Gene ppm-1 in Caenorhabditis elegans

Synonym: CELE_F25D1.1, ppm-1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1A
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP156_AA protein Get Run
CeleP156_AA_85-382 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1A_pd Subfamily PPM1A 95-382 8.5e-113 369.4 In-house 2-281 (282) alignment 
Range on Protein: 95-382
Range on HMM: 2-281/282.0
KTNVHGEGNGIRYGMSSMQGWRICMEDSHIaeAIMSQSsPYKDWSFFAVFDGHAGHHIANRASSQLLEHLISSEEFREmtktleennGVLTDSTLKLLEK
| . ..||||.|||.|||||||..|||.|.  ...| .  .||||||||||||||...|. ....|||.....||..|           |..|. . ...
kpksqaegnglrygvssmqgwrvemEDaht..vvaslg.alkdwsfFavfDGHaGsevakyvkkhllenileeeelke.........aaleasekdevke

GIKKGFLSFDEISKTSNDIS----KSGCTAVCAIVTPTHFIIGNLGDSRAVVAGK-NEIFGTEDHKPYLEKERKRIEGAGGSVMIQRINGSLAVSRAFGD
....|||..||  ..... .    |||.|||...|...|.|| ||||||||.. . ...| ||||||. .||.|||| |||||...|.||.||||||.||
alrqgfLaldeairelstdlktadksGsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGD

YEYKDDPRLPADQQLVSPEPDVYIRERNLENDqFMVVACDGIYDVMTNEELAEFVKDRLSVHSDLREVCDDVLDECLVKGSRDNMTMVVVCFP
||||......|..||||.||.|.. ||. |.| |.|.|||||.||...||..|.|..||.|...|.||.....|..| ||||||....||.|.
yeykeeeekkaeeqlvsaepevtsierseedd.flvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsrDNlsvlvvlfa
PPM_PTC7 106-374 7.6e-90 293.8 In-house 2-259 (259) alignment 
Range on Protein: 106-374
Range on HMM: 2-259/259.0
RYGMSSMQGWRICMEDSHIAEAIMSQSSPYKDWSFFAVFDGHAGHHIANRASSQLLEHLISSEEFREMTktleenngvltdstlkLLEKGIKKGFLS--F
..|.|..||.| .|||.|||.| ...||......||||||||.|...|. |...| |.| ....|.|..                .|||...|.||.  .
dggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeele................klekalrksflaldt

DEISKTSND---ISKSGCTAVCAIVTPTHFIIGNLGDSRAVVAGKNEIF--GTEDHKPYLEKERKRIEGAGGSVM---IQRINGSLAVSRAFGDYEYKDD
|| .|.|..    |.||.|||.|..|...... |.||||||........   ||||||..|.||.|||||||||.    .|.||.|||||||||.|.|..
deelksseantepstsGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpk

PRlpaDQQLVSPEPDVYIRERNLEnDQFMVVACDGIYDVMTNEELAEFVKDRLSVHsDLREVCDDVLDECLVKGSRDNM
..   ..||||.|||.. .... | |.|...|.||..||....|....|...|| . |..|......||.. .||.||.
et...eeqlvsaePdisstkidee.defliLasdGlwdvvsdqeavdlvrselskk.dpmeaaeklvdeaiargsedni
PP2C Protein phosphatase 2C 106-374 1.9e-89 292.6 Pfam-A 2-255 (255) alignment 
Range on Protein: 106-374
Range on HMM: 2-255/255.0
RYGMSSMQGWRICMEDSHIAEAIMSQSSPYKDWSFFAVFDGHAGHHIANRASSQLLEHLISSEEFREMTktleenngvltdstlkLLEKGIKKGFLS-FD
..|.|..||.| .|||.|||.. ...||......||||||||.|...|. |...| |.| ....|.|..                ..||...|.||. .|
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele................kvekalrksfladtd

EISKTSND---ISKSGCTAVCAIVTPTHFIIGNLGDSRAVVAGKNEIF--GTEDHKPYLEKERKRIEGAGGSVM-IQRINGSLAVSRAFGDYEYKDDPrl
|  |.|..    ||||.|||.|......... |.||||||.. |....   ||||||. |.||.|||.|||||. ..|.|||||||||.||.|.|...  
eelksskantepsksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke..

padQQLVSPEPDVYIRERNLEnDQFMVVACDGIYDVMTNEELAEFVKDRLSVHSDLREVCDDVLDECLVKGSRDNM
   .||||.||||. .... | |.|...|.||..||....|....|...|| .....|......||.. .||.||.
...eqlvsaePdvtsvkltee.defliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PP2C Protein phosphatase 2C 106-374 1.9e-89 292.6 In-house 2-255 (255) alignment 
Range on Protein: 106-374
Range on HMM: 2-255/255.0
RYGMSSMQGWRICMEDSHIAEAIMSQSSPYKDWSFFAVFDGHAGHHIANRASSQLLEHLISSEEFREMTktleenngvltdstlkLLEKGIKKGFLS-FD
..|.|..||.| .|||.|||.. ...||......||||||||.|...|. |...| |.| ....|.|..                ..||...|.||. .|
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele................kvekalrksfladtd

EISKTSND---ISKSGCTAVCAIVTPTHFIIGNLGDSRAVVAGKNEIF--GTEDHKPYLEKERKRIEGAGGSVM-IQRINGSLAVSRAFGDYEYKDDPrl
|  |.|..    ||||.|||.|......... |.||||||.. |....   ||||||. |.||.|||.|||||. ..|.|||||||||.||.|.|...  
eelksskantepsksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke..

padQQLVSPEPDVYIRERNLEnDQFMVVACDGIYDVMTNEELAEFVKDRLSVHSDLREVCDDVLDECLVKGSRDNM
   .||||.||||. .... | |.|...|.||..||....|....|...|| .....|......||.. .||.||.
...eqlvsaePdvtsvkltee.defliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
subfamily_PPM1G2_pd Subfamily PPM1G2 88-381 3.7e-76 248.8 In-house 2-286 (287) alignment 
Range on Protein: 88-381
Range on HMM: 2-286/287.0
LDKPKTDKTNVHGEGNGIRYGMSSMQGWRICMEDSHIAEAIMSQSSPYKDWSFFAVFDGHAGHHIANRASSQLLEHLISseefremtktleenngvLTDS
|..| ..| .  .. . .. | |.|||.|. |||.|| |  . . |  |. ..||||||| |...|. |...| . . .                  .. 
lsepvvakesascanaltkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiak.................kksf

TLKLLEKGIKKGFLSFDEISKTS---NDiSKSGCTAVCAIVTPTHFIIGNLGDSRAVVAGKNEIFG-TEDHKPYLEKERKRIEGAGGSVMIQRINGSLAV
.   ||. .|..||..||        .| ...|.||| .... ......| ||||||.. | ..   . ||||  |.|.|||. ||| | ..|.||.||.
kegaleqilkdafletDeellkdeklkd.esaGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfvelnrvngnLal

SRAFGDYEYKDDPRLPADQQLVSPEPDVYIRERNlENDQFMVVACDGIYDVMTNEELAEFVKDRLSVHSDLREVCDDVLDECLVKGSR------DNMTMV
|||.||.|.|.  ......|.|  .||| ..... |.| |.|.|||||.||.||.|. ..|. ||. . .| |.....||.|| . |.      ||||.|
sralgDfefkknvkkkpeeqivtavPDvlvkkld.eddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvv

VVCF
.|..
ivvl
0034914 PP2C-like 86-382 5.8e-75 244.7 In-house 2-291 (295) alignment 
Range on Protein: 86-382
Range on HMM: 2-291/295.0
AFLDKPKTDKTNVHGEGNGIRYGMSSMQGWRICMEDSHIAEAimSQSSPYKDWSFFAVFDGHAGHHIANRASSQLLEHLISSEEFREM----Tktleenn
..|..|........ . . .|.|..|.||.|  .||....    .  |  .|...|.||||| ||..|. ||. |.|.|..  |   .    .       
lllslpllellllsslllllrvgvasdqGrrksneDavlvvl..nllslledlllfgvfDGhgGhaaaevasellvelllellekllllltls.......

gvltdstLKLLEKGIKKGFLSFDE----ISKTSNDISKSGCTAVCAIVTPTHFIIGNLGDSRAVVAGKNE-IFGTEDHKPYLEKERKRIEGAGGSVMIQR
       |  .|. ..|.||. ||     .  ... . ||.|||.|..........|.||||||.  ..| .. |.||||. | ||.||. ||| |.  |
.......ledieealrkaflaadeellelallrpelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavshgr

INGSLAVSRAFGDYEYKDDPRLPADQQLVSPEPDVYIRERNLENDQFMVVACDGIYDVMTNEELAEFVKDRLSVHSDLREVCDDVLDECLVKGSRDNMTM
.||.|||.||.||...|  ..|.. ..|||.||||...|..||.|.|...|.||..||..|||....|...|. . || |... ..|..| .|||||.| 
vngvlavtRalGdfdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTv

VVVCFP
|||...
vvvrln
PP2Cc_SM00332 97-379 8.7e-75 244.6 In-house 2-274 (274) alignment 
Range on Protein: 97-379
Range on HMM: 2-274/274.0
NVHGEGNGIRYGMSSMQGWRICMEDSHIAEAIMSqssPYKDWSFFAVFDGHAGHHIANRASSQLLEHLISSEEFREMTKtleenngvltdstLKLLEKGI
...|...|..||.|||||||  ||| |.    ..   . .||.||.|||||.|. .|. .|..| |.|... .. . ..              .  |. .
sesgsnlglsygkssmqgwrksmeDahvvvvdlv...eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdel.............eddveeal

KKGFLSFDEISKTSNDI-----SKSGCTAVCAIVTPTHFIIGNLGDSRAVVAGKNE-IFGTEDHKPYLEKERKRIEGAGGSVMIQRINGSLAVSRAFGDY
||.|||.||   ....      ..||.|||.|...  .... |.||||||.. ... .  ..||||  |.|||||. |||.|. .|.||.|||||||||.
kkaflstdeeileeeqskelenalsGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdh

EYKDDPrlPADQQLVSPEPDVYIRERnLENDQFMVVACDGIYDVMTNEELAEFVKDRL--SVHSDLREVCDDVLDECLVK-GSRDNMTMVVV
..|.    .  .. ...||||.. .   ..|.|...|.||..||..|.|. ..|...|   .. |  |..... .|.. . ||.||.|.|||
flkknk..klkepyitaepdvkvvtl.tsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv
0049733 PP2C-like 105-381 6.4e-53 172.4 In-house 3-233 (235) alignment 
Range on Protein: 105-381
Range on HMM: 3-233/235.0
IRYGMSSMQGW-RICMEDSHIAeaimsqsspykDWSFFAVFDGHAGHHIANRASSQLLEHLISSEEFremtktleenngVLTDSTLKLLEKGIKKGFLSF
...|..|..|. |  .||....           ....|||.||| ||. .. ||..|.|.|..  .              |. .....|.| ...    .
lsvgaasdigrvrkvneDavlv...........glllfavaDGhgghaagevasellvetllellle............lllldleealrkaflaaneal

DEISKTSNDISKSGCTAVCAIVTPTHFIIGNLGDSRAVVAGKNE-IFGTEDHKPYLEKERKRIEGAGGSVmiqRINGSLAVSRAFGDYEYKddprlpadq
 | ...|.... .|.|||.|.... .... |.|||||..  ... .. ||||.|. | ||.||. ||| |   |..|.||..||.||...|         
lelalaspelagmgtTavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav...rvpgrlaltralGdlllk.........

qlvspepdVYIRERNLENDQFMVVACDGIYDVMTNEELAEFVKDrlsvhSDLREVCDDVLDECLVKGSRDNMTMVVVCF
        ..... .||.. |...|.||..||...||.......      ||.|... .....| .|.|||.| |||..
........pdvtvlelepgdflllasDGlwdvlsdeeivdllrs.....ldleeaaerlvelalarggrDNiTvvvvrl
subfamily_PPM1E_pd Subfamily PPM1E 109-381 1.5e-50 164.8 In-house 8-262 (265) alignment 
Range on Protein: 109-381
Range on HMM: 8-262/265.0
MSSMQGWRICMEDSHIAEAI---MSQSSPYKDWSFFAVFDGHAGHHIANRASSQLLEHLISSEEFREMTKtleenngvltdstlklleKGIKKGFLSFDE
. .... |  ||| |.|      . . .  |. .||||||||.|.. |. |...| |.|.. |.. | ..                  . .|..|   ||
iaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa..................ealkeafkltDe

--ISKTSNDISKSGCTAVCAIVTPTHFIIGNLGDSRAVVAGKNEIFG-TEDHKPYLEKERKRIEGAGGSVMI---QRINGSLAVSRAFGDYEYKddprlp
  ..|. ..  |||.|||.....  .. .. ||||.|..  | |.   .. |||  |.|.|||| ||| |.     |.||.|.|||| ||...|      
rflqkaereklksGstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklk......

adqQLVSPEPDVYIRERNlENDQFMVVACDGIYDVMTNEELAEFVKDRLSVHS-DLREVCDDVLDECLVKGSRDNMTMVVVCF
   . || |.||   | . ........||||..||...||. . |.. |. .. || ||   ....   .||.||.|.||| .
...pyvsgeadvaeveld.gseeylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvvfl
subfamily_PPM1G_pd Subfamily PPM1G 212-381 5.3e-49 160.5 In-house 292-470 (473) alignment 
Range on Protein: 212-381
Range on HMM: 292-470/473.0
DISKSGCTAVCAIVTPTHFIIGNLGDSRAVVAGKNEIFG-TEDHKPYLEKERKRIEGAGGSVM-IQRINGSLAVSRAFGDYEYKDDPRLPADQQLVSPEP
  ..||.||| |..   . |. | ||||.|.. . .     .||||  |.|..||| ||| |    |.|| | .|||.||. || .  ||. .|..|  |
pGedsGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplkeqmisAlP

DVYIRERnLENDQFMVVACDGIYDVMTNEELAEFVKDRLSVHS--DLREVCDDVLDECLVKGS------RDNMTMVVVCF
|. ...   |.|.|.|.|||||..||. .|  .||...|. ..   | |.....||.||..         ||||...|..
Dikvltl.teedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtviivll
PPM_PTC7_SpoIIE 106-377 5.9e-46 150.1 In-house 2-225 (230) alignment 
Range on Protein: 106-377
Range on HMM: 2-225/230.0
RYGMSSMQGWRICMEDSHIAEAIMSQSSPYKDWSFFAVFDGHAGHHiaNRASSQLLEHLISSEeFREMTktleenngvltdstlkLLEKGIKKGFLSF-D
..|.|..||.| .|||.||..| . .||.   . .....||| |.     |...| . | .   |....                ..|. .....| . .
dggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrela.fagle................kpeeilrrlnlalaa

EISKTsndISKSGCTAVCAIVTPTH--FIIGNLGDSRAVVAGKNEIfgtedhkpylekERKRIeGAGGSVM----IQRINGSLAVSRAFGDYEYKDdprl
.. ..    |.||.|||.|...|..  . . |.|||....  ...             ||.|| .||| ..     .|..|.||||.|.||. ...    
dlede...psssgaTavvalidpstgklyvanaGdsppllvrddgg............ereri.vagglpslGilpgrvfgvlavslapGdlllly....

