Gene gsp-4 in Caenorhabditis elegans

Synonym: CELE_T03F1.5, gsp-4

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily CelePPP-sf4
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP108_AA protein Get Run
CeleP108_AA_3-302 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 5-303 7.7e-205 671.7 In-house 1-299 (299) alignment 
Range on Protein: 5-303
Range on HMM: 1-299/299.0
IDVDNLMSRLLNVGMSGGRLTTSVNEQELQTCCAVAKSVFASQASLLEVEPPIIVCGDIHGQYSDLLRIFDKNGFPPDINFLFLGDYVDRGRQNIETICL
.|||.|.|.|||||||..|||.||.||||||.||||||||||||||||||.|||||||||||||||||||||.|||||.|||||||||||||||.|.|.|
ldvdellskllnvgmsekrltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitl

MFCFKIKYPENFFMLRGNHECPAINRVYGFYEECNRRYKSTRLWSIFQDTFNWMPLCGLIGSRILCMHGGLSPHLQTLDQLRQLPRPQDPPNPSIGIDLL
..||||||||.||||||||||||||||||||||||.|||||||||||||.|..|||.||||||||||||||||.||||||||.|.|||||||||.|||||
llcfkikyperffmlrgnhecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidll

WADPDQWVKGWQANTRGVSYVFGQDVVADVCSRLDIDLVARAHQVVQDGYEFFASKKMVTIFSAPHYCGQFDNSAATMKVDENMVCTFVMYKPTPKSLR
||||||.||.|.||.|||||||||||||||.||||||||||||||||||||||||||.||||||||||||||||||.||||||.|||||..|||||||.
wadpdqsvkdwlanvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpkslk
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 6-301 2.5e-168 551.6 In-house 2-297 (298) alignment 
Range on Protein: 6-301
Range on HMM: 2-297/298.0
DVDNLMSRLLNVGMSGGRLTTSVNEQELQTCCAVAKSVFASQASLLEVEPPIIVCGDIHGQYSDLLRIFDKNGFPPDINFLFLGDYVDRGRQNIETICLM
.||.|....|.|..|. .||....|.........||..|..|.||.||..|| ||||||||||||||.|||.||||| |.|||||||||||||.|.|.|.
evdellievlsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivll

FCFKIKYPENFFMLRGNHECPAINRVYGFYEECNRRYKSTRLWSIFQDTFNWMPLCGLIGSRILCMHGGLSPHLQTLDQLRQLPRPQDPPNPSIGIDLLW
...|.|||.|||.|||||||.||||||||||||.|||||.||.. |||.||..||..|||.||||||||||..|..|||||.| ||.|....|. |||||
laykvkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllw

ADPDQWVKGWQANTRGVSYVFGQDVVADVCSRLDIDLVARAHQVVQDGYEFFASKKMVTIFSAPHYCGQFDNSAATMKVDENMVCTFVMYKPTPKS
|||...||||..|.||||.|||.|||.|....||||||.||||||||||||||.||.||||||||||||||||||.|||||..|..|...||. |.
adpenavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpekke
subfamily_PPP1C_pd Subfamily PPP1C 25-299 3.6e-128 419.6 In-house 7-280 (282) alignment 
Range on Protein: 25-299
Range on HMM: 7-280/282.0
TTSVNEQELQTCCAVAKSVFASQASLLEVEPPIIVCGDIHGQYSDLLRIFDKNGFPPDINFLFLGDYVDRGRQNIETICLMFCFKIKYPENFFMLRGNHE
.....|.|... .. |.... ||. |||.| |. ..|||||||.||||.|...|.||. |.||||||||||.| .|||.|....|||||||.|.||||||
evklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhe

CPAINRVYGFYEECNRRYKSTrLWSIFQDTFNWMPLCGLIGSRILCMHGGLSPHLQTLDQLRQLPRPQDPPNPSIGIDLLWADPDQWVKGWQANTRGVSY
.  |||.||||.||.|||... || .|.|.||..||. |. ..|||.||||||.|. |.|.|.. || . |. .. .||||.|||. |.||..|.||||.
sasinriyGfydeckrrysik.lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsf

VFGQDVVADVCSRLDIDLVARAHQVVQDGYEFFASKKMVTIFSAPHYCGQFDNSAATMKVDENMVCTFVMYKPTP
.||.|||...... |.||. ||||||.|||||||....||.||||.|||.|||..| ..|||.....| . ||. 
tfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpak
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 24-299 1.9e-125 410.6 In-house 2-276 (280) alignment 
Range on Protein: 24-299
Range on HMM: 2-276/280.0
LTTSVNEQELQTCCAVAKSVFASQASLLEVEPPIIVCGDIHGQYSDLLRIFDKNGFPPDINFLFLGDYVDRGRQNIETICLMFCFKIKYPENFFMLRGNH
|.. ..| ....     | ... ||...||. |. ||||.||||.||||.|.. .|||| |.||||||||||||..| |.|....|..||.||..|||||
llacikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnh

ECPAINRVYGFYEECNRRYKsTRLWSIFQDTFNWMPLCGLIGSRILCMHGGLSPHLQTLDQLRQLPRPQDPPNPSIGIDLLWADPDQWVKGWQANTRGVS
|.  ||| |||..|. |||.   |.. ||. .. .||. |.. ||||||||||..|..||.|..| || |... ..  |||||||.. | || .|.||||
evisinrkygfkdevkrrys.lalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvs

YVFGQDVVADVCSRLDIDLVARAHQVVQDGYEFFASKKMVTIFSAPHYCGQFDNSAATMKVDENMVCTFVMYKPTP
..||..|| |.. .|||||.|| |||||||||||| ||.||.||||.|.|.|||||| ..|||... .| . ||  
vifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpal
PP2Ac_SM00156 29-298 5.2e-120 392.5 In-house 2-270 (271) alignment 
Range on Protein: 29-298
Range on HMM: 2-270/271.0
NEQELQTCCAVAKSVFASQASLLEVEPPIIVCGDIHGQYSDLLRIFDKNGFPPDINFLFLGDYVDRGRQNIETICLMFCFKIKYPENFFMLRGNHECPAI
...|. ...  .|... ....|.||..|..|.||||||..||||.....|.||. ...||||||||| |.||.|.|.|..||.|||....||||||.. .
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

NRVYGFYEECNRRYkSTRLWSIFQDTFNWMPLCGLIGSRILCMHGGLSPHLQTLDQLRQLPRPQDPPNPSIGIDLLWADPDQWVKGWQANTRGVSYVFGQ
|..|||.||..|.| .......|...|...||. |..|.||||||||||.|..||..|.| |....|. .. |||||.||.| .||.|...||.|.|||.
nkiygfeeevkrky.gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFge

DVVADVCSRLDIDLVARAHQVVQDGYEFFASKKMVTIFSAPHYCGQFDNSAATMKVDENMVCTFVMYKPT
|.| .........|. |||.||..||||||.||.|||||||.||..|.|.||..||..|. ......|..
davkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 31-303 1.5e-119 391.6 In-house 6-279 (284) alignment 
Range on Protein: 31-303
Range on HMM: 6-279/284.0
QELQTCCAVAKSVFASQASLLEVEPPIIVCGDIHGQYSDLLRIFDKNGFPPDINFLFLGDYVDRGRQNIETICLMFCFKIKYPENFFMLRGNHECPAINR
....|    | |.|  |  |.||. || .|||||||.|||||.|||||||   |.||||||||||.. .||| |.|..|. .|. ||||||||||  ||.
edvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslink

VYGFYEECNRRYKSTRLWSIFQDTFNWMPLCGLIGSRILCMHGGLSPHLQTLDQLRQLPRPQDPPNPS-IGIDLLWADPDQWVKGWQANTRGVSYVFGQD
.|||||||.|||.   ..  |.  |  |||  |.| ||||||||.|  || . ||| . || | |.|  . ||.||.|| .. |||. |.|||||||| |
iygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsd

VVADVCSRLDIDLVARAHQVVQDGYEFFASKKMVTIFSAPHYCGQFDNSAATMKVDENMVCTFVMYKPTPKSLR
 .  .  ||.|||| |||||||||||||| ...||||||| |||||||.|| | |..|.||.||. .|  |  |
alrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrprkkiar
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 7-298 1.3e-115 378.7 In-house 2-295 (297) alignment 
Range on Protein: 7-298
Range on HMM: 2-295/297.0
VDNLMSRLLNVGMSGGRLTTSVNEQELQTCCAVAKSVFASQASLLEVEPPIIVCGDIHGQYSDLLRIFDKNGFPPDINFLFLGDYVDRGRQNIETICLMF
||...  .|        |.  . |. .     .| .|| .| |..||. || ||||||||. ||||.| . |.||  |.|||||||||||  |||| |..
vdsiiidvlsasthekllskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlll

CFKIKYPENFFMLRGNHECPAINRVYGFYEECNRRYKSTRLWSIFQDTFNWMPLCGLIGSRILCMHGGLSP---HLQTLDQLRQLPRPQDPPNpSIGIDL
..|.|.| |.|.|||||||  .|.||||||||..||.| |... ||| |||.||.||| ..||||||||||   .  ||| ||.. |...  . ..  ||
aykvkfpgnlfllrgnhecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierstegke.rlvadl

LWADPDQWVKGWQANTRGVSYVFGQDVVADVCSRLDIDLVARAHQVVQDGYEFFASKKMVTIFSAPHYCGQFDNSAATMKVDENMVCTFVMYKPT
|||||   . |.  | ||    ||.| | ..|| ...|||.|||||||||||||| .|.||||||||||||||| || | .||.. |.| . .||
lwadpisglsgfmenqrgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilrpt
subfamily_PPZ_pd Subfamily PPZ 5-297 9.8e-108 353.2 In-house 1-293 (300) alignment 
Range on Protein: 5-297
Range on HMM: 1-293/300.0
IDVDNLMSRLLNVGMSGGRLTT-SVNEQELQTCCAVAKSVFASQASLLEVEPPIIVCGDIHGQYSDLLRIFDKNGFPPDINFLFLGDYVDRGRQNIETIC
.|.|... .||. | .  |     ....|.   |  |. .| .| .|||. |.. . ||.||||.||||.| | ||||  |.||||||||||.|..||| 
vdideiiqklldagyaakrtknvclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletil

LMFCFKIKYPENFFMLRGNHECPAINRVYGFYEECNRRYKsTRLWSIFQDTFNWMPLCGLIGSRILCMHGGLSPHLQTLDQLRQLPRPQDPPNPSIGIDL
|..|.|||||||||.|||||||  . ||||||.||.|| .  ..|  | |||| .||. ..  .|.|.|||||| |...|..|.. || | |.  .  ||
lllcykikypenffllrgnhecanvtrvygfydeckrrcn.ikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindl

LWADPDQWVKGWQANTRGVSYVFGQDVVADVCSRLDIDLVARAHQVVQDGYEFFASKKMVTIFSAPHYCGQFDNSAATMKVDENMVCTFVMYKP
||.|| .  . |. | |||||.. .  .  .  .. .|||.||| ||.||||||  . .||.|||| |||.|||  | | | | ..|.| .  |
lwsdptdssnewednergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldp
0045823 Metallo-dependent phosphatases 27-302 1.2e-106 350.1 In-house 42-328 (473) alignment 
Range on Protein: 27-302
Range on HMM: 42-328/473.0
SVNEQELQTCCAVAKSVFASQASLLEVEPPIIVCGDIHGQYSDLLRIFDKNGFPPDINFLFLGDYVDRGRQNIETICLMFCFKIKYPENFFMLRGNHECP
 ..| .|   .  ||...... .|||....|.|.||||||. ||||...|.||||. ...||||.|||| ...|...|....|||||.|.|.||||||. 
llpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkikypgnvfllrGNHElr

AINRVYGFYEECNRRYkSTRLWSIFQDTFNWMPLCGLIGSRILCMHGGLSPHLQTLDQLRQLPRPQDPPNPSIGIDLLWADPdQWVKG--------WQAN
..| .|||..|. ..| . .|.. |.. ....||. .||..||..||||||.|..|||.|...||...|. ..  ||||.|| ....|        .. .
llnglygfgdetleky.gedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdP.weddgdgllrlrffgns

TRGVSYVFGQDVVADVCSRLDIDLVARAHQVVQDGYEFFASKK------MVTIFSAPHYCGQFDNSAATMKVDENMvCTFVMYKPTPKSL
 ||..|.||.|.| ..... ..||. |.|..|..|||..  .|       .|.||||.|||...| || ...||.. ..|....|.|  |
prgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsphpl
0049330 Metallo-dependent phosphatases 4-301 1.2e-105 346.0 In-house 6-302 (309) alignment 
Range on Protein: 4-301
Range on HMM: 6-302/309.0
TIDVDNLMSRLLNVGMSGGRLTTSVNEQELQTCCAVAKSVFASQASLLEVEPPIIVCGDIHGQYSDLLRIFDKNGFPPDINFLFLGDYVDRGRQNIETIC
......|. .||.. ..  . .  ..|.|| . .  ||... |. .|||.. .|.|.||||||. ||||...|.||||. ...||||.|||| ...|...
pllllelilslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevll

LMFCFKIKYPENFFMLRGNHECPAINRVYGFYEECNRRYKsTRLWSIFQDTFNWMPLCGLIGSRILCMHGGLSPHLQTLDQLRQLPRPQDPPNPSIGIDL
|....|..||.|.|.||||||. ..|..|||..|. |.|   .||  |.|.....||. .||..|||.||||||.|..|||.|.| ||...|. ..  ||
lllalkllypdnvfllrGNHElrllnglygfgdetlrkyg.aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdl

LWADPDQWVKGWQANTRGVSYVFGQDVVADVCSRLDIDLVARAHQVVQDGYEFFASKKMVTIFSAPHYCGQFDNSAATMKVDENMVCTFVMYKPTPKS
||.||. ...|.. |.||...||| ..| ... ....||. |.|..|..||..|...|..|.||||.|||...| .| ...||..|..|....|.|  
lwsdplpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpll
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 29-300 1.2e-104 342.5 In-house 9-279 (281) alignment 
Range on Protein: 29-300
Range on HMM: 9-279/281.0
NEQELQTCCAVAKSVFASQASLLEVEPPIIVCGDIHGQYSDLLRIFDKNGFPPDINFLFLGDYVDRGRQNIETICLMFCFKIKYPENFFMLRGNHECPAI
 ..|...    ....|... .| |...|| | ||.|.|. || |.|.  | .|.  ..||||||||| |..|.. |.|..||.|... ..|||||| ...
tkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasv

NRVYGFYEECNRRYkSTRLWSIFQDTFNWMPLCGLIGSRILCMHGGLSPHLQTLDQLRQLPRPQDPPNPSIGIDLLWADPDQWVKGWQANTRGVSYVFGQ
|..||||.||  .|  . ||  ||  || .|. .||  |.||||||||| | .||.||. |.| ....  . |||||||||. |..|.| .||.|..||.
nkiygfyvecvtky.GeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfGk

DVVADVCSRLDIDLVARAHQVVQDGYEFFASKKMVTIFSAPHYCGQFDNSAATMKVDENMVCTFVMYKPTPK
.|| ||| ||...|. ||||||||||| ....|..|.||.| || .. |.|| .||||..  ..| . |...
nvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpase
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 28-297 2.2e-102 335.3 In-house 8-282 (284) alignment 
Range on Protein: 28-297
Range on HMM: 8-282/284.0
VNEQELQTCCAVAKSVFASQASLLEVEPPIIVCGDIHGQYSDLLRIFDKNGFP------PDINFLFLGDYVDRGRQNIETICLMFCFKIKYPENFFMLRG
..|.||   |  |. .|  .   ||.| |. ..||||||. ||| ..| ||.|       . ..||||||||||   || | |.|..|...|.. |.|||
lkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrg

NHECPAINRVYGFYEECNRRYkSTRLWSIFQDTFNWMPLCGLIGSRILCMHGGLSPHLQTLDQLRQLPRPQDPPNPSIGIDLLWADPDQWVKGWQANTRG
|||   .|. ||||.||..|| |..|. .|| .|| |||| .....|.|||||.| .|  |.|| .| || | |.  .  || ||||.. |.|..   ||
nhesrpvnmqygfyleckkry.sealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesprg

VSYVFGQDVVADVCSRLDIDLVARAHQVVQDGYEFFASKKMVTIFSAPHYCGQFDNSAATMKVDENMVCTFVMYKP
   |||.. | . . . ..||| ||||||.||||||| .|.||||||| ||||.|| || ..|||..|..|.. ||
agkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkp
PPP_3 29-296 9.1e-102 332.7 In-house 3-270 (271) alignment 
Range on Protein: 29-296
Range on HMM: 3-270/271.0
NEQELQTCCAVAKSVFASQASLLEVEPPIIVCGDIHGQYSDLLRIFDKNGFPPDINFLFLGDYVDRGRQNIETICLMFCFKIKYPENFFMLRGNHECPAI
.|.||.. .  .|... ....|.|.. |. ||||||||. |||..|.. |..|. ..|||||||||| . .|...|....|||||.....||||||.  |
senelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrqi

NRVYGFYEECNRRYKSTRLWSIFQDTFNWMPLCGLIGSRILCMHGGLSPHLQTLDQLRQLPRPQDPPNPSIGIDLLWADPDQWVKGWQANTRGVSYVFGQ
|.||||..|. .......... .|..|...||. || ...|..||||||....|||...| |... |. .  .|||. ....  .|.. ..||....||.
nkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFgp

DVVADVCSRLDIDLVARAHQVVQDGYEFFASKKMVTIFSAPHYCGQFDNSAATMKVDENMVCTFVMYK
||....... ...|..|||.....|||... .|.||.||||.||....| .| .|..|.. ..|....
dvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 26-298 9e-101 329.6 In-house 8-282 (287) alignment 
Range on Protein: 26-298
Range on HMM: 8-282/287.0
TSVNEQELQTCCAVAKSVFASQASLLEVEPPIIVCGDIHGQYSDLLRIFDKNGFPPDINFLFLGDYVDRGRQNIETICLMFCFKIKYPENFFMLRGNHEC
 ....... .    .....    .||||| || ..||||||. ||||||.. | .|....|||||||||| . .| . |.|..||.||..  .||||||.
dafsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhev

PAINRVYGFYEECNRRYKsTRLWSIFQDTFNWMPLCGLIGSRILCMHGGLSPHLQTLDQLRQLPRPQDPPNP--SIGIDLLWADPDQWVKGWQAN-TRGV
 .||..|||.|| .|...  ||.  |.| |. .|||  .. ||||||||.||.|..||.|. |..|. | .    . .|||||||..  |. . |  |..
kkinklyGfkeelkrkrq.erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkirai

SYVFGQDVVADVCSRLDIDLVARAHQVVQDGYEFFASKKMVTIFSAPHYCGQFDNSAATMKVDENMVCTFVMYKPT
| |||. .| |.. .|||||. |||.|...||.|.. |..||.||||.|.|.  | .| ..|.. .  .||. || 
svvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkpe
0053225 Metallo-dependent phosphatases 12-299 4.3e-97 318.0 In-house 6-292 (293) alignment 
Range on Protein: 12-299
Range on HMM: 6-292/293.0
SRLLNVGMSGGRLTTSVNEQELQTCCAVAKSVFASQASLLEVEPPIIVCGDIHGQYSDLLRIFDKNGFPPDINFLFLGDYVDRGRQNIETICLMFCFKIK
 .||.. ..  .|.  ..|.|| . .  ||... .. .|||.. .|.|.|||||.. |||....| ||||. ...||||.|||| ...|...|....|..
lllldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkll

YPENFFMLRGNHECPAINRVYGFYEECNRRYKSTRLWSIFQDTFNWMPLCGLIGSRILCMHGGLSPHLQTLDQLRQLPRPQDPPNPSIGIDLLWADPDqW
||.|...||||||.  .| .|||..|. |.| . .||  ..|.....||. |||..||..||||||.| .|||.| . ||...|. ..  |||| ||| .
ypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpd.l

VKGWQANTRGVSYVFGQDVVADVCSRLDIDLVARAHQVVQDGYEFFASKKMVTIFSAPHYCGQFDNSAATMKVDENMVCTFVMYKPTP
..||  . ||...||| ..| ... . ..||. |.||||.|||... ..|.||.||||.|.|...| .| ...||..|..|....|..
wsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapvl
PPP_1 29-284 4.7e-96 314.1 In-house 2-264 (264) alignment 
Range on Protein: 29-284
Range on HMM: 2-264/264.0
NEQELQTCCAVAKSVFASQASLLEVEPPIIVCGDIHGQYSDLLRIFDKNGFPPDINFLFLGDYVDRGRQNIETICLMFCFKIKYPENFFMLRGNHECPAI
.|.||.. .  .|... ..  ||||. .| ||||||||. |||..| . |..|. |.|||||||||| . .|...|....|.|||...|.||||||.  .
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

NRVYGFYEECNRRYKSTRLWSIFQDTFNWMPLCGLIGSRILCMHGGLSPHLQTLDQLRQLPRPQDPPNPSIGIDLL-------WADPDQWVKGWQANTRG
..||||..|. ... |........|.|...||. ||  .||..||||||.|..||| |.. | .. |. .   |||       . |...  .... ..||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

VSYVFGQDVVADVCSRLDIDLVARAHQVVQDGYEFFASKKMVTIFSAPHYCGQFDNSAATMKV
..|.||.||....... ...|..|||.|...||||....|.||||||. |. ...| .| .|.
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvkl
subfamily_PPP2C_pd Subfamily PPP2C 27-301 6.8e-93 304.0 In-house 16-289 (290) alignment 
Range on Protein: 27-301
Range on HMM: 16-289/290.0
SVNEQELQTCCAVAKSVFASQASLLEVEPPIIVCGDIHGQYSDLLRIFDKNGFPPDINFLFLGDYVDRGRQNIETICLMFCFKIKYPENFFMLRGNHECP
...|.|... |  || ...... . ||. |. ||||.|||. ||| .|   |  || |.||||||||||   .||..|. ..|..|.|   .||||||  
qleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhesr

AINRVYGFYEECNRRYKSTRLWSIFQDTFNWMPLCGLIGSRILCMHGGLSPHLQTLDQLRQLPRPQDPPNPSIGIDLLWADPDQwVKGWQANTRGVSYVF
 | .|||||.|| |.| .. .| .| | |...||..|. ..|.|.||||||...|||..|.| | |. |.     ||||.|||.  .||.   ||  | |
qitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpdd.rggwgisprgagytf

GQDVVADVCSRLDIDLVARAHQVVQDGYEFFASKKMVTIFSAPHYCGQFDNSAATMKVDENMVCTFVMYKPTPKS
|.|.  .   . .. |.|||||.| .||..   ...||||||| || .  | || ...|...  .|. ..|.|..
gkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpaprr
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 32-299 1e-92 303.6 In-house 10-276 (280) alignment 
Range on Protein: 32-299
Range on HMM: 10-276/280.0
ELQTCCAVAKSVFASQASLLEVEPPIIVCGDIHGQYSDLLRIFDKNGFPPDINFLFLGDYVDRGRQNIETICLMFCFKIKYPENFFMLRGNHECPAINRV
|. .   . ...|  .. | | | || | |||| || |. |.||  |  |. ...||||||||| | || . |.||.||.| .  ..|||||| |..|..
eiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnki

YGFYEECNRRYKsTRLWSIFQDTFNWMPLCGLIGSRILCMHGGLSPHLQTLDQLRQLPRPQDPPNPSIGIDLLWADPDQWVKGWQANTRGVSYVFGQDVV
|||| ||. .|    ||  ||  || ||..|||  |.||||||||| |  || .|..||| .| .  . |||||.|| .  .||  . ||.||.||. ||
ygfyvecqykyg.vglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkgvv

ADVCSRLDIDLVARAHQVVQDGYEFFASKKMVTIFSAPHYCGQFDNSAATMKVDENMVCTFVMYKPTP
 . |  |.|||. |||||||||||..| ....|.|| | || || |.|| . .. |.  .|    | |
eqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlippp
subfamily_PPP4C_pd Subfamily PPP4C 26-298 5.2e-92 301.1 In-house 14-285 (288) alignment 
Range on Protein: 26-298
Range on HMM: 14-285/288.0
TSVNEQELQTCCAVAKSVFASQASLLEVEPPIIVCGDIHGQYSDLLRIFDKNGFPPDINFLFLGDYVDRGRQNIETICLMFCFKIKYPENFFMLRGNHEC
  ..|.|... || |. ..  .. . .|. |..||||||||. |||..|. .|  |. |.|||||.||||   .||. |. ..|..||..  ..|||||.
elikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhes

PAINRVYGFYEECNRRYKSTRLWSIFQDTFNWMPLCGLIGSRILCMHGGLSPHLQTLDQLRQLPRPQDPPNPSIGIDLLWADPDQwVKGWQANTRGVSYV
  | .|||||.|| |.| |...|    . |....|. .|  .|.|.||||||...|||..|.. | |. |.  . .||||.||.. ..|| .  ||  |.
rqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdped.aegwavsprgagyl

FGQDVVADVCSRLDIDLVARAHQVVQDGYEFFASKKMVTIFSAPHYCGQFDNSAATMKVDENMVCTFVMYKPT
||.|||.. ... ||.|..||||.|..|| .  ..|..|..||| || .  | || ...||..   | ... .
fgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaa
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 84-298 5.7e-90 294.7 In-house 102-315 (317) alignment 
Range on Protein: 84-298
Range on HMM: 102-315/317.0
NFLFLGDYVDRGRQNIETICLMFCFKIKYPENFFMLRGNHECPAINRVYGFYEECNRRYkSTRLWSIFQDTFNWMPLCGLIGSRILCMHGGLSPHLQTLD
..||||||||||   || . |.|..|..||.. |.||||||  ..|. ||||.|...|| |..|. .|| .|| .||| .....|||||||.| .|  |.
kylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkry.saalyeafqlafnvlplcavvnkkilcmhGGiseelldlk

QLRQLPRPQDPPNPSIGIDLLWADPDQWVKGWQANTRGVSYVFGQDVVADVCSRLDIDLVARAHQVVQDGYEFFASKKMVTIFSAPHYCGQFDNSAATMK
|| .| || | |.  .  || |||||. |||..  .|| . |||.. | . . .||.||| ||||||.||||||| .|.||||||| ||||.|| || ..
qldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavls

VDENMVCTFVMYKPT
||....... ...| 
vdkklkisinvlrpe
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 25-297 1.1e-87 286.7 In-house 13-288 (290) alignment 
Range on Protein: 25-297
Range on HMM: 13-288/290.0
TTSVNEQELQTCCAVAKSVFASQASLLEVEPPIIVCGDIHGQYSDLLRIFDKNGFPPDINFLFLGDYVDRGRQNIETICLMFCFKIKYPENFFMLRGNHE
. . ..... .    .....    .||||| ||.. ||||||  .||| ||. |.||...||||||||||| . .|   |.||.||.|...  .||||||
ldafsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhe

CPAINRVYGFYEECNRRyKSTRLWSIFQDTFNWMPLCGLIGSRILCMHGGLSPHLQTLDQLRQLPRPQDPPNPS--IGIDLLWADPDQ-WVKGWQAN-TR
.  .||.|||.||  |. ...|||  .|| |. ..||  .| .|||||||.|..... . |. | .|. | .    . .|||||||..   .  . |  |
vrkvnrlygfkeelark.rgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqr

GVSYVFGQDVVADVCSRLDIDLVARAHQVVQDGYEFFASKKMVTIFSAPHYCGQFDNSAATMKVDENMVCTFVMYKP
..| |||.... |.. .| ..|. |||.| ..|..|   ||.||.||||.|.|.  |  | ..| | .  ..|. ||
aisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkp
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 29-300 1.6e-84 276.7 In-house 21-294 (307) alignment 
Range on Protein: 29-300
Range on HMM: 21-294/307.0
NEQELQTCCAVAKSVFASQASLLEVEPPIIVCGDIHGQYSDLLRIFDKNGFPPDINFLFLGDYVDRGRQNIETICLMFCFKIKYPENFFMLRGNHECPAI
  .|..     |...|.|. .|....|| .| ||.|||. ||. .|   | ||.  ..| |||||||  ..|.| |.|..|| ||||  .||||||   .
tkeefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarv

NRVYGFYEECNRRYK--STRLWSIFQDTFNWMPLCGLIGSRILCMHGGLSPHLQTLDQLRQLPRPQDPPNPSIGIDLLWADPDQWVKGWQANTRGVSYVF
|. |||||||          .|..||  || .|.  || ..|||||||||| |  ||.||. |.|   |   |  |.||||||  |  |.| .||  . |
nkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftf

GQDVVADVCSRLDIDLVARAHQVVQDGYEFFASKKMVTIFSAPHYCGQFDNSAATMKVDENMVCTFVMYKPTPK
| .|. ||| || ..|. ||||.. |||  .. .|..|||||| ||  . |. . .|||| .    | . |. .
gtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpese
subfamily_PPP6C_pd Subfamily PPP6C 27-301 9.6e-82 267.3 In-house 14-287 (290) alignment 
Range on Protein: 27-301
Range on HMM: 14-287/290.0
SVNEQELQTCCAVAKSVFASQASLLEVEPPIIVCGDIHGQYSDLLRIFDKNGFPPDINFLFLGDYVDRGRQNIETICLMFCFKIKYPENFFMLRGNHECP
 ..|..|.  |.. . ..  ....  |. |. ||||||||. ||. .| . |  || ...||||.||||   .||. .....|.|||..  .||||||. 
ylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesr

AINRVYGFYEECNRRYKSTRLWSIFQDTFNWMPLCGLIGSRILCMHGGLSPHLQTLDQLRQLPRPQDPPNPSIGIDLLWADPDQwVKGWQANTRGVSYVF
 | .|||||.|| ..| ..  |  . . |. .... .|  ..||.||||||...||||.| . | |. |.     ||.|.||.. |. |.  .||  |.|
qitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdped.vetwavsprgagylf

GQDVVADVCSRLDIDLVARAHQVVQDGYEFFASKKMVTIFSAPHYCGQFDNSAATMKVDENMVCTFVMYKPTPKS
|. |. . ..  ...|..||||.|..|....  .|.||..||| || .  | |. ......   .. ..|  |..
gskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfkavpde
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 50-302 9.1e-79 257.8 In-house 2-260 (263) alignment 
Range on Protein: 50-302
Range on HMM: 2-260/263.0
LLEVEPPIIVCGDIHGQYSDLLRIFDKNGFPPDINFLFLGDYVDRGRQNIETICLMFCFKIKYPENFFMLRGNHECPAINRVYGFYEECNRRYKSTRL--
|||.. || .||| |||| ||||||.  |     ..|||||||||| ...| | |.| .|.  | ....||||||  |||. |||. | ..|..   .  
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

--WSIFQDTFNWMPLCGLIGSRILCMHGGLSPHLQTLDQLRQLPRPQDPPN-PSIGIDLLWADPDQWVKGWQAN-TRGVSYVFGQDVVADVCSRLDIDLV
  .  |.. |..|||| ..  ||||||||.||||..||..| .| | .  .   .  |||||||..  ||.. |  | .| |||.  | |.| ||||||.
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidli

ARAHQVVQDGYEFFASKKMVTIFSAPHYCGQFDNSAATMKVDENMVCTFVMYKPTPKSL
 ||||||. || ||| ....|.||| .|  .. | || . |.. .  .||  ||    .
vrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkpedfev
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 28-292 1.6e-78 257.0 In-house 6-294 (302) alignment 
Range on Protein: 28-292
Range on HMM: 6-294/302.0
VNEQELQTCCAVAKSVFASQASLLEVEPPIIVCGDIHGQYSDLLRIFDKN------------GFPPDiNFLFLGDYVDRGRQNIETICLMFCFKIKYPEN
 ...|| . .    . .  . .| |. ||. . ||||||. ||.||. ..            .|  |  |.|||||||||.. || |||.|..|. ||.|
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssd.kfvflGdyvdrGsksieciclvfalkvlyptn

FFMLRGNHECPAINRVYGFYEECNRRYKST---RLWSIFQDTFNWMPLCGLIGSRILCMHGGLSPHLQTLDQLRQLPRPQD-PPNPSIGIDLLWADPDQW
. .||||||..|||  ||| || . |.  .   ..|  |...| .|||  |.|..|||.|||.||.|..|...... ||     . |.  |||.||| . 
yillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldv

---------VKGWQANTRGVSYVFGQDVVADVCSRLDIDLVARAHQVVQDGYEFFASKKMVTIFSAPHYCGQFDNSAATMKVDENMVCTF
          |  . . ||.|.|| .  | ||| ||...|. ||||..  |. ||| ||..|||||| |  . ||. |..||| |   . 
qllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsi
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 28-292 3.5e-78 255.8 In-house 7-295 (302) alignment 
Range on Protein: 28-292
Range on HMM: 7-295/302.0
VNEQELQTCCAVAKSVFASQASLLEVEPPIIVCGDIHGQYSDLLRIFDKN------------GFPPDiNFLFLGDYVDRGRQNIETICLMFCFKIKYPEN
 ...|| . .    . .  . .| |. ||. . ||||||. ||.||. ..            .|  |  |.|||||||||.. || |||.|..|. ||.|
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssd.kfvflGdyvdrGsksieciclvfalkvlyptn

FFMLRGNHECPAINRVYGFYEECNRRYKST---RLWSIFQDTFNWMPLCGLIGSRILCMHGGLSPHLQTLDQLRQLPRPQD-PPNPSIGIDLLWADPDQW
. .||||||..|||  ||| || . |.  .   ..|  |...| .|||  |.|..|||.|||.||.|..|...... ||     . |.  |||.||| . 
yillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldv

---------VKGWQANTRGVSYVFGQDVVADVCSRLDIDLVARAHQVVQDGYEFFASKKMVTIFSAPHYCGQFDNSAATMKVDENMVCTF
          |  . . ||.|.|| .  | ||| ||...|. ||||..  |. ||| ||..|||||| |  . ||. |..||| |   . 
qllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsi
subfamily_PPP5C_pd Subfamily PPP5C 38-295 1.1e-77 254.2 In-house 44-306 (322) alignment 
Range on Protein: 38-295
Range on HMM: 44-306/322.0
AVAKSVFASQASLLEVEP----PIIVCGDIHGQYSDLLRIFDKNGFPPD-INFLFLGDYVDRGRQNIETICLMFCFKIKYPENFFMLRGNHECPAINRVY
. ||... ...||.|..      . ||||||||. ||| ||..|| | .   .|| ||.||||   .|.| ....||. ||..||. |||||   .|..|
leakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnkly

GFYEECNRRYKsTRLWSIFQDTFNWMPLCGLIGSRILCMHGGLSP-HLQTLDQLRQLPRPQDPPNPSIGIDLLWADPDQWvKGWQANTRGVSYVFGQDVV
|| .|.. .|. ...  .|...|||.||. .| ...| .||||   .  |||.||.. | ..||. .. ..|||.||... .| .. .|||.  || || 
Gfegevkakyt.ekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqea.nGrspskrGvgvqfGpdvt

ADVCSRLDIDLVARAHQVVQDGYEFFASKKMVTIFSAPHYCGQFDNSAATMKV-DENMVCTFVMY
   .   ...|. |.|.| ..|||.    |..|.|||| || | .| .| ... ....  .|  .
kkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfktf
subfamily_PPG1_pd Subfamily PPG1 29-301 8.4e-74 241.5 In-house 15-299 (300) alignment 
Range on Protein: 29-301
Range on HMM: 15-299/300.0
NEQELQTCCAVAKSVFASQASLLEVEPPIIVCGDIHGQYSDLLRIFDKNGFPPDINFLFLGDYVDRGRQNIETICLMFCFKIKYPENFFMLRGNHECPAI
 |  ..  .   | .. ... . |.. |. | ||.|||. |.| ||.  |  || |.||||||||||   .||| |. ..|..||    .||||||   |
pevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrqi

NRVYGFYEECNRRY-KSTRLWSIFQDTFNWMPLCGLIGSRILCMHGGLSPHLQTLDQLRQLPRPQDPPNPSIGIDLLWADPD---------QWVKG--WQ
 .||||| || |.|   .|.|  . . |... |. .|   | |.||||||  ...||.. | | .. ||     ||||.||.            .|  ..
tqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqhfv

ANTRGVSYVFGQDVVADVCSRLDIDLVARAHQVVQDGYEFFASKKMVTIFSAPHYCGQFDNSAATMKVDENMVCTFVMYKPTPKS
   ||  | .|.|||       |.. . ||||....||. .  .|. |..||| || .  | |. ... |.    | .|. .|.|
vsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeeapes
subfamily_PPP3C_pd Subfamily PPP3C 28-289 8.3e-73 238.7 In-house 41-314 (452) alignment 
Range on Protein: 28-289
Range on HMM: 41-314/452.0
VNEQELQTCCAVAKSVFASQASLLEVEPPIIVCGDIHGQYSDLLRIFDKNGFPPDINFLFLGDYVDRGRQNIETICLMFCFKIKYPENFFMLRGNHECPA
..|.. .     | ... .. .||||| ||.|.||||||. |||..|. .| | ....||||||||||   ||..  ... ||.||...|.|||||||  
leeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrh

INRVYGFYEECNRRYkSTRLWSIFQDTFNWMPLCGLIGSRILCMHGGLSPHLQTLDQLRQLPRPQDPPNPSIGIDLLWADPDQWV------KGWQA-NTR
.   . | |||. .| | ...  . ..|. .||  |.  . ||.||||||....||....| | ..||.     ||||.|| .        . ..  ..|
lteyftfkeeckiky.seevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpnsvr

GVSYVFGQDVVADVCSRLDIDLVARAHQVVQDGYEFFAS------KKMVTIFSAPHYCGQFDNSAATMKVDENMV
| ||...   |..   . |.  . |||.. ..||. .          ..|.|||| |.. ..| || .|...| .
GcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennvm
PPP_2 57-249 9.3e-73 237.1 In-house 1-197 (198) alignment 
Range on Protein: 57-249
Range on HMM: 1-197/198.0
IIVCGDIHGQYSDLLRIFDKNGFPPDINFLFLGDYVDRGRQNIETICLMFCFKIKYPENFFMLRGNHECPAINRVYGFYEECNRRYKSTRLWSIFQDTFN
. ||||.|||..|||..|.. ...|. ..||||||||||....|...|....|..||.....||||||.  .|.||||..|. .......... .|..|.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

WMPLCGLIGSRILCMHGGLSPHLQTLDQLRQLPRPQDPPNPSIGIDLL----WADPDQWVKGWQANTRGVSYVFGQDVVADVCSRLDIDLVARAHQV
..||. || ...|..|||||.....||| ..  |... |. .  .|||    . ||..  .... ..||....||.||....... ...|. |||.|
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 85-298 3.4e-69 226.5 In-house 122-334 (339) alignment 
Range on Protein: 85-298
Range on HMM: 122-334/339.0
FLFLGDYVDRGRQNIETICLMFCFKIKYPENFFMLRGNHECPAINRVYGFYEECNRRYKsTRLWSIFQDTFNWMPLCGLIGSRILCMHGGLSPHLQTLDQ
.||||||||||   .| . |. ..|. ||.  ..||||||  ..|  |||| | | ||  ..|.  ||. || .|.| .|   |.|||||.| || ...|
ylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyryd.aqlyecfqnmfnvfpfcavinntimcmhggisehltsfnq

LRQLPRPQDPPNPSIGIDLLWADPDQWVKGWQANTRGVSYVFGQDVVADVCSRLDIDLVARAHQVVQDGYEFFASKKMVTIFSAPHYCGQFDNSAATMKV
.  . || . |.  .  || |||||   ||..  .|| |.|||   .  .  .||...| | ||||.||||||  ...||||||| |||| ||.|| . .
fsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfsi

DENMVCTFVMYKPT
|...  .  ...| 
dkklkisinvfrpe
PPP_4 57-249 1.2e-68 224.0 In-house 1-196 (197) alignment 
Range on Protein: 57-249
Range on HMM: 1-196/197.0
IIVCGDIHGQYSDLLRIFDKNG-FPP-DINFLFLGDYVDRGRQNIETICLMFCFKIKYPENFFMLRGNHECPAINRVYGFYEECNRRyKSTRLWSIFQDT
..|.||||||. ||| .. ||| .|. . ...||||||||| ...|...|....|..||.....||||||. ..|..|||..|. .. .. ......||.
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.hgkeilkklqdv

