Gene pph-5 in Caenorhabditis elegans

Synonym: CELE_Y39B6A.2, pph-5

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP5C
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP154_AA protein Get Run
CeleP154_AA_165-491 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP5C_pd Subfamily PPP5C 171-491 1.1e-181 595.9 In-house 1-322 (322) alignment 
Range on Protein: 171-491
Range on HMM: 1-322/322.0
AIEDSYDGPRLED-KITKEFVLQLIKTFKNQQKLHKKYAFKMLLEFYNYVKSLPTMVEITVPTGKKFTICGDVHGQFYDLCNIFEINGYPSETNPYLFNG
..|||||||.||. ||||||| .|...||.|.|||||||.|.|||.....|.||..||||....||.|.|||.|||||||.||||.||.|||.|||||||
tvedsydgpkleeekitkefvkellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnG

DFVDRGSFSVETIFTMIGFKLLYPNHFFMSRGNHESDVMNKMYGFEGEVKAKYTQQMCDMFTETFCWLPLCHLINEKIFVCHGGLFKEDGVTLEDIRKTD
|||||||||||.|.|..|||||||||||.|||||||| |||.||||||||||||....|.|||.|.||||.|.||||..|.|||||.||||||.|.||.|
dfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkid

RNRQPPDEGIMCDLLWSDPQPINGRSPSKRGVGCQFGPDVTSKWCETNGIEYVVRSHEVKPEGYEMHHNGQCFTVFSAPNYCDQMNNKGAFITITGDNLT
||.|||.||....|||||||. |||||||||||.|||||||.|....|..|...|||||| ||||..|.|...||||||||||||.|||||||..||.|.
rnaqppeegllvellwsdpqeanGrspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlk

PRFTPFDAVPHPKLPPMAYANS
..|. |.||.||...|||||||
lkfktfeavehpdvkpmayans
0045823 Metallo-dependent phosphatases 166-491 1.3e-109 359.9 In-house 6-337 (473) alignment 
Range on Protein: 166-491
Range on HMM: 6-337/473.0
DINAMAIEDSYDGPRLEDKITKEFVLQLIKTFKNQQKLHKKYAFKMLLEFYNYVKSLPTMVEITVptgkKFTICGDVHGQFYDLCNIFEINGYPSEtNPY
..  . . .....|.| . ... .. .||...|....|......|.| |.... |. |...|..     .....||.|||..||....|..|.|.| . .
klvlipvlrlltlpllfillglldldlliehlkkegllpeedllklldeakeilkkepnllelsm....rivviGDiHGqlddLlrllekigfppe.drl

LFNGDFVDRGSFSVETIFTMIGFKLLYPNHFFMSRGNHESDVMNKMYGFEGEVKAKYTQQMCDMFTETFCWLPLCHLINEKIFVCHGGLFKEDgVTLEDI
.|.||.||||..|.|..  .. .|..||...|. |||||. ..| .||| .|. .||.... ..| | ...|||...|..||...||||. .   .|..|
vflGDlvDrGpdslevlelllalkikypgnvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdl.plldqi

RKTDRNRQPPDEGIMCDLLWSDPQPING--------RSPSKRGVGCQFGPDVTSKWCETNGIEYVVRSHEVKPEGYEMHHNGQ------CFTVFSAPNYC
|. .| ...||.|...|||||||....|        . .|.||.|..||||.. .... ||. ..||.|.. |||||....|.      ..|||||||||
reierpleipddgllldllwsdPweddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYc

DQMNNKGAFITITGDNltPRFTPFDAVPHPKLPPMAYANS
....|..|...|..|   . |. ||..|||.. |... . 
grggnlaAvlvidedl..isfiqfdpsphplilplfldvf
PP2Ac_SM00156 204-472 9.2e-98 319.6 In-house 2-264 (271) alignment 
Range on Protein: 204-472
Range on HMM: 2-264/271.0
HKKYAFKMLLEFYNYVKSLPTMVEITvptgKKFTICGDVHGQFYDLCNIFEINGyPSETNPYLFNGDFVDRGSFSVETIFTMIGFKLLYPNHFFMSRGNH
.|......| |  . .|. ...||..    .. |..||.|||..|| ...| .| ......|.|.||.||||..|.|.| ... .|.|||..... ||||
skeevlelleevkeilkqeknlvevs....apvtvvGdihGqlddllrllelag.eppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnH

ESDVMNKMYGFEGEVKAKYTQQMCDMFTETFCWLPLCHLINEKIFVCHGGLFKeDGVTLEDIRKTDRNRQPPDEGIMCDLLWSDP-QPINGRSPSKRGVG
||. .||.|||| |||.||.... ..|.|.| .|||. |...||.. |||| . .  .|.|||| .|....|.||...||||||| |. .| .|||||..
EsssvnkiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlsp.eleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrgls

CQFGPDVTSKWCETNGIEYVVRSHEVKPEGYEMHHNGQCFTVFSAPNYCDQMNNKGAFITItGDNLTPRF
..||.|.... ...| .....|.|||..||||. ..... |.||||||||...||.|....  .||....
vvFgedavkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkv.eknlklsi
0049330 Metallo-dependent phosphatases 178-484 1e-95 313.4 In-house 5-305 (309) alignment 
Range on Protein: 178-484
Range on HMM: 5-305/309.0
GPRLEDKITKEFVLQLIKTFKNQQKLHKKYAFKMLLEFYNYVKSLPTMVEITvptgKKFTICGDVHGQFYDLCNIFEINGYPSEtNPYLFNGDFVDRGSF
.|.| ........ .||........|........||......|| |...|..     .....||.|||..|| ...|..|.|.| . ..|.||.||||..
dpllllelilslldllielllklkllseeellllllkakeilksepnllels....mrivviGDiHGqlddLlrllekigfppe.drlvflGDlvdrGpd

SVETIFTMIGFKLLYPNHFFMSRGNHESDVMNKMYGFEGEVKAKYTQQMCDMFTETFCWLPLCHLINEKIFVCHGGLFKEDgVTLEDIRKTDRNRQPPDE
|.|.. ... .|||||...|. |||||. ..| .||| .|...|| ... ..|......|||...|..||...||||. .  ..|..||. .| ...|..
slevlllllalkllypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdl.llldqirelerpleipld

GIMCDLLWSDPQ-PINGRSPSKRGVGCQFGPDVTSKWCETNGIEYVVRSHEVKPEGYEMHHNGQCFTVFSAPNYCDQMNNKGAFITItGDNLTPRFTPFD
|..||||||||.  ..|  |..||.|. ||.... .....||.....|.|.. ..||.....|...|||||||||....|.||...| ...|...|. |.
gllcdllwsdplpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavlei.dedlvisfllfe

AVPHPKLP
.||.. |.
pvplllll
PPP_3 210-466 2e-95 311.9 In-house 5-261 (271) alignment 
Range on Protein: 210-466
Range on HMM: 5-261/271.0
KMLLEFYNYVKSLPTMVEITVPTGKKFTICGDVHGQFYDLcNIFEINGYPSETNPYLFNGDFVDRGSFSVETIFTMIGFKLLYPNHFFMSRGNHESDVMN
. | |  . .|....  ...| . .. |.|||.|||..|| .... || ||... |||.||.||||..|.|...... .|..||..... ||||||. .|
nelkelvkklkeilekesnlveisapvtvcGDiHGqldDL.lelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrqin

KMYGFEGEVK-AKYTQQMCDMFTETFCWLPLCHLINEKIFVCHGGLFKEDGvTLEDIRKTDRNRQPPDEGIMCDL-LWSDPQPINGRSPSKRGVGCQFGP
|.|||. ||.  |..... ....|.|..|||..||.||..|.||||...   .|..|.|..|... |.|| ..|| |.|||.  .| ..||||.|. |||
kvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsik.sldqikklerkievpeegklldlllssdpekeeglenskrGagllFgp

DVTSKWCETNGIEYVVRSHEVKPEGYEMHHNGQCFTVFSAPNYCDQMNNKGAFITITGD
|||.. .|.| .....|.||.|.||||..|.|.. |||||||||....|.||..... .
dvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleea
PPP_1 211-462 8.6e-93 303.4 In-house 5-263 (264) alignment 
Range on Protein: 211-462
Range on HMM: 5-263/264.0
MLLEFYNYVKSLPTMVEITVPTGKKFTICGDVHGQFYDLcNIFEINGYPSETNPYLFNGDFVDRGSFSVETIFTMIGFKLLYPNHFFMSRGNHESDVMNK
 | |  . .|.|..  |... . .. |.|||.||||.|| ...  .| ||... |||.||.||||..|||...... .|| ||...|. ||||||. ..|
elaelkkklkellnkeenllevseeitvcGDiHGqfdDL.lklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvtk

MYGFEGEVK-AKYTQQMCDMFTETFCWLPLCHLINEKIFVCHGGLFKEDGvTLEDIRKTDRNRQPPDEGIMCDL--------LWSDPQPINGRSPSKRGV
.|||. ||.  ||.... ...|..|..|||. ||.|||...|||| .|   .|..|||..|... |.|| .|||        |..|..  .. . |.||.
vygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeld.lldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRGa

GCQFGPDVTSKWCETNGIEYVVRSHEVKPEGYEMHHNGQCFTVFSAPNYCDQMNNKGAFIT
|..||.|||.| ...|......|.||||.||||....... |.|||.||.....|.||...
gylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
0053225 Metallo-dependent phosphatases 185-479 1.5e-87 286.7 In-house 4-292 (293) alignment 
Range on Protein: 185-479
Range on HMM: 4-292/293.0
ITKEFVLQLIKTFKNQQKLHKKYAFKMLLEFYNYVKSLPTMVEITvptgKKFTICGDVHGQFYDLCNIFEINGYPSEtNPYLFNGDFVDRGSFSVETIFT
... .. .||........|........|||.....|. |...|..     .....||.||...|| ...|. |.|.| . ..|.||.||||..|.|..  
lilllldllielllllkllseeelllllleakeilkkepnllels....mriyviGDiHGnlddLlallekigfppe.drlvflGDlvdrGpdslevlel

MIGFKLLYPNHFFMSRGNHESDVMNKMYGFEGEVKAKY-TQQMCDMFTETFCWLPLCHLINEKIFVCHGGLfKEDGVTLEDIRKTDRNRQPPDEGIMCDL
.. .|||||..... |||||. ..| .||| .|...||  ... |........|||..||..||...||||   | ..|..||. .|  ..|.||...||
llalkllypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGl.spdlslldqireinrplriplegllldl

LWSDPQPINGRSPSKRGVGCQFGPDVTSKWCETNGIEYVVRSHEVKPEGYEMHHNGQCFTVFSAPNYCDQMNNKGAFITITGDnLTPRFTPFDAVP
|||||. ..|  ||.||.|. ||.... .....||.....|.|.| |.||.....|...||||||||.....|.||.... .. |...|. |..|.
lwsdpdlwsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeg.lvwgfklfapvl
subfamily_PPP1C_pd Subfamily PPP1C 203-466 1.4e-82 270.0 In-house 10-268 (282) alignment 
Range on Protein: 203-466
Range on HMM: 10-268/282.0
LHKKYAFKMLLEFYNYVKSLPTMVEITVPtgkkFTICGDVHGQFYDLCNIFEINGYPSETNpYLFNGDFVDRGSFSVETIFTMIGFKLLYPNHFFMSRGN
|...   ..| .  . ..| |...|.. |     .|.||.|||..|| ..||..|.|.|.| ||| ||.||||..|.|||  .. .|. ||...|. |||
lkeaeieallkkareillsqpilleleaP....vkivgdihGqyadllrlfetsgaPpesn.ylflGdyvdrGkqsletivlllaykikypenlfllrGn

HESDVMNKMYGFEGEVKAKYTQQMCDMFTETFCWLPLCHLINEKIFVCHGGLFKeDGVTLEDIRKTDRNRQPPDEGIMCDLLWSDPQP-INGRSPSKRGV
|||  .|..|||  |.| .|....  .||..| .|||. |..|||...|||| . .   ||.|||  |  . |..|..||||||||.  ..| | ..|||
hesasinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlsp.elksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGv

GCQFGPDVTSKWCETNGIEYVVRSHEVKPEGYEMHHNGQCFTVFSAPNYCDQMNNKGAFITITGD
  .||.|| .|... | .. .||.|.|  .|||.. . |  |||||||||....|.|| .... .
sftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdee
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 188-464 2.5e-78 256.2 In-house 9-281 (298) alignment 
Range on Protein: 188-464
Range on HMM: 9-281/298.0
EFVLQLIKTFKNQQKLHKKYAFKMLLEFYNYVKSLPTMVEITVPtgkkFTICGDVHGQFYDLCNIFEINGYPSETNpYLFNGDFVDRGSFSVETIFTMIG
|.. . ... |  ......  .|.. .  . .|. ...||.  |     ..|||.|||. ||  .|. .|.| ..| ||| ||.||||....|.|  .. 
evlsvslsekkltkvikeedveklielakkifkkqkslvevdap....ikvcGdihGqysdllrlfdkagfppdan.ylflGdyvdrGrqnlevivllla

FKLLYPNHFFMSRGNHESDVMNKMYGFEGEVKAKY-TQQMCDMFTETFCWLPLCHLINEKIFVCHGGLFKEdGVTLEDIRKTDRNRQPPDEGIMCDLLWS
.|. |||.||. |||||  ..|..|||  |.| .|  ...   | ..| .|||. || ..|.  |||| |.  ..|...|.  |  ....| .  ||||.
ykvkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskk.lksldqlrelkrpfdskeeslaidllwa

DPQP-INGRSPSKRGVGCQFGPDVTSKWCETNGIEYVVRSHEVKPEGYEMHHNGQCFTVFSAPNYCDQMNNKGAFITIT
||.  ..| ....|||...|| ||  . .|.  |. |||.| |  .|||.  . .  |.||||.||.|..|  |.... 
dpenavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvd
subfamily_PPP3C_pd Subfamily PPP3C 192-483 1.3e-75 248.0 In-house 30-327 (452) alignment 
Range on Protein: 192-483
Range on HMM: 30-327/452.0
QLIKTFKNQQKLHKKYAFKMLLEFYNYVKSLPTMVEITVPtgkkFTICGDVHGQFYDLCNIFEINGYPSETNpYLFNGDFVDRGSFSVETIFTMIGFKLL
 | . |... .|... | |.. |  . .|. .|..|.  |     |..||.||||||| ..||..| |..|. ||| ||.||||.||.|... .   |. 
vlkehflkegrleeeaalkiieeaakllkkektlleveaP....itviGdihGqfydllklfevgGdPastk.ylflGdyvdrGyfsiecvlylyalkia

YPNHFFMSRGNHESDVMNKMYGFEGEVKAKYTQQMCDMFTETFCWLPLCHLINEKIFVCHGGLFKEdGVTLEDIRKTDRNRQPPDEGIMCDLLWSDPQPI
||...|. |||||.  . . . |. |.| ||.... |...|.|  |||  |.|.. . .||||  |   .|.||.| || ..||  | .||||||||   
ypstlfllrGnhecrhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspe.ikslddikkldrfkeppasGplcdllWsdPled

NGRS--------PSKRGVGCQFGPDVTSKWCETNGIEYVVRSHEVKPEGYEMHHNGQ------CFTVFSAPNYCDQMNNKGAFITITGDNLTprFTPFDA
 | .         | ||  . ..   .... ..| .  ..|.||.. .||.|... .        |.||||||.|  |||.| . .  ...      |..
ygeekteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennvmn..irqfns

VPHPKL
.|||  
sphpyw
subfamily_PPP4C_pd Subfamily PPP4C 236-479 8.5e-74 241.3 In-house 45-286 (288) alignment 
Range on Protein: 236-479
Range on HMM: 45-286/288.0
FTICGDVHGQFYDLCNIFEINGYPSETNpYLFNGDFVDRGSFSVETIFTMIGFKLLYPNHFFMSRGNHESDVMNKMYGFEGEVKAKYTQ-QMCDMFTETF
 |.|||.||||||| ..|...|   ||| ||| ||||||| .||||.. .. .|. ||..  . ||||||  . ..|||  |.  || . ..  . || |
vtvcgdihgqfydllelfkvggdvpetn.ylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrqitqvygfydeclrkygsanvwryctevf

CWLPLCHLINEKIFVCHGGLFKeDGVTLEDIRKTDRNRQPPDEGIMCDLLWSDPQPINGRSPSKRGVGCQFGPDVTSKWCETNGIEYVVRSHEVKPEGYE
 .|.|. .|..|||. ||||   .  ||..||  ||... |.||..||||||||. ..| . | || |  || ||.....|.|.|| ..|.|..  ||| 
dylslaaiidgkifcvhgglsp.sistldeirsidrkqevphegplcdllwsdpedaegwavsprgagylfgsdvveqfneandielicrahqlvmegyk

MHHNGQCFTVFSAPNYCDQMNNKGAFITItGDNLTPRFTPFDAVP
.| | .  ||.|||||| .  |. | . .  ..|  .|. |.|..
lhfnekvltvwsapnycyrcgnvaailel.deeldkdfkifeaaa
subfamily_PPP2C_pd Subfamily PPP2C 227-480 9.1e-73 238.0 In-house 41-288 (290) alignment 
Range on Protein: 227-480
Range on HMM: 41-288/290.0
EITVPtgkkFTICGDVHGQFYDLCNIFEINGYPSETNpYLFNGDFVDRGSFSVETIFTMIGFKLLYPNHFFMSRGNHESDVMNKMYGFEGEVKAKYTQ-Q
|. .|     |.||||||||.|| ..| | |   .|| ||| ||.|||| .||||.  .. .|. |..   . ||||||  . ..||| .|.  ||.. .
evkcp....vtvcgdvhgqfhdllelfkiggkspdtn.ylflgdyvdrgyysvetvtllvalkvrykeritilrgnhesrqitqvygfydeclrkygnan

MCDMFTETFCWLPLCHLINEKIFVCHGGLFKEdGVTLEDIRKTDRNRQPPDEGIMCDLLWSDPQPINGRSPSKRGVGCQFGPDVTSKWCETNGIEYVVRS
.  .||. | .|||. |..|.||. ||||  .   ||..||. || .. |.|| .||||||||.  .| . |.|| | .|| |.. |. .|||.....|.
vwkyftdlfdylpltalvdeqifclhgglsps.idtldkiraldrlqevphegplcdllwsdpddrggwgisprgagytfgkdisekfnktngltliara

HEVKPEGYEMHHNGQCFTVFSAPNYCDQMNNKGAFITITgDNLTPRFTPFDAVPH
|..  |||.. |. .  |.||||||| .  |..| . .  |.|. .|  ||. |.
hqlvmegynwshdrnvvtifsapnycyrcgnqaaileld.dklkysflqfdpapr
PPP_4 237-429 9e-71 231.0 In-house 2-197 (197) alignment 
Range on Protein: 237-429
Range on HMM: 2-197/197.0
TICGDVHGQFYDL-CNIFEINGYPSETNPYLFNGDFVDRGSFSVETIFTMIGFKLLYPNHFFMSRGNHESDVMNKMYGFEGEVKAKYTQQMCDMFTETFC
|..||.|||..||  ..... | |||.. |.|.||.||||..|.|.. ... .|| ||..... ||||||  .|..|||. ||. |..... ......|.
tvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvfd

WLPLCHLINEKIFVCHGGLFKEDGvTLEDIRKTDRNRQPP-DEGIMCDL-LWSDPQ-PINGRSPSKRGVGCQFGPDVTSKWCETNGIEYVVRSHEVK
.|||..||.||..|.||||..|   .|..|....|... | .|. ..|| |||||.   .| ..|.||.|. ||||||.| .|.|......||||.|
llplaalidekvlvvhgglsdele.sldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshelk
PPP_2 237-429 6e-70 228.0 In-house 2-198 (198) alignment 
Range on Protein: 237-429
Range on HMM: 2-198/198.0
TICGDVHGQFYDLcNIFEINGYPSETNPYLFNGDFVDRGSFSVETIFTMIGFKLLYPNHFFMSRGNHESDVMNKMYGFEGEVK-AKYTQQMCDMFTETFC
|.|||.|||..|| .|.  || ||... |||.||.||||..|.|...... .|| ||..... ||||||. .||.|||. ||.  |..... ....|.|.
tvcGDlHGqldDL.lilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

WLPLCHLINEKIFVCHGGLFKEDGvTLEDIRKTDRNRQPPDEGIMCDL-----LWSDPQPINGRSPSKRGVGCQFGPDVTSKWCETNGIEYVVRSHEVK
.|||..||.||..|.||||..|   .|..|.|..|... |.|| ..||     |.....  .. ..|.||.|. ||||||.. .|.| .....|.||||
lLplaalidekvlvvHGGlseeik.lldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHevk
PPP_5_Dcr2 237-429 5.5e-69 225.1 In-house 2-199 (199) alignment 
Range on Protein: 237-429
Range on HMM: 2-199/199.0
TICGDVHGQFYDLCNIFEING-YPSETNPYLFNGDFVDRGSFSVETIFTMIGFKLLYPNHFFMSRGNHESDVMNKMYGFEGEVKAK-YTQQMCDMFTETF
|.|||.|||..||  |.. .|  |||.. |.|.||.||||..|.|.. ... .||.||..... |||||.  .|..|||. ||. | . ... ......|
tvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdvf

CWLPLCHLINEKIFVCHGGLFKEDGvTLEDIRKTDRNRQPP-DEGIMCDL-LWSDPQ-PING-RSPSKRGVGCQFGPDVTSKWCETNGIEYVVRSHEVK
.||||..||.||..|.||||..|   ..|...| .|... | ..| ..|| |||||.   .|   .|.||.|. ||||||.|..|.|......||||.|
dwlPlaalidekvlvvhgglspeik.siellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 226-466 4.8e-67 219.4 In-house 31-272 (284) alignment 
Range on Protein: 226-466
Range on HMM: 31-272/284.0
VEITVPtgkkFTICGDVHGQFYDLCNIFEINGYP-----SETNPYLFNGDFVDRGSFSVETIFTMIGFKLLYPNHFFMSRGNHESDVMNKMYGFEGEVKA
.|| .|     .|.||.|||| ||  ....||.|     .. . ||| ||.|||| ||.| |  .. .|||.|.. |. ||||||  .|. |||  | | 
leieap....vkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrgnhesrpvnmqygfyleckk

KYTQQMCDMFTETFCWLPLCHLINEKIFVCHGGLfKEDGVTLEDIRKTDRNRQPPDEGIMCDLLWSDPQ-PINGRSPSKRGVGCQFGPDVTSKWCETNGI
.|.... ..|  .|  .||| ....||.  |||.  || . |... | .|  . || |...|| |.||.  ..|   |.|| |  ||..   .....  .
rysealyeafqlafnamplcavvskkiicmhggi.sedlldlkqldklerpidipdigviadltwadpeaevegykesprgagkvfgakavkeflkkfkl

EYVVRSHEVKPEGYEMHHNGQCFTVFSAPNYCDQMNNKGAFITITGD
. |||.|.|  .|||.  . .  |.|||| || |..| .| ...  .
dlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdee
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 221-473 1e-66 218.2 In-house 42-289 (299) alignment 
Range on Protein: 221-473
Range on HMM: 42-289/299.0
SLPTMVEITVPtgkkFTICGDVHGQFYDLCNIFEINGYPSETNpYLFNGDFVDRGSFSVETIFTMIGFKLLYPNHFFMSRGNHESDVMNKMYGFEGEVKA
| ....|.  |      .|||.|||. ||  ||...|.| ..| .|| ||.||||   .|.|  .. ||. ||..||| |||||   .|..|||  |.. 
sqaslleveap....iivcgdihgqysdllrifdkagfppdvn.flflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecpainrvygfyeecnk

KYTQ-QMCDMFTETFCWLPLCHLINEKIFVCHGGLFKEdGVTLEDIRKTDRNRQPPDEGIMCDLLWSDP-QPINGRSPSKRGVGCQFGPDVTSKWCETNG
.|.  ..  .| ..| ..||. ||. .|.. ||||  .   ||. .|.  | ..||.  .  ||||.|| | . .  .  |||   ||.|| .. ... .
rykstrlwsifqdafaampltgligsrilcmhgglspk.lqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgvsyvfgqdvvadvisrld

IEYVVRSHEVKPEGYEMHHNGQCFTVFSAPNYCDQMNNKGAFITItGDNLTPRFT
|. | |.|.|  .|||.  . .  |.|||| || |..|  | . .  .||   |.
idlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkv.denlvctfv
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 220-463 1.6e-66 217.3 In-house 23-261 (280) alignment 
Range on Protein: 220-463
Range on HMM: 23-261/280.0
KSLPTMVEITVPtgkkFTICGDVHGQFYDLCNIFEINGYPSETNpYLFNGDFVDRGSFSVETIFTMIGFKLLYPNHFFMSRGNHESDVMNKMYGFEGEVK
.   ||||.  |     ..|||.|||. ||  .|.  ..| ..| ||| ||.||||.. .| |  .. .|. |||.|.. |||||   .|. |||  |||
taqatmvevdap....vavcgdlhgqytdllrlfarvsfppdqn.ylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisinrkygfkdevk

AKYTQQMCDMFTETFCWLPLCHLINEKIFVCHGGLFKEdGVTLEDIRKTDRNRQPPDEGIMCDLLWSDPQ-PINGRSPSKRGVGCQFGPDVTSKWCETNG
 .|.... . | | .  |||. |.. .|.. |||| ..  |.|.|...  |  ...|| .  ||||.||.  . | . . |||  .|| .|  . .|   
rryslalynefqelldslplvalvsgrilcmhgglsqk.lvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifganvvkdltekld

IEYVVRSHEVKPEGYEMHHNGQCFTVFSAPNYCDQMNNKGAFITI
|. ..| |.|  .|||.  . .  ||||||.|.....|. | . .
idliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavliv
subfamily_PPP6C_pd Subfamily PPP6C 218-480 8.2e-66 215.1 In-house 26-286 (290) alignment 
Range on Protein: 218-480
Range on HMM: 26-286/290.0
YVKSLPTMVEITVPTGKKFTICGDVHGQFYDLCNIFEINGYPSETNpYLFNGDFVDRGSFSVETIFTMIGFKLLYPNHFFMSRGNHESDVMNKMYGFEGE
.|. |       .|     |.|||.|||||||...|   |   .|. |.| ||||||| .|.||.  .. .|. ||..  . ||||||  . ..|||  |
lvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdts.yvflgdfvdrgyysletftrlltlkakypdritllrgnhesrqitqvygfyde

VKAKYTQQM-CDMFTETFCWLPLCHLINEKIFVCHGGLfKEDGVTLEDIRKTDRNRQPPDEGIMCDLLWSDPQPINGRSPSKRGVGCQFGPDVTSKWCET
 . || .      .|. |  |... .|.|...  |||| . |  ||..||  .|... | .| .|||.||||. ..  . |.|| |  ||  ||......
clnkygnanawkyctkvfdlltiaaiideqvlcvhGgl.spdvktldqirvieraqeiphkgafcdlvwsdpedvetwavsprgagylfgskvtkefvhi

NGIEYVVRSHEVKPEGYEMHHNGQCFTVFSAPNYCDQMNNKGAFITITGDNlTPRFTPFDAVPH
| .. ..|.|..  ||.. . . .  ||.|||||| .  |  . ...  .. . ..  |.|||.
nnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledae.ereaklfkavpd
subfamily_PPP7C_pd Subfamily PPP7C 172-372 3.7e-64 209.8 In-house 2-203 (383) alignment 
Range on Protein: 172-372
Range on HMM: 2-203/383.0
IEDSYDGPRLEDKITKEFVLQLIKTFKNQQKLHKKYAFKMLLEFYNYVKSLPTMVEITVPTGKKFTICGDVHGQFYDLCNIFEINGYPSETNPYLFNGDF
.||||.||||.  .||. | .||..||....|| ||  ..| |  . .|.|| . ...  . |. |.|||.||.. ||. |.  ||.||| |||.|||||
vedsytgprlslpltkdeveklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdf

VDRGSFSVETIFTMIGFKLLYPNHFFMSRGNHESDVMNKMYGFEGEVKAKY---TQQMCDMFTETFCWLPLCHLINEKIFVCHGGLFkeDGVTLEDIRKT
||||. ||| .. .. . |.||..... |||||  ..|  |||  ||. ||   ....  .. . |.||||. ||.|||...|||.   |   || . | 
vdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGis..dktdlelldki

DRNR
.|..
ersk
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 210-463 3.5e-63 206.6 In-house 30-281 (297) alignment 
Range on Protein: 210-463
Range on HMM: 30-281/297.0
KMLLEFYNYVKSLPTMVEITVPtgkkFTICGDVHGQFYDLCNIFEINGYPSETNpYLFNGDFVDRGSFSVETIFTMIGFKLLYPNHFFMSRGNHESDVMN
|.|    . .|.  .|||.  |      .|||.|||| ||  .|   |.|  .| ||| ||.|||| ||.|||  .. .|. .|  .|. ||||| ...|
klldlaldvfkaqksmvevnap....ikvcgdihgqfpdllrlfhrggwpptan.ylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecefvn

KMYGFEGEVKAKYT-QQMCDMFTETFCWLPLCHLINEKIFVCHGGLFK--EDGVTLEDIRKTDRNRQpPDEGIMCDLLWSDPQ-PINGRSPSKRGVGCQF
|.|||  |.. .|   .|   | . | ||||. || .||.. ||||     . .||. .|| .|...   |....||||.||   . |    .|| || |
kvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierste.gkerlvadllwadpisglsgfmenqrgagcgf

GPDVTSKWCETNGIEYVVRSHEVKPEGYEMHHNGQCFTVFSAPNYCDQMNNKGAFITI
| |   | |    .. |.|.|.|  .|||.    .  |.|||| || |..|  ||.. 
grdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmsc
subfamily_PPG1_pd Subfamily PPG1 236-479 3.3e-61 200.1 In-house 43-297 (300) alignment 
Range on Protein: 236-479
Range on HMM: 43-297/300.0
FTICGDVHGQFYDLCNIFEINGYPSETNpYLFNGDFVDRGSFSVETIFTMIGFKLLYPNHFFMSRGNHESDVMNKMYGFEGEVKAKY--TQQMCDMFTET
 |. |||||||||. .||.| |   .|| ||| ||.|||| .|||||  .| .|| ||    . ||||||  . ..||| .|.  ||   ... . .|| 
vtvvgdvhgqfydvleifkiggqvpdtn.ylflgdyvdrglysvetisllivlklrypsritllrgnhesrqitqvygfyteclrkyggnsrvwkyltei

FCWLPLCHLINEKIFVCHGGLFKeDGVTLEDIRKTDRNRQPPDEGIMCDLLWSDPQ---------PIN-G--RSPSKRGVGCQFGPDVTSKWCETNGIEY
| .| |. .|.|.|.. ||||   .  ....|.  || |. |.|| ..|||||||.         | . |     |.|| |  .| ||. |. ..| .. 
fdylvlaaiideeiycvhgglsp.svlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqhfvvsqrgagysygkdvvekflrnndmnr

VVRSHEVKPEGYEMHHNGQCFTVFSAPNYCDQMNNKGAFITITgDNLTPRFTPFDAVP
..|.|..  |||... ...  ||.|||||| .  || . . .  ...   |  ... |
iirahqlcnegyqilfdnklstvwsapnycyrcgnkasilely.ekderyfnvyeeap
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 203-464 4.3e-61 199.3 In-house 10-269 (287) alignment 
Range on Protein: 203-464
Range on HMM: 10-269/287.0
LHKKYAFKMLLEFYNYVKSLPTMVEITVPtgkkFTICGDVHGQFYDLCNIFEINGYPSETNpYLFNGDFVDRGSFSVETIFTMIGFKLLYPNHFFMSRGN
.  |  ...| .  . .. ||...|.. |     ||.||.|||. || .||.  |...... ||| ||.||||. |.| .. .  .|..||..  . |||
fsdkdilevlekieeileplpalleveap....itivGdihGqlddllrifnavGaapkvq.ylflGdyvdrGakslevslllfslkiaypkkvhllrGn

HESDVMNKMYGFEGEVKAKYTQQMCDMFTETFCWLPLCHLINEKIFVCHGGLFKEdGVTLEDIRKTDRNRQPP--DEGIMCDLLWSDPQ-PINGRSPSK-
||   .||.|||. |.| |. ...   | . |  ||||  ....|.  |||. ..   .|....   . ..|   |||.. ||||.||.   ..  . | 
hevkkinklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispk.lksldslkalkkpttplacdeglqvdllwadpekdaktfelnki

RGVGCQFGPDVTSKWCETNGIEYVVRSHEVKPEGYEMHHNGQCFTVFSAPNYCDQMNNKGAFITIT
|..   ||  .  . ... .|. .||.|||. |||..  . .. |||||| |. .  | || ....
raisvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvs
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 263-465 1.9e-59 194.4 In-house 101-303 (317) alignment 
Range on Protein: 263-465
Range on HMM: 101-303/317.0
NPYLFNGDFVDRGSFSVETIFTMIGFKLLYPNHFFMSRGNHESDVMNKMYGFEGEVKAKYTQQMCDMFTETFCWLPLCHLINEKIFVCHGGLfKEDGVTL
. ||| ||.|||| ||.| .  .. .|||||.. |. ||||||  .|. |||  ||| .| ... ..|  .|  |||| ..|.||.  |||.  |. . |
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGi.seelldl

EDIRKTDRNRQPPDEGIMCDLLWSDPQP-INGRSPSKRGVGCQFGPDVTSKWCETNGIEYVVRSHEVKPEGYEMHHNGQCFTVFSAPNYCDQMNNKGAFI
. . | .|  . || |...|| |.||.. ..|  .|.|| |  ||..   .....  .. |||.|.|  .|||.  . .  |.||||.|| |..| .| .
kqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavl

TITG
..  
svdk
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 212-464 2.5e-58 190.8 In-house 12-261 (284) alignment 
Range on Protein: 212-464
Range on HMM: 12-261/284.0
LLEFYNYVKSLPTMVEITVPtgkkFTICGDVHGQFYDLCNIFEINGYPSETNpYLFNGDFVDRGSFSVETIFTMIGFKLLYPNHFFMSRGNHESDVMNKM
|.. .. ..  | ..|.  |      ||||.|||| ||  .|. ||.|  .| ||| ||.||||   .|||. .. .|...|||||| |||||  ..||.
lfhafsifnkqpmlievnsp....inicgdihgqfsdllrlfdkngfphran.ylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinki

YGFEGEVKAKYTQQ-MCDMFTETFCWLPLCHLINEKIFVCHGGLFKEDGvTLEDIRKTDRNRQPP-DEGIMCDLLWSDPQPI-NGRSPSKRGVGCQFGPD
|||  |.. .| .  .   |   |  .||  |. ..|.. |||. |     . ..|   |  . |  . .  |.|||||  . .|  |  |||   || |
ygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlq.nvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsd

VTSKWCETNGIEYVVRSHEVKPEGYEMHHNGQCFTVFSAPNYCDQMNNKGAFITIT
   |  .   |. |||.|.|  .|||.  | .  |.|||| || |..|  | . . 
alrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvn
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 236-464 6.7e-58 189.1 In-house 37-264 (281) alignment 
Range on Protein: 236-464
Range on HMM: 37-264/281.0
FTICGDVHGQFYDLCNIFEINGYPSETNpYLFNGDFVDRGSFSVETIFTMIGFKLLYPNHFFMSRGNHESDVMNKMYGFEGEVKAKYTQQMCDMFTETFC
 .. ||.|.|| || ..||. | ..|.  ..| ||.||||  |.|... .. .|. |... .. |||||   .||.|||  | . || ...   | . | 
ivvvGdlhaqfndlkrlfellgrvpeev.lvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvnkiygfyvecvtkyGeelwalfqrcfn

WLPLCHLINEKIFVCHGGLFKEdGVTLEDIRKTDRNRQPPDEGIMCDLLWSDPQP-INGRSPSKRGVGCQFGPDVTSKWCETNGIEYVVRSHEVKPEGYE
 ||.  ||.... . ||||  |  ..|...|.  .  ...| |.. ||||.||..  ..   | ||..  || .|  . | . ..|...|.| |  .|||
rlpisaliakrvlcmhGGlsPe.ltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfGknvvddvckrleveliirahqvvqdGye

MHHNGQCFTVFSAPNYCDQMNNKGAFITIT
.    .  ||||.||||.. .| .| ... 
vlsgrklitvfsvpnycafyknaaavlkvd
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 201-464 3.2e-56 183.5 In-house 14-276 (290) alignment 
Range on Protein: 201-464
Range on HMM: 14-276/290.0
QKLHKKYAFKMLLEFYNYVKSLPTMVEITVPtgkkFTICGDVHGQFYDLCNIFEINGYPSETNpYLFNGDFVDRGSFSVETIFTMIGFKLLYPNHFFMSR
. .  |  ...| .  . .. ||...|.  |     .| ||.|||. .| . |.  ||| . . .|| ||.||||. |.|    .. .|..|...  . |
dafsdkdileilekieeileplpalleveap....ivivgdihgqldallryfdavgyppkvk.flflgdyvdrgakslevslllfcykiryskkvhllr

GNHESDVMNKMYGFEGEVKAKYTQQMCDMFTETFCWLPLCHLINEKIFVCHGGLFKED--GVTLEDIRKTdRNRQPPDEGIMCDLLWSDPQP--INGR-S
||||   .|..|||  |.  | . ..  .. . |  |.||  ...||.  |||. ..     .|. ..|  | .   |||.. ||||.||.    .    
gnhevrkvnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkp.rvpltcdeglqvdllwadptrdkddtial

PSKRGVGCQFGPDVTSKWCETNGIEYVVRSHEVKPEGYEMHHNGQCFTVFSAPNYCDQMNNKGAFITIT
  .|..   || ..  ..... ... .||.|||| ||...  . .. |||||| |. .  | || .|..
nkqraisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvs
subfamily_PPZ_pd Subfamily PPZ 221-466 3.1e-54 177.5 In-house 43-283 (300) alignment 
Range on Protein: 221-466
Range on HMM: 43-283/300.0
SLPTMVEITVPtgkkFTICGDVHGQFYDLCNIFEINGYPSETNpYLFNGDFVDRGSFSVETIFTMIGFKLLYPNHFFMSRGNHESDVMNKMYGFEGEVKA
. |...|.. .      | ||||||. ||  .|   |.|  .| ||| ||.||||  |.|||. .. .|. ||. ||. |||||   . ..|||  |.| 
aqpallelsps....vkivgdvhgqyadllrlftkcgfppsan.ylflgdyvdrgkqsletillllcykikypenffllrgnhecanvtrvygfydeckr

KYTQQMCDMFTETFCWLPLCHLINEKIFVCHGGLFKEdGVTLEDIRKTDRNRQPPDEGIMCDLLWSDPQP-INGRSPSKRGVGCQFGPDVTSKWCETNGI
.   ..   | .||  |||. ..  |||. ||||      ....||.  |  . || |.. |||||||    |     .|||   .      |. .  |.
rcnikiwktfvdtfntlplaaivagkifcvhgglspv.lnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvsycynkvainkflnkfgf

EYVVRSHEVKPEGYEMHHNGQCFTVFSAPNYCDQMNNKGAFITITGD
. |.|.| |  .|||.  .    ||||||||| ...| || ....  
dlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvseg
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 237-469 7.2e-48 156.4 In-house 36-266 (280) alignment 
Range on Protein: 237-469
Range on HMM: 36-266/280.0
TICGDVHGQFYDLCNIFEINGYPSETNpYLFNGDFVDRGSFSVETIFTMIGFKLLYPNHFFMSRGNHESDVMNKMYGFEGEVKAKYTQQMCDMFTETFCW
 . ||.| |. |.  .|.. |   | .  .| ||.||||   .| .  .. .|. | .. .. |||||.  .||.|||  |.. ||   .   |   |  
kvigdihaqyqdmnrlfdligrvpeek.lmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiygfyvecqykygvglwwdfqscfnr

LPLCHLINEKIFVCHGGLFKEdGVTLEDIRKTDRNRQPPDEGIMCDLLWSDPQP-INGRSPSKRGVGCQFGPDVTSKWCETNGIEYVVRSHEVKPEGYEM
.|.. ||...... ||||  |  . |. ||.  |  .| | |.. |||||||    .|   | ||.   ||  |  . |..  |. ..|.|.|  .||||
mpmsgliskrvlcmhgglspe.linldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkgvveqacksleidliirahqvvqdgyem

HHNGQCFTVFSAPNYCDQMNNKGAFITITgDNLT
    .  |||| |||| |. |  | . .   || 
magrrlitvfsvpnycaqftnaaavvcln.anlq
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 264-463 2e-46 151.7 In-house 121-320 (339) alignment 
Range on Protein: 264-463
Range on HMM: 121-320/339.0
PYLFNGDFVDRGSFSVETIFTMIGFKLLYPNHFFMSRGNHESDVMNKMYGFEGEVKAKYTQQMCDMFTETFCWLPLCHLINEKIFVCHGGLfKEDGVTLE
 ||| ||.|||| ||.| .  .  .|| ||.. .. ||||||  .|  |||  ||. .|  |. . | . |  .|.| .||. |.. |||.  |   ...
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggi.sehltsfn

DIRKTDRNRQPPDEGIMCDLLWSDPQPIN-GRSPSKRGVGCQFGPDVTSKWCETNGIEYVVRSHEVKPEGYEMHHNGQCFTVFSAPNYCDQMNNKGAFIT
..    |  . || |.. || |.||.| . |  || ||    |||     . .   .. |.| |.|  .|||.    .  |.||||||| | .|  | ..
qfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfs

I
|
i
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 223-463 7.2e-46 149.8 In-house 40-278 (307) alignment 
Range on Protein: 223-463
Range on HMM: 40-278/307.0
PTMVEITVPTgkkfTICGDVHGQFYDLCNIFEINGYPSETNpYLFNGDFVDRGSFSVETIFTMIGFKLLYPNHFFMSRGNHESDVMNKMYGFEGEVK---
 ..|.|  |      . ||.|||| || |.| . | | ||  |.| ||.|||| .|.|.|. .. .|. ||..  . |||||   .|| |||  |.    
kalvdidppc....vvvgdlhgqfndlinmfillgrppetv.yvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygfyeecvtsi

AKYTQQMCDMFTETFCWLPLCHLINEKIFVCHGGLFKeDGVTLEDIRKTDRNRQPPDEGIMCDLLWSDPQPI-NGRSPSKRGVGCQFGPDVTSKWCETNG
 |  ...  .|   |  ||.  ||  ||.. ||||       |...|.  .  . |  ||. |.||.||.|       | || |  || .|    |   |
pkcgeeiwalfqrcfnnlpisaliatkilcmhgglsp.altcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgtnviddvckrlg

IEYVVRSHEVKPEGYEMHHNGQCFTVFSAPNYCDQMNNKGAFITI
.| ..|.|..  .|| .    .  |.|||| ||.  .| |. . .
veliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkv
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 200-466 1.1e-43 142.6 In-house 3-289 (302) alignment 
Range on Protein: 200-466
Range on HMM: 3-289/302.0
QQKLHKKYAFKMLLEFYNYVKSLPTMVEITVPTgkkfTICGDVHGQFYDLCNIFEIN----------GYPSETNPYLFNGDFVDRGSFSVETIFTMIGFK
.....|.  .... .  . .|   |..||. |     || ||.|||| ||  |.  .           |   .. ..| ||.||||| |.| |  .  .|
kkeysksellllieaviellkkektlaeispPv....tivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalk

LLYPNHFFMSRGNHESDVMNKMYGFEGEVKAKYTQ----QMCDMFTETFCWLPLCHLINEKIFVCHGGLFkEDGVTLEDIRKTDRNRQP-PDEGIMCDLL
.|||... . |||||.  .|  |||..|.. ....    .. . | |.|...||  |. |||.  |||.  .   .||||.| .|  .   .. .  |||
vlyptnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggis.pklesledikkikrplkevtedslaqdll

WSDPQPING-----RSP-----SKRGVGCQFGPDVTSKWCETNGIEYVVRSHEVKPEGYEMHHNGQCFTVFSAPNYCDQMNNKGAFITITGD
..||  ...     . |      .||.   |      . |.  ... .||.| . |||. .. . .  |.||||.| ....|||| . . ..
fadpldvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtn
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 200-466 1.2e-43 142.4 In-house 4-290 (302) alignment 
Range on Protein: 200-466
Range on HMM: 4-290/302.0
QQKLHKKYAFKMLLEFYNYVKSLPTMVEITVPTgkkfTICGDVHGQFYDLCNIFEIN----------GYPSETNPYLFNGDFVDRGSFSVETIFTMIGFK
.....|.  .... .  . .|   |..||. |     || ||.|||| ||  |.  .           |   .. ..| ||.||||| |.| |  .  .|
kkeysksellllieaviellkkektlaeispPv....tivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalk

LLYPNHFFMSRGNHESDVMNKMYGFEGEVKAKYTQ----QMCDMFTETFCWLPLCHLINEKIFVCHGGLFkEDGVTLEDIRKTDRNRQP-PDEGIMCDLL
.|||... . |||||.  .|  |||..|.. ....    .. . | |.|...||  |. |||.  |||.  .   .||||.| .|  .   .. .  |||
vlyptnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggis.pklesledikkikrplkevtedslaqdll

WSDPQPING-----RSP-----SKRGVGCQFGPDVTSKWCETNGIEYVVRSHEVKPEGYEMHHNGQCFTVFSAPNYCDQMNNKGAFITITGD
..||  ...     . |      .||.   |      . |.  ... .||.| . |||. .. . .  |.||||.| ....|||| . . ..
fadpldvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtn
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 236-462 9.8e-41 133.1 In-house 9-241 (263) alignment 
Range on Protein: 236-462
Range on HMM: 9-241/263.0
FTICGDVHGQFYDLCNIFEINGYPSETNpYLFNGDFVDRGSFSVETIFTMIGFKLLYPNHFFMSRGNHESDVMNKMYGFEGEVKAKYTQQ-----MCDMF
  |||| |||. ||  ||.  |  ..|. ||| ||.|||| .|.| |. .. .||  | .... |||||   .|| |||  |.| .. ..     . . |
inicgdthgqyndllrifnacgaatktq.ylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesvynhf

TETFCWLPLCHLINEKIFVCHGGLFKeDGVTLEDIRKTDRNRQP-PDEGIMCDLLWSDPQ-PINGRSPSK-RGVGCQFGPDVTSKWCETNGIEYVVRSHE
 . | ..||| .....|.. |||.      .|.|||      .      . |||||.||.   .|  | | | .   ||       |.   |. .||.|.
nqvfsymplcaivskrilcmhggisp.hlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidlivrahq

VKPEGYEMHHNGQCFTVFSAPNYCDQMNNKGAFIT
|   || .  . .  |||||  |  .. |  | . 
vveygyaffadrrlitvfsasryqielcnyaavvv
Metallophos Calcineurin-like phosphoesterase 235-430 2e-39 128.9 Pfam-A 2-200 (200) alignment 
Range on Protein: 235-430
Range on HMM: 2-200/200.0
KFTICGDVHGQFYDL---CNIFEINGYPSETNPYLFNGDFVDRGSFSVETIFTM--IGFKLLYPNHFFMSRGNHESDVMNKMYGFEGEVK----------
.....||.||...||    .|.. .. ... ...||.||.||||  | ||.  .     |||.|...|. ||||||| .|. |||  |.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------AKYTQQMCDMFTETFCWLPLCHLINEKIFVCHGGLFKEDGVTLEDirktdrnrqppdegimcdllwsdpqpingrs
                         ...    ... |.|..|||..|.. ||...||.|....| ..                                 
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

pskrgVGCQFGPDVTSKWCETNGIEYVVRSHEVKP
      .. ||||...|..| .|. .|.|.|. ||
.....gselfgpdalekllekygvdlvlrGHtHkp
subfamily_PPPLV_pd Subfamily PPPLV 237-464 4.9e-38 124.1 In-house 27-276 (290) alignment 
Range on Protein: 237-464
Range on HMM: 27-276/290.0
TICGDVHGQFYDLCN---IFEINGYPSETNPYLFNGDFVDRGSFSVETIFTMIGFKLLYPNHFFMSRGNHESDVMNKMYGFEGEVKAKYTQQMCD---MF
 . ||.||.. ||      .   |       .|| ||.|||| |||| |  ..  |.||| .... ||||| . . . . . || . |. ... .    |
yvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqesieykgegsfkfgdsleevweaf

TETFCWLPLCHLINEKIFVCHGGLFKED--GVTLEDIRKTD-RNRQPPDEG-IMCDLLWSDPQPIN-----GR--------SPSKRGVGCQFGPDVTSKW
...| .|||   |..|.| .|.|. .    .  .  |..   | ... |   .  |.|||||.  .     |.        . ..|| |. |. |   ..
nnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvlneGfvdndrrGtghvfsedaleaf

CETNGIEYVVRSHEVKPEGYEMHHNGQCFTVFSAPNYCDQMNnKGAFITIT
 . |....|.|.|||| .|... ..|.  ||||. .|| . | . | | . 
lkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssn.eaalilvd
PPP5 PPP5 TPR repeat region 135-228 6.1e-34 106.4 Pfam-A 1-95 (95) alignment 
Range on Protein: 135-228
Range on HMM: 1-95/95.0
KFDECSKIVRRQKFEAAISTDHDKKTVAETLDINAMAIEDSYDGPRLE-DKITKEFVLQLIKTFKNQQKLHKKYAFKMLLEFYNYVKSLPTMVEI
|. ||.|.|....||.||..|..|..|||..||. ..|||.||||||| .|.|.||| .|...||.|.|||||.....||.  ...|.||..|||
KlkeCeklvkkiaFekAIevdeekrsvaesidiesieieddYdgprledekvtlefvkelleefkkqkklhkkfvyqilldvkellkklpslvei
subfamily_PPP7C_pd Subfamily PPP7C 380-476 7.6e-31 100.2 In-house 237-333 (383) alignment 
Range on Protein: 380-476
Range on HMM: 237-333/383.0
MCDLLWSDPQPINGRSPS-KRGVGCQFGPDVTSKWCETNGIEYVVRSHEVKPEGYEMHHNGQCFTVFSAPNYCDQMNNKGAFITItGDNLTPRFTPFD
. |.|||||.  .|  |   || |. ||||||.|  .  ......|||| ||||||. |. .. |.||| || ..  |.||.. . |..||||.  . 
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvkl.gkdltprivqyq
TPR_11 TPR repeat 32-93 9.9e-15 43.6 Pfam-A 6-69 (69) alignment 
Range on Protein: 32-93
Range on HMM: 6-69/69.0
IKDEANQFFKDQVYDVAADLYSVAIEIHP-TAVLYGNRAQAYLKKE-LYGSALEDADNAIAIDP
 | ..|..|| . || | ..|. |.|. | .|.|| |.|.||||.   | .||||.. |...||
lkelGnalfkegdydeAieayekAleldpnnaelyynlAlaylklgkdyeeAledyekAleldP
TPR_11 TPR repeat 79-127 7.2e-11 31.2 Pfam-A 20-69 (69) alignment 
Range on Protein: 79-127
Range on HMM: 20-69/69.0
GSALEDADNAIAIDPSYVKGFYRRATANMALG-RFKKALTDYQAVVKVCP
  |.|  ..|...||.. . .|..| | . || ....||.||. ...  |
deAieayekAleldpnnaelyynlAlaylklgkdyeeAledyekAleldP
TPR_9 Tetratricopeptide repeat 70-133 2.2e-10 29.7 Pfam-A 3-66 (73) alignment 
Range on Protein: 70-133
Range on HMM: 3-66/73.0
QAYLKKELYGSALEDADNAIAIDPSYVKGFYRRATANMALGRFKKALTDYQAVVKVCPNDKDAR
..||  | . .||. ..  ....|  .   . |. . . ||..  ||.|..| ...||.. ||.
aiylreedferALavverllllaPddpyerRDrGlllaqlgclaaAledLeaflelcpdapdae
TPR_1 Tetratricopeptide repeat 97-129 8.9e-09 24.4 Pfam-A 2-34 (34) alignment 
Range on Protein: 97-129
Range on HMM: 2-34/34.0
KGFYRRATANMALGRFKKALTDYQAVVKVCPND
| .|... | . ||....|| .|. .... ||.
kalynlGnaylklgkydeAleyyekALelnPnn
TPR_1 Tetratricopeptide repeat 62-95 5.8e-08 21.8 Pfam-A 1-34 (34) alignment 
Range on Protein: 62-95
Range on HMM: 1-34/34.0
AVLYGNRAQAYLKKELYGSALEDADNAIAIDPSY
|  . |...||||.. |  |||. . |. ..|..
akalynlGnaylklgkydeAleyyekALelnPnn
TPR_2 Tetratricopeptide repeat 97-129 7.3e-08 21.7 Pfam-A 2-34 (34) alignment 
Range on Protein: 97-129
Range on HMM: 2-34/34.0
KGFYRRATANMALGRFKKALTDYQAVVKVCPND
.. |... | ..||....|| ... ... .||.
ealynlGlayyklgdyeeAleafekAleldPnn
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 236-260 8.1e-08 24.8 In-house 38-62 (317) alignment 
Range on Protein: 236-260
Range on HMM: 38-62/317.0
FTICGDVHGQFYDLCNIFEINGYPS
 ||.||.|||| ||  ....||.| 
vtivGdihGqfedllalldlnGwpl
TPR_16 Tetratricopeptide repeat 68-129 5.4e-07 19.8 Pfam-A 3-64 (65) alignment 
Range on Protein: 68-129
Range on HMM: 3-64/65.0
RAQAYLKKELYGSALEDADNAIAIDPSYVKGFYRRATANMALGRFKKALTDYQAVVKVCPND
.|.|.|.   |  ||. .. |.| .| ..  ....| | ...||...|.  ..| ..  |.|
lArallraGdydeAlaaleaalalaPeaaeallllaeallrqgrldaAaallraalalaPdd
subfamily_YNL217W_pd Subfamily YNL217W 232-345 2.5e-06 20.1 In-house 8-105 (235) alignment 
Range on Protein: 232-345
Range on HMM: 8-105/235.0
TGKKFTICGDVHGQFYDLCNIFE-INGYPSETNPYLFNGDFVDRGSFSVETIFTMigfkllYPNHFFMSRGNHESDVMNKMygfegeVKAKYTQQMCDM-
.||.. . ||||| . .| ....  .|   |    .. ||....|  |||..  .        ..    .||||  |. ..         |  . . .  
lgkrllvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllay......kwvkkpkgaeple

FTETFCWLPlchlinE
|.. | .|.       
fsskfsfle......s
Intein_splicing Intein splicing domain 149-217 2.8e-06 12.7 Pfam-A 201-269 (323) alignment 
Range on Protein: 149-217
Range on HMM: 201-269/323.0
EAAISTDHDKKTVAETLDINAMAIEDSYDGPRLEDKITKEFVLQLIKTFKNQQKLHKKYAFKMLLEFYN
. .. .. ||.   | .  .    .  |    |  |. |||||  .|..|| .    .| ..   |  .
ndlvavakdkqekleaiknkikglnaryisivltkkeikefvlvqlkilknadnytadykiekireela