Gene pph-1 in Caenorhabditis elegans

Synonym: CELE_C05A2.1, pph-1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP1C
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP150_AA protein Get Run
CeleP150_AA_12-307 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP1C_pd Subfamily PPP1C 31-305 3.5e-147 482.0 In-house 6-280 (282) alignment 
Range on Protein: 31-305
Range on HMM: 6-280/282.0
KTLDVTENEIRMVCVLARQIFMHQPMLLELEPPLKIGGDIHGQFADLLRLFNLAGYPPESNYLFLGDYVDRGPKSIETIVLLLCYKIKYPNNFFLLRGNH
|.....|.||....  ||.|...||.||||| |.|| ||||||.|||||||. .|.|||||||||||||||| .|.|||||||.||||||.|.|||||||
kevklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnh

EVANLNRIYGFYDECKRRYSVKLWKCFQDVFNCMPVAALIDNKIFCCHGGLSPNLRSLDQLKRLSRPCDVQETGLLCDVLWSDPDATVVGWAPNERGVSY
| |..|||||||||||||||.||||.|.|||||.|.|||.|.||.|.||||||.|.||.|.....||..|.|.|||||.|||||| .|.||. |.||||.
esasinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsf

VFGVDVLAQFLQKMDLDIVVRGHQVVEDGYEFFGRRGLVTVFSAPNYCGEFDNAGAVMNVDENLLCSFQILKPQS
.|| ||...||||.|||..||.||||||||||| .| ||||||||||||||||||||..|||.||.|||||||..
tfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpak
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 16-306 1.5e-135 444.0 In-house 3-296 (298) alignment 
Range on Protein: 16-306
Range on HMM: 3-296/298.0
IDQLISTLVSVKPW--HKTLDVTENEIRMVCVLARQIFMHQPMLLELEPPLKIGGDIHGQFADLLRLFNLAGYPPESNYLFLGDYVDRGPKSIETIVLLL
.|.|.. ..||     . |  ..|...  .. ||..|| .|..|.|...|.|. ||||||..||||||. ||.||..|||||||||||| ...|.|||||
vdellievlsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlll

CYKIKYPNNFFLLRGNHEVANLNRIYGFYDECKRRY-SVKLWKCFQDVFNCMPVAALIDNKIFCCHGGLSPNLRSLDQLKRLSRPCDVQETGLLCDVLWS
.||.||||||||||||||.. .||.||||.|||||| |..|.. |||||| .|..||| ..|.| |||||..|.|||||..|.|| | .|. |  |.||.
aykvkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwa

DPDATVVGWAPNERGVSYVFGVDVLAQFLQKMDLDIVVRGHQVVEDGYEFFGRRGLVTVFSAPNYCGEFDNAGAVMNVDENLLCSFQILKPQSQ
||. .| |||.|.||||.||| ||....|.|.|.|.|||.|||| ||||||  . |||.||||.|||.|||. |||.|||.| .||..|||...
dpenavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpekk
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 15-306 1e-128 421.7 In-house 2-296 (299) alignment 
Range on Protein: 15-306
Range on HMM: 2-296/299.0
NIDQLISTLVSVKPWHKTL--DVTENEIRMVCVLARQIFMHQPMLLELEPPLKIGGDIHGQFADLLRLFNLAGYPPESNYLFLGDYVDRGPKSIETIVLL
..|.|.| |..|   .|.|   | |.|.. .| .|...|..|. |||.|.|... ||||||..||||.|. ||.||..|.|||||||||| . .|.|.||
dvdellskllnvgmsekrltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitll

LCYKIKYPNNFFLLRGNHEVANLNRIYGFYDECKRRY-SVKLWKCFQDVFNCMPVAALIDNKIFCCHGGLSPNLRSLDQLKRLSRPCDVQETGLLCDVLW
||.|||||..||.||||||.  .||.||||.||..|| | .||  ||| |. ||.. || ..|.| ||||||.|..||||. |.|| |  .  |  |.||
lcfkikyperffmlrgnhecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllw

SDPDATVVGWAPNERGVSYVFGVDVLAQFLQKMDLDIVVRGHQVVEDGYEFFGRRGLVTVFSAPNYCGEFDNAGAVMNVDENLLCSFQILKPQSQ
.||| .|..| .| |||||||| ||.|. ....|.|.| | ||||.||||||  . |||.|||| |||.|||. |.|.|||||.|.|..||| ..
adpdqsvkdwlanvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpk
subfamily_PPZ_pd Subfamily PPZ 30-304 1.1e-125 412.1 In-house 20-294 (300) alignment 
Range on Protein: 30-304
Range on HMM: 20-294/300.0
HKTLDVTENEIRMVCVLARQIFMHQPMLLELEPPLKIGGDIHGQFADLLRLFNLAGYPPESNYLFLGDYVDRGPKSIETIVLLLCYKIKYPNNFFLLRGN
 | . . ..||  .|. ||..|. || |||| |..|| ||.|||.|||||||  .|.|| .|||||||||||| .|.|||.||||||||||.||||||||
tknvclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgn

HEVANLNRIYGFYDECKRRYSVKLWKCFQDVFNCMPVAALIDNKIFCCHGGLSPNLRSLDQLKRLSRPCDVQETGLLCDVLWSDPDATVVGWAPNERGVS
||.||. |.||||||||||  .|.|| | | || .|.||..  |||| |||||| | |.|......|| || . ||. |.|||||  .   |  ||||||
hecanvtrvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvs

YVFGVDVLAQFLQKMDLDIVVRGHQVVEDGYEFFGRRGLVTVFSAPNYCGEFDNAGAVMNVDENLLCSFQILKPQ
|..    . .||.|. .|.|.| | |||||||||  | |||||||||||||||| ||||.| | |||||..| | 
ycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldpl
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 35-304 6.4e-117 382.6 In-house 6-275 (280) alignment 
Range on Protein: 35-304
Range on HMM: 6-275/280.0
VTENEIRMVCVLARQIFMHQPMLLELEPPLKIGGDIHGQFADLLRLFNLAGYPPESNYLFLGDYVDRGPKSIETIVLLLCYKIKYPNNFFLLRGNHEVAN
. | .|  |    ..|.. |  ..|.. |... ||.|||..||||||. ...||..|||||||||||| . .| |.|||.||..|||||..|||||||..
ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevis

LNRIYGFYDECKRRYSVKLWKCFQDVFNCMPVAALIDNKIFCCHGGLSPNLRSLDQLKRLSRPCDVQETGLLCDVLWSDPDATVVGWAPNERGVSYVFGV
.|| |||.||.||||| .|.. ||.... .|..||.  .|.| |||||..|.|||.|..| || | ..  |  |.||.||.  | ||| | ||||..|| 
inrkygfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifga

DVLAQFLQKMDLDIVVRGHQVVEDGYEFFGRRGLVTVFSAPNYCGEFDNAGAVMNVDENLLCSFQILKPQ
.|. .. .|.|.|...||||||.||||||  . ||||||||.|.|||||. ||. |||.|  ||..|||.
nvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpa
0045823 Metallo-dependent phosphatases 13-307 3.6e-115 378.2 In-house 27-327 (473) alignment 
Range on Protein: 13-307
Range on HMM: 27-327/473.0
ELNIDQLISTLvsvkpwHKTLDVTENEIRMVCVLARQIFMHQPMLLELEPPLKIGGDIHGQFADLLRLFNLAGYPPESNYLFLGDYVDRGPKSIETIVLL
 |..|.||..|       |   ..|.... ..  |..|....|.||||.... . ||||||..|||||....|.||| ...||||.||||| |.|.. ||
lldldlliehl......kkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlell

LCYKIKYPNNFFLLRGNHEVANLNRIYGFYDECKRRYSVKLWKCFQDVFNCMPVAALIDNKIFCCHGGLSPNLRSLDQLKRLSRPCDVQETGLLCDVLWS
|..|||||.|.|||||||| ..|| .|||.||. ..|...|.. |.......|.||.|..||...||||||.|..|||.... ||... . |||.| |||
lalkikypgnvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllws

DPdATVVG--------WAPNERGVSYVFGVDVLAQFLQKMDLDIVVRGHQVVEDGYEFFGRRG------LVTVFSAPNYCGEFDNAGAVMNVDENLlCSF
||  .. |        . .. ||..|.|| |.. .||.|..||..||||..|..|||.. ...      ..||||||||||...| .||. .||.| .||
dP.weddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isf

QILKPQSQL
....| .. 
iqfdpsphp
PP2Ac_SM00156 36-304 5.8e-114 372.7 In-house 2-270 (271) alignment 
Range on Protein: 36-304
Range on HMM: 2-270/271.0
TENEIRMVCVLARQIFMHQPMLLELEPPLKIGGDIHGQFADLLRLFNLAGYPPESNYLFLGDYVDRGPKSIETIVLLLCYKIKYPNNFFLLRGNHEVANL
...|.. ..  ...|......|.|...|. . ||||||. |||||..|||.|||..|.||||||||||.|||.|.||...||.||....|||||||  ..
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

NRIYGFYDECKRRYSVKLWKCFQDVFNCMPVAALIDNKIFCCHGGLSPNLRSLDQLKRLSRPCDVQETGLLCDVLWSDPDATVVGWAPNERGVSYVFGVD
|.||||..|.||.|. .....|...|...|.|||.|.||.| ||||||.|.|||....| |. .  | |||.|.|||||. .. |..|. ||.|.||| |
nkiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFged

VLAQFLQKMDLDIVVRGHQVVEDGYEFFGRRGLVTVFSAPNYCGEFDNAGAVMNVDENLLCSFQILKPQ
.. .||.|..|. ..|.|.||..||||| .. |||.|||||||.||.|..||..|..|| .|.. ||.|
avkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 36-303 3.2e-110 361.1 In-house 9-282 (284) alignment 
Range on Protein: 36-303
Range on HMM: 9-282/284.0
TENEIRMVCVLARQIFMHQPMLLELEPPLKIGGDIHGQFADLLRLFNLAGYP------PESNYLFLGDYVDRGPKSIETIVLLLCYKIKYPNNFFLLRGN
.|.|.  .|. ||..| .... ||.| |.|| ||||||| ||| |..| |.|       |..|||||||||||| ||| |.||..||...|.. ||||||
kekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrgn

HEVANLNRIYGFYDECKRRYSVKLWKCFQDVFNCMPVAALIDNKIFCCHGGLSPNLRSLDQLKRLSRPCDVQETGLLCDVLWSDPDATVVGWAPNERGVS
||   .|. |||| |||.|||..|...||  ||.||..|....||.| |||.| .| .|.||..|.||.|. . |...|. |.||.|.|.|..  .||  
hesrpvnmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesprgag

YVFGVDVLAQFLQKMDLDIVVRGHQVVEDGYEFFGRRGLVTVFSAPNYCGEFDNAGAVMNVDENLLCSFQILKP
 ||| . . .||.|..||.||| |||| ||||||  | |||.|||| |||..||..||.||||.|..||..|||
kvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkp
0049330 Metallo-dependent phosphatases 30-306 6.3e-110 360.0 In-house 25-301 (309) alignment 
Range on Protein: 30-306
Range on HMM: 25-301/309.0
HKTLDVTENEIRMVCVLARQIFMHQPMLLELEPPLKIGGDIHGQFADLLRLFNLAGYPPESNYLFLGDYVDRGPKSIETIVLLLCYKIKYPNNFFLLRGN
.|.  ..|.|.....  |..|....|.||||. .. . ||||||. |||||....|.||| ...||||.||||| |.|.. |||..|..||.|.||||||
lklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkllypdnvfllrGN

HEVANLNRIYGFYDECKRRYSVKLWKCFQDVFNCMPVAALIDNKIFCCHGGLSPNLRSLDQLKRLSRPCDVQETGLLCDVLWSDPDATVVGWAPNERGVS
|| ..||..|||.||..|.|...||. |.|.....|.||.|..||.|.||||||.| .|||...| ||... ..||||| |||||. .. |.||| ||..
HElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpiregfapnprglg

YVFGVDVLAQFLQKMDLDIVVRGHQVVEDGYEFFGRRGLVTVFSAPNYCGEFDNAGAVMNVDENLLCSFQILKPQSQ
.||| ... .||.| .|| ..|||..|..||..|  ..|.||||||||||...|.|||. .||.|..||....| ..
vvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpl
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 38-307 1.2e-108 355.8 In-house 6-277 (284) alignment 
Range on Protein: 38-307
Range on HMM: 6-277/284.0
NEIRMVCVLARQIFMHQPMLLELEPPLKIGGDIHGQFADLLRLFNLAGYPPESNYLFLGDYVDRGPKSIETIVLLLCYKIKYPNNFFLLRGNHEVANLNR
...  . . | .|| .||||.| . |..| |||||||.||||||.  |.|  .|||||||||||| . .|||.||..||. .|| ||.||||||.. .|.
edvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslink

IYGFYDECKRRYSV-KLWKCFQDVFNCMPVAALIDNKIFCCHGGLSPNLRSLDQLKRLSRPCDVQETG-LLCDVLWSDPDATVVGWAPNERGVSYVFGVD
|||||.||.|||    ... |. ||  ||..||. ..|.| |||.|  |. . ||. . || |  |   |  |.|||||     || || |||||||| |
iygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsd

VLAQFLQKMDLDIVVRGHQVVEDGYEFFGRRGLVTVFSAPNYCGEFDNAGAVMNVDENLLCSFQILKPQSQL
 | ..|.....|.||| ||||.||||||  | |||.|||| |||.|||| ||| |..||.||| .|.|. ..
alrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrprkki
PPP_3 36-302 1.3e-105 345.3 In-house 3-270 (271) alignment 
Range on Protein: 36-302
Range on HMM: 3-270/271.0
TENEIRMVCVLARQIFMHQPMLLELEPPLKIGGDIHGQFADLLRLFNLAGYPPESNYLFLGDYVDRGPKSIETIVLLLCYKIKYPNNFFLLRGNHEVANL
.|||.. ..  ...|......|.|.. |... ||||||. |||.||. .| .||..||||||||||| ||.|...|||..|||||....||||||| ...
senelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrqi

NRIYGFYDECK-RRYSVKLWKCFQDVFNCMPVAALIDNKIFCCHGGLSPNLRSLDQLKRLSRPCDVQETGLLCDVLWSDPDATVVGWAPNERGVSYVFGV
|..|||..|.. .... |..| .|.||...|.|||||.|....||||||...||||.|.|.|...|.|.|.|.| |.|.....  |.....||....|| 
nkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFgp

DVLAQFLQKMDLDIVVRGHQVVEDGYEFFGRRGLVTVFSAPNYCGEFDNAGAVMNVDENLLCSFQILK
|| ..||.|..|....| |...|.|||.. .. .||||||||||....||||.....|.| ..|..|.
dvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 17-305 3.7e-103 337.8 In-house 3-296 (297) alignment 
Range on Protein: 17-305
Range on HMM: 3-296/297.0
DQLISTLVSVKPWHKTLD--VTENEIRMVCVLARQIFMHQPMLLELEPPLKIGGDIHGQFADLLRLFNLAGYPPESNYLFLGDYVDRGPKSIETIVLLLC
|..|  ..|     |.|   .||. .  .  || ..| .|  ..|.. |.|. ||||||| ||||||   |.|| .||||||||||||  |||||||||.
dsiiidvlsasthekllskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivllla

YKIKYPNNFFLLRGNHEVANLNRIYGFYDECKRRY-SVKLWKCFQDVFNCMPVAALIDNKIFCCHGGLSP---NLRSLDQLKRLSRPCDVQEtGLLCDVL
||.|.| |.||||||||.  .|..||||.||..|| ||... .|||||| .|.. || .||.| ||||||   .  .|| |... |. . .| .|..|.|
ykvkfpgnlfllrgnhecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierstegke.rlvadll

WSDPDATVVGWAPNERGVSYVFGVDVLAQFLQKMDLDIVVRGHQVVEDGYEFFGRRGLVTVFSAPNYCGEFDNAGAVMNVDENLLCSFQILKPQS
|.|| . . |.  |.||    || | . .   ...||.|.| ||||.||||||  | |||.|||| |||.|||. |.| .||.| |||.||.| |
wadpisglsgfmenqrgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilrpts
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 33-306 7.4e-103 336.6 In-house 6-279 (281) alignment 
Range on Protein: 33-306
Range on HMM: 6-279/281.0
LDVTENEIRMVCVLARQIFMHQPMLLELEPPLKIGGDIHGQFADLLRLFNLAGYPPESNYLFLGDYVDRGPKSIETIVLLLCYKIKYPNNFFLLRGNHEV
...|..||  |   .. ||...  | |...| .. ||.|.|| || |||.| | .||  ..||||||||||.|.|...||...||.|... .|||||||.
vqytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnhei

ANLNRIYGFYDECKRRYSVKLWKCFQDVFNCMPVAALIDNKIFCCHGGLSPNLRSLDQLKRLSRPCDVQETGLLCDVLWSDPDATVVGWAPNERGVSYVF
|..|.||||| ||. .| ..||  ||  || .|..|||.... | ||||||.| .||.|.   .|..  . ||. |.||.|||  | .|    ||.|..|
asvnkiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftf

GVDVLAQFLQKMDLDIVVRGHQVVEDGYEFFGRRGLVTVFSAPNYCGEFDNAGAVMNVDENLLCSFQILKPQSQ
| .|. .  .........|.|||| |||| .  | |.||||.||||  . ||.||. |||.|  |.. | |.|.
GknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpase
PPP_1 36-290 1.2e-102 335.8 In-house 2-264 (264) alignment 
Range on Protein: 36-290
Range on HMM: 2-264/264.0
TENEIRMVCVLARQIFMHQPMLLELEPPLKIGGDIHGQFADLLRLFNLAGYPPESNYLFLGDYVDRGPKSIETIVLLLCYKIKYPNNFFLLRGNHEVANL
.|.|.. ..  ..........|||.. .... ||||||| |||.||. .| .||.|||||||||||| .|.|...|||..|.|||...|||||||| ...
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

NRIYGFYDECK-RRYSVKLWKCFQDVFNCMPVAALIDNKIFCCHGGLSPNLRSLDQLKRLSRPCDVQETGLLCDVL-------WSDPDATVVGWAPNERG
...|||..|.. ..|| ...| ..|||...|.|||||.||...||||||.|..||| ....|  .| |.| ||| |       .||....  ..| ..||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

VSYVFGVDVLAQFLQKMDLDIVVRGHQVVEDGYEFFGRRGLVTVFSAPNYCGEFDNAGAVMNV
..|.|| || ..|||| .|....| |.|.|.||||. .| .||.|||.||. |..|.||....
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvkl
0053225 Metallo-dependent phosphatases 30-303 4e-102 334.4 In-house 17-290 (293) alignment 
Range on Protein: 30-303
Range on HMM: 17-290/293.0
HKTLDVTENEIRMVCVLARQIFMHQPMLLELEPPLKIGGDIHGQFADLLRLFNLAGYPPESNYLFLGDYVDRGPKSIETIVLLLCYKIKYPNNFFLLRGN
 ..  ..|.|..... .|..|....|.||||. .. . |||||...|||.|....|.|||....||||.||||| |.|.. |||..|..||.|..|||||
lllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllypdnvvllrGN

HEVANLNRIYGFYDECKRRY-SVKLWKCFQDVFNCMPVAALIDNKIFCCHGGLSPNLRSLDQLKRLSRPCDVQETGLLCDVLWSDPDaTVVGWAPNERGV
|| ..|| .|||.||..|.| . .||. ..|.....|.||||..||...||||||.| .|||.... ||... ..|||.| ||||||  . ||.|. ||.
HElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpd.lwsgwlpsyrgl

SYVFGVDVLAQFLQKMDLDIVVRGHQVVEDGYEFFGRRGLVTVFSAPNYCGEFDNAGAVMNVDENLLCSFQILKP
..||| ... .||.| .|| ..|||||| |||...  ..||||||||||.|...|.|||. .||.|...|....|
gvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfap
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 90-305 2.6e-99 325.4 In-house 101-316 (317) alignment 
Range on Protein: 90-305
Range on HMM: 101-316/317.0
SNYLFLGDYVDRGPKSIETIVLLLCYKIKYPNNFFLLRGNHEVANLNRIYGFYDECKRRYSVKLWKCFQDVFNCMPVAALIDNKIFCCHGGLSPNLRSLD
..|||||||||||| ||| ..||...|..||.. ||||||||  ..|. |||| |.|.|||..|...|| .||..|..|....||.| |||.| .| .|.
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldlk

QLKRLSRPCDVQETGLLCDVLWSDPDATVVGWAPNERGVSYVFGVDVLAQFLQKMDLDIVVRGHQVVEDGYEFFGRRGLVTVFSAPNYCGEFDNAGAVMN
||..| ||.|. . |.|.|. |.||||.| |... .|| . ||| . . .||.|.|||.|||.|||||||||||  | |||.||||.|||..||..||..
qldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavls

VDENLLCSFQILKPQS
||..| .|...|.|.|
vdkklkisinvlrpes
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 32-305 3.9e-96 314.3 In-house 7-283 (287) alignment 
Range on Protein: 32-305
Range on HMM: 7-283/287.0
TLDVTENEIRMVCVLARQIFMHQPMLLELEPPLKIGGDIHGQFADLLRLFNLAGYPPESNYLFLGDYVDRGPKSIETIVLLLCYKIKYPNNFFLLRGNHE
.  .....|  |   ...|.   | |||.| |..| ||||||. ||||.||  |..|. .|||||||||||.||.| ..||...||.||..  |||||||
ldafsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhe

VANLNRIYGFYDECKRRYSVKLWKCFQDVFNCMPVAALIDNKIFCCHGGLSPNLRSLDQLKRLSRPCDVQET--GLLCDVLWSDPDATVVGWAPNE-RGV
| ..|..|||..| ||... .|.| |.|||. .|. | ....|.| |||.||.|.|||.|| |..|    .   ||  |.||.||.    . ..|  |..
vkkinklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkirai

SYVFGVDVLAQFLQKMDLDIVVRGHQVVEDGYEFFGRRGLVTVFSAPNYCGEFDNAGAVMNVDENLLCSFQILKPQS
| |||  .. ..|.|.|.|..|| |.|.|.||.|.  . |||||||| |.||  | |||. |.. |  ||  |||. 
svvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkped
subfamily_PPP4C_pd Subfamily PPP4C 34-304 5.6e-95 310.9 In-house 15-285 (288) alignment 
Range on Protein: 34-304
Range on HMM: 15-285/288.0
DVTENEIRMVCVLARQIFMHQPMLLELEPPLKIGGDIHGQFADLLRLFNLAGYPPESNYLFLGDYVDRGPKSIETIVLLLCYKIKYPNNFFLLRGNHEVA
 ..|.|.. .|  ||.|....  . ... |  . ||||||| |||.||...|  || |||||||.||||  |.||..|||..|..||..  |.|||||  
likeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesr

NLNRIYGFYDECKRRY-SVKLWKCFQDVFNCMPVAALIDNKIFCCHGGLSPNLRSLDQLKRLSRPCDVQETGLLCDVLWSDPDATVvGWAPNERGVSYVF
.. ..||||||| |.| |...|.   .||. ...||.||.|||| ||||||....||... . |  .| . | |||.|||||. .  |||   ||  |.|
qitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedae.gwavsprgagylf

GVDVLAQFLQKMDLDIVVRGHQVVEDGYEFFGRRGLVTVFSAPNYCGEFDNAGAVMNVDENLLCSFQILKPQ
| || .|| .. |.....| ||.| .|| .  .. ..||.||||||    |  |....||.|   |.|.. .
gsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaa
subfamily_PPP2C_pd Subfamily PPP2C 30-304 1.8e-94 309.2 In-house 12-286 (290) alignment 
Range on Protein: 30-304
Range on HMM: 12-286/290.0
HKTLDVTENEIRMVCVLARQIFMHQPMLLELEPPLKIGGDIHGQFADLLRLFNLAGYPPESNYLFLGDYVDRGPKSIETIVLLLCYKIKYPNNFFLLRGN
...  ..|.|.. .|  |..|....  . |.. |. . ||.|||| ||| ||.. |  |..||||||||||||  |.||. || . |..|..   .||||
keckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgn

HEVANLNRIYGFYDECKRRYS-VKLWKCFQDVFNCMPVAALIDNKIFCCHGGLSPNLRSLDQLKRLSRPCDVQETGLLCDVLWSDPDaTVVGWAPNERGV
||  .. ..||||||| |.|.  ..|| | |.|...|..||.|..||| ||||||.. .||... | |  .| . | |||.||||||    ||.  .|| 
hesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpd.drggwgisprga

SYVFGVDVLAQFLQKMDLDIVVRGHQVVEDGYEFFGRRGLVTVFSAPNYCGEFDNAGAVMNVDENLLCSFQILKPQ
 | || |.  .| .. .| ...| ||.| .||..   | .||.|||||||    | .|....|..|  ||   .| 
gytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpa
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 36-303 1.4e-93 306.4 In-house 7-274 (280) alignment 
Range on Protein: 36-303
Range on HMM: 7-274/280.0
TENEIRMVCVLARQIFMHQPMLLELEPPLKIGGDIHGQFADLLRLFNLAGYPPESNYLFLGDYVDRGPKSIETIVLLLCYKIKYPNNFFLLRGNHEVANL
|  ||  .  .   |||..  | | | |.|. |||| |. |. |||.| |  || . .||||||||||. || ..||.| ||.| .  .|||||||  ..
tgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsv

NRIYGFYDECKRRYSVKLWKCFQDVFNCMPVAALIDNKIFCCHGGLSPNLRSLDQLKRLSRPCDVQETGLLCDVLWSDPDATVVGWAPNERGVSYVFGVD
|.||||| ||. .| | ||  || .|| ||...|| ....| ||||||.|  || .. . |||.  . ||| |.|||||     ||  . ||.||.||  
nkiygfyvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkg

VLAQFLQKMDLDIVVRGHQVVEDGYEFFGRRGLVTVFSAPNYCGEFDNAGAVMNVDENLLCSFQILKP
|. |  . ...|...|.||||.||||..  | |.|||| |||| .| || ||. .. ||  ||| | |
vveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlip
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 29-304 1.6e-87 286.2 In-house 10-289 (290) alignment 
Range on Protein: 29-304
Range on HMM: 10-289/290.0
WHKTLDVTENEIRMVCVLARQIFMHQPMLLELEPPLKIGGDIHGQFADLLRLFNLAGYPPESNYLFLGDYVDRGPKSIETIVLLLCYKIKYPNNFFLLRG
.  .   ....|  .   ...|.   | |||.| |. | ||||||. .||| |.  ||||. ..||||||||||.||.|  .||.||||.|...  ||||
ygvldafsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrg

NHEVANLNRIYGFYDECKRRYSVKLWKCFQDVFNCMPVAALIDNKIFCCHGGLSPNLRSLDQLKRLSRPCDV--QETGLLCDVLWSDPDA-TVVGWAP-N
|||| ..||.|||..|  |. . .||| .||||. ... | ...||.| |||.|... | . || | .|      . ||  |.||.||.       |   
nhevrkvnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnk

ERGVSYVFGVDVLAQFLQKMDLDIVVRGHQVVEDGYEFFGRRGLVTVFSAPNYCGEFDNAGAVMNVDENLLCSFQILKPQ
 |..| ||| ..| ..|.|. |...|| |.| |.|..|   . |||||||| |.|.  | ||...| | |  |. .|||.
qraisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkpr
subfamily_PPP6C_pd Subfamily PPP6C 34-299 3.8e-86 281.8 In-house 14-279 (290) alignment 
Range on Protein: 34-299
Range on HMM: 14-279/290.0
DVTENEIRMVCVLARQIFMHQPMLLELEPPLKIGGDIHGQFADLLRLFNLAGYPPESNYLFLGDYVDRGPKSIETIVLLLCYKIKYPNNFFLLRGNHEVA
 ..||... .| |  ......  .  .. |. . ||||||| ||. ||. .|  |...|.||||.||||  |.||. .||. |.|||..  |||||||  
ylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesr

NLNRIYGFYDECKRRYS-VKLWKCFQDVFNCMPVAALIDNKIFCCHGGLSPNLRSLDQLKRLSRPCDVQETGLLCDVLWSDPDaTVVGWAPNERGVSYVF
.. ..|||||||...|  .. || . .||. ...||.||....| ||||||... |||.. ..|  .. . | .||..||||.  |  ||  .||  |.|
qitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpe.dvetwavsprgagylf

GVDVLAQFLQKMDLDIVVRGHQVVEDGYEFFGRRGLVTVFSAPNYCGEFDNAGAVMNVDENLLCSFQ
|  |  .|..  .|....| ||.||.|....    ||||.||||||    |  ........   ...
gskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereak
subfamily_PPP3C_pd Subfamily PPP3C 35-295 8.1e-82 268.4 In-house 41-314 (452) alignment 
Range on Protein: 35-295
Range on HMM: 41-314/452.0
VTENEIRMVCVLARQIFMHQPMLLELEPPLKIGGDIHGQFADLLRLFNLAGYPPESNYLFLGDYVDRGPKSIETIVLLLCYKIKYPNNFFLLRGNHEVAN
..|...  .   | ... ... |||.| |. . ||||||| |||.||...| | ...|||||||||||  |||... |.. ||.||...||||||||   
leeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrh

LNRIYGFYDECKRRYSVKLWKCFQDVFNCMPVAALIDNKIFCCHGGLSPNLRSLDQLKRLSRPCDVQETGLLCDVLWSDPDA------TVVGWAPNE-RG
|   . | .||| .|| .... . . |...|.|||.... .|.||||||...|||..|.| |  .. ..|.|||.|||||        |   . ||. ||
lteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpnsvrG

VSYVFGVDVLAQFLQKMDLDIVVRGHQVVEDGYEFFGR------RGLVTVFSAPNYCGEFDNAGAVMNVDENLL
 ||...    ..|||| ||  ..| |.. ..||. . .        |.|.||||||.. ..| .||.....| .
csyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennvm
subfamily_PPP5C_pd Subfamily PPP5C 37-294 1.3e-81 267.1 In-house 36-299 (322) alignment 
Range on Protein: 37-294
Range on HMM: 36-299/322.0
ENEIRMVCVLARQIFMHQPMLLELEPP----LKIGGDIHGQFADLLRLFNLAGYPPES-NYLFLGDYVDRGPKSIETIVLLLCYKIKYPNNFFLLRGNHE
.  . .. . |.... ..| |.|.. .    | . ||||||| ||| .|.| |.| |.  ||| ||.||||  |.|.|..||..|. |||.||| |||||
kkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhe

VANLNRIYGFYDECKRRYSVKLWKCFQDVFNCMPVAALIDNKIFCCHGGLS-PNLRSLDQLKRLSRPCDVQETGLLCDVLWSDPDATvVGWAPNERGVSY
  |.|..||| .|.| .|. |. . |..||| .|.| .|..|.. .||||   .  .||.|....| ..  | |||...|||||. .  | .| .|||. 
sdnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqea.nGrspskrGvgv

VFGVDVLAQFLQKMDLDIVVRGHQVVEDGYEFFGRRGLVTVFSAPNYCGEFDNAGAVMNV-DENL
 || ||  .||.. .|. ..| |.| |.|||.     |.||||||||| . .| ||.... ...|
qfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddl
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 91-306 4.2e-81 265.7 In-house 121-336 (339) alignment 
Range on Protein: 91-306
Range on HMM: 121-336/339.0
NYLFLGDYVDRGPKSIETIVLLLCYKIKYPNNFFLLRGNHEVANLNRIYGFYDECKRRYSVKLWKCFQDVFNCMPVAALIDNKIFCCHGGLSPNLRSLDQ
 |||||||||||| |.| ..|| . |. ||.  .|||||||   .|  |||| | . ||  .|..|||..|| .|..|.|.| |.| |||.|  | |..|
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfnq

LKRLSRPCDVQETGLLCDVLWSDPDATVVGWAPNERGVSYVFGVDVLAQFLQKMDLDIVVRGHQVVEDGYEFFGRRGLVTVFSAPNYCGEFDNAGAVMNV
.  . || .. . |.| |. |.||| |  |. |  || |.|||   |  ||.|.||..|.|||||||||||||  | |||.||||||||. ||. ||. .
fsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfsi

DENLLCSFQILKPQSQ
|..|  | ....|.|.
dkklkisinvfrpesr
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 31-308 2.2e-78 256.5 In-house 16-296 (307) alignment 
Range on Protein: 31-308
Range on HMM: 16-296/307.0
KTLDVTENEIRMVCVLARQIFMHQPMLLELEPPLKIGGDIHGQFADLLRLFNLAGYPPESNYLFLGDYVDRGPKSIETIVLLLCYKIKYPNNFFLLRGNH
. .. | .|.  |   |. ||  .  |....||  . ||.|||| ||. .| | | |||. |.| |||||||  |.|.|.||..||| ||.|  ||||||
hkiqytkeefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnh

EVANLNRIYGFYDECKR---RYSVKLWKCFQDVFNCMPVAALIDNKIFCCHGGLSPNLRSLDQLKRLSRPCDVQETGLLCDVLWSDPDATVVGWAPNERG
|.| .|. ||||.||     .   ..|  || .|| .|..|||  ||.| |||||| |  ||.|.   .|      |.. |.||.||| .|. |    ||
eiarvnkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrg

VSYVFGVDVLAQFLQKMDLDIVVRGHQVVEDGYEFFGRRGLVTVFSAPNYCGEFDNAGAVMNVDENLLCSFQILKPQSQLV
  . || .|. .  ... .....| ||.. |||  .  | |.|.|||| ||  . |||.|..||| |      . |.|. .
sgftfgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpeseni
subfamily_PPG1_pd Subfamily PPG1 35-300 3e-78 256.1 In-house 14-292 (300) alignment 
Range on Protein: 35-300
Range on HMM: 14-292/300.0
VTENEIRMVCVLARQIFMHQPMLLELEPPLKIGGDIHGQFADLLRLFNLAGYPPESNYLFLGDYVDRGPKSIETIVLLLCYKIKYPNNFFLLRGNHEVAN
. |  .. ..   .......  . |.. |. . ||.|||| |.| .|.. |  |..||||||||||||  |.|||.||.. |..||    |||||||  .
lpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrq

LNRIYGFYDECKRRY--SVKLWKCFQDVFNCMPVAALIDNKIFCCHGGLSPNLRSLDQLKRLSRPCDVQETGLLCDVLWSDPD---------ATVVG--W
. ..|||| || |.|    ..|| . ..|. . .||.||..|.| ||||||. .|.||.| | |  .| . | |.|.|||||.             |  .
itqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqhf

APNERGVSYVFGVDVLAQFLQKMDLDIVVRGHQVVEDGYEFFGRRGLVTVFSAPNYCGEFDNAGAVMNVDENLLCSFQI
   .||  | .| ||  .||.. |.. ..| ||.. .||. .    | ||.||||||    |  ..... |..   |..
vvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnv
PPP_2 65-255 1.2e-75 246.6 In-house 2-197 (198) alignment 
Range on Protein: 65-255
Range on HMM: 2-197/198.0
KIGGDIHGQFADLLRLFNLAGYPPESNYLFLGDYVDRGPKSIETIVLLLCYKIKYPNNFFLLRGNHEVANLNRIYGFYDECK-RRYSVKLWKCFQDVFNC
.. ||.|||. |||.||. .. .||..||||||||||| ||.|...|||..|..||....||||||| ...|..|||..|.. .... |..| .|.||..
tvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfel

MPVAALIDNKIFCCHGGLSPNLRSLDQLKRLSRPCDVQETGLLCDVL----WSDPDATVVGWAPNERGVSYVFGVDVLAQFLQKMDLDIVVRGHQV
.|.|||||.|....|||||.....||| |. .|.....|.|.|.| |    .|||...  ..|...||....|| || ...|.|..|....| |.|
LplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 66-255 2.9e-73 239.1 In-house 3-196 (197) alignment 
Range on Protein: 66-255
Range on HMM: 3-196/197.0
IGGDIHGQFADL-LRLFNLAGYPP-ESNYLFLGDYVDRGPKSIETIVLLLCYKIKYPNNFFLLRGNHEVANLNRIYGFYDECKRRYSVKLWKCFQDVFNC
. ||||||. || |.|....| |. |..|.|||||||||..|.|...|||..|..||....||||||| ..||..|||..|...... ...| .||||..
vvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvfdl

MPVAALIDNKIFCCHGGLSPNLRSLDQLKRLSRPCDVQ-ETGLLCDV-LWSDPDATVVGWAPNERGVSYVFGVDVLAQFLQKMDLDIVVRGHQV
.|.|||||.|....|||||..|.|||...|..|..... | ....|  |||||  .  |.|...||....|| ||  .||.| .|....|.|..
lplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 57-305 5.2e-71 232.4 In-house 2-257 (263) alignment 
Range on Protein: 57-305
Range on HMM: 2-257/263.0
LLELEPPLKIGGDIHGQFADLLRLFNLAGYPPESNYLFLGDYVDRGPKSIETIVLLLCYKIKYPNNFFLLRGNHEVANLNRIYGFYDECKRRYSV-----
||||. |..| || |||. ||||.|| .|   ...||||||||||| .|.| |.||.  |.  | ...|||||||.  .|. |||. | |.|.       
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

KLWKCFQDVFNCMPVAALIDNKIFCCHGGLSPNLRSLDQLKRLSRPCDVQET-GLLCDVLWSDPDATVVGWAPNE-RGVSYVFGVDVLAQFLQKMDLDIV
 ... |..||. ||..|.. ..|.| |||.|| |.|||... .  | .  .|  | ||.||.||.    |. ||. | .| |||   . .. ...|.|..
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidli

VRGHQVVEDGYEFFGRRGLVTVFSAPNYCGEFDNAGAVMNVDENLLCSFQILKPQS
|| ||||| || ||  | |.|||||  |  |. |  ||. |.. |  ||  |||. 
vrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkped
PPP_5_Dcr2 66-256 8.9e-70 227.7 In-house 3-199 (199) alignment 
Range on Protein: 66-256
Range on HMM: 3-199/199.0
IGGDIHGQFADL-LRLFNLAGYPP-ESNYLFLGDYVDRGPKSIETIVLLLCYKIKYPNNFFLLRGNHEVANLNRIYGFYDECKRR-YSVKLWKCFQDVFN
. ||.|||. || |.||. .| |. | .|.|||||||||..|.|...|||..|..||....|||||||  .||.||||..|.... .. |..| ..|||.
vcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdvfd

CMPVAALIDNKIFCCHGGLSPNLRSLDQLKRLSRPCDVQ-ETGLLCDV-LWSDPDATVVG-WAPNERGVSYVFGVDVLAQFLQKMDLDIVVRGHQVV
..|.|||||.|....||||||...|...|... |..... |.|  .|  |||||  .. | ....|||....|| ||  .||.| .|. ..|.|...
wlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 34-304 1.1e-67 221.3 In-house 5-300 (302) alignment 
Range on Protein: 34-304
Range on HMM: 5-300/302.0
DVTENEIRMVCVLARQIFMHQPMLLELEPPLKIGGDIHGQFADLLRLFNLAGYP-----------PESNYLFLGDYVDRGPKSIETIVLLLCYKIKYPNN
. ...|. ...    . . ..  | |. ||. | ||||||| ||.|..|                 .. ..|||||||||.|||| | |....|. ||.|
eysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptn

FFLLRGNHEVANLNRIYGFYDECKRRYS----VKLWKCFQDVFNCMPVAALIDNKIFCCHGGLSPNLRSLDQLKRLSRPC-DVQETGLLCDVLWSDPDA-
. |||||||.  .|  ||| .| . |..     ..|. |..||  ||.|||. .||.| |||.||.|.||...|...||  .|.|  |  |.|..||   
yillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldv

T---VVG----WAPN-ERGVSYVFGVDVLAQFLQKMDLDIVVRGHQVVEDGYEFFGRRGLVTVFSAPNYCGEFDNAGAVMNVDENLLCSFQILKPQ
    .|     .| |  ||.|.||    . .. ....|...||.||..  |. ||  . |.|.||||.|  | || |||..|| |   | ..|...
qllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrnk
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 34-304 2.4e-67 220.2 In-house 6-301 (302) alignment 
Range on Protein: 34-304
Range on HMM: 6-301/302.0
DVTENEIRMVCVLARQIFMHQPMLLELEPPLKIGGDIHGQFADLLRLFNLAGYP-----------PESNYLFLGDYVDRGPKSIETIVLLLCYKIKYPNN
. ...|. ...    . . ..  | |. ||. | ||||||| ||.|..|                 .. ..|||||||||.|||| | |....|. ||.|
eysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptn

FFLLRGNHEVANLNRIYGFYDECKRRYS----VKLWKCFQDVFNCMPVAALIDNKIFCCHGGLSPNLRSLDQLKRLSRPC-DVQETGLLCDVLWSDPDA-
. |||||||.  .|  ||| .| . |..     ..|. |..||  ||.|||. .||.| |||.||.|.||...|...||  .|.|  |  |.|..||   
yillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldv

T---VVG----WAPN-ERGVSYVFGVDVLAQFLQKMDLDIVVRGHQVVEDGYEFFGRRGLVTVFSAPNYCGEFDNAGAVMNVDENLLCSFQILKPQ
    .|     .| |  ||.|.||    . .. ....|...||.||..  |. ||  . |.|.||||.|  | || |||..|| |   | ..|...
qllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrnk
subfamily_PPPLV_pd Subfamily PPPLV 42-292 8.4e-56 182.4 In-house 4-277 (290) alignment 
Range on Protein: 42-292
Range on HMM: 4-277/290.0
MVCVLARQIFMHQPMLLELEPPLKIGGDIHGQFADLLR----LFNLAGYPPESNYLFLGDYVDRGPKSIETIVLLLCYKIKYPNNFFLLRGNHEVANLNR
 .|  | .|....  ||||. |  . ||.||.. ||      |. .      ...||||||||||. |.| |  ||  |. ||  ..|||||||.  .  
slcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqe

IYGFYDECKRRYSVKL---WKCFQDVFNCMPVAALIDNKIFCCHGGLSPNLRS-------LDQLKRLSrpCDVQETGLLCDVLWSDPDA-----------
 . .. |.. ..  .|   |. |..||. .|.|| ||.|.||.|.|.     .        | |.||    |.. . |  |.|||||.            
sieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlk..ddidgaplaldilwsdpaedrdlslrgelv

TVVGWAPNE-RGVSYVFGVDVLAQFLQKMDLDIVVRGHQVVEDGYEFFGRRGLVTVFSAPNYCGEFDNAgAVMNVDE
.  |...|. || ..||. | | .||.. .|. |.| |.| | |...  .  |.||||. .|||  ..| |.. ||.
lneGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssnea.alilvdk
Metallophos Calcineurin-like phosphoesterase 68-255 2.8e-43 141.5 Pfam-A 7-198 (200) alignment 
Range on Protein: 68-255
Range on HMM: 7-198/200.0
GDIHGQFADL----LRLFNLAGYPPESNYLFLGDYVDRGPKSIETIVLL--LCYKIKYPNNFFLLRGNHEVANLNRIYGFYDECK---------------
||.||...||    |.|...|....  ..|||||.||||. |.||. ||  |..|...|...||||||||. ..|  |||..|.                
gDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglangeeeyen

-------------------RRYSVKLWKCFQDVFNCMPVAALIDNKIFCCHGGLSPNLRSLDQLkrlsrpcdvqetgllcdvlwsdpdatvvgwapnerg
                    ..  . .  ....|...| .||.|.||...||.||. . | |.                                     
lkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi....................................

VSYVFGVDVLAQFLQKMDLDIVVRGHQV
 |. || |.|  .|.| ..|.|.|||. 
gselfgpdalekllekygvdlvlrGHtH
subfamily_PPP7C_pd Subfamily PPP7C 65-196 4.3e-38 124.0 In-house 67-201 (383) alignment 
Range on Protein: 65-196
Range on HMM: 67-201/383.0
KIGGDIHGQFADLLRLFNLAGYPPE-SNYLFLGDYVDRGPKSIETIVLLLCYKIKYPNNFFLLRGNHEVANLNRIYGFYDECKRRY---SVKLWKCFQDV
 . ||.||.. ||| ..   |.| |  .|.| ||.|||| .|.| ...||.. . ||....| |||||   ||  |||  | . .|   . |. . ..||
tvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledv

FNCMPVAALIDNKIFCCHGGLSpNLRSLDQLKRLSR
|  .|.|.|||.||. .|||.| .  .|. |....|
fawlplatlidekilivhGGis.dktdlelldkier
subfamily_PPP7C_pd Subfamily PPP7C 197-297 1.9e-21 69.3 In-house 228-328 (383) alignment 
Range on Protein: 197-297
Range on HMM: 228-328/383.0
PCDVQETGLLCDVLWSDPDATVVGWAPNERGVSYVFGVDVLAQFLQKMDLDIVVRGHQVVEDGYEFFGRRGLVTVFSAPNYCGEFDNAGAVMNVDENLLC
..| .|   . |.||||| |.   ..   ||    || || ...||| .|....| |.   .||||   . ..|.||| ||  |  | || ... ..|  
kvdkeewrqvldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltp

S
 
r
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 36-88 7.4e-15 47.9 In-house 10-62 (317) alignment 
Range on Protein: 36-88
Range on HMM: 10-62/317.0
TENEIRMVCVLARQIFMHQPMLLELEPPLKIGGDIHGQFADLLRLFNLAGYPP
.|.|.  .|  ||..| ..|. |||| |..| ||||||| ||| |..| |.| 
kekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwpl
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 37-90 4.6e-10 32.1 In-house 13-66 (339) alignment 
Range on Protein: 37-90
Range on HMM: 13-66/339.0
ENEIRMVCVLARQIFMHQPMLLELEPPLKIGGDIHGQFADLLRLFNLAGYPPES
  |.  .|  ||..   .|..|.|| |. . ||||||| ||| .... |.|  |
aaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmngwplss
subfamily_YNL217W_pd Subfamily YNL217W 67-137 2.9e-07 23.2 In-house 15-81 (235) alignment 
Range on Protein: 67-137
Range on HMM: 15-81/235.0
GGDIHGQFADLLRLFN--LAGYPPESNYLFLGDYVDRGPKSIETIVLLlcykikYPNNFFLLRGNHEVANLNR
 ||.|| . .|..|..    |  ..   ...|| ...||||.|.. ..        ..   ..|||| . | .
vGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvlla