Gene C42C1.2 in Caenorhabditis elegans

Synonym: CELE_C42C1.2, C42C1.2

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1H
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP034_AA protein Get Run
CeleP034_AA_79-519 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1H_pd Subfamily PPM1H 82-519 3.9e-179 588.6 In-house 1-403 (404) alignment 
Range on Protein: 82-519
Range on HMM: 1-403/404.0
LCPRFPHRMPLYVGYAEAINAGKTVQNEDQASAKMLVLTQHqgnemngfssDEKKSETRKRnsnendddpmltpggddteKSSMFAPRADGALFSLFDGH
|.||  .|.|...||||.|||||...|||||.||.|.|...          ...||.|.|.                   |......... |.|.|||||
lvprelrrlPwaaGYaevinagkselneDqaaakvlllkke..........kkeksvtskp...................kekseeeklplayfglfDGh

AGSAVAVVASKCLHEHVKSRLCEVLDTILHMDRHENLNFGKHRSESSYSMSEMSreDENRIRSEHLVKGALETAFLDMDEQIAQDKQVWRLPGGCAVISV
|||..|.||||.||.|.|..|..||...|.....|. |......||..|.||..  .|..|..|.||.||||.|||.||||||.... .|..|||.....
aGsgaalvaskllhkhlkekledvlellleksaeeeenteesskespssvseiy..eekeiskeeLviGalesaflemDeqiarereayrikGGCtalva

LVFLGKLYIANAGDCRAILVTSDGSRALSKDLTPASERKRLQELAYRNPELIGNSFSRLEYSKRLTIHDLKSRVLYRDWFMDGWAVKTVKECDLRPSLIS
||.|||||.|||||.|||||..| ...||.|.||..||.||||||...|||.|..|.|||..|||...||..||||||. |.|||.|||.|.||. .|||
lvllgklYvanaGDsRailvrkdeiiplsadftPeteRqRlqelaflkPeLlgkeftrlefqkRlkkkdlgqrvlyRdqnmtGWayktveeeDlkfplis

ETSRKKRLLNTIGVSRGFGDHHLLTVDERLSIKPFLSAVPEISVTNLRDMNTLTDKdVVIVASDGLWDVLSNEDAGLIVRSTLGSTDSADPSRYTQAAQD
....|.|||.||||.||.|||.| .||..||||||||.|||..|..|.....|.|. |.|.|.||||||||||... |||..| .....|..|||..||.
gegkkaRllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDd.vlilatDGLWdvlsneevaeivrevlskvepedkkrytavaqe

LVAAARGQQASGNlkrWVMNTGGHASYDDITVFVIPLK
|||||||.... .   |.......||.|||.|||||||
LvaaarGklkdkg...WrlkeekaasvDDisvfviPlk
PP2Cc_SM00332 147-516 5.6e-62 202.6 In-house 15-274 (274) alignment 
Range on Protein: 147-516
Range on HMM: 15-274/274.0
NDDDPMLTPGGDDTEKSSMFAPRADGALFSLFDGHAGSAVAVVASKCLHEHVKSRLCEVLDTIlhmdrhenlnfgkhrsessysmsemsredenrirsEH
...... ... |..     . ...|...|..||||.||.|| ..||.|.|..|..|....|.                                    |.
ssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdel...................................ed

LVKGALETAFLDMDEQIAQDKQVWRL----PGGCAVISVLVFlGKLYIANAGDCRAILVTSDGSRALSKDLTP--ASERKRLQELAYrnpelignsfsrl
 |. ||..|||..||.| ...|...|     | .||...|.  ..||.||.||.||.|.... ...||.| .|  ..||||... ..             
dveealkkaflstdeeileeeqskelenalsGstavvallkk.edlyvanvGDSravlcrngkavqlsvdhkpedederkRikkagg.............

eyskrltihdlksrvlyrdwfmdgwavktvkecdlrpsliseTSRKKRLLNTIGVSRGFGDHHLLTVDerLSIKPFLSAVPEISVTNLrdmntLTDKDVV
                                          . .|.|. ... ||| ||||.| . .   . .|...| |...|..|      ......
..........................................vvekgrvngglavsrafGdhflkknk..klkepyitaepdvkvvtl.....tsedefl

