Gene let-92 in Caenorhabditis elegans

Synonym: CELE_F38H4.9, let-92

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP2C
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP122_AA protein Get Run
CeleP122_AA_14-304 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP2C_pd Subfamily PPP2C 17-305 2.4e-189 620.6 In-house 2-290 (290) alignment 
Range on Protein: 17-305
Range on HMM: 2-290/290.0
VDVDQWIEQLYECKPLSENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRY
 |.|..||.| |||.|.|..||.|||||||||.|| |||||.||||||||||||||||.||||.|||||||||||.||||||||||||||.|||.||.||
kdldklieklkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvry

KDRVTLLRGNHESRQITQVYGFYDECLRKYGNSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDDRG
|.|.|.||||||||||||||||||||||||||.|||||||||||..|||||||.|||||||||||||||||.||||||.||||||||.||||||||||||
keritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddrg

GWGISPRGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFDPAPRRG
||||||||||||||.||||.||..||||||.||||||||||||||||||||.|||||||||||||||..||||.|||||||||||||||
gwgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpaprrg
subfamily_PPP4C_pd Subfamily PPP4C 18-302 4.4e-148 485.2 In-house 2-286 (288) alignment 
Range on Protein: 18-302
Range on HMM: 2-286/288.0
DVDQWIEQLYECKPLSENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYK
|.|. ||.| .|. ..|..||.||.||.||| .| |||.| .|||||||.||||.||.||||.||. |.|||||.||.||||.|||||  ||..||.|| 
dldrqieklrrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvryp

DRVTLLRGNHESRQITQVYGFYDECLRKYGNSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDDRGG
||.||.||||||||||||||||||||||||..|||.| |..|| ..|.|..||.|||.||||||||.|||.||..|| ||||||||.||||||||.|  |
dritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedaeg

WGISPRGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFDPAP
|..||||||| ||.|..|.||..|...||.||||||||||..  ...|.||.||||||||||| ||..|||..|.. |  |. |.
wavsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaaa
subfamily_PPP6C_pd Subfamily PPP6C 18-299 7.6e-138 451.5 In-house 1-282 (290) alignment 
Range on Protein: 18-299
Range on HMM: 1-282/290.0
DVDQWIEQLYECKPLSENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYK
..|.|||.  .|| |.||..| ||.. ...| .| ||| |..|||||||.||||.||.|||. ||. |||.|.|.||.|||||||.||...|..||..| 
eldkwielakkckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakyp

DRVTLLRGNHESRQITQVYGFYDECLRKYGNSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDDRGG
||.|||||||||||||||||||||||.||||.|.|||.|..|| ....|..|.|..|.|||||| . |||.|| ..| ||.||.|..|||.||||.|   
dritllrgnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpedvet

WGISPRGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFD
| .||||||| ||. ... |.| | | ||.||||||.||...  | ..|||.||||||||||| |....|.|. . ..  |.
wavsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfk
subfamily_PPG1_pd Subfamily PPG1 20-303 8.5e-130 425.4 In-house 2-298 (300) alignment 
Range on Protein: 20-303
Range on HMM: 2-298/300.0
DQWIEQLYECKPLSENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDR
|. .|.|. .. | |  || |..| ||.| || ||.|.|.|||| |||||||.|..|.||.||. |||||||.|||||||.|||||.|||..||.||  |
decleklqkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsr

VTLLRGNHESRQITQVYGFYDECLRKY-GNSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPD-----
.||||||||||||||||||| |||||| |||.||||.|..|| . |.|..| .|.|.|||||||. ..| |. |||..|||.|| ..|||||||.     
itllrgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnp

-----DRGG--WGISPRGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFDPAPR
     || |  . .|.|||||..|.|. | | . | .  | |||||..|||.   |  . ||.|||||||||||.|...|| . ... |  .. ||.
tldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeeape
0045823 Metallo-dependent phosphatases 15-303 3.1e-122 401.5 In-house 26-326 (473) alignment 
Range on Protein: 15-303
Range on HMM: 26-326/473.0
LIVDVDQWIEQLYECKPLSENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKI
 ..|.|..||.|.... |.|.... |...||||| ||||..|.  ...|.||.|||..||..|... |  |.....|.||.||||..|.|.. || .|||
glldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalki

RYKDRVTLLRGNHESRQITQVYGFYDECLRKYgNSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDD
.| ..|.|||||||.|.....|||.||.|.|| . .....| ..... ||.|...|.|.. ||||||....|| ||...| .|.|..|...|||||||..
kypgnvfllrGNHElrllnglygfgdetleky.gedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdPwe

RGG--------WGISPRGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWSHDRN------VVTVFSAPNYCYRCGNQAAMVELDDDLkYSFLQFDP
  |        .| |||||||.||.|. | | . |||.|| |.|. |.|||.. .|..      ..|||||||||.|.|| ||....|.|| .|| ||||
ddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdp

APR
.| 
sph
PPP_3 32-299 4.2e-119 389.5 In-house 2-270 (271) alignment 
Range on Protein: 32-299
Range on HMM: 2-270/271.0
LSENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRGNHESRQ
||||..|.|..|.|||||||.|..|.. |||||||.|||..||.||||.||.||.|.|||.|||||||..|.|.. ||..|||.|...|.||||||||||
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

ITQVYGFYDECLRKYGNSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDL-LWSDPDDRGGWGISPRGAGYTFG
|..||||..|.|.|.|...|.|.....|...||.||.|......||||||||..||.|. |.| .|||.||...|| |.|||....|.. |.||||..||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

QDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFD
.|..|.|...| |.|| |||.|..|||.  ||..|||||||||||.|..|..|...|...|...| |..
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
PPP_1 33-287 2.1e-117 384.1 In-house 2-264 (264) alignment 
Range on Protein: 33-287
Range on HMM: 2-264/264.0
SENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRGNHESRQI
.|.....|..|.||.|.||.|..||. ..|||||.||||.||..|||.||.||.|||||.|||||||..|||.. ||..||..|.....||||||||||.
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

TQVYGFYDECLRKYGNSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDL--------LWSDPDDRGGWGISPRG
|.||||..|.|.|.......|..||.||..||.||.|..|...||||||..|.||.|| ..| .|||.||..|||        |..|.......  |.||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

AGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVEL
|||.||.|..|.|...|.|.|| |||....|||.. ..|.|||.|||.||.....|..|.|.|
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvkl
0049330 Metallo-dependent phosphatases 16-304 1.8e-114 374.8 In-house 14-302 (309) alignment 
Range on Protein: 16-304
Range on HMM: 14-302/309.0
IVDVDQWIEQLYECKPLSENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIR
. ..|..||.|. .| |||.....|..|||||| .|||..|.  ...|.||.|||..||..|... |  |.....|.||.||||..|.|.. || .||..
lslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkll

YKDRVTLLRGNHESRQITQVYGFYDECLRKYGnSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPD-D
| |.|.|||||||.|.....|||.||.||||| ...|..|.|.....||.|...|.|.| ||||||.. .||.||.|.| .|.|..|..||||||||. .
ypdnvfllrGNHElrllnglygfgdetlrkyg.aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpi

RGGWGISPRGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFDPAPRR
| |.. .|||.|..|| .. | | . |||.|| |.|..|..|| . .|....|||||||||.|.||..|..|.|.||..|||.|.|.|. 
regfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpll
PP2Ac_SM00156 33-301 6e-111 362.8 In-house 2-270 (271) alignment 
Range on Protein: 33-301
Range on HMM: 2-270/271.0
SENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRGNHESRQI
|...|..|.|..||||..|.|. ||  ||||.||.|||..||..|.. .|..|...|.|.|||||||..|.|...||..|||.| ..|.||||||||...
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

TQVYGFYDECLRKYgNSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDP-DDRGGWGISPRGAGYTFGQ
...|||..|. ||| ...... |...|...||.|||| .|.|.||||||.. .||.|| |.| .| |.||...||||||| ..  |. .| ||....||.
nkiygfeeevkrky.gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFge

DISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFDPA
|. . | ..| | || |||..|.|||.. .|...||.|||||||....|.||.......|| |. |....
davkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq
0053225 Metallo-dependent phosphatases 15-302 1.2e-110 362.4 In-house 5-292 (293) alignment 
Range on Protein: 15-302
Range on HMM: 5-292/293.0
LIVDVDQWIEQLYECKPLSENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKI
.....|..||.|. .| |||.....|...||||| ||||..|.. ...|.||.||...||..|... |  |.....|.||.||||..|.|.. || .||.
illlldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkl

RYKDRVTLLRGNHESRQITQVYGFYDECLRKYGNSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDD
.|.|.|.|||||||.......|||.||.|||||....|....|.....||.||..|.|.. ||||||....||.|| ..| ...|.||...||||||||.
lypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpdl

RGGWGISPRGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFDPAP
. ||..|.||.|..|| .. . | . |||.|| |.||.|..|| . .|...|||||||||..|.||..|...||..|...| .|.| .
wsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapvl
subfamily_PPP1C_pd Subfamily PPP1C 31-299 3.3e-107 350.9 In-house 9-277 (282) alignment 
Range on Protein: 31-299
Range on HMM: 9-277/282.0
PLSENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRGNHESR
 |.|.....|..||.||| ..| . |.. ||...||.|||..||. ||...|  |..||||.|||||||  |.||. ||...||.|.... |||||||| 
klkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesa

QITQVYGFYDECLRKYGNSnVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDD-RGGWGISPRGAGYTF
.|...||||||| |.|..  .|| ||| |.|.||.|||| .|.|.||||||... |..|| . |  |||..| .|||||||||. . ||. . ||  .||
sinriyGfydeckrrysik.lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsftf

GQDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFD
|.|. |.| ..| | || ||||.| .||..  .|..|||||||||| . .|..|....|..|. ||  . 
gkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilk
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 26-302 6.4e-98 320.4 In-house 18-295 (298) alignment 
Range on Protein: 26-302
Range on HMM: 18-295/298.0
LYECKPLSENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRG
   .| ..|..|..|.|.||.|..| . . ||  |..||||.|||. ||. ||. .|  ||.||||.||||||| ...|.. ||.. |..|.... ||||
kkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnffllrG

NHESRQITQVYGFYDECLRKYGNSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDD-RGGWGISPRG
|||  .| .|||||.|| |.| . .... | |.|. .|||||. |.|.|.|||||. . .||..|.| | .. ..|    ||||.||..   ||  . ||
nheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenavkgwaensrG

AGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFDPAP
....||.|  . . ..  . |. ||||.| .||..  ....||.||||.|| .  | ||....|..|. ||  . |. 
vsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpek
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 30-304 1.9e-89 292.9 In-house 22-297 (299) alignment 
Range on Protein: 30-304
Range on HMM: 22-297/299.0
KPLSENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRGNHES
| . |....|||. ||... ... . ||  |. ||||.|||. ||. .|.. |  ||.|.||.|||||||   .|...||.| ||.|..|  .|||||| 
ksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhec

RQITQVYGFYDECLRKYGNSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGYT
  | .|||||.|| ..|  . .|  | | |. .||| |. ..|.|.|||||| ..||| .| | | |. |      ||||.|||.   .|    ||  | 
painrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgvsyv

FGQDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFDPAPRR
||||. .   .  .. |..||||.| .||..  ....||.|||| || .  | ||....|..|  .|  . |.|..
fgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpks
subfamily_PPP3C_pd Subfamily PPP3C 21-290 7.4e-88 288.3 In-house 30-312 (452) alignment 
Range on Protein: 21-290
Range on HMM: 30-312/452.0
QWIEQLYECKPLSENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRV
   | . .   |.|...  . |.| ..|.||... ||  |.||.||.||||.||..||..||.  .|.|||.||||||||.|.|.|  | .||| |....
vlkehflkegrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstl

TLLRGNHESRQITQVYGFYDECLRKYGNsNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDDRGGWGI
 |||||||.| .|. . | .||  ||.. .|.. ... ||..||.||...| .|.|||||| | .|| |. ||| .|.|. ||.|||||||| .. |   
fllrGnhecrhlteyftfkeeckikyse.evydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeek

--------SPRGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWSHD------RNVVTVFSAPNYCYRCGNQAAMVELDDD
        |.||  | ..   . .| ..| |  | |||.   .||.  ..        ..|.||||||.    |.||.......
teekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyenn
subfamily_PPP5C_pd Subfamily PPP5C 19-301 1.4e-85 280.1 In-house 21-309 (322) alignment 
Range on Protein: 19-301
Range on HMM: 21-309/322.0
VDQWIEQLYECKPLSENQVKTLCEKAKEILEKEPNVQEVRCP----VTVCGDVHGQFHDLMELFKMGGK-SPDTNYLFMGDYVDRGYYSVETVSLLVCLK
|.. .|.. . | | .  . ..  .|||.|.|.| . |.. .    .|||||.||||.||...|.. |. |..  ||| ||.|||| .|||.. .|...|
vkellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfk

IRYKDRVTLLRGNHESRQITQVYGFYDECLRKYgNSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSI-DTLDHIRALDRIQEVPHEGPMCDLLWSDP
. | ... | |||||| .. ..||| .|.  || ...| . ||..|. .||. ... ... .||||  .   |||..| .|| .. |.|| ...||||||
llyPnhfflsrGnhesdnmnklyGfegevkaky.tekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdp

DDRGGWGISPRGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVEL-DDDLKYSFLQFDPA
... | . | || | .|| |... | ..|.|.|| |.|.. .|||. .|| ...||||||||| . ||..|...| .||||  | .|.  
qeanGrspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfktfeav
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 32-299 3.2e-85 279.0 In-house 8-281 (284) alignment 
Range on Protein: 32-299
Range on HMM: 8-281/284.0
LSENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKS------PDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRG
|.|...  || .|.|.. ||.  .|...||...||.|||| ||. |... |         ...|||.||||||| .|.| ..|| ..|... |.|.||||
lkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrg

NHESRQITQVYGFYDECLRKYGNsNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDDR-GGWGISPRG
||||| . . |||| || ..| . .... |   | ..||.|.|. .|.|.|||.|  .  |. . .|.|  ..|  | ..|| |.||. .  |.  ||||
nhesrpvnmqygfyleckkryse.alyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesprg

AGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFD
|| .||..  . |..   | |. ||||.||.||..  ||..||.|||| || .  | ||....|..|  ||  . 
agkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlk
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 29-301 3.2e-84 275.4 In-house 5-275 (280) alignment 
Range on Protein: 29-301
Range on HMM: 5-275/280.0
CkpLSENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRGNHE
|  . | ..... || |.||  .  . || .||.||||.|||. ||. ||.  .  ||.||||.||||||| . .| . ||.. |.|| ..  .||||||
c..ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhe

SRQITQVYGFYDECLRKYGnSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPD-DRGGWGISPRGAGY
  .| . |||.||. |.|   .... | .|.| .||.||| |.|.|.|||||. . .||... | |  . ..|    ||||.||. .  ||. ..||. .
visinrkygfkdevkrrys.lalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsv

TFGQDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFDPA
 ||...   . .   . || | ||.| .||..  |...|||||||.|.    |.||.. .|. |. ||  . ||
ifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpa
subfamily_PPZ_pd Subfamily PPZ 32-300 1.8e-82 270.3 In-house 25-293 (300) alignment 
Range on Protein: 32-300
Range on HMM: 25-293/300.0
LSENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRGNHESRQ
| ....  .| ||.|..  .|.. |.  .| . ||||||. ||. ||   |  | .||||.|||||||  |.||. ||.| ||.| . . |||||||  .
lknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecan

ITQVYGFYDECLRKyGNSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGYTFG
.|.|||||||| |.  | ..|| | | |. .||.|.| |.|||.|||||| ....| || . |  .||  | . ||||||| |    |    ||  | . 
vtrvygfydeckrr.cnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvsycyn

QDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFDP
.   . |    |. |. ||| .| .||..  ||..||||||||||    |  |.. . . |  ||  .||
kvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldp
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 34-303 4.7e-82 268.4 In-house 10-279 (281) alignment 
Range on Protein: 34-303
Range on HMM: 10-279/281.0
ENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRGNHESRQIT
.......  ... |. .| .. |.  |..| ||.|.||.|| .||.. |. |.. ..|.|||||||  |.|.. || .|||||.||. |||||||  .. 
keeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvn

QVYGFYDECLRKYGNsNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDDRG-GWGISPRGAGYTFGQD
..|||| ||  |||  ..|  |   |. .|..||.. .. |.|||||| . .||..|   .  . .. | . ||||.|||... .|  | ||...|||..
kiygfyvecvtkyGe.elwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfGkn

ISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFDPAPR
. .    . .. || ||||.|..||.    |...||||.||||    | ||.. .|..|. |.... ||. 
vvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpase
PPP_2 61-252 1.5e-80 262.6 In-house 1-197 (198) alignment 
Range on Protein: 61-252
Range on HMM: 1-197/198.0
VTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRGNHESRQITQVYGFYDECLRKYGNSNVWKYFTDLFD
||||||.|||..||..||| |..||...|||.|||||||..|.|.. ||..||..|...|.||||||||.....||||..|.|.|.|...|.|.....|.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

CFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDL-----LWSDPDDRGGWGISPRGAGYTFGQDISETFNHSNGLTLISRAHQL
..||.||.|......|||||..|..||.|.  .| .|.|.||...||     |..........  | ||||..||.|..|.. ..| |.|| |||..
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 31-300 9.5e-79 257.3 In-house 9-281 (287) alignment 
Range on Protein: 31-300
Range on HMM: 9-281/287.0
PLSENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRGNHESR
 .|.... .. ||..||||  | . ||. |.|..||.|||..||. .|.  |..|...|||.|||||||  |.| . || .|||.|  .| ||||||| .
afsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevk

QITQVYGFYDECLRKYGnSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQ--EVPHEGPMCDLLWSDPDDRgGWGIS---PRGA
.| ..|||..|  ||.. ....| | |.|. .|| | |. .|.|.|||.|| ...|| ..|| . .     .|| . ||||.||.     ..     |. 
kinklyGfkeelkrkrq.erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekd.aktfelnkirai

GYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFDP
   ||.   . . .  .. || |||... |||..  |...||||||| |. .  | .|.| ... |. || .. |
svvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkp
PPP_4 61-252 2.8e-76 248.9 In-house 1-196 (197) alignment 
Range on Protein: 61-252
Range on HMM: 1-196/197.0
VTVCGDVHGQFHDL-MELFKMGGKSP-DTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRGNHESRQITQVYGFYDECLRKyGNSNVWKYFTDL
|||.||.|||..|| ..|.|.||. . ...|.|.|||||||..|.|.. ||..||..|...|.||||||||......|||..|.|.|  .....|...|.
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.hgkeilkklqdv

FDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVP-HEGPMCDL-LWSDPD-DRGGWGISPRGAGYTFGQDISETFNHSNGLTLISRAHQL
||. ||.||.|......|||||.....||.|....| .|.| .|. ..|| |||||  .  |.  | ||||..||.|. |.| ..|.| || |.|.|
fdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 61-252 2e-75 246.2 In-house 1-198 (199) alignment 
Range on Protein: 61-252
Range on HMM: 1-198/199.0
VTVCGDVHGQFHDL-MELFKMG-GKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRGNHESRQITQVYGFYDECLRKYGNSNVWKYFTDL
||||||.|||..|| ..||| |  .|....|.|.|||||||..|.|.. ||..||..|...|.|||||||..|....|||..|.|.||......|...|.
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVP-HEGPMCDL-LWSDPD-DRGG-WGISPRGAGYTFGQDISETFNHSNGLTLISRAHQL
||. ||.||.|......||||||.|..........| .|.| ..| ..|| |||||  .  | .  | ||||..||.|. |.| . |.| || |.|.|
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshel
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 36-302 2.5e-74 243.2 In-house 10-276 (280) alignment 
Range on Protein: 36-302
Range on HMM: 10-276/280.0
QVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRGNHESRQITQV
.. ..    . |. .| |. |  .|. | ||.| |..|.  || . |. |. . .|.|||||||   .| . ||.||||||.||. |||||||.  . ..
eiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnki

YGFYDECLRKYGNSnVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDDRG-GWGISPRGAGYTFGQDIS
|||| ||  |||   .|  |   |. .|...|.  ...|.|||||| .  || || . |  |    | . ||||||| ..| ||  | ||  | ||. . 
ygfyvecqykygvg.lwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkgvv

ETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFDPAP
|   .|  . || ||||.| .||.    | ..|||| |||| .  | ||.| |. .|. || |. | |
eqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlippp
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 27-299 2.9e-74 243.0 In-house 18-293 (297) alignment 
Range on Protein: 27-299
Range on HMM: 18-293/297.0
YECKPLSENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRGN
  .| ..|..|  | . | ...... .. || .|. ||||.|||| ||. ||. ||  | .||||.||||||| .|.||. ||.. |...   . |||||
llskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgn

HESRQITQVYGFYDECLRKYGNSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSP---SIDTLDHIRALDRIQEVpHEGPMCDLLWSDPD-DRGGWGISP
||   . .|||||.|| ..|    ..  | |.|. .||| |.  .|.|.||||||      ||| .| ..| .|  .|. ..||||.||     |.    
hecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisglsgfmenq

RGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFD
||||  ||.|          | |. ||||.| .||..   |..||.|||| || .  | ||..  |. |. ||  . 
rgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilr
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 87-301 2.2e-73 240.2 In-house 101-315 (317) alignment 
Range on Protein: 87-301
Range on HMM: 101-315/317.0
TNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRGNHESRQITQVYGFYDECLRKYGNsNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTL
 .|||.||||||| .|.| |.||..||..| |.|.||||||||| . . |||| |. ..| . .... |   | ..||.|.|. .|.|.|||.| ..  |
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysa.alyeafqlafnvlplcavvnkkilcmhGGiseelldl

DHIRALDRIQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMV
. . .|.|  ..|  | ..|| |.||| .  |.  |.||||  ||..  . |..   | |. ||||.|..||..  ||..||.||||.|| .  | ||..
kqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavl

ELDDDLKYSFLQFDPA
..|..|| |.  . | 
svdkklkisinvlrpe
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 31-300 5.9e-72 235.1 In-house 15-288 (290) alignment 
Range on Protein: 31-300
Range on HMM: 15-288/290.0
PLSENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRGNHESR
 .|.... .. ||..||||  | . ||  |... ||.|||. .|.. |.  |. |. ..||.|||||||  |.|   || |.||||  .| ||||||| |
afsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevr

QITQVYGFYDECLRKYgNSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDR--IQEVPHEGPMCDLLWSDPDD--RGGWGI-SPRGA
.. ..|||..|  ||  .|..|| . |.|. ..| | |. .|.|.|||.|. |.. . ..|| .  ..   .|| . ||||.||.        .   |. 
kvnrlygfkeelarkr.gsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqrai

GYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFDP
   ||..  ... .  .| || |||..  ||.|.  |...||||||| |. .  |  |.... . |. |.  . |
svvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkp
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 34-300 1.4e-71 234.2 In-house 5-273 (284) alignment 
Range on Protein: 34-300
Range on HMM: 5-273/284.0
ENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRGNHESRQIT
 ..|.||  .| .|..|.| . ||  |. .|||.|||| ||. ||   |    .||||.||||||| . .||. ||.. |. . ... .||||||   | 
pedvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslin

QVYGFYDECLRKYGNSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPM-CDLLWSDPDD-RGGWGISPRGAGYTFGQ
..||||.|| |.| .  |.. |  .|  .||||||  .|.|.|||.|  .. . ..||. |  . |    .  |.||||| . . ||    ||  | || 
kiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgs

DISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFDP
|    .     . |. ||||.| .||..  .| .||.|||| || .  | ||.. .. .|  ||. . |
dalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrp
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 39-302 4.7e-64 209.5 In-house 27-293 (307) alignment 
Range on Protein: 39-302
Range on HMM: 27-293/307.0
TLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRGNHESRQITQVYGF
 .  .|. |.  |  . ..  |. | ||.|||| ||...| . |. |.| |.| |||||||  |.|.. ||.. || | . . |||||||  .. . |||
nviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygf

YDECLRKYG--NSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGYTFGQDISE
|.||.        ..|  |   |. .|..||.  .|.|.||||||..  || .|   .    |  | . |.||.|||     |  | ||.|.||| .. .
yeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgtnvid

TFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFDPAP
   .  |. || ||||....||     |...|.|||| ||    |  ... .|. |    . | |. 
dvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpes
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 55-300 1.8e-57 188.0 In-house 3-255 (263) alignment 
Range on Protein: 55-300
Range on HMM: 3-255/263.0
QEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRGNHESRQITQVYGFYDECLRKYGNSN----
 |...|. .||| |||. ||. .|.  | .  |.|||.||||||| .|.| . ||. ||.    .. ||||||| . | . |||. |  ...   .    
lelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyes

VWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPM-CDLLWSDPDDrGGWGISP---RGAGYTFGQDISETFNHSNGLTLI
|...| ..|  .|| |.|  .|.|.|||.|| . .|| |||.    |  .  |. |||||.||.     |. |   |     ||.   . . .   . ||
vynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpek.dakgfepnkiraisnvfgkkevddlckrldidli

SRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFDP
 ||||.|  || .  || ..|||||  |     | ||.| ..  |. ||.|. |
vrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkp
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 88-303 5.7e-57 186.3 In-house 121-336 (339) alignment 
Range on Protein: 88-303
Range on HMM: 121-336/339.0
NYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRGNHESRQITQVYGFYDECLRKYgNSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLD
 |||.||||||| .|.| | || .||. | ||. ||||||||| .   |||| |   .| ...... | ..|. ||. |...  |.|.|||.|  . ...
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyry.daqlyecfqnmfnvfpfcavinntimcmhggisehltsfn

HIRALDRIQEVPHEGPMCDLLWSDPDD-RGGWGISPRGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVE
..  . |  |.|  | . || |.|||    |.  | ||| . ||     .| .   | .. | ||.| .||..   | .||.||||||| .  | ||.. 
qfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfs

LDDDLKYSFLQFDPAPR
.|  || |   | |  |
idkklkisinvfrpesr
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 32-295 1.7e-56 184.6 In-house 6-294 (302) alignment 
Range on Protein: 32-295
Range on HMM: 6-294/302.0
LSENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSP-----------DTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRV
.|.... .|.|.  | |.|| .. |.  |||. ||.||||.||. ....  ..               ..|.|||||||. |.| ..|. .||. |. . 
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

TLLRGNHESRQITQVYGFYDECLRKYGNSN---VWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDR-IQEVPHEGPMCDLLWSDPDDRG
 |||||||.. |   ||| .|   ..|...   .|. | . |  .||.|||  .|.|.|||.|| ...|..|. ..| ..|| ..    |||..|| |  
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

GWGISPRGAGYTFG--QDISETFNHS--------NGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSF
.  . ..   |..   ...| .||..         .| || |||| . ||...  |....|.||||.|     |. |....| . | | 
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsi
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 31-295 2.5e-56 184.1 In-house 6-295 (302) alignment 
Range on Protein: 31-295
Range on HMM: 6-295/302.0
PLSENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSP-----------DTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDR
 .|.... .|.|.  | |.|| .. |.  |||. ||.||||.||. ....  ..               ..|.|||||||. |.| ..|. .||. |. .
eysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptn

VTLLRGNHESRQITQVYGFYDECLRKYGNSN---VWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDR-IQEVPHEGPMCDLLWSDPDDR
  |||||||.. |   ||| .|   ..|...   .|. | . |  .||.|||  .|.|.|||.|| ...|..|. ..| ..|| ..    |||..|| | 
yillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldv

GGWGISPRGAGYTFG--QDISETFNHS--------NGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSF
 .  . ..   |..   ...| .||..         .| || |||| . ||...  |....|.||||.|     |. |....| . | | 
qllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsi
subfamily_PPPLV_pd Subfamily PPPLV 38-288 1.7e-53 174.8 In-house 3-276 (290) alignment 
Range on Protein: 38-288
Range on HMM: 3-276/290.0
KTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLM----ELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRGNHESRQIT
 .||..| .|| .| .. |.. |. | ||.||...||.     |...| .   ...||.||||||| .||| .. |. ||. |  .| ||||||| . ..
lslcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvq

QVYGFYDECLRKYGNS--NVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRI----QEVPHEGPM-CDLLWSDPDDR-----------
. . .. |.  |.|.|  .||. |.. || .||.| .| ..|| |.|.  .| |  .| |.. |    ..  .  |.  |.|||||..            
esieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvl

--GGWGISPRGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRcGNQAAMVELD
  |    . || |. |..|  |.| . |.|  . |||.   .|..  ..  ..||||. .||    |.||.. .|
neGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGs.sneaalilvd
Metallophos Calcineurin-like phosphoesterase 60-252 1e-43 142.9 Pfam-A 2-198 (200) alignment 
Range on Protein: 60-252
Range on HMM: 2-198/200.0
PVTVCGDVHGQFHDL----MELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLL--VCLKIRYKDRVTLLRGNHESRQITQVYGFYDECL----------
...|.||.||...||    ..|.|...... ...||.||.|||| .| ||  ||   .||......| ||||||||......|||..|.|          
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

-----------------------RKYGNSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIraldriqevphegpmcdllwsdpddrggwgi
                       ..... ... .. . |.. || |||||.|.. ||.||.| .. | |                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

sprgAGYTFGQDISETFNHSNGLTLISRAHQL
    ... || |  | .   .|..|. |.|. 
....gselfgpdalekllekygvdlvlrGHtH
subfamily_PPP7C_pd Subfamily PPP7C 17-195 1.2e-38 125.9 In-house 18-202 (383) alignment 
Range on Protein: 17-195
Range on HMM: 18-202/383.0
VDVDQWIEQLYECKPLSENQVKTLCEKAKEILEKEPNVQEVRC----PVTVCGDVHGQFHDLME-LFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVC
 .|.. ||.. | | |  . | ..  .||..|.. ||...|       ||||||.||.. ||.  |.| |  |.. .|.| ||.||||  ||| . .|..
deveklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillilla

LKIRYKDRVTLLRGNHESRQITQVYGFYDECLRKY--GNSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDtLDHIRALDRI
| . |   | | |||||   .   |||  |   ||   .... . . |.|  .||..|.| .|. .|||.| . | |. .  ..| 
lllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdktd.lelldkiers
subfamily_PPP7C_pd Subfamily PPP7C 204-301 1.4e-21 69.6 In-house 237-335 (383) alignment 
Range on Protein: 204-301
Range on HMM: 237-335/383.0
MCDLLWSDPDD-RGGWGISPRGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFDPA
. |.|||||   .| .  . ||.|  || |... . .  .|.|. |.|.  .|||...||..|.|.||| ||     |. | | | .||.  ..|.  .
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqyqas
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 32-82 1.9e-13 43.3 In-house 9-59 (317) alignment 
Range on Protein: 32-82
Range on HMM: 9-59/317.0
LSENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGG
..|...  || .|.|.. |||   |...|||..||.||||.||. |... |
fkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnG
subfamily_YNL217W_pd Subfamily YNL217W 61-133 3.7e-10 32.7 In-house 12-80 (235) alignment 
Range on Protein: 61-133
Range on HMM: 12-80/235.0
VTVCGDVHGQFHDLMELFK--MGGKSPDTNYLFMGDYVDRGYYSVETVSLLvclkirYKDRVTLLRGNHESRQIT
. | ||||| . .|.||..  .||| ..   ...|| ...|  |||.||..       || |  ..||||   . 
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvll
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 36-82 6.3e-09 28.4 In-house 15-61 (339) alignment 
Range on Protein: 36-82
Range on HMM: 15-61/339.0
QVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGG
..  || .|.|..  || . .. .|. | ||.|||| ||. .. | |
elaelchrareliwsepiflkleapicvmgdihgqfddllamldmng