Gene C47A4.3 in Caenorhabditis elegans

Synonym: CELE_C47A4.3, CELE_C47A4.3

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily CelePPP-sf4
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP038_AA protein Get Run
CeleP038_AA_3-300 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 5-301 1.6e-211 693.6 In-house 1-297 (297) alignment 
Range on Protein: 5-301
Range on HMM: 1-297/297.0
VVDSIIIDVLSASTHEKPLCKVITEERVLKLLDLALGVFKAQKPMVEVNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLL
|||||||||||||||||.|.||||||||||||||||.||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||
vvdsiiidvlsasthekllskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivll

LAYKVKFPCNFFLLRGNHECEFVNKTYGFYEECQKRYQSVRMYAAFQDVFNWLPLTGLIATKILCMHGGLSPLMTKEFTLDTLRKIERPTEGKEGLVADL
||||||||.|.||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||.|||||.|||||
laykvkfpgnlfllrgnhecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierstegkerlvadl

LWADPISGLSGFMNNQRGAGCGFGRDSVLNLCSEFQLDLVCRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEILRPTTG
|||||||||||||.||||||||||||.||.|||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|
lwadpisglsgfmenqrgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilrptsg
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 5-300 1.1e-157 516.6 In-house 2-295 (298) alignment 
Range on Protein: 5-300
Range on HMM: 2-295/298.0
VVDSIIIDVLSASTHEKPLCKVITEERVLKLLDLALGVFKAQKPMVEVNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLL
.||...|.|||.|..|| |.|||.||.| ||..||  .||.|| .|||.||||||||||||..||||||...|.||.||||||||||||||...|.||||
evdellievlsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivll

LAYKVKFPCNFFLLRGNHECEFVNKTYGFYEECQKRYQSVRMYAAFQDVFNWLPLTGLIATKILCMHGGLSPLMTkefTLDTLRKIERPTEGKE-GLVAD
||||||.|.||||||||||||..|..|||||||..||.|.|.||.||||||.||||.||...|||||||||. ..   .||.||...||...||  |..|
laykvkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklk...sldqlrelkrpfdskeeslaid

LLWADPISGLSGFMNNQRGAGCGFGRDSVLNLCSEFQLDLVCRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEILRPTT
|||||| . ..|...|.||... ||.|.| .|......|||.||||||||||||||..|||||||||||||||||.||.|..||||..|||.|.|..
llwadpenavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpek
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 6-301 4.7e-123 403.2 In-house 3-296 (299) alignment 
Range on Protein: 6-301
Range on HMM: 3-296/299.0
VDSIIIDVLSASTHEKPLCKVITEERVLKLLDLALGVFKAQKPMVEVNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLLL
|| ..  .|.    || | | . |. . .| ..|  ||  |  ..||.|||.||||||||. ||||.|.. |.|| .|.|||||||||||  .|.|.|||
vdellskllnvgmsekrltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlll

AYKVKFPCNFFLLRGNHECEFVNKTYGFYEECQKRYQSVRMYAAFQDVFNWLPLTGLIATKILCMHGGLSPLMTkefTLDTLRKIERPTEGKE-GLVADL
..|.|.| .||.|||||||  .|. |||||||.|||.| |....||| |...||||||...|||||||||| ..   |||.||.. || .  .  |  ||
cfkikyperffmlrgnhecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklq...tldqlrdltrpqdppnpslgidl

LWADPISGLSGFMNNQRGAGCGFGRDSVLNLCSEFQLDLVCRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEILRPTTG
|||||   . ....| ||    ||.| | . .| ...|||.|||||||||||||| .||||||||||||||||| || |  ||.| |.| .|.||. 
lwadpdqsvkdwlanvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpk
subfamily_PPP1C_pd Subfamily PPP1C 26-300 1e-115 378.8 In-house 9-280 (282) alignment 
Range on Protein: 26-300
Range on HMM: 9-280/282.0
VITEERVLKLLDLALGVFKAQKPMVEVNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPCNFFLLRGNHECE
 ..|. . .||. |  ....|  ..|..||.|..||||||. ||||||...| ||..||||||||||||..|.||||||||||.|.| |.||||||||. 
klkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesa

FVNKTYGFYEECQKRYQSVrMYAAFQDVFNWLPLTGLIATKILCMHGGLSPLMTKeftLDTLRKIERPTEG-KEGLVADLLWADPISGLSGFMNNQRGAG
 .|..||||.||..||..  .. .|.||||.|||. |.. ||||.|||||| ...   |. .|||.||.|  ..||..||||.|| .   |. .|.||  
sinriyGfydeckrrysik.lWktftdvfnclPlaalvdekilcvhGGlspelks...leqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvs

CGFGRDSVLNLCSEFQLDLVCRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEILRPTT
  ||.| | .......|||..||||||.||||||| |.|||.||||.|||.|||..| .| ||.| .||.||.|..
ftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpak
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 24-299 4.7e-113 370.0 In-house 3-275 (280) alignment 
Range on Protein: 24-299
Range on HMM: 3-275/280.0
CKVITEERVLKLLDLALGVFKAQKPMVEVNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPCNFFLLRGNHE
 ..| |  . ....    ...||. ||||.||..||||.|||..|||||| | ..||  |||||||||||||. .| |.|||||||..| ||..||||||
lacikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhe

CEFVNKTYGFYEECQKRYqSVRMYAAFQDVFNWLPLTGLIATKILCMHGGLSPLMTkefTLDTLRKIERPTEGK-EGLVADLLWADPISGLSGFMNNQRG
.  .|..|||..|...|| |  .|. ||.... |||. |.. .|||||||||. .    .|| |... || . . | |  ||||||| . ..|. .|.||
visinrkygfkdevkrry.slalynefqelldslplvalvsgrilcmhgglsqklv...slddlaelrrpfdsedeclamdllwadpenkvtgwaensrg

AGCGFGRDSVLNLCSEFQLDLVCRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEILRPT
.   || . | .|.  ...||..| ||||||||||||..||||.||||.|.|.||| || .  ||.|. |||.|.| 
vsvifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpa
PP2Ac_SM00156 28-299 6e-107 349.7 In-house 2-270 (271) alignment 
Range on Protein: 28-299
Range on HMM: 2-270/271.0
TEERVLKLLDLALGVFKAQKPMVEVNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPCNFFLLRGNHECEFV
..| ||.||. .  ..|..|..|||.||. |.||||||. |||||....| ||. .|.||||||||| .|||.|.||.|.|...| ...|||||||.. |
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

NKTYGFYEECQKRYqSVRMYAAFQDVFNWLPLTGLIATKILCMHGGLSPlmtKEFTLDTLRKIERPTE-GKEGLVADLLWADPISGLSGFMNNQRGAGCG
||.|||.||.. .| . ..|. |...|..|||. |. .|||||||||||   .. .||..||..|. |  .|||..||||.|| .  .|| ...||... 
nkiygfeeevkrky.gkeiyekfeeafsllPlaalvdskilcmhGGlsp...eleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvv

FGRDSVLNLCSEFQLDLVCRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEILRPT
||.| | .......|.|..|||.||..|||||| .|||||||||.||..|.| ||... ...|..|.| |...
FgedavkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 26-299 8.2e-106 346.6 In-house 2-274 (284) alignment 
Range on Protein: 26-299
Range on HMM: 2-274/284.0
VITEERVLKLLDLALGVFKAQKPMVEVNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPCNFFLLRGNHECE
.|. | |  ||  |. .|. |  ..|||.||..|||||||| |||||| . |.|  |||||||||||||.  .|||.||.|||| ||  ||.||||||| 
lippedvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecs

FVNKTYGFYEECQKRYQSVRMYAAFQDVFNWLPLTGLIATKILCMHGGLSPLMTKeftLDTLRKIERPTEGKE--GLVADLLWADPISGLSGFMNNQRGA
..|| ||||||||.||.   .| .|. ||  .||| |.  .|||||||.| .. .   .  || |.|| .  |   |  |.||.||     |.  | || 
linkiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqn...vsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgv

GCGFGRDSVLNLCSEFQLDLVCRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEILRPT
   || |.. .|   .|.||| |||||||||||||| |.|||||||| |||||||.|| |  ...| ||| .||| 
syvfgsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrpr
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 26-298 2.9e-101 331.6 In-house 7-282 (284) alignment 
Range on Protein: 26-298
Range on HMM: 7-282/284.0
VITEERVLKLLDLALGVFKAQKPMVEVNAPIKVCGDIHGQFPDLLRLFHRGGWP------PTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPCNFFLLR
...|. ...|   |  .|  .|  .|..||.|..||||||| ||| |..  |||         .||||||||||| |||| |.||.|||...| . ||||
llkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllr

GNHECEFVNKTYGFYEECQKRYqSVRMYAAFQDVFNWLPLTGLIATKILCMHGGLSplmTKEFTLDTLRKIERPTEGKE-GLVADLLWADPISGLSGFMN
||||   ||. ||||.||.||| |...| |||  || .||. ... ||.|||||.|    . . |. | |.|||..  . |..||| |||| . ..|. .
gnhesrpvnmqygfyleckkry.sealyeafqlafnamplcavvskkiicmhggis...edlldlkqldklerpidipdigviadltwadpeaevegyke

NQRGAGCGFGRDSVLNLCSEFQLDLVCRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEILRP
 .||||  || ..| ... .|.|||| ||||||.||||||| |||||||||| ||||.|| || .. ||.| .|| .|.|
sprgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkp
0045823 Metallo-dependent phosphatases 11-300 6e-100 328.1 In-house 27-325 (473) alignment 
Range on Protein: 11-300
Range on HMM: 27-325/473.0
IDVLSASTHEKPLCKVITEERVLKLLDLALGVFKAQKPMVEVNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLLLAYKVK
. .|.. ..    .....|| .||||| |  ..| .....|....| |.||||||. |||||... |.||  ...||||.|||| .|.|.. ||||.|.|
lldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkik

FPCNFFLLRGNHECEFVNKTYGFYEECQKRYqSVRMYAAFQDVFNWLPLTGLIATKILCMHGGLSPLMtkeFTLDTLRKIERPTEG-KEGLVADLLWADP
.| |.||||||||. ..|  |||..|. ..| ....| .|......|||. .|  |||..|||||| .    .|| .|.|||| |  ..||. ||||.||
ypgnvfllrGNHElrllnglygfgdetleky.gedlyeeflewlrslPlaaviggkilfvHGGlspdl...plldqireierpleipddgllldllwsdP

iSGLSG--------FMNNQRGAGCGFGRDSVLNLCSEFQLDLVCRAHQVVQDGYEFFAGRK------LVTIFSAPHYCGQFDNCAAFMSCDEKLqCSFEI
    .|        |.|..||||. ||.| | .......|||..|.|..|..|||.. ..|      ..|.||||.|||...|.||..  ||.| .|| .
.weddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiq

LRPTT
..|. 
fdpsp
subfamily_PPZ_pd Subfamily PPZ 7-299 2.2e-97 319.2 In-house 4-294 (300) alignment 
Range on Protein: 7-299
Range on HMM: 4-294/300.0
DSIIIDVLSASTHEKPLCKV-ITEERVLKLLDLALGVFKAQKPMVEVNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLLL
| ||  .| |    |   .| . .. .|..   |  .| ||  ..|.. ..|. ||.|||. |||||| . |.||.|||||||||||||. |.|||.|||
deiiqklldagyaakrtknvclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillll

AYKVKFPCNFFLLRGNHECEFVNKTYGFYEECQKRYqSVRMYAAFQDVFNWLPLTGLIATKILCMHGGLSPLMTkefTLDTLRKIERPTEGK-EGLVADL
.||.|.| |||||||||||  | . ||||.||..|   .... .| | || |||. ..| ||.|.||||||..    ..| .|.. |||.    ||. ||
cykikypenffllrgnhecanvtrvygfydeckrrc.nikiwktfvdtfntlplaaivagkifcvhgglspvln...smdeirhvvrptdvpdfglindl

LWADPISGLSGFMNNQRGAGCGFGRDSVLNLCSEFQLDLVCRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEILRPT
||.||      . .|.||    . . .. ..  .| .||||||| ||.||||||  | |||.|||| |||.|||  | ||  | | ||||.| | 
lwsdptdssnewednergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldpl
PPP_3 27-296 3.9e-97 317.5 In-house 2-269 (271) alignment 
Range on Protein: 27-296
Range on HMM: 2-269/271.0
ITEERVLKLLDLALGVFKAQKPMVEVNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPCNFFLLRGNHECEF
..|. . .|.. .  ... .. .||..||..||||||||. |||.||. || .|. .||||||||||| .|.|...||||.|.|.| ...|||||||.. 
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

VNKTYGFYEECQKRYQSVRMYAAFQDVFNWLPLTGLIATKILCMHGGLSPLMTkefTLDTLRKIERPTE-GKEGLVADLLWADPISGLSGFMNNQRGAGC
.||.|||..|..|.... ..| ..|.||..|||. ||  |.|..|||||| ..   .||...|.||..|  .||.. |||. .. .  .|. |..||||.
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsik...sldqikklerkievpeegklldlllssdpekeeglenskrGagl

GFGRDSVLNLCSEFQLDLVCRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEIL
 || | . ..... .|.|..|||.....|||... .|.||.||||.||....| .|... .|.|...|..|
lFgpdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkql
0049330 Metallo-dependent phosphatases 4-300 1.5e-95 312.8 In-house 7-300 (309) alignment 
Range on Protein: 4-300
Range on HMM: 7-300/309.0
NVVDSIIIDVLSASTHEKPLCKVITEERVLKLLDLALGVFKAQKPMVEVNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVL
 .....|...|.. ..    .|...|| .|.||. |  ..| .....|....| |.||||||. |||||... |.||  ...||||.|||| .|.|.. |
llllelilslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlll

LLAYKVKFPCNFFLLRGNHECEFVNKTYGFYEECQKRYQsVRMYAAFQDVFNWLPLTGLIATKILCMHGGLSPLMtkeFTLDTLRKIERPTEGK-EGLVA
|||.|...| |.||||||||. ..|  |||..|.. .|  .... .|.|....|||. .|  ||||.|||||| .    .|| .|..|||.|   .||..
llalkllypdnvfllrGNHElrllnglygfgdetlrkyg.aelweefldwlrslplaaviggkilcvHgGlspdl...llldqirelerpleipldgllc

DLLWADPISGLSGFMNNQRGAGCGFGRDSVLNLCSEFQLDLVCRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEILRPTT
||||.||.   .|| .|.||.|. || . | ...  ..|||..|.|..|..||..|...||.|.||||.|||...|..|..  ||.| .|| ...|..
dllwsdplpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvp
PPP_1 29-284 7.6e-93 303.6 In-house 3-263 (264) alignment 
Range on Protein: 29-284
Range on HMM: 3-263/264.0
EERVLKLLDLALGVFKAQKPMVEVNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPCNFFLLRGNHECEFVN
|| . .|.. .  ... .. ..||...|.||||||||| |||.||. || .|. |||||||||||| .|.|...||||.|.|.| ..||||||||.. |.
eeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvt

KTYGFYEECQKRYQSVRMYAAFQDVFNWLPLTGLIATKILCMHGGLSPLMTKEFTLDTL-RKIERPTEGKEGLV----ADLLWADPISGLSGFMNNQRGA
|.|||..|..|...| ..| ...|||..|||. ||  |||..|||||| .. .    .. ||.| |.|||        .| |. |. .  ... |..|||
kvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRGa

GCGFGRDSVLNLCSEFQLDLVCRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMS
|. ||.| . .......|.|..|||.|...||||.. ||.||||||. |. ...| .|...
gylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 23-299 7.2e-91 297.3 In-house 3-277 (281) alignment 
Range on Protein: 23-299
Range on HMM: 3-277/281.0
LCKV-ITEERVLKLLDLALGVFKAQKPMVEVNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPCNFFLLRGN
..|| .|.| . ...  .  .|  .| .||...||.| ||.|.|| || |||.  | .|   ..|||||||||  |.|...||...|.... . .|||||
ihkvqytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgn

HECEFVNKTYGFYEECQKRYqSVRMYAAFQDVFNWLPLTGLIATKILCMHGGLSPLMTkefTLDTLRKIERPTEG-KEGLVADLLWADPISGLSGFMNNQ
||   ||| ||||.||. .|  . ..| ||  || ||...|||...||||||||| .|   .||.||.. .| .    ||| ||||||| .   ....  
heiasvnkiygfyvecvtky.GeelwalfqrcfnrlpisaliakrvlcmhGGlsPelt...aldelrnrpkpirnldrGlviDllwadpdnkveewkass

RGAGCGFGRDSVLNLCSEFQLDLVCRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEILRPT
||..  ||.. | . | .....|. ||||||||||| ..||||.|.||.| || .. |.|| .  ||.|. |.  | |.
rGssftfGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpa
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 27-300 1.1e-90 296.5 In-house 10-283 (287) alignment 
Range on Protein: 27-300
Range on HMM: 10-283/287.0
ITEERVLKLLDLALGVFKAQKPMVEVNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPCNFFLLRGNHECEF
.... .|..|. .  ...  . ..||.|||...||||||. ||||.|.  | .|  .|||||||||||  |.| ..||...|...| .  |||||||.. 
fsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkk

VNKTYGFYEECQKRYQsVRMYAAFQDVFNWLPLTGLIATKILCMHGGLSPLMTKEFTLDTLRKIERPTEGKEGLVADLLWADPISGLSGF-MNNQRGAGC
.||.|||.|| ....|  |.|  |.|||. |||   .. .|||||||.|| .     | .|.| . | . .|||. |||||||     .| .| .|.   
inklyGfkeelkrkrq.erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisv

GFGRDSVLNLCSEFQLDLVCRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEILRPTT
 ||. .| .|. ....||. |||.|...||.|.. ..|||.||||.|.|.  |..| .  .. |. ||  |.|  
vfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkped
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 82-300 1.2e-90 296.9 In-house 101-316 (317) alignment 
Range on Protein: 82-300
Range on HMM: 101-316/317.0
ANYLFLGDYVDRGRFSIETIVLLLAYKVKFPCNFFLLRGNHECEFVNKTYGFYEECQKRYqSVRMYAAFQDVFNWLPLTGLIATKILCMHGGLSPLMtke
 .||||||||||| |||| ..||.|.|...| . ||||||||   ||. ||||.|..||| |...| ||| .|| |||. ... ||||||||.|  .   
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkry.saalyeafqlafnvlplcavvnkkilcmhGGiseel...

FTLDTLRKIERPTEGKE-GLVADLLWADPISGLSGFMNNQRGAGCGFGRDSVLNLCSEFQLDLVCRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCA
. |. | |..||..  . |..||| |||| .  .|. . .||||  || ..| ... ...|||| ||||||.|||||||.|||||||||| ||||.|| |
ldlkqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldnia

AFMSCDEKLQCSFEILRPTT
| .| |.||..|...||| .
avlsvdkklkisinvlrpes
0053225 Metallo-dependent phosphatases 9-298 8.1e-89 290.8 In-house 4-290 (293) alignment 
Range on Protein: 9-298
Range on HMM: 4-290/293.0
IIIDVLSASTHEKPLCKVITEERVLKLLDLALGVFKAQKPMVEVNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLLLAYK
.|. .|.. ..   |.|...|| .|.||..|  ..| .. ..|....| |.|||||.. |||.|... |.||. ...||||.|||| .|.|.. ||||.|
lilllldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalk

VKFPCNFFLLRGNHECEFVNKTYGFYEECQKRYQSVRMYAAFQDVFNWLPLTGLIATKILCMHGGLSPLMTkefTLDTLRKIERPTEGK-EGLVADLLWA
...| |..|||||||. ..|  |||..|.  .| . ... ...|....|||. ||  |||..|||||| ..   .|| .|.|.||...  |||..|||| 
llypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdls...lldqireinrplriplegllldllws

DPIsGLSGFMNNQRGAGCGFGRDSVLNLCSEFQLDLVCRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEILRP
||    ||.. ..||.|. || . ||...  ..|||..|.||||.|||... ..||||.||||.|.|...|..|..  ||.| ..| ...|
dpd.lwsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfap
subfamily_PPP4C_pd Subfamily PPP4C 23-297 7.5e-87 284.2 In-house 12-283 (288) alignment 
Range on Protein: 23-297
Range on HMM: 12-283/288.0
LCKVITEERVLKLLDLALGVFKAQKPMVEVNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPCNFFLLRGNH
 |..|.|| | .|   |  ..  .  . .|..|. ||||||||| |||.||. ||  |  |||||||.|||| .|.||..||||.||..| .  |.||||
rcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnh

ECEFVNKTYGFYEECQKRYQSVRMYAAFQDVFNWLPLTGLIATKILCMHGGLSPLMTkefTLDTLRKIERPTE-GKEGLVADLLWADPISGlSGFMNNQR
|.  . ..||||.|| ..| |....    .||..|.|. .|  ||.|.|||||| ..   ||| .| |.| .|  .|| ..||||.||    .|.    |
esrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsis...tldeirsidrkqevphegplcdllwsdpeda.egwavspr

GAGCGFGRDSVLNLCSEFQLDLVCRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEILR
|||  || | | ..... ...|.|||||.|..|| .   .|..|..||| || .  | || .  ||.|.  |.|. 
gagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkife
subfamily_PPP2C_pd Subfamily PPP2C 23-299 4.4e-86 281.7 In-house 13-286 (290) alignment 
Range on Protein: 23-299
Range on HMM: 13-286/290.0
LCKVITEERVLKLLDLALGVFKAQKPMVEVNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPCNFFLLRGNH
 || ..|..| .| . |  ... .. . ||..|. ||||.|||| ||| ||. ||  | .|||||||||||| .|.||. || | ||...    .|||||
eckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnh

ECEFVNKTYGFYEECQKRYQSVRMYAAFQDVFNWLPLTGLIATKILCMHGGLSPLMTkefTLDTLRKIERPTE-GKEGLVADLLWADPIsGLSGFMNNQR
|   . . ||||.|| ..| .  ..  | |.|..||||.|.  .|.|.|||||| ..   ||| .|...|  |  .|| ..||||.||    .|.   .|
esrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsid...tldkiraldrlqevphegplcdllwsdpd.drggwgispr

GAGCGFGRDSVLNLCSEFQLDLVCRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEILRPT
|||  ||.|   ..  . .| |. ||||.| .||..   |..||||||| || .  | || .  |.||. ||    |.
gagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpa
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 23-298 4.8e-82 268.6 In-house 2-274 (280) alignment 
Range on Protein: 23-298
Range on HMM: 2-274/280.0
LCKVITEERVLKLLDLALGVFKAQKPMVEVNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPCNFFLLRGNH
.|.|.|   .. .. .   .|  .  ..| .||||| |||| |. |. |||   |  |  . .|||||||||   || ..||.. |...    .||||||
icnvmtgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnh

ECEFVNKTYGFYEECQKRYqSVRMYAAFQDVFNWLPLTGLIATKILCMHGGLSPLMtkeFTLDTLRKIERPTEGK-EGLVADLLWADPISGLSGFMNNQR
|   ||| |||| ||| .|  | ..  || .|| .|..|||. ..||||||||| .     |||.|.| || |    ||. ||||.||     |.. . |
etpsvnkiygfyvecqyky.gvglwwdfqscfnrmpmsgliskrvlcmhgglspel...inldtirniprpcepldrgllidllwsdptnkgegwfhsir

GAGCGFGRDSVLNLCSEFQLDLVCRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEILRP
|    ||.  | . |  ...||. |||||||||||..|||.|.|.|| | || || |.|| .  . .|| ||. | |
gisymfgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlip
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 27-299 1.7e-80 263.1 In-house 16-289 (290) alignment 
Range on Protein: 27-299
Range on HMM: 16-289/290.0
ITEERVLKLLDLALGVFKAQKPMVEVNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPCNFFLLRGNHECEF
.... .|..|. .  ...    ..||.||| . ||||||. .||| |.  | ||  ..||||||||||  |.|  .||. ||.... .  |||||||.  
fsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrk

VNKTYGFYEECQKRyQSVRMYAAFQDVFNWLPLTGLIATKILCMHGGLSPLMTKEFTLDTLRKIERPTEGKEGLVADLLWADPIS-GL-SGFMNNQRGAG
||. |||.||  .. .. |..  .||||. |.|   .. ||||||||.|. .    .| .|.| . |.. .|||. |||||||      .  .| ||.  
vnrlygfkeelark.rgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqrais

CGFGRDSVLNLCSEFQLDLVCRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEILRPT
  ||.... .|. .. |.|. |||.| ..|..|   .||||.||||.|.|.  |. | .   | |. |. .|.| 
vvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkpr
subfamily_PPP6C_pd Subfamily PPP6C 24-296 3.8e-79 258.8 In-house 12-281 (290) alignment 
Range on Protein: 24-296
Range on HMM: 12-281/290.0
CKVITEERVLKLLDLALGVFKAQKPMVEVNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPCNFFLLRGNHE
|| ..|. . || || | ..  .  .. |..|. ||||||||| ||. ||. ||  | ..|.||||.|||| .|.||. .||. |.|.| .  |||||||
ckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhe

CEFVNKTYGFYEECQKRYQSVRMYAAFQDVFNWLPLTGLIATKILCMHGGLSPLMTkefTLDTLRKIERPTE-GKEGLVADLLWADPiSGLSGFMNNQRG
.  . . ||||.||...| ..  .  . .||. |... .|  ..||.|||||| ..   ||| .| ||| .|  ..| ..||.|.||   .. ..  .||
srqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvk...tldqirvieraqeiphkgafcdlvwsdp.edvetwavsprg

AGCGFGRDSVLNLCSEFQLDLVCRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEIL
||  ||.  . ....  .|.|.|||||.|..|....   ||||..||| || .  | |. .. ... . .....
agylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklf
subfamily_PPP5C_pd Subfamily PPP5C 25-290 6.1e-78 255.1 In-house 32-300 (322) alignment 
Range on Protein: 25-290
Range on HMM: 32-300/322.0
KVITEERVLKLLDLALGVFKAQKPMVEVNAP----IKVCGDIHGQFPDLLRLFHRGGWPPT-ANYLFLGDYVDRGRFSIETIVLLLAYKVKFPCNFFLLR
| . .  .||.|  |  ..|..  .||.. .    . ||||||||| ||| .|.  | | .   ||| ||.|||| ||.|.|..||..|. .| .||| |
kklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsr

GNHECEFVNKTYGFYEECQKRYQSvRMYAAFQDVFNWLPLTGLIATKILCMHGGLspLMTKEFTLDTLRKIERPT-EGKEGLVADLLWADPISgLSGFMN
|||| . .|| ||| .|....|.. ...  |..|||||||. .|  |.| .||||    ... ||| ||||.| . . .|||. .|||.|| .  .| ..
GnhesdnmnklyGfegevkakyte.kvadlftevfnwlPlahvinekvlvvhGGl..fsedgvtlddlrkidrnaqppeegllvellwsdpqe.anGrsp

NQRGAGCGFGRDSVLNLCSEFQLDLVCRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSC-DEKLQ
 .|| |. || |   ... | .|.|. |.|.| ..|||.    ||.|.|||| || | .| .||..  ...|.
skrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlk
subfamily_PPP3C_pd Subfamily PPP3C 27-287 1.3e-74 244.6 In-house 41-311 (452) alignment 
Range on Protein: 27-287
Range on HMM: 41-311/452.0
ITEERVLKLLDLALGVFKAQKPMVEVNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPCNFFLLRGNHECEF
..|| .||... |  ..| .| ..||.||| |.||||||| |||.||. || | ...||||||||||| ||||... |.| |...| ..|||||||||  
leeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrh

VNKTYGFYEECQKRYqSVRMYAAFQDVFNWLPLTGLIATKILCMHGGLSPLMTkefTLDTLRKIERPTEG-KEGLVADLLWADPISGLSGFM-------N
. . . | |||...| | ..| |. . |. |||. |.  . ||.|||||| ..   .|| ..|..|  |  . |.. ||||.||.   . ..       |
lteyftfkeeckiky.seevydacmesfdslPlaallnqqflcvhGGlspeik...slddikkldrfkeppasGplcdllWsdPledygeekteekfvpn

NQRGAGCGFGRDSVLNLCSEFQLDLVCRAHQVVQDGYEFFAG------RKLVTIFSAPHYCGQFDNCAAFMSCDE
. ||  . ..  .| ..  . .|  . |||.. ..||. .          |.|.|||| |.. ..| || .  ..
svrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyen
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 29-293 2.1e-73 240.2 In-house 22-286 (307) alignment 
Range on Protein: 29-293
Range on HMM: 22-286/307.0
EERVLKLLDLALGVFKAQKPMVEVNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPCNFFLLRGNHECEFVN
 | . ...  |  .| ..| .|... |  | ||.|||| ||. .|   | || . |.| ||||||| .|.|.|.||..||. .| |  |||||||   ||
keefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvn

KTYGFYEECQKRYQS--VRMYAAFQDVFNWLPLTGLIATKILCMHGGLSPLMTkefTLDTLRKIERPTE-GKEGLVADLLWADPISGLSGFMNNQRGAGC
| |||||||          ..| || .|| ||.. ||||||||||||||| .|    || ||.  .|      |.| |.|||||   .  .    ||.| 
kkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspalt...cldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgf

GFGRDSVLNLCSEFQLDLVCRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSF
 || . . ..|  . ..|. ||||.. |||  ..||||.|||||| ||  . |. . .  || |    
tfgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiql
PPP_2 56-250 2.1e-70 229.4 In-house 1-197 (198) alignment 
Range on Protein: 56-250
Range on HMM: 1-197/198.0
IKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPCNFFLLRGNHECEFVNKTYGFYEECQKRYQSVRMYAAFQDVFN
..||||.|||. |||.||. |. .|. .|||||||||||..|.|...||||.|...| ...|||||||.. |||.|||..|..|.... ..| ..|.||.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

WLPLTGLIATKILCMHGGLSPLMTkefTLDTLRKIERPTE-GKEGLVADLL----WADPISGLSGFMNNQRGAGCGFGRDSVLNLCSEFQLDLVCRAHQV
.|||. ||  |.|..|||||. ..   .||. .|.||..|  .||.. |||    . || .  ... |..||||. ||.| . .|.....|.|..|||.|
lLplaalidekvlvvHGGlseeik...lldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 49-299 1.3e-69 227.8 In-house 2-256 (263) alignment 
Range on Protein: 49-299
Range on HMM: 2-256/263.0
MVEVNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPCNFFLLRGNHECEFVNKTYGFYEECQKRYQSVRM--
..|..|||..||| |||. ||||.|   |    ..||||||||||| .|.| |.||.. |. .| ...||||||| . .|| |||. | .||.|   .  
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

--YAAFQDVFNWLPLTGLIATKILCMHGGLSPLMTkefTLDTLRKIERPTEGK--EGLVADLLWADPISGLSGFMNNQ-RGAGCGFGRDSVLNLCSEFQL
  |  |..||...||  ... .|||||||.|| .    .|| .| |  | |      | .|||||||     ||  |. |     ||.  | .||  ...
svynhfnqvfsymplcaivskrilcmhggisphlk...slddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldi

DLVCRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEILRPT
||. ||||||. || ||| |.|.|.||| .|  .. | || .  .. |. ||  |.| 
dlivrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkpe
subfamily_PPG1_pd Subfamily PPG1 24-296 9.4e-69 224.9 In-house 11-293 (300) alignment 
Range on Protein: 24-296
Range on HMM: 11-293/300.0
CKVITEERVLKLLDLALGVFKAQKPMVEVNAPIKVCGDIHGQFPDLLRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPCNFFLLRGNHE
.... |  | .| |    ..  .  ..|...|. | ||.|||| |.| .|. ||  | .|||||||||||| .|.|||.||.. |...|    |||||||
aellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhe

CEFVNKTYGFYEECQKRY-QSVRMYAAFQDVFNWLPLTGLIATKILCMHGGLSPLMtkeFTLDTLRKIERPTE-GKEGLVADLLWADPI---------SG
   . ..|||| || ..|    |..  . ..|..| |. .|  .| |.|||||| .    ..| .. ..|  |  .|| .|||||.||            
srqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsv...lsidqikvldrfrevpnegaladllwsdpeennnptldhpd

LSG--FMNNQRGAGCGFGRDSVLNLCSEFQLDLVCRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEIL
 .|  |.. |||||  .|.| |...    ... . ||||....||. .   || |..||| || .  | |. .   ||..  |.. 
regqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvy
PPP_4 56-250 2.8e-68 222.9 In-house 1-196 (197) alignment 
Range on Protein: 56-250
Range on HMM: 1-196/197.0
IKVCGDIHGQFPDL-LRLFHRGGWPP-TANYLFLGDYVDRGRFSIETIVLLLAYKVKFPCNFFLLRGNHECEFVNKTYGFYEECQKRyQSVRMYAAFQDV
. |.||||||. || |.|.. || |. . .|.||||||||| .|.|...||||.|...| ...|||||||.. .|. |||..|.... .. ... ..|||
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.hgkeilkklqdv

FNWLPLTGLIATKILCMHGGLSPLMTKeftLDTLRKIERPTEG--KEGLVADL-LWADPISGLSGFMNNQRGAGCGFGRDSVLNLCSEFQLDLVCRAHQV
|..|||. ||. |.|..|||||. ...   ||....|||..|   .|..  || ||.|| .  .|. |..||||. ||.| . ..... .|.|..|.|..
fdllplaalidekvlvvhgglsdeles...ldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 27-298 9.7e-68 221.5 In-house 6-299 (302) alignment 
Range on Protein: 27-298
Range on HMM: 6-299/302.0
ITEERVLKLLDLALGVFKAQKPMVEVNAPIKVCGDIHGQFPDLLRLFHRGGWP-----------PTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPCNF
 ... .|.|..     .| .| ..|. .|. . |||||||.||.|..                  .  ..|||||||||. ||| | |..|.|| .| |.
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

FLLRGNHECEFVNKTYGFYEECQKRYQ---SVRMYAAFQDVFNWLPLTGLIATKILCMHGGLSPLMTkefTLDTLRKIERPTEG--KEGLVADLLWADPI
 |||||||.. .| .||| || ..|.      ...  |..|| ..||. |.  ||||.|||.|| ..   .|. ..||.|| .   .. |  |||.|||.
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispkle...sledikkikrplkevtedslaqdllfadpl

SGL--------SGF-MNNQRGAGCGFGRDSVLNLCSEFQLDLVCRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEILRP
 .           .  |. ||    |   .| ..|  ..|.|. ||||..  |. ||| .||.|||||| |  . ||  | .  | . . |  .||.
dvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrn
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 27-298 1.9e-67 220.6 In-house 7-300 (302) alignment 
Range on Protein: 27-298
Range on HMM: 7-300/302.0
ITEERVLKLLDLALGVFKAQKPMVEVNAPIKVCGDIHGQFPDLLRLFHRGGWP-----------PTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPCNF
 ... .|.|..     .| .| ..|. .|. . |||||||.||.|..                  .  ..|||||||||. ||| | |..|.|| .| |.
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

FLLRGNHECEFVNKTYGFYEECQKRYQ---SVRMYAAFQDVFNWLPLTGLIATKILCMHGGLSPLMTkefTLDTLRKIERPTEG--KEGLVADLLWADPI
 |||||||.. .| .||| || ..|.      ...  |..|| ..||. |.  ||||.|||.|| ..   .|. ..||.|| .   .. |  |||.|||.
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispkle...sledikkikrplkevtedslaqdllfadpl

SGL--------SGF-MNNQRGAGCGFGRDSVLNLCSEFQLDLVCRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQCSFEILRP
 .           .  |. ||    |   .| ..|  ..|.|. ||||..  |. ||| .||.|||||| |  . ||  | .  | . . |  .||.
dvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrn
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 83-299 4.8e-67 219.4 In-house 121-334 (339) alignment 
Range on Protein: 83-299
Range on HMM: 121-334/339.0
NYLFLGDYVDRGRFSIETIVLLLAYKVKFPCNFFLLRGNHECEFVNKTYGFYEECQKRYQSvRMYAAFQDVFNWLPLTGLIATKILCMHGGLSPLMTKef
 ||||||||||| ||.| ..|| | |. .|   .|||||||   || .|||| | . ||.. ..| .||..|| .|.  .|   |.|||||.|  .|   
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyryda.qlyecfqnmfnvfpfcavinntimcmhggisehlts..

tLDTLRKIERPTEGK-EGLVADLLWADPISGLSGFMNNQRGAGCGFGRDSVLNLCSEFQLDLVCRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAA
 .. .  ..|| |    |...|| ||||     |.    |||   ||  ..  .  ...|..| | ||||.|||||| ||.|||||||| |||| || ||
.fnqfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaa

FMSCDEKLQCSFEILRPT
 .| |.||. | ...|| 
vfsidkklkisinvfrpe
PPP_5_Dcr2 56-251 1.9e-66 216.9 In-house 1-199 (199) alignment 
Range on Protein: 56-251
Range on HMM: 1-199/199.0
IKVCGDIHGQFPDL-LRLFHRGGWPP-TANYLFLGDYVDRGRFSIETIVLLLAYKVKFPCNFFLLRGNHECEFVNKTYGFYEECQKRYQSVRMYAAFQDV
. ||||.|||. || |.||..|| |. . .|.|||||||||..|.|...||||.|...| ...|||||||.| .|. |||..|....|.. ..| ...||
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FNWLPLTGLIATKILCMHGGLSPLMTkefTLDTLRKIERPTEGK--EGLVADL-LWADPISGLSG-FMNNQRGAGCGFGRDSVLNLCSEFQLDLVCRAHQ
|.||||. ||. |.|..|||||| .    ....|.||||..| .  .|  ||| ||.|| .  .| . |..||||. ||.| . ..... .|.|..|.|.
fdwlPlaalidekvlvvhgglspeik...siellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshe

VV
..
lk
subfamily_PPPLV_pd Subfamily PPPLV 33-284 2.3e-56 184.3 In-house 3-275 (290) alignment 
Range on Protein: 33-284
Range on HMM: 3-275/290.0
LKLLDLALGVFKAQKPMVEVNAPIKVCGDIHGQFPDLLR---LFHRGG-WPPTANYLFLGDYVDRGRFSIETIVLLLAYKVKFPCNFFLLRGNHECEFVN
| | | |. .. |.. ..|...|. | ||.||.. ||      . | |     |..|||||||||| ||.| |  ||| || .|  ..||||||| | | 
lslcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvq

KTYGFYEECQKRYQ--SVRMYAAFQDVFNWLPLTGLIATKILCMHGGLS-PLMTKEFT---LDTLRKIERPTEGKEgLVADLLWADPISG----------
... .. |.. ..      .. ||..||..|||.  |  |..|.|.|.  . ||. ..    | | ... . .|   |  |.||.|| ..          
esieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgap.laldilwsdpaedrdlslrgelv

-LSGFMNN-QRGAGCGFGRDSVLNLCSEFQLDLVCRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMS
   ||..| .|| |. |. |.. ..  . .|. | |||.| . |...  . .|.|.||. .|||. .. |  . 
lneGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssneaalilv
subfamily_PPP7C_pd Subfamily PPP7C 28-192 8.5e-42 136.2 In-house 34-201 (383) alignment 
Range on Protein: 28-192
Range on HMM: 34-201/383.0
TEERVLKLLDLALGVFKAQKPMVEVN----APIKVCGDIHGQFPDLLRLFHRGGWPPTA-NYLFLGDYVDRGRFSIETIVLLLAYKVKFPCNFFLLRGNH
  . ||..|  |  |.|. . . .|.      . ||||.||.. ||| .... | | .  .|.| ||.||||. |.| ...|||. . .| ...| ||||
hakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnh

ECEFVNKTYGFYEECQKRY--QSVRMYAAFQDVFNWLPLTGLIATKILCMHGGLSplmtKEFTLDTLRKIER
|   .|  |||  | ...|  .. .. . ..||| ||||. ||  ||| .|||.|    ..  |. | ||||
edhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGis....dktdlelldkier
Metallophos Calcineurin-like phosphoesterase 55-251 9.1e-42 136.6 Pfam-A 2-199 (200) alignment 
Range on Protein: 55-251
Range on HMM: 2-199/200.0
PIKVCGDIHGQFPDL----LRLFHRGGWPPTANYLFLGDYVDRGRFSIETIVLL--LAYKVKFPCNFFLLRGNHECEFVNKTYGFYEECQK---------
.| |.||.||.. ||    |.|.. .. ..  ..|||||.||||. |.||. ||  |..|...| ..||||||||. ..|. |||..|. |         
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------RYQSVRMYAAFQDVFNWLPLTGLIATKILCMHGGLSPLMTKEFTLdtlrkierptegkeglvadllwadpisglsg
                         .   . .......|..|||  |.  |||..||.||.    . .                                
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

fmnnqrgAGCGFGRDSVLNLCSEFQLDLVCRAHQVV
       ... ||.| . .|. . ..|||.|.|. .
.......gselfgpdalekllekygvdlvlrGHtHk
subfamily_PPP7C_pd Subfamily PPP7C 201-291 9.1e-19 60.4 In-house 237-327 (383) alignment 
Range on Protein: 201-291
Range on HMM: 237-327/383.0
VADLLWADPISGLSGFMNNQRGAGCGFGRDSVLNLCSEFQLDLVCRAHQVVQDGYEFFAGRKLVTIFSAPHYCGQFDNCAAFMSCDEKLQC
| |.||.|| .    . |  ||.|. || |   .| . ..|.|. |.|.  ..||||   .|..|||||  |  .  |  |..   ..|. 
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltp
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 25-81 3.1e-11 36.0 In-house 7-63 (317) alignment 
Range on Protein: 25-81
Range on HMM: 7-63/317.0
KVITEERVLKLLDLALGVFKAQKPMVEVNAPIKVCGDIHGQFPDLLRLFHRGGWPPT
....|. ...|   |  .|  .. ..|..||....||||||| ||| |..  ||| .
dlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwpls
subfamily_YNL217W_pd Subfamily YNL217W 54-176 1.5e-07 24.1 In-house 10-138 (235) alignment 
Range on Protein: 54-176
Range on HMM: 10-138/235.0
APIKVCGDIHGQFPDLLRLFH--RGGWPPTANYLFLGDYVDRGRFSIETIVLLlaYKVKFPCnfflLRGNHECE------FVNKTYGFYEE-CQKRYQSV
  . | ||.|| . .|..|..   ||  . .  ...|| ...|  |.|.. ..   |..  |    ..||||        .| |  |. .    .... .
krllvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv..rkdqvkc....vkGnheelvllaykwvkkpkgaeplefsskfsfl

--RMYAAFQDVFNWLPLT-GLIATKILCMHGGLSP
  ..  |  .    |. .  . ....| .|.||.|
esklskadmeyarelgfsldipsdellvvhaGlvp
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 49-80 4.3e-07 22.3 In-house 33-64 (339) alignment 
Range on Protein: 49-80
Range on HMM: 33-64/339.0
MVEVNAPIKVCGDIHGQFPDLLRLFHRGGWPP
.....||| | ||||||| ||| ..   ||| 
flkleapicvmgdihgqfddllamldmngwpl