FNWMPLCGLIGSRILCMHGGLSPHLQTLDQLRQLPRPQDPP-NPSIGIDL-LWADPDQWVKGWQANTRGVSYVFGQDVVADVCSRLDIDLVARAHQV
|...||. || ...|..|||||..|..||..... |... | . .   || ||.|| .  .|.. ..||....||.||. ..... ...|. |.|..
fdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 57-250 1.3e-67 220.7 In-house 1-199 (199) alignment 
Range on Protein: 57-250
Range on HMM: 1-199/199.0
IIVCGDIHGQYSDLLRIFDKNG-FPP-DINFLFLGDYVDRGRQNIETICLMFCFKIKYPENFFMLRGNHECPAINRVYGFYEECNRRYKSTRLWSIFQDT
..||||.|||. ||| |. |.| .|. . ...|||||||||....|...|....|..||.....||||||. ..|..|||..|. ..|.. ....|..|.
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FNWMPLCGLIGSRILCMHGGLSPHLQTLDQLRQLPRPQDPP-NPSIGIDL-LWADPDQWVKG-WQANTRGVSYVFGQDVVADVCSRLDIDLVARAHQVV
|.|.||. || ...|..||||||.......|... |... | ..    || ||.|| . ..| .. ..||....||.||. ..... ...|. |.|...
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk
subfamily_PPPLV_pd Subfamily PPPLV 33-291 2.5e-51 167.7 In-house 2-282 (290) alignment 
Range on Protein: 33-291
Range on HMM: 2-282/290.0
LQTCCAVAKSVFASQASLLEVEPPIIVCGDIHGQYSDLLrIFDKNGF--PPD---INFLFLGDYVDRGRQNIETICLMFCFKIKYPENFFMLRGNHECPA
| . | ||  ..|..  |||.. |. | ||.||.| ||  .|.|  .   .|    ..||||||||||  ..| |. ..  |. ||  ...||||||  .
llslcdvavdilaaeerllelksptyvlgdlhgnyrdli.yfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnheles

INRVYGFYEECNRRYKS--TRLWSIFQDTFNWMPLCGLIGSRILCMHGGLSPHLQTL-------DQLRQLPRPQDPpNPsIGIDLLWADPDQW-------
.   . .. |.  ..       |  |...|...||   |  ...|.|.|.    .|        | | .|. . |   | . .|.||.||..        
vqesieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidg.ap.laldilwsdpaedrdlslrg

----VKGWQAN-TRGVSYVFGQDVVADVCSRLDIDLVARAHQVVQDGYEFFASKKMVTIFSAPHYCGQfDNSAATMKVDENMVCT
     .|.  |  || ..||..| .     | ... | |||.| . |...    ...|.||. .|||.  |.|| . ||.. . .
elvlneGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGs.sneaalilvdkkklri
Metallophos Calcineurin-like phosphoesterase 56-250 1.5e-44 145.7 Pfam-A 2-199 (200) alignment 
Range on Protein: 56-250
Range on HMM: 2-199/200.0
PIIVCGDIHGQYSDL----LRIFDKNGFPPDINFLFLGDYVDRGRQNIETICLM--FCFKIKYPENFFMLRGNHECPAINRVYGFYEECNR---------
.|.|.||.||.. ||    |....... ..  ..|||||.||||.  .||..|.  .. |...| ..|.||||||.. .| .|||..|...         
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------RYKSTRLWSIFQDTFNWMPLCGLIGSRILCMHGGLSPHLQTLDQLrqlprpqdppnpsigidllwadpdqwvkgwq
                         .. .. .  ....|...||. |.. .||..||.||..... |.                                
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

antrgVSYVFGQDVVADVCSRLDIDLVARAHQVV
      |. || |.. . . . ..||| |.|. .
.....gselfgpdalekllekygvdlvlrGHtHk
subfamily_PPP7C_pd Subfamily PPP7C 56-190 2.2e-40 131.6 In-house 65-201 (383) alignment 
Range on Protein: 56-190
Range on HMM: 65-201/383.0
PIIVCGDIHGQYSDLLRIFDKNGFPP-DINFLFLGDYVDRGRQNIETICLMFCFKIKYPENFFMLRGNHECPAINRVYGFYEECNRRY--KSTRLWSIFQ
 . ||||.||.  ||| |. |||.|  . ...| ||.||||.. .| ....... . ||..... |||||   .|  |||  | . .|  .....  ...
evtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlle

DTFNWMPLCGLIGSRILCMHGGLSPHlQTLDQLRQLPR
| | |.||. || ..|| .|||.| .   |. | .. |
dvfawlplatlidekilivhGGisdk.tdlelldkier
subfamily_PPP7C_pd Subfamily PPP7C 201-298 8e-20 63.9 In-house 238-335 (383) alignment 
Range on Protein: 201-298
Range on HMM: 238-335/383.0
IDLLWADPDQWvKGWQANT-RGVSYVFGQDVVADVCSRLDIDLVARAHQVVQDGYEFFASKKMVTIFSAPHYCGQFDNSAATMKVDENMVCTFVMYKPT
.|.||.|| .  .| ..|| ||    || || ... .. ...|. |.|.  ..||||   ||..|||||  |  .  |  | .|. ...   .| |. .
ldilwsdpkak.eGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqyqas
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 27-80 6.7e-14 44.8 In-house 8-61 (317) alignment 
Range on Protein: 27-80
Range on HMM: 8-61/317.0
SVNEQELQTCCAVAKSVFASQASLLEVEPPIIVCGDIHGQYSDLLRIFDKNGFP
 ..|.||   |  |. .| ..   ||.| |. ..||||||. ||| ..| ||.|
lfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwp
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 31-80 4.5e-10 32.1 In-house 14-63 (339) alignment 
Range on Protein: 31-80
Range on HMM: 14-63/339.0
QELQTCCAVAKSVFASQASLLEVEPPIIVCGDIHGQYSDLLRIFDKNGFP
 ||   |  |. .  |.  .|..| || | ||||||. ||| ..| ||.|
aelaelchrareliwsepiflkleapicvmgdihgqfddllamldmngwp
subfamily_YNL217W_pd Subfamily YNL217W 57-131 7.3e-09 28.5 In-house 12-82 (235) alignment 
Range on Protein: 57-131
Range on HMM: 12-82/235.0
IIVCGDIHGQYSDLLRIFD--KNGFPPDINFLFLGDYVDRGRQNIETICLMfcfkikYPENFFMLRGNHECPAINRV
..| ||.|| | .|....|  . |  ...  ...|| ...| ...|.. ..        ..   ..||||  .. ..
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllay