAPHYMQSFT
|    .   .  |..||||..  | ..        ..|| |. .. . | |. .  |.  |.| |.. ..||. .          |.|.|||| |.....
rfkeppasGplcdllWsdPledygeekteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvyn

NSAAVCKVS
| ||| |. 
nkaavlkye

PPP_2 191-386 3.5e-67 218.9 In-house 1-197 (198) alignment
Range on Protein: 191-386
Range on HMM: 1-197/198.0
VRICGDLHGQYPDLIRLFAqvLGGFPPDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNHEVIHINEKYGFKDEVFnrKGEYHDELYPEFN
|..|||||||. ||..||    |...|...|||||||||||...|||.||.||.| .||.....||||||  ..|. ||||.||.  | ......| ...
vtvcGDlHGqldDLlilfk..nglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevl..kkkggkkvykklq

EMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSEDECLENDI-----MWSDPAKVSGWTANPRGASVQFGENEVKEMCKLLDIDLIVRGHQ
|.....|| ||. ...|..|||||..||.||. .. .|. .|..|.. .|      ......| .... . |||.. ||.. ..|...  ...||.| |.
evfelLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHe

V
|
v

PPP_4 191-386 9.5e-66 214.6 In-house 1-196 (197) alignment
Range on Protein: 191-386
Range on HMM: 1-196/197.0
VRICGDLHGQYPDLIRLFAQvLGGFPP-DSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNHEVIHINEKYGFKDEVFNRkgeYHDELYPEF
| ..||.|||. ||.  . . .||.|. ...|.|||||||||...|||.|| ||.| .||.....||||||  ..|. ||||.|| ..   ...|.. ..
vtvvGDiHGqlddlllkllk.ngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek...hgkeilkkl

NEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSE-DECLENDI-MWSDPA-KVSGWTANPRGASVQFGENEVKEMCKLLDIDLIVRGHQV
....|..|| ||. ...|..|||||....|||......|...|. .|.. .|. .||||. . .|.. . |||.. ||.. ......  ...||.|.|..
qdvfdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel





PPP_5_Dcr2 191-387 5.4e-64 208.8 In-house 1-199 (199) alignment
Range on Protein: 191-387
Range on HMM: 1-199/199.0
VRICGDLHGQYPDLIRLFAQVLgGFPP-DSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNHEVIHINEKYGFKDEVFNRKgeYHDELYPEF
| .|||||||. ||.  . .   |.|. . .|.|||||||||...|||.|| ||.| .||.....||||||  ..|| |||..|| ..   .. ..|  .
vtvcGDlHGqlddlllilfkeg.gdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlsky..hgkkiykil

NEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSE-DECLENDI-MWSDPA-KVSG-WTANPRGASVQFGENEVKEMCKLLDIDLIVRGHQ
....|..|| ||. ...|..|||||..|||...|....|..... ..  ..|. .||||. ...| .. . |||.. ||.. ......  ...||.|.|.
sdvfdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshe

VV
..
lk

subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 220-436 1.6e-61 201.3 In-house 121-335 (339) alignment
Range on Protein: 220-436
Range on HMM: 121-335/339.0
NYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNHEVIHINEKYGFKDEVFNRkgeYHDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKS
 ||||||||||| | .||..|  | |  ||.   .||||||   .|  |||  ||  |   |  .||  |..|....|..|..   |.|||||.|.|. |
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyr...ydaqlyecfqnmfnvfpfcavinntimcmhggisehlts

LDDLRNLRRPFHSEDECLENDIMWSDPAKV-SGWTANPRGASVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAV
....  ..||.   |  .  |. |.||     |.    ||||. ||   .. . | ||.....||||||.|||||| |..|||.|||| |     |.|||
fnqfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaav

CKVSAGLEVSFEVLKPED
  .   |..| .|..|| 
fsidkklkisinvfrpes

subfamily_PPG1_pd Subfamily PPG1 170-432 2.6e-57 187.3 In-house 22-293 (300) alignment
Range on Protein: 170-432
Range on HMM: 22-293/300.0
LIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAqvLGGFPPDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNHEVIHINEKYG
|..  |...  .  ..||  || . ||.|||. |.. .|   .||  ||.|||||||||||| . .| | | .. | |||    .||||||   | . ||
ltdklkellvkesnvieirspvtvvgdvhgqfydvleifk..iggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrqitqvyg

FKDEVFNRKGEyHDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLRNLRRPFHSEDECLENDIMWSDPA----------KVSG--WTANPR
|  |.... |     ..  . |..| . |.|..   | |.|||||  ..|.|... | |     .|    |..||||             .|  ..  .|
fyteclrkygg.nsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqhfvvsqr

GASVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGLEVSFEVL
||   .|.. |... .  |.. |.| ||....||. .  .|| ||.||| | .   | |.. ..   .|  |.| 
gagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvy

subfamily_PPPLV_pd Subfamily PPPLV 173-422 2e-47 154.9 In-house 8-276 (290) alignment
Range on Protein: 173-422
Range on HMM: 8-276/290.0
ICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIrLFAQVLGG---FPPDSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNHEVIHINEKYG
.  .|.  .. ..|.. |. . |||||.| |||  |..||         ...|||||||||| |..|.|   || |  ||  ...||||||.  . |.. 
vavdilaaeerllelksptyvlgdlhgnyrdli.yfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqesie

FKDEVFNRKGEYHDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDD---LRNLRR--PFHSEDECLENDIMWSDPAK------------VSGW
.| | . . |.  .| .  ||...|..|| | .  ...|.|.|. . |..      ....    . . .   |  ||.|||||.              |.
ykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvlneGf

TANP-RGASVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSfTNSAAVCKVS
  |  || .  |.|. .. . |  ... ..| |.| . |...  . .|.||||. .|  | .|.||.  |.
vdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGs.sneaalilvd

Metallophos Calcineurin-like phosphoesterase 190-387 1.4e-39 129.5 Pfam-A 2-199 (200) alignment
Range on Protein: 190-387
Range on HMM: 2-199/200.0
PVRICGDLHGQYPDL--IRLFAQVLGGFPPDSNYLFLGDYVDRGSFNLEVILLC--LAYKARYPNNFMMLRGNHEVIHINEKYGFKDEVFN---------
.. ..|||||.. ||  ..|  . ... ..  ..|||||.||||   .|.. |   |..| ..|.....||||||. ..|. |||..|...         
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

----------------------RKGEYHDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHIKSLDDLrnlrrpfhsedeclendimwsdpakvsgwta
                       .... |. . |..|  . .|| |||.|.||..||.|| . .| ||                                
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

nprgASVQFGENEVKEMCKLLDIDLIVRGHQVV
    .|. ||.... . ..  ..||..|||. .
....gselfgpdalekllekygvdlvlrGHtHk

subfamily_PPP7C_pd Subfamily PPP7C 168-328 4.1e-32 104.4 In-house 39-201 (383) alignment
Range on Protein: 168-328
Range on HMM: 39-201/383.0
FRLIHICKKIFTVQKSM----VEIDGPVRICGDLHGQYPDLIRLFAQvlGGFPP-DSNYLFLGDYVDRGSFNLEVILLCLAYKARYPNNFMMLRGNHEVI
  ... .||..   ...      |   | .||||||.  ||. .. .   |.|  . .|.| ||.||||.  .|..|. ||.   ||... . |||||  
llilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyk..nGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedh

HINEKYGFKDEVFNRKGEYHDELYPEFNEMMDMMPLVALVGGRILCMHGGLSQHiKSLDDLRNLRR
 .| .|||  || ..  ... ..   ....   .|| .|.  .|| .|||.|..  .|. | .. |
ilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdk.tdlelldkier

subfamily_PPP7C_pd Subfamily PPP7C 340-425 5.9e-17 54.4 In-house 239-325 (383) alignment
Range on Protein: 340-425
Range on HMM: 239-325/383.0
DIMWSDPAKVSGWTANP-RGASVQFGENEVKEMCKLLDIDLIVRGHQVVQDGYEFFAGKKLVTVFSAPHYMQSFTNSAAVCKVSAGL
||.|||| . .| ..|  ||. . || .  |.. .  ...|..| |.  ..||||   ||..|.|||  | .  .|  |  |..  |
dilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdl

subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 161-216 1.5e-08 27.2 In-house 8-61 (317) alignment
Range on Protein: 161-216
Range on HMM: 8-61/317.0
KIRTMDIFRLIHICKKIFTVQKSMVEIDGPVRICGDLHGQYPDLIRLFAqvLGGFP
 ... ..  | .  ...|  .. ..|.. || |.||.|||. ||. |.   | |.|
lfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalld..lnGwp

subfamily_YNL217W_pd Subfamily YNL217W 193-266 4.9e-08 25.8 In-house 14-81 (235) alignment
Range on Protein: 193-266
Range on HMM: 14-81/235.0
ICGDLHGQYPDLIRLFAQVLGGFPPDSNYLFLGDYVDRGSFNLEVILLClaykarYPNNFMMLRGNHEVIHINE
. || || | .||.|. .  ||  ..   ...|| ...|  ..||. .         ..   ..|||| . . .
vvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvlla

Metallophos_2 Calcineurin-like phosphoesterase superfamily domain 193-385 8.1e-07 21.2 Pfam-A 5-118 (156) alignment
Range on Protein: 193-385
Range on HMM: 5-118/156.0
ICGDLHGQYPDLIRLFAQVlGGfppDSNYLFLGDYVDRgsfnLEVILLClaykARYpnNFMMLRGNHEVIHINEKYGFKDevfnrkgeyhdeLYPEFNEM
| .||||.  .| .. ...  .      .|..||.|..     ||. |     ...  .. ..||||.  ...... ..             |...... 
iiSDlHgnldaleavledi.ke...vdlilhaGDlvep....eevvell....edi..pvlavrGnhDeaelpkelavel............llaaaale

MDmmplvalvGGRILCMHGGLSQhikslddlrnlrrpfhsedeclendimwsdpakvsgwtanprgasVQFGENEVKEMCKLLDIDLIVRGHQ
..        | |.| .||   .                                             ||..|.|..| .|  . ||.. || 
ie........gdrvllvhgtpls.............................................vqsseeelaellkeagadlvflGHt

UCH Ubiquitin carboxyl-terminal hydrolase 31-134 2.4e-06 13.1 Pfam-A 4-88 (269) alignment
Range on Protein: 31-134
Range on HMM: 4-88/269.0
LINDGTSCFLNIILQMLKR-ANFHDHFKGD----WQKGKQKMLMHKElqqifngkpgpkdvsrlremfsnealkdgphpLLVALKCLI--------KMSA
|.| | .|..| .||.|    .| . .. .    ... .... ...|                                |. ||. |.        . .|
leNlGntCYmnsvlQcLvnipefreylleekyeeeknessslgeege................................laraladlfekltsnksrkka

VSDNDVIKEKGARDKMF
|| . ..|  .. .|.|
vspkefkktlsklnkef