Gene let-92 in Caenorhabditis elegans

Synonym: CELE_F38H4.9, let-92

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP2C
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP122_AA protein Get Run
CeleP122_AA_14-304 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP2C_pd Subfamily PPP2C 17-305 2.4e-189 620.6 In-house 2-290 (290) alignment
Range on Protein: 17-305
Range on HMM: 2-290/290.0
VDVDQWIEQLYECKPLSENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRY
 |.|..||.| |||.|.|..||.|||||||||.|| |||||.||||||||||||||||.||||.|||||||||||.||||||||||||||.|||.||.||
kdldklieklkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvry

KDRVTLLRGNHESRQITQVYGFYDECLRKYGNSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDDRG
|.|.|.||||||||||||||||||||||||||.|||||||||||..|||||||.|||||||||||||||||.||||||.||||||||.||||||||||||
keritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddrg

GWGISPRGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFDPAPRRG
||||||||||||||.||||.||..||||||.||||||||||||||||||||.|||||||||||||||..||||.|||||||||||||||
gwgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpaprrg

subfamily_PPP4C_pd Subfamily PPP4C 18-302 4.4e-148 485.2 In-house 2-286 (288) alignment
Range on Protein: 18-302
Range on HMM: 2-286/288.0
DVDQWIEQLYECKPLSENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYK
|.|. ||.| .|. ..|..||.||.||.||| .| |||.| .|||||||.||||.||.||||.||. |.|||||.||.||||.|||||  ||..||.|| 
dldrqieklrrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvryp

DRVTLLRGNHESRQITQVYGFYDECLRKYGNSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDDRGG
||.||.||||||||||||||||||||||||..|||.| |..|| ..|.|..||.|||.||||||||.|||.||..|| ||||||||.||||||||.|  |
dritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedaeg

WGISPRGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFDPAP
|..||||||| ||.|..|.||..|...||.||||||||||..  ...|.||.||||||||||| ||..|||..|.. |  |. |.
wavsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaaa

subfamily_PPP6C_pd Subfamily PPP6C 18-299 7.6e-138 451.5 In-house 1-282 (290) alignment
Range on Protein: 18-299
Range on HMM: 1-282/290.0
DVDQWIEQLYECKPLSENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYK
..|.|||.  .|| |.||..| ||.. ...| .| ||| |..|||||||.||||.||.|||. ||. |||.|.|.||.|||||||.||...|..||..| 
eldkwielakkckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakyp

DRVTLLRGNHESRQITQVYGFYDECLRKYGNSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDDRGG
||.|||||||||||||||||||||||.||||.|.|||.|..|| ....|..|.|..|.|||||| . |||.|| ..| ||.||.|..|||.||||.|   
dritllrgnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpedvet

WGISPRGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFD
| .||||||| ||. ... |.| | | ||.||||||.||...  | ..|||.||||||||||| |....|.|. . ..  |.
wavsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfk

subfamily_PPG1_pd Subfamily PPG1 20-303 8.5e-130 425.4 In-house 2-298 (300) alignment
Range on Protein: 20-303
Range on HMM: 2-298/300.0
DQWIEQLYECKPLSENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDR
|. .|.|. .. | |  || |..| ||.| || ||.|.|.|||| |||||||.|..|.||.||. |||||||.|||||||.|||||.|||..||.||  |
decleklqkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsr

VTLLRGNHESRQITQVYGFYDECLRKY-GNSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPD-----
.||||||||||||||||||| |||||| |||.||||.|..|| . |.|..| .|.|.|||||||. ..| |. |||..|||.|| ..|||||||.     
itllrgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnp

-----DRGG--WGISPRGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFDPAPR
     || |  . .|.|||||..|.|. | | . | .  | |||||..|||.   |  . ||.|||||||||||.|...|| . ... |  .. ||.
tldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeeape

0045823 Metallo-dependent phosphatases 15-303 3.1e-122 401.5 In-house 26-326 (473) alignment
Range on Protein: 15-303
Range on HMM: 26-326/473.0
LIVDVDQWIEQLYECKPLSENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKI
 ..|.|..||.|.... |.|.... |...||||| ||||..|.  ...|.||.|||..||..|... |  |.....|.||.||||..|.|.. || .|||
glldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalki

RYKDRVTLLRGNHESRQITQVYGFYDECLRKYgNSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDD
.| ..|.|||||||.|.....|||.||.|.|| . .....| ..... ||.|...|.|.. ||||||....|| ||...| .|.|..|...|||||||..
kypgnvfllrGNHElrllnglygfgdetleky.gedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdPwe

RGG--------WGISPRGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWSHDRN------VVTVFSAPNYCYRCGNQAAMVELDDDLkYSFLQFDP
  |        .| |||||||.||.|. | | . |||.|| |.|. |.|||.. .|..      ..|||||||||.|.|| ||....|.|| .|| ||||
ddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdp

APR
.| 
sph

PPP_3 32-299 4.2e-119 389.5 In-house 2-270 (271) alignment
Range on Protein: 32-299
Range on HMM: 2-270/271.0
LSENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRGNHESRQ
||||..|.|..|.|||||||.|..|.. |||||||.|||..||.||||.||.||.|.|||.|||||||..|.|.. ||..|||.|...|.||||||||||
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

ITQVYGFYDECLRKYGNSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDL-LWSDPDDRGGWGISPRGAGYTFG
|..||||..|.|.|.|...|.|.....|...||.||.|......||||||||..||.|. |.| .|||.||...|| |.|||....|.. |.||||..||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

QDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFD
.|..|.|...| |.|| |||.|..|||.  ||..|||||||||||.|..|..|...|...|...| |..
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle

PPP_1 33-287 2.1e-117 384.1 In-house 2-264 (264) alignment
Range on Protein: 33-287
Range on HMM: 2-264/264.0
SENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRGNHESRQI
.|.....|..|.||.|.||.|..||. ..|||||.||||.||..|||.||.||.|||||.|||||||..|||.. ||..||..|.....||||||||||.
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

TQVYGFYDECLRKYGNSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDL--------LWSDPDDRGGWGISPRG
|.||||..|.|.|.......|..||.||..||.||.|..|...||||||..|.||.|| ..| .|||.||..|||        |..|.......  |.||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

AGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVEL
|||.||.|..|.|...|.|.|| |||....|||.. ..|.|||.|||.||.....|..|.|.|
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvkl

0049330 Metallo-dependent phosphatases 16-304 1.8e-114 374.8 In-house 14-302 (309) alignment
Range on Protein: 16-304
Range on HMM: 14-302/309.0
IVDVDQWIEQLYECKPLSENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIR
. ..|..||.|. .| |||.....|..|||||| .|||..|.  ...|.||.|||..||..|... |  |.....|.||.||||..|.|.. || .||..
lslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkll

YKDRVTLLRGNHESRQITQVYGFYDECLRKYGnSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPD-D
| |.|.|||||||.|.....|||.||.||||| ...|..|.|.....||.|...|.|.| ||||||.. .||.||.|.| .|.|..|..||||||||. .
ypdnvfllrGNHElrllnglygfgdetlrkyg.aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpi

RGGWGISPRGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFDPAPRR
| |.. .|||.|..|| .. | | . |||.|| |.|..|..|| . .|....|||||||||.|.||..|..|.|.||..|||.|.|.|. 
regfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpll

PP2Ac_SM00156 33-301 6e-111 362.8 In-house 2-270 (271) alignment
Range on Protein: 33-301
Range on HMM: 2-270/271.0
SENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRGNHESRQI
|...|..|.|..||||..|.|. ||  ||||.||.|||..||..|.. .|..|...|.|.|||||||..|.|...||..|||.| ..|.||||||||...
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

TQVYGFYDECLRKYgNSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDP-DDRGGWGISPRGAGYTFGQ
...|||..|. ||| ...... |...|...||.|||| .|.|.||||||.. .||.|| |.| .| |.||...||||||| ..  |. .| ||....||.
nkiygfeeevkrky.gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFge

DISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFDPA
|. . | ..| | || |||..|.|||.. .|...||.|||||||....|.||.......|| |. |....
davkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq

0053225 Metallo-dependent phosphatases 15-302 1.2e-110 362.4 In-house 5-292 (293) alignment
Range on Protein: 15-302
Range on HMM: 5-292/293.0
LIVDVDQWIEQLYECKPLSENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKI
.....|..||.|. .| |||.....|...||||| ||||..|.. ...|.||.||...||..|... |  |.....|.||.||||..|.|.. || .||.
illlldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkl

RYKDRVTLLRGNHESRQITQVYGFYDECLRKYGNSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDD
.|.|.|.|||||||.......|||.||.|||||....|....|.....||.||..|.|.. ||||||....||.|| ..| ...|.||...||||||||.
lypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpdl

RGGWGISPRGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFDPAP
. ||..|.||.|..|| .. . | . |||.|| |.||.|..|| . .|...|||||||||..|.||..|...||..|...| .|.| .
wsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapvl

subfamily_PPP1C_pd Subfamily PPP1C 31-299 3.3e-107 350.9 In-house 9-277 (282) alignment
Range on Protein: 31-299
Range on HMM: 9-277/282.0
PLSENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRGNHESR
 |.|.....|..||.||| ..| . |.. ||...||.|||..||. ||...|  |..||||.|||||||  |.||. ||...||.|.... |||||||| 
klkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesa

QITQVYGFYDECLRKYGNSnVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDD-RGGWGISPRGAGYTF
.|...||||||| |.|..  .|| ||| |.|.||.|||| .|.|.||||||... |..|| . |  |||..| .|||||||||. . ||. . ||  .||
sinriyGfydeckrrysik.lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsftf

GQDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFD
|.|. |.| ..| | || ||||.| .||..  .|..|||||||||| . .|..|....|..|. ||  . 
gkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilk

subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 26-302 6.4e-98 320.4 In-house 18-295 (298) alignment
Range on Protein: 26-302
Range on HMM: 18-295/298.0
LYECKPLSENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRG
   .| ..|..|..|.|.||.|..| . . ||  |..||||.|||. ||. ||. .|  ||.||||.||||||| ...|.. ||.. |..|.... ||||
kkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnffllrG

NHESRQITQVYGFYDECLRKYGNSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDD-RGGWGISPRG
|||  .| .|||||.|| |.| . .... | |.|. .|||||. |.|.|.|||||. . .||..|.| | .. ..|    ||||.||..   ||  . ||
nheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenavkgwaensrG

AGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFDPAP
....||.|  . . ..  . |. ||||.| .||..  ....||.||||.|| .  | ||....|..|. ||  . |. 
vsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpek

subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 30-304 1.9e-89 292.9 In-house 22-297 (299) alignment
Range on Protein: 30-304
Range on HMM: 22-297/299.0
KPLSENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRGNHES
| . |....|||. ||... ... . ||  |. ||||.|||. ||. .|.. |  ||.|.||.|||||||   .|...||.| ||.|..|  .|||||| 
ksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhec

RQITQVYGFYDECLRKYGNSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGYT
  | .|||||.|| ..|  . .|  | | |. .||| |. ..|.|.|||||| ..||| .| | | |. |      ||||.|||.   .|    ||  | 
painrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgvsyv

FGQDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFDPAPRR
||||. .   .  .. |..||||.| .||..  ....||.|||| || .  | ||....|..|  .|  . |.|..
fgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpks

subfamily_PPP3C_pd Subfamily PPP3C 21-290 7.4e-88 288.3 In-house 30-312 (452) alignment
Range on Protein: 21-290
Range on HMM: 30-312/452.0
QWIEQLYECKPLSENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRV
   | . .   |.|...  . |.| ..|.||... ||  |.||.||.||||.||..||..||.  .|.|||.||||||||.|.|.|  | .||| |....
vlkehflkegrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstl

TLLRGNHESRQITQVYGFYDECLRKYGNsNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDDRGGWGI
 |||||||.| .|. . | .||  ||.. .|.. ... ||..||.||...| .|.|||||| | .|| |. ||| .|.|. ||.|||||||| .. |   
fllrGnhecrhlteyftfkeeckikyse.evydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeek

--------SPRGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWSHD------RNVVTVFSAPNYCYRCGNQAAMVELDDD
        |.||  | ..   . .| ..| |  | |||.   .||.  ..        ..|.||||||.    |.||.......
teekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyenn

subfamily_PPP5C_pd Subfamily PPP5C 19-301 1.4e-85 280.1 In-house 21-309 (322) alignment
Range on Protein: 19-301
Range on HMM: 21-309/322.0
VDQWIEQLYECKPLSENQVKTLCEKAKEILEKEPNVQEVRCP----VTVCGDVHGQFHDLMELFKMGGK-SPDTNYLFMGDYVDRGYYSVETVSLLVCLK
|.. .|.. . | | .  . ..  .|||.|.|.| . |.. .    .|||||.||||.||...|.. |. |..  ||| ||.|||| .|||.. .|...|
vkellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfk

IRYKDRVTLLRGNHESRQITQVYGFYDECLRKYgNSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSI-DTLDHIRALDRIQEVPHEGPMCDLLWSDP
. | ... | |||||| .. ..||| .|.  || ...| . ||..|. .||. ... ... .||||  .   |||..| .|| .. |.|| ...||||||
llyPnhfflsrGnhesdnmnklyGfegevkaky.tekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdp

DDRGGWGISPRGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVEL-DDDLKYSFLQFDPA
... | . | || | .|| |... | ..|.|.|| |.|.. .|||. .|| ...||||||||| . ||..|...| .||||  | .|.  
qeanGrspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfktfeav

subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 32-299 3.2e-85 279.0 In-house 8-281 (284) alignment
Range on Protein: 32-299
Range on HMM: 8-281/284.0
LSENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKS------PDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRG
|.|...  || .|.|.. ||.  .|...||...||.|||| ||. |... |         ...|||.||||||| .|.| ..|| ..|... |.|.||||
lkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrg

NHESRQITQVYGFYDECLRKYGNsNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDDR-GGWGISPRG
||||| . . |||| || ..| . .... |   | ..||.|.|. .|.|.|||.|  .  |. . .|.|  ..|  | ..|| |.||. .  |.  ||||
nhesrpvnmqygfyleckkryse.alyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesprg

AGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFD
|| .||..  . |..   | |. ||||.||.||..  ||..||.|||| || .  | ||....|..|  ||  . 
agkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlk

subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 29-301 3.2e-84 275.4 In-house 5-275 (280) alignment
Range on Protein: 29-301
Range on HMM: 5-275/280.0
CkpLSENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRGNHE
|  . | ..... || |.||  .  . || .||.||||.|||. ||. ||.  .  ||.||||.||||||| . .| . ||.. |.|| ..  .||||||
c..ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhe

SRQITQVYGFYDECLRKYGnSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPD-DRGGWGISPRGAGY
  .| . |||.||. |.|   .... | .|.| .||.||| |.|.|.|||||. . .||... | |  . ..|    ||||.||. .  ||. ..||. .
visinrkygfkdevkrrys.lalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsv

TFGQDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFDPA
 ||...   . .   . || | ||.| .||..  |...|||||||.|.    |.||.. .|. |. ||  . ||
ifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpa

subfamily_PPZ_pd Subfamily PPZ 32-300 1.8e-82 270.3 In-house 25-293 (300) alignment
Range on Protein: 32-300
Range on HMM: 25-293/300.0
LSENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRGNHESRQ
| ....  .| ||.|..  .|.. |.  .| . ||||||. ||. ||   |  | .||||.|||||||  |.||. ||.| ||.| . . |||||||  .
lknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecan

ITQVYGFYDECLRKyGNSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGYTFG
.|.|||||||| |.  | ..|| | | |. .||.|.| |.|||.|||||| ....| || . |  .||  | . ||||||| |    |    ||  | . 
vtrvygfydeckrr.cnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvsycyn

QDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFDP
.   . |    |. |. ||| .| .||..  ||..||||||||||    |  |.. . . |  ||  .||
kvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldp

subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 34-303 4.7e-82 268.4 In-house 10-279 (281) alignment
Range on Protein: 34-303
Range on HMM: 10-279/281.0
ENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRGNHESRQIT
.......  ... |. .| .. |.  |..| ||.|.||.|| .||.. |. |.. ..|.|||||||  |.|.. || .|||||.||. |||||||  .. 
keeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvn

QVYGFYDECLRKYGNsNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDDRG-GWGISPRGAGYTFGQD
..|||| ||  |||  ..|  |   |. .|..||.. .. |.|||||| . .||..|   .  . .. | . ||||.|||... .|  | ||...|||..
kiygfyvecvtkyGe.elwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfGkn

ISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFDPAPR
. .    . .. || ||||.|..||.    |...||||.||||    | ||.. .|..|. |.... ||. 
vvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpase

PPP_2 61-252 1.5e-80 262.6 In-house 1-197 (198) alignment
Range on Protein: 61-252
Range on HMM: 1-197/198.0
VTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRGNHESRQITQVYGFYDECLRKYGNSNVWKYFTDLFD
||||||.|||..||..||| |..||...|||.|||||||..|.|.. ||..||..|...|.||||||||.....||||..|.|.|.|...|.|.....|.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

CFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDL-----LWSDPDDRGGWGISPRGAGYTFGQDISETFNHSNGLTLISRAHQL
..||.||.|......|||||..|..||.|.  .| .|.|.||...||     |..........  | ||||..||.|..|.. ..| |.|| |||..
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev

subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 31-300 9.5e-79 257.3 In-house 9-281 (287) alignment
Range on Protein: 31-300
Range on HMM: 9-281/287.0
PLSENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRGNHESR
 .|.... .. ||..||||  | . ||. |.|..||.|||..||. .|.  |..|...|||.|||||||  |.| . || .|||.|  .| ||||||| .
afsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevk

QITQVYGFYDECLRKYGnSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQ--EVPHEGPMCDLLWSDPDDRgGWGIS---PRGA
.| ..|||..|  ||.. ....| | |.|. .|| | |. .|.|.|||.|| ...|| ..|| . .     .|| . ||||.||.     ..     |. 
kinklyGfkeelkrkrq.erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekd.aktfelnkirai

GYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFDP
   ||.   . . .  .. || |||... |||..  |...||||||| |. .  | .|.| ... |. || .. |
svvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkp

PPP_4 61-252 2.8e-76 248.9 In-house 1-196 (197) alignment
Range on Protein: 61-252
Range on HMM: 1-196/197.0
VTVCGDVHGQFHDL-MELFKMGGKSP-DTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRGNHESRQITQVYGFYDECLRKyGNSNVWKYFTDL
|||.||.|||..|| ..|.|.||. . ...|.|.|||||||..|.|.. ||..||..|...|.||||||||......|||..|.|.|  .....|...|.
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.hgkeilkklqdv

FDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVP-HEGPMCDL-LWSDPD-DRGGWGISPRGAGYTFGQDISETFNHSNGLTLISRAHQL
||. ||.||.|......|||||.....||.|....| .|.| .|. ..|| |||||  .  |.  | ||||..||.|. |.| ..|.| || |.|.|
fdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel

PPP_5_Dcr2 61-252 2e-75 246.2 In-house 1-198 (199) alignment
Range on Protein: 61-252
Range on HMM: 1-198/199.0
VTVCGDVHGQFHDL-MELFKMG-GKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRGNHESRQITQVYGFYDECLRKYGNSNVWKYFTDL
||||||.|||..|| ..||| |  .|....|.|.|||||||..|.|.. ||..||..|...|.|||||||..|....|||..|.|.||......|...|.
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVP-HEGPMCDL-LWSDPD-DRGG-WGISPRGAGYTFGQDISETFNHSNGLTLISRAHQL
||. ||.||.|......||||||.|..........| .|.| ..| ..|| |||||  .  | .  | ||||..||.|. |.| . |.| || |.|.|
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshel

subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 36-302 2.5e-74 243.2 In-house 10-276 (280) alignment
Range on Protein: 36-302
Range on HMM: 10-276/280.0
QVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRGNHESRQITQV
.. ..    . |. .| |. |  .|. | ||.| |..|.  || . |. |. . .|.|||||||   .| . ||.||||||.||. |||||||.  . ..
eiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnki

YGFYDECLRKYGNSnVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDDRG-GWGISPRGAGYTFGQDIS
|||| ||  |||   .|  |   |. .|...|.  ...|.|||||| .  || || . |  |    | . ||||||| ..| ||  | ||  | ||. . 
ygfyvecqykygvg.lwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkgvv

ETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFDPAP
|   .|  . || ||||.| .||.    | ..|||| |||| .  | ||.| |. .|. || |. | |
eqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlippp

subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 27-299 2.9e-74 243.0 In-house 18-293 (297) alignment
Range on Protein: 27-299
Range on HMM: 18-293/297.0
YECKPLSENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRGN
  .| ..|..|  | . | ...... .. || .|. ||||.|||| ||. ||. ||  | .||||.||||||| .|.||. ||.. |...   . |||||
llskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgn

HESRQITQVYGFYDECLRKYGNSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSP---SIDTLDHIRALDRIQEVpHEGPMCDLLWSDPD-DRGGWGISP
||   . .|||||.|| ..|    ..  | |.|. .||| |.  .|.|.||||||      ||| .| ..| .|  .|. ..||||.||     |.    
hecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisglsgfmenq

RGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFD
||||  ||.|          | |. ||||.| .||..   |..||.|||| || .  | ||..  |. |. ||  . 
rgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilr

subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 87-301 2.2e-73 240.2 In-house 101-315 (317) alignment
Range on Protein: 87-301
Range on HMM: 101-315/317.0
TNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRGNHESRQITQVYGFYDECLRKYGNsNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTL
 .|||.||||||| .|.| |.||..||..| |.|.||||||||| . . |||| |. ..| . .... |   | ..||.|.|. .|.|.|||.| ..  |
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysa.alyeafqlafnvlplcavvnkkilcmhGGiseelldl

DHIRALDRIQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMV
. . .|.|  ..|  | ..|| |.||| .  |.  |.||||  ||..  . |..   | |. ||||.|..||..  ||..||.||||.|| .  | ||..
kqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavl

ELDDDLKYSFLQFDPA
..|..|| |.  . | 
svdkklkisinvlrpe

subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 31-300 5.9e-72 235.1 In-house 15-288 (290) alignment
Range on Protein: 31-300
Range on HMM: 15-288/290.0
PLSENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRGNHESR
 .|.... .. ||..||||  | . ||  |... ||.|||. .|.. |.  |. |. ..||.|||||||  |.|   || |.||||  .| ||||||| |
afsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevr

QITQVYGFYDECLRKYgNSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDR--IQEVPHEGPMCDLLWSDPDD--RGGWGI-SPRGA
.. ..|||..|  ||  .|..|| . |.|. ..| | |. .|.|.|||.|. |.. . ..|| .  ..   .|| . ||||.||.        .   |. 
kvnrlygfkeelarkr.gsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqrai

GYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFDP
   ||..  ... .  .| || |||..  ||.|.  |...||||||| |. .  |  |.... . |. |.  . |
svvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkp

subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 34-300 1.4e-71 234.2 In-house 5-273 (284) alignment
Range on Protein: 34-300
Range on HMM: 5-273/284.0
ENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRGNHESRQIT
 ..|.||  .| .|..|.| . ||  |. .|||.|||| ||. ||   |    .||||.||||||| . .||. ||.. |. . ... .||||||   | 
pedvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslin

QVYGFYDECLRKYGNSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPM-CDLLWSDPDD-RGGWGISPRGAGYTFGQ
..||||.|| |.| .  |.. |  .|  .||||||  .|.|.|||.|  .. . ..||. |  . |    .  |.||||| . . ||    ||  | || 
kiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgs

DISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFDP
|    .     . |. ||||.| .||..  .| .||.|||| || .  | ||.. .. .|  ||. . |
dalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrp

subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 39-302 4.7e-64 209.5 In-house 27-293 (307) alignment
Range on Protein: 39-302
Range on HMM: 27-293/307.0
TLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRGNHESRQITQVYGF
 .  .|. |.  |  . ..  |. | ||.|||| ||...| . |. |.| |.| |||||||  |.|.. ||.. || | . . |||||||  .. . |||
nviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygf

YDECLRKYG--NSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGYTFGQDISE
|.||.        ..|  |   |. .|..||.  .|.|.||||||..  || .|   .    |  | . |.||.|||     |  | ||.|.||| .. .
yeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgtnvid

TFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFDPAP
   .  |. || ||||....||     |...|.|||| ||    |  ... .|. |    . | |. 
dvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpes

subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 55-300 1.8e-57 188.0 In-house 3-255 (263) alignment
Range on Protein: 55-300
Range on HMM: 3-255/263.0
QEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRGNHESRQITQVYGFYDECLRKYGNSN----
 |...|. .||| |||. ||. .|.  | .  |.|||.||||||| .|.| . ||. ||.    .. ||||||| . | . |||. |  ...   .    
lelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyes

VWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPM-CDLLWSDPDDrGGWGISP---RGAGYTFGQDISETFNHSNGLTLI
|...| ..|  .|| |.|  .|.|.|||.|| . .|| |||.    |  .  |. |||||.||.     |. |   |     ||.   . . .   . ||
vynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpek.dakgfepnkiraisnvfgkkevddlckrldidli

SRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFDP
 ||||.|  || .  || ..|||||  |     | ||.| ..  |. ||.|. |
vrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkp

subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 88-303 5.7e-57 186.3 In-house 121-336 (339) alignment
Range on Protein: 88-303
Range on HMM: 121-336/339.0
NYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRGNHESRQITQVYGFYDECLRKYgNSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLD
 |||.||||||| .|.| | || .||. | ||. ||||||||| .   |||| |   .| ...... | ..|. ||. |...  |.|.|||.|  . ...
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyry.daqlyecfqnmfnvfpfcavinntimcmhggisehltsfn

HIRALDRIQEVPHEGPMCDLLWSDPDD-RGGWGISPRGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVE
..  . |  |.|  | . || |.|||    |.  | ||| . ||     .| .   | .. | ||.| .||..   | .||.||||||| .  | ||.. 
qfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfs

LDDDLKYSFLQFDPAPR
.|  || |   | |  |
idkklkisinvfrpesr

subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 32-295 1.7e-56 184.6 In-house 6-294 (302) alignment
Range on Protein: 32-295
Range on HMM: 6-294/302.0
LSENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSP-----------DTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRV
.|.... .|.|.  | |.|| .. |.  |||. ||.||||.||. ....  ..               ..|.|||||||. |.| ..|. .||. |. . 
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

TLLRGNHESRQITQVYGFYDECLRKYGNSN---VWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDR-IQEVPHEGPMCDLLWSDPDDRG
 |||||||.. |   ||| .|   ..|...   .|. | . |  .||.|||  .|.|.|||.|| ...|..|. ..| ..|| ..    |||..|| |  
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

GWGISPRGAGYTFG--QDISETFNHS--------NGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSF
.  . ..   |..   ...| .||..         .| || |||| . ||...  |....|.||||.|     |. |....| . | | 
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsi

subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 31-295 2.5e-56 184.1 In-house 6-295 (302) alignment
Range on Protein: 31-295
Range on HMM: 6-295/302.0
PLSENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSP-----------DTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDR
 .|.... .|.|.  | |.|| .. |.  |||. ||.||||.||. ....  ..               ..|.|||||||. |.| ..|. .||. |. .
eysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptn

VTLLRGNHESRQITQVYGFYDECLRKYGNSN---VWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDR-IQEVPHEGPMCDLLWSDPDDR
  |||||||.. |   ||| .|   ..|...   .|. | . |  .||.|||  .|.|.|||.|| ...|..|. ..| ..|| ..    |||..|| | 
yillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldv

GGWGISPRGAGYTFG--QDISETFNHS--------NGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSF
 .  . ..   |..   ...| .||..         .| || |||| . ||...  |....|.||||.|     |. |....| . | | 
qllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsi

subfamily_PPPLV_pd Subfamily PPPLV 38-288 1.7e-53 174.8 In-house 3-276 (290) alignment
Range on Protein: 38-288
Range on HMM: 3-276/290.0
KTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLM----ELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRGNHESRQIT
 .||..| .|| .| .. |.. |. | ||.||...||.     |...| .   ...||.||||||| .||| .. |. ||. |  .| ||||||| . ..
lslcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvq

QVYGFYDECLRKYGNS--NVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRI----QEVPHEGPM-CDLLWSDPDDR-----------
. . .. |.  |.|.|  .||. |.. || .||.| .| ..|| |.|.  .| |  .| |.. |    ..  .  |.  |.|||||..            
esieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvl

--GGWGISPRGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRcGNQAAMVELD
  |    . || |. |..|  |.| . |.|  . |||.   .|..  ..  ..||||. .||    |.||.. .|
neGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGs.sneaalilvd

Metallophos Calcineurin-like phosphoesterase 60-252 1e-43 142.9 Pfam-A 2-198 (200) alignment
Range on Protein: 60-252
Range on HMM: 2-198/200.0
PVTVCGDVHGQFHDL----MELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLL--VCLKIRYKDRVTLLRGNHESRQITQVYGFYDECL----------
...|.||.||...||    ..|.|...... ...||.||.|||| .| ||  ||   .||......| ||||||||......|||..|.|          
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

-----------------------RKYGNSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIraldriqevphegpmcdllwsdpddrggwgi
                       ..... ... .. . |.. || |||||.|.. ||.||.| .. | |                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

sprgAGYTFGQDISETFNHSNGLTLISRAHQL
    ... || |  | .   .|..|. |.|. 
....gselfgpdalekllekygvdlvlrGHtH

subfamily_PPP7C_pd Subfamily PPP7C 17-195 1.2e-38 125.9 In-house 18-202 (383) alignment
Range on Protein: 17-195
Range on HMM: 18-202/383.0
VDVDQWIEQLYECKPLSENQVKTLCEKAKEILEKEPNVQEVRC----PVTVCGDVHGQFHDLME-LFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVC
 .|.. ||.. | | |  . | ..  .||..|.. ||...|       ||||||.||.. ||.  |.| |  |.. .|.| ||.||||  ||| . .|..
deveklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillilla

LKIRYKDRVTLLRGNHESRQITQVYGFYDECLRKY--GNSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDtLDHIRALDRI
| . |   | | |||||   .   |||  |   ||   .... . . |.|  .||..|.| .|. .|||.| . | |. .  ..| 
lllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdktd.lelldkiers

subfamily_PPP7C_pd Subfamily PPP7C 204-301 1.4e-21 69.6 In-house 237-335 (383) alignment
Range on Protein: 204-301
Range on HMM: 237-335/383.0
MCDLLWSDPDD-RGGWGISPRGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFDPA
. |.|||||   .| .  . ||.|  || |... . .  .|.|. |.|.  .|||...||..|.|.||| ||     |. | | | .||.  ..|.  .
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqyqas

subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 32-82 1.9e-13 43.3 In-house 9-59 (317) alignment
Range on Protein: 32-82
Range on HMM: 9-59/317.0
LSENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGG
..|...  || .|.|.. |||   |...|||..||.||||.||. |... |
fkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnG

subfamily_YNL217W_pd Subfamily YNL217W 61-133 3.7e-10 32.7 In-house 12-80 (235) alignment
Range on Protein: 61-133
Range on HMM: 12-80/235.0
VTVCGDVHGQFHDLMELFK--MGGKSPDTNYLFMGDYVDRGYYSVETVSLLvclkirYKDRVTLLRGNHESRQIT
. | ||||| . .|.||..  .||| ..   ...|| ...|  |||.||..       || |  ..||||   . 
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvll

subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 36-82 6.3e-09 28.4 In-house 15-61 (339) alignment
Range on Protein: 36-82
Range on HMM: 15-61/339.0
QVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGG
..  || .|.|..  || . .. .|. | ||.|||| ||. .. | |
elaelchrareliwsepiflkleapicvmgdihgqfddllamldmng