IVASDGLWDVLSNEDAGLIVRSTLGSTdsaDPSRYTQAAQDLVAAARGQqasgnlkrwvmntggHASYDDITVFVI
|.|||||||||||...  |||..| ..      ....||..|...|. .               . |.|.|||.|.
ilaSDGlwdvlsnqevvdivrkllakg...ktndpqeaaelldeeairr...............ggseDniTvvvv
0034914 PP2C-like 80-519 3.3e-48 157.0 In-house 7-291 (295) alignment 
Range on Protein: 80-519
Range on HMM: 7-291/295.0
PVLCPRFPHRMPLYVGYAEAINAGKTVQNEDQASAKMlvltqhqgnemngfssdekksetrkrnsnendddpmltpggddteksSMFAPRADGALFSLFD
|.| ... . ..|.. .. | . |.   |||. .. .                                               ...    |..|| .||
pllellllsslllllrvgvasdqGrrksneDavlvvl...............................................nllslledlllfgvfD

GHAGSAVAVVASKCLHEHVKSRLCEVLDTILHMdrhenlnfgkhrsessysmsemsredenrirsEHLVKGALETAFLDMDEQIAQDKQV--WRLPGGCA
|| |.|.| |||. |.|.... | ..| .  .                                 .. .. ||..||| .||.. .  .    .. .|. 
GhgGhaaaevasellvelllellekllllltls................................ledieealrkaflaadeellelallrpelagsGtT

VISVLVFLGKLYIANAGDCRAILVTSDGSRALSKDLTP--ASERKRLQELAyrnpelignsfsrleyskrltihdlksrvlyrdwfmdgwavktvkecdl
.. .|.. .|||.||.||.||.|....  . |..| .|   .||.|....                                                  
avvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsag.................................................

rpslisETSRKKRLLNTIGVSRGFGDHHLLTVDERLSIKPFLSAVPEISVTNLRdmntLTDKDVVIVASDGLWDVLSNEDAGLIVRSTLGSTDSadpsrY
      .. .  |..... |.| .||..|...  .| ..|..||.|...|..|     | | |....||||||||||||..  ||||.| ....     .
......gavshgrvngvlavtRalGdfdlklllslllleplvsaePdvtvlelt....ledddfllLasDGlwdvlsneeivdivrsllakgld.....l

TQAAQDLVAAARGqqasgnlkrwvmntggHASYDDITVFVIPLK
..||. || .|                  . |.|.|||.|. |.
eeaaeeLvdlAla................rgsrDNiTvvvvrln
0049733 PP2C-like 154-518 3.6e-30 98.1 In-house 24-233 (235) alignment 
Range on Protein: 154-518
Range on HMM: 24-233/235.0
TpggddtekssmfapraDGALFSLFDGHAGSAVAVVASKCLHEHVKSRLCEvldtILHMDrhenlnfgkhrsessysmsemsredenrirsehlVKGALE
                 ...|| ..||| |.|.. |||..|.|.... |.|     |..|                                  .. ||.
v................glllfavaDGhgghaagevasellvetllellle....lllld..................................leealr

TAFLDMDEQIAQDKQVW--RLPGGCAVISVLVFLGKLYIANAGDCRAILVTSDGSRALSKDLTPASERKRLQELAYRNPElignsfsrleyskrltihdl
 ||| ..|.. .  . .  .  .|. .. .|.. ||||.||.||.||.|....  . |..| .|. |  |   .....                      
kaflaaneallelalaspelagmgtTavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav....................

ksrvlyrdwfmdgwavktvkecdlrpslisetsrkkRLLNTIGVSRGFGDHHLLtvderlsikpflsavPEISvtnlrdMNTLTDKDVVIVASDGLWDVL
                                    | .. . ..| .||..|                |...      . .|.. |....|||||||||
....................................rvpgrlaltralGdlllk...............pdvt......vlelepgdflllasDGlwdvl

SNEDAGLIVRStlgstdsadpSRYTQAAQDLVAAARGqqasgnlkrwvmntggHASYDDITVFVIPL
|.|..  ..||            . .||. || .|.                 . ..|.||| |. |
sdeeivdllrs..........ldleeaaerlvelala................rggrDNiTvvvvrl
subfamily_PPM1A_pd Subfamily PPM1A 165-323 1.8e-22 73.0 In-house 35-166 (282) alignment 
Range on Protein: 165-323
Range on HMM: 35-166/282.0
MFAPRADGALFSLFDGHAGSAVAVVASKCLHEHVKSrlcevldtilhmdrhenlnfgkhrsessysMSEMSReDENRIRSEHLVKGALETAFLDMDEQIA
 .. ..|...|..||||||| || ...|.|.|.. .                               .|..   . . .... || ||...||..||.| 
slgalkdwsfFavfDGHaGsevakyvkkhllenile..............................eeelke.aaleasekdevkealrqgfLaldeair

