Gene C27B7.6 in Caenorhabditis elegans

Synonym: CELE_C27B7.6, C27B7.6

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily CelePPP-sf3
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP028_AA protein Get Run
CeleP028_AA_21-307 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 17-304 9e-170 556.1 In-house 2-290 (290) alignment 
Range on Protein: 17-304
Range on HMM: 2-290/290.0
QMIARIEKYGTLEGFSDSDILEVLKTIKEILEPLPCLIEIIAPVVVFGDIHGQLGDLLQFTNEVGRPPDFQYLFLGDYVDRGPNSLEVTVWLFCMKILFS
.|| ...|||.|..|||.||||.|..|.|||||||.|.|..||.|..|||||||..||.....||.||....||||||||||..||||...|||.||..|
rmiehllkygvldafsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykirys

KKVHLLRGNHEVRRVNTMYGFKEEMMRKRNSHLWKVFNDVFAELSICASINRKILCMHGGISPKIESWDSLTGMTKPRVHGDCEHGLIVDLIWSDPNR-K
|||||||||||||.||..||||||..|||.|.|||...|||||||.||...|||||||||||.|||||.||....||||...|..||.|||.|.||.| |
kkvhllrgnhevrkvnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdk

DDTIQFNKMRGISTLFGKSVVDNLCTTLAIDLIIRAHEMKEKGHTFEFDNRLLTVFSAPYYSGHNSNLGSVATISKSLKLRIVTLKPNK
||||..||.|.||..|||...|.|...||..||.||||.||.|..|.||..|.||||||||||...|||..||.|.||.|.||.|||.|
ddtialnkqraisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkprk
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 22-308 3e-158 518.2 In-house 1-287 (287) alignment 
Range on Protein: 22-308
Range on HMM: 1-287/287.0
IEKYGTLEGFSDSDILEVLKTIKEILEPLPCLIEIIAPVVVFGDIHGQLGDLLQFTNEVGRPPDFQYLFLGDYVDRGPNSLEVTVWLFCMKILFSKKVHL
..|||.|..|||.||||||..|.|||||||.|.|..||....|||||||.|||...|.||..|..||||||||||||..||||...||..||...|||||
llkygvldafsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhl

LRGNHEVRRVNTMYGFKEEMMRKRNSHLWKVFNDVFAELSICASINRKILCMHGGISPKIESWDSLTGMTKPRVHGDCEHGLIVDLIWSDPNRKDDTIQF
|||||||...|..||||||..|||...|.|.|||||.||..||.....|||||||||||..|.|||....||.....|..||.|||.|.||.....|...
lrGnhevkkinklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfel

NKMRGISTLFGKSVVDNLCTTLAIDLIIRAHEMKEKGHTFEFDNRLLTVFSAPYYSGHNSNLGSVATISKSLKLRIVTLKPNKGYDR
||.|.||..|||..||.|...|.||||.||||..|.|..|.||.||.||||||||||...|||.|...||||.|..|.|||.....|
nkiraisvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkpedfevr
PP2Ac_SM00156 32-304 1.4e-108 355.1 In-house 2-271 (271) alignment 
Range on Protein: 32-304
Range on HMM: 2-271/271.0
SDSDILEVLKTIKEILEPLPCLIEIIAPVVVFGDIHGQLGDLLQFTNEVGRPPDFQYLFLGDYVDRGPNSLEVTVWLFCMKILFSKKVHLLRGNHEVRRV
|....||.|...||||.  ..|.|. |||.|.||||||| |||..... |.||. .|.||||||||||.|.|| ..||..|||...||.||||||| ..|
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

NTMYGFKEEMMRKRNSHLWKVFNDVFAELSICASINRKILCMHGGISPKIESWDSLTGMTKprVHGDCEHGLIVDLIWSDPNRKDDTIQFNKmRGISTLF
|..|||.||..|| .......|...|. |...| ...||||||||.||..||.|... ...  |. ..|.||..||.||||..|....|..| ||.|..|
nkiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkr..vkekpeegllidllwsdpeqkekgfqpsk.rglsvvF

GKSVVDNLCTTLAIDLIIRAHEMKEKGHTFEFDNRLLTVFSAPYYSGHNSNLGSVATISKSLKLRIVTLKPNK
|...|..........|||||||....|..|..|..|.|.||||.| ...||...|....|.|||.|..||..|
gedavkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeqk
PPP_3 33-300 2.6e-96 314.8 In-house 4-269 (271) alignment 
Range on Protein: 33-300
Range on HMM: 4-269/271.0
DSDILEVLKTIKEILEPLPCLIEIIAPVVVFGDIHGQLGDLLQFTNEVGRPPDFQYLFLGDYVDRGPNSLEVTVWLFCMKILFSKKVHLLRGNHEVRRVN
 ... |..|..|||||  ..|.|| |||.|.||||||| |||......|..|. .||||||||||| .|||| ..|...||...|.||||||||| |..|
enelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrqin

TMYGFKEEMM-RKRNSHLWKVFNDVFAELSICASINRKILCMHGGISPKIESWDSLTGMTKPRVHgdCEHGLIVDLIWSDPNRKDDTIQFNkMRGISTLF
..||||.|.. .| .....|....||. |...| |..|.|..|||.||.|.|.|... .......  .|.|...|| .|....|..... .  ||...||
kvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkiev..peegklldlllssdpekeeglens.krGagllF

GKSVVDNLCTTLAIDLIIRAHEMKEKGHTFEFDNRLLTVFSAPYYSGHNSNLGSVATISKSLKLRIVTL
|..|.......  ..|||||||.||.|.....|....|||||| | ...||.|........|. ....|
gpdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkql
subfamily_PPP1C_pd Subfamily PPP1C 32-304 8.6e-89 290.4 In-house 11-280 (282) alignment 
Range on Protein: 32-304
Range on HMM: 11-280/282.0
SDSDILEVLKTIKEILEPLPCLIEIIAPVVVFGDIHGQLGDLLQFTNEVGRPPDFQYLFLGDYVDRGPNSLEVTVWLFCMKILFSKKVHLLRGNHEVRRV
. ..| ..||. .|||   | |.|. ||| ..||||||. |||.. .  | ||. .||||||||||| .|||. | |...|| ......|||||||   .
keaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesasi

NTMYGFKEEMMRKRNSHLWKVFNDVFAELSICASINRKILCMHGGISPKIESWDSLTGMTKPRVHGdcEHGLIVDLIWSDPNRKDDTIQFNKmRGISTLF
|..|||..|. |. ...|||.|.|||. | ..| .. ||||.|||.||...| . .. ...|      |.||..||.||||...  ... |. ||.|  |
nriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevp..ekgllcdllWsdpdkevlgwsend.rGvsftf

GKSVVDNLCTTLAIDLIIRAHEMKEKGHTFEFDNRLLTVFSAPYYSGHNSNLGSVATISKSLKLRIVTLKPNK
||.||.....   .|||.|||.. |.|. |  ...|.|||||| | |.  | |.| .....|...   |||.|
gkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpak
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 24-304 9.6e-86 280.5 In-house 17-295 (298) alignment 
Range on Protein: 24-304
Range on HMM: 17-295/298.0
KYGTLEGFSDSDILEVLKTIKEILEPLPCLIEIIAPVVVFGDIHGQLGDLLQFTNEVGRPPDFQYLFLGDYVDRGPNSLEVTVWLFCMKILFSKKVHLLR
.    .  ...|. ..... |.|..  . |.|. ||. | ||||||  |||.. .. | |||  ||||||||||| ..||| | |.. |. . ... |||
ekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnffllr

GNHEVRRVNTMYGFKEEMMRKR-NSHLWKVFNDVFAELSICASINRKILCMHGGISPKIESWDSLTGMTKPRvhGDCEHGLIVDLIWSDPNRKDDTIQFN
||||.  .| .|||.||. |.  . .|.. |.|||. | ..| |  .|||||||.|.|..|.|.|  ...|    . |. | .||.|.||...    . |
GnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpf..dskeeslaidllwadpenavkgwaen

kMRGISTLFGKSVVDNLCTTLAIDLIIRAHEMKEKGHTFEFDNRLLTVFSAPYYSGHNSNLGSVATISKSLKLRIVTLKPNK
  ||.|. ||. || .|. .| |||..||| .   |. |  ...|.|.||||.| |.  |  .| .... |..  . |||.|
.srGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpek
0045823 Metallo-dependent phosphatases 23-307 1.9e-85 280.3 In-house 35-328 (473) alignment 
Range on Protein: 23-307
Range on HMM: 35-328/473.0
EKYGTLEGFSDSDILEVLKTIKEILEPLPCLIEIIAPVVVFGDIHGQLGDLLQFTNEVGRPPDFQYLFLGDYVDRGPNSLEVTVWLFCMKILFSKKVHLL
| . ... .. .|.|..|. .||||   | |.|. ...||.||||||| |||.  . .|.||. ...||||.|||||.||||  .|...||.. ..|.||
ehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkikypgnvfll

RGNHEVRRVNTMYGFKEEMMRKRNSHLWKVFNDVFAELSICASINRKILCMHGGISPKIESWDSLTGMTKPRVHGDceHGLIVDLIWSDPnRKDDTI---
||||| | .|..|||..|...| . .|.. |..... | ..| |. |||..|||.|| ....| .  . .|. . |  .||..|| ||||   ||     
rGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipd..dgllldllwsdP.weddgdgll

----QFNKMRGISTLFGKSVVDNLCTTLAIDLIIRAHEMKEKGHTFEFDNR------LLTVFSAPYYSGHNSNLGSVATISKSLkLRIVTLKPNKGYD
      |  ||.. |||. .|....    .|||.|.|.. . |. . ||..      ..|||||| | |.. ||..|..|.. | . .....| .   
rlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsphpl
0049330 Metallo-dependent phosphatases 22-304 2.5e-81 266.2 In-house 21-300 (309) alignment 
Range on Protein: 22-304
Range on HMM: 21-300/309.0
IEKYGTLEGFSDSDILEVLKTIKEILEPLPCLIEIIAPVVVFGDIHGQLGDLLQFTNEVGRPPDFQYLFLGDYVDRGPNSLEVTVWLFCMKILFSKKVHL
||.. .|  .| ...|..|  .||||   | |.|. ...||.||||||| |||.  . .| ||. ...||||.|||||.||||  .|...|.|. ..|.|
ielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkllypdnvfl

LRGNHEVRRVNTMYGFKEEMMRKRNSHLWKVFNDVFAELSICASINRKILCMHGGISPKIESWDSLTGMTKPRVHGDCehGLIVDLIWSDPNRKDDTIQF
|||||| | .| .|||..|..|| ...||. |.|... | ..| |. ||||.|||.|| . ..|..  . .|.   .   ||..||.||||..  .... 
lrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipld..gllcdllwsdplpiregfap

NKmRGISTLFGKSVVDNLCTTLAIDLIIRAHEMKEKGHTFEFDNRLLTVFSAPYYSGHNSNLGSVATISKSLKLRIVTLKPNK
|. ||.. .||  .|....... .|||||.|.. . |. . ||..|.|||||| | |...|||.| .|...|........| .
np.rglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvp
PPP_1 34-287 8.3e-77 251.0 In-house 4-262 (264) alignment 
Range on Protein: 34-287
Range on HMM: 4-262/264.0
SDILEVLKTIKEILEPLPCLIEIIAPVVVFGDIHGQLGDLLQFTNEVGRPPDFQYLFLGDYVDRGPNSLEVTVWLFCMKILFSKKVHLLRGNHEVRRVNT
. . |..|. ||.|.  . |.|. ... | ||||||. |||.. .  | .|. .||||||||||| .|.|. . |...|. . |...||||||| |.|..
eelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvtk

MYGFKEEMM-RKRNSHLWKVFNDVFAELSICASINRKILCMHGGISPKIESWDSLTGMTKPRVHgdCEHGLIVDL-------IWSDPNRKDDTIQfNKMR
.||||.|.. .| .....|.. |||. |...| |. |||..|||.||.... |.   ... ..    |.| . ||        .||......... | .|
vygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktev..peegklcdllekdvdillsddkeqeeava.nsiR

GISTLFGKSVVDNLCTTLAIDLIIRAHEMKEKGHTFEFDNRLLTVFSAPYYSGHNSNLGSVA
|.. ||||.|..... .  ..|||||||.||.|. | ......|.|||. |  . ||.|.. 
GagylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayv
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 32-303 1.2e-76 250.5 In-house 7-275 (280) alignment 
Range on Protein: 32-303
Range on HMM: 7-275/280.0
SDSDILEVLKTIKEILEPLPCLIEIIAPVVVFGDIHGQLGDLLQFTNEVGRPPDFQYLFLGDYVDRGPNSLEVTVWLFCMKILFSKKVHLLRGNHEVRRV
 . || .|... |.||    ...|. ||| | ||.|||  |||.. ..|. ||| .|||||||||||   ||| . |.. |. . ..  .||||||| ..
keadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisi

NTMYGFKEEMMRKRNSHLWKVFNDVFAELSICASINRKILCMHGGISPKIESWDSLTGMTKPRvHgDCEHGLIVDLIWSDPNRKDDTIQfNKMRGISTLF
|  ||||.|..|. . .|.. |.... .| ..| .. .|||||||.|.|. |.| |. ...|  .   .. |  ||.|.||. |      .. ||.|..|
nrkygfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpf.d.sedeclamdllwadpenkvtgwa.ensrgvsvif

GKSVVDNLCTTLAIDLIIRAHEMKEKGHTFEFDNRLLTVFSAPYYSGHNSNLGSVATISKSLKLRIVTLKPN
|. || .|.  | ||||.| |.. . |. |  |..|.|||||| | |. .|  .|  ... |.. .  |||.
ganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpa
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 33-303 3.4e-75 245.9 In-house 10-277 (281) alignment 
Range on Protein: 33-303
Range on HMM: 10-277/281.0
DSDILEVLKTIKEILEPLPCLIEIIAPVVVFGDIHGQLGDLLQFTNEVGRPPDFQYLFLGDYVDRGPNSLEVTVWLFCMKILFSKKVHLLRGNHEVRRVN
. .| .|.. .. |.     |.|| .|.|| ||.|.|  || .  . .||.|. ...||||||||||.|||| . ||..|| . ... |||||||. .||
keeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvn

TMYGFKEEMMRKRNSHLWKVFNDVFAELSICASINRKILCMHGGISPKIESWDSLTGMTKPrvHGDCEHGLIVDLIWSDPNRKDDTiQFNKMRGISTLFG
 .||| .| . |    ||  |.  | .| | | |....||||||.||.. . | |  . ||    . . ||..||.|.||. |     .. .||.| .||
kiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkp..irnldrGlviDllwadpdnkvee.wkassrGssftfG

KSVVDNLCTTLAIDLIIRAHEMKEKGHTFEFDNRLLTVFSAPYYSGHNSNLGSVATISKSLKLRIVTLKPN
|.|||. | .| ..|||||| .   | .     .|.||||.| |  .  | ..| .. ..|....|.| |.
knvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpa
0053225 Metallo-dependent phosphatases 22-302 4.4e-74 242.5 In-house 13-290 (293) alignment 
Range on Protein: 22-302
Range on HMM: 13-290/293.0
IEKYGTLEGFSDSDILEVLKTIKEILEPLPCLIEIIAPVVVFGDIHGQLGDLLQFTNEVGRPPDFQYLFLGDYVDRGPNSLEVTVWLFCMKILFSKKVHL
|| . .|  .| ...|..| ..||||   | |.|. ....|.|||||.| |||.  . .| ||. ...||||.|||||.||||  .|...|.|. ..|.|
ielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllypdnvvl

LRGNHEVRRVNTMYGFKEEMMRKR-NSHLWKVFNDVFAELSICASINRKILCMHGGISPKIESWDSLTGMTKPRVHGdcEHGLIVDLIWSDPNRKDDtiQ
|||||| . .| .|||..|..||  ...||. ..|... | ..| |. |||..|||.|| . ..|..  . .|      ..||. || ||||.. ..   
lrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplrip..legllldllwsdpdlwsg..w

FNKMRGISTLFGKSVVDNLCTTLAIDLIIRAHEMKEKGHTFEFDNRLLTVFSAPYYSGHNSNLGSVATISKSLKLRIVTLKP
  ..||.. .||  .|......  .|||||.|..   |... ||..|.|||||| | |...|||.| .....|. ......|
lpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfap
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 33-303 1.1e-71 234.6 In-house 26-294 (299) alignment 
Range on Protein: 33-303
Range on HMM: 26-294/299.0
DSDILEVLKTIKEILEPLPCLIEIIAPVVVFGDIHGQLGDLLQFTNEVGRPPDFQYLFLGDYVDRGPNSLEVTVWLFCMKILFSKKVHLLRGNHEVRRVN
. .. .. .  |...   ..|.|. ||..| ||||||  |||.. .  | ||| ..|||||||||| . ||. . |.|.|| . .. ..||||||.  .|
eqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecpain

TMYGFKEEMMRKRN-SHLWKVFNDVFAELSICASINRKILCMHGGISPKIESWDSLTGMTKPRVHgdCEHGLIVDLIWSDPNRKDDTIQFNkMRGISTLF
 .||| ||  .. . . || .|.| || . ..  |. .|||||||.|||... | |  .|.|.     .  | .||.|.||..     . | .||.| .|
rvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdp..pnpslgidllwadpdqsvkdwlan.vrgvsyvf

GKSVVDNLCTTLAIDLIIRAHEMKEKGHTFEFDNRLLTVFSAPYYSGHNSNLGSVATISKSLKLRIVTLKPN
|. || . . .| |||. |||.. . |. |  ...|.|.||||.| |   |  ..  . . |   .| ||| 
gqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkpt
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 53-303 1.9e-71 233.8 In-house 2-256 (263) alignment 
Range on Protein: 53-303
Range on HMM: 2-256/263.0
LIEIIAPVVVFGDIHGQLGDLLQFTNEVGRPPDFQYLFLGDYVDRGPNSLEVTVWLFCMKILFSKKVHLLRGNHEVRRVNTMYGFKEEMMRKRN-----S
|.|. ||. . || |||  |||.  | .|     ||||||||||||  |||| . || .|. . .|.||||||||.. .|  |||. |. .. .      
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

HLWKVFNDVFAELSICASINRKILCMHGGISPKIESWDSLTGMTKPrVHGDCEHGLIVDLIWSDPNRKDDTIQFNKMRGISTLFGKSVVDNLCTTLAIDL
 ... ||.||. . .|| ....||||||||||...| | .  .  | .     | | .||.|.||..    .. ||.| || .|||  ||.||  | |||
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplp.letakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidl

IIRAHEMKEKGHTFEFDNRLLTVFSAPYYSGHNSNLGSVATISKSLKLRIVTLKPN
|.|||.. | |..|  | ||.|||||  |     |  .|  . | |.| .| |||.
ivrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkpe
PPP_2 60-255 3.3e-68 222.3 In-house 1-198 (198) alignment 
Range on Protein: 60-255
Range on HMM: 1-198/198.0
VVVFGDIHGQLGDLLQFTNEVGRPPDFQYLFLGDYVDRGPNSLEVTVWLFCMKILFSKKVHLLRGNHEVRRVNTMYGFKEEMM-RKRNSHLWKVFNDVFA
|.|.||.|||| |||..... ...|. .||||||||||| .|||| ..|...|. . |.||||||||| ..||..||||.|.. .| .....| ...||.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

ELSICASINRKILCMHGGISPKIESWDSLTGMTKPRVHgdCEHGLIVDLI----WSDPNRKDDTIQfNKMRGISTLFGKSVVDNLCTTLAIDLIIRAHEM
 |...| |..|.|..|||.|..|...|. . .......  .|.|...||     .|||..|..... |. ||...|||..|...|...  ..|||||||.
lLplaalidekvlvvHGGlseeiklldqikkeerkies..peegklldlleeeklsdpkekeella.nsarGagllfgpdvteelleknklkliiRaHev

K
|
k
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 31-302 3.5e-68 223.1 In-house 8-282 (284) alignment 
Range on Protein: 31-302
Range on HMM: 8-282/284.0
FSDSDILEVLKTIKEILEPLPCLIEIIAPVVVFGDIHGQLGDLLQFTNEVGRP------PDFQYLFLGDYVDRGPNSLEVTVWLFCMKILFSKKVHLLRG
... ...|.    .|..   .  .|| ||| . ||||||  |||.. .  | |       . .|||||||||||| |.|| . ||..|.|. .|| ||||
lkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrg

NHEVRRVNTMYGFKEEMMRKRNSHLWKVFNDVFAELSICASINRKILCMHGGISPKIESWDSLTGMTKPRVHGDCehGLIVDLIWSDPNRKDDTIQfNKM
||| | ||  ||| .|  ..    |...|.  |  . .|| ...||.||||||| .. . . |  . .|    |   |.| || |.||. . .. . .  
nhesrpvnmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdi..gviadltwadpeaevegyk.esp

RGISTLFGKSVVDNLCTTLAIDLIIRAHEMKEKGHTFEFDNRLLTVFSAPYYSGHNSNLGSVATISKSLKLRIVTLKP
||   .||.. |.... .  .||..|||..   |. |  |..|.|.||||.| |.  |...| .... |   ...|||
rgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkp
subfamily_PPZ_pd Subfamily PPZ 32-301 3e-67 220.2 In-house 26-292 (300) alignment 
Range on Protein: 32-301
Range on HMM: 26-292/300.0
SDSDILEVLKTIKEILEPLPCLIEIIAPVVVFGDIHGQLGDLLQFTNEVGRPPDFQYLFLGDYVDRGPNSLEVTVWLFCMKILFSKKVHLLRGNHEVRRV
 .|.||.. .  .|..   |.|.|.  .| . ||.||| .|||..  ..| ||  .||||||||||| .|||  . |.| || . ... |||||||.  |
knseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecanv

NTMYGFKEEMMRKRNSHLWKVFNDVFAELSICASINRKILCMHGGISPKIESWDSLTGMTKPRVHGDceHGLIVDLIWSDPNRKDDTIQFNKmRGISTLF
  .||| .|  |. | ..|| | | |  | ..| .  ||.|.|||.|| ..| | .  ...|    |   ||| ||.||||    .  . |. ||.|  .
trvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpd..fglindllwsdptdssnewedne.rgvsycy

GKSVVDNLCTTLAIDLIIRAHEMKEKGHTFEFDNRLLTVFSAPYYSGHNSNLGSVATISKSLKLRIVTLK
 |  ....   . .||. ||| . | |. |  |  |.|||||| | |   | |.| ..|. |   .  | 
nkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelld
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 87-303 2.6e-66 217.0 In-house 102-315 (317) alignment 
Range on Protein: 87-303
Range on HMM: 102-315/317.0
QYLFLGDYVDRGPNSLEVTVWLFCMKILFSKKVHLLRGNHEVRRVNTMYGFKEEMMRKRNSHLWKVFNDVFAELSICASINRKILCMHGGISPKIESWDS
.|||||||||||| |.|| . ||..|.|. .||.||||||| | ||| ||| .|. .. ...|...|. .|  | .|| .| |||||||||| .. . . 
kylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldlkq

LTGMTKPRVHGDCehGLIVDLIWSDPNRKDDTIQfNKMRGISTLFGKSVVDNLCTTLAIDLIIRAHEMKEKGHTFEFDNRLLTVFSAPYYSGHNSNLGSV
|  . .|    |   |.. || |.||. . .. . .  || ...||.. |.... .| .||..|||.. | |. |  | .|.|.|||| | |.. |...|
ldklkrpldipdv..Gvladltwadpdaevkgyk.esarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaav

ATISKSLKLRIVTLKPN
 .. | ||. | .|.|.
lsvdkklkisinvlrpe
PPP_4 60-255 3.4e-66 216.0 In-house 1-197 (197) alignment 
Range on Protein: 60-255
Range on HMM: 1-197/197.0
VVVFGDIHGQLGDL-LQFTNEVGRPP-DFQYLFLGDYVDRGPNSLEVTVWLFCMKILFSKKVHLLRGNHEVRRVNTMYGFKEEMMRKRNSHLWKVFNDVF
|.|.||||||| || |....  |.|. . .|.|||||||||..|||| ..|...|. . |.|.||||||| . .| .||||.|...|......| ..|||
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvf

AELSICASINRKILCMHGGISPKIESWDSLTGMTKPRVHgDCEHGLIVDL-IWSDPNRKDDTiQFNKMRGISTLFGKSVVDNLCTTLAIDLIIRAHEMK
. |...| |..|.|..|||.|...||.|..  ......  ..|.... || .||||......   |. ||...|||..|.......  ..||||.||.|
dllplaalidekvlvvhgglsdelesldkierierkies.pleeekrkdlllwsdpreaqeg.lansvrGagllFgpdvtekfleknnlkliirshelk
subfamily_PPP2C_pd Subfamily PPP2C 20-302 4e-66 216.1 In-house 6-285 (290) alignment 
Range on Protein: 20-302
Range on HMM: 6-285/290.0
ARIEKYGTLEGFSDSDILEVLKTIKEILEPLPCLIEIIAPVVVFGDIHGQLGDLLQFTNEVGRPPDFQYLFLGDYVDRGPNSLEVTVWLFCMKILFSKKV
. |||    . ...|.. |. . .||||.    . |. .|| | ||.|||. |||.. .  |. || .|||||||||||  |.|   .| ..|. . ...
klieklkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeri

HLLRGNHEVRRVNTMYGFKEEMMRKR-NSHLWKVFNDVFAELSICASINRKILCMHGGISPKIESWDSLTGMTkpRVHGDCEHGLIVDLIWSDPNrkDDT
 .|||||| |..  .||| .| .||  |. .||.| |.|  |...| ....|.|.|||.||.|.. | .  .   |.    . | ..||.||||.  | .
tilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkirald..rlqevphegplcdllwsdpd..drg

IQFNKMRGISTLFGKSVVDNLCTTLAIDLIIRAHEMKEKGHTFEFDNRLLTVFSAPYYSGHNSNLGSVATISKSLKLRIVTLKP
      ||    ||| . ...  |  . ||.|||..  .|. . .|... |.|||| |     | ...  . ..|| .... .|
gwgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdp
subfamily_PPP4C_pd Subfamily PPP4C 21-294 6.9e-66 215.4 In-house 6-276 (288) alignment 
Range on Protein: 21-294
Range on HMM: 6-276/288.0
RIEKYGTLEGFSDSDILEVLKTIKEILEPLPCLIEIIAPVVVFGDIHGQLGDLLQFTNEVGRPPDFQYLFLGDYVDRGPNSLEVTVWLFCMKILFSKKVH
.|||  . |  ..... .. . ..|||     . .. .||.| ||||||. |||.. .  |  |. .||||||.|||| .|.|  . | ..|. . ....
qieklrrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdrit

LLRGNHEVRRVNTMYGFKEEMMRKR-NSHLWKVFNDVFAELSICASINRKILCMHGGISPKIESWDSLTGMTkpRVHGDCEHGLIVDLIWSDPNRKDdTI
|.||||| |..  .||| .|..||  ....|..  .||  ||..| |. ||.|.|||.||.|.. | .  .   | .   ..| ..||.||||. .. . 
lirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsid..rkqevphegplcdllwsdpedae.gw

QfNKMRGISTLFGKSVVDNLCTTLAIDLIIRAHEMKEKGHTFEFDNRLLTVFSAPYYSGHNSNLGSVATISKSLK
     ||   |||..||......  |.||.|||..  .|. . |....|||.||| |     |. ..  . ..|.
a.vsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeld
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 34-301 8.1e-66 215.3 In-house 9-273 (280) alignment 
Range on Protein: 34-301
Range on HMM: 9-273/280.0
SDILEVLKTIKEILEPLPCLIEIIAPVVVFGDIHGQLGDLLQFTNEVGRPPDFQYLFLGDYVDRGPNSLEVTVWLFCMKILFSKKVHLLRGNHEVRRVNT
 .|. ... .. |.     |.|  ||. | |||| |  |. .. . .|| |. . .||||||||||. .|| . |||.|| .  ...|||||||   || 
heiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnk

MYGFKEEMMRKRNSHLWKVFNDVFAELSICASINRKILCMHGGISPKIESWDSLTGMTKPrvHGDCEHGLIVDLIWSDPNRKDDTiQFNKMRGISTLFGK
.|||  |   |    ||  |. .|  . ... |....||||||.||..   |..  . .|      ..||..||.||||  | .   |  .|||| .|||
iygfyvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprp..cepldrgllidllwsdptnkgeg.wfhsirgisymfgk

SVVDNLCTTLAIDLIIRAHEMKEKGHTFEFDNRLLTVFSAPYYSGHNSNLGSVATISKSLKLRIVTLK
 ||.. | .| ||||||||.. . |. .    ||.|||| | |  . .|  .|  .   |.. .  | 
gvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqli
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 31-304 3.7e-64 209.8 In-house 6-301 (302) alignment 
Range on Protein: 31-304
Range on HMM: 6-301/302.0
FSDSDILEVLKTIKEILEPLPCLIEIIAPVVVFGDIHGQLGDLLQFTNEVGR------PPD-----FQYLFLGDYVDRGPNSLEVTVWLFCMKILFSKKV
.| |..| ..... | |.    |.|| .|| . ||||||  ||..  |.          .       ...|||||||||..|.|    .|..|.|. .. 
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

HLLRGNHEVRRVNTMYGFKEEMMR----KRNSHLWKVFNDVFAELSICASINRKILCMHGGISPKIESWDSLTGMTKPrVHGDCEHGLIVDLIWSDPNRK
 |||||||.. .|  |||.||.      |   ..|. ||.||. . . | . .||||.|||||||.||..... ...| ..   |  |  ||...||   
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrp.lkevtedslaqdllfadpldv

D--------DTIQFNKMRGISTLFGKSVVDNLCTTLAIDLIIRAHEMKEKGHTFEFDNRLLTVFSAPYYSGHNSNLGSVATISKSLKLRIVTLKPNK
.           ..| .||.| .| .. | ..|  | ..||.||| |  .|. |  |..|||.|||| |     | |.|  .    || | .|...|
qllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrnkk
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 31-303 6.9e-64 208.9 In-house 7-301 (302) alignment 
Range on Protein: 31-303
Range on HMM: 7-301/302.0
FSDSDILEVLKTIKEILEPLPCLIEIIAPVVVFGDIHGQLGDLLQFTNEVGR------PPD-----FQYLFLGDYVDRGPNSLEVTVWLFCMKILFSKKV
.| |..| ..... | |.    |.|| .|| . ||||||  ||..  |.          .       ...|||||||||..|.|    .|..|.|. .. 
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

HLLRGNHEVRRVNTMYGFKEEMMR----KRNSHLWKVFNDVFAELSICASINRKILCMHGGISPKIESWDSLTGMTKPrVHGDCEHGLIVDLIWSDPNRK
 |||||||.. .|  |||.||.      |   ..|. ||.||. . . | . .||||.|||||||.||..... ...| ..   |  |  ||...||   
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrp.lkevtedslaqdllfadpldv

D--------DTIQFNKMRGISTLFGKSVVDNLCTTLAIDLIIRAHEMKEKGHTFEFDNRLLTVFSAPYYSGHNSNLGSVATISKSLKLRIVTLKPN
.           ..| .||.| .| .. | ..|  | ..||.||| |  .|. |  |..|||.|||| |     | |.|  .    || | .|...
qllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrnk
subfamily_PPP5C_pd Subfamily PPP5C 32-299 1.4e-63 207.9 In-house 35-305 (322) alignment 
Range on Protein: 32-299
Range on HMM: 35-305/322.0
SDSDILEVLKTIKEILEPLPCLIEIIAP----VVVFGDIHGQLGDLLQFTNEVGRPP-DFQYLFLGDYVDRGPNSLEVTVWLFCMKILFSKKVHLLRGNH
    .|..|...||.|. ||.|.||  .    . | ||||||  |||   .  |.|  .  ||| ||.||||  |.|| . |...|.|. ....| ||||
hkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnh

EVRRVNTMYGFKEEMMRKRNSHLWKVFNDVFAELSICASINRKILCMHGGISPKIE-SWDSLTGMtkPRVHGDCEHGLIVDLIWSDPNRKDDTIqfNKMR
|  ..| .|||..|.  | .... ..|..||  | ..  || |.| .|||.  . . . | |  .   | . . |.||.|.|.||||...  .   . .|
esdnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrki..drnaqppeegllvellwsdpqeanGrs..pskr

GISTLFGKSVVDNLCTTLAIDLIIRAHEMKEKGHTFEFDNRLLTVFSAPYYSGHNSNLGSVATI-SKSLKLRIVT
|... ||  | .... .  ..||||.||.||.|. .| | .|.|||||| |  . .|.|.. |. .. |||.. |
GvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfkt
PPP_5_Dcr2 60-255 2.3e-63 206.8 In-house 1-199 (199) alignment 
Range on Protein: 60-255
Range on HMM: 1-199/199.0
VVVFGDIHGQLGDL-LQFTNEVGRPP-DFQYLFLGDYVDRGPNSLEVTVWLFCMKILFSKKVHLLRGNHEVRRVNTMYGFKEEMMRK-RNSHLWKVFNDV
|.|.||.||||.|| |.. .|.|.|. . .|.|||||||||..||||...|...|... |.||||||||| . .| .|||..|...|  .....|...||
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FAELSICASINRKILCMHGGISPKIESWDSLTGMTKPrVHGDCEHGLIVDLI-WSDPNRKDDTIQFNKMRGISTLFGKSVVDNLCTTLAIDLIIRAHEMK
| .|...| |..|.|..|||.||.|.|...|  .... ..   |.|   ||. ||||... .... |. ||...|||..|.......  ..||||.||.|
fdwlPlaalidekvlvvhgglspeiksiellekierk.ieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 36-310 4e-63 206.5 In-house 8-281 (284) alignment 
Range on Protein: 36-310
Range on HMM: 8-281/284.0
ILEVLKTIKEILEPLPCLIEIIAPVVVFGDIHGQLGDLLQFTNEVGRPPDFQYLFLGDYVDRGPNSLEVTVWLFCMKILFSKKVHLLRGNHEVRRVNTMY
.  .|    .|..  | |||. .|. . ||||||. |||.. .. | |   .|||||||||||   ||  . ||. |..| ... .||||||.  .| .|
vetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinkiy

GFKEEMMRKRNS-HLWKVFNDVFAELSICASINRKILCMHGGISPKIESWDSLTGMTKPRVHGDCeHGLIVDLIWSDPNRKDDTIQFNkMRGISTLFGKS
|| ||  |. |   ... |. ||... . | . ..|||||||.|  ..    |  . .|    .    | .|..||||   .   . |  ||.| .||  
gfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpep.ntlaidilwsdptnfqkgwnpn.srgvsyvfgsd

VVDNLCTTLAIDLIIRAHEMKEKGHTFEFDNRLLTVFSAPYYSGHNSNLGSVATISKSLKLRIVTLKPNKGYDRSK
 . .|   | |||..|||.. . |. |  . ||.|.||||.| |.  |  .|  . | |   .| |.| |   | .
alrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrprkkiarrr
subfamily_PPP3C_pd Subfamily PPP3C 31-291 5.4e-63 206.3 In-house 41-311 (452) alignment 
Range on Protein: 31-291
Range on HMM: 41-311/452.0
FSDSDILEVLKTIKEILEPLPCLIEIIAPVVVFGDIHGQLGDLLQFTNEVGRPPDFQYLFLGDYVDRGPNSLEVTVWLFCMKILFSKKVHLLRGNHEVRR
......|.....  ..|.  . |.|. ||..| ||||||  |||.. .  | | . .|||||||||||  |.|. ..|...|| ......||||||| | 
leeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrh

VNTMYGFKEEMMRKRNSHLWKVFNDVFAELSICASINRKILCMHGGISPKIESWDSLTGMTkpRVHGDCEHGLIVDLIWSDPNRK------DDTIQFNKM
.   . ||||.  | . .... . . |  | . | .|.. ||.|||.||.|.| |..  .   | .   ..|.. ||.||||  .      ... . |..
lteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkld..rfkeppasGplcdllWsdPledygeekteekfvpnsv

