Gene ppm-1 in Caenorhabditis elegans

Synonym: CELE_F25D1.1, ppm-1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1A
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP156_AA protein Get Run
CeleP156_AA_85-382 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1A_pd Subfamily PPM1A 95-382 8.5e-113 369.4 In-house 2-281 (282) alignment
Range on Protein: 95-382
Range on HMM: 2-281/282.0
KTNVHGEGNGIRYGMSSMQGWRICMEDSHIaeAIMSQSsPYKDWSFFAVFDGHAGHHIANRASSQLLEHLISSEEFREmtktleennGVLTDSTLKLLEK
| . ..||||.|||.|||||||..|||.|.  ...| .  .||||||||||||||...|. ....|||.....||..|           |..|. . ...
kpksqaegnglrygvssmqgwrvemEDaht..vvaslg.alkdwsfFavfDGHaGsevakyvkkhllenileeeelke.........aaleasekdevke

GIKKGFLSFDEISKTSNDIS----KSGCTAVCAIVTPTHFIIGNLGDSRAVVAGK-NEIFGTEDHKPYLEKERKRIEGAGGSVMIQRINGSLAVSRAFGD
....|||..||  ..... .    |||.|||...|...|.|| ||||||||.. . ...| ||||||. .||.|||| |||||...|.||.||||||.||
alrqgfLaldeairelstdlktadksGsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGD

YEYKDDPRLPADQQLVSPEPDVYIRERNLENDqFMVVACDGIYDVMTNEELAEFVKDRLSVHSDLREVCDDVLDECLVKGSRDNMTMVVVCFP
||||......|..||||.||.|.. ||. |.| |.|.|||||.||...||..|.|..||.|...|.||.....|..| ||||||....||.|.
yeykeeeekkaeeqlvsaepevtsierseedd.flvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsrDNlsvlvvlfa

PPM_PTC7 106-374 7.6e-90 293.8 In-house 2-259 (259) alignment
Range on Protein: 106-374
Range on HMM: 2-259/259.0
RYGMSSMQGWRICMEDSHIAEAIMSQSSPYKDWSFFAVFDGHAGHHIANRASSQLLEHLISSEEFREMTktleenngvltdstlkLLEKGIKKGFLS--F
..|.|..||.| .|||.|||.| ...||......||||||||.|...|. |...| |.| ....|.|..                .|||...|.||.  .
dggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeele................klekalrksflaldt

DEISKTSND---ISKSGCTAVCAIVTPTHFIIGNLGDSRAVVAGKNEIF--GTEDHKPYLEKERKRIEGAGGSVM---IQRINGSLAVSRAFGDYEYKDD
|| .|.|..    |.||.|||.|..|...... |.||||||........   ||||||..|.||.|||||||||.    .|.||.|||||||||.|.|..
deelksseantepstsGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpk

PRlpaDQQLVSPEPDVYIRERNLEnDQFMVVACDGIYDVMTNEELAEFVKDRLSVHsDLREVCDDVLDECLVKGSRDNM
..   ..||||.|||.. .... | |.|...|.||..||....|....|...|| . |..|......||.. .||.||.
et...eeqlvsaePdisstkidee.defliLasdGlwdvvsdqeavdlvrselskk.dpmeaaeklvdeaiargsedni

PP2C Protein phosphatase 2C 106-374 1.9e-89 292.6 Pfam-A 2-255 (255) alignment
Range on Protein: 106-374
Range on HMM: 2-255/255.0
RYGMSSMQGWRICMEDSHIAEAIMSQSSPYKDWSFFAVFDGHAGHHIANRASSQLLEHLISSEEFREMTktleenngvltdstlkLLEKGIKKGFLS-FD
..|.|..||.| .|||.|||.. ...||......||||||||.|...|. |...| |.| ....|.|..                ..||...|.||. .|
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele................kvekalrksfladtd

EISKTSND---ISKSGCTAVCAIVTPTHFIIGNLGDSRAVVAGKNEIF--GTEDHKPYLEKERKRIEGAGGSVM-IQRINGSLAVSRAFGDYEYKDDPrl
|  |.|..    ||||.|||.|......... |.||||||.. |....   ||||||. |.||.|||.|||||. ..|.|||||||||.||.|.|...  
eelksskantepsksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke..

padQQLVSPEPDVYIRERNLEnDQFMVVACDGIYDVMTNEELAEFVKDRLSVHSDLREVCDDVLDECLVKGSRDNM
   .||||.||||. .... | |.|...|.||..||....|....|...|| .....|......||.. .||.||.
...eqlvsaePdvtsvkltee.defliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni

PP2C Protein phosphatase 2C 106-374 1.9e-89 292.6 In-house 2-255 (255) alignment
Range on Protein: 106-374
Range on HMM: 2-255/255.0
RYGMSSMQGWRICMEDSHIAEAIMSQSSPYKDWSFFAVFDGHAGHHIANRASSQLLEHLISSEEFREMTktleenngvltdstlkLLEKGIKKGFLS-FD
..|.|..||.| .|||.|||.. ...||......||||||||.|...|. |...| |.| ....|.|..                ..||...|.||. .|
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele................kvekalrksfladtd

EISKTSND---ISKSGCTAVCAIVTPTHFIIGNLGDSRAVVAGKNEIF--GTEDHKPYLEKERKRIEGAGGSVM-IQRINGSLAVSRAFGDYEYKDDPrl
|  |.|..    ||||.|||.|......... |.||||||.. |....   ||||||. |.||.|||.|||||. ..|.|||||||||.||.|.|...  
eelksskantepsksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke..

padQQLVSPEPDVYIRERNLEnDQFMVVACDGIYDVMTNEELAEFVKDRLSVHSDLREVCDDVLDECLVKGSRDNM
   .||||.||||. .... | |.|...|.||..||....|....|...|| .....|......||.. .||.||.
...eqlvsaePdvtsvkltee.defliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni

subfamily_PPM1G2_pd Subfamily PPM1G2 88-381 3.7e-76 248.8 In-house 2-286 (287) alignment
Range on Protein: 88-381
Range on HMM: 2-286/287.0
LDKPKTDKTNVHGEGNGIRYGMSSMQGWRICMEDSHIAEAIMSQSSPYKDWSFFAVFDGHAGHHIANRASSQLLEHLISseefremtktleenngvLTDS
|..| ..| .  .. . .. | |.|||.|. |||.|| |  . . |  |. ..||||||| |...|. |...| . . .                  .. 
lsepvvakesascanaltkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiak.................kksf

TLKLLEKGIKKGFLSFDEISKTS---NDiSKSGCTAVCAIVTPTHFIIGNLGDSRAVVAGKNEIFG-TEDHKPYLEKERKRIEGAGGSVMIQRINGSLAV
.   ||. .|..||..||        .| ...|.||| .... ......| ||||||.. | ..   . ||||  |.|.|||. ||| | ..|.||.||.
kegaleqilkdafletDeellkdeklkd.esaGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfvelnrvngnLal

SRAFGDYEYKDDPRLPADQQLVSPEPDVYIRERNlENDQFMVVACDGIYDVMTNEELAEFVKDRLSVHSDLREVCDDVLDECLVKGSR------DNMTMV
|||.||.|.|.  ......|.|  .||| ..... |.| |.|.|||||.||.||.|. ..|. ||. . .| |.....||.|| . |.      ||||.|
sralgDfefkknvkkkpeeqivtavPDvlvkkld.eddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvv

VVCF
.|..
ivvl

0034914 PP2C-like 86-382 5.8e-75 244.7 In-house 2-291 (295) alignment
Range on Protein: 86-382
Range on HMM: 2-291/295.0
AFLDKPKTDKTNVHGEGNGIRYGMSSMQGWRICMEDSHIAEAimSQSSPYKDWSFFAVFDGHAGHHIANRASSQLLEHLISSEEFREM----Tktleenn
..|..|........ . . .|.|..|.||.|  .||....    .  |  .|...|.||||| ||..|. ||. |.|.|..  |   .    .       
lllslpllellllsslllllrvgvasdqGrrksneDavlvvl..nllslledlllfgvfDGhgGhaaaevasellvelllellekllllltls.......

gvltdstLKLLEKGIKKGFLSFDE----ISKTSNDISKSGCTAVCAIVTPTHFIIGNLGDSRAVVAGKNE-IFGTEDHKPYLEKERKRIEGAGGSVMIQR
       |  .|. ..|.||. ||     .  ... . ||.|||.|..........|.||||||.  ..| .. |.||||. | ||.||. ||| |.  |
.......ledieealrkaflaadeellelallrpelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavshgr

INGSLAVSRAFGDYEYKDDPRLPADQQLVSPEPDVYIRERNLENDQFMVVACDGIYDVMTNEELAEFVKDRLSVHSDLREVCDDVLDECLVKGSRDNMTM
.||.|||.||.||...|  ..|.. ..|||.||||...|..||.|.|...|.||..||..|||....|...|. . || |... ..|..| .|||||.| 
vngvlavtRalGdfdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTv

VVVCFP
|||...
vvvrln

PP2Cc_SM00332 97-379 8.7e-75 244.6 In-house 2-274 (274) alignment
Range on Protein: 97-379
Range on HMM: 2-274/274.0
NVHGEGNGIRYGMSSMQGWRICMEDSHIAEAIMSqssPYKDWSFFAVFDGHAGHHIANRASSQLLEHLISSEEFREMTKtleenngvltdstLKLLEKGI
...|...|..||.|||||||  ||| |.    ..   . .||.||.|||||.|. .|. .|..| |.|... .. . ..              .  |. .
sesgsnlglsygkssmqgwrksmeDahvvvvdlv...eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdel.............eddveeal

KKGFLSFDEISKTSNDI-----SKSGCTAVCAIVTPTHFIIGNLGDSRAVVAGKNE-IFGTEDHKPYLEKERKRIEGAGGSVMIQRINGSLAVSRAFGDY
||.|||.||   ....      ..||.|||.|...  .... |.||||||.. ... .  ..||||  |.|||||. |||.|. .|.||.|||||||||.
kkaflstdeeileeeqskelenalsGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdh

EYKDDPrlPADQQLVSPEPDVYIRERnLENDQFMVVACDGIYDVMTNEELAEFVKDRL--SVHSDLREVCDDVLDECLVK-GSRDNMTMVVV
..|.    .  .. ...||||.. .   ..|.|...|.||..||..|.|. ..|...|   .. |  |..... .|.. . ||.||.|.|||
flkknk..klkepyitaepdvkvvtl.tsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv

0049733 PP2C-like 105-381 6.4e-53 172.4 In-house 3-233 (235) alignment
Range on Protein: 105-381
Range on HMM: 3-233/235.0
IRYGMSSMQGW-RICMEDSHIAeaimsqsspykDWSFFAVFDGHAGHHIANRASSQLLEHLISSEEFremtktleenngVLTDSTLKLLEKGIKKGFLSF
...|..|..|. |  .||....           ....|||.||| ||. .. ||..|.|.|..  .              |. .....|.| ...    .
lsvgaasdigrvrkvneDavlv...........glllfavaDGhgghaagevasellvetllellle............lllldleealrkaflaaneal

DEISKTSNDISKSGCTAVCAIVTPTHFIIGNLGDSRAVVAGKNE-IFGTEDHKPYLEKERKRIEGAGGSVmiqRINGSLAVSRAFGDYEYKddprlpadq
 | ...|.... .|.|||.|.... .... |.|||||..  ... .. ||||.|. | ||.||. ||| |   |..|.||..||.||...|         
lelalaspelagmgtTavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav...rvpgrlaltralGdlllk.........

qlvspepdVYIRERNLENDQFMVVACDGIYDVMTNEELAEFVKDrlsvhSDLREVCDDVLDECLVKGSRDNMTMVVVCF
        ..... .||.. |...|.||..||...||.......      ||.|... .....| .|.|||.| |||..
........pdvtvlelepgdflllasDGlwdvlsdeeivdllrs.....ldleeaaerlvelalarggrDNiTvvvvrl

subfamily_PPM1E_pd Subfamily PPM1E 109-381 1.5e-50 164.8 In-house 8-262 (265) alignment
Range on Protein: 109-381
Range on HMM: 8-262/265.0
MSSMQGWRICMEDSHIAEAI---MSQSSPYKDWSFFAVFDGHAGHHIANRASSQLLEHLISSEEFREMTKtleenngvltdstlklleKGIKKGFLSFDE
. .... |  ||| |.|      . . .  |. .||||||||.|.. |. |...| |.|.. |.. | ..                  . .|..|   ||
iaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa..................ealkeafkltDe

--ISKTSNDISKSGCTAVCAIVTPTHFIIGNLGDSRAVVAGKNEIFG-TEDHKPYLEKERKRIEGAGGSVMI---QRINGSLAVSRAFGDYEYKddprlp
  ..|. ..  |||.|||.....  .. .. ||||.|..  | |.   .. |||  |.|.|||| ||| |.     |.||.|.|||| ||...|      
rflqkaereklksGstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklk......

adqQLVSPEPDVYIRERNlENDQFMVVACDGIYDVMTNEELAEFVKDRLSVHS-DLREVCDDVLDECLVKGSRDNMTMVVVCF
   . || |.||   | . ........||||..||...||. . |.. |. .. || ||   ....   .||.||.|.||| .
...pyvsgeadvaeveld.gseeylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvvfl

subfamily_PPM1G_pd Subfamily PPM1G 212-381 5.3e-49 160.5 In-house 292-470 (473) alignment
Range on Protein: 212-381
Range on HMM: 292-470/473.0
DISKSGCTAVCAIVTPTHFIIGNLGDSRAVVAGKNEIFG-TEDHKPYLEKERKRIEGAGGSVM-IQRINGSLAVSRAFGDYEYKDDPRLPADQQLVSPEP
  ..||.||| |..   . |. | ||||.|.. . .     .||||  |.|..||| ||| |    |.|| | .|||.||. || .  ||. .|..|  |
pGedsGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplkeqmisAlP

DVYIRERnLENDQFMVVACDGIYDVMTNEELAEFVKDRLSVHS--DLREVCDDVLDECLVKGS------RDNMTMVVVCF
|. ...   |.|.|.|.|||||..||. .|  .||...|. ..   | |.....||.||..         ||||...|..
Dikvltl.teedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtviivll

PPM_PTC7_SpoIIE 106-377 5.9e-46 150.1 In-house 2-225 (230) alignment
Range on Protein: 106-377
Range on HMM: 2-225/230.0
RYGMSSMQGWRICMEDSHIAEAIMSQSSPYKDWSFFAVFDGHAGHHiaNRASSQLLEHLISSEeFREMTktleenngvltdstlkLLEKGIKKGFLSF-D
..|.|..||.| .|||.||..| . .||.   . .....||| |.     |...| . | .   |....                ..|. .....| . .
dggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrela.fagle................kpeeilrrlnlalaa

EISKTsndISKSGCTAVCAIVTPTH--FIIGNLGDSRAVVAGKNEIfgtedhkpylekERKRIeGAGGSVM----IQRINGSLAVSRAFGDYEYKDdprl
.. ..    |.||.|||.|...|..  . . |.|||....  ...             ||.|| .||| ..     .|..|.||||.|.||. ...    
dlede...psssgaTavvalidpstgklyvanaGdsppllvrddgg............ereri.vagglpslGilpgrvfgvlavslapGdlllly....

