Gene fem-2 in Caenorhabditis elegans

Synonym: CELE_T19C3.8, fem-2

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1E
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP104_AA protein Get Run
CeleP104_AA_152-426 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1E_pd Subfamily PPM1E 159-426 5.2e-103 336.8 In-house 2-264 (265) alignment 
Range on Protein: 159-426
Range on HMM: 2-264/265.0
SGIHVSGDQLKGQRHKQEDRFLAYPN-GQYMD-RGEDPISVLAVFDGHGGHECSQYAAGHLWEtwLEVRKSRDPSDSLeDQLRKSLELLDERMTVRSVKE
| ..|| ...|..|.|.|||..|... ..... ..|......||||||||.|...||| ||.|  |.||......|.. ..|.....|.|||.. ....|
seyevsiaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhe..llvrqeklkedpa.ealkeafkltDerflqkaere

CWKGGSTAVCCAIDMDQklMALAWLGDSPGYVMSNIEFRQLTRGHSPSDEREARRVEEAGGQLFVIgGELRVNGVLNLTRALGDVPGRPMISNEPETCQV
..|.|||||...|..||  ...||||||........|..||...|.|..|.|..|.|||||...|| |..||||||...||.|||  .|..|.|.....|
klksGstavvvliekdq..lyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvi.gawRvnGvLsvsRaiGDvklkpyvsgeadvaev

PIESSDYLVLLACDGISDVFNERDLYQLVEAFANDyPVEDYAELSRFICTKAIEAGSADNVSVVIGFLRP
....|.....|||||..||.||.....|||.|..| ..||..|........|.||||.||..||..|| |
eldgseeylilacDGlwDvvneeevvklveeflad.gaedlsevakllveaakeagssDnitvvvvfldp
PPM_PTC7 162-417 3.1e-64 209.9 In-house 2-259 (259) alignment 
Range on Protein: 162-417
Range on HMM: 2-259/259.0
HVSGDQLKGQRHKQEDRFLAYPNGQYMdRGEDPISVLAVFDGHGGHECSQYAAGHLWeTWLEVRKSRDPSDSLEDQLRKSLELLDERMTVRS----VkEC
...... .| |.. ||. .|..| . . .|.|.....||||||||.|...||. ||. ..|. ||| .... ||..|||| . || ... .|      |.
dggasafqgfrksmedahialanless.sgkdsvaffavfdghggreaakyarehle.eilkerksfeeleklekalrksflaldtdeelksseant.ep

WKGGSTAVCCAIDMDQklMALAWLGDSPGYVMSNIEFR-QLTRGHSPSDEREARRVEEAGGQLFVIgGELRVNGVLNLTRALGDVPGRP------MISNE
...|||||...|  ..  .  |..|||  ..... ... |||. |.||.|.|..|.|.|||..  . |. ||||||...||.||.   |      ..|.|
stsGstAvvalitgsk..lyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnv.gngrvngvlavsRafGdfelkpketeeqlvsae

PETCQVPIESSDYLVLLACDGISDVFNERDLYQLVEAFANDYpveDYAELSRFICTKAIEAGSADNV
|......|...|  ..||.||. ||...... .||  . ..    |  |... ....||. ||.||.
PdisstkideedefliLasdGlwdvvsdqeavdlvrselskk...dpmeaaeklvdeaiargsedni
PP2C Protein phosphatase 2C 162-417 3.8e-64 209.7 Pfam-A 2-255 (255) alignment 
Range on Protein: 162-417
Range on HMM: 2-255/255.0
HVSGDQLKGQRHKQEDRFLAYPNGQYMdRGEDPISVLAVFDGHGGHECSQYAAGHLWeTWLEVRKSRDPSDSLEDQLRKSLELlDERMTVRS--VK-ECW
.|....|.| |.. ||. .|..| . . .|.......||||||||.|...||. ||. ..|. .|| .... .|..|||| .  |......|   . |..
dvgaselqgarksmedahialknleks.sgkssvaffavfdghggreaakyarehle.eilkeqksflelekvekalrksfla.dtdeelksskanteps

KGGSTAVCCAIDMDQklMALAWLGDSPGYVMSNIEFR-QLTRGHSPSDEREARRVEEAGGQLFViggELRVNGVLNLTRALGDVPGRP----MISNEPET
| |||||.. |  ..  . .|..|||  ..... ... .||. |.||||.|..|.|||||..     . ||||.|...|||||.   |    ..|.||..
ksGstavvalirgkk..lyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn...ngrvngsLavsRalGdfelkpkeeqlvsaePdv

CQVPIESSDYLVLLACDGISDVFNERDLYQLVEAFANDYPveDYAELSRFICTKAIEAGSADNV
..|.....|  ..||.||. ||........||. . ..    .  |... ....||. ||.||.
tsvklteedefliLasdGlwdvlsdqeavdlvrselskkk..spmeaaeelvdeaiargsedni
PP2C Protein phosphatase 2C 162-417 3.8e-64 209.7 In-house 2-255 (255) alignment 
Range on Protein: 162-417
Range on HMM: 2-255/255.0
HVSGDQLKGQRHKQEDRFLAYPNGQYMdRGEDPISVLAVFDGHGGHECSQYAAGHLWeTWLEVRKSRDPSDSLEDQLRKSLELlDERMTVRS--VK-ECW
.|....|.| |.. ||. .|..| . . .|.......||||||||.|...||. ||. ..|. .|| .... .|..|||| .  |......|   . |..
dvgaselqgarksmedahialknleks.sgkssvaffavfdghggreaakyarehle.eilkeqksflelekvekalrksfla.dtdeelksskanteps

KGGSTAVCCAIDMDQklMALAWLGDSPGYVMSNIEFR-QLTRGHSPSDEREARRVEEAGGQLFViggELRVNGVLNLTRALGDVPGRP----MISNEPET
| |||||.. |  ..  . .|..|||  ..... ... .||. |.||||.|..|.|||||..     . ||||.|...|||||.   |    ..|.||..
ksGstavvalirgkk..lyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn...ngrvngsLavsRalGdfelkpkeeqlvsaePdv

CQVPIESSDYLVLLACDGISDVFNERDLYQLVEAFANDYPveDYAELSRFICTKAIEAGSADNV
..|.....|  ..||.||. ||........||. . ..    .  |... ....||. ||.||.
tsvklteedefliLasdGlwdvlsdqeavdlvrselskkk..spmeaaeelvdeaiargsedni
0034914 PP2C-like 153-426 9.6e-59 191.6 In-house 13-292 (295) alignment 
Range on Protein: 153-426
Range on HMM: 13-292/295.0
ILSEKWSGIHVSGDQLKGQRHKQEDRFLAYPNGQYMDRgedPISVLAVFDGHGGHECSQYAAGHLWETWLE-----VRKSRDPSDSLEDQLRKSLELLDE
 ||  .  ..|..   .|.|...||..|...|  ....   ......||||||||.....|. .|.|. ||     .  . ......|. |||..  .||
llsslllllrvgvasdqGrrksneDavlvvlnllslle...dlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaade

RMTVRSVK--ECWKGGSTAVCCAIdmDQKLMALAWLGDSPGYVMSNIEFRQLTRGHSPSDEREARRVEEAGGQLFVigGelRVNGVLNLTRALGDVPGR-
..   ...  |.. .|.|||.. |   .. . .|..|||  ....| |..|||. |.|..| | .|...|||  .   |  ||||||..||||||..   
ellelallrpelagsGtTavvali..rgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavsh..g..rvngvlavtRalGdfdlkl

--------PMISNEPETCQVPIE-SSDYLVLLACDGISDVFNERDLYQLVEAFANdyPVEDYAELSRFICTKAIEAGSADNVSVVIGFLRP
        |..|.||........ ..| ..|||.||..||... .....|  . .     |. |... ..  |...|| ||..||. .|..
llslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrslla..kgldleeaaeeLvdlAlargsrDNiTvvvvrlng
PP2Cc_SM00332 157-421 2.6e-54 177.5 In-house 6-273 (274) alignment 
Range on Protein: 157-421
Range on HMM: 6-273/274.0
KWSGIHVSGDQLKGQRHKQEDRFLAYPNGQymdrGEDPISVLAVFDGHGGHECSQYAAGHLWETWLEVRKSRDP--SDSLEDQLRKSLELLDERMTVRS-
...|.  . .. .|.|...||..  ... .     |.  .. .|||||||.|...... .|.|   |  |. .   .|. |. |.|... .||...    
snlglsygkssmqgwrksmeDahvvvvdlv....eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeq

--VKECWKGGSTAVCCAIDMDQklMALAWLGDSPGYVMSNIEFRQLTRGHSPSDEREARRVEEAGGqlFVIGGelRVNGVLNLTRALGDVPGR-------
   .| .. |||||.. .. ..  . .|..|||  ....| ...||.. |.|.||.| .|...|||  .|. |  ||||.|...||.||.          
skelenalsGstavvallkked..lyvanvGDSravlcrngkavqlsvdhkpedederkRikkagg..vvekg..rvngglavsrafGdhflkknkklke

