Synonym: CELE_F33G12.6, F33G12.6
Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
| Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
|---|---|---|---|---|---|---|---|---|---|
| subfamily_CG9081_pd | Subfamily CG9081 | 205-390 | 1.8e-73 | 236.9 | In-house | 1-192 (195) | alignment | ||
Range on Protein: 205-390
Range on HMM: 1-192/195.0
AGEPIADVWGVVGRNNNGVMALADGVNWGEGARLAARCAIRGAIDHLNTRVIK-DSLADTTEVFHEMLAAFHSAHSLILQEGGMLTTLCVALVAPVRR--
||||.|||..|| |.|| .||||||||||. ||||||.|..||...|| .. | .. ... ..|. .| ... |.. ||...| ||||..|.|. ..
agePvadvfavvarennaimaladGvnWGkkarlaarsavagavaylndklfklsakpnsrdlfklllesleeaqksilensgtlttlsiavvcelkank
--GNGWALCVCNVGDSLCFVYNRHYG-VREVTLGSHDIDQMRDMRDAGGALGPVDGRNPQLHNLTCSMTFVEEGDVVFITSDGVSDNFDPVV
. |.|.| .||||..|||..... |||||..||. | .||.|..||||||..| .| |.||..|.. |.|||.||.|||||||||||||
kissqWglfvvsvGdspvfvyspdnksvrevtvashskdgirdvrlsGGalGpaiGtdpdlenlslsylpvaeGdivfltsdGvsdnfdPvv
|
|||||||||
| subfamily_CG9801_pd | Subfamily CG9801 | 205-402 | 2.9e-71 | 229.8 | In-house | 2-228 (252) | alignment | ||
Range on Protein: 205-402
Range on HMM: 2-228/252.0
AGEPIADVWGVVGRNNNGVMALADGVNWGEGARLAARCAIRGAIDHLNTRVIKDSlADTTEVFHEMLAAFHSAHSLILQEGGML-----TTLCVALVAPV
.|.||||...|| |.|. ..|||||.||||....|||.|....||.|.....|.. ....||....|||...||. |......| |||........
eGdPiaDkftvvvrknrlilalaDGcnWGerpaeaarsasaafidylskalskei.ttvqevgksllaaleeahksivegkselweaGtttLlggvllel
RR------------------------GNGWALCVCNVGDSLCFVYN-RHYGVREVTLGSHdiDQMRDMRDAGGALGP-VDGRNPQLHNLTCSMTFVEEGD
.. .. |......|||...|.|. ....|...| |.. ....|.|||||.||| |....|.|.||....|.|||.|
ekeaekpesssqlgksevglsasnassskwgfvcasvGDckaflysakkkevtditkgnr..snlsDarDagGrLGPyveqgkPdLrnLklfftlveeeD
VVFITSDGVSDNFDPVVGKFCVIKKS-EHE
.....||||.||.||.. .... ... . |
iillvsDGvhDnlDPqtlgktprdlnlnae
|
|||||||||
| subfamily_Sponge-PPM-1_pd | Subfamily Sponge-PPM-1 | 206-390 | 9.8e-64 | 204.6 | In-house | 2-193 (199) | alignment | ||
Range on Protein: 206-390
Range on HMM: 2-193/199.0
GEPIADVWGVVGRNNNGVMALADGVNWGEGARLAARCAIRGAIDHLNTRVIKDSLAD--TTEVFHEMLAAFHSAHSLILQEGGMLTTLCVALVAPV----
|||.|||..|| |.|| .||.|||||||. .|||||||..||| ... .. | | . .... .| ... || ||...| |||| .|.| .
GepvadvfavvarennaimaiadGvnwGkkprlaarcavqgaiayisdnlfklsakptnsrtltklllesldeahksileheGtlttlsiavvcelkpns
RRGNGWALCVCNVGDSLCFVYNRHY-GVREVTLGSHDIDQMRDMRDAGGALGPVDGRNPQLHNLTCSMTFVEEGDVVFITSDGVSDNFDPVV
| . |.|.| |||| .|||. .. |.|.| || | .|..|..|||||| | .| |.||..|. |.|||.|..|.||.||||.|||
rsssrwglfvasvGdspvfvyspdtksvheatvachdkdGirtarlsGGalGpaiGtdpdlenlslsylpvaeGdivllttdGisdnfapvv
|
|||||||||
| 0049733 | PP2C-like | 211-388 | 9.4e-18 | 57.6 | In-house | 20-194 (235) | alignment | ||
Range on Protein: 211-388
Range on HMM: 20-194/235.0
DVWGVvgrnNNGVMALADGVNWGEGARLAARCAIRGAIDHLNTRVIKDSLADTTEVFHEMLAAFHSAHSLILQEGGMLTTLCVALVApvrrgnGWALCVC
| . | . ...|.|||.. ......|...... ...| . . | .. ...|... .|... . || ||..|||. | |.|.
Davlv....glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallelalaspelagmgtTavvalld......ggklyva
NVGDSLCFVYNrHYGVREVTLGSHDIDQMRDM--RDAGGALgpvdgRNPQLHN-----------LTCSMTFVEEGDVVFITSDGVSDNFDP
||||| ..... . .. .| . ... .. ..||||. | |. . ... .|.||.....|||..|....
nvGDsrayllr.dgklvqltedhspvnelerqriitaggav.....rvpgrlaltralGdlllkpdvtvlelepgdflllasDGlwdvlsd
|
|||||||||
| subfamily_tipA_pd | Subfamily tipA | 304-392 | 1.2e-15 | 47.1 | In-house | 152-241 (296) | alignment | ||
Range on Protein: 304-392
Range on HMM: 152-241/296.0
GWALCVCNVGDSLCFVYNRH-YGVREVTLGSHdiDQMRDMRDAGGALGP-VDGRNPQLHNLTCSMTFVEEGDVVFITSDGVSDNFDPVV-GK
| . ||| | . .. | ..| | . | .|.|| ||| |. .| | ||. ....|| |.... |||| ||.|| ||
kWgfvcasvGdckafllskkskevtditkgnr..snvddakdpGGrlGPyveqGkPdlrnlklffllceeediillvsdGvhdnldPktlgk
|
|||||||||
| PP2C_2 | Protein phosphatase 2C | 205-387 | 1.4e-13 | 43.7 | Pfam-A | 8-182 (212) | alignment | ||
Range on Protein: 205-387
Range on HMM: 8-182/212.0
AGEPIADVWGVVGRNNNGVMALADGVNWGEGARLAARCAIRGAIDHLNTRVIKDSLADTTEVFHEMLAAFH-------SAHSLILQEGGMLTTLCVALVA
.|.| | ... .. ..| |||. .... .||.| . |...| . . ..|........ ..... . .|.. . . |||..|...
kgkpcqDalaireasdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavit
PvrrgNGwaLCVCNVGDSLCFVYNRHYGVREVTLgshdidqmRDMRDAGGALGPVDGRNPQLHNLTCSMTfVEEGDVVFITSDGVSDNFD
| .. ......||. ..|..| |. .. .| ... . . .. .... . . ... .|.|| .....|||||..
p....ge..ivffqiGDgaivvrdrdgevqllge........pdsgeyanettfltsedaeeelrirrlk.lepgdalllmTDGvsdslr
|
|||||||||
| PP2C_2 | Protein phosphatase 2C | 205-387 | 1.4e-13 | 43.7 | In-house | 8-182 (212) | alignment | ||
Range on Protein: 205-387
Range on HMM: 8-182/212.0
AGEPIADVWGVVGRNNNGVMALADGVNWGEGARLAARCAIRGAIDHLNTRVIKDSLADTTEVFHEMLAAFH-------SAHSLILQEGGMLTTLCVALVA
.|.| | ... .. ..| |||. .... .||.| . |...| . . ..|........ ..... . .|.. . . |||..|...
kgkpcqDalaireasdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavit
PvrrgNGwaLCVCNVGDSLCFVYNRHYGVREVTLgshdidqmRDMRDAGGALGPVDGRNPQLHNLTCSMTfVEEGDVVFITSDGVSDNFD
| .. ......||. ..|..| |. .. .| ... . . .. .... . . ... .|.|| .....|||||..
p....ge..ivffqiGDgaivvrdrdgevqllge........pdsgeyanettfltsedaeeelrirrlk.lepgdalllmTDGvsdslr
|
|||||||||
| subfamily_tipA_pd | Subfamily tipA | 205-283 | 1.5e-13 | 40.2 | In-house | 6-82 (296) | alignment | ||
Range on Protein: 205-283
Range on HMM: 6-82/296.0
AGEPIADVWGVVGRNNNGVMALADGVNWGEGARLAARCAIRGAIDHLNTRviKDSLADTTEVFHEMLAAFHSAHSLILQ
.|.|||| . |. ..| ..||||| |||. . ||. |. . .|.|. . .. . .. . .|.||. || |..
egdpiadrftvqvyknrlivaladGcnWGkrPaeaatnasaafvdflsek..sseintvkdaGkfllsafeaahkkive
|
|||||||||
| PP2C_SIG_SM00331 | 212-386 | 5.8e-13 | 41.9 | In-house | 20-164 (217) | alignment | |||
Range on Protein: 212-386
Range on HMM: 20-164/217.0
VWGVVGRNN-NGVMALADGVNWGEGARLAARCAiRGAIDHLNTRVikdslADTTEVFHEMLAAFHSAhsliLQEGGMLTTLCVALVaPVRRGNgwaLCVC
. .|| |. ....|||. | | .|.. . |.|...| .. ......... |... .|.|| .||..||. . ..|. | ..
yydvvklnegrlllvvaDgmGkGlaAaaassql.rtalrellseg.....eelsqalkrlnraiyee....keekgmfaTlllaly.dfssgk...lsya
NVGDSLCFVYNrHYGVREVTLGshdidqmrdmrDAGGALGPVDGRNpqlhnLTCSMTFVEEGDVVFITSDGVSDNF
|.||| ..... . | . .| .|| . .. .. ... .|.||.... .||. ..
naGdsrpyllr.dgklveilkd...........vegaplGlepevs.....vdirelelekgdllllytDGltear
|
|||||||||
| 0034914 | PP2C-like | 208-387 | 3.5e-12 | 39.0 | In-house | 34-245 (295) | alignment | ||
Range on Protein: 208-387
Range on HMM: 34-245/295.0
PIADVWGVVG-----RNNNGVMALADGVNWGEGARLAARCAIRGAIDHLNTRvIKDSLADTTEVFHEMLAAFHSAHSLILQE-------GGMLTTLCVAL
. | . || .. ......||.. . |..|.. ... ...|. . . ... . . . ||..|. .|.. |. ||..|||
sneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekl.lllltlsledieealrkaflaadeellelallrpelagsGtTavval
VapvrrgNGWALCVCNVGDSLCFVYnRHYGVREVTLGSHDID--QMRDMRDAGGAL---------------GPVDGR--------------NPQLHNLTC
. | | |.||||| .... |. .. .| . . .. ...|||| | .| |... |..
i......rgnklyvanvGDSravll.rngelvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdfdlklllslllleplvsaePdvtvlel
SmtfVEEGDVVFITSDGVSDNFD
. .|..|.. . |||..|...
t...ledddfllLasDGlwdvls
|
|||||||||
| PP2Cc_SM00332 | 205-322 | 2.5e-08 | 26.7 | In-house | 20-139 (274) | alignment | |||
Range on Protein: 205-322
Range on HMM: 20-139/274.0
AGEPIADVWGVVGR----NNNGVMALADGvnwgEGARLAARCAIRGAIDHLNTRVIKDSLADTTEVFHEMLAAFHSAHSLILQEG--------GMLTTLC
. ... |.. || . .. ......|| .| .|... . ..|. . |.. . .| . || |... ||.| .. .|..
wrksmeDahvvvvdlveeedwlffgvfDG....hgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskelenalsGstav
VALVAPVRrgngwaLCVCNVGDSLCFVYNR
|||.. . | |.||||| .....
vallkked......lyvanvGDSravlcrn
|
|||||||||
| SpoIIE | Stage II sporulation protein E (SpoIIE) | 257-391 | 5.1e-06 | 18.4 | Pfam-A | 39-143 (193) | alignment | ||
Range on Protein: 257-391
Range on HMM: 39-143/193.0
KdsladttevFHEMLAAFHSAHSLILQEGGMLTTLCVALVAPVRRgngwALCVCNVGDSLCFVYNRHYgvrevtlgshdiDQMRDMRDAGGALGPVDGrn
. ..|.|.. ..| . |.|. . .|...| . | .. | ..|.|.. ....... .. . | .|| ...
e.........paevlerlnealarnleeeerfatavlaeydpstg....kleyanaGhpppllvrpdg............gtkfllvstglplGilpe..
pqlHNLTCSMTFVEEGDVVFITSDGVSDNFDPVVG
.. .. .|.||.... .||| .. || .
...adyeeaelqlepgdllllyTDGvtEardpdge
|
|||||||||
| SpoIIE | Stage II sporulation protein E (SpoIIE) | 257-391 | 5.1e-06 | 18.4 | In-house | 39-143 (193) | alignment | ||
Range on Protein: 257-391
Range on HMM: 39-143/193.0
KdsladttevFHEMLAAFHSAHSLILQEGGMLTTLCVALVAPVRRgngwALCVCNVGDSLCFVYNRHYgvrevtlgshdiDQMRDMRDAGGALGPVDGrn
. ..|.|.. ..| . |.|. . .|...| . | .. | ..|.|.. ....... .. . | .|| ...
e.........paevlerlnealarnleeeerfatavlaeydpstg....kleyanaGhpppllvrpdg............gtkfllvstglplGilpe..
pqlHNLTCSMTFVEEGDVVFITSDGVSDNFDPVVG
.. .. .|.||.... .||| .. || .
...adyeeaelqlepgdllllyTDGvtEardpdge
|
|||||||||
| PPM_PTC7_SpoIIE | 253-386 | 5.4e-06 | 19.4 | In-house | 60-170 (230) | alignment | |||
Range on Protein: 253-386
Range on HMM: 60-170/230.0
TRViKDSLADTTEVFHEMLAAFHSAH--SlilqEGGMLTTLCVALVAPVRrgngWALCVCNVGDSLCFVYNRHYGvrevtlgshdidqmrD---MRDAGG
.. . .| . |.... .|.. .. . .. . .|..|||. | . . | |.|.||| ..... . | |
ela.faglekpeeilrrlnlalaadlede....psssgaTavvalidpst....gklyvanaGdsppllvrddgg...............ererivaggl
A-LGPVDGRNPQLHNLTcsmtfVEEGDVVFITSDGVSDNF
. || .|| . .... ..||. . .||| ..
pslGilpgrvfgvlavs.....lapGdllllytDGvveae
|
|||||||||