Gene C30A5.4 in Caenorhabditis elegans

Synonym: CELE_C30A5.4, C30A5.4

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily CelePPP-sf2
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP029_AA protein Get Run
CeleP029_AA_126-357 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 191-370 4.5e-133 436.2 In-house 128-307 (307) alignment 
Range on Protein: 191-370
Range on HMM: 128-307/307.0
TECVTSIPKCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFRGIVNDMLWADPDPSVFEWKTSSRGSGFTFGTNVIDD
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||
eecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgtnvidd

VCKRLGVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNTGCVLKVDETLGIQTVAFVPESENIEKIIEEMNRVW
||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||.|||||||||||||||| ||||
vckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpeseniekiieeknrvw
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 190-358 3.6e-100 327.8 In-house 115-280 (281) alignment 
Range on Protein: 190-358
Range on HMM: 115-280/281.0
FTECVTsipKCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFRGIVNDMLWADPDPSVFEWKTSSRGSGFTFGTNVID
. ||||   |.|||.|||||||||.||||||||...|||||||||.||.||||||.||||||..||.|.|.||||||..|.|||.|||||.||||.||.|
yvecvt...kyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfGknvvd

DVCKRLGVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNTGCVLKVDETLGIQTVAFVPESEN
||||||.|||||||||...|||.|||||||||.||.|.||.||||...||||||||||..||.||.||.
dvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpasep
0045823 Metallo-dependent phosphatases 129-357 1.2e-61 201.9 In-house 41-326 (473) alignment 
Range on Protein: 129-357
Range on HMM: 41-326/473.0
MHYTKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGNLHGQFNDLINMFILLGRPPETVYVFT-------------------------ECVT--------
  ...|.. ....||. |...|. |.......||.| .|||. ||.... ..|.|||. .||.                         ..|.        
gllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkikypgnvfllrGNHEl

------------SIPKCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFRGIVNDMLWADPDPSVFE-------WKTSS
             . | ||...  |......||..|.|  |||..|||||| |. ||..|....|.  |  |.. |.||.||..   .       .  | 
rllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdPweddgdgllrlrffgnsp

RGSGFTFGTNVIDDVCKRLGVELIIRAHQMCFDGYWVLSGRK------LITIFSAPMYCNFYKNTGCVLKVDETLgIQTVAFVPESE
|| |..|| .......|. |. ||.|.|... .||..| ..|      .||.|||| ||. ..| ..||..||.| |. . | | . 
rgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsph
0049330 Metallo-dependent phosphatases 127-356 2.6e-59 194.0 In-house 26-300 (309) alignment 
Range on Protein: 127-356
Range on HMM: 26-300/309.0
HKMHYTKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGNLHGQFNDLINMFILLGRPPETVYVFT-----------ECVT--------------------
.   ...||. .....|..|. ||. |.... ..||.| .|||. ||.... ..| |||. .||.           |...                    
klkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkllypdnvfllrGNH

--------------SIPKCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFRGIVNDMLWADPDPSVFEWKTSSRGSGF
               . | |.|.|  |......||. |.|  ||||.|||||| |. ||..|.  .|.. |  |...|.||.||.| . ..  . || |.
ElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpiregfapnprglgv

TFGTNVIDDVCKRLGVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNTGCVLKVDETLGIQTVAFVPES
.|| .......|..|..||||.|...|.|| .. ..||||.|||| ||. ..| |.||..||.| |. . | | .
vfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvp
0053225 Metallo-dependent phosphatases 127-353 1e-53 175.8 In-house 18-289 (293) alignment 
Range on Protein: 127-353
Range on HMM: 18-289/293.0
HKMHYTKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGNLHGQFNDLINMFILLGRPPETVYVFT-----------ECVTSIPKC---------------
. .....||.  ...||..|...|. |.... ...|.| .||.. ||.... ..| |||. .||.           |... . ..               
llkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllypdnvvllrGNH

--------------------GEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFRGIVNDMLWADPDpSVFEWKTSSRGSG
                    ..|.|  .......||..|||  |||..|||||| |. ||..|.  .|.| |..|...|.|| |||  ...| .| || |
ElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpd.lwsgwlpsyrglg

FTFGTNVIDDVCKRLGVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNTGCVLKVDETLGIQTVAFV
..|| .......|. |..||||.||...|||... ..||.|.|||| |.. ..| |.||..|| | .. . | 
vvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfa
PP2Ac_SM00156 199-354 4.8e-53 172.9 In-house 114-269 (271) alignment 
Range on Protein: 199-354
Range on HMM: 114-269/271.0
KCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFRGIVNDMLWADPDPSVFEWKTSSRGSGFTFGTNVIDDVCKRLGVE
| |.||.. |...|. ||..||. .||||||||||| |. ||..|.. .. ..| .|.. |.||.||. .. ... |.|| ...||........|.. ..
kygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFgedavkeflkknnlk

LIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNTGCVLKVDETLGIQTVAFVP
||||||... .|| . . .||.||||||.||. ..|...||||...| .. . . .
liiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlke
subfamily_PPP1C_pd Subfamily PPP1C 199-350 4.4e-52 170.0 In-house 123-274 (282) alignment 
Range on Protein: 199-350
Range on HMM: 123-274/282.0
KCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFRGIVNDMLWADPDPSVFEWKTSSRGSGFTFGTNVIDDVCKRLGVE
. . ..|  |. .|| ||..||.. ||||.|||||| |. |...|.  .|.. | .|.. |.||.||| .| .|....||. ||||..|.......  ..
rysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsftfgkdvvekflqkndld

LIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNTGCVLKVDETLGIQTV
||.||||.  |||   . |.|.|.|||| ||. ..|.|.||.|||.| ..  
livrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfq
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 203-356 4.6e-52 169.9 In-house 142-295 (298) alignment 
Range on Protein: 203-356
Range on HMM: 142-295/298.0
EIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFRGIVNDMLWADPDPSVFEWKTSSRGSGFTFGTNVIDDVCKRLGVELIIR
...| ||  || ||. |||...|||||||||. |. ||.||.  .|. ..   ...|.|||||. .| .|...||| ...||..|. |....| ..|..|
rlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenavkgwaensrGvsvvfGedvvkdllekldidlvvr

AHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNTGCVLKVDETLGIQTVAFVPES
|||.  |||  ....||.|||||| ||. ..|. .|.|||| | .  . . ||.
ahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpek
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 203-355 5.9e-51 166.5 In-house 142-294 (299) alignment 
Range on Protein: 203-355
Range on HMM: 142-294/299.0
EIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFRGIVNDMLWADPDPSVFEWKTSSRGSGFTFGTNVIDDVCKRLGVELIIR
 .|..|| .|. .|.. ||...|||||||||| |. || ||. ..|   |   .  |.|||||| || .|..  ||  . || .|. ||..||...|. |
rlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgvsyvfgqdvvadvisrldidlvar

AHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNTGCVLKVDETLGIQTVAFVPE
|||.  |||  .. .||.|||||| ||  . |. ...|||| |    | . | 
ahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkpt
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 107-191 5.7e-49 159.9 In-house 1-80 (307) alignment 
Range on Protein: 107-191
Range on HMM: 1-80/307.0
VEFLDRHYQVMQAGvstvkVHKMHYTKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGNLHGQFNDLINMFILLGRPPETVYVFT
|.||||||||.|||     |||..||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||
vdfldrhyqviqag.....vhkiqytkeefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvft
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 199-356 1.6e-48 158.6 In-house 159-316 (317) alignment 
Range on Protein: 199-356
Range on HMM: 159-316/317.0
KCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFRGIVNDMLWADPDPSVFEWKTSSRGSGFTFGTNVIDDVCKRLGVE
.  ....  ||  || ||..|... ||||||||.|  |. |..| .  .|.  |  |.. |. |||||..|  .| |.||.|. ||.. ... .|.| ..
rysaalyeafqlafnvlplcavvnkkilcmhGGiseelldlkqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldld

LIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNTGCVLKVDETLGIQTVAFVPES
|..||||.  |||  ...|||.||||||.||   .|...||.||. | |    . |||
lvvrahqvvedGyeffadrklvtifsapsycGqldniaavlsvdkklkisinvlrpes
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 196-354 2.8e-45 147.9 In-house 116-274 (280) alignment 
Range on Protein: 196-354
Range on HMM: 116-274/280.0
SIPKCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFRGIVNDMLWADPDPSVFEWKTSSRGSGFTFGTNVIDDVCKRL
   | |  .|  || ||| .|.|.||. ..||||||||| |  || .|| |.|.    ||.. |.||.||      |  | ||  . ||  |... || |
cqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkgvveqacksl

GVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNTGCVLKVDETLGIQTVAFVP
 ..|||||||.  ||| ...||.|||.|| | ||  . |. .|. ..  | .    ..|
eidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlip
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 202-355 4.3e-45 147.0 In-house 122-275 (280) alignment 
Range on Protein: 202-355
Range on HMM: 122-275/280.0
EEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFRGIVNDMLWADPDPSVFEWKTSSRGSGFTFGTNVIDDVCKRLGVELII
..... ||  ...||. ||.. .|||||||||. |  ||.|..  .|. ..   . .|.|||||.  |  |  .|||    || ||. |....| ..||.
lalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifganvvkdltekldidlia

RAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNTGCVLKVDETLGIQTVAFVPE
| ||.  |||  ....||.|.|||| |.. ..|. .||.||| | .    . |.
rghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpa
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 188-350 4.3e-44 144.1 In-house 118-278 (284) alignment 
Range on Protein: 188-350
Range on HMM: 118-278/284.0
Y-VFTECVTsipKCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFRGIVNDMLWADPDPSVFEWKTSSRGSGFTFGTN
|  ..||.    .  | ..  || .|| .|..|... ||.|||||.|  |  |..| .  .||  |  |.. |. ||||. .|. .| | ||.| .||..
ygfyleckk...rysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesprgagkvfgak

VIDDVCKRLGVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNTGCVLKVDETLGIQTV
 ... .|.  ..|..||||.  |||  .. |||.||||||.||  ..| ..||.||| | .  .
avkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasft
PPP_3 192-350 7.9e-44 142.7 In-house 111-267 (271) alignment 
Range on Protein: 192-350
Range on HMM: 111-267/271.0
ECVtsIPKCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFRGIVNDMLWADPDPSVFEWKTSSRGSGFTFGTNVIDDV
|..    | |....  .|..|. ||..|||  |.|..||||||... ||....  ..|. | .| . | |. ... .   ...|.|| |..||..| ...
evl..kkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFgpdvteef

CKRLGVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNTGCVLKVDETLGIQTV
...  ..||||||... .|| .|  .|..|.|||| ||. ..|.|..||..|.|  ...
leknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefk
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 199-356 8.6e-41 132.7 In-house 123-283 (287) alignment 
Range on Protein: 199-356
Range on HMM: 123-283/287.0
KCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPF--RGIVNDMLWADPDPSVFEWKT-SSRGSGFTFGTNVIDDVCKRL
| .|...  |.  |..||. | .. .|||||||.|| |  ||.|.  .||  .    .|.. |.|||||.      ..   |.    || ...||..|.|
krqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisvvfGkkevddllkkl

GVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNTGCVLKVDETLGIQTVAFVPES
...||.|||..  .||  |  ..|.|.|||| |.    |.|.|..|...| .. | . || 
didlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkped
subfamily_PPP2C_pd Subfamily PPP2C 201-355 1.9e-40 131.9 In-house 133-286 (290) alignment 
Range on Protein: 201-355
Range on HMM: 133-286/290.0
GEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFRGIVNDMLWADPDpSVFEWKTSSRGSGFTFGTNVIDDVCKRLGVELI
  ..| .|   |. ||..||.  .|.|.||||||....||..|.  .    |  | . |.||.|||     | .| ||.|.||| .. ..  |. |..||
nanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpd.drggwgisprgagytfgkdisekfnktngltli

IRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNTGCVLKVDETLGIQTVAFVPE
.||||....|| ..  |...|||||| ||.   | ...|..|..|  . . | | 
arahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpa
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 203-357 5.2e-40 130.6 In-house 182-336 (339) alignment 
Range on Protein: 203-357
Range on HMM: 182-336/339.0
EIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFRGIVNDMLWADPDPSVFEWKTSSRGSGFTFGTNVIDDVCKRLGVELIIR
...  ||  || .|. |.|   |.|||||.|  || ....    .|.  |  |.. |. ||||||.   .| |.||. | ||   .  . |.| ....||
qlyecfqnmfnvfpfcavinntimcmhggisehltsfnqfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvir

AHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNTGCVLKVDETLGIQTVAFVPESE
 ||.  ||| .. ||.|.|||||| ||    || .|. .|. | |    | ||| 
ghqvvedgyeffdgrrlvtifsapnycgqndntaavfsidkklkisinvfrpesr
subfamily_PPZ_pd Subfamily PPZ 199-345 1.3e-39 129.5 In-house 138-284 (300) alignment 
Range on Protein: 199-345
Range on HMM: 138-284/300.0
KCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFRGIVNDMLWADPDPSVFEWKTSSRGSGFTFGTNVIDDVCKRLGVE
.|  .||  |   || ||..|..| ||.|.|||||| | ..||.|   .|   |  |..||.||.||  |  ||.   ||  . .    |. . ...|..
rcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvsycynkvainkflnkfgfd

LIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNTGCVLKVDETL
|. ||| .  ||| ..  | |.|.|||| ||  . | |.|. | | |
lvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegl
subfamily_PPP4C_pd Subfamily PPP4C 202-348 2.2e-38 125.1 In-house 133-278 (288) alignment 
Range on Protein: 202-348
Range on HMM: 133-278/288.0
EEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFRGIVNDMLWADPDPSVfEWKTSSRGSGFTFGTNVIDDVCKRLGVELII
 ..| .  . |. |...|.|  ||.|.|||||| .. |||.|   . .  |  |.. |.||.||.     | .| ||.|. ||..|... ... ..|||.
anvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedae.gwavsprgagylfgsdvveqfneandielic

RAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNTGCVLKVDETLGIQ
||||.  .|| .   .|..|..||| ||    |   .|..||.|  .
rahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkd
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 204-347 5.7e-38 123.9 In-house 142-287 (297) alignment 
Range on Protein: 204-347
Range on HMM: 142-287/297.0
IWALFQRCFNNLPISALIATKILCMHGGLSPALT---CLDELRNHPKPIrNPFRGIVNDMLWADPDPSVFEWKTSSRGSGFTFGTNVIDDVCKRLGVELI
..| ||  || ||.. ||||||||||||||| ||   .|| ||.  ..  .   ..| |.|||||   .  .    ||.|  || . . ..|  . ..|.
myaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierst.egkerlvadllwadpisglsgfmenqrgagcgfgrdavlklcsefkldlv

IRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNTGCVLKVDETLGI
 ||||.  ||| ...||||.|||||| ||  . |  ... .|| |  
crahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqc
PPP_1 197-340 1.4e-37 122.4 In-house 113-263 (264) alignment 
Range on Protein: 197-340
Range on HMM: 113-263/264.0
IPKCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFRGIVNDML-------WADPDPSVFEWKTSSRGSGFTFGTNVID
  |...||. ... .|. ||..|||  |||..|||||| |. ||. |.  . .. | .| ..| |       . |.. .   ...| || |..||..|..
kkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRGagylfgkdvte

DVCKRLGVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNTGCVLK
..... ...||||||... .|| .|. ||..|||||. |..  .|.| ..|
kflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 189-344 3.4e-36 117.9 In-house 122-289 (302) alignment 
Range on Protein: 189-344
Range on HMM: 122-289/302.0
VFTECVTS--IPKCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFR-GIVNDMLWADPDPS--------VFEW-KTSS
 | | .     .| | |||  |. .|  .|..||.  ||||.|||.|| |..|.....  .|. .     . .|.|.|||             .. |   
gfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvqllaavsekPkyakniv

RGSGFTFGTNVIDDVCKRLGVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNTGCVLKVDET
||  ..|    . ||||||...||.|||||   |.   . .||.|||||| | |   |.| |||||  
rglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtn
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 189-344 4.7e-36 117.5 In-house 123-290 (302) alignment 
Range on Protein: 189-344
Range on HMM: 123-290/302.0
VFTECVTS--IPKCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFR-GIVNDMLWADPDPS--------VFEW-KTSS
 | | . .   .| | |||  |. .|  .|..||.  ||||.|||.|| |..|.....  .|. .     . .|.|.|||             .. |   
gfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvqllaavsekPkyakniv

RGSGFTFGTNVIDDVCKRLGVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNTGCVLKVDET
||  ..|    . ||||||...||.|||||   |.   . .||.|||||| | |   |.| |||||  
rglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtn
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 203-354 1.1e-35 116.4 In-house 121-273 (284) alignment 
Range on Protein: 203-354
Range on HMM: 121-273/284.0
EIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFR-GIVNDMLWADPDPSVFEWKTSSRGSGFTFGTNVIDDVCKRLGVELII
 ..  |.  | ..|..||.  .|||||||.|  |  . .||   .|. ||    .  |.||.||      |.  |||  . ||.. .  .  || ..|..
svyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsdalrklldrlqidlvv

RAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNTGCVLKVDETLGIQTVAFVP
||||.  ||| ... |.|.||||||.||  . |. .|. |.. |    | . |
rahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrp
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 187-354 1.4e-35 115.7 In-house 119-288 (290) alignment 
Range on Protein: 187-354
Range on HMM: 119-288/290.0
VYVFTECVTSipKCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPI--RNPFRGIVNDMLWADPDP---SVFEWKtSSRGSGF
.| | | ..   | | ..|  .|  |..|.. | .. ||||||||.|. .   . |.   ||    .  .|.. |.|||||.      .. .   |.   
lygfkeelar..krgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialn.kqraisv

TFGTNVIDDVCKRLGVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNTGCVLKVDETLGIQTVAFVP
 || ...||..|.|...||.|||..  .|.  |  .||.|.|||| |.    | |....| |.| .. |.. |
vfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkp
subfamily_PPP6C_pd Subfamily PPP6C 192-352 4.5e-35 114.2 In-house 124-281 (290) alignment 
Range on Protein: 192-352
Range on HMM: 124-281/290.0
ECVTSIPKcgEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFRGIVNDMLWADPDpSVFEWKTSSRGSGFTFGTNVIDDV
||..   .   . |  . . |. |.|.|.|  ..||.|||||| .. ||..|   . .  |..| . |..|.||.  | .|..|.||.|. ||..| .. 
eclnkygn..anawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpe.dvetwavsprgagylfgskvtkef

CKRLGVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNTGCVLKVDETLGIQTVAF
..   ..||.||||.  .|.      ||.|..||| ||    |  ..|.....   ..  |
vhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklf
subfamily_PPP5C_pd Subfamily PPP5C 187-349 4.7e-33 107.5 In-house 142-305 (322) alignment 
Range on Protein: 187-349
Range on HMM: 142-305/322.0
VYVFTECVTSipKCGEEIWALFQRCFNNLPISALIATKILCMHGGLSP-ALTCLDELRNHPKPIRNPFRGIVNDMLWADPDPSVFEwKTSSRGSGFTFGT
.| |.. |..  |  |..  ||.. || ||.. .|  |.| .||||       ||.||.  .  ..|  |.. ..||.||...    ..|.|| |..|| 
lyGfegevka..kytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqeanGr.spskrGvgvqfGp

NVIDDVCKRLGVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNTGCVLKV---DETLGIQT
.| .  .|  ..|||||.|..  .|| |    ||||.|||| ||.   | |.....   |..| ..|
dvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfkt
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 202-357 1.5e-31 103.0 In-house 101-258 (263) alignment 
Range on Protein: 202-357
Range on HMM: 101-258/263.0
EEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNP-FRGIVNDMLWADPDPSV--FEWKtSSRGSGFTFGTNVIDDVCKRLGVE
| ..  |.. |. .|. |... .|||||||.|| |  ||..|  | |.     . .  |.|||||.     || .   |     || . .||.|||| ..
esvynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepn.kiraisnvfgkkevddlckrldid

LIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNTGCVLKVDETLGIQTVAFVPESE
||.||||.   || ... |.|||.|||  |     |  .|. |.. | .  | . ||  
livrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkpedf
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 125-191 6.1e-31 100.7 In-house 2-68 (281) alignment 
Range on Protein: 125-191
Range on HMM: 2-68/281.0
KVHKMHYTKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGNLHGQFNDLINMFILLGRPPETVYVFT
..||..|||||.||||.|...|||.|||||.||.|.||||.||.|||||...|.||||.||.|.||.
nihkvqytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvfl
subfamily_PPG1_pd Subfamily PPG1 190-346 9e-30 96.9 In-house 121-287 (300) alignment 
Range on Protein: 190-346
Range on HMM: 121-287/300.0
FTECVTSIPkCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFRGIVNDMLWADPD---------PSV--FEWKTSSRG
.|||.         .|  .   |. | ..|.|  .| |.||||||.  ..|...   .    |  | . |.||.||.         |     ... | ||
yteclrkyg.gnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqhfvvsqrg

SGFTFGTNVIDDVCKRLGVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNTGCVLKVDETLG
.|...| .|.    .   .. ||||||.| .|| .|   || |..||| ||.   |   .|.. | . 
agysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekde
PPP_2 192-306 4e-27 88.2 In-house 81-197 (198) alignment 
Range on Protein: 192-306
Range on HMM: 81-197/198.0
ECVtsIPKCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFRGIVNDML----WADPDPSVFEWKTSSRGSGFTFGTNV
|..    | |....  .|..|. ||..|||  |.|..|||||.... ||. ... ..|. | .| ..| |    . ||. .   ...|.|| |..||..|
evl..kkkggkkvykklqevfelLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdv

IDDVCKRLGVELIIRAHQM
.......  ..||||||..
teelleknklkliiRaHev
subfamily_PPP3C_pd Subfamily PPP3C 199-343 2e-26 85.8 In-house 154-311 (452) alignment 
Range on Protein: 199-343
Range on HMM: 154-311/452.0
KCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNPFRGIVNDMLWADPDPSVFEWK-------TSSRGSGFTFGTNVIDDV
| .||..  . ..|..||..||.  . ||.|||||| .. ||....  .    | .| . |.||.||     | |        | ||  . .. . . . 
kyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpnsvrGcsyfysykavcef

CKRLGVELIIRAHQMCFDGYWVLSG------RKLITIFSAPMYCNFYKNTGCVLKVDE
 ..  .  |||||.   .|| .           |||.|||| |.. |.| . |||...
lqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyen
PPP_4 188-306 2.5e-25 82.7 In-house 78-196 (197) alignment 
Range on Protein: 188-306
Range on HMM: 78-196/197.0
YVFTECVTsiPKCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNP-FRGIVNDM-LWADPDPSVFEWKTSSRGSGFTFGT
| |.. |.   | |.||.  .|..|. ||..|||. |.|..|||||. |. ||..... ..|. |  ..  .|. ||.|| ..   .. | || |..|| 
ygfkkevl..ekhgkeilkklqdvfdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgp

NVIDDVCKRLGVELIIRAHQM
.|....... ...||||.|..
dvtekfleknnlkliirshel
PPP_5_Dcr2 189-306 4.6e-24 78.5 In-house 79-198 (199) alignment 
Range on Protein: 189-306
Range on HMM: 79-198/199.0
VF-TECVTSIpkCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALTCLDELRNHPKPIRNP-FRGIVNDM-LWADPDPSVFE-WKTSSRGSGFTFG
 | .|...     |..|.  ....|. ||..|||. |.|..|||||| .  ...|..  ..|. |  .|  .|. ||.|| ... . .  | || |..||
gftkevlsky..hgkkiykilsdvfdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfg

TNVIDDVCKRLGVELIIRAHQM
 .|....... ...||||.|..
pdvtekfleknnlkliirshel
subfamily_PPPLV_pd Subfamily PPPLV 190-344 4.6e-21 68.4 In-house 108-279 (290) alignment 
Range on Protein: 190-344
Range on HMM: 108-279/290.0
FTECVTSIPKCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPALT---CLDELRNHPKPIRNPFRG--IVNDMLWADPDP-------------SVFE
 .|.     .  ||.|  |. .|. ||..| |  |..|.|.|.  |      .  ... .. ....  |  .  |.||.||.                | 
kgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvlneGfv

WKtSSRGSGFTFGTNVIDDVCKRLGVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNTGCVLKVDET
   ..|| |  |... ..   || ... ..|||..   |. .  . .|.|.||.  ||    .. ..|   . 
dn.drrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssneaalilvdkkk
subfamily_PPP7C_pd Subfamily PPP7C 257-355 7.8e-17 54.0 In-house 237-335 (383) alignment 
Range on Protein: 257-355
Range on HMM: 237-335/383.0
VNDMLWADPDPSVFEWKTSSRGSGFTFGTNVIDDVCKRLGVELIIRAHQMCFDGYWVLSGRKLITIFSAPMYCNFYKNTGCVLKVDETLGIQTVAFVPE
| |.||.||      .  . ||.|  ||..| ... .. ...|.||.|.  ..|| .   .|..|||||  | .   | |  .|. ..|  . | .. .
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqyqas
PP2Ac_SM00156 132-191 5.1e-15 48.2 In-house 2-61 (271) alignment 
Range on Protein: 132-191
Range on HMM: 2-61/271.0
TKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGNLHGQFNDLINMFILLGRPPETVYVFT
.|||. ... |...|...||.||....|..|||..|||..||.... | |.|||. ||| 
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFl
subfamily_PPP3C_pd Subfamily PPP3C 131-190 8.8e-14 44.1 In-house 41-100 (452) alignment 
Range on Protein: 131-190
Range on HMM: 41-100/452.0
YTKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGNLHGQFNDLINMFILLGRPPETVYVF
 ..|.  ..| || .....||.|.... | .|.|..|||| ||...| . | | .| |.|
leeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylf
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 117-190 2.1e-13 43.0 In-house 11-83 (298) alignment 
Range on Protein: 117-190
Range on HMM: 11-83/298.0
MQAGVSTVKVHKMhYTKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGNLHGQFNDLINMFILLGRPPETVYVF
.....|. |. |.  ..|. |..| .|. ||.. |.||..|.|  | |..|||..||. .|   | ||.. |.|
lsvslsekkltkv.ikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylf
subfamily_PPP1C_pd Subfamily PPP1C 127-190 9.1e-13 41.0 In-house 6-69 (282) alignment 
Range on Protein: 127-190
Range on HMM: 6-69/282.0
HKMHYTKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGNLHGQFNDLINMFILLGRPPETVYVF
.... ...| |... .|..|. |. .|.... |  .||..|||..||...|   | |||. |.|
kevklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylf
PPP_3 131-190 2.7e-12 39.2 In-house 2-61 (271) alignment 
Range on Protein: 131-190
Range on HMM: 2-61/271.0
YTKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGNLHGQFNDLINMFILLGRPPETVYVF
....|..... ... |...|. ||.|. | .|.| .|||..||...|   |..||| |.|
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlF
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 135-191 1.3e-11 37.2 In-house 10-66 (280) alignment 
Range on Protein: 135-191
Range on HMM: 10-66/280.0
EFENVIYEAQTIFSSEKALVDIDPPCVVVGNLHGQFNDLINMFILLGRPPETVYVFT
. ..|| . . |.. ....|..| |  |.|.||||..||. .|   . ||.. |.| 
didrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylfl
subfamily_PPZ_pd Subfamily PPZ 115-191 2.5e-11 36.7 In-house 9-85 (300) alignment 
Range on Protein: 115-191
Range on HMM: 9-85/300.0
QVMQAGVSTVKVHKMHYTKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGNLHGQFNDLINMFILLGRPPETVYVFT
....|| .. . ...   ..|  .. ..|. .| .. ||... |.  .||..|||..||. .|   | || . |.| 
klldagyaakrtknvclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylfl
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 115-191 2.7e-11 36.3 In-house 9-84 (299) alignment 
Range on Protein: 115-191
Range on HMM: 9-84/299.0
QVMQAGVSTVKVHKMhYTKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGNLHGQFNDLINMFILLGRPPETVYVFT
.... | |  .. |    ..|. ..   |...| |. .|.....| .|.|..|||. ||. .|   | ||.. ..| 
kllnvgmsekrltks.vkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflfl
Metallophos Calcineurin-like phosphoesterase 198-306 2.8e-11 37.1 Pfam-A 126-198 (200) alignment 
Range on Protein: 198-306
Range on HMM: 126-198/200.0
PKCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPAL-TCLDElrnhpkpirnpfrgivndmlwadpdpsvfewktssrgSGFTFGTNVIDDVCKRLG
|. | .... ....|..||. ||.  |||..||.||. . ...|.                                      .. || .. .. ... |
pllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi.....................................gselfgpdalekllekyg

VELIIRAHQM
| |..|.|. 
vdlvlrGHtH
PPP_1 132-191 1e-10 34.4 In-house 2-61 (264) alignment 
Range on Protein: 132-191
Range on HMM: 2-61/264.0
TKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGNLHGQFNDLINMFILLGRPPETVYVFT
..||  ... ........|. |.... .  |.| .||||.||...|   | .||| |.| 
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFl
subfamily_PPP2C_pd Subfamily PPP2C 131-191 1.6e-10 33.7 In-house 17-77 (290) alignment 
Range on Protein: 131-191
Range on HMM: 17-77/290.0
YTKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGNLHGQFNDLINMFILLGRPPETVYVFT
 ...| .... .|. |.|.|. . ..  |  |.|..|||| ||...| . |. |.| |.| 
leesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylfl
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 131-190 2.7e-10 32.6 In-house 10-69 (287) alignment 
Range on Protein: 131-190
Range on HMM: 10-69/287.0
YTKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGNLHGQFNDLINMFILLGRPPETVYVF
.. ..  .|. ... |.   .||.... | ..||..|||..||...|   |..|.. |.|
fsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylf
subfamily_PPP4C_pd Subfamily PPP4C 130-191 3.2e-10 32.7 In-house 15-76 (288) alignment 
Range on Protein: 130-191
Range on HMM: 15-76/288.0
HYTKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGNLHGQFNDLINMFILLGRPPETVYVFT
. ..|| ...  .|. |.  |  .  .| | .| |..||||.||...| . |  ||| |.| 
likeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylfl
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 127-177 3.5e-10 32.6 In-house 3-53 (302) alignment 
Range on Protein: 127-177
Range on HMM: 3-53/302.0
HKMHYTKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGNLHGQFNDLINMF
.| .|.|.|.  .| .    .. ||.|..| ||  .||..||||.||. ..
rkkeysksellllieaviellkkektlaeispPvtivGdihGqfedlvril
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 128-177 4.5e-10 32.2 In-house 3-52 (302) alignment 
Range on Protein: 128-177
Range on HMM: 3-52/302.0
KMHYTKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGNLHGQFNDLINMF
| .|.|.|.  .| .    .. ||.|..| ||  .||..||||.||. ..
kkeysksellllieaviellkkektlaeispPvtivGdihGqfedlvril
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 131-184 1.1e-09 30.9 In-house 9-62 (317) alignment 
Range on Protein: 131-184
Range on HMM: 9-62/317.0
YTKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGNLHGQFNDLINMFILLGRPP
....|. .. | |. .| .|.  .... |  .||..||||.||. .. | | | 
fkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwpl
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 131-191 1.8e-09 30.1 In-house 16-76 (290) alignment 
Range on Protein: 131-191
Range on HMM: 16-76/290.0
YTKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGNLHGQFNDLINMFILLGRPPETVYVFT
.. ..  ... ... |.    ||...  | |.||..|||...|...|  .|.||.  ..| 
fsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflfl
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 132-191 6.9e-09 28.4 In-house 24-83 (297) alignment 
Range on Protein: 132-191
Range on HMM: 24-83/297.0
TKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGNLHGQFNDLINMFILLGRPPETVYVFT
|.|   ...  |  .| ..|..|... |  |.|..|||| ||. .|   | || . |.| 
teervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylfl
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 131-183 8e-09 28.3 In-house 8-60 (284) alignment 
Range on Protein: 131-183
Range on HMM: 8-60/284.0
YTKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGNLHGQFNDLINMFILLGRP
....|. .. | |. .|  ||  ..|. |  .||..||||.||. .. | | |
lkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwp
subfamily_PPG1_pd Subfamily PPG1 139-191 1.4e-08 27.4 In-house 22-74 (300) alignment 
Range on Protein: 139-191
Range on HMM: 22-74/300.0
VIYEAQTIFSSEKALVDIDPPCVVVGNLHGQFNDLINMFILLGRPPETVYVFT
...  . .. .|  ...|  |  |||..|||| |....| . |. |.| |.| 
ltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylfl
subfamily_PPP6C_pd Subfamily PPP6C 131-191 7.3e-08 24.9 In-house 15-75 (290) alignment 
Range on Protein: 131-191
Range on HMM: 15-75/290.0
YTKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGNLHGQFNDLINMFILLGRPPETVYVFT
 ........    . ... | ... .  |  |.|..|||| || ..|   |. |.| ||| 
lpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvfl
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 133-191 7.6e-08 25.1 In-house 5-63 (284) alignment 
Range on Protein: 133-191
Range on HMM: 5-63/284.0
KEEFENVIYEAQTIFSSEKALVDIDPPCVVVGNLHGQFNDLINMFILLGRPPETVYVFT
 |. | ....| .||  .  |.... |  ..|..|||| ||. .|   | |  . |.| 
pedvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylfl
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 132-190 1.4e-07 24.2 In-house 7-65 (280) alignment 
Range on Protein: 132-190
Range on HMM: 7-65/280.0
TKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGNLHGQFNDLINMFILLGRPPETVYVF
|  |  ..|   ..||  |  |.. . |  |.|..| |..|.  .| |.|| ||   .|
tgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmf
subfamily_PPP5C_pd Subfamily PPP5C 124-190 2.4e-07 23.1 In-house 28-98 (322) alignment 
Range on Protein: 124-190
Range on HMM: 28-98/322.0
VKVHKMHYTKeEFENVIYEAQTIFSSEKALVDIDPP----CVVVGNLHGQFNDLINMFILLGRPPE-TVYVF
.| .|.  .|    ... ||....... .||.|. .      | |..|||| ||.|.| | |.| |   |.|
fkkqkklhkk.yalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylf
PHA-1 Regulator protein PHA-1 111-181 6.6e-07 14.6 Pfam-A 262-334 (390) alignment 
Range on Protein: 111-181
Range on HMM: 262-334/390.0
DRHYQVMQAG--VSTVKVHKMHYTKEE--FENVIYEAQTIFSSEKALVDIdPPCVvVGNLHGQFNDLINMFILLG
..    .|..  . .. .....  ..   |.|.|  ...||...|  |.. | .. .    ......|.... . 
eeveidlqfsellaktleeelkkseslsdfdniiaNvkriFptkkltveL.pkel.illalvnlekfikkllemi
subfamily_PPP7C_pd Subfamily PPP7C 190-240 2.1e-06 19.7 In-house 144-194 (383) alignment 
Range on Protein: 190-240
Range on HMM: 144-194/383.0
FT-ECVTSIPKCGEEIWALFQRCFNNLPISALIATKILCMHGGLSPAlTCLD
|. |  .  .. |..| .|..  |  ||...||  ||| .|||.|   | |.
fikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdk.tdle
PPP_2 161-191 2.6e-06 20.2 In-house 2-32 (198) alignment 
Range on Protein: 161-191
Range on HMM: 2-32/198.0
VVVGNLHGQFNDLINMFILLGRPPETVYVFT
.|.| ||||..||...|   ...||. |.| 
tvcGDlHGqldDLlilfknglpsperkylFl
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 131-183 2.7e-06 19.7 In-house 11-63 (339) alignment 
Range on Protein: 131-183
Range on HMM: 11-63/339.0
YTKEEFENVIYEAQTIFSSEKALVDIDPPCVVVGNLHGQFNDLINMFILLGRP
.   |. .. . |. .  ||  .. .. | .|.|..||||.||. |. . | |
fcaaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmngwp
T4_neck-protein Virus neck protein 104-164 3.2e-06 12.9 Pfam-A 131-191 (231) alignment 
Range on Protein: 104-164
Range on HMM: 131-191/231.0
IDFVEFLDRHYQVMQAGVSTVKVHKMHYTKEEFENVIYEAQTIFSSEKALVDIDPPCVVVG
| |||  |  ||. .  |  .|..|  |..||..  . | ..|   |.| .|...   . |
ikfveaedPfyqlgknyvyklkaekFiYsgeeikpevdeieeinieelaeldlalvknldG
subfamily_PPPLV_pd Subfamily PPPLV 141-176 5.5e-06 18.9 In-house 7-42 (290) alignment 
Range on Protein: 141-176
Range on HMM: 7-42/290.0
YEAQTIFSSEKALVDIDPPCVVVGNLHGQFNDLINM
  |  |. .|. |.... |. |.|.|||...||| .
dvavdilaaeerllelksptyvlgdlhgnyrdliyf
FNIP_M Folliculin-interacting protein middle domain 73-147 6.1e-06 13.3 Pfam-A 4-80 (233) alignment 
Range on Protein: 73-147
Range on HMM: 4-80/233.0
RLTKKMAKNSERRKKMAHGPEMTAQNRTQERIDFVEFLDRHYQVMQAGVSTVK--VHKMHYTKEEFENVIYEAQTIF
. .... .. ...||.| .  .  .....| ..| .||  |  .. . .. ..  ..|. ..|..| . |.|| . |
eesssssaakrkkkklalaviislseskeeemkfeqflleHfvlleselkklrkaiekasakkqqflqlilealekf