QDKQVWR--LPGGCAVISVLVFLGKLYIANAGDCRAILVTSDGSRALSKDLTPAS--ERKRLQ
....  .  .  |. ...|||   .|.|||.||.||.|.    .  |..|  | .  |.||..
elstdlktadksGsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRie
subfamily_PPM1G2_pd Subfamily PPM1G2 171-322 3.8e-19 61.7 In-house 51-165 (287) alignment 
Range on Protein: 171-322
Range on HMM: 51-165/287.0
DGALFSLFDGHAGSAVAVVASKCLHEHVKSrlcevldtilhmdrhenlnfgkhrsessysmsemsredeNRIRSEHLVKGALETAFLDMDEQIAQDKQVW
. |||..|||| |..||  |.| |.. ...                                       ..  .|  .. .|. |||..||.. .|... 
slalfavfDGhGGakvakyagkklikkiak.......................................kksfkegaleqilkdafletDeellkdeklk

RLPGGCAVISVLVFLGKLYIANAGDCRAILVTSDGSRALSKDLTPAS--ERKRL
    |.  ..||.   |||.||||| ||.| ..  ..||| |  | .  |.||.
desaGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkri
PP2C Protein phosphatase 2C 165-353 2.4e-16 53.1 Pfam-A 28-181 (255) alignment 
Range on Protein: 165-353
Range on HMM: 28-181/255.0
MfAPRADGALFSLFDGHAGSAVAVVASKCLHEHVKSRLCEVLDTilhmdrhenlnfgkhrsessysmsemsredenrirsehLVKGALETAFLD-MDEQI
.  .. . |.|  ||||.|. .| .|.. |.|..|..     ..                                      .|. ||  .||  .||..
s.sgkssvaffavfdghggreaakyarehleeilkeqksflele......................................kvekalrksfladtdeel

AQDKQV-WRLPGGCAVISVLVFLGKLYIANAGDCRAILVTSDGSR-ALSKDLTPA--SERKRLQELAYRNPElIGNSFSRLEYSKRLTIHDLKS
...|.    .  |.  ...|..  |||.||.||.||.|...|... .|..| .|.  .||.|..|.  .  . .|  .  |. |. |  ..||.
ksskantepsksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn.ngrvngsLavsRalGdfelkp
PP2C Protein phosphatase 2C 165-353 2.4e-16 53.1 In-house 28-181 (255) alignment 
Range on Protein: 165-353
Range on HMM: 28-181/255.0
MfAPRADGALFSLFDGHAGSAVAVVASKCLHEHVKSRLCEVLDTilhmdrhenlnfgkhrsessysmsemsredenrirsehLVKGALETAFLD-MDEQI
.  .. . |.|  ||||.|. .| .|.. |.|..|..     ..                                      .|. ||  .||  .||..
s.sgkssvaffavfdghggreaakyarehleeilkeqksflele......................................kvekalrksfladtdeel

AQDKQV-WRLPGGCAVISVLVFLGKLYIANAGDCRAILVTSDGSR-ALSKDLTPA--SERKRLQELAYRNPElIGNSFSRLEYSKRLTIHDLKS
...|.    .  |.  ...|..  |||.||.||.||.|...|... .|..| .|.  .||.|..|.  .  . .|  .  |. |. |  ..||.
ksskantepsksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn.ngrvngsLavsRalGdfelkp
subfamily_PDP_pd Subfamily PDP 167-307 5.2e-16 51.7 In-house 20-185 (398) alignment 
Range on Protein: 167-307
Range on HMM: 20-185/398.0
APRADGALFSLFDGHAGSAVAVVASKCLHEHVKSRL--CEVLDTI-LHMDRHEN----LNFGKHRSESSYSMSEMSREDENRI-------RSEHLVKGAL
  ...| ||..||||.| | |   || | ..|   |   .|| ..  ..  ...    |.  ||. .. . ...   ..|..         . . || ||
llesngvlfgvfDGHggaacaeavskrLlkyvaasllkkqvleeaekalesgkallkllkkskhkldvvsdeakklslselskylqelleaevekvkeal

