Gene C24H11.1 in Caenorhabditis elegans

Synonym: CELE_C24H11.1, C24H11.1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily CelePPP-sf3
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP024_AA protein Get Run
CeleP024_AA_104-367 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 106-368 3.7e-192 629.5 In-house 1-263 (263) alignment 
Range on Protein: 106-368
Range on HMM: 1-263/263.0
ALLELQAPINICGDTHGQYNDLLRIFNACGAATKTQYLFLGDYVDRGGHSLEVIMLLFSLKLAMPRKMHLLRGNHELKAINKNYGFHAELKKRFQREEVY
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
allelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevy

ESVYNHFNQVFSYMPLCAIVSKRILCMHGGISPHLKSLDDIRAIPLPLETAKTHPLACDLLWADPEKDAKGFEPNKIRAISNVFGKKEVDDLCKRLDIDL
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
esvynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidl

IVRAHQVVEYGYAFFADRRLITVFSASRYQIELCNYAAVVVVNKMLELSFVQLKPEDFEVRRD
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ivrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkpedfevrrd
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 104-366 9.6e-143 467.3 In-house 29-287 (287) alignment 
Range on Protein: 104-366
Range on HMM: 29-287/287.0
ANALLELQAPINICGDTHGQYNDLLRIFNACGAATKTQYLFLGDYVDRGGHSLEVIMLLFSLKLAMPRKMHLLRGNHELKAINKNYGFHAELKKRFQree
 .||||..|||.|.||.|||..||||||||.|||.|.||||||||||||..||||..||||||.|.|.|.||||||||.|.|||.|||..|||...|   
lpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkkinklyGfkeelkrkrq...

vyESVYNHFNQVFSYMPLCAIVSKRILCMHGGISPHLKSLDDIRAIPLPLETAKT-HPLACDLLWADPEKDAKGFEPNKIRAISNVFGKKEVDDLCKRLD
  |..|..||.|||..||||.||||||||||||||.|||||...|...|    .  . |  ||||||||||||.||.|||||||.||||||||||.|.||
..erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisvvfGkkevddllkkld

IDLIVRAHQVVEYGYAFFADRRLITVFSASRYQIELCNYAAVVVVNKMLELSFVQLKPEDFEVR
||||||||.|.|.||||..|.||.|||||..|..| .|..|||||.|.||||||.|||||||||
idlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkpedfevr
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 105-362 2e-104 341.8 In-house 44-295 (298) alignment 
Range on Protein: 105-362
Range on HMM: 44-295/298.0
NALLELQAPINICGDTHGQYNDLLRIFNACGAATKTQYLFLGDYVDRGGHSLEVIMLLFSLKLAMPRKMHLLRGNHELKAINKNYGFHAELKKRFQREEv
..|.|..|||..||| ||||.||||.|. .|   .. ||||||||||| ..||||.||.. |.  | .. ||||||| .|||..|||. | |.|... . 
kslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnffllrGnheceainrvyGfyeeckrrykslr.

yesVYNHFNQVFSYMPLCAIVSKRILCMHGGISPHLKSLDDIRAIPLPLETAKThPLACDLLWADPEKDAKGFEPNKiRAISNVFGKKEVDDLCKRLDID
   .|..|..||. .||.|....||||||||.|..|||||..|..  | .. ..  || ||||||||.  ||...|. | .| |||...| ||...||||
...lyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskee.slaidllwadpenavkgwaens.rGvsvvfGedvvkdllekldid

LIVRAHQVVEYGYAFFADRRLITVFSASRYQIELCNYAAVVVVNKMLELSFVQLKPED
|.|||||||  || |||...|.|.||| .|  .. | |||. |.. |..||. ||||.
lvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpek
subfamily_PPP1C_pd Subfamily PPP1C 105-362 2.3e-99 325.2 In-house 30-280 (282) alignment 
Range on Protein: 105-362
Range on HMM: 30-280/282.0
NALLELQAPINICGDTHGQYNDLLRIFNACGAATKTQYLFLGDYVDRGGHSLEVIMLLFSLKLAMPRKMHLLRGNHELKAINKNYGFHAELKKRFQREev
 .||||.||..|.|| ||||.||||.|...|| ....||||||||||| .|||.|.||...|.  | ...||||||| . ||. |||. | |.|.. .  
pilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesasinriyGfydeckrrysik..

yesVYNHFNQVFSYMPLCAIVSKRILCMHGGISPHLKSLDDIRAIPLPLETAKThPLACDLLWADPEKDAKGFEPNKiRAISNVFGKKEVDDLCKRLDID
   ....|..||...||.|.|...|||.|||.||.||||..|| |  ||| ...  |.|||||.||.|. .|.. |. | .| .|||. |...... |.|
...lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpek.gllcdllWsdpdkevlgwsend.rGvsftfgkdvvekflqkndld

LIVRAHQVVEYGYAFFADRRLITVFSASRYQIELCNYAAVVVVNKMLELSFVQLKPED
|||||||||| || |||.|.|.|||||. |  |. | .||. |.. | .||  |||..
livrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpak
PP2Ac_SM00156 105-361 2.6e-97 318.1 In-house 21-270 (271) alignment 
Range on Protein: 105-361
Range on HMM: 21-270/271.0
NALLELQAPINICGDTHGQYNDLLRIFNACGAATKTQYLFLGDYVDRGGHSLEVIMLLFSLKLAMPRKMHLLRGNHELKAINKNYGFHAELKKRFqreev
..|.|..||. ..||.|||..||||...  |  ....|.||||||||| .|.|||.|||.||.. | |..||||||| . .|| |||  |.| .      
knlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssvnkiygfeeevkrky.....

YESVYNHFNQVFSYMPLCAIVSKRILCMHGGISPHLKSLDDIRAIPLpLETAKTHPLACDLLWADPEKDAKGFEPNKiRAISNVFGKKEVDDLCKRLDID
 ...|. |...||..||.|.|...|||||||.||.|.|||||| .    ..   ..|..||||.|||.. |||.|.| | .| |||.. |....|.....
gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkr.vkekpeegllidllwsdpeqkekgfqpsk.rglsvvFgedavkeflkknnlk

LIVRAHQVVEYGYAFFADRRLITVFSASRYQIELCNYAAVVVVNKMLELSFVQLKPE
||.|||.||. || ||||..|.|.|||..|. |  |.|||. |.| |.||..|||..
liiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 105-366 1.9e-96 315.5 In-house 26-280 (280) alignment 
Range on Protein: 105-366
Range on HMM: 26-280/280.0
NALLELQAPINICGDTHGQYNDLLRIFNACGAATKTQYLFLGDYVDRGGHSLEVIMLLFSLKLAMPRKMHLLRGNHELKAINKNYGFHAELKKRfqreeV
....|..||...||| ||||.||||.|. ..    ..||||||||||| . ||||.||.. |.  | .. .||||||   ||..|||. | |.|      
atmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisinrkygfkdevkrr.....y

YESVYNHFNQVFSYMPLCAIVSKRILCMHGGISPHLKSLDDIRAIPLPLETAkTHPLACDLLWADPEKDAKGFEPNKiRAISNVFGKKEVDDLCKRLDID
 ...||.|....  .||.|.|| ||||||||.|..|.||||.. .  |...   . || ||||||||..  |.  |  | .| .||...| ||...||||
slalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdse.declamdllwadpenkvtgwaens.rgvsvifganvvkdltekldid

LIVRAHQVVEYGYAFFADRRLITVFSASRYQIELCNYAAVVVVNKMLELSFVQLKPEDFEVR
||.| ||||. || ||||..|.||||| .|  |. | |||..|.. |..||  |||.  ||.
liarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpalrevk
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 106-367 2.4e-88 289.3 In-house 24-280 (284) alignment 
Range on Protein: 106-367
Range on HMM: 24-280/284.0
ALLELQAPINICGDTHGQYNDLLRIFNACGAATKTQYLFLGDYVDRGGHSLEVIMLLFSLKLAMPRKMHLLRGNHELKAINKNYGFHAELKKRFQREevy
 |.| ..||||||| |||. ||||.|.  |   ...||||||||||| | || |.|||. |. .| .. .||||||   ||| |||. | ..|...    
mlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinkiygfyeecqrrynkp...

eSVYNHFNQVFSYMPLCAIVSKRILCMHGGISPHLKSLDDIRAIPLPLETAKTHPLACDLLWADPEKDAKGFEPNKiRAISNVFGKKEVDDLCKRLDIDL
 |||  |. ||| ||| |.| .||||||||.|  |. . ..|||  |..  .   || |.||.|| .  ||..||  | .| |||   .  |  ||.|||
.svyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpns.rgvsyvfgsdalrklldrlqidl

IVRAHQVVEYGYAFFADRRLITVFSASRYQIELCNYAAVVVVNKMLELSFVQLKPEDFEVRR
.|||||||. || |||.|||.|.|||  |  .. | |||. ||| |  ||| |.|     ||
vvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrprkkiarr
PPP_3 105-359 1.4e-87 286.1 In-house 22-270 (271) alignment 
Range on Protein: 105-359
Range on HMM: 22-270/271.0
NALLELQAPINICGDTHGQYNDLLRIFNACGAATKTQYLFLGDYVDRGGHSLEVIMLLFSLKLAMPRKMHLLRGNHELKAINKNYGFHAELKkrfqREEV
. |.|..||...|||.|||..|||..|. .|   .|.||||||||||| .||||..||..||. .|...|||||||| . ||| |||. |..    ... 
snlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrqinkvYgFkkevl....kkkg

YESVYNHFNQVFSYMPLCAIVSKRILCMHGGISPHLKSLDDIRAIPLPLETaKTHPLACDLLWADPEKDAKGFEPNkIRAISNVFGKKEVDDLCKRLDID
 ..||.....||...||.|......|..|||.||..||||.|. .  . |. ... . .|||. ..... .|.|..  | .. .||.. ....... ...
gkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkiev.peegklldlllssdpekeeglens.krGagllFgpdvteefleknkLk

LIVRAHQVVEYGYAFFADRRLITVFSASRYQIELCNYAAVVVVNKMLELSFVQLK
||.|||...| || ...|....|||||. |  .  | .|.. ... |. .|.||.
liiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
0045823 Metallo-dependent phosphatases 105-367 3.7e-87 285.9 In-house 63-330 (473) alignment 
Range on Protein: 105-367
Range on HMM: 63-330/473.0
NALLELQAPINICGDTHGQYNDLLRIFNACGAATKTQYLFLGDYVDRGGHSLEVIMLLFSLKLAMPRKMHLLRGNHELKAINKNYGFHAELKKRFQREev
. ||||...| ..|| |||. ||||... .|   .....||||.|||| .||||. ||..||.. | ...||||||||...|  |||. |. ... ..  
pnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkikypgnvfllrGNHElrllnglygfgdetlekyged..

yesVYNHFNQVFSYMPLCAIVSKRILCMHGGISPHLKSLDDIRAIPLPLETAKtHPLACDLLWADPeKDAKG--------FEPNKiRAISNVFGKKEVDD
   .|..|.......||.|.. ..||..|||.||.|..||.||.|. |||  . ..|..||||.||  . .|        |.... | .. .||.. |..
...lyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipd.dgllldllwsdP.weddgdgllrlrffgnsp.rgagylFgpdavee

LCKRLDIDLIVRAHQVVEYGYAFFADRR------LITVFSASRYQIELCNYAAVVVVNKMLeLSFVQLKPEDFEVRR
..|. ..|||||.|..|. || .. |..      .||||||. |  .  | |||.|... | .||.|..| . ....
flkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsphplil
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 105-361 3.2e-85 278.6 In-house 36-289 (290) alignment 
Range on Protein: 105-361
Range on HMM: 36-289/290.0
NALLELQAPINICGDTHGQYNDLLRIFNACGAATKTQYLFLGDYVDRGGHSLEVIMLLFSLKLAMPRKMHLLRGNHELKAINKNYGFHAELKKRfqREev
 ||||..||| | || ||| ..||| |.| |   | ..|||||||||| .|||| .||| .|. ...|.|||||||| . .|. |||. || ..  |.  
palleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrkvnrlygfkeelark..rg..

yESVYNHFNQVFSYMPLCAIVSKRILCMHGGISPHLKSLDDIRAIPLPLET-AKTHPLACDLLWADPEK-DAKGFEPNKIRAISNVFGKKEVDDLCKRLD
   ... ...||. ..||| |...|||||||||....| . ..|.  |       . |  |||||||..  .. .. || |||| ||||| .|||.|.| 
.srlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqraisvvfgkkglddllkkla

IDLIVRAHQVVEYGYAFFADRRLITVFSASRYQIELCNYAAVVVVNKMLELSFVQLKPE
..||||||.| | |..|  |..|.|||||  |  . .|  |.. | . ||||.| |||.
lslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkpr
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 105-362 4.3e-85 278.5 In-house 44-295 (299) alignment 
Range on Protein: 105-362
Range on HMM: 44-295/299.0
NALLELQAPINICGDTHGQYNDLLRIFNACGAATKTQYLFLGDYVDRGGHSLEVIMLLFSLKLAMPRKMHLLRGNHELKAINKNYGFHAELKKRFQREEV
..|||..||| .||| |||| ||||||.  |   ....||||||||||   ||.|.||.  |. .| ....||||||  |||. |||. | .||..   .
aslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecpainrvygfyeecnkrykstrl

yesvYNHFNQVFSYMPLCAIVSKRILCMHGGISPHLKSLDDIRAIPLPLETAKtHPLACDLLWADPEKDAKGFEPNkIRAISNVFGKKEVDDLCKRLDID
    .  |.. |..|||. ... ||||||||.||.|..|| .| .. | .  .   |  |||||||..  |.. .| .| .| |||.. | | ..|||||
....wsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppn.pslgidllwadpdqsvkdwlan.vrgvsyvfgqdvvadvisrldid

LIVRAHQVVEYGYAFFADRRLITVFSASRYQIELCNYAAVVVVNKMLELSFVQLKPED
|. ||||||. || |||...|.|.|||  |  .. | ||.. |.. |  .|| ||| .
lvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptp
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 105-360 1.1e-83 273.9 In-house 26-299 (302) alignment 
Range on Protein: 105-360
Range on HMM: 26-299/302.0
NALLELQAPINICGDTHGQYNDLLRIFNACGA-----------ATKTQYLFLGDYVDRGGHSLEVIMLLFSLKLAMPRKMHLLRGNHELKAINKNYGFHA
..| |. .|. | || |||..||.||.||               .. ...||||||||| .|.| | |.|.||.  |..  ||||||| ||||  |||. 
ktlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillrgnhetkainfaygfre

ELKKRFQREEVYEsVYNHFNQVFSYMPLCAIVSKRILCMHGGISPHLKSLDDIRAIPLPLETAKTHPLACDLLWADPE--------KDAKGFEPNKIRAI
||..|. ... .| ....||.|||.||| |.| ..|||.||||||.|.||.||. |  ||. .   .|| |||.|||         ..   .. | .|..
elenrlgkkdgke.iwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvqllaavsekPkyaknivrgl

SNVFGKKEVDDLCKRLDIDLIVRAHQVVEYGYAFFADRRLITVFSASRYQIELCNYAAVVVVNKMLELSFVQLKP
| || .  | |.||||...|||||||..  |. ||||..|.|.|||.||. |  |. ||. |.   .||  .|..
svvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrn
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 105-360 2.4e-83 272.8 In-house 27-300 (302) alignment 
Range on Protein: 105-360
Range on HMM: 27-300/302.0
NALLELQAPINICGDTHGQYNDLLRIFNACGA-----------ATKTQYLFLGDYVDRGGHSLEVIMLLFSLKLAMPRKMHLLRGNHELKAINKNYGFHA
..| |. .|. | || |||..||.||.||               .. ...||||||||| .|.| | |.|.||.  |..  ||||||| ||||  |||. 
ktlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillrgnhetkainfaygfre

ELKKRFQREEVYEsVYNHFNQVFSYMPLCAIVSKRILCMHGGISPHLKSLDDIRAIPLPLETAKTHPLACDLLWADPE--------KDAKGFEPNKIRAI
||..|. ... .| ....||.|||.||| |.| ..|||.||||||.|.||.||. |  ||. .   .|| |||.|||         ..   .. | .|..
elenrlgkkdgke.iwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvqllaavsekPkyaknivrgl

SNVFGKKEVDDLCKRLDIDLIVRAHQVVEYGYAFFADRRLITVFSASRYQIELCNYAAVVVVNKMLELSFVQLKP
| || .  | |.||||...|||||||..  |. ||||..|.|.|||.||. |  |. ||. |.   .||  .|..
svvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrn
0049330 Metallo-dependent phosphatases 105-365 6.1e-83 271.5 In-house 50-303 (309) alignment 
Range on Protein: 105-365
Range on HMM: 50-303/309.0
NALLELQAPINICGDTHGQYNDLLRIFNACGAATKTQYLFLGDYVDRGGHSLEVIMLLFSLKLAMPRKMHLLRGNHELKAINKNYGFHAELKKRFQREev
. ||||...| ..|| |||. ||||.....|    ....||||.|||| .||||. ||..|||..|....|||||||| ..|  |||. |.. ..  |  
pnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkllypdnvfllrGNHElrllnglygfgdetlrkygae..

yesVYNHFNQVFSYMPLCAIVSKRILCMHGGISPHLKSLDDIRAIPLPLETAKThPLACDLLWADPEKDAKGFEPNKiRAISNVFGKKEVDDLCKRLDID
   ....|.......||.|.. ..|||.|||.||.|..||.||..  |||   . .| |||||.||  . .|| ||. | .. |||   |....|....|
...lweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipld.gllcdllwsdplpiregfapnp.rglgvvfghtaverflkkngld

LIVRAHQVVEYGYAFFADRRLITVFSASRYQIELCNYAAVVVVNKMLELSFVQLKPEDFEV
||.|.|..|. || .|.|..|||||||..|  .| |..||..... |..||....| ....
liirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvplll
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 107-361 8.5e-83 271.1 In-house 30-283 (284) alignment 
Range on Protein: 107-361
Range on HMM: 30-283/284.0
LLELQAPINICGDTHGQYNDLLRIFNACGAA------TKTQYLFLGDYVDRGGHSLEVIMLLFSLKLAMPRKMHLLRGNHELKAINKNYGFHAELKKRFQ
 ||..||..|.|| |||..||| ...  |         ...||||||||||| .|.|||.|||..|| .| |. ||||||| . .|..|||..| |||. 
kleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrgnhesrpvnmqygfyleckkrys

reevyESVYNHFNQVFSYMPLCAIVSKRILCMHGGISPHLKSLDDIRAIPLPLETAKTHpLACDLLWADPEKDAKGFEpNKIRAISNVFGKKEVDDLCKR
     |..|. |.  |  |||||.|||.|.||||||| .| .|... ..  |....    . .|| |||||.. .|.. .  |   .|||.| |....|.
.....ealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdig.viadltwadpeaevegyk.esprgagkvfgakavkeflkk

LDIDLIVRAHQVVEYGYAFFADRRLITVFSASRYQIELCNYAAVVVVNKMLELSFVQLKPE
 ..||.|||||||  || |||||.|.|.|||  |  .| | |||. |.. |. ||. |||.
fkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkpd
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 105-362 6.1e-81 264.7 In-house 28-278 (281) alignment 
Range on Protein: 105-362
Range on HMM: 28-278/281.0
NALLELQAPINICGDTHGQYNDLLRIFNACGAATKTQYLFLGDYVDRGGHSLEVIMLLFSLKLAMPRKMHLLRGNHELKAINKNYGFHAELKKrfqreEV
.|| |...|| . || |.|.||| |.|.  |  ......||||||||| .||||..|||.||.. . .. |||||||. ..|| |||. | .       .
kaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvnkiygfyvecvt.....ky

YESVYNHFNQVFSYMPLCAIVSKRILCMHGGISPHLKSLDDIRAIPLPLETAKtHPLACDLLWADPEKDAKGFEpNKIRAISNVFGKKEVDDLCKRLDID
 | ..  |.. |  .|. | ..||.||||||.|| | .||..| .| |..      |  |||||||.......  . .| .| .|||. ||| ||||...
GeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnld.rGlviDllwadpdnkveewk.assrGssftfGknvvddvckrleve

LIVRAHQVVEYGYAFFADRRLITVFSASRYQIELCNYAAVVVVNKMLELSFVQLKPED
||.||||||  ||  .. |.||||||.  |     | |||. |.. |..|.|.| |. 
liirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpas
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 137-361 1.1e-79 260.9 In-house 98-315 (317) alignment 
Range on Protein: 137-361
Range on HMM: 98-315/317.0
ATKTQYLFLGDYVDRGGHSLEVIMLLFSLKLAMPRKMHLLRGNHELKAINKNYGFHAELKKRFQreevyESVYNHFNQVFSYMPLCAIVSKRILCMHGGI
... .||||||||||| .|.||..|||.|||..| |..||||||| ...|..|||. | |||..     ...|. |...|  .||||.|.|.||||||||
kgykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrys.....aalyeafqlafnvlplcavvnkkilcmhGGi

SPHLKSLDDIRAIPLPLETAKTHpLACDLLWADPEKDAKGFEPNKiRAISNVFGKKEVDDLCKRLDIDLIVRAHQVVEYGYAFFADRRLITVFSASRYQI
| .| .|. . ..  ||...    . .|| ||||... ||... . |  ..|||.| |....|.||.||.|||||||| || |||||.|.|.|||  |  
seelldlkqldklkrpldipdvG.vladltwadpdaevkgykesa.rGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycG

ELCNYAAVVVVNKMLELSFVQLKPE
.| | |||. |.| |..|.  |.||
qldniaavlsvdkklkisinvlrpe
PPP_1 105-345 1.6e-78 256.6 In-house 21-262 (264) alignment 
Range on Protein: 105-345
Range on HMM: 21-262/264.0
NALLELQAPINICGDTHGQYNDLLRIFNACGAATKTQYLFLGDYVDRGGHSLEVIMLLFSLKLAMPRKMHLLRGNHELKAINKNYGFHAELKkrfqREEV
. |||....| .|||.|||..|||..|...| . .|.||||||||||| .|.|...||..|||  | ...||||||| . ..| |||. |..    ... 
enllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvtkvygFkkEvl....kkky

YESVYNHFNQVFSYMPLCAIVSKRILCMHGGISPHLKSLDDIRAIPLPLETAKTHPLACDL------LWADPEKDAKgFEPNKIRAISNVFGKKEVDDLC
 ...|. . .|| ..||.|.. ..||..|||.||.|..||.|| .    |.... .| ..|      |. |...... . .| || .. .|||. .....
skeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqee.avansiRGagylfgkdvtekfl

KRLDIDLIVRAHQVVEYGYAFFADRRLITVFSASRYQIELCNYAAVV
.. ...||.|||.|.| || |...|...|.|||| |  |  | .|.|
qknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayv
0053225 Metallo-dependent phosphatases 105-359 6.9e-76 248.5 In-house 42-289 (293) alignment 
Range on Protein: 105-359
Range on HMM: 42-289/293.0
NALLELQAPINICGDTHGQYNDLLRIFNACGAATKTQYLFLGDYVDRGGHSLEVIMLLFSLKLAMPRKMHLLRGNHELKAINKNYGFHAELKKRFQreev
. ||||...| ..|| ||.. |||.... .|    ....||||.|||| .||||. ||..|||  | ...||||||||. .|  |||..| . ..     
pnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllypdnvvllrGNHElmllnglygfgdetlrkyg....

YESVYNHFNQVFSYMPLCAIVSKRILCMHGGISPHLKSLDDIRAIPLPLETAkTHPLACDLLWADPEkDAKGFEPNKIRAIsNVFGKKEVDDLCKRLDID
 ..............||.|.. ..||..|||.||.| .||.|| |  ||.   ...| .|||| ||  . .|. |.. ...  |||   |....|. ..|
aaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplrip.legllldllwsdpd.lwsgwlpsyrglg.vvfghtavlrflkkngld

LIVRAHQVVEYGYAFFADRRLITVFSASRYQIELCNYAAVVVVNKMLELSFVQLK
||.|.||||  || .. |..|.|||||..|  .| |..||..... |  .|....
liirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfa
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 106-361 2.6e-74 243.2 In-house 27-275 (280) alignment 
Range on Protein: 106-361
Range on HMM: 27-275/280.0
ALLELQAPINICGDTHGQYNDLLRIFNACGAATKTQYLFLGDYVDRGGHSLEVIMLLFSLKLAMPRKMHLLRGNHELKAINKNYGFHAELKKRFQReevy
 | | .|||.. || | ||.|. |.|.  |   . . .||||||||| . .||..||| ||.    ...|||||||  ..|| |||. | . ..      
nlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiygfyvecqykygv....

eSVYNHFNQVFSYMPLCAIVSKRILCMHGGISPHLKSLDDIRAIPLPLETAKtHPLACDLLWADPEKDAKGFEpNKIRAISNVFGKKEVDDLCKRLDIDL
  ..  |. .|  ||.....|||.||||||.|| |  || || || | |    . |  ||||.|| . ..|.    ||.|| .|||  |.. || |.|||
.glwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepld.rgllidllwsdptnkgegwf.hsirgisymfgkgvveqacksleidl

IVRAHQVVEYGYAFFADRRLITVFSASRYQIELCNYAAVVVVNKMLELSFVQLKPE
|.||||||. || ..| ||||||||   |  .. | ||||..|  |..|| || | 
iirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlipp
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 105-360 2.1e-73 240.2 In-house 43-294 (297) alignment 
Range on Protein: 105-360
Range on HMM: 43-294/297.0
NALLELQAPINICGDTHGQYNDLLRIFNACGAATKTQYLFLGDYVDRGGHSLEVIMLLFSLKLAMPRKMHLLRGNHELKAINKNYGFHAELKKRFQREEv
....|..|||..||| |||. ||||.|   |    ..|||||||||||  |.| |.||.. |. .| .. ||||||| . .|| |||. | .||.|    
ksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecefvnkvygfyeecqkryqsvr.

yesVYNHFNQVFSYMPLCAIVSKRILCMHGGISP---HLKSLDDIRAIPLPLETAktHPLACDLLWADPEKDAKGFEPNKiRAISNVFGKKEVDDLCKRL
   .|  |..|| ..||. .....|||||||.||   .  .|| .| |  . |      | .|||||||     ||  |. |     ||.  | .||  .
...myaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierstegk..erlvadllwadpisglsgfmenq.rgagcgfgrdavlklcsef

DIDLIVRAHQVVEYGYAFFADRRLITVFSASRYQIELCNYAAVVVVNKMLELSFVQLKP
..||..||||||. || ||| |.|.|.||| .|  .. | ||.. ... |. ||  |.|
kldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilrp
subfamily_PPZ_pd Subfamily PPZ 104-362 7.1e-71 232.2 In-house 44-295 (300) alignment 
Range on Protein: 104-362
Range on HMM: 44-295/300.0
ANALLELQAPINICGDTHGQYNDLLRIFNACGAATKTQYLFLGDYVDRGGHSLEVIMLLFSLKLAMPRKMHLLRGNHELKAINKNYGFHAELKKRFQRee
  |||||  ...| || ||||.||||.|  ||   ...||||||||||| .||| |.||.  |.  | .. |||||||   . . |||. | |.| .   
qpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecanvtrvygfydeckrrcni..

vyeSVYNHFNQVFSYMPLCAIVSKRILCMHGGISPHLKSLDDIRAIPLPLETAKtHPLACDLLWADPEKDAKGFEPNKiRAISNVFGKKEVDDLCKRLDI
    ... | . |  .||.|||. .|.|.|||.|| |.|.|.|| .  | .      |  ||||.||   .. .| |. | .| .. |  .. . ... .
...kiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpd.fglindllwsdptdssnewedne.rgvsycynkvainkflnkfgf

DLIVRAHQVVEYGYAFFADRRLITVFSASRYQIELCNYAAVVVVNKMLELSFVQLKPED
||..||| ||| || || || |.|||||  |  |. |. ||. |.. |  ||  | | |
dlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldpld
subfamily_PPP4C_pd Subfamily PPP4C 107-356 2.4e-70 230.0 In-house 38-280 (288) alignment 
Range on Protein: 107-356
Range on HMM: 38-280/288.0
LLELQAPINICGDTHGQYNDLLRIFNACGAATKTQYLFLGDYVDRGGHSLEVIMLLFSLKLAMPRKMHLLRGNHELKAINKNYGFHAELKKRFQREEVye
. ....|. .||| |||..|||..|.  | . .|.||||||.|||| .|.| ..|| .||.  | ...|.||||| . | . |||. |  ...   .|  
vqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrqitqvygfydeclrkygsanv..

svYNHFNQVFSYMPLCAIVSKRILCMHGGISPHLKSLDDIRAIPLPLETAKTHPLaCDLLWADPEkDAKGFEPnKIRAISNVFGKKEVDDLCKRLDIDLI
  ...  .|| |..|.||. ..|.|.|||.||....||.||.|    |  .  || |||||.||| ||.|.     |    .||...|...... ||.||
..wryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegpl.cdllwsdpe.daegwav.sprgagylfgsdvveqfneandieli

VRAHQVVEYGYAFFADRRLITVFSASRYQIELCNYAAVVVVNKMLELSFV
.||||.|  || .  .....||.||  |     | ||.. ... |.  | 
crahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfk
subfamily_PPP3C_pd Subfamily PPP3C 105-348 4e-68 223.2 In-house 61-310 (452) alignment 
Range on Protein: 105-348
Range on HMM: 61-310/452.0
NALLELQAPINICGDTHGQYNDLLRIFNACGAATKTQYLFLGDYVDRGGHSLEVIMLLFSLKLAMPRKMHLLRGNHELKAINKNYGFHAELKKRFQrEEV
..|||..||| ..|| |||. |||..|.  |  ..|.||||||||||| .|.|... |..||.| |....||||||| . . . . |. |.|.... |||
ktlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrhlteyftfkeeckikys.eev

YESVYNhfnqVFSYMPLCAIVSKRILCMHGGISPHLKSLDDIRAIPLPLETAKTHPLaCDLLWADPEKD------AKGFEPNKIRAISNVFGKKEVDDLC
|... .     |  .|| |.. .. ||.|||.||..||||||. .    |  .. || |||||.|| .|       . | ||..|  | ... | | .. 
ydacme....sfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGpl.cdllWsdPledygeekteekfvpnsvrGcsyfysykavcefl

KRLDIDLIVRAHQVVEYGYAFFAD------RRLITVFSASRYQIELCNYAAVVVVN
.. |.  |.|||.. . ||  . .        |||.|||. |     | |||. ..
qkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkye
subfamily_PPP2C_pd Subfamily PPP2C 108-360 1.9e-67 220.5 In-house 40-285 (290) alignment 
Range on Protein: 108-360
Range on HMM: 40-285/290.0
LELQAPINICGDTHGQYNDLLRIFNACGAATKTQYLFLGDYVDRGGHSLEVIMLLFSLKLAMPRKMHLLRGNHELKAINKNYGFHAELKKRFQREevyeS
 |...|. .||| |||. ||| .|.  | . .|.||||||||||| .|.| . || .||. .. .. .|||||| . | . |||. |  ...       .
qevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhesrqitqvygfydeclrkygna....n

VYNHFNQVFSYMPLCAIVSKRILCMHGGISPHLKSLDDIRAIPLPLETAKTHPLaCDLLWADPEkDAKGFEPNKiRAISNVFGKKEVDDLCKRLDIDLIV
|...| ..| |.||.|.| ..|.|.|||.||....||.|||.    |  .  || |||||.||. | .|.   . |     |||.  ... |. .. ||.
vwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegpl.cdllwsdpd.drggwgisp.rgagytfgkdisekfnktngltlia

RAHQVVEYGYAFFADRRLITVFSASRYQIELCNYAAVVVVNKMLELSFVQLKP
||||.|  ||..  ||...|.|||  |     | ||.. ... |. ||.| .|
rahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdp
PPP_2 114-312 1.1e-66 217.4 In-house 1-197 (198) alignment 
Range on Protein: 114-312
Range on HMM: 1-197/198.0
INICGDTHGQYNDLLRIFNACGAATKTQYLFLGDYVDRGGHSLEVIMLLFSLKLAMPRKMHLLRGNHELKAINKNYGFHAELKKRFQreevYESVYNHFN
...|||.|||..|||..|. ..  ....||||||||||| .||||..||..||| .|...|||||||| | .|| |||. |..|. .     ..||....
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkg....gkkvykklq

QVFSYMPLCAIVSKRILCMHGGISPHLKSLDDIRAIPLPLETaKTHPLACDLL----WADPEKDAKGFEPNkIRAISNVFGKKEVDDLCKRLDIDLIVRA
.||...||.|......|..|||.|...|.||.|. .  . |. ... . .|||    . ||... ......  | .. .||.. ...|... ...||.||
evfelLplaalidekvlvvHGGlseeiklldqikkeerkies.peegklldlleeeklsdpkekeellans.arGagllfgpdvteelleknklkliiRa

HQV
|.|
Hev
PPP_4 114-312 1.5e-64 210.7 In-house 1-196 (197) alignment 
Range on Protein: 114-312
Range on HMM: 1-196/197.0
INICGDTHGQYNDL-LRIFNACGAAT-KTQYLFLGDYVDRGGHSLEVIMLLFSLKLAMPRKMHLLRGNHELKAINKNYGFHAELKKRfqreeVYESVYNH
. ..||.|||..|| |....  |  . ...|.||||||||| .||||..||..||| .| ...||||||| |..|. |||  |....       ..... 
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.....hgkeilkk

FNQVFSYMPLCAIVSKRILCMHGGISPHLKSLDDIRAIPLPLETAKTHPLACDL-LWADPEKDAKGFEPNkIRAISNVFGKKEVDDLCKRLDIDLIVRAH
...||...||.|......|..|||.|..|.|||.|..|  . |. ... ...|| ||.||... .|.... .| .. .||.. ....... ...||.|.|
lqdvfdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglans.vrGagllFgpdvtekfleknnlkliirsh

QV
..
el
subfamily_PPP5C_pd Subfamily PPP5C 112-356 1.3e-62 204.6 In-house 65-304 (322) alignment 
Range on Protein: 112-356
Range on HMM: 65-304/322.0
APINICGDTHGQYNDLLRIFNACGAATK-TQYLFLGDYVDRGGHSLEVIMLLFSLKLAMPRKMHLLRGNHELKAINKNYGFHAELKKRFQreevyESVYN
  . .|||.|||. ||| ||.  | ...   ||| ||.|||| .|.|||..|...||  | ...| ||||| . .|| |||. | |....     | |..
kkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnklyGfegevkakyt.....ekvad