PMISNEPETCQVPIESSDYLVLLACDGISDVFNERDLYQLVEAFANDYPVEDYAELSRFICTKAIEA-GSADNVSVVI
|.|..||.. .| . |.| ...||.||. ||... .....|... .    .|. | .  .. .||.. ||.||..||.
pyitaepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvv
0049733 PP2C-like 164-424 6.7e-48 156.0 In-house 6-233 (235) alignment 
Range on Protein: 164-424
Range on HMM: 6-233/235.0
SGDQLKGQ-RHKQEDRFLAypngqymdrgedPISVLAVFDGHGGHECSQYAAGHLWETWLEVRKSrDPSDSLEDQLRKSLELLDERMTVRSVK--ECWKG
.. . .|. |. .||..|.             ....||.||||||.....|...|.||.||  ..  .. .||. |||... ..|..  ....  |.. .
gaasdigrvrkvneDavlv............glllfavaDGhgghaagevasellvetllellle.lllldleealrkaflaaneallelalaspelagm

GSTAVCCAIDmdQKLMALAWLGDSPGYVMSNIEFRQLTRGHSPSDEREARRVEEAGGQLfviggelRVNGVLNLTRALGDVPGRpmisnePETCQVPIES
|.|||.. .|  .. . .|..|||  |.... ...|||. |||..| | .|...||| .       ||.|.| ||||||| .        |.......|.
gtTavvalld..ggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav.......rvpgrlaltralGdlllk......pdvtvlelep

SDyLVLLACDGISDVFNERDLYQLVEAfandypvEDYAELSRFICTKAIEAGSADNVSVVIGFL
 | ..|||.||..||... ....|.          |. |. ....  |...|. ||..||. .|
gd.flllasDGlwdvlsdeeivdllrs.......ldleeaaerlvelalarggrDNiTvvvvrl
subfamily_PPM1A_pd Subfamily PPM1A 161-421 3.6e-46 150.8 In-house 12-277 (282) alignment 
Range on Protein: 161-421
Range on HMM: 12-277/282.0
IHVSGDQLKGQRHKQEDRFLAYPNgqyMDrGEDPISVLAVFDGHGGHECSQYAAGHLWETWLE------VRKSRDPSDSLEDQLRKSLELLDERMTVRSV
.... .. .| | . ||.. .  .   .  .    |  ||||||.|.|...|.. || |. ||        ......|.....||...  |||..   | 
lrygvssmqgwrvemEDahtvvas...lg.alkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairelst

KE--CWKGGSTAVCCAIDmdQKLMALAWLGDSPGYVMSNIEFRQLTRGHSPSDEREARRVEEAGGQLFviggELRVNGVLNLTRALGDVPGRP-------
.   . | |||||.. .   .| . .| |||| . ...| .   ||. | ||...| .|.|.|||..       |||| | ..|||||   .        
dlktadksGsTavtvlvs..ekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvv....vsRvnGaLAvsRalGDyeykeeeekkae

--MISNEPETCQVPIESSDYLVLLACDGISDVFNERDLYQLVEAFANDYpvEDYAELSRFICTKAIEAGSADNVSVVI
  ..|.|||.  . ....|  ..|||||| || .. .. .||.   .    ..  |... .  ||.|.|| ||.||..
eqlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrleva..deleevakalvdkalekgsrDNlsvlv
subfamily_PPM1G2_pd Subfamily PPM1G2 163-421 2.8e-36 117.9 In-house 21-283 (287) alignment 
Range on Protein: 163-421
Range on HMM: 21-283/287.0
VSGDQLKGQRHKQEDRFLAYPNgqYMDR-GEDPISVLAVFDGHGGHECSQYAAGHLWeTWLEVRKSRDpSDSLEDQLRKSLELLDERMTVRS-VKEcWKG
|.   ..| | ..||  .  ..   ...  .. ....||||||||.....||. .|   ... .|| . ...||  |....  .|| ..  . .|.  . 
vgssamqGyrlnmeDahilene..lleksddkslalfavfDGhGGakvakyagkkli.kkiakkksfk.egaleqilkdafletDeellkdeklkd.esa

GSTAVCCAIDMDQklMALAWLGDSPGYVMSNIEFRQLTRGHSPSDEREARRVEEAGGqlFVIGGelRVNGVLNLTRALGDV---------PGRPMISNEP
|||||   |  ..  .  |  |||   . |... ..|.. | |..| |..|...|||  ||  .  ||||.| | |||||          |   ..  .|
Gstavvvlikeek..lyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagG..fveln..rvngnLalsralgDfefkknvkkkpeeqivtavP

ETCQVPIESSDYLVLLACDGISDVFNERDLYQLVEAFA-NDYPVEDY-AELSRFICTKAIEAG--SADNVSVVI
.     ....|  ..|||||| ||...... .||     ..  ...   ||    .... ...   .||..|||
DvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvvi
subfamily_PPM1K_pd Subfamily PPM1K 164-423 3e-31 101.5 In-house 7-257 (263) alignment 
Range on Protein: 164-423
Range on HMM: 7-257/263.0
SGDQLKGQRHKQEDRFlaypngqYMDRGEDPISVLAVFDGHGGHECSQYAAGHLWETwleVRKSRDPSDSLEDQLRKSLELLDERMTVR-----SVKECW
  | | |.|.. |||.        . . .. .  .||||||.|  . ...  .| ..   ...  .  . ||  |....| ||....       . .|  
GkdsliGkraenedri.......klkeldpellyvavfdGhaGsaaadfvhdkleki...lkrllekekdleivlknafeeldkklkrylefsvaeaell

KGGSTAVCCAIdMDQKLMALAWLGDSPGYVMSNIEFRQLTRGHSPSDEREARRVEEAGGQLFV-IGGELRVNGVLNLTRALGDVPGRPM-ISNEPETCQV
. |.||  . .  | . ..|| ||||   .  | . ..||| |.|. | | .|. .|||..     |...|||.| .||.|||.  ..  .  .||| ..
ssGttatvsll.rdGtelvlaslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryGviatPetksl

PI-ESSDYLVLLACDGISDVFNERDLYQLVEAFANdyPvedyAELSRFICTKAIEAGSADNVSVVIGF
 .  ..| ...|  ||||.| |...| .||.   .  |     | .......|.. || ||...|.  
kvdhaadsflvlitdgisfvvnsqelcdlvrlchd..p....eeaahalteqalqygsednatavvvp
PPM_PTC7_SpoIIE 163-409 1.4e-30 99.8 In-house 3-222 (230) alignment 
Range on Protein: 163-409
Range on HMM: 3-222/230.0
VSGDQLKGQRHKQEDRFLAYPNGQYMdRGEDPISVLAVFDGHGGHEcsQYAAGHLWeTWLEVRKsRDPSDSLEDQLRKSLELLDERMTVRsvkeCWKGGS
... . .| |.. ||.  ...| . . .|..   |....|||||..  ..|.|.|. |.|. .. .  .. .|. ||.. ..|. ... .    ....|.
ggasaaqgarksmedahispanseks.sggrlalvvgdvdGhGgra..alamgllr.talrela.faglekpeeilrrlnlalaadlede....psssga

TAVCCAIDMDQKLMALAWLGDSPGYVMSNiEFRqltrghspsderEARRVeEAGGQLFvIGG-ELRVNGVLNLTRALGDVPGRP---MISNEPETCQVPI
|||.. || ..  . .|..|||| ..... . .            |..|. .||| .  .|  . ||.|||....| ||.   .   ....||.| .   
TavvalidpstgklyvanaGdsppllvrd.dgg............ereri.vagglps.lGilpgrvfgvlavslapGdllllytDGvveaepdtsdgel

ESSDYLVLLACDGISDVFNERDLYQLVEAFANDYpvedyaeLSRFICTKAI
.. | .. ||.||. || .  .| .||    ...       ... . . .|
fgkdeflilasdglwdvlspqelvdlvrdelekp.......aaeglleDDi
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 162-421 2.3e-30 98.7 In-house 7-250 (255) alignment 
Range on Protein: 162-421
Range on HMM: 7-250/255.0
HVSGDQLKGQRHKQEDRFLAYpnGQYMDRGEDPIsvLAVFDGHGGHECSQYAAGHLWETWLEVR---KSrDPSDSledqLRKSLELLDERMTVRSvKECw
.|.  .. |.|   ||.. .|  |.. |. .. .  .|.||||||.. ...|. .|     |.    .. .| .|    |.|. . .. ... |. | . 
kvgfsdmiGrrptmedelviy..Gsfrdksdedy..yalfdGhgGraaakfaseelykilaelldlnna.nPvks....lkkaykeistqiserp.kfi.

kgGSTAVCCAIDMDqkLMALAWLGDSPGYVM-SNIEFRQLTRGHSPSDEREARRVEEAGGQLFVIGGELRVNGVLNLTRALGDVPGRPMISNEPETC-QV
  |.||.   |  |   . .| .|||   .   .   ..|.  | ||.|.| .|..|.||..       |||| | ..|||||.   | . ..|.   ..
..Gttaasvliied..kvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsflePfvvpdPdlsqsl

PIESSDYLVLLACDGISDVFNERDLYQLVeafANdypVEDYAELSRFICTKAIEAGSADNVSVVI
 |  .|  ..|||||| |.  ...  ..|   |.   ..|  . .  .  .| . || ||.||..
eiskkdkflilacdGiwdlisdeeaveiv...ag...isdpekaaeklrdlayssGstdnisviv
subfamily_ILKAP_pd Subfamily ILKAP 169-421 7.8e-28 90.5 In-house 13-289 (293) alignment 
Range on Protein: 169-421
Range on HMM: 13-289/293.0
KGQRHKQEDRFLAYPNGQYM-DRGED---PISVLAVFDGHGGHECSQYAAGHLWETWLEVRKSRDPSD---SLEDQLRKSLELLDERMT--VRSVKECWK
||.|.. .|  .   . .    . ..    .|  ||||||.|.  |..|| .| .. ||   . | |    ..   | .| .  || .    .. |  ||
kGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefLklaskakPvWk

GGSTAVCCAIdMDQKLMaLAWLGDSPGYVMSN------IEFRQLTRGHSPSDEREARRVEEAGGQLfvIggELRVNGVLNLTRALGDVPGRP-MISNEPE
 ||||... . .|. |   | ||||   .. .      | . .||. |.| .. | .|.. |||..     . ||.|||. .|..||   .   ..  |.
dGstatvvlv.ldnvly.vanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvv..r..dgrvlGvlevsrsiGdgrfkrlGvistPd

TCQVPIESSDYLVLLACDGISDVFNERDLYQLVEAFANDY---------PVEDYAEL-----SRFICTKAIEAGSADNVSVVI
. .. ..  |  |.|||||. .||.  .  . . .  .|          .... .|      .  . ..|.. ||.|||.|..
vkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrkikeeekkskeevrfevacnrlaseavkrgssdnvtvll
subfamily_PPM1L_pd Subfamily PPM1L 167-421 6.5e-22 71.0 In-house 11-263 (269) alignment 
Range on Protein: 167-421
Range on HMM: 11-263/269.0
QLKGQRHKQEDRFLAYPNGQymdrGEDPISVLAVFDGHGGHECSQYAAGHLWETWL----EVRKSRDPSD--SLEDQLRKSLELLDERMTVRSVKECWKG
 ..|.| . ||||    . .     .  .|..||||||||   ...|   | .. .    |. .... .   . .  | . .  .||..  .  ..    
svlGrrprmedrfeieedik....nktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakraedia

GSTAVCcAIDMDQKLMaLAWLGDSPGyVMSNIE--FRQLTRGHSPSDEREARRVEEAGGQLfVIGGELRVNGVLNLTRALGDVPG--RPMISNEPETCQV
|.||.  |.  ...|. .| .||| | |. . .     |.  | | . .| .|...||| .  . |  ||.|||  .||||| |   . ..  .|.    
Gttali.alvqesdli.vanvGdsrG.vlydkrGkaiplsfdhkpqqvkerkrikkaGGfi.afrGvwrvaGvlatsralGdyplkdknlviadpdiltf

PIESSD-YLVLLACDGISDVFNERDLYQLVEAFANDyPveDYAelSRFICTKAIEAGSADNVSVVI
 ..  .  ...||.||. | | . .  . .    .. |  |.   .. .  ..   || ||..|..
dlddhkpeflilasdGlwdtfsneeavrfikerlke.p..dfG..akslvlesfkrGsvdnitvlv
subfamily_PPM1D_pd Subfamily PPM1D 162-425 1.2e-19 63.6 In-house 3-308 (309) alignment 
Range on Protein: 162-425
Range on HMM: 3-308/309.0
HVSGDQLKGQRHKQEDRFLAYPNGQYMDRgEDPISVLAVFDGHGGHECSQYAAGHLWETWLEVRK-SRDPSDSLEDQLRKSLELLDERMTvrSVKECW--
.|.    .|.|.  ||..  . . .   . |   ...||||||||.| ...|  |||..  . .|   ...... . .|..   . | |    ..| |  
svtseadqGgrkymeDvvaivleeeesae.elevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamk..kkleeWpk

---KGGSTA--VCCAIDMDQKLMALAWLGDSPGYVMS------NIEFRQLTRGHSPSDEREARRVEEAGGQLFVIGGELRV---------NGV-------
   .  |||   .  . . .. . .|  |||   . .      ... ..||. | |.. .| .|.||.||.. .  |  ||         ||        
tksgllstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngptvideiP

-LNLTRALGDV------PGRPMISNEPETCQVPIESSDY-LVLLACDGISDVFNERDLYQLVEAFANDYPV--EDYAELSRFICTKAIEAGS-----ADN
 |...|.|||.       |. ..| ||..... .. ..   ..|| ||. .| . .|  ..||   .   .  |   . .. . ..|..  .     |||
FLavaRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklraDn

VSVVIGFLR
|||.. .|.
vsvivvile
subfamily_PPM1G_pd Subfamily PPM1G 256-387 1.7e-18 59.9 In-house 292-427 (473) alignment 
Range on Protein: 256-387
Range on HMM: 292-427/473.0
ECWKGGSTAVCCAIDmdQKLMALAWLGDSPGYVMSNIEFRQLTRGHSPSDEREARRVEEAGGQlfvIGGELRVNGVLNLTRALGDVP---------GRPM
.  . |.||| . .   .| .  |  |||   . .| .  .|   | | || |..|.|.|||.   .  ..|||| ||| |||||              |
pGedsGttAvvaLlk..ekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGk...vdedgRvnGGLnlsRAlGDhaYkkneeLplkeqm

ISNEPETCQVPIESSDYLVLLACDGISDVFNERDLYQLVEA
||  |.  .  . . |  . |||||| .| . ..  . |.|
isAlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvra
subfamily_KAPP-like_pd Subfamily KAPP-like 177-421 2.8e-18 58.9 In-house 14-263 (266) alignment 
Range on Protein: 177-421
Range on HMM: 14-263/266.0
DRFLA-YPNGQYMD-RGEDPISVLAVFDGHGGHECSQYAAGHLWETWLEVRKSRDPSDSLEDQLRKSLELLDERMTVRS-VKECWKGGSTAVCCAI--DM
| .|| || ..  .      |...|||||| |. ... |   . .   .  || .  |  ...  .|  |..    | . .|.    |.||  . .  | 
dvslaiypllkekklsncsnialfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafkevdaklkdfeyeGatatlalvwsdG

DQKLMALAWLGDSPGYVMSNIEFRQLTRGHSPSDEREARRVEEAGgqLFVIGGELRVNGVLnLTRALGDVPGR----PMISNEPETCQVPIESSDYLVLL
.|...  | .|||  ..    |  .|.  |   |..| .|. . |  . .  .. |.||.. ..|||||   .     .||.   . .. .   |  ...
qqrylqvanvGdssaflsrGneslelskdhkakdpeekqrikddG..itlsdnqtrinGla.vsralGdhfikelniGlisepyvsnrilltpfdkfliv

ACDGISDVFNERDLYQLVEAFANDYPVEDyaELSRFICTKAIEAG-SADNVSVVI
| ||. || . .|  . |... ..   ||  ...  .   ||..  . |||||..
asdGlwdvisGkdaiekvkslydqqated..kmasslletaiqsikakdnvsviv
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 190-341 2.8e-17 56.2 In-house 15-183 (292) alignment 
Range on Protein: 190-341
Range on HMM: 15-183/292.0
RGEDPISV-LAVFDGHG--GHECSQYAAGHLWETWLEvrkSRDPSDSLEDQLRKSLELLDERMTVRSVkECWKGGSTAVCCAIDMDQKLMALAWLGDSPG
.| ....   ||.||||  |.. .|.|. .|    ||   .  .   | . | . .  .  ..    . .  . ..||| ||.  |.. . || .|||  
egsealtflaavldGhGvnGdkvaqlaedtlevelle...ltrqlqelsealllrildiaakldklti.daresattavvcarvrddralilanvGdsra

YVMS-----NIEFRQLTRGHSPSDEREARRVEEAGGQLF-------VIGGELRV------NGVLNLTRALGDV
 .       . | . |.| | |.|  | .|.  |||..           |  ||      .| | |.|||||.
llgrclggsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdf
PP2C_SIG_SM00331 196-423 1.7e-16 53.4 In-house 31-216 (217) alignment 
Range on Protein: 196-423
Range on HMM: 31-216/217.0
SVLAVFDGHGGHECSQYAAGHLWETWLEVRKSRdpsDSLEDQLRKSLELLDERmtvrsvKECWKGGSTAVCCAIDMDQKLMALAWLGDSPGYVMS-NIEF
 .|.|.||.|.. ... |.. | .   |  ...   ..|.. |..  ....|.      ||.  .. |.... .|. .. . .| .|||. |..  . ..
lllvvaDgmGkGlaAaaassqlrtalrellseg...eelsqalkrlnraiyee......keekgmfaTlllalydfssgklsyanaGdsrpyllrdgklv

RQLTRghspsderearrveeaggqlfviggelrvngvlNLTRALGDVPGRPmisnePETCQVPIESsDYLVLLACDGISDV-----FNERDLYQLVEAFA
 .|.                                  .....||  | ..     ... .. .|  . |.||. ||. ..     |.| .| ...|...
eilkd.................................vegaplGlepevs.....vdirelelek.gdllllytDGltearsekgfaeerleeiledlv

nDYPVEDYAE-LSRFICTKAIEAGSADNVSVVIGF
 | .... |.   . ....| ...  |...||. .
.dseaqelaqkiveellelakgsngeDdiTvvvvk
subfamily_PP2D1_pd Subfamily PP2D1 293-389 5.7e-14 44.7 In-house 207-306 (492) alignment 
Range on Protein: 293-389
Range on HMM: 207-306/492.0
EFRQLTRGHSPSDEREARRVEEAGGQLFVIGGELRVNGVLNLTRALGDV---PGRPMISNEPETCQVPIESSDYLVLLACDGISDVFNERDLYQLVEAFA
.  .||| | | ...| .||| ||. .   .   .|||.|. || ||       .  .  ||.|  |...  . ...||  |. .|..| .  .||. . 
kaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdpkLkksvipePkttsvkldeaaqflvlAsnGlWevlseeevlsLvkqtl
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 177-421 1.9e-13 42.9 In-house 13-273 (276) alignment 
Range on Protein: 177-421
Range on HMM: 13-273/276.0
DRFLA-YPNGQYMD-RGEDPISVLAVFDGHGGHECSQYAAGHLWETWLEVRKS--------RDPSDSLEDQLRKSLELLDErMTvRSVKECWKGGSTAVC
| .|| || ..  |      |...|||||| |. ... |   . .  . . ||         |  |.  || .  |.|..| .    .|.    |.||  
dvslaiyplldekdlsncsnialfavfdGhaGkGaadaakklfpkelekllksgnysltkqddGGdniydqskllldlfke.vd.aklkdfeyeGatatl

CAIDM--------DQKLMALAWLGDSPGYVMSNIEFRQLTRGHSPSDEREARRVEEAGgqLFVIGGELRVNGVLnLTRALGDVPGR----PMISNEPETC
. .          .|. .  | .|||  ..    |  .|.  |  .|  | .|. . |  . .  .. |.||.. ..|||||   .     .||.   . 
alvwsdGeeqqqqqqrylqvanvGdssaflsrGneslelskdhkatdpeekqrikddG..itlsdnqtrinGla.vsralGdhfikelniGlisepyvsn

QVPIESSDYLVLLACDGISDVFNERDLYQLVEAFANDYPVEDyaELSRFICTKAIEAG-SADNVSVVI
.. .   |  ...| ||. || . .|  . |... ..   ||  ...  .   ||..  . |||||..
rilltpfdkflivasdGlwdvisGkdaiekvkslydqqated..kmasslletaiqsikakdnvsviv
PPM_PTC7_motif 366-417 1.7e-12 40.6 In-house 1-51 (51) alignment 
Range on Protein: 366-417
Range on HMM: 1-51/51.0
LLACDGISDVFNERDLYQLVEAFAN-DYPveDYAELSRFICTKAIEAGSADNV
.||.||. ||........||  . . ...  .. |... ....|.. ||.||.
iLAsDGLWDvlsdqeavdlvrdqlskkgl..spqeaAeklvdealargseDni
Subfamily Dicty-PPM1L-like 283-424 2.1e-12 39.5 In-house 162-303 (305) alignment 
Range on Protein: 283-424
Range on HMM: 162-303/305.0
DSPGYVMSNIEFRQltrgHSPSDeREARRVEEAGGQLFVIgGELRVNGVLNLTRALGDVPGRPMISNEPETC-QVPIESSDYLVLLACDGISDVFNERDL
||||..  |  . |        |  .  |.| ... |.   |||.||..|.  |  ||   . ..  ...    |  ...|  ..|| ||. .|..  |.
dspgwmkfnhlynq....nnfld.eiririeslqaalyny.gellvnrllkksrskGdknlkelviPnndspllvvakanDqflvlatdGlwevlsyqdv

YQLVEAFANDYPVE-----DYAELSRFICTKAIEAGSADNVSVVIGFL
 . |..  .|   .     |. |.|| |  .|.. || ||. .|| .|
veevkellrdkssqkkiewdfneisrviveeavkrgsgDnitlviikl
subfamily_PPM1G_pd Subfamily PPM1G 168-219 2.9e-07 22.8 In-house 26-71 (473) alignment 
Range on Protein: 168-219
Range on HMM: 26-71/473.0
LKGQRHKQEDRFLAYPNgqymdrGEDPISVLAVFDGHGGHECSQYAAGHLWE
 .| |..|||   . ..       .. .|..||.|||||.| ..| | .| .
mqGwrvsqEDahncitd......ldedtslfavyDGHGGkevakyvakklpd
PP2C_2 Protein phosphatase 2C 193-390 6.8e-07 21.8 Pfam-A 22-196 (212) alignment 
Range on Protein: 193-390
Range on HMM: 22-196/212.0
DPISVLAVFDGHGGHECSQYAAGHLWETWLEVRKSRDPSDSLEDqLRKSLELLDERMT--------VRSVKECWKGGSTAVCCAIdMDQKLMALAWLGDS
.  ..||| ||.| .. |. .|  . |. .|  ..   ..|...  .. |. . ...           . .|  |  .|....|. .. . ......||.
sdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqe.eeallrqieneilasvklkqeaeaqqeelkdyatTlllav.itpgeivffqiGDg

PGYV-MSNIEFRQLTRGHSPSDEREARRVEEAG--GQLfviggelrvngvlnltralgdvpgrpmisnepETCQVPIESSDYLvLLACDGISDVFN-ERD
  .|  .. |...|.  .|   ..| ...  .   ..|                                .. ... |. | | ||  ||.|| .. |..
aivvrdrdgevqllgepdsgeyanettfltsedaeeel................................rirrlklepgdal.llmTDGvsdslrkeep

LYQLVEAFAN
...|.. . .
frellaelle
PP2C_2 Protein phosphatase 2C 193-390 6.8e-07 21.8 In-house 22-196 (212) alignment 
Range on Protein: 193-390
Range on HMM: 22-196/212.0
DPISVLAVFDGHGGHECSQYAAGHLWETWLEVRKSRDPSDSLEDqLRKSLELLDERMT--------VRSVKECWKGGSTAVCCAIdMDQKLMALAWLGDS
.  ..||| ||.| .. |. .|  . |. .|  ..   ..|...  .. |. . ...           . .|  |  .|....|. .. . ......||.
sdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqe.eeallrqieneilasvklkqeaeaqqeelkdyatTlllav.itpgeivffqiGDg

PGYV-MSNIEFRQLTRGHSPSDEREARRVEEAG--GQLfviggelrvngvlnltralgdvpgrpmisnepETCQVPIESSDYLvLLACDGISDVFN-ERD
  .|  .. |...|.  .|   ..| ...  .   ..|                                .. ... |. | | ||  ||.|| .. |..
aivvrdrdgevqllgepdsgeyanettfltsedaeeel................................rirrlklepgdal.llmTDGvsdslrkeep

LYQLVEAFAN
...|.. . .
frellaelle
subfamily_PHLPP_pd Subfamily PHLPP 276-421 4.5e-06 18.7 In-house 107-242 (246) alignment 
Range on Protein: 276-421
Range on HMM: 107-242/246.0
MALAWLGDSPGYVMSNIEFRQLTRGHSPSDErEARRVEEAGGqlfVIGGELRVNGVLNLTRALGDVPGRPMISNEPETCQVPIESSDYLVLLACDGIsdv
. .|  |    ... | .  .|.. .. ... |..|. || .   .|  . ..|||.. || || .   |..  .|.  .|.... | |...  . .   
LevAsvGtlqavliRngkklrlsksyviekd.elkrikeaka...iitednkingviestrllGytflfPvvlPkphvrevlLteqdellivGnkal...

FNERDLYQLVEAFANdypVEDYAELSRFICTKAIEAGSADNVSVVI
..  .. ..|||. .   .||     . ... |   | ||.|||..
Wevlsideaveavrk...eedplvaAkklvdlaqsygaadsvsvlv