ETAFLDMDEQIAQDKQ-------VWR-----LPGGCAVISVLVfLGKLYIANAGDCRAILVTSDGSR
..|||..|..|... .       . .     | | ||.....    .|..||.|||||.| ..... 
kkaFlklDkdistealkklkekslreallvalsGacallalie.gtelhvAntGDcravlgvqeeeg
PP2C Protein phosphatase 2C 385-492 8.3e-15 48.0 Pfam-A 160-252 (255) alignment 
Range on Protein: 385-492
Range on HMM: 160-252/255.0
RKKRLLNTIGVSRGFGDHHLLTVDerlsiKPFLSAVPEISVTNLRDmntltDKDVVIVASDGLWDVLSNEDAGLIVRSTLGSTDsadpsRYTQAAQDLVA
...|. ... ||| .||..|   .     ... || |......| .     . . .|.||||||||||...|  .|||.| ...       ..||..|| 
nngrvngsLavsRalGdfelkpke.....eqlvsaePdvtsvklte.....edefliLasdGlwdvlsdqeavdlvrselskkk.....spmeaaeelvd

AARGQQAS
 |  ....
eaiargse
PP2C Protein phosphatase 2C 385-492 8.3e-15 48.0 In-house 160-252 (255) alignment 
Range on Protein: 385-492
Range on HMM: 160-252/255.0
RKKRLLNTIGVSRGFGDHHLLTVDerlsiKPFLSAVPEISVTNLRDmntltDKDVVIVASDGLWDVLSNEDAGLIVRSTLGSTDsadpsRYTQAAQDLVA
...|. ... ||| .||..|   .     ... || |......| .     . . .|.||||||||||...|  .|||.| ...       ..||..|| 
nngrvngsLavsRalGdfelkpke.....eqlvsaePdvtsvklte.....edefliLasdGlwdvlsdqeavdlvrselskkk.....spmeaaeelvd

AARGQQAS
 |  ....
eaiargse
PPM_PTC7 237-323 1.8e-14 46.8 In-house 59-153 (259) alignment 
Range on Protein: 237-323
Range on HMM: 59-153/259.0
EDENRIRSEH--LVKGALETAFLD--MDEQIAQDKQV-WRLPGGCAVISVLVFLGKLYIANAGDCRAILVTSDGSR-ALSKDLTPASE--RKRLQ
  ..|.. |   ... || ..||   .|| . ....    . .|.  ...|..  |||.||.||.||.|..|.... .|..| .|..|  |.|..
ilkerksfeeleklekalrksflaldtdeelksseantepstsGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRie
subfamily_PPM1A_pd Subfamily PPM1A 387-494 7.9e-14 44.6 In-house 175-272 (282) alignment 
Range on Protein: 387-494
Range on HMM: 175-272/282.0
KRLLNTIGVSRGFGDHHLLTVDERLSIKPFLSAVPEISVTNLRDmntltDKDVVIVASDGLWDVLSNEDAGLIVRSTLGSTDSADPSrytqaAQDLVAAA
.|.  .. ||| .||... . .|. . .  .||.||. ...  .     ..| ...|.||.|||||.|..  .||..|. .| .        |..||  |
sRvnGaLAvsRalGDyeykeeeekkaeeqlvsaepevtsierse.....eddflvlacDGiwDvlsdeevvelvrkrlevadeleev.....akalvdka

RGQQASGN
  . .  |
lekgsrDN
PPM_PTC7_SpoIIE 222-483 8e-14 45.0 In-house 42-213 (230) alignment 
Range on Protein: 222-483
Range on HMM: 42-213/230.0
KHRSESSYSMSEMSREDENRIRSEH-LVKGALETAFLDMDEQIAQDkqvwRLPGGCAVISVLVFLGK--LYIANAGDCRAILVTSDGSralskdltpase
 |   ... |...    ..... .. ... .|. ..| .. ..  .       .|. .. .|..  .  ||.|||||....||..||             
GhGgraalamgllrtalrelafaglekpeeilrrlnlalaadlede....psssgaTavvalidpstgklyvanaGdsppllvrddgg............

rkrlqelayrnpelignsfsrleyskrltihdlksrvlyrdwfmdgwavkTVKECDLRPSL------IsetsrkkRLLNTIGVSRGFGDHHLLTvderls
                                                  ...  ..   .              |   .  ||. .||  ||       
..................................................ererivagglpslGilpg.......rvfgvlavslapGdlllly......

ikpflsavpeiS--VTNLR--DMNTLTDK--DVVIVASDGLWDVLSNEDAGLIVRSTLGSTdsadpsrytqaaqdlV
           .  |.  .  .. ....   . .|.||||||||||....  .||..|..                .
...........tDGvveaepdtsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp...............a
PPM_PTC7 382-489 3e-13 42.8 In-house 161-253 (259) alignment 
Range on Protein: 382-489
Range on HMM: 161-253/259.0
ETsRKKRLLNTIGVSRGFGDHHLLTVDErlsIKPFLSAVPEISVTNLRDmntltDKDVVIVASDGLWDVLSNEDAGLIVRSTLGSTdsadpsRYTQAAQD
.  .. |. ... ||| |||..|         .. .|| |.||.|.. .     . . .|.||||||||.|...|  .|||.| ..        . ||..
nv.gngrvngvlavsRafGdfelkpket...eeqlvsaePdisstkide.....edefliLasdGlwdvvsdqeavdlvrselskk......dpmeaaek

LVAAARGQ
||  |  .
lvdeaiar
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 250-463 1.3e-12 40.5 In-house 75-223 (255) alignment 
Range on Protein: 250-463
Range on HMM: 75-223/255.0
GALETAFLDMDEQIaqdkQVWRLPGGCAVISVLVFLGKLYIANAGDCRAILVtsdgsralskdltpaserkrlqelayrnpelignsfsrleyskrltih
 .|. |. ... ||    . .    |.. .|||.   | |||| || |..|                                                 
kslkkaykeistqi....serpkfiGttaasvliiedkvyianvGdsrvvlc................................................

dlksrvlyrdwFMDGWAVKTvkECDLRPSLISETSRKKRL----LNTIGVSRGFGDHHLLTVDERLSIKPFLSAVPEISVtnlrDMNTLTDKDVVIVASD
             || |..     | .||  ||. | ..|    ..|   ||  |   .        ..||. . |..|      ... ...  .|.| |
...........qkdgtakrl..sldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsflePfvvpdPdlsq....sleiskkdkflilacd

GLWDVLSNEDAGLIVRST
|.||..|.|.|  || . 
Giwdlisdeeaveivagi
subfamily_TAB1_pd Subfamily TAB1 164-326 6.6e-11 34.6 In-house 18-186 (333) alignment 
Range on Protein: 164-326
Range on HMM: 18-186/333.0
SMFAPRADGA-LFSLFDGHAGSAVAVVASKCLHEHVKSRlcEVLDTILHMDRHENLNFGKHRSESSYS--MSEMSrEDENRIRSeHLVKGALE-TAFLDM
....   ..  |...|||. |. .| .. . |  ..     ...|...... .| |.   .. | ..   . ..  .... ..| .| .|  .  ..   
vflfktendpilyavFdGydGnkaakfveqrLvaellle..qltdelaeaevkevlkrafeeverkflesiddal.aekddlqs.qlPegvssyeleeqy

DEQIAQDKQV-WRLPGGCAVISVLVFLGKLYIANAGDCRAILVT---SDGSRALSKDLTPA--SERKRLQELA
.|.| . ...   . || . . .|.|  |||.||.|| ||.||.   |.  . ||.| |     | .||..| 
pekierlqeleeeisgGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLG
subfamily_PPM1L_pd Subfamily PPM1L 172-323 2.6e-10 33.0 In-house 35-158 (269) alignment 
Range on Protein: 172-323
Range on HMM: 35-158/269.0
GALFSLFDGHAGSAVAVVASKCLHEHVKSRLCEVldtilhmdrhenlnfgkhrsessysmsemsreDENRIRSEHLVK-GALETAFLDMDEQIAQD-KQV
  .|..|||| |   |  | . | . .|..| |.                                |... ..| .     |.   | .||.. .  |. 
esffavfdGhGGefaaefakdvlvkaiknkliel................................dadkentepinfsklltdeilsvdekllekakra

WRLPGGCAVISvLVFLGKLYIANAGDCRAILVTSDGSR-ALSKDLTPA--SERKRLQ
  . |  |.|. ||   .| .|| || | .|.  .|    || |  |    ||||..
ediaGttalia.lvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrik
PPM_PTC7_motif 441-494 9.1e-10 31.9 In-house 1-50 (51) alignment 
Range on Protein: 441-494
Range on HMM: 1-50/51.0
IVASDGLWDVLSNEDAGLIVRSTLGSTDSadpsRYTQAAQDLVAAARGQQASGN
| ||||||||||...|  .||..| ..      ....||..||  |...  . |
iLAsDGLWDvlsdqeavdlvrdqlskkgl....spqeaAeklvdealargseDn
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 388-467 1.2e-09 30.5 In-house 176-245 (276) alignment 
Range on Protein: 388-467
Range on HMM: 176-245/276.0
RLLNTIGVSRGFGDHHLLTVDERLSIKPFLSavPEISVTNLrdmntltdKDVVIVASDGLWDVLSNEDAGLIVRSTLGST
  .| . ||| .||| .   .  |. .|..|  ..|..|          .. .||||||||||.| .||  .|.|     
trinGlavsralGdhfikelniGlisepyvs..nrilltpf........dkflivasdGlwdvisGkdaiekvkslydqq
subfamily_KAPP-like_pd Subfamily KAPP-like 388-467 1.2e-09 30.6 In-house 166-235 (266) alignment 
Range on Protein: 388-467
Range on HMM: 166-235/266.0
RLLNTIGVSRGFGDHHLLTVDERLSIKPFLSavPEISVTNLrdmntltdKDVVIVASDGLWDVLSNEDAGLIVRSTLGST
  .| . ||| .||| .   .  |. .|..|  ..|..|          .. .||||||||||.| .||  .|.|     
trinGlavsralGdhfikelniGlisepyvs..nrilltpf........dkflivasdGlwdvisGkdaiekvkslydqq
PPM_PTC7_SpoIIE_motif 433-516 1.6e-08 28.1 In-house 8-78 (81) alignment 
Range on Protein: 433-516
Range on HMM: 8-78/81.0
TLTDKDVVIVASDGLWDVLsNEDAGLIVR----STLGSTDSADpsrYTQAAQDLVAAARGqqasgnlkrwvmnTGGHASYDDITVFVI
.|  .||.....|||..   ..| .|.      ... . .. .     ..|. ||....              .|.. . ||||..|.
qLkpgdvllLyTDGltEar.dsdgelfgkeellrladraegks...lqeladklvdevle.............ngsgereDDitllvl
subfamily_PPM1G2_pd Subfamily PPM1G2 387-469 2.1e-08 26.5 In-house 175-252 (287) alignment 
Range on Protein: 387-469
Range on HMM: 175-252/287.0
KRLLNTIGVSRGFGDHHLLTVDERLSIKPFLSAVPEISVTNLRDmntltDKDVVIVASDGLWDVLSNEDAGLIVRSTLGSTDS
.|  ... .|| .||..  . ..  .      |||.. |..|..     |.. ...| ||.||||.|..   .||. | |  .
nrvngnLalsralgDfefkknvkkkpeeqivtavPDvlvkklde.....ddeflvLaCDGiWDvltnkevvdlvrerlvsgak
subfamily_PPM1E_pd Subfamily PPM1E 412-496 3.4e-08 26.0 In-house 181-256 (265) alignment 
Range on Protein: 412-496
Range on HMM: 181-256/265.0
SIKPFLSAVPEISVTNLRDmntltDKDVVIVASDGLWDVLSNEDAGLIVRSTLGSTDsadpSRYTQAAQDLVAAARGQQASGNLK
. ||..|. .... ..| .     .....|.|.||||||. .|..  .|.. | ..     . ....|. ||.||. ...| |. 
klkpyvsgeadvaeveldg.....seeylilacDGlwDvvneeevvklveefladga....edlsevakllveaakeagssDnit
subfamily_PPM1D_pd Subfamily PPM1D 169-315 8.9e-08 24.6 In-house 32-155 (309) alignment 
Range on Protein: 169-315
Range on HMM: 32-155/309.0
RADGALFSLFDGHAGSAVAVVASKCLHEHVKSRLCEvldtilH------MdrhenlnfgkhrsessysmsemsredenrirsehlvKGALETAFLDMDEQ
. . | ...|||| |   |  |.. | . .| .                .                                      |.. |||.. |.
elevafvavfDGHGGkeAakfarehlwsvikkqkkf......lssepedv....................................leAireaflathea

IAQDKQVWRL-------PGGCAVISVLVFLGKLYIANAGDCRAILVTSDG------SRALSKDLTP
. . .. |           |  .  |..   |||.|. || ...| ...       .. | ||  |
mkkkleeWpktksgllstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkP
subfamily_PDP_pd Subfamily PDP 414-480 1e-07 24.4 In-house 267-328 (398) alignment 
Range on Protein: 414-480
Range on HMM: 267-328/398.0
KPFLSAVPEISVTNLRDmntlTDKdVVIVASDGLWDVLSNEDAGLIVRSTLGSTDSADPSRYTQAAQ
 |.|.| ||.   .||     .||  ...|.|||||.||||..  .|   | ......| . ..|  
PPYltaePevtshklre....ndk.FLvlatDGLwdllsneevvslVgehlakkkekepvkveeakl
subfamily_PP2D1_pd Subfamily PP2D1 163-282 1.3e-07 23.7 In-house 24-150 (492) alignment 
Range on Protein: 163-282
Range on HMM: 24-150/492.0
SSMFAPRADGALFSLFDGHAGSAVAVVASKCLHEHVKSRLCEV---LDTILHMDRHENLNFGKHRSESS---YSMSEMsrEDENRIRSEH-LVKGALETA
 . |.. .. . |...||. |.. | .|.| ||| . ..| .|   ..    ... .| .. ... | .    |....    |. ...|.  || |.. .
qdyfgndvnscFfgiyDGynGataAeiaakelhevlleelekvdervslttavnlidnndltdyelerasrsdsirai..lkeesvkpefekvkkAfrks

FLDMDEQIAQD--KQVWRLPGGCAVISVL
.|..|. .      .      ||. ...|
ylrldrlLsygieeesrvrWsGCsAltll
subfamily_PPM1E_pd Subfamily PPM1E 229-321 1.3e-07 24.1 In-house 57-151 (265) alignment 
Range on Protein: 229-321
Range on HMM: 57-151/265.0
YSMSEMSREDENRIRSEHLVKGALETAFLDMDEQIAQDKQVWRLPGGCAVISVLVFLGKLYIANAGDCRAILVTSDGSRALSKDLTPASE--RKR
|. ... .   .. . ..  . ||. ||  .||.. |  .  .| .|.  ..||.   .||.|  || .|.||     . | |   |  |  .||
yaaahlhellvrqeklkedpaealkeafkltDerflqkaereklksGstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkR
subfamily_PPM1D_pd Subfamily PPM1D 415-495 2e-07 23.4 In-house 220-295 (309) alignment 
Range on Protein: 415-495
Range on HMM: 220-295/309.0
PFLSAVPEISVTNLrdmnTLTDKDVVIVASDGLWDVLSNEDAGLIVRSTLGSTDSADPSRyTQAAQDLVAAARGQQASGNL
   | .|...|..|    .  .....|.||||||.||. |||  .|...   .   . .  .. |. ||  | .. .| .|
fvvsPePdvkvrtl....dpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqs.rsvakalvkealqrwrskkl
subfamily_ILKAP_pd Subfamily ILKAP 244-323 3.4e-07 22.7 In-house 81-170 (293) alignment 
Range on Protein: 244-323
Range on HMM: 81-170/293.0
SEHLVKGALETAFLDMDEQI----AQDKQVWRlpGGCAVISVLVFLGKLYIANAGDCRAILVTSDGSRA------LSKDLTPAS--ERKRLQ
 |. .| .|  .|   ||.     ...| ||.   |.....|||    ||.|| || .|.||  . .        |.|| ||..  ||||.|
kekeikkclvdsfkktdeefLklaskakPvWk..dGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriq
PP2C_SIG_SM00331 433-516 3.5e-07 23.0 In-house 146-215 (217) alignment 
Range on Protein: 433-516
Range on HMM: 146-215/217.0
TLTDKDVVIVASDGLWDVL-----SNEDAGLIVRSTLgSTDSADPSRytQAAQDLVAAARGQQAsgnlkrwvmntgghasYDDITVFVI
.|  .|... ..|||...       .|.  .|..... .. ... ..  .  ..|...|.|..                  ||||| |.
elekgdllllytDGltearsekgfaeerleeiledlv.dseaqelaq..kiveellelakgsng................eDdiTvvvv
subfamily_KAPP-like_pd Subfamily KAPP-like 170-315 7.5e-07 21.4 In-house 32-145 (266) alignment 
Range on Protein: 170-315
Range on HMM: 32-145/266.0
ADGALFSLFDGHAGSAVAVVASKCLHEHVKSRLCEvldtilhmdrhenlnfgkhrsessysmsemsREDENRIRSEHLVKGALETAFLDMDEQIAQdkqv
.. |||..||||||  .|. |.| . . ..  | .                                ....   . .  .. || || ..|... .    
snialfavfdGhaGkGaadaakklfpkelekllks...............................tkqddGGdniydqskllenafkevdaklkd....

WRLPGGCAVISVLVFLGK---LYIANAGDCRAILVTSDGSRALSKDLTP
.   |  | ....   |.   | .|| ||  |.|   . |  ||||   
feyeGatatlalvwsdGqqrylqvanvGdssaflsrGneslelskdhka
subfamily_PPTC7_pd Subfamily PPTC7 433-516 1.1e-06 21.2 In-house 163-249 (252) alignment 
Range on Protein: 433-516
Range on HMM: 163-249/252.0
TLTDKDVVIVASDGLWDVLSNEDagliVRSTLGSTDSADPSRYTQAAQDLVAAARGQQASGNLKRW---------VMNTGGHasYDDITVFVI
.. ..|....|.|||.| |....    . ..|   .....|.  ..|..|...||    . . .           .  .||    ||||| |.
avkkgDiivlatDGlfDNllede....ileilkelkeseksslqslakklaekarelsldpeyespfaqkakkngleasGGK..pDDitvvva
subfamily_PPM1G_pd Subfamily PPM1G 393-464 2.8e-06 19.6 In-house 363-429 (473) alignment 
Range on Protein: 393-464
Range on HMM: 363-429/473.0
IGVSRGFGDHHLLTVDERLSIKPFLSAVPEISVTNLRDmntltDKDVVIVASDGLWDVLSNEDAGLIVRSTL
. .|| .|||   .  |       .||.|.| |. | .     . . ...|.||.|.|.. ..    ||. |
LnlsRAlGDhaYkkneeLplkeqmisAlPDikvltlte.....edeFlvlAcDGiWnvmesqevvdfvrakl
subfamily_PPM1L_pd Subfamily PPM1L 394-467 4e-06 19.3 In-house 177-239 (269) alignment 
Range on Protein: 394-467
Range on HMM: 177-239/269.0
GVSRGFGDHHLltVDerlsiKPFLSAVPEISVTNLRDMNtltdKDVVIVASDGLWDVLSNEDAGLIVRSTLGST
 .|| .||. |   |     | .. | |.|   .| |..     . .|.||||||| .|||.|   ..  |.  
atsralGdypl..kd.....knlviadpdiltfdlddhk....peflilasdGlwdtfsneeavrfikerlkep
subfamily_PPM1G_pd Subfamily PPM1G 231-319 4.7e-06 18.8 In-house 251-341 (473) alignment 
Range on Protein: 231-319
Range on HMM: 251-341/473.0
MSEMSREDENRIRSEHLVKGALE--TAFLDMDEQIAQDKQVWRLPGGCAVISVLVFLGKLYIANAGDCRAILVTSDGSRALSKDLTPASER
 .| ..|.|. .. |.  . . .      ..  .  ..|..     |.  . .|.   ||..|||||.|..|  .     || |  |  | 
deeeaeeeeeeedeedeeeeeedgegeeakeeldgseekeepGedsGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDev
subfamily_PPM1K_pd Subfamily PPM1K 241-347 6.9e-06 18.4 In-house 60-171 (263) alignment 
Range on Protein: 241-347
Range on HMM: 60-171/263.0
RIRSEHLVKGALETAFLDMDEQIAQDKQVW------RLPGGCAVISVLVFLGKLYIANAGDCRAILVTSDGSRALSKDLTPASERkRLQELAYRNPELIG
    |. ..  |  ||...|... .  .           |  | .|.|    .| .|. || ||||     .. |..| .|  |    . .   .  .  
llekekdleivlknafeeldkklkrylefsvaeaellssGttatvsllrdGtelvlaslGdsrailcrnGkakkltrdhdPelee.ekerikaagGsvew

NSFSRLEYSKRLT
||  ..    ||.
nslgkplvngrla