Gene F43C1.1 in Caenorhabditis elegans

Synonym: CELE_F43C1.1, F43C1.1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PHLPP
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP085_AA protein Get Run
CeleP085_AA_657-894 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PHLPP_pd Subfamily PHLPP 666-896 2.6e-107 350.3 In-house 1-244 (246) alignment 
Range on Protein: 666-896
Range on HMM: 1-244/246.0
NLFGFQIGVSGSRGMKNKQCIRQVRVENTFGFIDGGSNSYMSSSICRFMTSYLKENVSMD------IRSILLRCHCELGEEGERLGASVMIIRV-HEK--
||..|.||.|.|.|.|||.|.....||...|..||..|...||...|.|...|||.|..|      ....||.....|||.||.||.....|.. |.|  
nlavfsiGlsesaGvknklcvaalsvealyGlfdGdrneelssllqrlmkdvlkeevqkdkneeeymkntllvaqrklGeaGeklgsaallilirhdkvd

-----RLEIASTGTMSAAIARNQKlKMIINGRYEIDDDEYSRIREAHGFVDEENRINGVIGSSRQIGHFSTFPVVLPTHSYRNIQLNEQIEGLIVGNNMI
     .||.||.||..|...||.| |......|.|..||..||.||.....|.|.|||||.|.|..|....||||||....|...|.||.|.|||||...
PaksfsLevAsvGtlqavliRngk.klrlsksyviekdelkrikeakaiitednkingviestrllGytflfPvvlPkphvrevlLteqdellivGnkal

WNMLSIDDLNSTFHNNRSPIVVAKKIQDQLQSYDYGGNSNILVLR
|..||||...........|.|.|||..|..|||........||.|
WevlsideaveavrkeedplvaAkklvdlaqsygaadsvsvlvvr
0034914 PP2C-like 658-894 1.1e-20 66.8 In-house 9-285 (295) alignment 
Range on Protein: 658-894
Range on HMM: 9-285/295.0
INISEGSQNLFGFQIGVSGSRGMKNKQCIRQVRVEN---------TFGFIDGGSNSYMSSSICRFMTSYLKE--------------NVSMDIRSILLRCH
...   |  |. ...||.  .|.....  . . | |          ||  || ......  ... . ..|.|              ..   .|...|...
lellllsslllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaad

CELGEEGER------LGASVMIIRVHEKRLEIASTGTMSAAIARNQKLKMIINGRYEIDDDEYSRIREAHGFVDEeNRINGVIGSSRQIGHFSTF-----
 || |....       |... .. .....| .| .|   | . ||..|... .     . .|. ||..|.|.|   .|.|||.  .| .|.|. .     
eellelallrpelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavsh.grvngvlavtRalGdfdlklllsl

----PVVLPTHSYRNIQLN-EQIEGLIVGNNMIWNMLSIDDLNSTFHN----NRSPIVVAKKIQDQlqSYDYGGNSNILV
    |.| ..  .. ..|. |. . |...   .|..|| ... .  ..    . .. ..|... |.  ....|.  || |
llleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdl..AlargsrDNiTv
PP2Cc_SM00332 695-894 2.2e-19 62.9 In-house 43-271 (274) alignment 
Range on Protein: 695-894
Range on HMM: 43-271/274.0
FGFIDGGSNSYMSSSICRFMTSYLKENVS-----------MDIRSILLRCHCELGEEGER-------LGASVMIIRVHEKRLEIASTGTMSAAIARNQKL
||  || . | ..  ... ....|||. .             ... .|... |. || ..        |...... .....| .|..|   | ..||.| 
fgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskelenalsGstavvallkkedlyvanvGDSravlcrngka

KMIINGRYEIDDDEYSRIREAHGFVDEEnRINGVIGSSRQIGHFSTF-------PVVLPTHSYRNIQLNEQIEGLIVGNNMIWNMLSIDDLNSTFHNNR-
... .     | ||..||..|.|.|  . |.||.. .||..| .          |.. .. .   ..|... | ||.    .|..|| ... .. .. . 
vqlsvdhkpedederkRikkaggvvekg.rvngglavsrafGdhflkknkklkepyitaepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrklla

-----SPIVVAKKIQDQLQSYdYGGNSNILV
     .|  .|... ......  |.. || |
kgktndpqeaaelldeeairr.ggseDniTv
PP2C Protein phosphatase 2C 745-884 5.7e-17 55.1 Pfam-A 101-249 (255) alignment 
Range on Protein: 745-884
Range on HMM: 101-249/255.0
GASVMIIRVHEKRLEIASTGTMSAAIARNQKLK-MIINGRYEIDDDEYSRIREAHGFVDEENRINGVIGSSRQIGHFSTFP----VVLPTHSYRNIQLNE
|.. ... . .|.| .| .|.  | ..|... | .. .     |.||..||.||.|.|....|.||..  || .| |  .|    .| .    . ..|.|
GstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpkeeqlvsaePdvtsvklte

QIEGLIVGNNMIWNMLSIDDLNSTFHNNRS----PIVVAKKIQDQLQSY
. | ||...  .|..|| ... .  ....|    |  .|... |. ...
edefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiar
PP2C Protein phosphatase 2C 745-884 5.7e-17 55.1 In-house 101-249 (255) alignment 
Range on Protein: 745-884
Range on HMM: 101-249/255.0
GASVMIIRVHEKRLEIASTGTMSAAIARNQKLK-MIINGRYEIDDDEYSRIREAHGFVDEENRINGVIGSSRQIGHFSTFP----VVLPTHSYRNIQLNE
|.. ... . .|.| .| .|.  | ..|... | .. .     |.||..||.||.|.|....|.||..  || .| |  .|    .| .    . ..|.|
GstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpkeeqlvsaePdvtsvklte

QIEGLIVGNNMIWNMLSIDDLNSTFHNNRS----PIVVAKKIQDQLQSY
. | ||...  .|..|| ... .  ....|    |  .|... |. ...
edefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiar
PPM_PTC7 748-884 1.1e-13 44.2 In-house 106-253 (259) alignment 
Range on Protein: 748-884
Range on HMM: 106-253/259.0
VMIIRVHEKrLEIASTGTMSAAIARNQKLK-MIINGRYEIDDDEYSRIREAHGFVD--EENRINGVIGSSRQIGHFSTFP------VVLPTHSYRNIQLN
|... ...| |..| .|.  | ..|... . .  .     . ||..||..|.|.|.  ...|.|||.  || .| |  .|      .| ..     ....
vvalitgsk.lyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpketeeqlvsaePdisstkid

EQIEGLIVGNNMIWNMLSIDDLNSTFHNNRS---PIVVAKKIQDQLQSY
|. | ||...  .|...| ... .  ....|   |  .|.|. |  ...
eedefliLasdGlwdvvsdqeavdlvrselskkdpmeaaeklvdeaiar
LRR_4 Leucine Rich repeats (2 copies) 244-283 5e-13 38.3 Pfam-A 2-41 (44) alignment 
Range on Protein: 244-283
Range on HMM: 2-41/44.0
RLQYLNLSNNQLDTLPDSISELQNLQSLDISFNQFSQIPP
 |..|.||||..  || ... |.||..|..| |..| ...
nLevLdLsnNnIkdlppelanLpnLktLnLsnNpisdlsa
LRR_8 Leucine rich repeat 198-255 9e-13 37.4 Pfam-A 2-61 (61) alignment 
Range on Protein: 198-255
Range on HMM: 2-61/61.0
SLQVIDLSANQILSFPI-QLTLLSHLRQLNLSSNYISSVPSEC-SNMRRLQYLNLSNNQL
.|...||| |.. . |   .  ||.|..|.||.| ..|...|. .....|..||||.|.|
nLkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkgLpsLreLnLsgNrl
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 703-895 1.2e-12 40.6 In-house 51-249 (255) alignment 
Range on Protein: 703-895
Range on HMM: 51-249/255.0
NSYMSSSICRFMTSYLKENVS---MDIRSILLRCHCELGEEGERLGASVMIIRVHEKRLEIASTGTMSAAIA-RNQKLKMIINGRYEIDDDEYSRIREAH
 .. |  . . ....|. | .     ..      .  ..| . ..|.. . . . |..  ||  |   . .. ..   | .       ...|  ||.|. 
akfaseelykilaelldlnnanPvkslkkaykeistqiserpkfiGttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselG

GFVDEE---NRINGVIGSSRQIGHFSTFPVVLPTHSYR-NIQLNEQIEGLIVGNNMIWNMLSIDDLNSTFHNNRSPIVVAKKIQDQlqSYDYGGNSNILV
|.| ..    |.|| .  || .|     | |.|      ...  .. . ||.  . ||...| ..  ..  .  .|   |.|..|.  .|  | . || |
GtvvstvvtsrvnGtlavsralGdsflePfvvpdPdlsqsleiskkdkflilacdGiwdlisdeeaveivagisdpekaaeklrdl..ayssGstdnisv

L
.
i
LRR_8 Leucine rich repeat 535-593 1e-11 34.0 Pfam-A 2-61 (61) alignment 
Range on Protein: 535-593
Range on HMM: 2-61/61.0
HLKIIDLSHNRLNSFDDSALSSLELLEDLNLSSNRLTRLAD-CLALLPCLQVLRAHSNQL
.|| .|||.||| . .......|. |. |.||.|.|... . ... || |. |  ..|.|
nLkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkgLpsLreLnLsgNrl
subfamily_PPM1E_pd Subfamily PPM1E 740-865 1.8e-11 36.8 In-house 98-225 (265) alignment 
Range on Protein: 740-865
Range on HMM: 98-225/265.0
EGERLGASVMIIRVHEKRLEIASTGTMSAAIARNQKLKMIINGRYEIDDDEYSRIREAHGFVD--EENRINGVIGSSRQIGHFSTFPVVLPTHSYRNIQL
|. . |.  ... .....| .|  |   |.. |...   ....    ..|| .|| || |.|   .. |.|||.  || ||  .. | |       ...|
eklksGstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklkpyvsgeadvaevel

NEQIEGLIVGNNMIWNMLSIDDLNSTFH
... | ||.. . .|...  ... .. .
dgseeylilacDGlwDvvneeevvklve
LRR_4 Leucine Rich repeats (2 copies) 395-431 1.8e-09 26.9 Pfam-A 2-38 (44) alignment 
Range on Protein: 395-431
Range on HMM: 2-38/44.0
NLQTLSLSFNHFRNLPDWISDCPNLTFLRANNNSLVA
||..|.|| |   .|| ... .|||. |  .|| .  
nLevLdLsnNnIkdlppelanLpnLktLnLsnNpisd
LRR_4 Leucine Rich repeats (2 copies) 464-499 1.6e-08 23.9 Pfam-A 3-37 (44) alignment 
Range on Protein: 464-499
Range on HMM: 3-37/44.0
LETLILYKNKLSSLPKHFFSiLPRLRQLNISSNFIE
||.| | .|....|| .. . || |..||.|.| |.
LevLdLsnNnIkdlppelan.LpnLktLnLsnNpis
subfamily_PPM1A_pd Subfamily PPM1A 741-867 2e-08 26.9 In-house 112-246 (282) alignment 
Range on Protein: 741-867
Range on HMM: 112-246/282.0
GERLGASVMIIRVHEKRLEIASTGTMSAAIARNQKLKMIINGRYEIDDDEYSRIREAHGFVDeENRINGVIGSSRQIGHFSTFP---------VVLPTHS
 .. |. .. . |.|| | ||  |   | ..||.| ..  .    ....|  ||..| |.|   .|.|| .  || .| ..             | .   
adksGsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvv.vsRvnGaLAvsRalGDyeykeeeekkaeeqlvsaepe

YRNIQLNEQIEGLIVGNNMIWNMLSIDDLNSTFHNN
 . |. .|. . |..    || .|| ... .  ...
vtsierseeddflvlacDGiwDvlsdeevvelvrkr
subfamily_PPM1G_pd Subfamily PPM1G 738-821 2.1e-08 26.6 In-house 290-373 (473) alignment 
Range on Protein: 738-821
Range on HMM: 290-373/473.0
GEEGERLGASVMIIRVHEKRLEIASTGTMSAAIARNQK-LKMIINGRyEIDDDEYSRIREAHGFVDEENRINGVIGSSRQIGHFS
 |.||  |.  ... ..||.| .|  |   . ..|| | | . .. .  .|. | .||..| | |||. |.|| .  || .| ..
eepGedsGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHk.PeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDha
0049733 PP2C-like 704-894 2.2e-08 27.0 In-house 42-230 (235) alignment 
Range on Protein: 704-894
Range on HMM: 42-230/235.0
SYMSSSICRFMTSYLKENVSMDIRSILLRCHCEL----GE------EGERLGASVMIIRVHEKRLEIASTGTMSAAIARNQKLKMIINGRYEIDDDEYSR
 ..|. ..... ..|.|  ..|.. .| ..  ..     |      |  . |... .. .....| .|. |   | . |..||  .       ...|. |
evasellvetllelllelllldleealrkaflaaneallelalaspelagmgtTavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqr

IREAHGFVdeenRINGVIGSSRQIGHFSTFpvvlptHSYRNIQLNEQIeGLIVGNNMIWNMLSIDDLNSTFHNnRSPIVVAKKIQDQLQSYDYGGNSNIL
|..|.|.|    |..|..  .| .|..           .. ..|...   |..    .|..|| ... .....  ..  .|... ..  ..    |  ..
iitaggav....rvpgrlaltralGdlllk......pdvtvlelepgd.flllasDGlwdvlsdeeivdllrs.ldleeaaerlvelalarggrDNiTvv

V
|
v
LRR_4 Leucine Rich repeats (2 copies) 198-236 2.9e-08 23.1 Pfam-A 2-40 (44) alignment 
Range on Protein: 198-236
Range on HMM: 2-40/44.0
SLQVIDLSANQILSFPIQLTLLSHLRQLNLSSNYISSVP
.|.|.||| |.| . | .|  |. |..||||.| ||...
nLevLdLsnNnIkdlppelanLpnLktLnLsnNpisdls
LRR_8 Leucine rich repeat 464-520 3.1e-08 22.9 Pfam-A 3-59 (61) alignment 
Range on Protein: 464-520
Range on HMM: 3-59/61.0
LETLILYKNKLSSLPKHFFSILPRLRQLNISSNFIELLPYFDGSSFCRLQILRCANN
|..|.| .|.|...|...|. |..|..|..|.| .. ..    ... .|. |   .|
LkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkgLpsLreLnLsgN
LRR_4 Leucine Rich repeats (2 copies) 511-554 5.7e-08 22.2 Pfam-A 2-42 (44) alignment 
Range on Protein: 511-554
Range on HMM: 2-42/44.0
RLQILRCANNYLTenSVPV-IVNMKHLKIIDLSHNRLNSFddSAL
 |. |  .|| ..  ..|  . |.. || ..||.|.. ..  |||
nLevLdLsnNnIk..dlppelanLpnLktLnLsnNpisdl..saL
LRR_8 Leucine rich repeat 250-299 6.1e-08 22.0 Pfam-A 8-60 (61) alignment 
Range on Protein: 250-299
Range on HMM: 8-60/61.0
LSNNQLDTLPD-SISELQNLQSLDISFNQFSQIPPCLFHLT--LEMWRLAGNN
||||.|...|. | . |.||..||.| |  . |.|..|. .  |..  | ||.
LsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkgLpsLreLnLsgNr
LRR_8 Leucine rich repeat 395-447 1.4e-07 20.8 Pfam-A 2-56 (61) alignment 
Range on Protein: 395-447
Range on HMM: 2-56/61.0
NLQTLSLSFNHFRNLP-DWISDCPNLTFLRANNNSLVALPERIFYS-QSLRSIFA
||..| ||.|.....| .. ....||. |  ..|.|  .....| . .|||... 
nLkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkgLpsLreLnL
subfamily_PPM1G2_pd Subfamily PPM1G2 716-821 3.1e-07 22.6 In-house 83-191 (287) alignment 
Range on Protein: 716-821
Range on HMM: 83-191/287.0
SYLKENVSMDIRSILLRCHCELGEE----GERLGASVMIIRVHEKRLEIASTGTMSAAIARNQKLKMIINGRYEIDDDEYSRIREAHGFVdEENRINGVI
|. .....  ..  .|..  || ..     |  |.  ... ..|..| .| .|   | .. . ..| .       . .| .|| .| ||| | ||.||..
sfkegaleqilkdafletDeellkdeklkdesaGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfv.elnrvngnL

GSSRQIGHFS
  || .| |.
alsralgDfe
subfamily_PPM1K_pd Subfamily PPM1K 745-894 9.3e-07 21.2 In-house 101-255 (263) alignment 
Range on Protein: 745-894
Range on HMM: 101-255/263.0
GASVMIIRvHEKRLEIASTGTMSAAIARNQKLKMIINGRYEIDDDEYSRIREAHGFVD----EENRINGVIGSSRQIGHFSTFP-VVLPTHSYRNIQLNE
 |.| ..| . . | .||.|   | . || | | . .      ..|  ||..| |.|.    .. ..||..  .| .| .   .  |. |   ...... 
tatvsllr.dGtelvlaslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryGviatPetkslkvdh

QIEGLIV-GNNMIWNMLSIDDLNSTFHNNRSPIVVAKKIQDQLQSYDYGGNSNILV
. . ..|   . | ....  .|    .  . |   |. . .|   |    |. ..|
aadsflvlitdgisfvvnsqelcdlvrlchdpeeaahalteqalqygsednatavv
subfamily_ILKAP_pd Subfamily ILKAP 784-860 7e-06 18.4 In-house 159-235 (293) alignment 
Range on Protein: 784-860
Range on HMM: 159-235/293.0
YEIDDDEYSRIREAHGFVDeENRINGVIGSSRQIGH--FSTFPVVlPTHSYRNIQLNEQIEGLIVGNNMIWNMLSIDDL
  .. .|  ||. | |.|  ..|..||.. || ||   | .  |.  |   . ..|.|    ...  . .|. .| |. 
tpvkyeerkriqkaGgvvr.dgrvlGvlevsrsiGdgrfkrlGvi.stPdvkkceLtendlfvvlaCdGLwkvfsadev
LRR_1 Leucine Rich Repeat 244-265 7.5e-06 15.9 Pfam-A 1-22 (22) alignment 
Range on Protein: 244-265
Range on HMM: 1-22/22.0
RLQYLNLSNNQLDTLPDSISEL
.|..|.||.|.| .||.|.| |
nLeeLdLsgNnltslppslsnL
LRR_5 Leucine rich repeats (6 copies) 415-499 9.6e-06 11.8 Pfam-A 10-94 (129) alignment 
Range on Protein: 415-499
Range on HMM: 10-94/129.0
DCPNLTFLRANnNSLVALPERIFYSQ-SLRSIfAFINEIEHIPDFGEENC--LETLILyKNKLSSLPKHFFSILPRLRQLNISSNFIE
.| ||| .  . .|.  . |. |..  ||.||  . .... | ..  .||  |... . ...|.|.... ||    |...||.|.. .
ncknltsitip.ssvtsIgeyaFsncsslksi.tlpsslteigeyaFsncssltsiti.pssltsigenaFsncsslksinipssltt