Gene F42G9.1 in Caenorhabditis elegans

Synonym: CELE_F42G9.1, F42G9.1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1G
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP084_AA protein Get Run
CeleP084_AA_2-487 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1G_pd Subfamily PPM1G 4-488 8.2e-203 667.6 In-house 1-472 (473) alignment 
Range on Protein: 4-488
Range on HMM: 1-472/473.0
YLNKPIIEKEKEEGSGNGLSYACTTMQGWRVNQEDAHNCVVDLHTDWHMFGVYDGHGGTEVSKFTSAKLPDFLKERKFWEADDVAECLQKAFVDFDDFIR
||.||..|||.|..| ..|||....||||||.|||||||..||..|...|.|||||||.||.|....||||.||..|.....||...|..||...|....
ylskpkvekesedesneelsygasamqGwrvsqEDahncitdldedtslfavyDGHGGkevakyvakklpdllkaqkgykegdvekaleeaflalDeklk

AEESMKELKDIGD--EGKPKKaggEADSEDEADRIDTI-EEASVPLAELLKRYGGAGVGKSLLSAFLAKGDVSDDSEDEDEDEEEAEEQDDTEEKKENED
||||.||||.|..  |.....   |.|.|...|.|... |||..||.|||||. |.|..|. ||..|..|..|.|.|||||||||.||..||||....|.
aeeslkelkeiaeaeededee...eeddeededeiellteeaeipldellkrldgdgsekeelsqallegaasedeedededeeeeeeekdteeeskeee

ASAEVVIENAEDKEEEEGSPKKKGQKRCQkspiqSEAKKSKSETDAETAPssssgvdgvateEEDEDDSDKEFVADEEEDDEDAEDEQSDEEMVDGSLAP
..|....|....|.||. |.|.. .....     .|....|.||..|...            .|||.....|. |.|||..||.|||...||...|..| 
kkakaakegkqekkeedesekeeeeeeke.....eeeedekgeteeeeee............dedeeeeedeeeaeeeeeeedeedeeeeeedgegeeak

LLL-GSGGAEVPGEDSGTTACVCLVGKDKVIVANAGDSRAVLCRNGKAVDLSVDHKPEDEVETNRIHAAGGQIE-DGRVNGGLNLSRAFGDHAYKKNQEL
  | ||...|.|||||||||.|.|. ..|.|||||||||.||.|||||.|||.|||||||||..||..|||... |||||||||||||.||||||||.||
eeldgseekeepGedsGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeL

GLKEQMITALPDVKIEALTPEDEFIVVACDGIWNSMESQQVVDFVRDLLAKGS--SCAEVCDALCDACLADSTDGDGTGCDNMTVICTTFDR
.||||||.||||.|...||.||||.|.|||||||.||||.||||||. |.||.  ...|....|.|||||..|.||||||||||||......
plkeqmisAlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtviivllkk
PP2Cc_SM00332 13-484 1.4e-112 368.6 In-house 1-274 (274) alignment 
Range on Protein: 13-484
Range on HMM: 1-274/274.0
EKEEGSGNGLSYACTTMQGWRVNQEDAHNCVVDL--HTDWHMFGVYDGHGGTEVSKFTSAKLPDFLKERKFWEAD----DVAECLQKAFVDFDDFIRAEE
|.|.||..||||....|||||...||||..||||  ..||..|||.|||||.||.||.|.|||..|||......|    ||.|.|.|||...|..|..||
esesgsnlglsygkssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileee

SMKELKDigdegkpkkaggeadsedeadridtieeasvplaellkryggagvgksllsaflakgdvsddsedededeeeaeeqddteekkenedasaevv
..|||..                                                                                             
qskelen.............................................................................................

ienaedkeeeegspkkkgqkrcqkspiqseakksksetdaetapssssgvdgvateeededdsdkefvadeeeddedaedeqsdeemvdgslaplllgsg
                                                                                                    
....................................................................................................

gaevpgEDSGTTACVCLVGKDKVIVANAGDSRAVLCRNGKAVDLSVDHKPEDEVETNRIHAAGGQIEDGRVNGGLNLSRAFGDHAYKKNQelGLKEQMIT
      ..||.||.|.|. |....|||.||||||||||||||.||||||||||.|..||..|||..|.|||||||..|||||||..|||.  .|||..||
......alsGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdhflkknk..klkepyit

ALPDVKIEALTPEDEFIVVACDGIWNSMESQQVVDFVRDLLAKGS-SCAEVCDALCDACLADStdgdGTGCDNMTVICT
|.||||...||.||||...|.||.|.....|.|||.||.|||||.   .. ...|.|......    |...||.||...
aepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairr....ggseDniTvvvv
0034914 PP2C-like 3-487 4.4e-79 258.2 In-house 2-291 (295) alignment 
Range on Protein: 3-487
Range on HMM: 2-291/295.0
AYLNKPIIEKEKEEGSGNGLSYACTTMQGWRVNQEDAHNCVVDL---HTDWHMFGVYDGHGGTEVSKFTSAKLPDFLKE-------RKFWEADDVAECLQ
..|..|..|. .   . . |.... ..||.| ..|||. .|..|   ..|...|||.||||| ..... |  |...|.|          .. .|..|.|.
lllslpllellllsslllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealr

KAFVDFDDFIRAEESMKelkdigdegkpkkaggeadsedeadridtieeasvplaellkryggagvgksllsaflakgdvsddsedededeeeaeeqddt
|||.  |  ....  ..                                                                                   
kaflaadeellelallr...................................................................................

eekkenedasaevvienaedkeeeegspkkkgqkrcqkspiqseakksksetdaetapssssgvdgvateeededdsdkefvadeeeddedaedeqsdee
                                                                                                    
....................................................................................................

mvdgslaplllgsggaeVPGEDSGTTACVCLVGKDKVIVANAGDSRAVLCRNGKAVDLSVDHKPEDEVETNRIHAAGGQIEDGRVNGGLNLSRAFGDHAY
                      |||||.|.|. ..|..|||.|||||||.|||..| |.||||| .| |  || .||| . .|||||.|...||.||. .
.................pelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdfdl

KKNQELGLKEQMITALPDVKIEALT-PEDEFIVVACDGIWNSMESQQVVDFVRDLLAKGSSCAEVCDALCDACLAdstdgdGTGCDNMTVICTTFD
|..  | |.|....| |||..  || ..|.|...|.||.|. ......||.||.||||| .. |....|.|..||      . ..||.||..  ..
klllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAla......rgsrDNiTvvvvrln
subfamily_PPM1G2_pd Subfamily PPM1G2 311-486 2.8e-65 213.1 In-house 111-286 (287) alignment 
Range on Protein: 311-486
Range on HMM: 111-286/287.0
PGEDSGTTACVCLVGKDKVIVANAGDSRAVLCRNGKAVDLSVDHKPEDEVETNRIHAAGGQIEDGRVNGGLNLSRAFGDHAYKKNQELGLKEQMITALPD
  |..|.|| | |. ..|..|||||||||||. .|..  ||.||||..| |..|| |||| .| .|||| | ||||.||...|||.... .||..||.||
kdesaGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfvelnrvngnLalsralgDfefkknvkkkpeeqivtavPD

VKIEALTPEDEFIVVACDGIWNSMESQQVVDFVRDLLAKGSSCAEVCDALCDACLADSTDGDGTGCDNMTVICTTF
| .. |...|||.|.||||||. .....|||.||  |..| .  |... | | ||| ...  | |||||||.  ..
vlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvvivvl
PP2C Protein phosphatase 2C 313-468 2.9e-57 187.1 Pfam-A 98-250 (255) alignment 
Range on Protein: 313-468
Range on HMM: 98-250/255.0
EDSGTTACVCLVGKDKVIVANAGDSRAVLCRNGKAV-DLSVDHKPEDEVETNRIHAAGGQIE-DGRVNGGLNLSRAFGDHAYKKNQelglkEQMITALPD
..||.|| |.|. ..|..|||.|||||||||...|.  |..||||.|| |..|| .|||...  ||||| |..|||.||. .|...     ||...| ||
sksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePd

VKIEALTPEDEFIVVACDGIWNSMESQQVVDFVRDLLAKGSSCAEVCDALCDACLADS
|.   ||.||||...|.||.|. ...|..||.||. | |..|  |....|.| ..|  
vtsvklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiarg
PP2C Protein phosphatase 2C 313-468 2.9e-57 187.1 In-house 98-250 (255) alignment 
Range on Protein: 313-468
Range on HMM: 98-250/255.0
EDSGTTACVCLVGKDKVIVANAGDSRAVLCRNGKAV-DLSVDHKPEDEVETNRIHAAGGQIE-DGRVNGGLNLSRAFGDHAYKKNQelglkEQMITALPD
..||.|| |.|. ..|..|||.|||||||||...|.  |..||||.|| |..|| .|||...  ||||| |..|||.||. .|...     ||...| ||
sksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePd

VKIEALTPEDEFIVVACDGIWNSMESQQVVDFVRDLLAKGSSCAEVCDALCDACLADS
|.   ||.||||...|.||.|. ...|..||.||. | |..|  |....|.| ..|  
vtsvklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiarg
subfamily_PPM1A_pd Subfamily PPM1A 218-486 2.8e-56 183.9 In-house 81-280 (282) alignment 
Range on Protein: 218-486
Range on HMM: 81-280/282.0
GSPKKKGQKRCQKSPIQSEAKKSKSETDAETAPSSssgvdgvateeededdsdkefvadeeeddedaedeqsdeemvdgslaplllgsggaevpgedsGT
 |.|.. ..  ... .. . ......||..||  |                                                               |.
asekdevkealrqgfLaldeairelstdlktadks...............................................................Gs

TACVCLVGKDKVIVANAGDSRAVLCRNGKAVDLSVDHKPEDEVETNRIHAAGGQIEDGRVNGGLNLSRAFGDHAYKKNQELGLKEQMITALPDVKIEALT
|| ..|| ....|.||.|||||||||||||. |. ||||... |..||..|||..  .|||| | .|||.||..||...|.. .||...| |.|..   .
TavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDyeykeeeekkaeeqlvsaepevtsiers

PEDEFIVVACDGIWNSMESQQVVDFVRDLLAKGSSCAEVCDALCDACLADSTDgdgtgcDNMTVICTTF
 ||.|.|.||||||  .....||..||. | ...   ||..|| | .|   .       ||..|.  .|
eeddflvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsr......DNlsvlvvlf
PPM_PTC7 313-469 2.2e-55 180.9 In-house 99-255 (259) alignment 
Range on Protein: 313-469
Range on HMM: 99-255/259.0
EDSGTTACVCLVGKDKVIVANAGDSRAVLCRNGKAV-DLSVDHKPEDEVETNRIHAAGGQIE---DGRVNGGLNLSRAFGDHAYKKNQElglKEQMITAL
..||.|| |.|. ..|..|||.|||||||||.|.||  |..||||..| | .|| .|||...   .||||| |..||||||. .|...    .||...| 
stsGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpket...eeqlvsae

PDVKIEALTPEDEFIVVACDGIWNSMESQQVVDFVRDLLAKGsSCAEVCDALCDACLADST
||..  ....||||...|.||.|. ...|..||.||. |.|. .  |....|.| ..|. .
PdisstkideedefliLasdGlwdvvsdqeavdlvrselskk.dpmeaaeklvdeaiargs
0049733 PP2C-like 311-486 7.1e-41 133.1 In-house 88-233 (235) alignment 
Range on Protein: 311-486
Range on HMM: 88-233/235.0
PGEDSGTTACVCLVGKDKVIVANAGDSRAVLCRNGKAVDLSVDHKPEDEVETNRIHAAGGQIedgRVNGGLNLSRAFGDHAYKknqelglkeqmitalPD
.   .||||.|.|. ..|..|||.|||||.|.|.||.| |..||.| .| |  ||..||| .   ||.|.| |.||.||. .|               ||
elagmgtTavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav...rvpgrlaltralGdlllk...............pd

VKIEALTPEDeFIVVACDGIWNSMESQQVVDFVRDllakgSSCAEVCDALCDACLAdstdgdGTGCDNMTVICTTF
| .  |.|.| |...|.||.|. ......||..|.      .. |....|....||      . |.||.||..  .
vtvlelepgd.flllasDGlwdvlsdeeivdllrs.....ldleeaaerlvelala......rggrDNiTvvvvrl
subfamily_PPM1E_pd Subfamily PPM1E 314-486 2.2e-36 118.4 In-house 101-262 (265) alignment 
Range on Protein: 314-486
Range on HMM: 101-262/265.0
DSGTTACVCLVGKDKVIVANAGDSRAVLCRNGKAVDLSVDHKPEDEVETNRIHAAGGQI---EDGRVNGGLNLSRAFGDHAYKknqelglkeQMITALPD
 ||.|| |.|. ||.. ||  |||.|.|.|.|.|| |   ||||.| | .|| .|||..   .  |||| |..||| ||  .|         ..... .|
ksGstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklk.........pyvsgead

VKIEALTPEDEFIVVACDGIWNSMESQQVVDFVRDLLAKGS-SCAEVCDALCDACLADSTDgdgtgcDNMTVICTTF
|   .|. ..|....||||.|. .. ..||. |.. ||.|. . .||   |..|   .  .      ||.||.   .
vaeveldgseeylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagss......Dnitvvvvfl
subfamily_ILKAP_pd Subfamily ILKAP 311-449 3e-33 108.2 In-house 109-245 (293) alignment 
Range on Protein: 311-449
Range on HMM: 109-245/293.0
PGEDSGTTACVCLVGKDKVIVANAGDSRAVLCRNGKA------VDLSVDHKPEDEVETNRIHAAGGQIEDGRVNGGLNLSRAFGDHAYKKnqeLGlkeqm
|    |.|| |.||  . . ||| |||.|||.|. ..      | |..||.| .. | .||. |||...||||.| |. ||. ||  .|.   ||     
PvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfkr...lG.....

ITALPDVKIEALTPEDEFIVVACDGIWNSMESQQVVDFVRDLLAK
... ||||   ||. | |.|.||||.|.... ..||.|. ..| .
vistPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvled
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 314-468 1.1e-31 103.0 In-house 94-241 (255) alignment 
Range on Protein: 314-468
Range on HMM: 94-241/255.0
DSGTTACVCLVGKDKVIVANAGDSRAVLC-RNGKAVDLSVDHKPEDEVETNRIHAAGGQIEDG----RVNGGLNLSRAFGDHaYkknqelglKEQMITAL
  |||| . |. .|||..|| ||||.||| ..| |. ||.|||| .| |..||...||..  .    |||| | .|||.||  .         |  ... 
fiGttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGds.f........lePfvvpd

PDVK-IEALTPEDEFIVVACDGIWNSMESQQVVDFVrdllAKGSSCAEVCDALCDACLADS
||..     . .|.|...||||||. .  .. |. |    |. |.  . .  | |      
PdlsqsleiskkdkflilacdGiwdlisdeeaveiv....agisdpekaaeklrdlayssG
subfamily_PPM1K_pd Subfamily PPM1K 311-457 1.2e-28 92.9 In-house 94-239 (263) alignment 
Range on Protein: 311-457
Range on HMM: 94-239/263.0
PGEDSGTTACVCLVGK-DKVIVANAGDSRAVLCRNGKAVDLSVDHKPEDEVETNRIHAAGGQIE-----DGRVNGGLNLSRAFGDhaykknqeLGLKEQM
  . ||||| |.|. .  ....|. |||||.|||||||  |. ||.|| | | .||.||||..|       .||| | ..|..||        | ||.  
ellssGttatvsllrdGtelvlaslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGd........ldlkryG

ITALPDVKIEAL-TPEDEFIVVACDGIWNSMESQQVVDFVRDLLAKGSSCAEVC
. | |. |   .   .| |.|.  ||| . ..||.. |.||       .   ..
viatPetkslkvdhaadsflvlitdgisfvvnsqelcdlvrlchdpeeaahalt
PPM_PTC7_SpoIIE 313-461 3.3e-28 92.0 In-house 89-218 (230) alignment 
Range on Protein: 313-461
Range on HMM: 89-218/230.0
EDSGTTACVCLVGKDK--VIVANAGDSRAVLCRN-GKavdlsvdhkpedevETNRIhAAGGQIE----DGRVNGGLNLSRAFGDHAYKKnqelglKEQMI
..||.||.|.|.  ..  . |||||||...|.|. |.              |  || .||| ..    .|||.| |..|.|.||  ..       .....
sssgaTavvalidpstgklyvanaGdsppllvrddgg..............ereri.vagglpslGilpgrvfgvlavslapGdlllly......tDGvv

TALPDvKIEALTPE-DEFIVVACDGIWNSMESQQVVDFVRDLLAKGsscaeVCDALC
.| ||  .. .... |||...|.||.|. ...|..||.||| | |      ....| 
eaepd.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp.....aaegll
subfamily_PPM1L_pd Subfamily PPM1L 313-450 2.8e-27 88.6 In-house 104-239 (269) alignment 
Range on Protein: 313-450
Range on HMM: 104-239/269.0
EDSGTTACVCLVGKDKVIVANAGDSRAVLC-RNGKAVDLSVDHKPEDEVETNRIHAAGGQIE---DGRVNGGLNLSRAFGDHAYKKnQelglkeQMITAL
. .|||| . || ....|||| |||| ||. ..|||. || ||||..  |  ||. ||| |      ||.| |  |||.||.  |. .      ... | 
diaGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkd.k......nlviad

PDVKIEAL-TPEDEFIVVACDGIWNSMESQQVVDFVRDLLAKG
||.    |   . ||...|.||.|...  .. | |... | . 
pdiltfdlddhkpeflilasdGlwdtfsneeavrfikerlkep
subfamily_KAPP-like_pd Subfamily KAPP-like 313-484 7e-26 83.8 In-house 98-264 (266) alignment 
Range on Protein: 313-484
Range on HMM: 98-264/266.0
EDSGTTACVCLV---GKDKVI-VANAGDSRAVLCRNGKAVDLSVDHKPEDEVETNRIHAAGGQIEDG--RVNgGLNLSRAFGDHaYKKNQELGLKEQMIT
|  |.|| ..||   |. . . ||| ||| | |.|  ... || ||| .|. |  ||.  |  . |.  |.| || .|||.||| . |....||  .   
eyeGatatlalvwsdGqqrylqvanvGdssaflsrGneslelskdhkakdpeekqrikddGitlsdnqtrin.GlavsralGdh.fikelniGlisepyv

ALPdvkiEALTPEDEFIVVACDGIWNSMESQQVVDFVRDLLAKGSSCAEVCDALCDACLADStdgdgTGCDNMTVICT
. .     .||| |.|..|| ||.|. .. .. .. |. |  ....  .....| .. .  .        ||..||  
snr....illtpfdkflivasdGlwdvisGkdaiekvkslydqqatedkmasslletaiqsi.....kakdnvsvivv
subfamily_PDP_pd Subfamily PDP 313-455 7.3e-26 84.2 In-house 150-320 (398) alignment 
Range on Protein: 313-455
Range on HMM: 150-320/398.0
EDSGTTACVCLVGKDKVIVANAGDSRAVLCRN---G--KAVDLSVDHKPEDEVETNRIHAAGGQIED------GRVNGGLNLSRAFGDHAYKKNQELGL-
  ||..|.. |. .... |||.||.||||...   |  .|| || |.  . | | .||...  . |.      ||. | |  .|||||  || ..||   
alsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirngRlLgeLqPlRAFGdvryKwseelqkk

--KE-------Q-------MITALPDVKIEALTPEDEFIVVACDGIWNSMESQQVVDFVRDLLAKGSSCAE
  ..                .|| |.|    |...| |.|.| ||.|.......||. | . |||  . ..
vlekaylkvlepkdyktPPYltaePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkkekep
subfamily_PPM1G2_pd Subfamily PPM1G2 5-110 1e-24 80.0 In-house 2-112 (287) alignment 
Range on Protein: 5-110
Range on HMM: 2-112/287.0
LNKPIIEKEKEEGSGNGLSYACTTMQGWRVNQEDAHNC---VVDLH--TDWHMFGVYDGHGGTEVSKFTSAKLPDFLKERKFWEADDVAECLQKAFVDFD
|..|...||.. .. .    . ..|||.|.|.||||     .....  ..  .|.|.|||||..|.|... ||  .....| .. . . ..|..||...|
lsepvvakesascanaltkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdafletD

DFIRAEESMKE
  .. .|..|.
eellkdeklkd
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 315-484 5e-24 77.6 In-house 104-274 (276) alignment 
Range on Protein: 315-484
Range on HMM: 104-274/276.0
SGTTACVCLVGKDK----------VIVANAGDSRAVLCRNGKAVDLSVDHKPEDEVETNRIHAAGGQIEDG--RVNgGLNLSRAFGDHaYKKNQELGLKE
 |.|| ..|| .|           . ||| ||| | |.|  ... || ||| .|  | .||.  |  . |.  |.| || .|||.||| . |....||  
eGatatlalvwsdGeeqqqqqqrylqvanvGdssaflsrGneslelskdhkatdpeekqrikddGitlsdnqtrin.GlavsralGdh.fikelniGlis

QMITALPdvkiEALTPEDEFIVVACDGIWNSMESQQVVDFVRDLLAKGSSCAEVCDALCDACLADStdgdgTGCDNMTVICT
.   . .     .||| |.|..|| ||.|. .. .. .. |. |  ....  .....| .. .  .        ||..||  
epyvsnr....illtpfdkflivasdGlwdvisGkdaiekvkslydqqatedkmasslletaiqsi.....kakdnvsvivv
subfamily_PP2D1_pd Subfamily PP2D1 323-450 1.9e-21 69.4 In-house 184-311 (492) alignment 
Range on Protein: 323-450
Range on HMM: 184-311/492.0
LVGKDKVIVANAGDSRAVLCRNGKAVDLSVDHKPEDEVETNRIHAAGGQIE----DGRVNGGLNLSRAFGDHAykknqELGLKEQMITAlPDVKIEALTP
|. .  . .||||. .|||||.|||. |  .| |... | .|.. ||. .      |.||| |.  |  | .      .. ||. .|.. | ..   |. 
leelgvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyG.....dpkLkksvipe.Pkttsvklde

EDEFIVVACDGIWNSMESQQVVDFVRDLLAK--G
.. |.|.|  |.|. .. ..|.  |...||    
aaqflvlAsnGlWevlseeevlsLvkqtlaiyks
subfamily_PPM1A_pd Subfamily PPM1A 12-110 9.3e-20 64.1 In-house 2-110 (282) alignment 
Range on Protein: 12-110
Range on HMM: 2-110/282.0
KEKEEGSGNGLSYACTTMQGWRVNQEDAHNCVVDLHT--DWHMFGVYDGHGGTEVSKFTSAKLPDFLKE-RKFW-------EADDVAECLQKAFVDFDDF
| |....|||| |.  .||||||. ||||..|..| .  || .| |.|||.|.||.|... .|.. . |  ..        |.|.| | |...|...|. 
kpksqaegnglrygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldea

IRAEESMKE
||.... ..
irelstdlk
subfamily_TAB1_pd Subfamily TAB1 315-436 3.2e-16 52.0 In-house 129-262 (333) alignment 
Range on Protein: 315-436
Range on HMM: 129-262/333.0
SGTTACVCLVGKDKVIVANAGDSRAVLCR---NGKAVDLSVDHKPEDEVETNRIHAAGG---QIEDGRVNGGLNLSRAFGDHAYK----KNQELG-LKEQ
 |||| | |.  .|. |||.|||||.|..   . | . |||||. . | |  |..  |    ||.  .. |. .  |. ||.  |     .. |   |..
gGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkkgykdvdilssakge

MITALPDVKIE-ALTPEDEFIVVACDGIWNSMES
 . | ||..    ...   |.|.  ||. ...| 
PviaePdiqgaypiddityflvlmSdGvyktLee
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 314-379 3.8e-16 52.5 In-house 83-155 (292) alignment 
Range on Protein: 314-379
Range on HMM: 83-155/292.0
DSGTTACVCLVGKDK--VIVANAGDSRAVLCR-----NGKAVDLSVDHKPEDEVETNRIHAAGGQIEDGRVNG
 |.||| || . .|   .|.|| |||||.| |     . . . || ||||||  | .|| .|||..|  || |
esattavvcarvrddralilanvGdsrallgrclggsdyeliPlsrdhkPedPderarilraGGrveptrvrg
PP2C Protein phosphatase 2C 24-110 2.9e-13 43.0 Pfam-A 3-96 (255) alignment 
Range on Protein: 24-110
Range on HMM: 3-96/255.0
YACTTMQGWRVNQEDAHNCVV-----DLHTDWHMFGVYDGHGGTEVSKFTSAKLPDFLKERKFWEAD-DVAECLQKAFVD-FDDFIRAEESMKE
.  ...||.| . |||| .       .   ....|.|.|||||.|..|... .|...|||.|  . . .| ..|.|.|   .|. .. .. ..|
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskante
PP2C Protein phosphatase 2C 24-110 2.9e-13 43.0 In-house 3-96 (255) alignment 
Range on Protein: 24-110
Range on HMM: 3-96/255.0
YACTTMQGWRVNQEDAHNCVV-----DLHTDWHMFGVYDGHGGTEVSKFTSAKLPDFLKERKFWEAD-DVAECLQKAFVD-FDDFIRAEESMKE
.  ...||.| . |||| .       .   ....|.|.|||||.|..|... .|...|||.|  . . .| ..|.|.|   .|. .. .. ..|
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskante
0049733 PP2C-like 22-105 3.1e-13 42.9 In-house 3-82 (235) alignment 
Range on Protein: 22-105
Range on HMM: 3-82/235.0
LSYACTTMQGW-RVNQEDAHNCvvdlhtDWHMFGVYDGHGGTEVSKFTSAKLPDFLKER-KFWEADDVAECLQKAFVDFDDFIRAE
||.......|. | ..|||. .      ....|.|.||||| ..... |  |...|.|  . ..  |..|.|.|||   .. ....
lsvgaasdigrvrkvneDavlv......glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallel
subfamily_PHLPP_pd Subfamily PHLPP 316-445 3.9e-13 41.9 In-house 86-214 (246) alignment 
Range on Protein: 316-445
Range on HMM: 86-214/246.0
GTTACVCLVGKDK--------VIVANAGDSRAVLCRNGKAVDLSVDHKPEDEvETNRIHAAGGQI-EDGRVNGGLNLSRAFGdHAYKKnqelglkeQMIT
|..| ..|. .||        . ||. |   |||.|||| . ||  .. |.. | .||. | . | ||...|| .. .| .| . .           .. 
gsaallilirhdkvdPaksfsLevAsvGtlqavliRngkklrlsksyviekd.elkrikeakaiitednkingviestrllG.ytflf........Pvvl

ALPDVKIEALTPEDEFIVVACDGIWNSMESQQVVDFVRD
  | |.   ||..||...|  . .|.... ...|. ||.
PkphvrevlLteqdellivGnkalWevlsideaveavrk
PPM_PTC7 25-108 5.2e-13 42.0 In-house 4-95 (259) alignment 
Range on Protein: 25-108
Range on HMM: 4-95/259.0
ACTTMQGWRVNQEDAHNCVV-----DLHTDWHMFGVYDGHGGTEVSKFTSAKLPDFLKERKFWEAD-DVAECLQKAFVD--FDDFIRAEESM
  . .||.|.. |||| .       .   ... |.|.|||||.|..|... .|...|||||  | . .. ..| |.|    .|. .. .| .
gasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelkssean
subfamily_PPM1H_pd Subfamily PPM1H 315-360 1.1e-12 40.5 In-house 162-207 (404) alignment 
Range on Protein: 315-360
Range on HMM: 162-207/404.0
SGTTACVCLVGKDKVIVANAGDSRAVLCRNGKAVDLSVDHKPEDEV
 | ||.| || ..|. |||||||||.|.|... ..|| |. || | 
GGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftPeteR
subfamily_PPM1D_pd Subfamily PPM1D 315-374 3.1e-12 39.2 In-house 108-173 (309) alignment 
Range on Protein: 315-374
Range on HMM: 108-173/309.0
SGTTACVCLVGKDKVIVANAGDSRAVLCRNGK------AVDLSVDHKPEDEVETNRIHAAGGQIED
.|||| | .. ..|. ||. |||..||  . .      |  | .|||||.  |..||. .||.. .
aGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaa
PP2C_SIG_SM00331 313-483 3.5e-12 39.3 In-house 84-214 (217) alignment 
Range on Protein: 313-483
Range on HMM: 84-214/217.0
EDSGTTACVCLV--GKDKVIVANAGDSRAVLCRNGKAVDLSVDhkpedevetnrihaaggqiedgrvngglnlsrafgdhayKKNQELGLKEQMItalPD
.....|....|.   ..|. .||||||| .| |.|| |    |                                       .. . |||...     .|
kgmfaTlllalydfssgklsyanaGdsrpyllrdgklveilkd.......................................vegaplGlepevs...vd

VKIEALTPeDEFIVVACDGIWNSMES-----QQVVDFVRDLLakGSSCAEVCDALCDACLADSTDGDGtgCDNMTVIC
..   | . ..... . ||... ...     ... ....||.  .|...|. ..  .  |. ...  |   |..||. 
irelelek.gdllllytDGltearsekgfaeerleeiledlv..dseaqelaqkiveellelakgsng..eDdiTvvv
PPM_PTC7_motif 424-470 5.1e-12 39.1 In-house 1-48 (51) alignment 
Range on Protein: 424-470
Range on HMM: 1-48/51.0
VVACDGIWNSMESQQVVDFVRDLLA-KGSSCAEVCDALCDACLADSTD
. |.||.|. ...|..||.||| |. || |  |..  |.| .||  ..
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargse
PPM_PTC7_SpoIIE 26-98 4.4e-11 36.0 In-house 5-80 (230) alignment 
Range on Protein: 26-98
Range on HMM: 5-80/230.0
CTTMQGWRVNQEDAHNCVV-----DLHTDWHMFGVYDGHGGTEvsKFTSAKLPDFLKERKFWEADDVAECLQKAFVDF
 . .||.| . |||| .       . .  . ..|..||||| .  ..... | ..|.|..| ......|.|....  .
asaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrelafaglekpeeilrrlnlal
subfamily_PPM1D_pd Subfamily PPM1D 381-487 9.6e-11 34.3 In-house 201-308 (309) alignment 
Range on Protein: 381-487
Range on HMM: 201-308/309.0
LNLSRAFGDH-AYKKNQelglKEQMITALPDVKIEALTPEDE-FIVVACDGIWNSMESQQVVDFVRDLLAKGSSC----AEVCDALCDACLADsTDGDGT
|...|. ||  .|....    .| ..   ||||   |.|..| ||..| ||.|| ......|..|..  .|..       .|  || .  |   .     
LavaRslGDlWsynaks....gefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqr.wrskkl