paDQQLVSPEPDvYIRERNLENDQFMVVACDGIYDVMTNEELAEFVKDRLSVHsdlrevcddvldeCLVKGSRDNMTMV
    ..|..|||  ....  ..|.|...|.||..||....||...|.|.|. .             .  .. .| .|..
..tDGvveaepd.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp.............aaeglleDDitll
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 105-382 1.3e-41 135.6 In-house 6-254 (255) alignment 
Range on Protein: 105-382
Range on HMM: 6-254/255.0
IRYGMSSMQGWRICMEDSHIAEAIMSQSspyKDWSFFAVFDGHAGHHIANRASSQLlEHLisseefreMTKTLEENNGvltdSTLKLLEKGIKKGFLSFd
 . |.| | | |  |||. ..     .    .|  ..|.||||.|.. |. || .| ...        ... |. ||     . .| |.|  |.  . . 
fkvgfsdmiGrrptmedelviyGsfrdk...sdedyyalfdGhgGraaakfaseel.yki........laelldlnna....nPvkslkkaykeistqi.

eisktsNDI-SKSGCTAVCAIVTPTHFIIGNLGDSRAVVAGKNEIFG--TEDHKPYLEKERKRIEGAGGSVMIQ----RINGSLAVSRAFGDYeYKDdPr
      ..     |.||. ....  . .| |.||||.|.. |. .    . ||||  |.|.|||. .|| |. .    |.|| ||||||.||  . . | 
......serpkfiGttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGds.fle.P.

lpadqqLVSPEPDVYIRERNLENDQFMVVACDGIYDVMTNEELAEFVKDrlsvHSDLREVCDDVLDECLVKGSRDNMTMVVVCFP
       | |.||.    .. ..|.|...|||||.|....||  | | .     ||  . .  . |    .|| ||....|. ..
......fvvpdPdlsqsleiskkdkflilacdGiwdlisdeeaveivag....isdpekaaeklrdlayssGstdnisvivikls
subfamily_PPM1L_pd Subfamily PPM1L 110-381 3.2e-41 134.4 In-house 10-266 (269) alignment 
Range on Protein: 110-381
Range on HMM: 10-266/269.0
SSMQGWRICMEDSHIAEAIMSQSspyKDWSFFAVFDGHAGHHIANRASSQLLEHLIssEEFREMTKTLEENNGVltdSTLKLLEKGIKKGFLSFDEISKT
 |..| |  |||  . |  ....    . ||||||||| |   |. | . | . .   ... |. .  |..  .   .  |||.. |      . |  |.
ysvlGrrprmedrfeieediknk...tgesffavfdGhGGefaaefakdvlvkaik..nklieldadkentepi...nfsklltdeilsvdekllekakr

SNDIskSGCTAVCAIVTPTHFIIGNLGDSRAVVAGKN--EIFGTEDHKPYLEKERKRIEGAGGSVMI---QRINGSLAVSRAFGDYEYKDdprlpadQQL
..||  .|.||. |.|. ...|. |.|||| |.  |.   |  . ||||.  ||||||. ||| . .    |..| ||.|||.|||  ||       ..|
aedi..aGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkd.......knl

VSPEPDVYIRERNLENDQFMVVACDGIYDVMTNEELAEFVKDRLSVhSDLreVCDDVLDECLVKGSRDNMTMVVVCF
| ..||.   . .  . .|...|.||..| ..|||  .|.|.||.   |.      .  |.  .|| ||.|..|| .
viadpdiltfdlddhkpeflilasdGlwdtfsneeavrfikerlke.pdf..GakslvlesfkrGsvdnitvlvvkl
subfamily_ILKAP_pd Subfamily ILKAP 110-357 2.2e-39 128.4 In-house 10-252 (293) alignment 
Range on Protein: 110-357
Range on HMM: 10-252/293.0
SSMQGWRICMEDSHIAEA-IMSQ----SSPYKDWSFFAVFDGHAGHHIANRASSQLLEHLISSEEFREMTKTLEENNGVLTDStlkllekgIKKGFLSFD
.  .| |  |.|.|.    ...|    .|. .  |..||||||||.. .. |...| .....     ..... .|    |.||         ||    | 
aerkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvds........fkktdeefL

EISKTSNDISKSGCTAVCAIVTPTHFIIGNLGDSRAVVAGKNEI-------FGTEDHKPYLEKERKRIEGAGGSVMIQRINGSLAVSRAFGDYEYKddpr
.... .. . | |.||.. .|    . ..|||||.||.. |.|          | ||.|  ..|||||. |||.|   |..| | |||. || ..|    
klaskakPvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfk....

lpadQQLVSPEPDVYiRERNLENDQFMVVACDGIYDVMTNEELAEFVKDRLSVHSDLREV
    .  |.  |||  . .  |||.|.|.||||...|....| ..|. . |  . | |..
....rlGvistPdvk.kceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrki
subfamily_PPM1D_pd Subfamily PPM1D 110-381 1.2e-33 109.6 In-house 7-307 (309) alignment 
Range on Protein: 110-381
Range on HMM: 7-307/309.0
SSMQGWRICMEDSHIAEAIMSQSSPYKDWSFFAVFDGHAGHHIANRASSQLLEHLISSEEFreMTKTLEENNGVLTDSTLKlLEKGIKKGFLSFDeiSKT
.. || | .|||        ..|.  ....|.|||||| |.. |. |...|.. .   ..|  ...  |.    . .. |. ... .||   ..    ..
eadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkf..lssepedvleAireafla.theamkkkleeWp..ktk

SNDISKSGCTAVCAIVTPTHFIIGNLGDSRAVVAGKNE-------IFGTEDHKPYLEKERKRIEGAGGSVMIQ---------R----INGS--------L
|.. | .| || . |.. ... ... |||..|.. |..          |.||||   .|..||| .||.|...         |     ||         |
sgllstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngptvideiPFL

AVSRAFGDY-EYKDDprlpADQQLVSPEPDVYIRERNLENDQFMVVACDGIYDVMTNEELAEFVKDRLSVHSDL----REVCDDVLDECLVKGSR-----
||.|. ||   |.       .. .|||||||. |... ....|...| ||...|.| |.  ..|..  ....      |.|   ...| | . ..     
avaRslGDlWsynak....sgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklra

DNMTMVVVCF
||....||..
Dnvsvivvil
subfamily_PPM1K_pd Subfamily PPM1K 108-382 8.9e-30 96.7 In-house 7-259 (263) alignment 
Range on Protein: 108-382
Range on HMM: 7-259/263.0
GMSSMQGWRICMEDSHIAEAImsqsspYKDWSFFAVFDGHAGHHIANRASSQLLEHLissEEFREMTKTLEEnngVLTDSTLKllekgIKKGFLSFDEIS
|. |..| |   ||    . .       ..  ..||||||||   |. . ..| ..|   ... |  | ||.   ||... ..     ..| . .. | |
GkdsliGkraenedriklkel......dpellyvavfdGhaGsaaadfvhdklekil...krllekekdlei...vlknafee.....ldkklkrylefs

KTSNDISKSGCTAVCAIV-TPTHFIIGNLGDSRAVVAGKNEI-FGTEDHKPYLEKERKRIEGAGGSVMI-----QRINGSLAVSRAFGDYEYKddprlpa
 . ..  .|| ||  ...   |.... .||||||..  . .    |.||.| ||.|..||  |||||        ..|| ||..|..|| . |       
vaeaellssGttatvsllrdGtelvlaslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlk.......

dQQLVSPEPDVYIRERNLENDQFMVVACDGIYDVMTNEELAEFVKdrlsVHSDLREVCDDVLDECLVKGSRDNMTMVVVCFP
 .  |  .|.    . . ..| |.|.  ||| .|....||...|.    .  | .|  . . .  |  || || |.||| . 
.ryGviatPetkslkvdhaadsflvlitdgisfvvnsqelcdlvr....lchdpeeaahalteqalqygsednatavvvplg
subfamily_KAPP-like_pd Subfamily KAPP-like 115-379 5.3e-24 77.7 In-house 8-264 (266) alignment 
Range on Protein: 115-379
Range on HMM: 8-264/266.0
WRICMEDSHIAEAIMSQSSP---YKDWSFFAVFDGHAGHHIANRASsQLLEHLISseefREMTKTLEENNGVLTDSTLKLLEKgikkgflSFDEISKTSN
  . ||| ..|   . .        . ..|||||||||.  |. |. .|... .     . . .| ... |       ||||.       .|.|. .  .
cstemedvslaiypllkekklsncsnialfavfdGhaGkGaadaak.klfpkele....kllkstkqddGGdniydqskllen.......afkevdaklk

DISKSGCTAVCAIVTP---THFII-GNLGDSRAVVA-GKNEIFGTEDHKPYLEKERKRIEGAGGSVM--IQRINGsLAVSRAFGDYEYKDDprlpadQQL
|    |.||  |.|      ...  .|.||| | .. | . .. . |||   ..|..||   | ..     |||| ||||||.||.  |.       .  
dfeyeGatatlalvwsdGqqrylqvanvGdssaflsrGneslelskdhkakdpeekqrikddGitlsdnqtrinG.lavsralGdhfikel......niG

VSPEPDVYIRERNLENDQFMVVACDGIYDVMTNEELAEFVKDRLSvHSDLREVCDDVLDECLVKGS--RDNMTMVVV
.. || |  |      |.|..|| ||..||.. ..  | ||     . .  .   . | |. .. .  .||....||
lisepyvsnrilltpfdkflivasdGlwdvisGkdaiekvkslyd.qqatedkmasslletaiqsikakdnvsvivv
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 115-379 2.2e-21 68.9 In-house 7-274 (276) alignment 
Range on Protein: 115-379
Range on HMM: 7-274/276.0
WRICMEDSHIAEAIMSQSSP---YKDWSFFAVFDGHAGHHIANRASSQLLEHLISSEEFREMTKTLEENNGVLTDSTLKLLEKgikkgflSFDEISKTSN
  . ||| ..|   . .        . ..|||||||||.  |. |.  . . |    .  ... | ... |       ||| .        |.|. .  .
cstemedvslaiyplldekdlsncsnialfavfdGhaGkGaadaakklfpkelekllksgnysltkqddGGdniydqskllld.......lfkevdaklk

DISKSGCTAVCAIVTPTH----------FIIGNLGDSRAVVA-GKNEIFGTEDHKPYLEKERKRIEGAGGSVM--IQRINGsLAVSRAFGDYEYKDDprl
|    |.||  |.|                ..|.||| | .. | . .. . |||    .|..||   | ..     |||| ||||||.||.  |.    
dfeyeGatatlalvwsdGeeqqqqqqrylqvanvGdssaflsrGneslelskdhkatdpeekqrikddGitlsdnqtrinG.lavsralGdhfikel...

padQQLVSPEPDVYIRERNLENDQFMVVACDGIYDVMTNEELAEFVKDRLSvHSDLREVCDDVLDECLVKGS--RDNMTMVVV
   .  .. || |  |      |.|..|| ||..||.. ..  | ||     . .  .   . | |. .. .  .||....||
...niGlisepyvsnrilltpfdkflivasdGlwdvisGkdaiekvkslyd.qqatedkmasslletaiqsikakdnvsvivv
subfamily_PPM1G_pd Subfamily PPM1G 87-174 1e-18 60.6 In-house 1-85 (473) alignment 
Range on Protein: 87-174
Range on HMM: 1-85/473.0
FLDKPKTDKTNVHGEGNGIRYGMSSMQGWRICMEDSHIAEAIMSqsspyKDWSFFAVFDGHAGHHIANRASSQLLEHLISSEEFRE--MT
.|.|||..|.....  ....||.|.|||||  .||.| .   .      .|.|.|||.||| |. .|.  ...|.. |  .. ..|  ..
ylskpkvekesedesneelsygasamqGwrvsqEDahncitdld.....edtslfavyDGHGGkevakyvakklpdllkaqkgykegdve
subfamily_PDP_pd Subfamily PDP 208-354 1.9e-17 56.4 In-house 144-318 (398) alignment 
Range on Protein: 208-354
Range on HMM: 144-318/398.0
KTSNDISKSGCTAVCAIVTPTHFIIGNLGDSRAVVAGKNEIF------GTEDHKPYLEKERKRIEGAG---GS---VMIQRINGSLAVSRAFGDYEYKDD
... . . || .|..| . .|.. . | ||.|||.. ..|         ..|.    |.| .||. .     |   .. .|. |.|. .|||||..|| .
reallvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirngRlLgeLqPlRAFGdvryKws

PRLPA---DQ---QLVSP-----------EPDVYIReRNLENDQFMVVACDGIYDVMTNEELAEFVKDRLSVHSDL
  |      .   . . |           ||.|  . .  |||.|.|.| ||..|...||| .. |.. |. . . 
eelqkkvlekaylkvlepkdyktPPYltaePevtsh.klrendkFLvlatDGLwdllsneevvslVgehlakkkek
PP2C_SIG_SM00331 139-379 1.6e-16 53.5 In-house 31-215 (217) alignment 
Range on Protein: 139-379
Range on HMM: 31-215/217.0
SFFAVFDGHAGHHIANRASSQLLEHLISS--EEfREMTKTLEENNGVLTDStlkllekgikkgflsfdeisktsNDISKSGCTAVCAIV--TPTHFIIGN
 ...|.||. ... |. |||||.. |  .  |.  | ...|.. |... .                        .. . ...|...|..  .  .. . |
lllvvaDgmGkGlaAaaassqlrtalrellseg.eelsqalkrlnraiyee.......................keekgmfaTlllalydfssgklsyan

LGDSRAVVAG-KNEIFGTEDhkpylekerkriegaggsvmiqringslavsrafgdyeykddprlpADQQLVSPEPDVY--IRERNLENDQFMVVACDGI
.|||| .. . ..... ..|                                                ..... ||.|   |||..|| . ... . ||.
aGdsrpyllrdgklveilkd..............................................vegaplGlepevsvdirelelekgdllllytDGl

YDVM-----TNEELAEFVKDRL-SVHSDLRE-VCDDVLDECLVKGSRDNMTMVVV
 ...      .|.| |...| . | . .| .   ...| .   .. .|..|.|||
tearsekgfaeerleeiledlvdseaqelaqkiveellelakgsngeDdiTvvvv
subfamily_PP2D1_pd Subfamily PP2D1 216-352 1.5e-15 49.9 In-house 176-310 (492) alignment 
Range on Protein: 216-352
Range on HMM: 176-310/492.0
SGCTAVCAIVTPTHFIIGNLGDSRAVVA--GKNeIFGTEDHKPYLEKERKRIEGAGGSVM----IQRINGSLAVSRAFGDYeykDDPRLpadQQLVSPEP
.  .     . ..   | | |. .||.   ||  |  | .| |. .|||.|.| ||..|.      ..|| | . |  | |    ||.|   .. | |||
esngsevhleelgvlyianaGnvqAvLcreGka.iiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGny...GdpkL...kksvipeP

DVYIRERNlENDQFMVVACDGIYDVMTNEELAEFVKDRLSVHS
 .   . . |..||.|.|  |...|...|| .. ||. | .. 
kttsvkld.eaaqflvlAsnGlWevlseeevlsLvkqtlaiyk
PPM_PTC7_motif 325-374 5.5e-15 48.6 In-house 1-51 (51) alignment 
Range on Protein: 325-374
Range on HMM: 1-51/51.0
VVACDGIYDVMTNEELAEFVKDRLS-VHSDLREVCDDVLDECLVKGSRDNM
. |.||..||....|. ..|.|.||  . .. |.. .. ||.| .|| ||.
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni
Subfamily Dicty-PPM1L-like 255-381 2.5e-14 45.8 In-house 176-303 (305) alignment 
Range on Protein: 255-381
Range on HMM: 176-303/305.0
KPYLEKERKRIEGAGGSVMIQ---RINGSLAVSRAFGDYEYKddprlpadqQLVSPEPDVYIRERNLENDQFMVVACDGIYDVMTNEELAEFVKDRLSVH
. .|...| ||| ......     . |. | .||  || . |         .|| |..|  .   .  ||||.|.| ||...|. .... |.||. |  .
nnfldeiririeslqaalynygellvnrllkksrskGdknlk.........elviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdk

S-------DLREVCDDVLDECLVKGSRDNMTMVVVCF
|       |  |.   .  | . .||.||.|.|.. .
ssqkkiewdfneisrviveeavkrgsgDnitlviikl
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 140-279 1.5e-12 40.6 In-house 22-155 (292) alignment 
Range on Protein: 140-279
Range on HMM: 22-155/292.0
F-FAVFDGHA--GHHIANRASSQLLEHLISSeefremTKTLEENNGVLTdstLKLLEKGIKkgflsFDEIskTSNDISKSGCTAVCAIVTPT-HFIIGNL
|  ||.|||   |...|. | ..|  .|...      |. | | .  |    |..|. . |     .|.   | .   ... ..|||.|     .|. |.
flaavldGhGvnGdkvaqlaedtlevellel......trqlqelseall...lrildiaak.....ldkl..tidaresattavvcarvrddralilanv

GDSRAVVAG-----KNE-IFGTEDHKPYLEKERKRIEGAGGSVMIQRING
|||||..       ..| |  . ||||    ||.||  ||| |   |. |
GdsrallgrclggsdyeliPlsrdhkPedPderarilraGGrveptrvrg
PP2C_2 Protein phosphatase 2C 134-351 5.9e-11 35.1 Pfam-A 16-198 (212) alignment 
Range on Protein: 134-351
Range on HMM: 16-198/212.0
PY----KDWSFFAVFDGHAGHHIANRASSQLLEHLisSEEFREMTKTLEENNgvlTDSTLKLLEKGIKKGFLSFDEISKTSNDISKSGCTAVCAIVTPTH
 .    .|....|| ||.  .  . ...  . | .   | ...  .. .|..   .. .|. .|..| .    ..| ... ..... ..| ..|..||..
laireasdgwllaVADGaGsakrSdkGarlaveaa..gealeklleeeseqe...eeallrqieneilasvklkqeaeaqqeelkdyatTlllavitpge

FIIGNLGDSRAVVA---GKNEIFGTEDHKPYLEKerkriegaggsvmiqriNGS---------LavsrafgdyeykddprlpadqqlvspepdvYIRERN
......||...||    |. ...|..|.. |  .                   .         |                               ||. .
ivffqiGDgaivvrdrdgevqllgepdsgeyane.................ttfltsedaeeel..............................rirrlk

LENDQFMVVACDGIYDVMT-NEELAEFVKDRLSVH
||  .  ..  ||. | .. .|...|.....|.  
lepgdalllmTDGvsdslrkeepfrellaelletl
PP2C_2 Protein phosphatase 2C 134-351 5.9e-11 35.1 In-house 16-198 (212) alignment 
Range on Protein: 134-351
Range on HMM: 16-198/212.0
PY----KDWSFFAVFDGHAGHHIANRASSQLLEHLisSEEFREMTKTLEENNgvlTDSTLKLLEKGIKKGFLSFDEISKTSNDISKSGCTAVCAIVTPTH
 .    .|....|| ||.  .  . ...  . | .   | ...  .. .|..   .. .|. .|..| .    ..| ... ..... ..| ..|..||..
laireasdgwllaVADGaGsakrSdkGarlaveaa..gealeklleeeseqe...eeallrqieneilasvklkqeaeaqqeelkdyatTlllavitpge

FIIGNLGDSRAVVA---GKNEIFGTEDHKPYLEKerkriegaggsvmiqriNGS---------LavsrafgdyeykddprlpadqqlvspepdvYIRERN
......||...||    |. ...|..|.. |  .                   .         |                               ||. .
ivffqiGDgaivvrdrdgevqllgepdsgeyane.................ttfltsedaeeel..............................rirrlk

LENDQFMVVACDGIYDVMT-NEELAEFVKDRLSVH
||  .  ..  ||. | .. .|...|.....|.  
lepgdalllmTDGvsdslrkeepfrellaelletl
subfamily_PPM1H_pd Subfamily PPM1H 275-351 7.4e-10 31.1 In-house 275-354 (404) alignment 
Range on Protein: 275-351
Range on HMM: 275-354/404.0
QRINGSLAVSRAFGDYEYKDDPRLPADQQLVSPEPDVYIR---ERNLENDQFMVVACDGIYDVMTNEELAEFVKDRLSVH
.|. . ..|.| .||.| |        . ..||.|.| ..   . . ..|. ...| ||..||..||| || |.. ||  
aRllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskv
PPM_PTC7_SpoIIE_motif 315-381 2.2e-09 30.9 In-house 6-80 (81) alignment 
Range on Protein: 315-381
Range on HMM: 6-80/81.0
ERNLENDQFMVVACDGIY-------DVMTNEELAEFVKDRlSVHSdLREVCDDVLDECLVKG---SRDNMTMVVVCF
|  |...  .....||..       .....|||....... ...| | |..| ..||.|  |   ..|..|..|...
efqLkpgdvllLyTDGltEardsdgelfgkeellrladra.egks.lqeladklvdevlengsgereDDitllvlrv
subfamily_Choan-PPM-1_pd Subfamily Choan-PPM-1 305-383 1.4e-08 26.3 In-house 239-317 (317) alignment 
Range on Protein: 305-383
Range on HMM: 239-317/317.0
VSPEPDVYIRERNLENDQFMVVACDGIYDVMTNEELAEFVKDRLSVHSDLREVCDDVLDECLVKGSRDNMTMVVVCFPA
|. .|.|. |  . ..   .||  ||| | . .... . |    .     . .|||  | .| . | |. | ||...|.
viadPevrsrvldvdevfavvvvsdGitdelkrldvldrvlraataleasevlcddaqdylldetsiddatavvlllpl
subfamily_PPM1H_pd Subfamily PPM1H 197-265 2.4e-07 22.9 In-house 141-210 (404) alignment 
Range on Protein: 197-265
Range on HMM: 141-210/404.0
KKGFLSFDEI-SKTSNDI-SKSGCTAVCAIVTPTHFIIGNLGDSRAVVAGKNEIFG-TEDHKPylEKERKRI
 . ||. ||  ..  ..   | ||||. |.|    . . | |||||..  |.||    .|. |  | ||.|.
esaflemDeqiarereayrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftP..eteRqRl
subfamily_TAB1_pd Subfamily TAB1 205-364 3.5e-07 22.3 In-house 119-298 (333) alignment 
Range on Protein: 205-364
Range on HMM: 119-298/333.0
EISKTSNDISkSGCTAVCAIVTPTHFIIGNLGDSRAVVAG----KNEIFGTEDHKPYLEKERKRIEGAGGS-VMI--QRINGSLAVSRAFGDYE----YK
 ...  ..||  | ||| |..   .  . | |||||..      ..      ||.   |.| .|... |     |  ... ||    |. |||.    ||
rlqeleeeis.gGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkkgyk

DDPRL-PADQQLVSPEPDVYIRERNLENDQFMVVACDGIYDVMTNE--------E-LAEFVKDRLSVHSDLREVCDDVLDE
|   |  | .. |  |||.       .  .|.|.  ||.|  . .         | ..  |. .|  . .| .|  .|.|.
dvdilssakgePviaePdiqgaypiddityflvlmSdGvyktLeevtgpetsnvenillevitelekqatlqdvAqavvdk
subfamily_PDP_pd Subfamily PDP 119-177 1.4e-06 20.7 In-house 11-68 (398) alignment 
Range on Protein: 119-177
Range on HMM: 11-68/398.0
MEDSHIAeaimsQSSPYKDWSFFAVFDGHAGHHIANRASSQLLEHLISSE-EFREMTKT---L
.||.. .      ..  ..  .|.|||||.|.. |.  | .||...  |  . ......   |
iEDrrse.....akllesngvlfgvfDGHggaacaeavskrLlkyvaasllkkqvleeaekal
subfamily_PP2D1_pd Subfamily PP2D1 115-181 1.9e-06 19.8 In-house 13-78 (492) alignment 
Range on Protein: 115-181
Range on HMM: 13-78/492.0
WRICMEDSHIaeaIMSQSSPYKDWSFFAVFDGHAGHHIANRASSQLlEHLISSEEFR---EMTKTLEENN
|.  ||| .    ....  .  . .||...||. |   |. |...|  .....|  .   ... | ..| 
WKskmeDkrt...lqdyfgndvnscFfgiyDGynGataAeiaakel.hevlleelekvdervslttavnl
subfamily_PPM1H_pd Subfamily PPM1H 132-181 5.3e-06 18.4 In-house 56-103 (404) alignment 
Range on Protein: 132-181
Range on HMM: 56-103/404.0
SSPYKDWSFFAVFDGHAGHHIANRASSQLLEHLisSEEFREMTKTLEENN
 ..  .  .|..||||||. .|  || .| .||   |........| |..
eeeklplayfglfDGhaGsgaalvaskllhkhl..kekledvlellleks
Subfamily Dicty-PPM1L-like 106-242 9.2e-06 17.7 In-house 8-141 (305) alignment 
Range on Protein: 106-242
Range on HMM: 8-141/305.0
RYGMSSMQGWRICMEDSHIAEaIMSQSSpyKDWSFFAVFDGHAGHHIANRASSQLLEHLISseeFREMTK-TLEENNGVLTDSTLKLLEKGIKKGFLSFD
.|..   .. |   || .    |  .||  .. |.| ||||| |.  |. .  .|.| . .   .  . |     .|    |..|. ....  ..  |. 
kyelyvsansrkyqedrnkvk.isless..qelslfGvfdGhnGdiaaeyvkkklveivnk...yvkenkvGysaknlnvddlpleaiksaslstdkssl

EISKTSNdiSKSGCTA----VCAIVTPTHFIIGNLGDSRAVV
. ... |   |.| |        |.    .|  . .|. .|.
dsaesdn..kkaGttlngssasvilerertivstasdtevvl