Gene gsp-2 in Caenorhabditis elegans

Synonym: CELE_F56C9.1, gsp-2

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP1C
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP106_AA protein Get Run
CeleP106_AA_3-302 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP1C_pd Subfamily PPP1C 21-300 3e-165 541.3 In-house 2-281 (282) alignment 
Range on Protein: 21-300
Range on HMM: 2-281/282.0
SKPGKNVQLTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLL
||.||.|.|.|.||. |..|.|||.||||||||||||.||.||.||||.|||||||..|.|||||||||||||||||||||||.||||||||||||.|||
skkgkevklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfll

RGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVTGWGENDR
|||||.|||||||||||||||||.|||||||||.|||||.||..||||.|.||||||.|.|.||||.|.||..||..|||||||||||||.|.||.||||
rGnhesasinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendr

GVSFTFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILKPADK
|||||||..||.|||.|.|||||.||||||||||||||||||||.||||||||||||||....|||.|..||||||||.|
GvsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpakk
subfamily_PPZ_pd Subfamily PPZ 7-300 2.7e-141 463.4 In-house 2-296 (300) alignment 
Range on Protein: 7-300
Range on HMM: 2-296/300.0
NLDNIISRLLEVR-GSKPGKNVQLTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICL
..|.|| .||.    .|  ||| | .|||  .|.|.||.||.|| ||||  ..|| ||||||| ||||||   |||| .||||||||||||||||||| |
dideiiqklldagyaakrtknvclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletill

LLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLW
||.||||||||||||||||||| . |.|||||||||| |||.|||| | || ||.|||.  |||| |||||| |.||..||...||||||| ||. ||||
llcykikypenffllrgnhecanvtrvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllw

SDPDKDVTGWGENDRGVSFTFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILKPADK
|||      | .|.||||. .    . ||| |  .||.|||| |||||||||  | |||.|||||||||||| |..|.| | |.|||..| | | 
sdptdssnewednergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldplds
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 8-301 1.3e-138 454.1 In-house 3-297 (298) alignment 
Range on Protein: 8-301
Range on HMM: 3-297/298.0
LDNIISRLLEVRGSKPGKNVQLTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLL
 |......|.|  |.     ...|.... |......|| .|. |.|..||.|.|||.|||| ||||||. .||||..||||||||||||.|.||.|.|||
vdellievlsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlll

AYKIKYPENFFLLRGNHECASINRIYGFYDECKRRY-NIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWS
|||.|||.|||||||||||..|||.||||.|||||| ...|...| | || ||..|.| ..|.| |||||. |.|..|.|.. ||.| ... |  ||||.
aykvkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwa

DPDKDVTGWGENDRGVSFTFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILKPADKK
||.. |.|| || ||||..|| .||...|.| |.||..|||||| |||||||...|||.||||.|||.|||. ..|.||| |..||..|||..|.
dpenavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpekke
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 7-301 4.2e-131 429.6 In-house 2-297 (299) alignment 
Range on Protein: 7-301
Range on HMM: 2-297/299.0
NLDNIISRLLEVRGSKPGKNVQLTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLL
..|...|.||.|  |.      . | |.. ||. ....|.||. |||.|||...|||.|||| ||||.|.  ||||..|.||||||||||.| ||.|.||
dvdellskllnvgmsekrltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitll

LAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYN-IKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLW
|..||||||.||.||||||| .|||.||||.||..||.  .||  | |.|. .|.. .|  .|.| |||||| ||...|.| . || | |.  |  ||||
lcfkikyperffmlrgnhecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllw

SDPDKDVTGWGENDRGVSFTFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILKPADKK
.|||. | .|  | ||||. ||..|||. ... |.||..||||||.|||||||...|||.|||| |||.|||. ..| ||| |.|.|..|||..|.
adpdqsvkdwlanvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpks
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 30-298 2.3e-122 400.5 In-house 7-275 (280) alignment 
Range on Protein: 30-298
Range on HMM: 7-275/280.0
TESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASI
 | .|... .| ..|.. |  ..|..||...|||.|||| ||||||.  .|||..||||||||||||.| || |.||||||..||.||..||||||..||
keadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisi

NRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVTGWGENDRGVSFTFGPE
|| |||.||.||||. .|.. | . .. ||..|..  .|.| |||||..|.|........|| | .|. |  ||||.||...||||.|| ||||  || .
nrkygfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifgan

VVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILKPA
|| .. .| |.|||.| ||||.|||||||...|||.||||.|.|||||. ... ||| |. ||..||||
vvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpa
0045823 Metallo-dependent phosphatases 16-302 2e-120 395.5 In-house 30-328 (473) alignment 
Range on Protein: 16-302
Range on HMM: 30-328/473.0
LEVRGSKPGKNVQLTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPE
|..  .   |. .|.|.... |... .||. ..| ||||.... ..||.|||..|||||.|  ||||| ...||||.|||| .|||...||||.|||||.
ldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkikypg

NFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPdKDVTG-
|.||||||||.. .| .|||.||. ..|...|.. | .....||.||.|..||...||||||||....|||.| || ..|| |||.|||||||  .. | 
nvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdP.weddgd

-------WGENDRGVSFTFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQ------LVTLFSAPNYCGEFDNAGSMMTVDETLmCSFQILKPADKK
       .| . ||....|||..| .||.|..||||.|.|..|..|||.. ...      ..|.||||||||...| ......||.| .||....|.. .
gllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsphp

K
.
l
0049330 Metallo-dependent phosphatases 4-301 4.6e-118 386.7 In-house 5-302 (309) alignment 
Range on Protein: 4-301
Range on HMM: 5-302/309.0
EKLNLDNIISRLLEVRGSKPGKNVQLTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETI
..| |...| .||..  ... | ..|.|.|.. |..| .||..|.|.||||.... ..||.|||..|||||.|  ||||| ...||||.|||| .|||..
dpllllelilslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevl

CLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDL
.||||.|..||.|.||||||||.. .|..|||.||..|.|...||. |.|....||.||.|..||.|.||||||||....|||...||...|. ||||||
llllalkllypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdl

LWSDPDKDVTGWGENDRGVSFTFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILKPADKK
|||||. .. |...|.||....||. .| .||.|..||||.|.|..|..||..|....|.|.||||||||...|.|.....||.|..||....|.. .
lwsdplpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpll
PP2Ac_SM00156 30-298 1.5e-117 384.5 In-house 2-270 (271) alignment 
Range on Protein: 30-298
Range on HMM: 2-270/271.0
TESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASI
...|.. |.....||. ... |.|..||. ..||.|||..|||||.| .|.|||..|.|||||||||.||.|.|.||.|.||.|||...|||||||. |.
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

NRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVTGWGENDRGVSFTFGPE
|.||||..|.||.|. .... |...|..||.||..|.||.| ||||||.|.|...||.. |. . |..|||.|||||||.... |.  . ||.|..||..
nkiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFged

VVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILKPA
.| .||.|..|.||.|||.||..||||||...|||.|||||||.||.|......|...|..|.. ||..
avkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq
PPP_1 30-283 4.7e-116 379.7 In-house 2-263 (264) alignment 
Range on Protein: 30-283
Range on HMM: 2-263/264.0
TESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASI
.|.|.. |..|..|.. ....|||.......|||.|||..|||.||..||..||.|||||||||||||.|.|...||||.|.|||...||||||||....
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

NRIYGFYDECK-RRYNIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLL-------WSDPDKDVTGWGENDRG
...|||..|.. ..|. ...||.||.|..||.||.|||||...||||||.|....|||...| |.||..| |||||       .||.... ... ...||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

VSFTFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMT
....||..|..|||.|..|.||.|||.|.|.||||..||..||.|||.||. |..|.|....
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
PPP_3 29-296 1.1e-115 378.3 In-house 2-270 (271) alignment 
Range on Protein: 29-296
Range on HMM: 2-270/271.0
LTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECAS
|.|.|.| |..| .||. ....|.|..||...|||.|||..|||.||..||..||..||||||||||||.|||...||||.|||||....|||||||...
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

INRIYGFYDECK-RRYNIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVTGWGENDRGVSFTFG
||..|||..|.. .... |..|.....|..||.||.||||....||||||...|..||... |...||..|.|.|||.|..... .|.....||....||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

PEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILK
|.|...||.|..|.||.|||...|.|||.......||.|||||||....|||......|.|...|..|.
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 29-297 2.5e-112 368.0 In-house 8-282 (284) alignment 
Range on Protein: 29-297
Range on HMM: 8-282/284.0
LTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFP------PESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRG
|.| |.  || ..||.|  ... ||.|||.||.||.|||. ||| |..  |.|       |..|||||||||||  |.| | ||.|||...|.. |||||
lkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrg

NHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVTGWGENDRGV
|||   .|. |||| |||.||  .|...|  .||..|..|....||.| |||.| || ...|. .. ||.|.|| |...|| |.||...|.|. | .|| 
nhesrpvnmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesprga

SFTFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILKP
  .||.. | .||.|..|||. |||||| ||||||| |.|||.|||| |||..||......||| |..||..|||
gkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkp
0053225 Metallo-dependent phosphatases 10-297 9.3e-108 352.9 In-house 3-290 (293) alignment 
Range on Protein: 10-297
Range on HMM: 3-290/293.0
NIISRLLEVRGSKPGKNVQLTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAY
..| .||..  .   ....|.|.|.. |... .||....|.||||.... ..||.||...|||.|.|. |||||....||||.|||| .|||...||||.
slilllldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllal

KIKYPENFFLLRGNHECASINRIYGFYDECKRRY-NIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDP
|..||.|..|||||||.. .| .|||.||..|.| . .||. ..|....||.||.|..||...|||||||| ...|||.|.||...|. |||.|||||||
kllypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdp

DkDVTGWGENDRGVSFTFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILKP
| ...||. . ||....||. .| .||.|..||||.|.|||| |||... ...|||.||||||.|...|.|.....|| |...|....|
d.lwsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfap
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 33-300 7e-107 350.1 In-house 7-276 (284) alignment 
Range on Protein: 33-300
Range on HMM: 7-276/284.0
EIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRI
... |  .. .||  ||.|.| ..|..||||.|||. ||||||.  |||  .|||||||||||||. |||| ||.|||. .|. ||.|||||||. ||.|
dvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinki

YGFYDECKRRYNI-KLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQG-LLCDLLWSDPDKDVTGWGENDRGVSFTFGPEV
||||.||.||||   ....|   |  .|..|.. ..|.| |||.|  || . |.| | || | |.   |  |.||||| .   ||  | ||||. || . 
ygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsda

VAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILKPADK
. |.| . ..||. ||||||.|||||||.|.|||.|||| |||.|||| ..| |.. |.||| .|.|  |
lrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrprkk
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 9-298 9.6e-107 349.6 In-house 3-295 (297) alignment 
Range on Protein: 9-298
Range on HMM: 3-295/297.0
DNIISRLLEVRGSKPGKNVQLTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLA
|.||  .|     .      .||  .  | . . ..| .|  ..|..||.|.|||.|||. ||||||  ||.|| .||||||||||||. |.||| ||||
dsiiidvlsasthekllskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivllla

YKIKYPENFFLLRGNHECASINRIYGFYDECKRRYN-IKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSP---DLQSMEQIRRIMRPTDVpDQGLLCDLL
||.|.| |.|||||||||  .|..||||.||..||. .... .| | || ||.. .| .||.| ||||||   .  ... .|.| |.|.   ..|..|||
ykvkfpgnlfllrgnhecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadll

WSDPDKDVTGWGENDRGVSFTFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILKPA
|.||   ..|. ||.||    || . | |   . .|||.|||||||.||||||| |.|||.|||| |||.|||. ..|..|| | |||.||.|.
wadpisglsgfmenqrgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilrpt
subfamily_PPP2C_pd Subfamily PPP2C 26-301 8.4e-105 343.1 In-house 14-289 (290) alignment 
Range on Protein: 26-301
Range on HMM: 14-289/290.0
NVQLTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHE
  ||.|||.| ||.| .||. ..  . |...|. .|||||||..||| ||  ||  |..||||||||||||  |.||..|| | |..|.|   .||||||
ckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhe

CASINRIYGFYDECKRRY-NIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDkDVTGWGENDRGVSF
   | ..||||||| |.| | ..|| ||| |..||..|..||.||| |||||| ......|| . |  .||..| |||||||||| | .|||  .||  .
srqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpd.drggwgisprgagy

TFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILKPADKK
||| ..  || .. .| || ||||.| .||..  .|..||.|||||||    | .... .|..|  ||   .|| ..
tfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpaprr
subfamily_PPP4C_pd Subfamily PPP4C 29-298 1.7e-104 342.1 In-house 16-285 (288) alignment 
Range on Protein: 29-298
Range on HMM: 16-285/288.0
LTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECAS
..|.|.| ||.|.|||.. .  . ....|  .|||.|||.||||.||. ||  || |||||||.||||. |.||. ||||.|..||..  |.|||||. .
ikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrq

INRIYGFYDECKRRY-NIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDkDVTGWGENDRGVSFTFG
| ..||||||| |.| ....|.  |. |. |..|||||.|||| ||||||.......|| | | ..||..| |||||||||. |..||.   ||  . ||
itqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpe.daegwavsprgagylfg

PEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILKPA
 .||..| .. |..|||||||.| .|| .  .....|..||||||    |  ... .||.|   |.|.. |
sdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaa
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 26-300 5e-101 330.6 In-house 5-279 (281) alignment 
Range on Protein: 26-300
Range on HMM: 5-279/281.0
NVQLTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHE
.||.|. ||. . .. . || ..  | |...| .. ||.|.|. || ||||  | .||  ..|||||||||.||||.. ||...||.|... .|||||||
kvqytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnhe

CASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVTGWGENDRGVSFT
 ||.|.||||| ||. .| ..||  |  ||| ||..| |.... | ||||||.| .....| . .| . .|.||. ||||.|||..| .| .  ||.|||
iasvnkiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssft

FGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILKPADK
|| .|| .   . ...|| |||||| |||| .. |.|.|.||.||||  . ||.....|||||  |.. | || .
fGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpase
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 84-298 4.6e-98 321.3 In-house 101-315 (317) alignment 
Range on Protein: 84-298
Range on HMM: 101-315/317.0
SNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSME
..|||||||||||  |.| . ||.|.|..||.. ||||||||  ..|. |||| |.|.||. .|...|   ||.||..|....||.| |||.| .| ...
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldlk

QIRRIMRPTDVPDQGLLCDLLWSDPDKDVTGWGENDRGVSFTFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMT
|. .. ||.|.|| |.|.|| |.|||..|.|. |  || .. ||.. | .||.|.||||. |||||||||||||| |.|||.||||.|||..||......
qldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavls

VDETLMCSFQILKPA
||. |..|...|.| 
vdkklkisinvlrpe
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 28-300 4.7e-97 317.4 In-house 9-284 (287) alignment 
Range on Protein: 28-300
Range on HMM: 9-284/287.0
QLTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECA
 .....|  . .| .||.   | |||.|||..|.||.|||. ||||.|.  | .|. .||||||||||| .||| . ||...||.||..  |||||||. 
afsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevk

SINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVP--DQGLLCDLLWSDPDKDVTGWGEND-RGVSF
 ||..|||..| ||... .|.|.| | |. ||. |.....|.| |||.||.|.|..... . .||     |.||  ||||.||.||  .   |  |..| 
kinklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisv

TFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILKPADK
 || ..| ..|.| |.||| |||.|.|.||.|.....|||.|||| |.||  | |....|...|  ||  ||| | 
vfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkpedf
subfamily_PPP6C_pd Subfamily PPP6C 28-296 5.2e-97 317.5 In-house 14-282 (290) alignment 
Range on Protein: 28-296
Range on HMM: 14-282/290.0
QLTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECA
 |.|...| ||..  ...| .  .  ...|. .|||.|||.|||. ||  ||  |...|.||||.||||  ||||. .||. |.|||..  |||||||. 
ylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesr

SINRIYGFYDECKRRY-NIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPdKDVTGWGENDRGVSFTF
 | ..|||||||...| | . || .|. |. |..||||||...| |||||||.. ..||| | | ...| .| .|||.|||| .||  |   .||  . |
qitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdp.edvetwavsprgagylf

GPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILK
| .|. .|.|  .|.|||||||.||.|.... . .|||..||||||    |  |.......   .....|
gskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfk
subfamily_PPP3C_pd Subfamily PPP3C 26-289 1.1e-89 294.3 In-house 38-314 (452) alignment 
Range on Protein: 26-289
Range on HMM: 38-314/452.0
NVQLTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHE
. .|.|...  . ... ... ... |||.|||. ..||.|||.||||.||| || | ...|||||||||||  |.|..  |.| ||.||...||||||||
egrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhe

CASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVTGWG------E-N
|  .   . | .||| .|. .........|..||.||..... .|.||||||...|...|... |  ..| .|.||||||||| .|           . .
crhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpns

DRGVSFTFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAK------RQLVTLFSAPNYCGEFDNAGSMMTVDETLM
 || |. .. . |..||.| ||  | |||.. ..||. . |        |.||||||||.. ..| .... ...  |
vrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennvm
subfamily_PPG1_pd Subfamily PPG1 28-299 1.2e-88 290.3 In-house 13-297 (300) alignment 
Range on Protein: 28-299
Range on HMM: 13-297/300.0
QLTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECA
 | |. .| |..| .|.....  . |...|. . ||||||.||.| .|. ||  |..||||||||||||  |.||| ||.. |..||    |||||||  
llpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesr

SINRIYGFYDECKRRY--NIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPD---------KDVTG--
 | ..|||| || |.|  | ..|| .|. |. | .||||||.|.| ||||||. .|..||. . |  .||..| |.|||||||.          |  |  
qitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqh

WGENDRGVSFTFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILKPAD
. . .||  ...| .|| |||.. |.. | ||||.. .||. .   .| |..||||||    |  |.. . | .   |.. . | 
fvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeeap
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 29-298 2.5e-88 289.2 In-house 6-275 (280) alignment 
Range on Protein: 29-298
Range on HMM: 6-275/280.0
LTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECAS
.|  ||  . .    ||. .  | | |||.|. ||.| || |. |||.  |  || . .||||||||| | .| . ||.. ||.| .  .|||||||  |
mtgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetps

INRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVTGWGENDRGVSFTFGP
.|.||||| ||. .| . ||  |  ||| .|....| ....| ||||||.|  .. || | || .  |.||| ||||||| .   ||  . ||.|. || 
vnkiygfyvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgk

EVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILKPA
 || .  .  ..||| ||||||.||||..| |.|.|.|| |||| .| || ... ..  |  ||| | | 
gvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlipp
subfamily_PPP5C_pd Subfamily PPP5C 39-287 9.8e-86 280.7 In-house 44-298 (322) alignment 
Range on Protein: 39-287
Range on HMM: 44-298/322.0
QKSREIFLSQPILLELEAP----LKICGDVHGQYYDLLRLFEYGGFPPES-NYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIY
....|.. ..| |.|.. .    | .|||.|||.|||| .||  | | |.  ||| ||.||||  |.|.| .||..|. ||..||| |||||  ..|..|
leakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnkly

GFYDECKRRYNIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGL-SPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKdVTGWGENDRGVSFTFGPEVVA
|| .|.| .|. |. . ||. || ||.| .|.||.. .|||| | |  .....|.| | .. |..|||..||||||..  .| ..  |||...|||.|  
GfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqe.anGrspskrGvgvqfGpdvtk

KFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTV-DET
|||.. .|.|| |.|.| |.|||.  . .|.|.||||||| . .| |...|. .. 
kflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgdd
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 24-298 1.4e-85 279.8 In-house 11-289 (290) alignment 
Range on Protein: 24-298
Range on HMM: 11-289/290.0
GKNVQLTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGN
|    .....|  . .| .||.   | |||.|||. | ||.|||  .||| |.  |.||. ..|||||||||| .|||   ||. |||.|...  |||||
gvldafsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgn

HECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTD--VPDQGLLCDLLWSDPDK--DVTGWGEND
||.  .||.|||..|  |. . .||| . | |. |.. | ...||.| |||.|....| | .. . .|      |.||  ||||.||..  | |   .  
hevrkvnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkq

RGVSFTFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILKPA
|..|  || ... ..|.|  |.|| |||.| |.|..|  ...|||.|||| |.|.  | |...|| |.|  |. .||| 
raisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkpr
PPP_2 59-249 8.8e-84 273.1 In-house 2-197 (198) alignment 
Range on Protein: 59-249
Range on HMM: 2-197/198.0
KICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECK-RRYNIKLWKTFTDCFNC
..|||.|||..|||.||..|...||..||||||||||||.|||...||||.|..||....|||||||....|..|||..|.. .... |..|.....|..
tvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfel

LPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLL----WSDPDKDVTGWGENDRGVSFTFGPEVVAKFLHKHDLDLICRAHQV
||.||.||||....|||||.......||... |....|..|.|.|||    .|||... ... .. ||....|||.|....|.|..|.||.|||.|
LplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 59-249 1.1e-80 263.3 In-house 2-196 (197) alignment 
Range on Protein: 59-249
Range on HMM: 2-196/197.0
KICGDVHGQYYDL-LRLFEYGGFPP-ESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFN
 ..||.|||..|| |.|...||.|. |..|.||||||||||.|||...||||.|..||....|||||||..|.|..|||..|...... ...|...|.|.
tvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvfd

CLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVP-DQGLLCDL-LWSDPDKDVTGWGENDRGVSFTFGPEVVAKFLHKHDLDLICRAHQV
.||.||.||||....|||||..|.|...|.|| |....| ......|| ||||| .. .|. .. ||....|||.|. |||.|..|.||.|.|..
llplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 25-294 9e-78 254.5 In-house 16-288 (307) alignment 
Range on Protein: 25-294
Range on HMM: 16-288/307.0
KNVQLTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNH
...| |  |.. .  ... || |.  |.... |  . ||.|||. ||. .|   | |||. |.| |||||||  |||.| ||..||| ||||  ||||||
hkiqytkeefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnh

ECASINRIYGFYDECKR---RYNIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVTGWGENDRG
| | .|. ||||.||     .   ..|  |  ||| ||..|.|  ||.| |||||| |  ....|   .|   | .|.. |.||.|||  |  |    ||
eiarvnkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrg

VSFTFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQI
  |||| .|.    ..  ..|| ||||.. |||  .. |.|.|.|||| ||  . ||| .. |||||      
sgftfgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlva
PPP_5_Dcr2 59-250 8.2e-77 250.7 In-house 2-199 (199) alignment 
Range on Protein: 59-250
Range on HMM: 2-199/199.0
KICGDVHGQYYDL-LRLFEYGGFPP-ESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRR-YNIKLWKTFTDCF
 .|||.|||..|| |.||. ||.|. | .|.||||||||||.|||...||||.|..||....|||||||. ..|.||||..|.... .. |..|...|.|
tvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdvf

NCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVP-DQGLLCDL-LWSDPDKDVTG-WGENDRGVSFTFGPEVVAKFLHKHDLDLICRAHQVV
..||.||.||||....||||||...|.|....| |....| ..|  .|| ||||| ....| . .. ||....|||.|. |||.|..|.||.|.|...
dwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 85-302 1.1e-75 247.9 In-house 121-338 (339) alignment 
Range on Protein: 85-302
Range on HMM: 121-338/339.0
NYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQ
 |||||||||||  |.| . || | |. ||.  .|||||||  |.|  |||| | . ||. .|.. | . || .|..|.|.. |.| |||.|  | |..|
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfnq

IRRIMRPTDVPDQGLLCDLLWSDPDKDVTGWGENDRGVSFTFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTV
.  . || ..|| |.| || |.|||    |.    || || |||  .  ||.| ||... | |||||||||||  |.|||.||||||||. ||. .....
fsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfsi

DETLMCSFQILKPADKKK
|. |  | ....|  . |
dkklkisinvfrpesrdk
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 51-299 7.3e-74 241.7 In-house 2-257 (263) alignment 
Range on Protein: 51-299
Range on HMM: 2-257/263.0
LLELEAPLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNI-----
||||.||..|||| |||| ||||.|.  |   ...||||||||||| .||| | ||.. |.  | ...|||||||  .||. |||. | |.|..      
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

KLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPD-QGLLCDLLWSDPDKDVTGWGEND-RGVSFTFGPEVVAKFLHKHDLDLI
 ... | . |. .|..||. ..|.| |||.|| |.|...|| |  | .    . | |||||.||.||  |.  |  | .|  || . |  . .. |.|||
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidli

CRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILKPAD
 ||||||| || ||| |.|.|.|||  |  |. |  ... |.. |  ||  ||| |
vrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkped
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 28-297 5e-69 225.8 In-house 5-299 (302) alignment 
Range on Protein: 28-297
Range on HMM: 5-299/302.0
QLTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYG------------GFpPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPE
....||.  |...  | .  .  | |. .|. | ||.|||. ||.|.. .             .|  .. ..|||||||||..|.| |||..|.|. ||.
eysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysf.ssdkfvflGdyvdrGsksieciclvfalkvlypt

NFFLLRGNHECASINRIYGFYDECKRRY----NIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRP-TDVPDQGLLCDLLWSDPD-
|. |||||||. .||  ||| .| . |.      ..|. | ..|  .|.||.. |||.| |||.|| |.|.|.|..| || ..| .. |  |||..||  
nyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpld

KD-------VTGWGE-NDRGVSFTFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILKP
 .          . . . ||.|..|    | .. .. .|.|| ||||..  |. |||...|.|.||||.|  | || |... ||     | ..|..
vqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrn
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 27-296 1.1e-68 224.7 In-house 5-299 (302) alignment 
Range on Protein: 27-296
Range on HMM: 5-299/302.0
VQLTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYG------------GFpPESNYLFLGDYVDRGKQSLETICLLLAYKIKYP
 ....||.  |...  | .  .  | |. .|. | ||.|||. ||.|.. .             .|  .. ..|||||||||..|.| |||..|.|. ||
keysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysf.ssdkfvflGdyvdrGsksieciclvfalkvlyp

ENFFLLRGNHECASINRIYGFYDECKRRY----NIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIRRIMRP-TDVPDQGLLCDLLWSDPD
.|. |||||||. .||  ||| .| . |.      ..|. | ..|  .|.||.. |||.| |||.|| |.|.|.|..| || ..| .. |  |||..|| 
tnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpl

-KD-------VTGWGE-NDRGVSFTFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSFQILK
  .          . . . ||.|..|    | .. .. .|.|| ||||..  |. |||...|.|.||||.|  | || |... ||     | ..|.
dvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlr
subfamily_PPPLV_pd Subfamily PPPLV 36-287 4.1e-58 190.0 In-house 4-278 (290) alignment 
Range on Protein: 36-287
Range on HMM: 4-278/290.0
GLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLL----RLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINR
 ||... .|....  ||||..|  . ||.||.| ||      |.  |     ...||||||||||. |.| |. ||| |. ||  ..|||||||  |.  
slcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqe

IYGFYDECKRRYNIKL---WKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQI---RRIMR--PTDVPDQGLLCDLLWSDPDKDV-----------
 . .. |.. ..  .|   |..|...|. ||.||.||.|.||.|.|.    ..  .|   . |.   . |.    |  |.|||||..|            
sieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvln

TGWGEND-RGVSFTFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGsMMTVDET
 |. .|| || .  |. . . .||.. .|. . |||.| | |...  | .|.|.||. .|||  ..|  .. ||. 
eGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssneaa.lilvdkk
Metallophos Calcineurin-like phosphoesterase 58-249 9.2e-46 149.6 Pfam-A 3-198 (200) alignment 
Range on Protein: 58-249
Range on HMM: 3-198/200.0
LKICGDVHGQYYDL----LRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLL--LAYKIKYPENFFLLRGNHECASINRIYGFYDECK-----------
  ..||.||...||    |.|.. .. ..  ..|||||.||||. |.||..||  |..|...| ..||||||||. ..|  |||..|.            
ilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglangee

-----------------------RRYNIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLSPDLQSMEQIrrimrptdvpdqgllcdllwsdpdkdvtgwge
                        ... . .  . ..|..|| .|..| ||...||.||....| ..|                                
eyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi................................

ndrgVSFTFGPEVVAKFLHKHDLDLICRAHQV
     |. |||... |.| |...||..|.|. 
....gselfgpdalekllekygvdlvlrGHtH
subfamily_PPP7C_pd Subfamily PPP7C 58-190 1.8e-38 125.3 In-house 66-201 (383) alignment 
Range on Protein: 58-190
Range on HMM: 66-201/383.0
LKICGDVHGQYYDLLRLFEYGGFPPE-SNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRY---NIKLWKTFTD
. .|||.||.  ||| ..   |.| |  .|.| ||.|||||.|.| ...|||. . ||....| |||||   .|  |||  | . .|   . |. ... |
vtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlled

CFNCLPVAAIIDEKIFCCHGGLSpDLQSMEQIRRIMR
 |  ||.|..|||||. .|||.| |  ..| . .| |
vfawlplatlidekilivhGGis.dktdlelldkier
subfamily_PPP7C_pd Subfamily PPP7C 200-292 1.7e-20 66.1 In-house 237-329 (383) alignment 
Range on Protein: 200-292
Range on HMM: 237-329/383.0
LCDLLWSDPDKDVTGWGENDRGVSFTFGPEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGSMMTVDETLMCSF
. |.||||| ..   . .  ||    |||.| .|.|.|..|.|. |.|.   .||||  .....|.||| ||  |  | |. . . ..|.  .
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltpri
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 29-82 5.6e-17 54.9 In-house 9-62 (317) alignment 
Range on Protein: 29-82
Range on HMM: 9-62/317.0
LTESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPP
..|.|.  || ..||.| ..|. ||||||..|.||.|||. ||| |..  |.| 
fkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwpl
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 31-83 1.6e-12 40.1 In-house 13-65 (339) alignment 
Range on Protein: 31-83
Range on HMM: 13-65/339.0
ESEIKGLCQKSREIFLSQPILLELEAPLKICGDVHGQYYDLLRLFEYGGFPPE
 .|.  ||...||.  |.||.|.||||. . ||.|||. ||| ...  |.|  
aaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmngwpls
subfamily_YNL217W_pd Subfamily YNL217W 59-177 1.6e-08 27.3 In-house 13-138 (235) alignment 
Range on Protein: 59-177
Range on HMM: 13-138/235.0
KICGDVHGQYYDLLRLFE--YGGFPPESNYLFLGDYVDRGKQSLETICLLlaykikYPENFFLLRGNHECASINRIygfydECKRRY-------------
 . ||||| | .|..|..   ||  ..   ...|| ...| .|.|.. ..        ..   ..|||| . . ..     .  ..              
lvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllay.....kwvkkpkgaeplefsskfs

NI--KLWKTFTDCFNCLPVA-AIIDEKIFCCHGGLSP
 .  || |  ..    |. .  |  ....  |.||.|
flesklskadmeyarelgfsldipsdellvvhaGlvp