GCDNMTVICTTFD
 .||..||. ...
raDnvsvivvile
subfamily_PPM1H_pd Subfamily PPM1H 374-450 4.2e-10 31.9 In-house 274-354 (404) alignment 
Range on Protein: 374-450
Range on HMM: 274-354/404.0
DGRVNGGLNLSRAFGDHAYKKNQ-ELGLKeQMITALPDVKIEALT----PEDEFIVVACDGIWNSMESQQVVDFVRDLLAKG
  |. . .  .| .|||  |  . .| .|  .... |.|..  ||     ||. ...| ||.|. .. ..|   ||..|.| 
kaRllatigvtRGlGDheLkvvdtnlsik.PfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskv
subfamily_PPM1D_pd Subfamily PPM1D 27-102 6.3e-10 31.6 In-house 7-90 (309) alignment 
Range on Protein: 27-102
Range on HMM: 7-90/309.0
TTMQGWRVNQEDAHNCVVDL-----HTDWHMFGVYDGHGGTEVSKFTSAKLPDFLKE-RKFWEA--DDVAECLQKAFVDFDDFI
.. || |   ||    |..      . .. ...|.||||| | .||.. .|  ..|. .||.    .|| | ...||..    .
eadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheam
subfamily_PPM1K_pd Subfamily PPM1K 26-102 8.6e-10 31.2 In-house 8-82 (263) alignment 
Range on Protein: 26-102
Range on HMM: 8-82/263.0
CTTMQGWRVNQEDAHnCVVDLHTDWHMFGVYDGHGGTEVSKFTSAKLPDFLKERKfWEADDVAECLQKAFVDFDDFI
. ...| | . ||   .. .|. .   ..|.|||.|.   .|.  ||   ||. .  . .|. . |..|| . |. .
kdsliGkraenedri.klkeldpellyvavfdGhaGsaaadfvhdklekilkrll.ekekdleivlknafeeldkkl
subfamily_PPM1E_pd Subfamily PPM1E 26-105 1.9e-09 30.1 In-house 8-94 (265) alignment 
Range on Protein: 26-105
Range on HMM: 8-94/265.0
CTTMQGWRVNQEDAHNCVVDLH--------TDWHMFGVYDGHGGTEVSKFTSAKLPDFLKERKFWEaDDVAECLQKAFVDFDDFIRAE
 ..... |  .|| | .. ||         ..  .|.|.|||||.| .|...|.|. .| ...  . .| || |..||   |. . . 
iaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklk.edpaealkeafkltDerflqk
subfamily_Choan-PPM-1_pd Subfamily Choan-PPM-1 314-474 1.4e-08 26.4 In-house 133-309 (317) alignment 
Range on Protein: 314-474
Range on HMM: 133-309/317.0
DSGTTACVCLV-GKDKVIVANAGDSRA--VLC-------RNGKAVD-LSVDHKPEDEVETNRIHAAGGQIEDGRVNGGLN-LSRAFGDHAYKKNQELG--
| |||| | .|  . .|.||||||. |  .|        |.|  |. ||| |. . . | .|.. . ..      .| |  |  |. ..  .  . ||  
dfGttavvavvvdethvvvanaGdaaalvllrdqaghedrdGlsvealsvrhtlrskaerarvaevlpgaahvtedgylaildealaayelqltkslGhk

-LKEQMITALPDVKIEALTPEDEFIVVAC-DGIWNSMESQQVVDFVRDLLAKGSSCAEVCDALCDACLADSTDGDGT
 ||   ..| |.|. ..|  .. | ||.. ||| . .. ..|.| |    .   ..  .||   | .|. ..  | |
llkraGviadPevrsrvldvdevfavvvvsdGitdelkrldvldrvlraataleasevlcddaqdylldetsiddat
Subfamily Dicty-PPM1L-like 329-395 2.2e-08 26.3 In-house 229-291 (305) alignment 
Range on Protein: 329-395
Range on HMM: 229-291/305.0
VIVANAGDSRAVLCRNGKAVDLSVDHKPEDEVETNRIHAAGGQIEDGrVNGglnLSRAFGDHAYKKN
  ||.|.|.. ||...|..  || ....|.  |  |..  ...||    |    .||  .  |.|..
lvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewd.fne...isrviveeavkrg
PPM_PTC7_SpoIIE_motif 418-485 1.8e-07 24.7 In-house 10-79 (81) alignment 
Range on Protein: 418-485
Range on HMM: 10-79/81.0
PEDEFIVVACDGIW-------NSMESQQVVDFVRDLlaKGSSCAEVCDALCDACLAdstDGDGTGCDNMTVICTT
.... .....||..       . .. .........   .| | .|..|.|.|..|.    |.|   |..|...  
kpgdvllLyTDGltEardsdgelfgkeellrladra..egkslqeladklvdevle...ngsgereDDitllvlr
PP2C_2 Protein phosphatase 2C 309-449 2.7e-07 23.1 Pfam-A 91-197 (212) alignment 
Range on Protein: 309-449
Range on HMM: 91-197/212.0
EVPGEDSGTTACVCLVGKDKVIVANAGDSRA-VLCRNGKAVDLSVDHKPEDEVETNRIHAAggQ----Iedgrvngglnlsrafgdhaykknqelglkeq
. . .| .|| ..... ........ ||... |  |.|..  |. ... | . ||...  .  .                                    
qeelkdyatTlllavitpgeivffqiGDgaivvrdrdgevqllgepdsgeyanettfltse..daeeel...............................

mitalpdvKIEALT-PEDEFIVVACDGIWNSMESQQ-VVDFVRDLLAK
        .|. |. .. . ...  ||...|..... . .....||..
........rirrlklepgdalllmTDGvsdslrkeepfrellaellet
PP2C_2 Protein phosphatase 2C 309-449 2.7e-07 23.1 In-house 91-197 (212) alignment 
Range on Protein: 309-449
Range on HMM: 91-197/212.0
EVPGEDSGTTACVCLVGKDKVIVANAGDSRA-VLCRNGKAVDLSVDHKPEDEVETNRIHAAggQ----Iedgrvngglnlsrafgdhaykknqelglkeq
. . .| .|| ..... ........ ||... |  |.|..  |. ... | . ||...  .  .                                    
qeelkdyatTlllavitpgeivffqiGDgaivvrdrdgevqllgepdsgeyanettfltse..daeeel...............................

mitalpdvKIEALT-PEDEFIVVACDGIWNSMESQQ-VVDFVRDLLAK
        .|. |. .. . ...  ||...|..... . .....||..
........rirrlklepgdalllmTDGvsdslrkeepfrellaellet
Subfamily Dicty-PPM1L-like 24-74 7.6e-07 21.2 In-house 9-61 (305) alignment 
Range on Protein: 24-74
Range on HMM: 9-61/305.0
YACTTMQGWRVNQEDAHNCVVDLHT--DWHMFGVYDGHGGTEVSKFTSAKLPD
|     .. | .||| ..  . |    .  .|||.|||.|   ....  || .
yelyvsansrkyqedrnkvkislessqelslfGvfdGhnGdiaaeyvkkklve
Subfamily Dicty-PPM1L-like 376-452 1.2e-06 20.6 In-house 200-268 (305) alignment 
Range on Protein: 376-452
Range on HMM: 200-268/305.0
RVNGGLNLSRAFGDHaykknqelGLKEQMItALPDVKIEAL-TPEDEFIVVACDGIWNSMESQQVVDFVRDLLAKGSS
.||. |. ||  ||         .||| .|   .| ..  .  ..|.|.|.| ||.|. .. |.||..|..|| . ||
lvnrllkksrskGdk........nlkelvi.PnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkss
subfamily_PDP_pd Subfamily PDP 37-78 3.6e-06 19.3 In-house 12-53 (398) alignment 
Range on Protein: 37-78
Range on HMM: 12-53/398.0
EDAHNCVVDLHTDWHMFGVYDGHGGTEVSKFTSAKLPDFLKE
|| .  .  |...  .||| |||||.  ..  | .|....  
EDrrseakllesngvlfgvfDGHggaacaeavskrLlkyvaa
Drc1-Sld2 DNA replication and checkpoint protein 159-292 4.7e-06 12.2 Pfam-A 257-382 (426) alignment 
Range on Protein: 159-292
Range on HMM: 257-382/426.0
GKSLLSAFLAKGDVSDDSEDEDED---EEEAEEQ--DDTEEKKENEDASaevvienaedKEEEEGSPKKKGQKRCQKS-PIQSEAKKSKSETDAETAPSS
||.| . . .  |. ... ||. |   |.||||.  .. ||..|...|.          .|||.  .|||||||  .   ..   ||...|.  |.. ..
gKgLselvqgLrdmeeekldeeldvlreieaeeaegkpeeeeeedsqaa..........eeeetrvfkkkgqKRttRrvkmrpvrkkpeeepaleesdie

SSGvdgvateEEDEDDSDKEFVADEEEDD---EDAEDEQSDEE
..        . ....| .|.....|. .   ||...|.|.||
eee.......kklkekslsellkeaegeeeqeedekkeaskee
subfamily_PPM1L_pd Subfamily PPM1L 26-80 8.5e-06 18.2 In-house 9-65 (269) alignment 
Range on Protein: 26-80
Range on HMM: 9-65/269.0
CTTMQGWRVNQEDAHNCVVDLH--TDWHMFGVYDGHGGTEVSKFTSAKLPDFLKERK
  ...| | . ||  .   |..  |. ..|.|.|||||   ..|.  .|.. .|.. 
vysvlGrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknkl