Gene F26B1.5 in Caenorhabditis elegans

Synonym: CELE_F26B1.5, F26B1.5

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily CelePPP-sf5
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP071_AA protein Get Run
CeleP071_AA_7-340 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 26-339 2.1e-170 558.7 In-house 1-301 (302) alignment 
Range on Protein: 26-339
Range on HMM: 1-301/302.0
YRQHVYEKSDLLLLIGQIMELFKMEKTLATISPPVTIVGDIHGQYPDLVRILNSRISKEEAKQKIVTSYSSNRFVFLGDYVDRGNHSIECICLVFALKVL
||...|.||.||||| ...||.|.|||||.||||||||||||||..|||||||.|.||||||.|...|.||..|||||||||||..||||||||||||||
yrkkeysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvl

dlkfvsllvimfqiaYPTNFVLLRGNHETKAINFAYGFREELENRLGKKDGFEIWEKFNEVFSFMPLACLVGGRILCMHGGISEKLESLDSIDSIVRPLP
               ||||..||||||||||||||||||||||||||||||.||||||||||||||||.||| .|||.|||||.|||||..|..|.|||.
...............yptnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplk

EVTD--LAQDLLWSDPMDVQTLASISDTPKYAKNIVRGLAHSFNDAAVRDVCRRLNLHLVVRAHQMIPEGFKFNSDRKLLTIFSAPRYMNESDNRGATLQ
|||.  ||||||..||.|||.||..|..|||||||||||...||.|||||||.||||.|.|||||||||||||..|.|||||||||||||||||.||.|.
evtedslaqdllfadpldvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlk

VDVNGQLSISVMRYTK
||.||.|||||.|..|
vdtngklsisvlrnkk
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 25-339 7.5e-170 556.8 In-house 1-302 (302) alignment 
Range on Protein: 25-339
Range on HMM: 1-302/302.0
NYRQHVYEKSDLLLLIGQIMELFKMEKTLATISPPVTIVGDIHGQYPDLVRILNSRISKEEAKQKIVTSYSSNRFVFLGDYVDRGNHSIECICLVFALKV
.||...|.||.||||| ...||.|.|||||.||||||||||||||..|||||||.|.||||||.|...|.||..|||||||||||..|||||||||||||
kyrkkeysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkv

LdlkfvsllvimfqiaYPTNFVLLRGNHETKAINFAYGFREELENRLGKKDGFEIWEKFNEVFSFMPLACLVGGRILCMHGGISEKLESLDSIDSIVRPL
|               ||||..||||||||||||||||||||||||||||||.||||||||||||||||.||| .|||.|||||.|||||..|..|.|||
l...............yptnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrpl

PEVTD--LAQDLLWSDPMDVQTLASISDTPKYAKNIVRGLAHSFNDAAVRDVCRRLNLHLVVRAHQMIPEGFKFNSDRKLLTIFSAPRYMNESDNRGATL
.|||.  ||||||..||.|||.||..|..|||||||||||...||.|||||||.||||.|.|||||||||||||..|.|||||||||||||||||.||.|
kevtedslaqdllfadpldvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavl

QVDVNGQLSISVMRYTK
.||.||.|||||.|..|
kvdtngklsisvlrnkk
PP2Ac_SM00156 32-336 2.1e-91 298.7 In-house 2-268 (271) alignment 
Range on Protein: 32-336
Range on HMM: 2-268/271.0
EKSDLLLLIGQIMELFKMEKTLATISPPVTIVGDIHGQYPDLVRILnsriskeeakqKIVTSYSSNRFVFLGDYVDRGNHSIECICLVFALKvldlkfvs
.|...| |. .. |..| ||.|  .|.|||.|||||||. ||.|.|           .     .....|||||||||| .|||.|.|.||||        
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrll...........elageppeekyvFlGdYVDRGpqsiEvillLfalk........

llvimfqIAYPTNFVLLRGNHETKAINFAYGFREELENRLgkkdGFEIWEKFNEVFSFMPLACLVGGRILCMHGGISEKLESLDSIDSIVRPLPE-VTDL
       |.||...||||||||.. .|..|||.||....     | ||.|||.|.|| .|||.||. .|||||||.|..|||||.|... |.  .    |
.......ilypekvvLLRGnHEsssvnkiygfeeevkrky....gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegl

AQDLLWSDPmdvqtlasISDTPKYAKNIvRGLAHSFNDAAVRDVCRRLNLHLVVRAHQMIPEGFKFNSDRKLLTIFSAPRYMNESDNRGATLQVDVNGQL
. |||||||         .......... ||| . |. .||.......||.|..|||....||..|..|.||.||||||.|..|..| .|.|.|. | .|
lidllwsdp........eqkekgfqpsk.rglsvvFgedavkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlkl

SISVMR
|| ...
sieqlk
0045823 Metallo-dependent phosphatases 8-340 1e-82 271.3 In-house 27-326 (473) alignment 
Range on Protein: 8-340
Range on HMM: 27-326/473.0
LDIHQFIKSHLfvknwinYRQHVYEKSDLLLLIGQIMELFKMEKTLATISPPVTIVGDIHGQYPDLVRILNsRISkeeA---KqkivtsyssnRFVFLGD
| .......||       ... .....||| |. ...|..| |..|  .|......||||||. || |.|. .|                   |.|||||
lldldlliehl.......kkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrlle.kig...fpped..........rlvflGD

YVDRGNHSIECICLVFALkvldlkfvsllvimfQIAYPTNFVLLRGNHETKAINFAYGFREELENRLGKKdgfeIWEKFNEVFSFMPLACLVGGRILCMH
.|||| .|.|...|..||               .|.||.|..|||||||....|..|||..|.  ..| .    ..| |.|... .|||...||.||..|
lvDrGpdslevlelllal...............kikypgnvfllrGNHElrllnglygfgdetlekyged....lyeeflewlrslPlaaviggkilfvH

GGISEKLESLDSIDSIVRPLpEVT--DLAQDLLWSDPmDVQTLASISDTPKYAKNIvRGLAHSFNDAAVRDVCRRLNLHLVVRAHQMIPEGFKFNSDRK-
||.|  |..|| |..| ||| |.   .|. ||||||| . . . ...... .  .  ||  . |.  ||...... .| |.||.|.. |||...  |.| 
GGlspdlplldqireierpl.eipddgllldllwsdP.weddgdgllrlrffgnsp.rgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkv

-----LLTIFSAPRYMNESDNRGATLQVDVNGqLSISVMRYTKP
     ..|.|||| |... .|..| |..| .. .|. ...... 
igiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsph
subfamily_PPP1C_pd Subfamily PPP1C 30-337 2.4e-79 259.5 In-house 9-278 (282) alignment 
Range on Protein: 30-337
Range on HMM: 9-278/282.0
VYEKSDLLLLIGQIMELFKMEKTLATISPPVTIVGDIHGQYPDLVRILNSRISKEEAkqkivtsyssnRFVFLGDYVDRGNHSIECICLVFALKvldlkf
  .....  |. .  |... . .| ... ||.||||||||| ||.|....  . .|.           ...|||||||||..|.| |.|..|.|      
klkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpes...........nylflGdyvdrGkqsletivlllayk......

vsllvimfqIAYPTNFVLLRGNHETKAINFAYGFREELENRLGKKdgfeIWEKFNEVFSFMPLACLVGGRILCMHGGISEKLESLDSIDSIVRPLPE-VT
         | ||.|. |||||||.. ||  ||| .| ..|...|    .|..|..||...||| ||  .|||.|||.|..|.||. |..| |||    .
.........ikypenlfllrGnhesasinriyGfydeckrrysik....lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpek

DLAQDLLWSDPmDVQTLasisdtpKYAKNIvRGLAHSFNDAAVRDVCRRLNLHLVVRAHQMIPEGFKFNSDRKLLTIFSAPRYMNESDNRGATLQVDVNG
 |. ||||||| | ..|       ....|  ||  ..|.. .|...... .|.|.|||||.. .|..| ..|.|.|.|||| |..| || || |.|| . 
gllcdllWsdp.dkevl.......gwsend.rGvsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeel

QLSISVMRY
 .| .... 
lvsfqilkp
0049330 Metallo-dependent phosphatases 15-339 5e-76 248.8 In-house 14-300 (309) alignment 
Range on Protein: 15-339
Range on HMM: 14-300/309.0
KSHLFVKNWINYRQHVYEKSDLLLLIGQIMELFKMEKTLATISPPVTIVGDIHGQYPDLVRILNsRISKEeakqkivtsySSNRFVFLGDYVDRGNHSIE
.|.| .   . ..........||||. ...|..| |..|  .| .....||||||. || |.|. .|             ...|.|||||.|||| .|.|
lslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrlle.kigfp..........pedrlvflGDlvdrGpdsle

CICLVFALkvldlkfvsllvimfQIAYPTNFVLLRGNHETKAINFAYGFREELENRLGKKdgfeIWEKFNEVFSFMPLACLVGGRILCMHGGISEKLESL
...|..||               ...|| |..|||||||. ..|..|||..|.  ..| .    .||.|..... .|||...||.|||.|||.|  | .|
vlllllal...............kllypdnvfllrGNHElrllnglygfgdetlrkygae....lweefldwlrslplaaviggkilcvHgGlspdllll

DSIDSIVRPLP-EVTDLAQDLLWSDPMDVQTLasisdtpkYAKNIvRGLAHSFNDAAVRDVCRRLNLHLVVRAHQMIPEGFKFNSDRKLLTIFSAPRYMN
|.|... |||    ..|  |||||||...           .|.|. ||| . |.  ||........|.|..|.|.. ..|...  |.||.|.||||.|..
dqirelerpleipldgllcdllwsdplpireg........fapnp.rglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycg

ESDNRGATLQVDVNGQLSISVMRYTK
. .|.|| |..| .. .|. ......
rlgnlgavleidedlvisfllfepvp
0053225 Metallo-dependent phosphatases 26-335 9.8e-72 234.8 In-house 17-288 (293) alignment 
Range on Protein: 26-335
Range on HMM: 17-288/293.0
YRQHVYEKSDLLLLIGQIMELFKMEKTLATISPPVTIVGDIHGQYPDLVRILNsRISKEeakqkivtsySSNRFVFLGDYVDRGNHSIECICLVFALKvl
... .. ...||||. ...|..| |..|  .| .....|||||.. || ..|. .|             ...|.|||||.|||| .|.|...|..|||  
lllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlalle.kigfp..........pedrlvflGDlvdrGpdslevlelllalk..

dlkfvsllvimfqIAYPTNFVLLRGNHETKAINFAYGFREELENRLGkkdGFEIWEKFNEVFSFMPLACLVGGRILCMHGGISEKLESLDSIDSIVRPLP
             . ||.|.||||||||.. .|..|||..|   ..|   ..|.|. ...... .|||.|.||.||..|||.|  | .||.|..| ||| 
.............llypdnvvllrGNHElmllnglygfgdetlrkyg...aaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplr

-EVTDLAQDLLWSDPmdvqtlasiSDTPKYAKNIvRGLAHSFNDAAVRDVCRRLNLHLVVRAHQMIPEGFKFNSDRKLLTIFSAPRYMNESDNRGATLQV
 . ..|  |||||||         ..  ...... ||| . |.  ||...... .|.|..|.||. |.|...  |.||.|.||||.|... .|.|| | .
iplegllldllwsdp.........dlwsgwlpsy.rglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlal

DVNGQLSISVM
| .   .. ..
deglvwgfklf
PPP_1 34-323 6.3e-68 221.9 In-house 4-263 (264) alignment 
Range on Protein: 34-323
Range on HMM: 4-263/264.0
SDLLLLIGQIMELFKMEKTLATISPPVTIVGDIHGQYPDLVRILnsriskeeakqKIVTSYSSNRFVFLGDYVDRGNHSIECICLVFALKvldlkfvsll
. |  |. .  ||.. |..| ..| ..|..||||||. ||...            |.  . ......|||||||||..|.|...|..|||          
eelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklf...........kvggpspetnYlFlGDyVDRGkdSvEilllLlalk..........

vimfqIAYPTNFVLLRGNHETKAINFAYGFREELEnrlGKKDGFEIWEKFNEVFSFMPLACLVGGRILCMHGGISEKLESLDSIDSIVRPLPEVT-DLAQ
     . || .. |||||||.. ..  |||..|.     || . ||.. . .|| ..|||.|. ..||..|||.|..|..||.|  . |    ..   ..
.....lkypkelfllRGNHEsrqvtkvygFkkEvl...kkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklc

DLLWSDPMdvQTLASISDTPKYAKNIVRGLAHSFNDAAVRDVCRRLNLHLVVRAHQMIPEGFKFNSDRKLLTIFSAPRYMNESDNRGATLQ
|||..|    ..| . ... .  .| .|| .. |.  ........ ||.|..|||.. .||..| ..||..|||||. |..| .|||| ..
dllekdvd..illsddkeqeeavansiRGagylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 28-336 1.8e-66 217.5 In-house 5-281 (284) alignment 
Range on Protein: 28-336
Range on HMM: 5-281/284.0
QHVYEKSDLLLLIGQIMELFKMEKTLATISPPVTIVGDIHGQYPDLVRILNSRISK---EEAKQkivtsyssNRFVFLGDYVDRGNHSIECICLVFAlkv
|..... .|. |  .  |||  ||    |  ||.||||||||. ||. .|.        .|||.        ....||||||||| .||| | |.||   
qkllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeake........kkylflgdyvdrgpfsievitllfa...

ldlkfvsllvimFQIAYPTNFVLLRGNHETKAINFAYGFREELENRLGKKdgfeIWEKFNEVFSFMPLACLVGGRILCMHGGISEKLESLDSIDSIVRPL
            ... .| . .|||||||.. .|  ||| .| ..|  ..    ..| |.  |  |||...|. .|.||||||||.| .|. .| . ||.
............yklllpdkvfllrgnhesrpvnmqygfyleckkrysea....lyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpi

pEVTD--LAQDLLWSDPMdvQTLAsisdtpKYaKNIVRGLAHSFNDAAVRDVCRRLNLHLVVRAHQMIPEGFKFNSDRKLLTIFSAPRYMNESDNRGATL
 ...|  .  || |.||   ...       .| |.  ||  ..| ..||.. ... .|.|||||||.. .|..| .||||.|||||| |  . || .| |
.dipdigviadltwadpe..aeve......gy.kesprgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavl

QVDVNGQLSISVMR
.|| .   |..|..
nvdeelvasftvlk
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 35-338 1.2e-65 214.7 In-house 28-294 (299) alignment 
Range on Protein: 35-338
Range on HMM: 28-294/299.0
DLLLLIGQIMELFKMEKTLATISPPVTIVGDIHGQYPDLVRILNsriskeeaKQKIVtsySSNRFVFLGDYVDRGNHSIECICLVFAlkvldlkfvsllv
.|  |     . |  . .|  . .|. ..||||||| ||.||..        |...        |.|||||||||   .| |.|...             
elqtlcavaksvfasqaslleveapiivcgdihgqysdllrifd........kagfp...pdvnflflgdyvdrgrqnlelitlllc.............

imFQIAYPTNFVLLRGNHETKAINFAYGFREELENRLgkkDGFEIWEKFNEVFSFMPLACLVGGRILCMHGGISEKLESLDSIDSIVRPL-PEVTDLAQD
  |.| || .| .||||||  |||  ||| || ..|        .|  |.. |..|||. |.|.||||||||.| ||..|| .  . ||  |    |  |
..fkikyperffmlrgnhecpainrvygfyeecnkry...kstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgid

LLWSDPMDvqtlaSISDtpkYAKNiVRGLAHSFNDAAVRDVCRRLNLHLVVRAHQMIPEGFKFNSDRKLLTIFSAPRYMNESDNRGATLQVDVNGQLSIS
|||.|| .     |. |   .  | |||... | .  |.||. ||.. || ||||.. .|..| ...||.|||||| |  . ||  |...|| |   .. 
llwadpdq.....svkd...wlan.vrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfv

VMRYT
|.. |
vlkpt
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 30-334 8.7e-63 205.2 In-house 7-273 (281) alignment 
Range on Protein: 30-334
Range on HMM: 7-273/281.0
VYEKSDLLLLIGQIMELFKMEKTLATISPPVTIVGDIHGQYPDLVRILNsriskeeakqkIVTSYSSNRFVFLGDYVDRGNHSIECICLVFALKvldlkf
 | | ..  .| ..  .|  ||.|. | .|...|||.|.|. || |...           ..   . ...|||||||||| .|.|.. |.|.||      
qytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfe...........llgrvpeevlvflgdyvdrgpqslevlillftlk......

vsllvimfqIAYPTNFVLLRGNHETKAINFAYGFREELENrlgkKDGFEIWEKFNEVFSFMPLACLVGGRILCMHGGISEKLESLDSIDSIVRPLPE-VT
         |.|. . ||||||||. ..|  ||| .|       | | |.| .|.. |  .|.. |.  |.||||||.| .| .|| .  . .|. .   
.........iryrdrivllrgnheiasvnkiygfyvecvt....kyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldr

DLAQDLLWSDPMDVQTlasisdtpKyAKNIVRGLAHSFNDAAVRDVCRRLNLHLVVRAHQMIPEGFKFNSDRKLLTIFSAPRYMNESDNRGATLQVDVNG
 |  ||||.|| .           .  |. .|| .. |  . | |||.||.. |..||||.. .|..  | |||.|.||.| | .   | .| |.|| . 
GlviDllwadpdnkve........e.wkassrGssftfGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetl

QLSISV
..|.  
gislva
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 55-334 3.8e-62 203.3 In-house 4-250 (263) alignment 
Range on Protein: 55-334
Range on HMM: 4-250/263.0
TISPPVTIVGDIHGQYPDLVRILNSRiskeEAKQKivtsyssNRFVFLGDYVDRGNHSIECICLVFALKvldlkfvsllvimfqIAYPTNFVLLRGNHET
 .  |. |.|| |||| ||.||.|.      |  |        ...||||||||| ||.| | |.|.||               .| | .. ||||||| 
elqapinicgdthgqyndllrifnac....gaatk.......tqylflgdyvdrgghslevimllfslk...............lamprkmhllrgnhel

KAINFAYGFREELENRLGKKDGFE-IWEKFNEVFSFMPLACLVGGRILCMHGGISEKLESLDSIDSIVRPLPE--VTDLAQDLLWSDPMDvqtlasisDT
||||  |||. ||..|. ... .| ....||.|||.|||...|  |||||||||| .|.||| | .|  ||       || ||||.||          |.
kainknygfhaelkkrfqreevyesvynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpek........da

PKYAKNIVRGLAHSFNDAAVRDVCRRLNLHLVVRAHQMIPEGFKFNSDRKLLTIFSAPRYMNESDNRGATLQvdVNGQLSISV
  .  | .| ..  |    | |.|.||.. |.|||||..  |. | .||.|.|.||| ||  |  |  | .   ||  | .|.
kgfepnkiraisnvfgkkevddlckrldidlivrahqvveygyaffadrrlitvfsasryqielcnyaavvv..vnkmlelsf
subfamily_PPP3C_pd Subfamily PPP3C 29-327 4.7e-62 203.2 In-house 39-312 (452) alignment 
Range on Protein: 29-327
Range on HMM: 39-312/452.0
HVYEKSDLLLLIGQIMELFKMEKTLATISPPVTIVGDIHGQYPDLVRILNsriskeeakqkIVTSYSSNRFVFLGDYVDRGNHSIECICLVFALKvldlk
   |... | .| .  .|.| |||| ... |.|..||||||. ||.....           .  . .| ...||||||||| .||||.  ..|||     
grleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfe...........vgGdPastkylflGdyvdrGyfsiecvlylyalk.....

fvsllvimfqIAYPTNFVLLRGNHETKAINFAYGFREELENrlgkKDGFEIWEKFNEVFSFMPLACLVGGRILCMHGGISEKLESLDSIDSIVRP-LPEV
          ||||... |||||||.. .   . |.||..     | . |..... | |  .||| |. .. ||.|||.| ...|||.|... |   |. 
..........iaypstlfllrGnhecrhlteyftfkeecki....kyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppa

TDLAQDLLWSDPMdvQTLASISDTPKYAKNIVRGLAHSFNDAAVRDVCRRLNLHLVVRAHQMIPEGFKFNSD------RKLLTIFSAPRYMNESDNRGAT
. .  |||||||.  .   . . . |. .| ||| .. .. .|| .  .. .|  ..|||.   .|.. . .        |.|.|||| |..  .|..| 
sGplcdllWsdPl..edygeekteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaav

LQVDVN
|... |
lkyenn
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 132-338 7.6e-62 202.0 In-house 99-294 (298) alignment 
Range on Protein: 132-338
Range on HMM: 99-294/298.0
LLVIMFQIAYPTNFVLLRGNHETKAINFAYGFREELENRLGKKDgfeIWEKFNEVFSFMPLACLVGGRILCMHGGISEKLESLDSIDSIVRPLPEVT-DL
.|.. ... ||.||.|||||||..|||  ||| || ..|  .     ....|..||. .||..|.||||||||||.|.||.|||.. .. ||  .    |
vlllaykvkypnnffllrGnheceainrvyGfyeeckrrykslr...lyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeesl

AQDLLWSDPMDVQTlasisdtpKYAKNiVRGLAHSFNDAAVRDVCRRLNLHLVVRAHQMIPEGFKFNSDRKLLTIFSAPRYMNESDNRGATLQVDVNGQL
| ||||.|| ....         .|.|  || .  | . .|.|.. .|.. |||||||.. .|..| ...||.||||||.|... ||  |...|| . ..
aidllwadpenavk........gwaen.srGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvv

SISVMRYT
|  |.. .
sfevlkpe
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 35-340 3.3e-61 200.2 In-house 7-276 (284) alignment 
Range on Protein: 35-340
Range on HMM: 7-276/284.0
DLLLLIGQIMELFKMEKTLATISPPVTIVGDIHGQYPDLVRILNsrisKEEakqkivTSYSSNrFVFLGDYVDRGNHSIECICLVFALKVLdlkfvsllv
|.  |. . ...|. .  |  .  |. |.||||||. ||.|...    |.         . .| ..|||||||||.| .| | |.|| ||.         
dvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfd....kng......fphran.ylflgdyvdrgkhcletilllfaykvi.........

imfqiaYPTNFVLLRGNHETKAINFAYGFREELENRLGKKdgfEIWEKFNEVFSFMPLACLVGGRILCMHGGISEKLESLDSIDSIVRPL--PEVTDLAQ
      .|  |..||||||   ||  ||| || . |  |     ..  |. ||| |||..||| ||||||||.|. |. .  . .| ||.  ||   || 
......fpnhffmlrgnhecslinkiygfyeecqrrynkp...svyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlai

DLLWSDPMDVQtlasisdtpK-YAKNiVRGLAHSFNDAAVRDVCRRLNLHLVVRAHQMIPEGFKFNSDRKLLTIFSAPRYMNESDNRGATLQVDVNGQLS
|.||||| ..|         | .  |  ||... |   |.| .  ||.. |||||||.. .|..| ..|.|.|||||| |  . ||  | . |. |   |
dilwsdptnfq.........kgwnpn.srgvsyvfgsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcs

ISVMRYTKP
. |.|  | 
fvvlrprkk
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 31-337 6.7e-60 195.6 In-house 16-288 (290) alignment 
Range on Protein: 31-337
Range on HMM: 16-288/290.0
YEKSDLLLLIGQIMELFKMEKTLATISPPVTIVGDIHGQYPDLVRILNSriskeeakqkiVTSYSSNRFVFLGDYVDRGNHSIEciclvfalkvldlkfV
.. .|.| .. .| |...   .|  .  |..||||||||  .|.| ...           |      .|.||||||||| .|.|               |
fsdkdileilekieeileplpalleveapivivgdihgqldallryfda...........vgyppkvkflflgdyvdrgaksle...............v

SLLVIMFQIAYPTNFVLLRGNHETKAINFAYGFREELEnrlgKKDGFEIWEKFNEVFSFMPLACLVGGRILCMHGGISEKLESLDSIDSIVRPLPEVT--
|||.. ..| |. .  |||||||.. .|  |||.|||     .| | ..| ....||. ..| . || .|||||||||.|.|| .|. .. .|  ..|  
slllfcykiryskkvhllrgnhevrkvnrlygfkeela....rkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcd

-DLAQDLLWSDPMDVQtlasiSDTpkYAKNIVRGLAHSFNDAAVRDVCRRLNLHLVVRAHQMIPEGFKFNSDRKLLTIFSAPRYMNESDNRGATLQVDVN
  |  ||||.||   .     .||  .| |  |...  | . .. |....| |.|.||||..  |||.|. |.||.|.|||| |  .  | || ..|   
eglqvdllwadptrdk.....ddt..ialnkqraisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvses

GQLSISVMRY
 .||| |.. 
lelsivvlkp
subfamily_PPZ_pd Subfamily PPZ 31-326 6e-58 189.7 In-house 25-282 (300) alignment 
Range on Protein: 31-326
Range on HMM: 25-282/300.0
YEKSDLLLLIGQIMELFKMEKTLATISPPVTIVGDIHGQYPDLVRILNsriskeeakqKIVTSYSSNrFVFLGDYVDRGNHSIECIclvfalkvldlkfv
 ..|..| .  .  |||  . .|  .||.| ||||.|||| ||.|..           |     |.| ..|||||||||..|.| |              
lknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlft..........kcgfppsan.ylflgdyvdrgkqsleti..............

sLLVIMFQIAYPTNFVLLRGNHETKAINFAYGFREELENRLGKKdgfeIWEKFNEVFSFMPLACLVGGRILCMHGGISEKLESLDSIDSIVRPLpEVTD-
 ||.. ..| || ||.|||||||   .   ||| .| . |   |    ||. | . |  .|||..| |.|.|.|||.|  |.|.| |  .|||  .| | 
.llllcykikypenffllrgnhecanvtrvygfydeckrrcnik....iwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrpt.dvpdf

-LAQDLLWSDPMDvqtlasisdTPKYAKNIVRGLAHSFNDAAVRDVCRRLNLHLVVRAHQMIPEGFKFNSDRKLLTIFSAPRYMNESDNRGATLQVDV
 | .||||||| |         ...  ..  ||... .|  |.  .  .. . ||.||| .. .|..|  || |.|.|||| |  | || || . |  
glindllwsdptd.........ssnewednergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvse
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 32-338 5.2e-57 186.4 In-house 24-295 (297) alignment 
Range on Protein: 32-338
Range on HMM: 24-295/297.0
EKSDLLLLIGQIMELFKMEKTLATISPPVTIVGDIHGQYPDLVRILNSRiskeeakqkivTSYSSNRFVFLGDYVDRGNHSIECICLVFALKVldlkfvs
 .  .| |.   ...|| .|..  .  |. ..||||||.|||.|..                  .  ..|||||||||  ||| | |..| ||       
teervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrg...........gwpptanylflgdyvdrgrfsietivlllaykv.......

llvimfqiAYPTNFVLLRGNHETKAINFAYGFREELENRLgkkDGFEIWEKFNEVFSFMPLACLVGGRILCMHGGISE---KLESLDSIDSIVRPLPEVT
         .|.|..||||||| . .| .||| || ..|    .   ..  |..|| ..||. |.  .|||||||.|    |  .||..  | |.     
........kfpgnlfllrgnhecefvnkvygfyeecqkry...qsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierstegke

DLAQDLLWSDPmdvqtlasISDTPKYAKNiVRGLAHSFNDAAVRDVCRRLNLHLVVRAHQMIPEGFKFNSDRKLLTIFSAPRYMNESDNRGATLQVDVNG
 |  ||||.||        ||    . .|  ||    |   || ..|  ..| ||.||||.. .|..| . |||.||||||.|  . ||  | . .| . 
rlvadllwadp........isglsgfmen.qrgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdekl

QLSISVMRYT
| |. ..| |
qcsfeilrpt
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 130-337 2e-56 184.0 In-house 83-281 (287) alignment 
Range on Protein: 130-337
Range on HMM: 83-281/287.0
VSLLVIMFQIAYPTNFVLLRGNHETKAINFAYGFREELENRLGkkdgFEIWEKFNEVFSFMPLACLVGGRILCMHGGISEKLESLDSIDSIVRPLPEVTD
||||.  ..|||| .  ||||||| |.||  |||.|||... .     .....||.||| .||   |. ||||||||||.||.||||. .. .|  ... 
vslllfslkiaypkkvhllrGnhevkkinklyGfkeelkrkrq....erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplac

---LAQDLLWSDPMDvqtlasisDTPKYAKNIVRGLAHSFNDAAVRDVCRRLNLHLVVRAHQMIPEGFKFNSDRKLLTIFSAPRYMNESDNRGATLQVDV
   |  ||||.||          |.  .. | .|...  | .  | |....|.. |.||||..  ||..|  |..|.|.||||.|. |  | || ..|. 
deglqvdllwadpek........daktfelnkiraisvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvsk

NGQLSISVMRY
  .||. |.. 
slelsfvvlkp
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 130-336 3e-55 180.3 In-house 79-273 (280) alignment 
Range on Protein: 130-336
Range on HMM: 79-273/280.0
VSLLVIMFQIAYPTNFVLLRGNHETKAINFAYGFREELENRlgkkDGFEIWEKFNEVFSFMPLACLVGGRILCMHGGISEKLESLDSIDSIVRPL-PEVT
| ||.. ... || ||..||||||.  ||  |||..|  .|       .....|.|..  .||..||.|||||||||.|.|| ||| .  ..||. .|  
villllaykvrypnnflilrgnhevisinrkygfkdevkrr....yslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsede

DLAQDLLWSDPMDVQTlasisdtpKYAKNiVRGLAHSFNDAAVRDVCRRLNLHLVVRAHQMIPEGFKFNSDRKLLTIFSAPRYMNESDNRGATLQVDVNG
 ||.||||.|| . .|         .|.|  || .. | .  |.|....|.. |..| ||.. .|..| .|.||.|.||||.|..| ||  | |.|| . 
clamdllwadpenkvt........gwaen.srgvsvifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderl

QLSISVMR
..|. |..
ivsfevlk
subfamily_PPP4C_pd Subfamily PPP4C 32-334 1.1e-54 178.6 In-house 17-281 (288) alignment 
Range on Protein: 32-334
Range on HMM: 17-281/288.0
EKSDLLLLIGQIMELFKMEKTLATISPPVTIVGDIHGQYPDLVRILnsriskeeakqKIVTSYSSNRFVFLGDYVDRGNHSIECICLVFALKVldlkfvs
.....  |  .. |..  |  . ..  |||. ||||||. ||....           |.  .  .....||||.|||| .|.|.. |. ||||       
keeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelf...........kvggdvpetnylflgdfvdrgfysvetfllllalkv.......

llvimfqiAYPTNFVLLRGNHETKAINFAYGFREELENRLGKKdgfEIWEKFNEVFSFMPLACLVGGRILCMHGGISEKLESLDSIDSIVRP--LPEVTD
         || . .|.|||||.. |  .||| .|  .. |.    ..|.   ||| ...||... |.|.|.|||.| ....|| | || |   .|.   
........rypdritlirgnhesrqitqvygfydeclrkygsa...nvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegp

LaQDLLWSDPMDVQTLAsISdtPkyaknivRGLAHSFNDAAVRDVCRRLNLHLVVRAHQMIPEGFKFNSDRKLLTIFSAPRYMNESDNRGATLQVDVNGQ
|  ||||||| |... | .|  |       ||  . | . .| . ... ...|..||||.. ||.|.  ..|.||..||| |     |  | |..| . .
l.cdllwsdpedaegwa.vs..p.......rgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeld

LSISV
   ..
kdfki
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 28-327 1.3e-53 175.2 In-house 17-281 (307) alignment 
Range on Protein: 28-327
Range on HMM: 17-281/307.0
QHVYEKSDLLLLIGQIMELFKMEKTLATISPPVTIVGDIHGQYPDLVRILnsrIskeeakqkIVTSYSSNRFVFLGDYVDRGNHSIECICLVFAlkvldl
.  | | ..  .| .   .|  ||.|  | ||. .|||.|||. ||. ..   |        ..       .|| |||||||  |.||| |.|.      
kiqytkeefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmf...i........llgrppetvyvftgdyvdrgllslecilllft......

kfvsllvimFQIAYPTNFVLLRGNHETKAINFAYGFREELENRLGKkDGFEIWEKFNEVFSFMPLACLVGGRILCMHGGISEKLESLDSIDSIVRPLPE-
         ..|.|| | ||||||||   .|  ||| ||    . |  | |||  |. .|  .|...|.  .|||||||.|  |  || .    .|. . 
.........ykicypenivllrgnheiarvnkkygfyeecvtsipk.cgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnp

VTDLAQDLLWSDPmDvqtlASISDtpkyAKNIVRGLAHSFNDAAVRDVCRRLNLHLVVRAHQMIPEGFKFNSDRKLLTIFSAPRYMNESDNRGATLQVDV
.  . .|.||.|| |     |. .     |   ||   .|    . |||.|| . |..|||||  .|.   | |||.|||||| | |   | |. |.|| 
frgivndmlwadp.d....psvfe....wkassrgsgftfgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvde

N
 
t
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 131-336 1.6e-53 175.0 In-house 120-313 (317) alignment 
Range on Protein: 131-336
Range on HMM: 120-313/317.0
SLLVIMFQIAYPTNFVLLRGNHETKAINFAYGFREELENRLGKKdgfeIWEKFNEVFSFMPLACLVGGRILCMHGGISEKLESLDSIDSIVRPLpEVTDL
 .|.. ....|| . .|||||||....|  ||| .| ..|  ..    ..| |. .|  .||. .|. .||||||||||.| .|. .| . ||| ...|.
villfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaa....lyeafqlafnvlplcavvnkkilcmhGGiseelldlkqldklkrpl.dipdv

--AQDLLWSDPMdvqtlasisDTPKYAKNIVRGLAHSFNDAAVRDVCRRLNLHLVVRAHQMIPEGFKFNSDRKLLTIFSAPRYMNESDNRGATLQVDVNG
    || |.||           . |. |.  || ...| ..||.. ...|.|.|||||||.. .|..| .||||.|||||| |  . || .| |.|| . 
Gvladltwadpd.........aevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavlsvdkkl

QLSISVMR
..||.|.|
kisinvlr
PPP_3 132-335 1.1e-52 171.7 In-house 77-269 (271) alignment 
Range on Protein: 132-335
Range on HMM: 77-269/271.0
LLVIMFQIAYPTNFVLLRGNHETKAINFAYGFREELEnrlGKKDGFEIWEKFNEVFSFMPLACLVGGRILCMHGGISEKLESLDSIDSIVRPLPEVTDL-
||.....| ||....|||||||.. ||  |||..|.     || | ....|..|||...||| |. ...|..|||.|....|||.| .. |.   ...  
llLlalkikypkevhLlRGnhEsrqinkvYgFkkevl...kkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegk

AQDLLWSDPMdvqtlasisDTPKYAKNIVRGLAHSFNDAAVRDVCRRLNLHLVVRAHQMIPEGFKFNSDRKLLTIFSAPRYMNESDNRGATLQVDVNGQL
  |||.|...         .. .  .| .||..  |   ........ .|.|..|||.. .||...  |.|..|.|||| |... .|.|| |... . . 
lldlllssdp.........ekeeglenskrGagllFgpdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealts

SISVM
.. ..
efkql
subfamily_PPP2C_pd Subfamily PPP2C 32-329 3e-52 170.6 In-house 18-277 (290) alignment 
Range on Protein: 32-329
Range on HMM: 18-277/290.0
EKSDLLLLIGQIMELFKMEKTLATISPPVTIVGDIHGQYPDLVRILnsriskeeakqKIVTSYSSNRFVFLGDYVDRGNHSIECICLVFALKVldlkfvs
|.|..  |. .. |... |. .  .. |||..||.|||. ||. ..           ||  .     ..||||||||| .|.|...|. ||||       
eesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelf...........kiggkspdtnylflgdyvdrgyysvetvtllvalkv.......

llvimfqiAYPTNFVLLRGNHETKAINFAYGFREELENRLGkkdGFEIWEKFNEVFSFMPLACLVGGRILCMHGGISEKLESLDSIDSIVRpLPEVTDL-
         |.   ..||||||.. |   ||| .|   . |     ..|. | ..| ..||..|| ..|.|.|||.| ....|| | .. | | || .  
........rykeritilrgnhesrqitqvygfydeclrkyg...nanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldr.lqevpheg

-AQDLLWSDPMDVQTLAsISDtpkyaknivRGLAHSFNDAAVRDVCRRLNLHLVVRAHQMIPEGFKFNSDRKLLTIFSAPRYMNESDNRGATLQVDVNGQ
   ||||||| | . .. ||.         ||  ..| .   ..  .. .|.|..||||.. ||...  ||.. |||||| | .   |..| |..| . .
plcdllwsdpddrggwg.isp.........rgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklk
PPP_5_Dcr2 60-289 9.9e-52 168.8 In-house 1-198 (199) alignment 
Range on Protein: 60-289
Range on HMM: 1-198/199.0
VTIVGDIHGQYPDLVRILNSRISKEEAkqkivtsysSNRFVFLGDYVDRGNHSIECICLVFALKvldlkfvsllvimfqIAYPTNFVLLRGNHETKAINF
||..||.|||. ||. ||  .. ...          ....||||||||||..|.|...|..|||               . || ...|||||||....| 
vtvcGDlHGqlddlllilfkeggdpse.........erlyvFlGDyVDrGkdslevlllLlalk...............lvypkevhllrGNHEdeqlne

AYGFREELENRLgkkDGFEIWEKFNEVFSFMPLACLVGGRILCMHGGISEKLESLDSIDSIVRP--LPEVTDLAQDL-LWSDPMdvqtlasiSDTPKYAK
 |||..|  ..    .| .|......||...||| |. ...|..|||.|....|..... | |.  .|| ..  .|| |||||.        ... ..  
iygftkevlsky...hgkkiykilsdvfdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdpr........daqegckl

NIVRGLAHSFNDAAVRDVCRRLNLHLVVRAHQM
| .||  . |.  ........ ||.|..|.|..
nseRGagllfgpdvtekfleknnlkliirshel
subfamily_PPP6C_pd Subfamily PPP6C 22-328 3.2e-51 167.2 In-house 4-274 (290) alignment 
Range on Protein: 22-328
Range on HMM: 4-274/290.0
NWINYRQH--VYEKSDLLLLIGQIMELFKMEKTLATISPPVTIVGDIHGQYPDLVRILNSriskeeAKQkivtsYSSNRFVFLGDYVDRGNHSIECICLV
.||.  ..     ..||  |  ....|.  | .. ..| |||..||||||. ||. ....      . |        ...|||||.|||| .|.| . ..
kwielakkckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrt......ggq.....vpdtsyvflgdfvdrgyysletftrl

FALKVldlkfvsllvimfqiAYPTNFVLLRGNHETKAINFAYGFREELENRLGKKDgfeIWEKFNEVFSFMPLACLVGGRILCMHGGISEKLESLDSIDS
..||.                || . .|||||||.. |  .||| .|  |. |. .    |  . .|| ....| .. ...||.|||.| ... ||.|  
ltlka...............kypdritllrgnhesrqitqvygfydeclnkygnan...awkyctkvfdlltiaaiideqvlcvhGglspdvktldqirv

IVRPL--PEVTDLaQDLLWSDPMDVQTLAsISDtpkyaknivRGLAHSFNDAAVRDVCRRLNLHLVVRAHQMIPEGFKFNSDRKLLTIFSAPRYMNESDN
| |    |.   .  ||.|||| ||.| | .|.         ||  . |    ... ..  ||.|..||||.. ||.|.  | || |..||| |     |
ieraqeiphkgaf.cdlvwsdpedvetwa.vsp.........rgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgn

RGATLQVDVNG
  . |... . 
vasilaledae
subfamily_PPP5C_pd Subfamily PPP5C 22-327 1.5e-48 158.4 In-house 26-297 (322) alignment 
Range on Protein: 22-327
Range on HMM: 26-297/322.0
NWINYRQHVYEKSDlLLLIGQIMELFKMEKTLATISP----PVTIVGDIHGQYPDLVRILNSRISkeeakqkivtSYSSNRFVFLGDYVDRGNHSIECIC
.... .... .|   | .. ...||.| . .|  |.      .|. ||||||. ||. |..   .          . ..| ..| ||.|||| .|.|.| 
elfkkqkklhkkya.lkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGl..........pseenpylfnGdfvdrGsfsvevil

LVFALKVLdlkfvsllvimfqiaYPTNFVLLRGNHETKAINFAYGFREELENRLGKKdgfeIWEKFNEVFSFMPLACLVGGRILCMHGGISE-KLESLDS
.....|.|               || .| | |||||.. .|  |||..| ...  .|    . . |.|||...||| ..  ..| .|||. . .  .|| 
tllgfkll...............yPnhfflsrGnhesdnmnklyGfegevkakytek....vadlftevfnwlPlahvinekvlvvhGGlfsedgvtldd

IDSIVRPL--PEVTdLAQDLLWSDPMDVQTLASiSDtpkyaknivRGLAHSFNDAAVRDVCRRLNLHLVVRAHQMIPEGFKFNSDRKLLTIFSAPRYMNE
.  | |    || . |  .|||||| . . ... |          ||... |     .  ..  ||.|..|.|..  ||.... | ||.|.|||| | ..
lrkidrnaqppeeg.llvellwsdpqeanGrsp.sk.........rGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdq

SDNRGATLQVDVN
..|.|| ...  .
mgnkgafitlrgd
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 36-335 4.3e-48 157.2 In-house 11-272 (280) alignment 
Range on Protein: 36-335
Range on HMM: 11-272/280.0
LLLLIGQIMELFKMEKTLATISPPVTIVGDIHGQYPDLVRILNsriskeeakqkIVTSYSSNRFVFLGDYVDRGNHSIECICLVFALKvldlkfvsllvi
.. .|  .  .|  |  |.    |. ..|||| || |. |...           ..     ....||||||||| . || . |.|.||            
iiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfd...........ligrvpeeklmflgdyvdrgpqgievlillfclk............

mfqIAYPTNFVLLRGNHETKAINFAYGFREELENrlgkKDGFEIWEKFNEVFSFMPLACLVGGRILCMHGGISEKLESLDSIDSIVRPL-PEVTDLAQDL
   | |     |||||||| ..|  |||  | .     | |  .|  |. .|  ||.. |.  |.||||||.| .|  ||.|  | ||  |    |  ||
...iryrdriyllrgnhetpsvnkiygfyvecqy....kygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidl

LWSDPMDVQTlasisdtpKYAkNIVRGLAHSFNDAAVRDVCRRLNLHLVVRAHQMIPEGFKFNSDRKLLTIFSAPRYMNESDNRGATLQVDVNGQLSISV
||||| .            .    .||... |  . | . |. |.. |..||||.. .|... . |.|.|.|| | |  .  |  | . .. | |.|.  
lwsdptnkge........gwf.hsirgisymfgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqq

M
.
l
subfamily_PPPLV_pd Subfamily PPPLV 39-325 6.6e-48 156.5 In-house 5-276 (290) alignment 
Range on Protein: 39-325
Range on HMM: 5-276/290.0
LIGQIMELFKMEKTLATISPPVTIVGDIHGQYPDLVrILNSRISKEEakqkivTSYSSNRFVFLGDYVDRGNHSIECICLVFALKVLdlkfvsllvimfq
|  . .. .  |. |  .  |. ..||.||.| ||. .... . .        .  .   ..|||||||||..|.| |. ..|||||             
lcdvavdilaaeerllelksptyvlgdlhgnyrdli.yfekvlwrtg......vdltpasllflgdyvdrgdfsveliayllalkvl.............

iaYPTNFVLLRGNHETKAINFAYGFREELENRLGKKDgFEIWEKFNEVFSFMPLACLVGGRILCMHGGISEKLES---LDSIDSIVRPLPEVTD---LAQ
  ||. ..||||||| ...  .. .. |   . |..   |.|| ||.|| ..|||  .  ...|.|.|| .   .   . .|. |.  |..  |   || 
..ypskvlllrgnhelesvqesieykgegsfkfgdsl.eevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplal

DLLWSDPMDVQT---LASISDTPKYAKNIVRGLAHSFNDAAVRDVCRRLNLHLVVRAHQMIPEGFKFNSDRKLLTIFSAPRYMNESdNRGATLQVD
|.||||| . .     .  .    ...|  || .| |  .|.    .| ||  |.|||..  .|...  . .|||.||. ||   | |  | . ||
dilwsdpaedrdlslrgelvlneGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGss.neaalilvd
subfamily_PPG1_pd Subfamily PPG1 38-329 1.3e-47 155.6 In-house 21-287 (300) alignment 
Range on Protein: 38-329
Range on HMM: 21-287/300.0
LLIGQIMELFKMEKTLATISPPVTIVGDIHGQYPDLVRILnsriskeeakqKIVTSYSSNRFVFLGDYVDRGNHSIECICLVFALKvldlkfvsllvimf
 |. .. ||.  |  .  |  |||.|||.|||. |.. |.           ||        ..||||||||| .|.| | |. .||              
eltdklkellvkesnvieirspvtvvgdvhgqfydvleif...........kiggqvpdtnylflgdyvdrglysvetisllivlk..............

qIAYPTNFVLLRGNHETKAINFAYGFREELENRLGKKDgfEIWEKFNEVFSFMPLACLVGGRILCMHGGISEKLESLDSIDSIVR--PLPEVTDLAqDLL
 . ||.   |||||||.. |  .|||  |  .. | .    .|. . |.| .. ||...   | |.|||.| .  |.| |  . |   .|.   || |||
.lrypsritllrgnhesrqitqvygfyteclrkyggns..rvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegala.dll

WSDPM--DVQTLASISDTPKYAKNIVRGLAHSFNDAAVRDVCRRLNLHLVVRAHQMIPEGFKFNSDRKLLTIFSAPRYMNESDNRGATLQVDVNGQ
||||   .  ||    .  .. ..  ||  .|.    |    |  ... ..||||.  ||..   | || |..||| | .   |. . |..  . .
wsdpeennnptldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekde
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 88-337 1e-46 152.6 In-house 113-333 (339) alignment 
Range on Protein: 88-337
Range on HMM: 113-333/339.0
QKIVTSYssNRFVFLGDYVDRGNHSIECICLVFALKvldlkfvsllvimfqIAYPTNFVLLRGNHETKAINFAYGFREELENRLGKkdgfEIWEKFNEVF
... | |  .|..|||||||||  |.| . |. |||               .|||    |||||||....| .|||  |.. |       ...| |...|
kevttgy..krylflgdyvdrgpfsmevvilltalk...............laypdriyllrgnhesrsvntsygfyrevnyryda....qlyecfqnmf

SFMPLACLVGGRILCMHGGISEKLESLDSIDSIVRPL--PEVTDLaQDLLWSDPmdvqtlasiSDTPKYAKNIVRGLAHSFNDAAVRDVCRRLNLHLVVR
  .|.....   |.||||||||.| |.. .  . |||  |.|  |  || |.||           | |  |   || .  |   |.| . ..|.|..|.|
nvfpfcavinntimcmhggisehltsfnqfsvfkrpleipdvgvl.tdltwadp.........dptekgykpsargasfvfgppalraflkkldlqmvir

AHQMIPEGFKFNSDRKLLTIFSAPRYMNESDNRGATLQVDVNGQLSISVMRY
 ||.. .|..|   |.|.|||||| |  . ||  | . .| . ..|| |.| 
ghqvvedgyeffdgrrlvtifsapnycgqndntaavfsidkklkisinvfrp
Metallophos Calcineurin-like phosphoesterase 59-290 2.3e-38 125.5 Pfam-A 2-199 (200) alignment 
Range on Protein: 59-290
Range on HMM: 2-199/200.0
PVTIVGDIHGQYPDLVrilnsrIsKEEAKQKIVTSYSSNRFVFLGDYVDRGNHSIECICLVFalkvldlkfvsllVIMFQIAYPTNFVLLRGNHETKAIN
.....||.||.. ||       .  ... .||  .   . ..||||.||||..|.|...|.                . ....|....||||||| . .|
rilvigDlHgglddle......d.lllillkiaaeekpdlvlflGDlvdrgdwssetlalld.............ylvlklllpipvfllrGNHesdpgn

FAYGFREELENR------------------------------LGKKDGFEIWEKFNEVFSFMPLACLVGGRILCMHGGISEKLESLDSIdsivrplpevt
.||||..|  ..                              |....|....|...|.| ..||. ||.|.||..||..|. ..| | |           
saygflleqlkdlrglangeeeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...........

dlaqdllwsdpmdvqtlasisdtpkyaknivrgLAHSFNDAAVRDVCRRLNLHLVVRAHQMI
                                  .  |.  |... ... .. ||.|.|.  
.................................gselfgpdalekllekygvdlvlrGHtHk
PPP_4 132-289 4e-37 121.2 In-house 49-196 (197) alignment 
Range on Protein: 132-289
Range on HMM: 49-196/197.0
LLVIMFQIAYPTNFVLLRGNHETKAINFAYGFREELENRlgkkDGFEIWEKFNEVFSFMPLACLVGGRILCMHGGISEKLESLDSIDSIVRPL--PEVTD
||.. ... ||...||||||||.|..|  |||..|. ..    .| ||..|...||...||| |. ...|..|||.|..|||||.|. | |.   |    
llLlalklvypkevvllRGNHEskslnllygfkkevlek....hgkeilkklqdvfdllplaalidekvlvvhgglsdelesldkierierkiespleee

LAQDL-LWSDPMdvqtlasiSDTPKYAKNiVRGLAHSFNDAAVRDVCRRLNLHLVVRAHQM
...|| |||||.        ... ..|.. |||  . | . ........ ||.|..|.|..
krkdlllwsdpr........eaqeglans.vrGagllFgpdvtekfleknnlkliirshel
PPP_2 132-289 1.8e-36 118.7 In-house 47-197 (198) alignment 
Range on Protein: 132-289
Range on HMM: 47-197/198.0
LLVIMFQIAYPTNFVLLRGNHETKAINFAYGFREELEnrlGKKDGFEIWEKFNEVFSFMPLACLVGGRILCMHGGISEKLESLDSIDSIVRPLPEVTDLA
||...... ||....|||||||.| .|  |||..|.     || | ....|..|||...||| |. ...|..|||.||....||.| .. |.   ... .
llllalklvypkevhLlRGnhEskkvnkvygFkkevl...kkkggkkvykklqevfelLplaalidekvlvvHGGlseeiklldqikkeerkiespeegk

QDLLWsdpmDVQTLASISDTPKYAKNIVRGLAHSFNDAAVRDVCRRLNLHLVVRAHQM
   |       . | . ... .  .| .|| .  |.  ........ .|.|..|||..
lldll....eeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
subfamily_PPP7C_pd Subfamily PPP7C 46-222 4.7e-31 100.9 In-house 52-201 (383) alignment 
Range on Protein: 46-222
Range on HMM: 52-201/383.0
LFKMEKTLATISPPVTIVGDIHGQYPDLVRILNsriskeeakqKIVTSYSSNRFVFLGDYVDRGNHSIECICLVFAlkvldlkfvsllvimFQIAYPTNF
| ....  ..||  ||. ||.||.  ||. ||           |     ..| .|| ||.||||..|.| .....|               . ..||...
lpnisrvstaiskevtvcGdlhGklddlllily..........knGlpseenpyvfnGdfvdrGkesveillilla...............lllvypkev

VLLRGNHETKAINFAYGFREELENRLgKKDGFEIWEKFNEVFSFMPLACLVGGRILCMHGGISEKLeSLDSIDSIVR
 | ||||| . .|  |||  |.|..  |. | .| . ...||...|||.|.  .|| .|||||.|  .|. .|.| |
ylnrGnhedhilnlryGfikevesky.kvhgkkilrlledvfawlplatlidekilivhGGisdkt.dlelldkier
PPP_3 32-129 2e-23 75.8 In-house 3-89 (271) alignment 
Range on Protein: 32-129
Range on HMM: 3-89/271.0
EKSDLLLLIGQIMELFKMEKTLATISPPVTIVGDIHGQYPDLVRILNSRISKEEakqkivtsyssNRFVFLGDYVDRGNHSIECICLVFALKVLDLKF
....|  |. .. |... |..| .|| |||..||||||. ||... ..  . .|           ....|||||||||..|.|...|..|||..  | 
senelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspe...........tkYlFlGdyVDrGkkslEvlllLlalkikypke
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 10-124 6.3e-22 71.0 In-house 3-106 (298) alignment 
Range on Protein: 10-124
Range on HMM: 3-106/298.0
IHQFIKSHLFVKNWINYRQHVYEKSDLLLLIGQIMELFKMEKTLATISPPVTIVGDIHGQYPDLVRILNSriskeeakqkiVTSYSSNRFVFLGDYVDRG
..... ..| |    .   .| ...|.  || . ...||  |.|  . .|... |||||||.||.|...             .   .. ..|||||||||
vdellievlsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdk...........agfppdanylflGdyvdrG

NHSIECICLVFALKV
....| |.|..| ||
rqnlevivlllaykv
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 31-133 5e-19 61.3 In-house 10-101 (287) alignment 
Range on Protein: 31-133
Range on HMM: 10-101/287.0
YEKSDLLLLIGQIMELFKMEKTLATISPPVTIVGDIHGQYPDLVRILNSriskeeakqkiVTSYSSNRFVFLGDYVDRGNHSIECICLVFALKVLDLKFV
.. .|.| .. .| |...  ..|  .  |.|||||||||. ||.||.|.           |   .  ...|||||||||..|.| . |.|.||..  | |
fsdkdilevlekieeileplpalleveapitivGdihGqlddllrifna...........vGaapkvqylflGdyvdrGakslevslllfslkiaypkkv

SLL
 ||
hll
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 32-124 5.9e-19 61.3 In-house 7-88 (280) alignment 
Range on Protein: 32-124
Range on HMM: 7-88/280.0
EKSDLLLLIGQIMELFKMEKTLATISPPVTIVGDIHGQYPDLVRILNSRiskeeakqkivTSYSSNRFVFLGDYVDRGNHSIECICLVFALKV
.. |.  .| .  .......|.  .  ||...||.||||.||.|...             .    . ..|||||||||.. .| |.|..| ||
keadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarv...........sfppdqnylflgdyvdrgrqqlevillllaykv
PPP_2 60-130 2e-18 59.8 In-house 1-60 (198) alignment 
Range on Protein: 60-130
Range on HMM: 1-60/198.0
VTIVGDIHGQYPDLVRILNSRISKEEakqkivtsyssNRFVFLGDYVDRGNHSIECICLVFALKVLDLKFV
||..||.|||. ||... ..  ...|           ....|||||||||..|.|...|..|||.   | |
vtvcGDlHGqldDLlilfknglpspe...........rkylFlGdyvDrGkkslEvlllllalklvypkev
PPP_4 60-126 5.2e-18 58.8 In-house 1-58 (197) alignment 
Range on Protein: 60-126
Range on HMM: 1-58/197.0
VTIVGDIHGQYPDLVRILNSrISKEEAKQkivtsyssNRFVFLGDYVDRGNHSIECICLVFALKVLD
||.|||||||. ||. .|   .. .....        ...||||||||||..|.|...|..|||.  
vtvvGDiHGqlddlllkllk.ngglpsee........rsyvflGDyVDRGkdslevlllLlalklvy
subfamily_PPP7C_pd Subfamily PPP7C 233-340 7.2e-16 50.9 In-house 239-335 (383) alignment 
Range on Protein: 233-340
Range on HMM: 239-335/383.0
DLLWSDPMDVQTLasisdtpkyAKNIVRGLAHSFNDAAVRDVCRRLNLHLVVRAHQMIPEGFKFNSDRKLLTIFSAPRYMNESDNRGATLQVdvNGQLSI
|.|||||.  .             |..||    |     ... .. ||.|..|.|.  |||..|  |.|.||||||  | .|  |||| ...  . .|  
dilwsdpkakeGc.........kpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvkl..gkdltp

SVMRYTKP
 ...|   
rivqyqas
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 94-127 1.3e-09 30.7 In-house 98-131 (317) alignment 
Range on Protein: 94-127
Range on HMM: 98-131/317.0
YSSNRFVFLGDYVDRGNHSIECICLVFALKVLDL
 . ....||||||||| .||| . |.||||.|  
kgykkylflGdyvdrGpfsievvillfalkllyp
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 28-78 4e-08 25.8 In-house 6-56 (317) alignment 
Range on Protein: 28-78
Range on HMM: 6-56/317.0
QHVYEKSDLLLLIGQIMELFKMEKTLATISPPVTIVGDIHGQYPDLVRILN
|.......|. |  .  |||  |.    .  |||||||||||. ||. .|.
qdlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalld