Gene F22D6.9 in Caenorhabditis elegans

Synonym: CELE_F22D6.9, CELE_F22D6.9

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily CelePPP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP066_AA protein Get Run
CeleP066_AA_36-353 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 37-352 1.7e-179 588.9 In-house 1-316 (317) alignment 
Range on Protein: 37-352
Range on HMM: 1-316/317.0
SPVNCQDMLKRYEIYELCLRARELFWTQPLYRHVEVPVTIVGDIHGQFEDLKMMMDMNGWPFTEDEAKEMCKNLLLKGGKDGKQTFPAVLGSGTDRQKTQ
||..|||..|..|..|||.|||||||..||....|.|||||||||||||||....|.||||....|.|...|.|||...||.|||..||........|..
spkkcqdlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwplssqeeksepkslllesskdvkqtvaavksvnkevtkgy

KNYLFLGDYVDRGPYSIEVVLMLFAMHLRWPDRVTLLRGNHESRPVNRQYGFYGECVRRYSERIYEVFQLAFNAMPLTAIVNKRIMCMHGGISEELFDLK
|.||||||||||||.|||||..|||..|..||.|.||||||||||||.||||| |. .|||...||.||||||..||.|.|||.|.||||||||||.|||
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldlk

QLDALKRPIDTPDIGIIADLTWADPECEIDYYKESPRGAGKIFGAKAVDEFCKHFQLDLIVRAHQVVQDGYEFFADRKLVTIFSAPFYCGQTNNIASMLN
|||.||||.|.||.|..||||||||..|...||||.|||||.||||||.||.|...|||.|||||||.||||||||||||||||||.||||..|||..|.
qldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavls

IDKDMVASFMLVKPVT
.||....|.....| .
vdkklkisinvlrpes
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 38-350 8.3e-172 563.1 In-house 1-282 (284) alignment 
Range on Protein: 38-350
Range on HMM: 1-282/284.0
PVNCQDMLKRYEIYELCLRARELFWTQPLYRHVEVPVTIVGDIHGQFEDLKMMMDMNGWPFTEDEAKEmcknlllkggkdgkqtfpavlgsgtdrqktqK
|||||..||..|..|||.|||||||...|....|.||.||||||||||||....|.|||||.||||||                               |
pvncqkllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeake...............................k

NYLFLGDYVDRGPYSIEVVLMLFAMHLRWPDRVTLLRGNHESRPVNRQYGFYGECVRRYSERIYEVFQLAFNAMPLTAIVNKRIMCMHGGISEELFDLKQ
.||||||||||||.||||...|||..|..||.|.||||||||||||.||||| ||..||||..||.||||||||||.|.|.|.|.||||||||.|.||||
kylflgdyvdrgpfsievitllfayklllpdkvfllrgnhesrpvnmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkq

LDALKRPIDTPDIGIIADLTWADPECEIDYYKESPRGAGKIFGAKAVDEFCKHFQLDLIVRAHQVVQDGYEFFADRKLVTIFSAPFYCGQTNNIASMLNI
||.|.||||.||||.||||||||||.|...||||||||||.||||||.||.|.|.|||.|||||||.||||||||||||||||||.||||..|||..||.
ldklerpidipdigviadltwadpeaevegykesprgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnv

DKDMVASFMLVKP
|...||||...||
deelvasftvlkp
PP2Ac_SM00156 46-350 2.3e-106 347.8 In-house 2-269 (271) alignment 
Range on Protein: 46-350
Range on HMM: 2-269/271.0
KRYEIYELCLRARELFWTQPLYRHVEVPVTIVGDIHGQFEDLKMMMdmngwpftedeakemcknlllkggkdgkqtfpavlgSGTDrQKTQKNYLFLGDY
.. |..||. ...|..  ..  ..|. |||.|||||||..||  ..                                    . .. . ....|.|||||
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrll....................................elag.eppeekyvFlGdY

VDRGPYSIEVVLMLFAMHLRWPDRVTLLRGNHESRPVNRQYGFYGECVRRYSERIYEVFQLAFNAMPLTAIVNKRIMCMHGGISEELFDLKQLDALKRPI
|||||.||||.|.|||.....|..|.||||||||..||. |||. |. |.|...|||.|. ||...||.|.|...|.|||||.|.||  |.... |||. 
VDRGpqsiEvillLfalkilypekvvLLRGnHEsssvnkiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvk

DTPDIGIIADLTWADPECEIDYYKESPRGAGKIFGAKAVDEFCKHFQLDLIVRAHQVVQDGYEFFADRKLVTIFSAPFYCGQTNNIASMLNIDKDMVASF
..|. |...||.|.||| . . .. | ||.. .||..||.||.|...|.||.|||.||..|||||||.||||||||| ||....| |..|...|.. .|.
ekpeegllidllwsdpeqkekgfqpskrglsvvFgedavkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsi

MLVKP
 ..|.
eqlke
subfamily_PPP1C_pd Subfamily PPP1C 43-352 7.3e-104 339.9 In-house 8-280 (282) alignment 
Range on Protein: 43-352
Range on HMM: 8-280/282.0
DMLKRYEIYELCLRARELFWTQPLYRHVEVPVTIVGDIHGQFEDLKMMMDMNGWPFTEdeakemcknlllkggkdgkqtfpavlgsgtdrqktqkNYLFL
 .||. || .|. .|||.. .||   ..| ||.||||||||..||  .....| | ..                                     |||||
vklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpes.....................................nylfl

GDYVDRGPYSIEVVLMLFAMHLRWPDRVTLLRGNHESRPVNRQYGFYGECVRRYSERIYEVFQLAFNAMPLTAIVNKRIMCMHGGISEELFDLKQLDALK
|||||||  |.|....|.|.....|... ||||||||  .|| |||| || |||| .....|. .|| .||.|.|...|.|.|||.|.|| .|.|.. ..
GdyvdrGkqsletivlllaykikypenlfllrGnhesasinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiq

RPIDTPDIGIIADLTWADPECEIDYYKESPRGAGKIFGAKAVDEFCKHFQLDLIVRAHQVVQDGYEFFADRKLVTIFSAPFYCGQTNNIASMLNIDKDMV
||.. |. |...|| |.||. |.  ..|. ||    ||...|..|.....|||||||||||.|||||||.|.|||.|||| |||. .| ...|..|....
rPlevpekgllcdllWsdpdkevlgwsendrGvsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeell

ASFMLVKPVT
 || ..||..
vsfqilkpak
0045823 Metallo-dependent phosphatases 42-352 5e-99 325.0 In-house 40-325 (473) alignment 
Range on Protein: 42-352
Range on HMM: 40-325/473.0
QDMLKRYEIYELCLRARELFWTQPLYRHVEVPVTIVGDIHGQFEDLKMMMDMNGWPFTeDeakemcknlllkggkdgkqtfpavlgsgtdrqktqkNYLF
. .|.  ....|. .|.|... .|   ... .....||||||..||. .....|.|   |                                    ...|
egllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppe.d....................................rlvf

LGDYVDRGPYSIEVVLMLFAMHLRWPDRVTLLRGNHESRPVNRQYGFYGECVRRYSERIYEVFQLAFNAMPLTAIVNKRIMCMHGGISEELFDLKQLDAL
|||.|||||.|.||.. |.|. ...|..|.|||||||.| .|  |||..|. ..|.|..|| |.  ....||.|.....| ..|||.| .|  |.|....
lGDlvDrGpdslevlelllalkikypgnvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqirei

KRPIDTPDIGIIADLTWADPeCEIDY--------YKESPRGAGKIFGAKAVDEFCKHFQLDLIVRAHQVVQDGYEFFADRK------LVTIFSAPFYCGQ
.||.. || |.. || |.||  |.|.        .  |||||| .||..||.||.|...||||||.|..|..|||.. |.|      ..|.|||| |||.
erpleipddgllldllwsdP.weddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgr

TNNIASMLNIDKDMvASFMLVKPVT
..| |..| ||.|.  || ...|. 
ggnlaAvlvidedl.isfiqfdpsp
0049330 Metallo-dependent phosphatases 37-353 4.9e-96 314.4 In-house 22-301 (309) alignment 
Range on Protein: 37-353
Range on HMM: 22-301/309.0
SPVNCQDMLKRYEIYELCLRARELFWTQPLYRHVEVPVTIVGDIHGQFEDLKMMMDMNGWPftedeakemcknlllkggkdgkqtfpavlgsgtdrqkTQ
. . .. .|.  |...|.|.|.|.....| . ... .....||||||..||. .....|.|                                       
elllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfp.....................................pe

KNYLFLGDYVDRGPYSIEVVLMLFAMHLRWPDRVTLLRGNHESRPVNRQYGFYGECVRRYSERIYEVFQLAFNAMPLTAIVNKRIMCMHGGISEELFDLK
 ...||||.|||||.|.||.|.|.|. |..||.|.|||||||.| .|. |||..|..|.|.....| |.  ....||.|.....|.|.|||.| .|  |.
drlvflGDlvdrGpdslevlllllalkllypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllld

QLDALKRPIDTPDIGIIADLTWADPECEIDYYKESPRGAGKIFGAKAVDEFCKHFQLDLIVRAHQVVQDGYEFFADRKLVTIFSAPFYCGQTNNIASMLN
|...|.||.. |. |...||.|.||  ... . ..|||.| .||. ||..|.|...||||.|.|..|..||..|.|.||.|.|||| |||...| ...| 
qirelerpleipldgllcdllwsdplpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavle

IDKDMVASFMLVKPVTE
||.|.| ||.| .||. 
idedlvisfllfepvpl
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 135-352 8e-95 310.3 In-house 77-295 (298) alignment 
Range on Protein: 135-352
Range on HMM: 77-295/298.0
TQKNYLFLGDYVDRGPYSIEVVLMLFAMHLRWPDRVTLLRGNHESRPVNRQYGFYGECVRRY-SERIYEVFQLAFNAMPLTAIVNKRIMCMHGGISEELF
 ..|||||||||||| ...||...|.|  ...|... |||||||   .||.|||| || ||| | |.|. || .|||.||||.. .||.|||||.|..| 
pdanylflGdyvdrGrqnlevivlllaykvkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklk

DLKQLDALKRPIDTPDIGIIADLTWADPECEIDYYKESPRGAGKIFGAKAVDEFCKHFQLDLIVRAHQVVQDGYEFFADRKLVTIFSAPFYCGQTNNIAS
 |.|| .||||.|...  . .|| |||||  .  ..|. ||.. .||...| ........||.|||||||||||||||..|||||||||.|||| .| |.
sldqlrelkrpfdskeeslaidllwadpenavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaa

MLNIDKDMVASFMLVKPVT
....|...| || ..|| .
vmkvdeklvvsfevlkpek
0053225 Metallo-dependent phosphatases 38-352 6.9e-88 287.8 In-house 15-292 (293) alignment 
Range on Protein: 38-352
Range on HMM: 15-292/293.0
PVNCQDMLKRYEIYELCLRARELFWTQPLYRHVEVPVTIVGDIHGQFEDLKMMMDMNGWPftedeakemcknlllkggkdgkqtfpavlgsgtdrqkTQK
 . .. .|. .|...|.| |.|.....| . ... .....|||||...||. .... |.|                                        
lllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfp.....................................ped

NYLFLGDYVDRGPYSIEVVLMLFAMHLRWPDRVTLLRGNHESRPVNRQYGFYGECVRRY-SERIYEVFQLAFNAMPLTAIVNKRIMCMHGGISEELFDLK
...||||.|||||.|.||...|.|. |..||.|.|||||||.. .|  |||..|..|.| ...... ..  ....||.|.....|...|||.| .|  |.
rlvflGDlvdrGpdslevlelllalkllypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslld

QLDALKRPIDTPDIGIIADLTWADPEcEIDYYKESPRGAGKIFGAKAVDEFCKHFQLDLIVRAHQVVQDGYEFFADRKLVTIFSAPFYCGQTNNIASMLN
|.. ..||.. |. |...|| | ||  ... .  |.||.| .||. ||..|.|...||||.|.||||.|||... |.||||.|||| |.|...| ...| 
qireinrplriplegllldllwsdpd.lwsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavla

IDKDMVASFMLVKPVT
.|...| .| | .|| 
ldeglvwgfklfapvl
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 135-351 1.4e-85 280.4 In-house 118-334 (339) alignment 
Range on Protein: 135-351
Range on HMM: 118-334/339.0
TQKNYLFLGDYVDRGPYSIEVVLMLFAMHLRWPDRVTLLRGNHESRPVNRQYGFYGECVRRYSERIYEVFQLAFNAMPLTAIVNKRIMCMHGGISEELFD
  | ||||||||||||.|.|||..| |..| .|||. ||||||||| ||  |||| |   ||  ..||.||  || .|. |..|. |||||||||| |  
gykrylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehlts

LKQLDALKRPIDTPDIGIIADLTWADPECEIDYYKESPRGAGKIFGAKAVDEFCKHFQLDLIVRAHQVVQDGYEFFADRKLVTIFSAPFYCGQTNNIASM
..|.  .|||.. ||.|...|||||||.     || | |||  .||  |.  | |...|....| ||||.||||||  |.|||||||| |||| .| |..
fnqfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaav

LNIDKDMVASFMLVKPV
. ||| .  |  ...| 
fsidkklkisinvfrpe
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 136-354 5.2e-85 278.0 In-house 60-279 (280) alignment 
Range on Protein: 136-354
Range on HMM: 60-279/280.0
QKNYLFLGDYVDRGPYSIEVVLMLFAMHLRWPDRVTLLRGNHESRPVNRQYGFYGECVRRYSERIYEVFQLAFNAMPLTAIVNKRIMCMHGGISEELFDL
..|||||||||||| . .||.|.|.| ..|.|..  .||||||   .||.|||. |. ||||. .|. ||  .. .||.|.|. ||.|||||.|..|  |
dqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisinrkygfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvsl

KQLDALKRPIDTPDIGIIADLTWADPECEIDYYKESPRGAGKIFGAKAVDEFCKHFQLDLIVRAHQVVQDGYEFFADRKLVTIFSAPFYCGQTNNIASML
..|  |.||.|..|  .  || ||||| ..  . |..||. .||||. | ........|||.| |||||||||||||.||||.|||| |.|. .| |..|
ddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavl

NIDKDMVASFMLVKPV-TEI
 .|. .. || ..||   |.
ivderlivsfevlkpalrev
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 135-352 4.7e-82 268.6 In-house 77-295 (299) alignment 
Range on Protein: 135-352
Range on HMM: 77-295/299.0
TQKNYLFLGDYVDRGPYSIEVVLMLFAMHLRWPDRVTLLRGNHESRPVNRQYGFYGECVRRY-SERIYEVFQLAFNAMPLTAIVNKRIMCMHGGISEELF
 . |.||||||||||   .|.. .|.......|.|  .||||||   .|| |||| || .|| | |.. .|| ||.||||| ... ||.|||||.| .| 
pdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklq

DLKQLDALKRPIDTPDIGIIADLTWADPECEIDYYKESPRGAGKIFGAKAVDEFCKHFQLDLIVRAHQVVQDGYEFFADRKLVTIFSAPFYCGQTNNIAS
.| ||  | || | |.  .  || ||||.  .  ..   ||   .|| . | . ......||. ||||||||||||||..||||||||| |||| .| |.
tldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaa

MLNIDKDMVASFMLVKPVT
....|...|..|...|| .
imkvdenlvctfvvlkptp
PPP_3 133-348 5.8e-80 261.2 In-house 53-269 (271) alignment 
Range on Protein: 133-348
Range on HMM: 53-269/271.0
QKTQKNYLFLGDYVDRGPYSIEVVLMLFAMHLRWPDRVTLLRGNHESRPVNRQYGFYGECV-RRYSERIYEVFQLAFNAMPLTAIVNKRIMCMHGGISEE
.  ...||||||||||| .|.||.|.|.|. ...|..|.||||||||| .|. |||. |.. .......|...|  |...||.|.........|||.|..
pspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrqinkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlsps

LFDLKQLDALKRPIDTPDIGIIADLTWADPECEIDYYKESPRGAGKIFGAKAVDEFCKHFQLDLIVRAHQVVQDGYEFFADRKLVTIFSAPFYCGQTNNI
.  |.|.  |.|.|..|. | . ||.. ... . . ...|.|||| .||.....||... .|.||.|||.....|||...|.|.||.|||| ||....| 
iksldqikklerkievpeegklldlllssdpekeeglenskrGagllFgpdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasna

ASMLNIDKDMVASFMLV
...|......  .| ..
gailkleealtsefkql
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 134-350 5.8e-80 261.3 In-house 62-281 (287) alignment 
Range on Protein: 134-350
Range on HMM: 62-281/287.0
KTQKNYLFLGDYVDRGPYSIEVVLMLFAMHLRWPDRVTLLRGNHESRPVNRQYGFYGECVRRYSERIYEVFQLAFNAMPLTAIVNKRIMCMHGGISEELF
 .. .|||||||||||. |.||.|.||.. ...| .| ||||||| . .|..|||. |  |...||.|..|.  |. .|| |.|.|||.|||||||..| 
apkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkkinklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklk

DLKQLDALKRPIDTPDI--GIIADLTWADPECEIDYYK-ESPRGAGKIFGAKAVDEFCKHFQLDLIVRAHQVVQDGYEFFADRKLVTIFSAPFYCGQTNN
 |..| |||.|    .   |.. || ||||| . . .. .  |.  ..|| | ||...|....|||||||.|...||.|..|..|||.||||.|.|.  |
sldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtn

IASMLNIDKDMVASFMLVKP
..... ..| .  ||. .||
lgavvvvskslelsfvvlkp
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 134-351 2.7e-78 256.0 In-house 60-277 (281) alignment 
Range on Protein: 134-351
Range on HMM: 60-277/281.0
KTQKNYLFLGDYVDRGPYSIEVVLMLFAMHLRWPDRVTLLRGNHESRPVNRQYGFYGECVRRYSERIYEVFQLAFNAMPLTAIVNKRIMCMHGGISEELF
 ... ..|||||||||| |.||...||....|..||. |||||||   ||..|||| ||| .| | ..  ||  || .|..| ..||..|||||.| || 
vpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvnkiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPelt

DLKQLDALKRPIDTPDIGIIADLTWADPECEIDYYKESPRGAGKIFGAKAVDEFCKHFQLDLIVRAHQVVQDGYEFFADRKLVTIFSAPFYCGQTNNIAS
 | .|    .||. .| |.. || ||||. .   .|.| ||.. .|| . ||. ||.....||.||||||||||| .. |||.|.||.| || . .| |.
aldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaa

MLNIDKDMVASFMLVKPV
.| .|...  |.. . | 
vlkvdetlgislvalvpa
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 136-355 7.8e-78 254.7 In-house 57-278 (284) alignment 
Range on Protein: 136-355
Range on HMM: 57-278/284.0
QKNYLFLGDYVDRGPYSIEVVLMLFAMHLRWPDRVTLLRGNHESRPVNRQYGFYGECVRRYSE-RIYEVFQLAFNAMPLTAIVNKRIMCMHGGISEELFD
. |||||||||||| . .| .|.||| .. .|... .||||||   .|..|||| || ||| .  .|  |.  |  |||||.| .||.|||||.|. | .
ranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinkiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqn

LKQLDALKRPIDTPDIGIIA-DLTWADPECEIDYYKESPRGAGKIFGAKAVDEFCKHFQLDLIVRAHQVVQDGYEFFADRKLVTIFSAPFYCGQTNNIAS
. || |.|||.| |.   .| |. |.||      ..   ||   .||. |. ..  ..|.||.|||||||||||||||.|.||||||||||||| .| |.
vsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaa

MLNIDKDMVASFMLVKPVTEIK
.. ..|..|.||....|  .| 
vmyvnknlvcsfvvlrprkkia
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 135-352 9.4e-75 244.6 In-house 76-296 (297) alignment 
Range on Protein: 135-352
Range on HMM: 76-296/297.0
TQKNYLFLGDYVDRGPYSIEVVLMLFAMHLRWPDRVTLLRGNHESRPVNRQYGFYGECVRRY-SERIYEVFQLAFNAMPLTAIVNKRIMCMHGGISE---
   |||||||||||| .||| ...|.| ....|  . |||||||   ||. |||| || .|| | |.|  ||  || .||| .. ..|.|||||.|    
ptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglspllt

ELFDLKQLDALKRPIDTPDiGIIADLTWADPECEIDYYKESPRGAGKIFGAKAVDEFCKHFQLDLIVRAHQVVQDGYEFFADRKLVTIFSAPFYCGQTNN
. | |. |  ..|. .  . ...||| ||||   .  . |  ||||  ||  || . | .|.|||..|||||||||||||| |||||||||| |||| .|
keftldtlrkierstegke.rlvadllwadpisglsgfmenqrgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdn

IASMLNIDKDMVASFMLVKPVT
 |...  |. . .|| ...| .
caafmscdeklqcsfeilrpts
PPP_1 134-336 1.1e-73 240.8 In-house 53-263 (264) alignment 
Range on Protein: 134-336
Range on HMM: 53-263/264.0
KTQKNYLFLGDYVDRGPYSIEVVLMLFAMHLRWPDRVTLLRGNHESRPVNRQYGFYGECV-RRYSERIYEVFQLAFNAMPLTAIVNKRIMCMHGGISEEL
  ..|||||||||||| .|.|..|.|.|. |..|....||||||||| |.. |||. |.. ..||..||.... .|. .||.|.....|...|||.|.||
spetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvtkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspel

FDLKQLDALKRPIDTPDIGIIADLT-------WADPECEIDYYKESPRGAGKIFGAKAVDEFCKHFQLDLIVRAHQVVQDGYEFFADRKLVTIFSAPFYC
  |.|   ..| ...|. | . ||.       . |.. . .  ..|.|||| .||......|.....|.||.|||.|...||||...||.||||||. |.
dlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRGagylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyy

GQTNNIASMLN
 ...| .....
eegsnrgayvk
subfamily_PPP4C_pd Subfamily PPP4C 134-348 5.1e-73 238.8 In-house 68-282 (288) alignment 
Range on Protein: 134-348
Range on HMM: 68-282/288.0
KTQKNYLFLGDYVDRGPYSIEVVLMLFAMHLRWPDRVTLLRGNHESRPVNRQYGFYGECVRRYS-ERIYEVFQLAFNAMPLTAIVNKRIMCMHGGISEEL
  ..|||||||.|||| ||.|  |.| |...|.|||.||.||||||| . . |||| ||.|.|   .....    |. ..|.||....|.|.|||.| ..
vpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsi

FDLKQLDALKRPIDTPDIGIIADLTWADPEcEIDYYKESPRGAGKIFGAKAVDEFCKHFQLDLIVRAHQVVQDGYEFFADRKLVTIFSAPFYCGQTNNIA
  | .. .. | .. |. |...|| |.||| ... .  ||||||..||...|..|... ...||.||||.|..|| .  ..|..|..||| || .  |.|
stldeirsidrkqevphegplcdllwsdpe.daegwavsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnva

SMLNIDKDMVASFMLV
..|..|...   |.. 
aileldeeldkdfkif
subfamily_PPP2C_pd Subfamily PPP2C 135-350 4.8e-70 229.0 In-house 70-285 (290) alignment 
Range on Protein: 135-350
Range on HMM: 70-285/290.0
TQKNYLFLGDYVDRGPYSIEVVLMLFAMHLRWPDRVTLLRGNHESRPVNRQYGFYGECVRRYSE-RIYEVFQLAFNAMPLTAIVNKRIMCMHGGISEELF
 . |||||||||||| ||.| | .| |...|...|.|.|||||||| . . ||||.||.|.|..  ....|   |. .||||.|...|.|.|||.| .. 
pdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsid

DLKQLDALKRPIDTPDIGIIADLTWADPEcEIDYYKESPRGAGKIFGAKAVDEFCKHFQLDLIVRAHQVVQDGYEFFADRKLVTIFSAPFYCGQTNNIAS
 | .. ||.|  . |. | ..|| |.||. . . .  ||||||  || .  ..| |. .| ||.||||.| .||..  ||..||||||| || .  | |.
tldkiraldrlqevphegplcdllwsdpd.drggwgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaa

MLNIDKDMVASFMLVKP
.|..|...  ||.  .|
ilelddklkysflqfdp
subfamily_PPP3C_pd Subfamily PPP3C 45-342 6.3e-70 229.2 In-house 41-314 (452) alignment 
Range on Protein: 45-342
Range on HMM: 41-314/452.0
LKRYEIYELCLRARELFWTQPLYRHVEVPVTIVGDIHGQFEDLKMMMDMNGwpftedeakemcknlllkggkdgkqtfpavlgsgtdrQKTQKNYLFLGD
|.. .. ..  .| .|. ...   .|| |.|..||||||| ||  .....|                                     . .. .||||||
leeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgG.....................................dPastkylflGd

YVDRGPYSIEVVLMLFAMHLRWPDRVTLLRGNHESRPVNRQYGFYGECVRRYSERIYEVFQLAFNAMPLTAIVNKRIMCMHGGISEELFDLKQLDALKRP
||||| .|||.|| |.|. . .|... |||||||.| .   . |  ||  .|||..|. .  .|...||.|..|.. .|.|||.| |. .|.... |.| 
yvdrGyfsiecvlylyalkiaypstlfllrGnhecrhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrf

IDTPDIGIIADLTWADPE-------CEIDYYKESPRGAGKIFGAKAVDEFCKHFQLDLIVRAHQVVQDGYEFFAD------RKLVTIFSAPFYCGQTNNI
 . |  | . || |.||         | .. ..|.||   ... ||| || .. .|  |.|||.. ..||. . .        |.|.|||| |..  || 
keppasGplcdllWsdPledygeekteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnk

ASMLNIDKDMV
|..|..... .
aavlkyennvm
subfamily_PPP6C_pd Subfamily PPP6C 134-353 2.3e-69 226.7 In-house 67-286 (290) alignment 
Range on Protein: 134-353
Range on HMM: 67-286/290.0
KTQKNYLFLGDYVDRGPYSIEVVLMLFAMHLRWPDRVTLLRGNHESRPVNRQYGFYGECVRRYSE-RIYEVFQLAFNAMPLTAIVNKRIMCMHGGISEEL
  ...|.||||.|||| ||.| . .|.......|||.|||||||||| . . |||| ||...| .   .  .   |. ....||......|.|||.| ..
vpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdv

FDLKQLDALKRPIDTPDIGIIADLTWADPEcEIDYYKESPRGAGKIFGAKAVDEFCKHFQLDLIVRAHQVVQDGYEFFADRKLVTIFSAPFYCGQTNNIA
  |.|.  ..| .. |  | ..|| |.||| ... .. |||||| .||.| ..||..  .|.||.||||.|..|.... | ||||..||| || .  |.|
ktldqirvieraqeiphkgafcdlvwsdpe.dvetwavsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnva

SMLNIDKDMVASFMLVKPVTE
|.|.....   .. | | | .
silaledaeereaklfkavpd
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 137-350 5.2e-69 225.4 In-house 71-288 (290) alignment 
Range on Protein: 137-350
Range on HMM: 71-288/290.0
KNYLFLGDYVDRGPYSIEVVLMLFAMHLRWPDRVTLLRGNHESRPVNRQYGFYGECVRRYSERIYEVFQLAFNAMPLTAIVNKRIMCMHGGISEELFDLK
 ..||||||||||. |.|| |.|| ...|.. .| ||||||| | ||| |||. | .|. . |.. ..|  |. ..| | |...|.|||||||...   .
vkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrkvnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkieswe

QLDALKRPI--DTPDIGIIADLTWADPEC-EIDY-YKESPRGAGKIFGAKAVDEFCKHFQLDLIVRAHQVVQDGYEFFADRKLVTIFSAPFYCGQTNNIA
 | |||.|    | | |.. || ||||.    |    .  |.   .|| |..|...|.. |.||||||.| ..|..|  |.||||.||||.|.|.  |. 
slkalkkprvpltcdeglqvdllwadptrdkddtialnkqraisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlg

SMLNIDKDMVASFMLVKP
..... . .  |.. .||
aiatvseslelsivvlkp
subfamily_PPZ_pd Subfamily PPZ 136-351 9.8e-68 221.8 In-house 79-294 (300) alignment 
Range on Protein: 136-351
Range on HMM: 79-294/300.0
QKNYLFLGDYVDRGPYSIEVVLMLFAMHLRWPDRVTLLRGNHESRPVNRQYGFYGECVRRYSERIYEVFQLAFNAMPLTAIVNKRIMCMHGGISEELFDL
. ||||||||||||  |.| .|.|.. ....|. . |||||||   | | |||| || ||   .|.. |  .||..||.|||  .|.|.|||.|  |  .
sanylflgdyvdrgkqsletillllcykikypenffllrgnhecanvtrvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsm

KQLDALKRPIDTPDIGIIADLTWADPECEIDYYKESPRGAGKIFGAKAVDEFCKHFQLDLIVRAHQVVQDGYEFFADRKLVTIFSAPFYCGQTNNIASML
 ..  . || | ||.|.| || |.||    . ...  ||    .   |...| ..| .||..||| ||.|||||| || |||.|||| |||. .|  ...
deirhvvrptdvpdfglindllwsdptdssnewednergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavm

NIDKDMVASFMLVKPV
.. . ...|| |. |.
svsegllcsfelldpl
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 137-349 3.4e-67 219.9 In-house 61-273 (280) alignment 
Range on Protein: 137-349
Range on HMM: 61-273/280.0
KNYLFLGDYVDRGPYSIEVVLMLFAMHLRWPDRVTLLRGNHESRPVNRQYGFYGECVRRYSERIYEVFQLAFNAMPLTAIVNKRIMCMHGGISEELFDLK
.. .||||||||||  |||...||....|. ||. |||||||.  ||. |||| ||  .|   ..  || .|| ||......||..|||||.| || .| 
eklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiygfyvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinld

QLDALKRPIDTPDIGIIADLTWADPECEIDYYKESPRGAGKIFGAKAVDEFCKHFQLDLIVRAHQVVQDGYEFFADRKLVTIFSAPFYCGQTNNIASMLN
 .  . ||..  | |.. || |.||  . . .  | ||   .||   |.. || ...|||.|||||||||||..| |.|.|.|| | || |  | |... 
tirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvc

IDKDMVASFMLVK
.. ..  ||  . 
lnanlqvsfqqli
subfamily_PPP5C_pd Subfamily PPP5C 135-343 3.1e-64 210.0 In-house 92-301 (322) alignment 
Range on Protein: 135-343
Range on HMM: 92-301/322.0
TQKNYLFLGDYVDRGPYSIEVVLMLFAMHLRWPDRVTLLRGNHESRPVNRQYGFYGECVRRYSERIYEVFQLAFNAMPLTAIVNKRIMCMHGGI-SEELF
... ||| ||.|||| .|.||.|.|....| .|... | ||||||  .|. ||| ||.  .|.|.....|.  || .||. ..|.... .|||. ||.  
eenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgv

DLKQLDALKRPIDTPDIGIIADLTWADPECEiDYYKESPRGAGKIFGAKAVDEFCKHFQLDLIVRAHQVVQDGYEFFADRKLVTIFSAPFYCGQTNNIAS
 |..|  ..|  . |. |.. .| |.||. .    ..| || |  ||    ..|.|. .|.||.|.|.| ..|||.  | ||.|.|||| || |..| ..
tlddlrkidrnaqppeegllvellwsdpqea.nGrspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkga

MLNI-DKDMVA
.... ..|.  
fitlrgddlkl
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 134-351 5.4e-63 206.1 In-house 32-256 (263) alignment 
Range on Protein: 134-351
Range on HMM: 32-256/263.0
KTQKNYLFLGDYVDRGPYSIEVVLMLFAMHLRWPDRVTLLRGNHESRPVNRQYGFYGECVRRYS-----ERIYEVFQLAFNAMPLTAIVNKRIMCMHGGI
 |. .||||||||||| .|.||...||...|  | .. ||||||| . .|..|||. |  .|.      | .|. |.  |. ||| |||.|||.||||||
atktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesvynhfnqvfsymplcaivskrilcmhggi

SEELFDLKQLDALKRPIDTPDIG-IIADLTWADPECEIDYYK-ESPRGAGKIFGAKAVDEFCKHFQLDLIVRAHQVVQDGYEFFADRKLVTIFSAPFYCG
|  |  | .. |.  |..|     . .|| ||||| .   .. .  |   ..|| | ||..||....||||||||||. || |||||.|.|.|||  |  
sphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidlivrahqvveygyaffadrrlitvfsasryqi

QTNNIASMLNIDKDMVASFMLVKPV
.  | |... ..| .  ||. .|| 
elcnyaavvvvnkmlelsfvqlkpe
subfamily_PPG1_pd Subfamily PPG1 135-341 5.8e-61 199.4 In-house 67-286 (300) alignment 
Range on Protein: 135-341
Range on HMM: 67-286/300.0
TQKNYLFLGDYVDRGPYSIEVVLMLFAMHLRWPDRVTLLRGNHESRPVNRQYGFYGECVRRY--SERIYEVFQLAFNAMPLTAIVNKRIMCMHGGISEEL
 . |||||||||||| ||.| . .| ...||.| |.|||||||||| . . ||||.||.|.|    |... .   |. . |.||... |.|.|||.| . 
pdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsv

FDLKQLDALKRPIDTPDIGIIADLTWADPE-----------CEIDYYKESPRGAGKIFGAKAVDEFCKHFQLDLIVRAHQVVQDGYEFFADRKLVTIFSA
  . |.  | |  . |. | .||| |.|||            | .....|.||||  .| . | .| .  ... |.||||....||. . | || |..||
lsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsa

PFYCGQTNNIASMLNIDKDM
| || .  | ||.|.. .  
pnycyrcgnkasilelyekd
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 137-354 7.5e-61 199.0 In-house 75-295 (307) alignment 
Range on Protein: 137-354
Range on HMM: 75-295/307.0
KNYLFLGDYVDRGPYSIEVVLMLFAMHLRWPDRVTLLRGNHESRPVNRQYGFYGECVR---RYSERIYEVFQLAFNAMPLTAIVNKRIMCMHGGISEELF
  |.| |||||||  |.|..|.||.... .|. . |||||||   ||..|||| |||    .  | |. .|| .|| .|..|..  .|.|||||.|  | 
tvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspalt

DLKQLDALKRPIDTPDIGIIADLTWADPECEIDYYKESPRGAGKIFGAKAVDEFCKHFQLDLIVRAHQVVQDGYEFFADRKLVTIFSAPFYCGQTNNIAS
 | .|    .||  |  ||. |. ||||.  .  .| | ||.|  ||.. .|. || . ..||.||||.. |||  .. |||.||||||.||   .|   
cldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagc

MLNIDKDMVASFMLVKPVTEI
.|..|. .    . . | .| 
vlkvdetlgiqlvafvpesen
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 136-344 8.5e-59 192.2 In-house 71-293 (302) alignment 
Range on Protein: 136-344
Range on HMM: 71-293/302.0
QKNYLFLGDYVDRGPYSIEVVLMLFAMHLRWPDRVTLLRGNHESRPVNRQYGFYGECVRRYSE----RIYEVFQLAFNAMPLTAIVNKRIMCMHGGISEE
.. ..|||||||||. ||| . ..||. . .| .  |||||||.. .|  ||| .| . |...    .|.| |. .|  |||.|.| ..|.|.|||||. 
sdkfvflGdyvdrGsksieciclvfalkvlyptnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispk

LFDLKQLDALKRPID-TPDIGIIADLTWADPE---------CEIDYYKESPRGAGKIFGAKAVDEFCKHFQLDLIVRAHQVVQDGYEFFADRKLVTIFSA
|  |.... .|||.    .  .  || .|||           . .| |.  ||   .|   || ..||...|.|||||||..  |. ||||.||.|||||
lesledikkikrplkevtedslaqdllfadpldvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsa

PFYCGQTNNIASMLNIDKDMVAS
| |  ...|  ..|..| .   |
prymnesdnkGavlkvdtngkls
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 136-343 1.6e-58 191.2 In-house 72-293 (302) alignment 
Range on Protein: 136-343
Range on HMM: 72-293/302.0
QKNYLFLGDYVDRGPYSIEVVLMLFAMHLRWPDRVTLLRGNHESRPVNRQYGFYGECVRRYSE----RIYEVFQLAFNAMPLTAIVNKRIMCMHGGISEE
.. ..|||||||||. ||| . ..||. . .| .  |||||||.. .|  ||| .| . |...    .|.| |. .|  |||.|.| ..|.|.|||||. 
sdkfvflGdyvdrGsksieciclvfalkvlyptnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispk

LFDLKQLDALKRPID-TPDIGIIADLTWADPE---------CEIDYYKESPRGAGKIFGAKAVDEFCKHFQLDLIVRAHQVVQDGYEFFADRKLVTIFSA
|  |.... .|||.    .  .  || .|||           . .| |.  ||   .|   || ..||...|.|||||||..  |. ||||.||.|||||
lesledikkikrplkevtedslaqdllfadpldvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsa

PFYCGQTNNIASMLNIDKDMVA
| |  ...|  ..|..| .   
prymnesdnkGavlkvdtngkl
PPP_2 133-302 5.6e-58 188.9 In-house 23-197 (198) alignment 
Range on Protein: 133-302
Range on HMM: 23-197/198.0
QKTQKNYLFLGDYVDRGPYSIEVVLMLFAMHLRWPDRVTLLRGNHESRPVNRQYGFYGECV-RRYSERIYEVFQLAFNAMPLTAIVNKRIMCMHGGISEE
......||||||||||| .|.||.|.|.|. |..|..|.||||||||. ||. |||. |.. .......|. .|  |...||.|.........|||.|||
psperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfelLplaalidekvlvvHGGlsee

LFDLKQLDALKRPIDTPDIGIIADLT----WADPECEIDYYKESPRGAGKIFGAKAVDEFCKHFQLDLIVRAHQV
.  |.|    .|.|..|. | . ||.    . ||. . . ...| |||| .||.....|......|.||.|||.|
iklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_5_Dcr2 74-303 2.1e-57 187.3 In-house 1-199 (199) alignment 
Range on Protein: 74-303
Range on HMM: 1-199/199.0
VTIVGDIHGQFEDLKMMMDMNGwpF---TedeakemcknlllkggkdgkqtfpavlgsgtdrqktQKNYLFLGDYVDRGPYSIEVVLMLFAMHLRWPDRV
||..||.|||..|| . .  .|  .   .                                    ...|.|||||||||..|.||.|.|.|. |. |..|
vtvcGDlHGqlddlllilfkeg..gdpse....................................erlyvFlGDyVDrGkdslevlllLlalklvypkev

TLLRGNHESRPVNRQYGFYGECVRR-YSERIYEVFQLAFNAMPLTAIVNKRIMCMHGGISEELFDLKQLDALKRPIDTP-DIGIIADLT-WADPECEI-D
.|||||||.. .|. |||. |.... ....||....  |. .||.|.........|||.|.|. ....|....|.|..| . |  |||. |.||. .  .
hllrGNHEdeqlneiygftkevlskyhgkkiykilsdvfdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqeg

YYKESPRGAGKIFGAKAVDEFCKHFQLDLIVRAHQVV
.  .| |||| .|| .....|... .|.||.|.|...
cklnseRGagllfgpdvtekfleknnlkliirshelk
PPP_4 133-302 1.3e-55 181.5 In-house 25-196 (197) alignment 
Range on Protein: 133-302
Range on HMM: 25-196/197.0
QKTQKNYLFLGDYVDRGPYSIEVVLMLFAMHLRWPDRVTLLRGNHESRPVNRQYGFYGECVRRYSERIYEVFQLAFNAMPLTAIVNKRIMCMHGGISEEL
......|.|||||||||..|.||.|.|.|. |. |..|.||||||||. .|. |||. |........|.. .|  |. .||.|.........|||.|.||
pseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvfdllplaalidekvlvvhgglsdel

FDLKQLDALKRPIDTP-DIGIIADLT-WADPECEIDYYKESPRGAGKIFGAKAVDEFCKHFQLDLIVRAHQV
 .|.......|.|..| . . . ||  |.||. . . ...| |||| .||......|... .|.||.|.|..
esldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
subfamily_PPPLV_pd Subfamily PPPLV 135-340 3.7e-47 154.0 In-house 54-278 (290) alignment 
Range on Protein: 135-340
Range on HMM: 54-278/290.0
TQKNYLFLGDYVDRGPYSIEVVLMLFAMHLRWPDRVTLLRGNHESRPVNRQYGFYGECVRRYSER---IYEVFQLAFNAMPLTAIVNKRIMCMHGGISEE
|  ..||||||||||..|.|..  |.|... .| .| ||||||| . |  .. ..||.  .. ..   ..| |. .|.|.||.|.......|.|.|| . 
tpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqesieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipra

LFDLKQ-------LDALKRPIDTPDigIIADLTWADPECEID------------YYKESPRGAGKIFGAKAVDEFCKHFQLDLIVRAHQVVQDGYEFFAD
     .       |. || .||     .  |. |.||. . |            . ... || | .|...|.. | |. .|. ..|||.| . |...  .
imtqayisaiqdilerlkddidgap..laldilwsdpaedrdlslrgelvlneGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqk

RKLVTIFSAPFYCGQTNNIASMLnIDKD
 .|.|.||.  |||..|. | .| .||.
grlltvfsssrycGssneaalil.vdkk
Metallophos Calcineurin-like phosphoesterase 73-303 9.8e-34 110.4 Pfam-A 2-199 (200) alignment 
Range on Protein: 73-303
Range on HMM: 2-199/200.0
PVTIVGDIHGQFEDLKmmmdmngwpftedeakemcknlllkggkdgKqTFPAVLGSGTDRQktQKNYLFLGDYVDRGPYSIEVVLML--FAMHLRWPDRV
.....||.||...||.                              . .. ..|  . . .    ..|||||.||||..|.|.   |  ..  |. |..|
rilvigDlHgglddle..............................d.lllillkiaaeek..pdlvlflGDlvdrgdwssetlalldylvlklllpipv

TLLRGNHESRPVNRQYGFYGECV----------------------------------RRYSERIYEVFQLAFNAMPLTAIVNKRIMCMHGGISEELFDLK
 ||||||||.|.|  |||. |.                                    ..  ...| ..  |.|.|| |.|...| ..||..|...    
fllrGNHesdpgnsaygflleqlkdlrglangeeeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgd

QLdalkrpidtpdigiiadltwadpeceidyykesprgAGKIFGAKAVDEFCKHFQLDLIVRAHQVV
.                                     ..  || .|......  ..||..|.|. .
di....................................gselfgpdalekllekygvdlvlrGHtHk
subfamily_PPP7C_pd Subfamily PPP7C 135-243 1.8e-28 92.4 In-house 91-201 (383) alignment 
Range on Protein: 135-243
Range on HMM: 91-201/383.0
TQKNYLFLGDYVDRGPYSIEVVLMLFAMHLRWPDRVTLLRGNHESRPVNRQYGFYGECVRRY---SERIYEVFQLAFNAMPLTAIVNKRIMCMHGGISEE
....|.| ||.||||  |.|..|.|.|. | .|  | | |||||   .| .|||  |   .|   ...| ....  |  .||.......|. .|||||..
eenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdk

lFDLKQLDALKR
  ||. || ..|
.tdlelldkier
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 39-119 3.3e-21 68.7 In-house 5-84 (339) alignment 
Range on Protein: 39-119
Range on HMM: 5-84/339.0
VNCQDMLKRYEIYELCLRARELFWTQPLYRHVEVPVTIVGDIHGQFEDLKMMMDMNGWPFTEDEAkEMCKNLLLKGGKDGK
  . |..   |. ||| ||||| |..|.. ..| |. ..|||||||.||  |.||||||.. .|  |  |.. ..  . ||
ktsldlfcaaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmngwplssqef.ealkditvrsretgk
subfamily_PPP7C_pd Subfamily PPP7C 253-346 6.4e-18 57.6 In-house 237-330 (383) alignment 
Range on Protein: 253-346
Range on HMM: 237-330/383.0
IADLTWADPECEIDYYKESPRGAGKIFGAKAVDEFCKHFQLDLIVRAHQVVQDGYEFFADRKLVTIFSAPFYCGQTNNIASMLNIDKDMVASFM
. |. |.||. .     .. ||.|  ||.   ... ....|.|..|.|.  ..||||  |.|..|||||  |  .  |  . ... ||.   ..
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltpriv
PPP_3 45-97 6.6e-12 38.0 In-house 2-53 (271) alignment 
Range on Protein: 45-97
Range on HMM: 2-53/271.0
LKRYEIYELCLRARELFWTQPLYRHVEVPVTIVGDIHGQFEDLkMMMDMNGWP
|.  |..||. ...|.. ...   ... |||..||||||..|| . .  || |
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDL.lelfknggp
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 40-99 5.6e-11 35.0 In-house 19-78 (298) alignment 
Range on Protein: 40-99
Range on HMM: 19-78/298.0
NCQDMLKRYEIYELCLRARELFWTQPLYRHVEVPVTIVGDIHGQFEDLKMMMDMNGWPFT
.   ..|  .. .|.  |...| .|.    |. |... ||||||. ||  ..| .|.| .
kltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppd
subfamily_PPZ_pd Subfamily PPZ 44-98 5.7e-11 35.5 In-house 24-78 (300) alignment 
Range on Protein: 44-98
Range on HMM: 24-78/300.0
MLKRYEIYELCLRARELFWTQPLYRHVEVPVTIVGDIHGQFEDLKMMMDMNGWPF
 ||  || ..| .||||| .||    .  .| ||||.|||. ||  ..   |.| 
clknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfpp
PPP_1 47-96 6.6e-11 35.0 In-house 3-51 (264) alignment 
Range on Protein: 47-96
Range on HMM: 3-51/264.0
RYEIYELCLRARELFWTQPLYRHVEVPVTIVGDIHGQFEDLkMMMDMNGW
. |..||. ...||. ...   .|. ..|..|||||||.|| . .  .| 
eeelaelkkklkellnkeenllevseeitvcGDiHGqfdDL.lklfkvgg
subfamily_PPP4C_pd Subfamily PPP4C 43-95 7.2e-11 34.8 In-house 14-66 (288) alignment 
Range on Protein: 43-95
Range on HMM: 14-66/288.0
DMLKRYEIYELCLRARELFWTQPLYRHVEVPVTIVGDIHGQFEDLKMMMDMNG
...|  |. .|| .|||..  .   ..|. |||. |||||||.||. .....|
elikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvgg
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 44-98 1.3e-09 30.7 In-house 23-77 (299) alignment 
Range on Protein: 44-98
Range on HMM: 23-77/299.0
MLKRYEIYELCLRARELFWTQPLYRHVEVPVTIVGDIHGQFEDLKMMMDMNGWPF
 .|  |. .||  |.. |  |.    || |. ..||||||. ||  ..|..|.| 
svkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfpp
subfamily_PPP2C_pd Subfamily PPP2C 43-95 1.4e-09 30.6 In-house 15-67 (290) alignment 
Range on Protein: 43-95
Range on HMM: 15-67/290.0
DMLKRYEIYELCLRARELFWTQPLYRHVEVPVTIVGDIHGQFEDLKMMMDMNG
. |.  |. ||| .|.|.. ..   ..|..|||..||.|||| ||  .. . |
kqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkigg
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 50-99 1.7e-09 30.5 In-house 8-57 (284) alignment 
Range on Protein: 50-99
Range on HMM: 8-57/284.0
IYELCLRARELFWTQPLYRHVEVPVTIVGDIHGQFEDLKMMMDMNGWPFT
.  | ..| ..|  ||.   |. |. |.||||||| ||  ..| ||.|  
vetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphr
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 42-93 5.9e-09 28.5 In-house 3-54 (302) alignment 
Range on Protein: 42-93
Range on HMM: 3-54/302.0
QDMLKRYEIYELCLRARELFWTQPLYRHVEVPVTIVGDIHGQFEDLKMMMDM
.. ....|.. |.    ||. ..    ..  |||||||||||||||  .. .
kkeysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilna
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 42-93 6.3e-09 28.4 In-house 4-55 (302) alignment 
Range on Protein: 42-93
Range on HMM: 4-55/302.0
QDMLKRYEIYELCLRARELFWTQPLYRHVEVPVTIVGDIHGQFEDLKMMMDM
.. ....|.. |.    ||. ..    ..  |||||||||||||||  .. .
kkeysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilna
subfamily_PPP6C_pd Subfamily PPP6C 41-95 7.1e-08 24.9 In-house 12-65 (290) alignment 
Range on Protein: 41-95
Range on HMM: 12-65/290.0
CQdMLKRYEIYELCLRARELFWTQPLYRHVEVPVTIVGDIHGQFEDLKMMMDMNG
|. .|   .. .|| .  .|.  .   . |. |||..||||||| ||. ..   |
ck.ylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtgg
subfamily_PPG1_pd Subfamily PPG1 43-95 9.8e-08 24.6 In-house 12-64 (300) alignment 
Range on Protein: 43-95
Range on HMM: 12-64/300.0
DMLKRYEIYELCLRARELFWTQPLYRHVEVPVTIVGDIHGQFEDLKMMMDMNG
..|    . ||. . .||. ..    ... |||.|||.|||| |.  .... |
ellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkigg
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 43-97 1.2e-07 24.0 In-house 14-68 (290) alignment 
Range on Protein: 43-97
Range on HMM: 14-68/290.0
DMLKRYEIYELCLRARELFWTQPLYRHVEVPVTIVGDIHGQFEDLKMMMDMNGWP
| ..  .|.|.  ...|..   |   .|| |..||||||||...|  ..|  | |
dafsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyp
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 43-97 2.5e-07 22.9 In-house 8-62 (287) alignment 
Range on Protein: 43-97
Range on HMM: 8-62/287.0
DMLKRYEIYELCLRARELFWTQPLYRHVEVPVTIVGDIHGQFEDLKMMMDMNGWP
| ..  .|.|.  ...|..   |   .|| |.|||||||||..||  ...  | .
dafsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaa
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 55-100 7e-07 21.8 In-house 33-78 (297) alignment 
Range on Protein: 55-100
Range on HMM: 33-78/297.0
LRARELFWTQPLYRHVEVPVTIVGDIHGQFEDLKMMMDMNGWPFTE
  | ..| .|     |. |. ..||||||| ||  ..   ||| | 
dlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwppta
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 45-97 2.5e-06 19.9 In-house 6-58 (280) alignment 
Range on Protein: 45-97
Range on HMM: 6-58/280.0
LKRYEIYELCLRARELFWTQPLYRHVEVPVTIVGDIHGQFEDLKMMMDMNGWP
.|  .|...  . .... .|     |. ||...||.|||. ||  ...  ..|
ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfp
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 45-96 3.6e-06 19.4 In-house 8-59 (281) alignment 
Range on Protein: 45-96
Range on HMM: 8-59/281.0
LKRYEIYELCLRARELFWTQPLYRHVEVPVTIVGDIHGQFEDLKMMMDMNGW
. . || ..   .. .|  .     .. |...|||.|.||.||| .... | 
ytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgr
PPP_2 74-98 6.2e-06 19.0 In-house 1-24 (198) alignment 
Range on Protein: 74-98
Range on HMM: 1-24/198.0
VTIVGDIHGQFEDLkMMMDMNGWPF
||..||.|||..|| . .  || | 
vtvcGDlHGqldDL.lilfknglps