paDQQLVSPEPDvYIRERNLENDQFMVVACDGIYDVMTNEELAEFVKDRLSVHsdlrevcddvldeCLVKGSRDNMTMV
    ..|..|||  ....  ..|.|...|.||..||....||...|.|.|. .             .  .. .| .|..
..tDGvveaepd.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp.............aaeglleDDitll

subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 105-382 1.3e-41 135.6 In-house 6-254 (255) alignment
Range on Protein: 105-382
Range on HMM: 6-254/255.0
IRYGMSSMQGWRICMEDSHIAEAIMSQSspyKDWSFFAVFDGHAGHHIANRASSQLlEHLisseefreMTKTLEENNGvltdSTLKLLEKGIKKGFLSFd
 . |.| | | |  |||. ..     .    .|  ..|.||||.|.. |. || .| ...        ... |. ||     . .| |.|  |.  . . 
fkvgfsdmiGrrptmedelviyGsfrdk...sdedyyalfdGhgGraaakfaseel.yki........laelldlnna....nPvkslkkaykeistqi.

eisktsNDI-SKSGCTAVCAIVTPTHFIIGNLGDSRAVVAGKNEIFG--TEDHKPYLEKERKRIEGAGGSVMIQ----RINGSLAVSRAFGDYeYKDdPr
      ..     |.||. ....  . .| |.||||.|.. |. .    . ||||  |.|.|||. .|| |. .    |.|| ||||||.||  . . | 
......serpkfiGttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGds.fle.P.

lpadqqLVSPEPDVYIRERNLENDQFMVVACDGIYDVMTNEELAEFVKDrlsvHSDLREVCDDVLDECLVKGSRDNMTMVVVCFP
       | |.||.    .. ..|.|...|||||.|....||  | | .     ||  . .  . |    .|| ||....|. ..
......fvvpdPdlsqsleiskkdkflilacdGiwdlisdeeaveivag....isdpekaaeklrdlayssGstdnisvivikls

subfamily_PPM1L_pd Subfamily PPM1L 110-381 3.2e-41 134.4 In-house 10-266 (269) alignment
Range on Protein: 110-381
Range on HMM: 10-266/269.0
SSMQGWRICMEDSHIAEAIMSQSspyKDWSFFAVFDGHAGHHIANRASSQLLEHLIssEEFREMTKTLEENNGVltdSTLKLLEKGIKKGFLSFDEISKT
 |..| |  |||  . |  ....    . ||||||||| |   |. | . | . .   ... |. .  |..  .   .  |||.. |      . |  |.
ysvlGrrprmedrfeieediknk...tgesffavfdGhGGefaaefakdvlvkaik..nklieldadkentepi...nfsklltdeilsvdekllekakr

SNDIskSGCTAVCAIVTPTHFIIGNLGDSRAVVAGKN--EIFGTEDHKPYLEKERKRIEGAGGSVMI---QRINGSLAVSRAFGDYEYKDdprlpadQQL
..||  .|.||. |.|. ...|. |.|||| |.  |.   |  . ||||.  ||||||. ||| . .    |..| ||.|||.|||  ||       ..|
aedi..aGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkd.......knl

VSPEPDVYIRERNLENDQFMVVACDGIYDVMTNEELAEFVKDRLSVhSDLreVCDDVLDECLVKGSRDNMTMVVVCF
| ..||.   . .  . .|...|.||..| ..|||  .|.|.||.   |.      .  |.  .|| ||.|..|| .
viadpdiltfdlddhkpeflilasdGlwdtfsneeavrfikerlke.pdf..GakslvlesfkrGsvdnitvlvvkl

subfamily_ILKAP_pd Subfamily ILKAP 110-357 2.2e-39 128.4 In-house 10-252 (293) alignment
Range on Protein: 110-357
Range on HMM: 10-252/293.0
SSMQGWRICMEDSHIAEA-IMSQ----SSPYKDWSFFAVFDGHAGHHIANRASSQLLEHLISSEEFREMTKTLEENNGVLTDStlkllekgIKKGFLSFD
.  .| |  |.|.|.    ...|    .|. .  |..||||||||.. .. |...| .....     ..... .|    |.||         ||    | 
aerkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvds........fkktdeefL

EISKTSNDISKSGCTAVCAIVTPTHFIIGNLGDSRAVVAGKNEI-------FGTEDHKPYLEKERKRIEGAGGSVMIQRINGSLAVSRAFGDYEYKddpr
.... .. . | |.||.. .|    . ..|||||.||.. |.|          | ||.|  ..|||||. |||.|   |..| | |||. || ..|    
klaskakPvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfk....

lpadQQLVSPEPDVYiRERNLENDQFMVVACDGIYDVMTNEELAEFVKDRLSVHSDLREV
    .  |.  |||  . .  |||.|.|.||||...|....| ..|. . |  . | |..
....rlGvistPdvk.kceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrki

subfamily_PPM1D_pd Subfamily PPM1D 110-381 1.2e-33 109.6 In-house 7-307 (309) alignment
Range on Protein: 110-381
Range on HMM: 7-307/309.0
SSMQGWRICMEDSHIAEAIMSQSSPYKDWSFFAVFDGHAGHHIANRASSQLLEHLISSEEFreMTKTLEENNGVLTDSTLKlLEKGIKKGFLSFDeiSKT
.. || | .|||        ..|.  ....|.|||||| |.. |. |...|.. .   ..|  ...  |.    . .. |. ... .||   ..    ..
eadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkf..lssepedvleAireafla.theamkkkleeWp..ktk

SNDISKSGCTAVCAIVTPTHFIIGNLGDSRAVVAGKNE-------IFGTEDHKPYLEKERKRIEGAGGSVMIQ---------R----INGS--------L
|.. | .| || . |.. ... ... |||..|.. |..          |.||||   .|..||| .||.|...         |     ||         |
sgllstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngptvideiPFL

AVSRAFGDY-EYKDDprlpADQQLVSPEPDVYIRERNLENDQFMVVACDGIYDVMTNEELAEFVKDRLSVHSDL----REVCDDVLDECLVKGSR-----
||.|. ||   |.       .. .|||||||. |... ....|...| ||...|.| |.  ..|..  ....      |.|   ...| | . ..     
avaRslGDlWsynak....sgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklra

DNMTMVVVCF
||....||..
Dnvsvivvil

subfamily_PPM1K_pd Subfamily PPM1K 108-382 8.9e-30 96.7 In-house 7-259 (263) alignment
Range on Protein: 108-382
Range on HMM: 7-259/263.0
GMSSMQGWRICMEDSHIAEAImsqsspYKDWSFFAVFDGHAGHHIANRASSQLLEHLissEEFREMTKTLEEnngVLTDSTLKllekgIKKGFLSFDEIS
|. |..| |   ||    . .       ..  ..||||||||   |. . ..| ..|   ... |  | ||.   ||... ..     ..| . .. | |
GkdsliGkraenedriklkel......dpellyvavfdGhaGsaaadfvhdklekil...krllekekdlei...vlknafee.....ldkklkrylefs

KTSNDISKSGCTAVCAIV-TPTHFIIGNLGDSRAVVAGKNEI-FGTEDHKPYLEKERKRIEGAGGSVMI-----QRINGSLAVSRAFGDYEYKddprlpa
 . ..  .|| ||  ...   |.... .||||||..  . .    |.||.| ||.|..||  |||||        ..|| ||..|..|| . |       
vaeaellssGttatvsllrdGtelvlaslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlk.......

dQQLVSPEPDVYIRERNLENDQFMVVACDGIYDVMTNEELAEFVKdrlsVHSDLREVCDDVLDECLVKGSRDNMTMVVVCFP
 .  |  .|.    . . ..| |.|.  ||| .|....||...|.    .  | .|  . . .  |  || || |.||| . 
.ryGviatPetkslkvdhaadsflvlitdgisfvvnsqelcdlvr....lchdpeeaahalteqalqygsednatavvvplg

subfamily_KAPP-like_pd Subfamily KAPP-like 115-379 5.3e-24 77.7 In-house 8-264 (266) alignment
Range on Protein: 115-379
Range on HMM: 8-264/266.0
WRICMEDSHIAEAIMSQSSP---YKDWSFFAVFDGHAGHHIANRASsQLLEHLISseefREMTKTLEENNGVLTDSTLKLLEKgikkgflSFDEISKTSN
  . ||| ..|   . .        . ..|||||||||.  |. |. .|... .     . . .| ... |       ||||.       .|.|. .  .
cstemedvslaiypllkekklsncsnialfavfdGhaGkGaadaak.klfpkele....kllkstkqddGGdniydqskllen.......afkevdaklk

DISKSGCTAVCAIVTP---THFII-GNLGDSRAVVA-GKNEIFGTEDHKPYLEKERKRIEGAGGSVM--IQRINGsLAVSRAFGDYEYKDDprlpadQQL
|    |.||  |.|      ...  .|.||| | .. | . .. . |||   ..|..||   | ..     |||| ||||||.||.  |.       .  
dfeyeGatatlalvwsdGqqrylqvanvGdssaflsrGneslelskdhkakdpeekqrikddGitlsdnqtrinG.lavsralGdhfikel......niG

VSPEPDVYIRERNLENDQFMVVACDGIYDVMTNEELAEFVKDRLSvHSDLREVCDDVLDECLVKGS--RDNMTMVVV
.. || |  |      |.|..|| ||..||.. ..  | ||     . .  .   . | |. .. .  .||....||
lisepyvsnrilltpfdkflivasdGlwdvisGkdaiekvkslyd.qqatedkmasslletaiqsikakdnvsvivv

subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 115-379 2.2e-21 68.9 In-house 7-274 (276) alignment
Range on Protein: 115-379
Range on HMM: 7-274/276.0
WRICMEDSHIAEAIMSQSSP---YKDWSFFAVFDGHAGHHIANRASSQLLEHLISSEEFREMTKTLEENNGVLTDSTLKLLEKgikkgflSFDEISKTSN
  . ||| ..|   . .        . ..|||||||||.  |. |.  . . |    .  ... | ... |       ||| .        |.|. .  .
cstemedvslaiyplldekdlsncsnialfavfdGhaGkGaadaakklfpkelekllksgnysltkqddGGdniydqskllld.......lfkevdaklk

DISKSGCTAVCAIVTPTH----------FIIGNLGDSRAVVA-GKNEIFGTEDHKPYLEKERKRIEGAGGSVM--IQRINGsLAVSRAFGDYEYKDDprl
|    |.||  |.|                ..|.||| | .. | . .. . |||    .|..||   | ..     |||| ||||||.||.  |.    
dfeyeGatatlalvwsdGeeqqqqqqrylqvanvGdssaflsrGneslelskdhkatdpeekqrikddGitlsdnqtrinG.lavsralGdhfikel...

padQQLVSPEPDVYIRERNLENDQFMVVACDGIYDVMTNEELAEFVKDRLSvHSDLREVCDDVLDECLVKGS--RDNMTMVVV
   .  .. || |  |      |.|..|| ||..||.. ..  | ||     . .  .   . | |. .. .  .||....||
...niGlisepyvsnrilltpfdkflivasdGlwdvisGkdaiekvkslyd.qqatedkmasslletaiqsikakdnvsvivv

subfamily_PPM1G_pd Subfamily PPM1G 87-174 1e-18 60.6 In-house 1-85 (473) alignment
Range on Protein: 87-174
Range on HMM: 1-85/473.0
FLDKPKTDKTNVHGEGNGIRYGMSSMQGWRICMEDSHIAEAIMSqsspyKDWSFFAVFDGHAGHHIANRASSQLLEHLISSEEFRE--MT
.|.|||..|.....  ....||.|.|||||  .||.| .   .      .|.|.|||.||| |. .|.  ...|.. |  .. ..|  ..
ylskpkvekesedesneelsygasamqGwrvsqEDahncitdld.....edtslfavyDGHGGkevakyvakklpdllkaqkgykegdve

subfamily_PDP_pd Subfamily PDP 208-354 1.9e-17 56.4 In-house 144-318 (398) alignment
Range on Protein: 208-354
Range on HMM: 144-318/398.0
KTSNDISKSGCTAVCAIVTPTHFIIGNLGDSRAVVAGKNEIF------GTEDHKPYLEKERKRIEGAG---GS---VMIQRINGSLAVSRAFGDYEYKDD
... . . || .|..| . .|.. . | ||.|||.. ..|         ..|.    |.| .||. .     |   .. .|. |.|. .|||||..|| .
reallvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirngRlLgeLqPlRAFGdvryKws

PRLPA---DQ---QLVSP-----------EPDVYIReRNLENDQFMVVACDGIYDVMTNEELAEFVKDRLSVHSDL
  |      .   . . |           ||.|  . .  |||.|.|.| ||..|...||| .. |.. |. . . 
eelqkkvlekaylkvlepkdyktPPYltaePevtsh.klrendkFLvlatDGLwdllsneevvslVgehlakkkek

PP2C_SIG_SM00331 139-379 1.6e-16 53.5 In-house 31-215 (217) alignment
Range on Protein: 139-379
Range on HMM: 31-215/217.0
SFFAVFDGHAGHHIANRASSQLLEHLISS--EEfREMTKTLEENNGVLTDStlkllekgikkgflsfdeisktsNDISKSGCTAVCAIV--TPTHFIIGN
 ...|.||. ... |. |||||.. |  .  |.  | ...|.. |... .                        .. . ...|...|..  .  .. . |
lllvvaDgmGkGlaAaaassqlrtalrellseg.eelsqalkrlnraiyee.......................keekgmfaTlllalydfssgklsyan

LGDSRAVVAG-KNEIFGTEDhkpylekerkriegaggsvmiqringslavsrafgdyeykddprlpADQQLVSPEPDVY--IRERNLENDQFMVVACDGI
.|||| .. . ..... ..|                                                ..... ||.|   |||..|| . ... . ||.
aGdsrpyllrdgklveilkd..............................................vegaplGlepevsvdirelelekgdllllytDGl

YDVM-----TNEELAEFVKDRL-SVHSDLRE-VCDDVLDECLVKGSRDNMTMVVV
 ...      .|.| |...| . | . .| .   ...| .   .. .|..|.|||
tearsekgfaeerleeiledlvdseaqelaqkiveellelakgsngeDdiTvvvv

subfamily_PP2D1_pd Subfamily PP2D1 216-352 1.5e-15 49.9 In-house 176-310 (492) alignment
Range on Protein: 216-352
Range on HMM: 176-310/492.0
SGCTAVCAIVTPTHFIIGNLGDSRAVVA--GKNeIFGTEDHKPYLEKERKRIEGAGGSVM----IQRINGSLAVSRAFGDYeykDDPRLpadQQLVSPEP
.  .     . ..   | | |. .||.   ||  |  | .| |. .|||.|.| ||..|.      ..|| | . |  | |    ||.|   .. | |||
esngsevhleelgvlyianaGnvqAvLcreGka.iiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGny...GdpkL...kksvipeP

DVYIRERNlENDQFMVVACDGIYDVMTNEELAEFVKDRLSVHS
 .   . . |..||.|.|  |...|...|| .. ||. | .. 
kttsvkld.eaaqflvlAsnGlWevlseeevlsLvkqtlaiyk

PPM_PTC7_motif 325-374 5.5e-15 48.6 In-house 1-51 (51) alignment
Range on Protein: 325-374
Range on HMM: 1-51/51.0
VVACDGIYDVMTNEELAEFVKDRLS-VHSDLREVCDDVLDECLVKGSRDNM
. |.||..||....|. ..|.|.||  . .. |.. .. ||.| .|| ||.
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni

Subfamily Dicty-PPM1L-like 255-381 2.5e-14 45.8 In-house 176-303 (305) alignment
Range on Protein: 255-381
Range on HMM: 176-303/305.0
KPYLEKERKRIEGAGGSVMIQ---RINGSLAVSRAFGDYEYKddprlpadqQLVSPEPDVYIRERNLENDQFMVVACDGIYDVMTNEELAEFVKDRLSVH
. .|...| ||| ......     . |. | .||  || . |         .|| |..|  .   .  ||||.|.| ||...|. .... |.||. |  .
nnfldeiririeslqaalynygellvnrllkksrskGdknlk.........elviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdk

S-------DLREVCDDVLDECLVKGSRDNMTMVVVCF
|       |  |.   .  | . .||.||.|.|.. .
ssqkkiewdfneisrviveeavkrgsgDnitlviikl

subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 140-279 1.5e-12 40.6 In-house 22-155 (292) alignment
Range on Protein: 140-279
Range on HMM: 22-155/292.0
F-FAVFDGHA--GHHIANRASSQLLEHLISSeefremTKTLEENNGVLTdstLKLLEKGIKkgflsFDEIskTSNDISKSGCTAVCAIVTPT-HFIIGNL
|  ||.|||   |...|. | ..|  .|...      |. | | .  |    |..|. . |     .|.   | .   ... ..|||.|     .|. |.
flaavldGhGvnGdkvaqlaedtlevellel......trqlqelseall...lrildiaak.....ldkl..tidaresattavvcarvrddralilanv

GDSRAVVAG-----KNE-IFGTEDHKPYLEKERKRIEGAGGSVMIQRING
|||||..       ..| |  . ||||    ||.||  ||| |   |. |
GdsrallgrclggsdyeliPlsrdhkPedPderarilraGGrveptrvrg

PP2C_2 Protein phosphatase 2C 134-351 5.9e-11 35.1 Pfam-A 16-198 (212) alignment
Range on Protein: 134-351
Range on HMM: 16-198/212.0
PY----KDWSFFAVFDGHAGHHIANRASSQLLEHLisSEEFREMTKTLEENNgvlTDSTLKLLEKGIKKGFLSFDEISKTSNDISKSGCTAVCAIVTPTH
 .    .|....|| ||.  .  . ...  . | .   | ...  .. .|..   .. .|. .|..| .    ..| ... ..... ..| ..|..||..
laireasdgwllaVADGaGsakrSdkGarlaveaa..gealeklleeeseqe...eeallrqieneilasvklkqeaeaqqeelkdyatTlllavitpge

FIIGNLGDSRAVVA---GKNEIFGTEDHKPYLEKerkriegaggsvmiqriNGS---------LavsrafgdyeykddprlpadqqlvspepdvYIRERN
......||...||    |. ...|..|.. |  .                   .         |                               ||. .
ivffqiGDgaivvrdrdgevqllgepdsgeyane.................ttfltsedaeeel..............................rirrlk

LENDQFMVVACDGIYDVMT-NEELAEFVKDRLSVH
||  .  ..  ||. | .. .|...|.....|.  
lepgdalllmTDGvsdslrkeepfrellaelletl

PP2C_2 Protein phosphatase 2C 134-351 5.9e-11 35.1 In-house 16-198 (212) alignment
Range on Protein: 134-351
Range on HMM: 16-198/212.0
PY----KDWSFFAVFDGHAGHHIANRASSQLLEHLisSEEFREMTKTLEENNgvlTDSTLKLLEKGIKKGFLSFDEISKTSNDISKSGCTAVCAIVTPTH
 .    .|....|| ||.  .  . ...  . | .   | ...  .. .|..   .. .|. .|..| .    ..| ... ..... ..| ..|..||..
laireasdgwllaVADGaGsakrSdkGarlaveaa..gealeklleeeseqe...eeallrqieneilasvklkqeaeaqqeelkdyatTlllavitpge

FIIGNLGDSRAVVA---GKNEIFGTEDHKPYLEKerkriegaggsvmiqriNGS---------LavsrafgdyeykddprlpadqqlvspepdvYIRERN
......||...||    |. ...|..|.. |  .                   .         |                               ||. .
ivffqiGDgaivvrdrdgevqllgepdsgeyane.................ttfltsedaeeel..............................rirrlk

LENDQFMVVACDGIYDVMT-NEELAEFVKDRLSVH
||  .  ..  ||. | .. .|...|.....|.  
lepgdalllmTDGvsdslrkeepfrellaelletl

subfamily_PPM1H_pd Subfamily PPM1H 275-351 7.4e-10 31.1 In-house 275-354 (404) alignment
Range on Protein: 275-351
Range on HMM: 275-354/404.0
QRINGSLAVSRAFGDYEYKDDPRLPADQQLVSPEPDVYIR---ERNLENDQFMVVACDGIYDVMTNEELAEFVKDRLSVH
.|. . ..|.| .||.| |        . ..||.|.| ..   . . ..|. ...| ||..||..||| || |.. ||  
aRllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskv

PPM_PTC7_SpoIIE_motif 315-381 2.2e-09 30.9 In-house 6-80 (81) alignment
Range on Protein: 315-381
Range on HMM: 6-80/81.0
ERNLENDQFMVVACDGIY-------DVMTNEELAEFVKDRlSVHSdLREVCDDVLDECLVKG---SRDNMTMVVVCF
|  |...  .....||..       .....|||....... ...| | |..| ..||.|  |   ..|..|..|...
efqLkpgdvllLyTDGltEardsdgelfgkeellrladra.egks.lqeladklvdevlengsgereDDitllvlrv

subfamily_Choan-PPM-1_pd Subfamily Choan-PPM-1 305-383 1.4e-08 26.3 In-house 239-317 (317) alignment
Range on Protein: 305-383
Range on HMM: 239-317/317.0
VSPEPDVYIRERNLENDQFMVVACDGIYDVMTNEELAEFVKDRLSVHSDLREVCDDVLDECLVKGSRDNMTMVVVCFPA
|. .|.|. |  . ..   .||  ||| | . .... . |    .     . .|||  | .| . | |. | ||...|.
viadPevrsrvldvdevfavvvvsdGitdelkrldvldrvlraataleasevlcddaqdylldetsiddatavvlllpl

subfamily_PPM1H_pd Subfamily PPM1H 197-265 2.4e-07 22.9 In-house 141-210 (404) alignment
Range on Protein: 197-265
Range on HMM: 141-210/404.0
KKGFLSFDEI-SKTSNDI-SKSGCTAVCAIVTPTHFIIGNLGDSRAVVAGKNEIFG-TEDHKPylEKERKRI
 . ||. ||  ..  ..   | ||||. |.|    . . | |||||..  |.||    .|. |  | ||.|.
esaflemDeqiarereayrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftP..eteRqRl

subfamily_TAB1_pd Subfamily TAB1 205-364 3.5e-07 22.3 In-house 119-298 (333) alignment
Range on Protein: 205-364
Range on HMM: 119-298/333.0
EISKTSNDISkSGCTAVCAIVTPTHFIIGNLGDSRAVVAG----KNEIFGTEDHKPYLEKERKRIEGAGGS-VMI--QRINGSLAVSRAFGDYE----YK
 ...  ..||  | ||| |..   .  . | |||||..      ..      ||.   |.| .|... |     |  ... ||    |. |||.    ||
rlqeleeeis.gGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkkgyk

DDPRL-PADQQLVSPEPDVYIRERNLENDQFMVVACDGIYDVMTNE--------E-LAEFVKDRLSVHSDLREVCDDVLDE
|   |  | .. |  |||.       .  .|.|.  ||.|  . .         | ..  |. .|  . .| .|  .|.|.
dvdilssakgePviaePdiqgaypiddityflvlmSdGvyktLeevtgpetsnvenillevitelekqatlqdvAqavvdk

subfamily_PDP_pd Subfamily PDP 119-177 1.4e-06 20.7 In-house 11-68 (398) alignment
Range on Protein: 119-177
Range on HMM: 11-68/398.0
MEDSHIAeaimsQSSPYKDWSFFAVFDGHAGHHIANRASSQLLEHLISSE-EFREMTKT---L
.||.. .      ..  ..  .|.|||||.|.. |.  | .||...  |  . ......   |
iEDrrse.....akllesngvlfgvfDGHggaacaeavskrLlkyvaasllkkqvleeaekal

subfamily_PP2D1_pd Subfamily PP2D1 115-181 1.9e-06 19.8 In-house 13-78 (492) alignment
Range on Protein: 115-181
Range on HMM: 13-78/492.0
WRICMEDSHIaeaIMSQSSPYKDWSFFAVFDGHAGHHIANRASSQLlEHLISSEEFR---EMTKTLEENN
|.  ||| .    ....  .  . .||...||. |   |. |...|  .....|  .   ... | ..| 
WKskmeDkrt...lqdyfgndvnscFfgiyDGynGataAeiaakel.hevlleelekvdervslttavnl

subfamily_PPM1H_pd Subfamily PPM1H 132-181 5.3e-06 18.4 In-house 56-103 (404) alignment
Range on Protein: 132-181
Range on HMM: 56-103/404.0
SSPYKDWSFFAVFDGHAGHHIANRASSQLLEHLisSEEFREMTKTLEENN
 ..  .  .|..||||||. .|  || .| .||   |........| |..
eeeklplayfglfDGhaGsgaalvaskllhkhl..kekledvlellleks

Subfamily Dicty-PPM1L-like 106-242 9.2e-06 17.7 In-house 8-141 (305) alignment
Range on Protein: 106-242
Range on HMM: 8-141/305.0
RYGMSSMQGWRICMEDSHIAEaIMSQSSpyKDWSFFAVFDGHAGHHIANRASSQLLEHLISseeFREMTK-TLEENNGVLTDSTLKLLEKGIKKGFLSFD
.|..   .. |   || .    |  .||  .. |.| ||||| |.  |. .  .|.| . .   .  . |     .|    |..|. ....  ..  |. 
kyelyvsansrkyqedrnkvk.isless..qelslfGvfdGhnGdiaaeyvkkklveivnk...yvkenkvGysaknlnvddlpleaiksaslstdkssl

EISKTSNdiSKSGCTA----VCAIVTPTHFIIGNLGDSRAVV
. ... |   |.| |        |.    .|  . .|. .|.
dsaesdn..kkaGttlngssasvilerertivstasdtevvl