RGISTLFGKSVVDNLCTTLAIDLIIRAHEMKEKGHTFEFDN------RLLTVFSAPYYSGHNSNLGSVATISK
|| | ... . | ..  .  .  |||||| ...|..   ..       |.|.|||| | .  .| ..|  . .
rGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyen
subfamily_PPP6C_pd Subfamily PPP6C 29-293 1.3e-62 204.6 In-house 13-274 (290) alignment 
Range on Protein: 29-293
Range on HMM: 13-274/290.0
EGFSDSDILEVLKTIKEILEPLPCLIEIIAPVVVFGDIHGQLGDLLQFTNEVGRPPDFQYLFLGDYVDRGPNSLEVTVWLFCMKILFSKKVHLLRGNHEV
. ....|. .. ......|     .  . .|| | ||||||. ||... .  |. || .|.||||.||||  |||    |...|. . ... ||||||| 
kylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhes

RRVNTMYGFKEEMMRKR-NSHLWKVFNDVFAELSICASINRKILCMHGGISPKIESWDSLTGMTkpRVHGDCEHGLIVDLIWSDPNRKDDTIQfnKMRGI
|..  .||| .| ..|  |.  || . .||  |.|.| |. ..||.|||.||...  |... ..  | .   ..| ..||.||||.  ..  .    || 
rqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvie..raqeiphkgafcdlvwsdpedvetwav..sprga

STLFGKSVVDNLCTTLAIDLIIRAHEMKEKGHTFEFDNRLLTVFSAPYYSGHNSNLGSVATISKSL
  |||..|.......  ..||.|||.. |.|  . ||..| ||.||| |     |. |. ..... 
gylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledae
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 33-304 1.9e-61 201.0 In-house 25-296 (297) alignment 
Range on Protein: 33-304
Range on HMM: 25-296/297.0
DSDILEVLKTIKEILEPLPCLIEIIAPVVVFGDIHGQLGDLLQFTNEVGRPPDFQYLFLGDYVDRGPNSLEVTVWLFCMKILFSKKVHLLRGNHEVRRVN
.  .|..|    ....    ..|. ||. | ||||||. |||..    | ||  .|||||||||||  |.|  | |.. |. |  .. |||||||.  ||
eervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecefvn

TMYGFKEEMMRKRN-SHLWKVFNDVFAELSICASINRKILCMHGGISPKIESWDSLTGMTKPRVHGDCEHGLIVDLIWSDPNRKDDTIqFNKMRGISTLF
 .||| ||  .. .  ...  |.|||  | ..  |  ||||||||.|| .    .|  . |     . . .|. ||.|.||      . ... ||    |
kvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierstegkerlvadllwadpisglsgf.menqrgagcgf

GKSVVDNLCTTLAIDLIIRAHEMKEKGHTFEFDNRLLTVFSAPYYSGHNSNLGSVATISKSLKLRIVTLKPNK
|.  | .||. . .||. |||.. . |. |    .|.|.||||.| |.  |  .. .  . |.  .  |.|  
grdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilrpts
subfamily_PPG1_pd Subfamily PPG1 23-293 3.4e-61 200.1 In-house 6-286 (300) alignment 
Range on Protein: 23-293
Range on HMM: 6-286/300.0
EKYGTLEGFSDSDILEVLKTIKEILEPLPCLIEIIAPVVVFGDIHGQLGDLLQFTNEVGRPPDFQYLFLGDYVDRGPNSLEVTVWLFCMKILFSKKVHLL
||    | . .. . |. . .||.|     .||| .|| | ||.|||. |.|.  .  |. || .|||||||||||  |.|  . | ..|. .  ...||
eklqkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritll

RGNHEVRRVNTMYGFKEEMMRKR--NSHLWKVFNDVFAELSICASINRKILCMHGGISPKIESWDSLTGMTkpRVHGDCEHGLIVDLIWSDPN-------
||||| |..  .|||  | .||   ||..|| . ..|  |...| |. .| |.|||.||.. | | .  .   | .   ..| . ||.||||.       
rgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvld..rfrevpnegaladllwsdpeennnptl

-RKDDTI-QF-NKMRGISTLFGKSVVDNLCTTLAIDLIIRAHEMKEKGHTFEFDNRLLTVFSAPYYSGHNSNLGSVATISKSL
 . |.   .| .  ||    .||.|| ..  .  .. |||||..  .|.   |||.| ||.||| |     |  |.  . . .
dhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekd
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 39-304 1.3e-58 191.6 In-house 28-293 (307) alignment 
Range on Protein: 39-304
Range on HMM: 28-293/307.0
VLKTIKEILEPLPCLIEIIAPVVVFGDIHGQLGDLLQFTNEVGRPPDFQYLFLGDYVDRGPNSLEVTVWLFCMKILFSKKVHLLRGNHEVRRVNTMYGFK
|.   . |.    .|..|  |.|| ||.|||. ||...   .||||.  |.| |||||||  |||. . ||..|| ..... |||||||. |||  ||| 
viyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygfy

EEMM---RKRNSHLWKVFNDVFAELSICASINRKILCMHGGISPKIESWDSLTGMTKPRvhGDCEHGLIVDLIWSDPNRKDDTIQfNKMRGISTLFGKSV
|| .    |    .| .|. .| .| | | |  ||||||||.|| .   | |    ||    .   |.. |..|.||.      .    ||    ||  |
eecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpi..rnpfrgivndmlwadpdpsvfewk.assrgsgftfgtnv

VDNLCTTLAIDLIIRAHEMKEKGHTFEFDNRLLTVFSAPYYSGHNSNLGSVATISKSLKLRIVTLKPNK
.|..|  | ..||||||.|   |.      .|.|.|||| |     | | |  . ..| ...|.. |. 
iddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpes
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 87-303 1.2e-53 175.4 In-house 121-334 (339) alignment 
Range on Protein: 87-303
Range on HMM: 121-334/339.0
QYLFLGDYVDRGPNSLEVTVWLFCMKILFSKKVHLLRGNHEVRRVNTMYGFKEEMMRKRNSHLWKVFNDVFAELSICASINRKILCMHGGISPKIESWDS
.|||||||||||| |.|| . | ..|. .  ...||||||| | ||| |||  |.  . ...|...|...|  . .|| ||  |.||||||| .. |.. 
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfnq

LTGMTKPRVHGDCehGLIVDLIWSDPNRKDDTIQfNKMRGISTLFGKSVVDNLCTTLAIDLIIRAHEMKEKGHTFEFDNRLLTVFSAPYYSGHNSNLGSV
.. . .|    |   |.. || |.||.  .   .    || | .||   .  .   | ....|| |.. | |. |    ||.|.|||| | |.| |  .|
fsvfkrpleipdv..gvltdltwadpdptekgyk.psargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaav

ATISKSLKLRIVTLKPN
 .| | ||. |  ..|.
fsidkklkisinvfrpe
subfamily_PPPLV_pd Subfamily PPPLV 52-302 1.6e-48 158.5 In-house 18-287 (290) alignment 
Range on Protein: 52-302
Range on HMM: 18-287/290.0
CLIEIIAPVVVFGDIHGQLGDLLQFTNEVGRPP-D---FQYLFLGDYVDRGPNSLEVTVWLFCMKILFSKKVHLLRGNHEVRRVNTMYGFKEEMMRKRNS
 |.|. .|. |.||.||.  ||  | . . |   |    ..||||||||||. |.|.  .|. .|.|.  ||.|||||||.. |   . .| | . |   
rllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqesieykgegsfkfgd

H---LWKVFNDVFAELSICASINRKILCMHGGISPKIESWDSLTGM--TKPRVHGDCEH-GLIVDLIWSDPNRKDDT-----------IQFNKMRGISTL
.    |. ||.||  | . | |.||..|.|.||   | .   .. .     |.. | .   | .|..||||. . |              .|. || . .
sleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvlneGfvdndrrGtghv

FGKSVVDNLCTTLAIDLIIRAHEMKEKGHTFEFDNRLLTVFSAPYYSGHnSNLGSVATISKSlKLRIVTLKP
|..  ....     .. ..||||.||||  .  . |||||||.  | |  ||  ..  ..|. ||||.|  |
fsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGs.sneaalilvdkk.klriittgp
Metallophos Calcineurin-like phosphoesterase 59-255 5.7e-39 127.4 Pfam-A 2-199 (200) alignment 
Range on Protein: 59-255
Range on HMM: 2-199/200.0
PVVVFGDIHGQLGDL----LQFTNEVGRPPDFQYLFLGDYVDRGPNSLEVTVWL--FCMKILFSKKVHLLRGNHEVRRVNTMYGFKEEMM----------
...|.||.||.| ||    |.. .  ....   .|||||.||||..|.|.   |  .. |.|....|.|||||||.. .|. |||..|.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------RKRNSHLWKVFNDVFAELSICASINRKILCMHGGISPKIESWDSLtgmtkprvhgdcehglivdliwsdpnrkddt
                         ... . .  ....|..|...| .. |||..||..|.  .|.|                                 
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

iqfnkmrgISTLFGKSVVDNLCTTLAIDLIIRAHEMK
         |.|||. ....|.    .||..|.|. |
........gselfgpdalekllekygvdlvlrGHtHk
subfamily_PPP7C_pd Subfamily PPP7C 35-181 1e-33 109.6 In-house 37-191 (383) alignment 
Range on Protein: 35-181
Range on HMM: 37-191/383.0
DILEVLKTIKEILEPLPCLIEII----APVVVFGDIHGQLGDLLQFTNEVGRP-PDFQYLFLGDYVDRGPNSLEVTVWLFCMKILFSKKVHLLRGNHEVR
 .|..|.  |..|. || . ..       | | ||.||.| |||      | | ..  |.| ||.|||| .|.|. . |... ... |.|.| |||||  
yvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedh

RVNTMYGFKEEMMRKR---NSHLWKVFNDVFAELSICASINRKILCMHGGISPKI
 .|  |||  |.. |    .... ....|||| | ... |..||| .||||| | 
ilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdkt
subfamily_PPP7C_pd Subfamily PPP7C 200-314 3.3e-21 68.5 In-house 233-346 (383) alignment 
Range on Protein: 200-314
Range on HMM: 233-346/383.0
EHGLIVDLIWSDPNRKDdTIQFNKMRGISTLFGKSVVDNLCTTLAIDLIIRAHEMKEKGHTFEFDNRLLTVFSAPYYSGHNSNLGSVATISKSLKLRIVT
|   ..|..||||. |.   . | .||  . ||  | ..| .   ..|.||.|| | .|. |  |...||.|||  |  . || |.   ..|.|. ||| 
ewrqvldilwsdpkake.GckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivq

LKPNKGYDRSKLDKR
 . .|   .. | .|
yqaskatkkltlrqr
subfamily_YNL217W_pd Subfamily YNL217W 60-145 2e-08 27.0 In-house 12-99 (235) alignment 
Range on Protein: 60-145
Range on HMM: 12-99/235.0
VVVFGDIHGQLGDLLQFTN--EVGRPPDFQYLFLGDYVDRGPNSLEVTVWLfcmkilFSKKVHLLRGNHEVRRVN------TMYGFKEEMMRKR
..| ||.||   .|... .  ..|. ..   ...|| ...||.|.||  ..       ...|. ..||||   .          |...  . ..
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllaykwvkkpkgaeplefssk
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 31-83 1.9e-06 20.3 In-house 9-61 (317) alignment 
Range on Protein: 31-83
Range on HMM: 9-61/317.0
FSDSDILEVLKTIKEILEPLPCLIEIIAPVVVFGDIHGQLGDLLQFTNEVGRP
|......|.    .|..   |  .|. ||| . ||||||  ||| . .  | |
fkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwp
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 28-83 4.1e-06 19.1 In-house 8-63 (339) alignment 
Range on Protein: 28-83
Range on HMM: 8-63/339.0
LEGFSDSDILEVLKTIKEILEPLPCLIEIIAPVVVFGDIHGQLGDLLQFTNEVGRP
|. |  ... |. .  .|..   | .... ||..|.||||||. ||| . .  | |
ldlfcaaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmngwp
Chitin_synth_1 Chitin synthase 105-155 9.6e-06 11.9 Pfam-A 83-132 (163) alignment 
Range on Protein: 105-155
Range on HMM: 83-132/163.0
TVWLFCMKILFSKKVHLLRGNHEVRRVNTMYGFKEEMMRKRNSHLWkVFND
 .. .  ..  ... .. . ....  |  .. .||.  .| |||.| .|| 
hiyeyttqlsidenlkfkgkekglvPvqllfclkeknqkkinshrW.lfna