HFNQVFSYMPLCAIVSKRILCMHGGIS-PHLKSLDDIRAIPLPLETAKTHpLACDLLWADPEKdAKGFEPNKiRAISNVFGKKEVDDLCKRLDIDLIVRA
 |..||...||. .. ...| .|||.   .  .|||.| |    .  .   | ..|||.||.. |.|  | | | ..  ||    . ..|  ...||.|.
lftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeeg.llvellwsdpqe.anGrspsk.rGvgvqfGpdvtkkflkennleliirs

HQVVEYGYAFFADRRLITVFSASRYQIELCNYAAVVVV-NKMLELSFV
|.| | || .  | .|||||||  |  .  | .|.. . .. |.| | 
hevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfk
subfamily_PPP6C_pd Subfamily PPP6C 108-352 1.4e-62 204.5 In-house 38-275 (290) alignment 
Range on Protein: 108-352
Range on HMM: 38-275/290.0
LELQAPINICGDTHGQYNDLLRIFNACGAATKTQYLFLGDYVDRGGHSLEVIMLLFSLKLAMPRKMHLLRGNHELKAINKNYGFHAELKKRFQREEvyes
  ...|. .||| |||. ||. .|.. |   .|.|.||||.|||| .||| . .|..||.  | .. ||||||| . | . |||. | .... . .    
qpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesrqitqvygfydeclnkygnan....

VYNHFNQVFSYMPLCAIVSKRILCMHGGISPHLKSLDDIRAIPLPLETAKTHPLaCDLLWADPEkDAKGFEPNKiRAISNVFGKKEVDDLCKRLDIDLIV
..... .||  ....||. ...||.|||.||..| ||.|| |    | ..  .. |||.|.||| | . ..  . |    .||.| ......  ...||.
awkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgaf.cdlvwsdpe.dvetwavsp.rgagylfgskvtkefvhinnlklic

RAHQVVEYGYAFFADRRLITVFSASRYQIELCNYAAVVVVNKMLE
||||.|| |. .. | .|.||.||  |     | |... ...  |
rahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaee
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 139-362 1.4e-62 204.7 In-house 119-335 (339) alignment 
Range on Protein: 139-362
Range on HMM: 119-335/339.0
KTQYLFLGDYVDRGGHSLEVIMLLFSLKLAMPRKMHLLRGNHELKAINKNYGFHAELKKRFQReEVYESvynhFNQVFSYMPLCAIVSKRILCMHGGISP
  .|||||||||||  |.||..|| .|||| | ...||||||| ...|  |||. |.. |..  ..||     |...|  .|.||.. . |.||||||| 
ykrylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyryda.qlyec....fqnmfnvfpfcavinntimcmhggise

HLKSLDDIRAIPLPLETAKTHPLaCDLLWADPEKDAKGFEPNkIRAISNVFGKKEVDDLCKRLDIDLIVRAHQVVEYGYAFFADRRLITVFSASRYQIEL
|| |....  .  |||      |  || ||||.   ||..|   |  | |||   .  . |.||.....| ||||| || ||  |||.|.|||  |  . 
hltsfnqfsvfkrpleipdvgvl.tdltwadpdptekgykps.argasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqn

CNYAAVVVVNKMLELSFVQLKPED
 | |||. ..| |..|   ..|| 
dntaavfsidkklkisinvfrpes
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 104-366 5e-62 202.8 In-house 39-297 (307) alignment 
Range on Protein: 104-366
Range on HMM: 39-297/307.0
ANALLELQAPINICGDTHGQYNDLLRIFNACGAATKTQYLFLGDYVDRGGHSLEVIMLLFSLKLAMPRKMHLLRGNHELKAINKNYGFHAELKKRFQRee
 .||.... |  . || |||.|||. .|   |   .| |.| |||||||  |||.|.|||. |...| .. |||||||.  .||.|||. |      .  
ekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygfyeecvtsipk..

VYESVYNHFNQVFSYMPLCAIVSKRILCMHGGISPHLKSLDDIRAIPLPLETAkTHPLACDLLWADPEKDAKGFEpNKIRAISNVFGKKEVDDLCKRLDI
. | ..  |...|  .|. |... .|||||||.|| |  ||..|  | |.       .  |.|||||.     .     |     || . .||.|||| .
cgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnp.frgivndmlwadpdpsvfewk.assrgsgftfgtnviddvckrlgv

DLIVRAHQVVEYGYAFFADRRLITVFSASRYQIELCNYAAVVVVNKMLELSFVQLKPEDFEVR
.||.||||..  ||  .. |.|||.|||  |     |  .|. |.. | .  | . ||  .. 
eliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpesenie
PPP_5_Dcr2 114-313 1.8e-61 200.6 In-house 1-199 (199) alignment 
Range on Protein: 114-313
Range on HMM: 1-199/199.0
INICGDTHGQYNDL-LRIFNACGAAT-KTQYLFLGDYVDRGGHSLEVIMLLFSLKLAMPRKMHLLRGNHELKAINKNYGFHAELKKRFqreeVYESVYNH
. .|||.|||..|| |..|. .|  . ...|.||||||||| .||||..||..||| .|...|||||||| ...|. |||  | ....      ...|. 
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlsky....hgkkiyki

FNQVFSYMPLCAIVSKRILCMHGGISPHLKSLDDIRAIPLPLETAKTHPLACDL-LWADPEKDAKGFEPNKIRAISNVFGKKEVDDLCKRLDIDLIVRAH
...||...||.|......|..|||.||..||......|  . |. ...   .|| ||.||... .|   |..| .. .||.. ....... ...||.|.|
lsdvfdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirsh

QVV
...
elk
subfamily_PPG1_pd Subfamily PPG1 107-355 7.9e-61 198.9 In-house 36-290 (300) alignment 
Range on Protein: 107-355
Range on HMM: 36-290/300.0
LLELQAPINICGDTHGQYNDLLRIFNACGAATKTQYLFLGDYVDRGGHSLEVIMLLFSLKLAMPRKMHLLRGNHELKAINKNYGFHAELKKRFQREevyE
. |...|. . || |||. |.| ||.  | .  |.||||||||||| .|.| |.||  |||  | ...||||||| . | . |||..|  ...  .    
vieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrqitqvygfyteclrkyggn...s

SVYNHFNQVFSYMPLCAIVSKRILCMHGGISPHLKSLDDIRAIPLPLETAKTHPLAcDLLWADPE---------KDAKG--FEpNKIRAISNVFGKKEVD
 |.... ..| |. |.||. . | |.|||.||  .|.|.|. .    |  .   || ||||.|||          | .|  |  .  |     .||. | 
rvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegala.dllwsdpeennnptldhpdregqhfv.vsqrgagysygkdvve

DLCKRLDIDLIVRAHQVVEYGYAFFADRRLITVFSASRYQIELCNYAAVVVVNKMLELSF
 . .  |.. |.||||..  ||  . | .| ||.||  |     | |... ... .|  |
kflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyf
subfamily_PPPLV_pd Subfamily PPPLV 104-350 2.3e-58 190.8 In-house 16-278 (290) alignment 
Range on Protein: 104-350
Range on HMM: 16-278/290.0
ANALLELQAPINICGDTHGQYNDLLR----IFNACGAATKTQYLFLGDYVDRGGHSLEVIMLLFSLKLAMPRKMHLLRGNHELKAINKNYGFHAELKKRF
 . ||||..|. . || ||.|.||      ..      | ...|||||||||| .|.|.|  |..||. .| |..||||||||... ... ...| . .|
eerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqesieykgegsfkf

qrEEVYESVYNHFNQVFSYMPLCAIVSKRILCMHGGISPHLKSLDDIRA---IPLPL-ETAKTHPLACDLLWADPEKD-----------AKGFEPNKIRA
   .  |.|.. ||.|| ..|| |.. ....|.|.||    ..   | |   |.  | . ..  ||| |.||.||..|            .|| .|. | 
..gdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvlneGfvdndrrG

ISNVFGKKEVDDLCKRLDIDLIVRAHQVVEYGYAFFADRRLITVFSASRYqIELCNYAAVVVVNKM
 . ||... .. . || ... ..|||.| | |. .  . ||.||||.|||   . | ||...|.| 
tghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssry.cGssneaalilvdkk
Metallophos Calcineurin-like phosphoesterase 113-312 4.3e-42 137.6 Pfam-A 2-198 (200) alignment 
Range on Protein: 113-312
Range on HMM: 2-198/200.0
PINICGDTHGQYNDL----LRIFNACGAATKTQYLFLGDYVDRGGHSLEVIMLL--FSLKLAMPRKMHLLRGNHELKAINKNYGFHAELKKRF-------
.| ..||.||...||    |.......    . .|||||.|||| .|.|...||  ..|||..| . .||||||| . .|. |||. |  |.        
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

----------------------QREEVYESVYNHFNQVFSYMPLCAIVSKRILCMHGGISPHLKSLDDIraiplpletakthplacdllwadpekdakgf
                       . ..  |.. .....| ..||.|.| ..||..||..|....| |||                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

epnkiraISNVFGKKEVDDLCKRLDIDLIVRAHQV
        |  ||......|... ..||..|.|. 
.......gselfgpdalekllekygvdlvlrGHtH
subfamily_PPP7C_pd Subfamily PPP7C 113-239 1.5e-37 122.3 In-house 65-190 (383) alignment 
Range on Protein: 113-239
Range on HMM: 65-190/383.0
PINICGDTHGQYNDLLRIFNACGAA-TKTQYLFLGDYVDRGGHSLEVIMLLFSLKLAMPRKMHLLRGNHELKAINKNYGFHAELKKRFQREEvyESVYNH
 . .||| ||. .||| |.   |   ..  |.| ||.|||| .|.|....|..| |..|....| ||||| . .|  |||  |.........  . . . 
evtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhg..kkilrl

FNQVFSYMPLCAIVSKRILCMHGGISPH
...||...||.... ..|| .||||| .
ledvfawlplatlidekilivhGGisdk
subfamily_PPP7C_pd Subfamily PPP7C 263-359 6.4e-17 54.3 In-house 238-333 (383) alignment 
Range on Protein: 263-359
Range on HMM: 238-333/383.0
CDLLWADPEKdAKGFEPNKIRAISNVFGKKEVDDLCKRLDIDLIVRAHQVVEYGYAFFADRRLITVFSASRYQIELCNYAAVVVVNKMLELSFVQLK
 |.||.||..  .|  || .|     ||    ..| .. ...|..|.|.    || |  |....|.|||| |  |  |  | | ..| |.  .|| .
ldilwsdpka.keGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqyq
subfamily_YNL217W_pd Subfamily YNL217W 114-238 3.3e-08 26.3 In-house 12-138 (235) alignment 
Range on Protein: 114-238
Range on HMM: 12-138/235.0
INICGDTHGQYNDLLRIFN--ACGAATKTQYLFLGDYVDRGGHSLEVIMLLfslklaMPRKMHLLRGNHELKAI------NKNYGFHAE-LKKRFQRE--
. . || || |..|.....  . |       ...|| ...| .|.||. ..         . . ..||||  ..       |. |..     ..|.    
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllaykwvkkpkgaeplefsskfsfles

EVYESVYNH-FNQVFSymplCAIVSKRILCMHGGISP
.. .. ... ..  ||      | |. .| .|.|..|
klskadmeyarelgfs....ldipsdellvvhaGlvp
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 107-135 2.8e-07 23.0 In-house 31-59 (317) alignment 
Range on Protein: 107-135
Range on HMM: 31-59/317.0
LLELQAPINICGDTHGQYNDLLRIFNACG
 |||.||. |.|| |||..||| ...  |
kleleapvtivGdihGqfedllalldlnG