Gene ppm-2 in Caenorhabditis elegans

Synonym: CELE_T23F11.1, T23F11.1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1Z
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP157_AA protein Get Run
CeleP157_AA_2-286 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1G2_pd Subfamily PPM1G2 4-286 6.3e-140 458.1 In-house 1-286 (287) alignment
Range on Protein: 4-286
Range on HMM: 1-286/287.0
TLSEPVTKKESASCANENYLVGSSCMQGWRVDMEDAHTH---LLSLPDDPKCAFFAVYDGHGGSKVSQYSGINLHKKVVAQKEFSEGNMKEAIEKGFLEL
||||||..||||||||... ||||.|||.|..|||||..   ||...||...|.|||.|||||.||..|.| .|.||....|.|.||.........|||.
tlsepvvakesascanaltkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdaflet

DQQMRVDEETKDDVSGTTAVVVLIKEGDVYCGNAGDSRAVSSVVGEARPLSFDHKPSHETEARRIIAAGGWVEFNRVNGNLALSRALGDFAFKNCDTKPA
|.... ||..||...|.||||||||| ..|..|||||||| |. |... |||||||..|.|..|||||||.||.||||||||||||||||.||....|..
DeellkdeklkdesaGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfvelnrvngnLalsralgDfefkknvkkkp

EEQIVTAFPDVITDKLTPDHEFIVLACDGIWDVMTNQEVVDFVREKLAEKRDPQSICEELLTRCLAPDCQMGGLGCDNMTVVLVGL
|||||||.|||...||..|.||.||||||||||.||.||||.|||.|........|.||||..|||||....|.||||||||.| |
eeqivtavPDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvvivvl

PP2Cc_SM00332 16-284 7.4e-89 290.8 In-house 4-274 (274) alignment
Range on Protein: 16-284
Range on HMM: 4-274/274.0
SCANENYLVGSSCMQGWRVDMEDAHTHLLSLPDDPKCAFFAVYDGHGGSKVSQYSGINLHKKVVAQKEFSEG----NMKEAIEKGFLELDQQMRVDEETK
|  | ..  | |.|||||. |||||   ..|    . .||.|.||||||.|...   .|.. .  .... ..    ...||..|.||..|.... .|. |
sgsnlglsygkssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqsk

DD---VSGTTAVVVLIKEGDVYCGNAGDSRAVSSVVGEARPLSFDHKPSHETEARRIIAAGGWVEFNRVNGNLALSRALGDFAFKNCDtkPAEEQIVTAF
 .    ||.||||.|.|..|.|. |.|||||| .  |.|..|| ||||..|.| .|| .|||.||..||||.||.|||.||...|. .  . .|...|| 
elenalsGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdhflkknk..klkepyitae

PDVITDKLTPDHEFIVLACDGIWDVMTNQEVVDFVREKLAEKR--DPQSiCEELLTRCLAPDcqmgGLGCDNMTVVLV
||| . .||...||..||.||.|||..||||||.||..||..   |||  ..|||.......    | ..||.|||.|
pdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqe.aaelldeeairr....ggseDniTvvvv

subfamily_PPM1A_pd Subfamily PPM1A 18-286 1.3e-87 286.7 In-house 8-280 (282) alignment
Range on Protein: 18-286
Range on HMM: 8-280/282.0
ANENYLVGSSCMQGWRVDMEDAHTHLLSLPDDPKCAFFAVYDGHGGSKVSQYSGINLHKKVVAQKEFS--------EGNMKEAIEKGFLELDQQMRVDEE
 .... .| | ||||||.||||||   ||.  .. .||||.|||.||.|..|.  .|..... ..|..        . ..|||...|||.||...| ...
egnglrygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairelst

TKD--DVSGTTAVVVLIKEGDVYCGNAGDSRAVSSVVGEARPLSFDHKPSHETEARRIIAAGGWVEFNRVNGNLALSRALGDFAFKNCDTKPAEEQIVTA
...  | ||.|||.||..|  ... |.|||||| .  |.|  |. |||||...| .|| .||| |  .||||.||.||||||...|. ..|.|||| |.|
dlktadksGsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDyeykeeeekkaeeqlvsa

FPDVITDKLTPDHEFIVLACDGIWDVMTNQEVVDFVREKLAEKRDPQSICEELLTRCLAPDCQmgglgcDNMTVVLVGL
 |.| . . . ...|.||||||||||....|||..||..|  . ........|. ..|  . .      ||..|..| .
epevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsr......DNlsvlvvlf

0034914 PP2C-like 3-286 3e-83 271.8 In-house 2-290 (295) alignment
Range on Protein: 3-286
Range on HMM: 2-290/295.0
QTLSEPVTKKESASCANENYLVGSSCMQGWRVDMEDAHTHLLSLPD-DPKCAFFAVYDGHGGSKVSQYSGINLHKKVVAQ-------KEFSEGNMKEAIE
..|| |.. . . |  . .. ||....||.|  .|||....|.|.  ......|.|.|||||......   .|.. .. .        ..|. ...||..
lllslpllellllsslllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealr

KGFLELDQQMRVDEET--KDDVSGTTAVVVLIKEGDVYCGNAGDSRAVSSVVGEARPLSFDHKPSHETEARRIIAAGGWVEFNRVNGNLALSRALGDFAF
|.||..|....   .   ....|||||||.||... .|..|.|||||| .  ||...|..||||..|.| .||..|||.| ..||||.||..|||||| .
kaflaadeellelallrpelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdfdl

KNCDTKPAEEQIVTAFPDVITDKLT-PDHEFIVLACDGIWDVMTNQEVVDFVREKLAEKRDPQSICEELLTRCLApdcqmgGLGCDNMTVVLVGL
|.. . ...|..|.|.|||.. .|| .|..|..||.||.|||..|.|.||.||. ||.  |.. ..|||. ..||      . ..||.|||.| |
klllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAla......rgsrDNiTvvvvrl

PP2C Protein phosphatase 2C 24-269 3.1e-82 269.0 Pfam-A 3-251 (255) alignment
Range on Protein: 24-269
Range on HMM: 3-251/255.0
VGSSCMQGWRVDMEDAHTHLLSL---PDDPKCAFFAVYDGHGGSKVSQYSGINLHKKVVAQKEFSEG-NMKEAIEKGFLE-LDQQMRVDEET-KDDVSGT
||.|..||.|  |||||..| .|    .. . |||||.|||||.....| . .|....  ||.|.|. . ..|. |.||. .|.... .... ... ||.
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskantepsksGs

TAVVVLIKEGDVYCGNAGDSRAVSSVVGEAR-PLSFDHKPSHETEARRIIAAGGWVE-FNRVNGNLALSRALGDFAFKNCDtkpaeEQIVTAFPDVITDK
||||.||.. ..|. |.|||||| .  ..|.  |..|||||.| |..|| .|||.|. ..||||.||.||||||| .|. .     ||.|.| ||| . |
tavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePdvtsvk

LTPDHEFIVLACDGIWDVMTNQEVVDFVREKLAEKRDPQSICEELLTRCLAPDC
||...||..||.||.|||...||.||.||..| .|..|. ..|||.. ..|. .
lteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargs

PP2C Protein phosphatase 2C 24-269 3.1e-82 269.0 In-house 3-251 (255) alignment
Range on Protein: 24-269
Range on HMM: 3-251/255.0
VGSSCMQGWRVDMEDAHTHLLSL---PDDPKCAFFAVYDGHGGSKVSQYSGINLHKKVVAQKEFSEG-NMKEAIEKGFLE-LDQQMRVDEET-KDDVSGT
||.|..||.|  |||||..| .|    .. . |||||.|||||.....| . .|....  ||.|.|. . ..|. |.||. .|.... .... ... ||.
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskantepsksGs

TAVVVLIKEGDVYCGNAGDSRAVSSVVGEAR-PLSFDHKPSHETEARRIIAAGGWVE-FNRVNGNLALSRALGDFAFKNCDtkpaeEQIVTAFPDVITDK
||||.||.. ..|. |.|||||| .  ..|.  |..|||||.| |..|| .|||.|. ..||||.||.||||||| .|. .     ||.|.| ||| . |
tavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePdvtsvk

LTPDHEFIVLACDGIWDVMTNQEVVDFVREKLAEKRDPQSICEELLTRCLAPDC
||...||..||.||.|||...||.||.||..| .|..|. ..|||.. ..|. .
lteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargs

PPM_PTC7 24-269 1.5e-81 266.6 In-house 3-255 (259) alignment
Range on Protein: 24-269
Range on HMM: 3-255/259.0
VGSSCMQGWRVDMEDAHTHLLSLP---DDPKCAFFAVYDGHGGSKVSQYSGINLHKKVVAQKEFSEG-NMKEAIEKGFLELDQQMRVDE--ET-KDDVSG
.|.|..||.|. |||||..|  |    .. . |||||.|||||.....| . .|....  .|.| |. . ..|. |.||.||. .. .   .  ... ||
ggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelksseantepstsG

TTAVVVLIKEGDVYCGNAGDSRAVSSVVGEAR-PLSFDHKPSHETEARRIIAAGGWVE---FNRVNGNLALSRALGDFAFKNCDTkpaEEQIVTAFPDVI
.||||.|| . ..|. |.|||||| .  |.|. .|..|||||.| |..|| .|||.|.   ..||||.||.|||.||| .|.  |   ||| |.| ||. 
stAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpket...eeqlvsaePdis

TDKLTPDHEFIVLACDGIWDVMTNQEVVDFVREKLAEKrDPQSICEELLTRCLAPDC
. |.....||..||.||.|||...||.||.||. |..| ||. ..|.|.. ..|...
stkideedefliLasdGlwdvvsdqeavdlvrselskk.dpmeaaeklvdeaiargs

subfamily_PPM1G_pd Subfamily PPM1G 109-286 5.3e-73 239.6 In-house 290-470 (473) alignment
Range on Protein: 109-286
Range on HMM: 290-470/473.0
ETKDDVSGTTAVVVLIKEGDVYCGNAGDSRAVSSVVGEARPLSFDHKPSHETEARRIIAAGGWVE-FNRVNGNLALSRALGDFAFKNCDTKPAEEQIVTA
|..   |||||||.|.|| ...  ||||||.| |  |.|  || ||||  |.|..|| .||| |.   |||| | |||||||.|.|.  . |..||...|
eepGedsGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplkeqmisA

FPDVITDKLTPDHEFIVLACDGIWDVMTNQEVVDFVREKLAEKRDP--QSICEELLTRCLAPDCQMGGLGCDNMTVVLVGL
.||. . .||...||.||||||||.||. ||||||||.||.....   ..|.||||  ||||| .  | |||||||..| |
lPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtviivll

0049733 PP2C-like 24-284 2.5e-56 183.5 In-house 5-231 (235) alignment
Range on Protein: 24-284
Range on HMM: 5-231/235.0
VGSSCMQGW-RVDMEDAHTHllslpddpKCAFFAVYDGHGGSKVSQYSGINLHKKVVAQ-KEFSEGNMKEAIEKGFLELDQQMRVDEET--KDDVSGTTA
|| ....|. |  .|||.          ....|||.|||||. ....   .|.. .... .|... ...||..| ||.......   ..  . ...||||
vgaasdigrvrkvneDavlv........glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallelalaspelagmgtTa

VVVLIKEGDVYCGNAGDSRAVSSVVGEARPLSFDHKPSHETEARRIIAAGGWVefnRVNGNLALSRALGDFAFKncdtkpaeeqivtafPDVITDKLTPD
||.|. .| .|. |.|||||.    |....|..||.|..|.| .|||.|||.|   ||.| |||.|||||. .|               ||| . .|.|.
vvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav...rvpgrlaltralGdlllk...............pdvtvlelepg

HeFIVLACDGIWDVMTNQEVVDFVREklaekRDPQSICEELLTRCLApdcqmgGLGCDNMTVVLV
. |..||.||.|||....|.||..|.      |.. ..|.|. ..||      . |.||.|||.|
d.flllasDGlwdvlsdeeivdllrs.....ldleeaaerlvelala......rggrDNiTvvvv

subfamily_PPM1E_pd Subfamily PPM1E 22-285 3.1e-54 176.9 In-house 4-261 (265) alignment
Range on Protein: 22-285
Range on HMM: 4-261/265.0
YLVGSSCMQGWRVDMEDAHTHL------LSLPDDPKCAFFAVYDGHGGSKVSQYSGINLHKKVVAQKEFSEGNMkEAIEKGFLELDQQMRVDEETKDDVS
| | . .... |  ||| |  |      . | |... |||||.|||||.. ..|.  .||. .| |... |  . ||....| ..|...    | .   |
yevsiaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa.ealkeafkltDerflqkaereklks

GTTAVVVLIKEGDVYCGNAGDSRAVSSVVGEARPLSFDHKPSHETEARRIIAAGGWV---EFNRVNGNLALSRALGDfafkncdtkPAEEQIVTAFPDVI
|.|||||||..  .| .  |||.|.    |||. |   |||..| |..|| .||| |   .  ||||.|..|||.||         . ... |.. .|| 
GstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGD.........vklkpyvsgeadva

TDKLTPDHEFIVLACDGIWDVMTNQEVVDFVREKLAEKR-DPQSICEELLTRCLAPDCQmgglgcDNMTVVLVG
. .|. ..|...|||||.|||....|||. |.| ||..  | ... ..|..     . .      ||.|||.| 
eveldgseeylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagss......Dnitvvvvf

PPM_PTC7_SpoIIE 24-266 6.6e-48 156.5 In-house 3-223 (230) alignment
Range on Protein: 24-266
Range on HMM: 3-223/230.0
VGSSCMQGWRVDMEDAHTHLLSL---PDDPKCAFFAVYDGHGGSKvsQYSGINLHKKVVAQKeFSEGN-MKEAIEKGFLELDQQMRVDeetkDDVSGTTA
.|.|..||.|  |||||...  .   ...   ......|||||.   ..    |.... ... | ...  .|......|.|..... .    ...||.||
ggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrela.faglekpeeilrrlnlalaadlede....psssgaTa

VVVLIKEGD--VYCGNAGDSRAVSSVVgE-ArplsfdhkpshetEARRIiAAGGWVE----FNRVNGNLALSRALGDFAFKNcdtkpaEEQIVTAFPDvI
||.||   .  .|. |||||... .   .               |..|| .|||...    ..||.|.||.|.| ||. ..       ....|.| ||  
vvalidpstgklyvanaGdsppllvrd.dgg.............ereri.vagglpslGilpgrvfgvlavslapGdlllly......tDGvveaepd.t

TDKLTPD-HEFIVLACDGIWDVMTNQEVVDFVREKLAEKrdpqsICEELLTRCLA
 |..... .||..||.||.|||...||.||.||. | ..     ..|.||. ...
sdgelfgkdeflilasdglwdvlspqelvdlvrdelekp.....aaeglleDDit

subfamily_PPM1L_pd Subfamily PPM1L 27-250 5.7e-47 153.2 In-house 10-239 (269) alignment
Range on Protein: 27-250
Range on HMM: 10-239/269.0
SCMQGWRVDMEDAHTHLLSLPDDPKCAFFAVYDGHGGSKVSQYSGINLHKKVVA-------QKEFSE-GNMKEAIEKGFLELDQQMRVDEETKDDVSGTT
 ...| |  |||  .    . .. .  ||||.|||||   ....   | |.. .       .|| .|  | .. ...  | .|...    ... |..|||
ysvlGrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakraediaGtt

AVVVLIKEGDVYCGNAGDSRAVS-SVVGEARPLSFDHKPSHETEARRIIAAGGWVEFN---RVNGNLALSRALGDFAFKNcdtkpaeEQIVTAFPDVITD
|.. |..| |.   | |||| |     |.| |||||||| .  | .||  |||.. |.   ||.| || ||||||. .|.       ...| | ||..| 
alialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkd.......knlviadpdiltf

KLTP-DHEFIVLACDGIWDVMTNQEVVDFVREKLAEK
.|   . ||..||.||.|| ..|.| | |..|.| | 
dlddhkpeflilasdGlwdtfsneeavrfikerlkep

subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 21-263 3.1e-45 147.4 In-house 5-236 (255) alignment
Range on Protein: 21-263
Range on HMM: 5-236/255.0
NYLVGSSCMQGWRVDMEDAHTHLLSLPDDPKCAFFAVYDGHGGSKVSQYSGINLHKKVVAQKEFSEGNMKEAIEKGFLELDQQMrvdeETKDDVSGTTAV
 . || | | | |  |||  .   |  |...  ..|..|||||.. ....  .|.| .    .  . | .....| . |.. |.    . .    ||||.
rfkvgfsdmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeistqi....serpkfiGttaa

VVLIKEGDVYCGNAGDSRAVSS-VVGEARPLSFDHKPSHETEARRIIAAGGWVEFN----RVNGNLALSRALGDFAFKncdtkPaeeqIVTAFPDVI-TD
.||| |  ||  | ||||.| .   | |. ||.|||||.| | .|| ..|| |  .    ||||.||.||||||  ..     |     |.. ||.  . 
svliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsfle.....P....fvvpdPdlsqsl

KLTPDHEFIVLACDGIWDVMTNQEVVDFVreklAEKRDPQSICEELLTR
. . ...|..||||||||.....| |. |    |.  ||.  .|.|   
eiskkdkflilacdGiwdlisdeeaveiv....agisdpekaaeklrdl

subfamily_ILKAP_pd Subfamily ILKAP 27-257 5.8e-40 130.3 In-house 10-253 (293) alignment
Range on Protein: 27-257
Range on HMM: 10-253/293.0
SCMQGWRVDMEDAHTHLLSLPDD--------PKCAFFAVYDGHGGSKVSQYSGINLHKKVVA---QKEFSE--GNMKEAIEKGFLELDQQMRVD--EETK
.. .| | .|.|||. | .| ..         . ...||.|||.||. |...  .||||...   ....|    ..| .. . | . |...     ... 
aerkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefLklaskakP

DDVSGTTAVVVLIKEGDVYCGNAGDSRAVSSVVGEA------RPLSFDHKPSHETEARRIIAAGGWVEFNRVNGNLALSRALGDFAFKNCDtkpaeeqiV
    |.||.|||. .  .| .| |||.||     |.       .|. ||.| .. | .||  ||| |. .||.| |  ||..||  ||..         |
vWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfkrlG........v

TAFPDVITDKLTPDHEFIVLACDGIWDVMTNQEVVDFVREKLAEKRDPQSIC
.. |||   .||..  |.||||||.|.|....|||.|. . | ...| ..| 
istPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrkik

subfamily_PPM1D_pd Subfamily PPM1D 24-286 6.2e-40 130.2 In-house 4-307 (309) alignment
Range on Protein: 24-286
Range on HMM: 4-307/309.0
VGSSCMQGWRVDMEDAHTHLLSLPDDP---KCAFFAVYDGHGGSKVSQYSGINLHKKVVAQKEFSE---GNMKEAIEKGFLELDQQMRVDEE----T---
| |.. || |  |||  .  |.  .     . ||.||.||||| . ...   .| ...  ||.|      .. |||...||.. ..|.   |    |   
vtseadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktksg

KDDVSGTTAVVVLIKEGDVYCGNAGDSRAVSSVVGE------ARPLSFDHKPSHETEARRIIAAGGWVEFN---------R----VNGN--------LAL
.   .|||| ||.|.. ..| .. |||..| .|  .      |..|  ||||.. .| .||  .|| |  .         |     ||.        ||.
llstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngptvideiPFLav

SRALGDFAFKNCDtkpAEEQIVTAFPDVITDKLTPDHE-FIVLACDGIWDVMTNQEVVDFVREKLAEKRD----PQSICEELLTRCLAPdCQMGGLGCDN
.|.|||.   |      .| .|   |||   .|.|..| ||.|| ||.|.|.| ...|..|... . |       .|. . |... |    .   | .||
aRslGDlWsynak...sgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqr.wrskklraDn

MTVVLVGL
..|..| |
vsvivvil

subfamily_PPM1K_pd Subfamily PPM1K 24-284 1.6e-38 125.3 In-house 6-256 (263) alignment
Range on Protein: 24-284
Range on HMM: 6-256/263.0
VGSSCMQGWRVDMEDAhTHLLSLpdDPKCAFFAVYDGHGGSKVSQYSGINLHKKVVAQKeFSEGNMKEAIEKGFLELDQQMRVD-----EETKDDVSGTT
||   ..| | . ||   .|. |  ||.  ..||.|||.||   ..   .|.| .   .   | .... . . |.|||....        |..   ||||
vGkdsliGkraenedr.iklkel..dpellyvavfdGhaGsaaadfvhdklekilkrll.ekekdleivlknafeeldkklkrylefsvaeaellssGtt

AVVVLIKEG-DVYCGNAGDSRAVSSVVGEARPLSFDHKPSHETEARRIIAAGGWVEFN-----RVNGNLALSRALGDFAFKNCDtkpaeeqiVTAFPDVI
| |.|...| ..   . |||||.    |.|. |. ||.|..|.| .|| |||| ||.|     .||| ||..|.|||. .|.          | | |.  
atvsllrdGtelvlaslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryG........viatPetk

TDKL-TPDHEFIVLACDGIWDVMTNQEVVDFVREKlaekRDPQSICEELLTRCLapdcQMGGlgCDNMTVVLV
. |.   .  |.||  ||| .|...||. |.||      .||.   . | .  |    | |    || |.|.|
slkvdhaadsflvlitdgisfvvnsqelcdlvrlc....hdpeeaahalteqal....qygs..ednatavvv

subfamily_PPM1G_pd Subfamily PPM1G 5-111 5.7e-29 94.4 In-house 2-106 (473) alignment
Range on Protein: 5-111
Range on HMM: 2-106/473.0
LSEPVTKKESASCANENYLVGSSCMQGWRVDMEDAHTHLLSLpdDPKCAFFAVYDGHGGSKVSQYSGINLHKKVVAQKEFSEGNMKEAIEKGFLELDQQM
||.| ..|||   .||.  .| | ||||||..||||. .. |  | ....|||||||||..|..|   .| . . ||| . ||....|.|. ||.||...
lskpkvekesedesneelsygasamqGwrvsqEDahncitdl..dedtslfavyDGHGGkevakyvakklpdllkaqkgykegdvekaleeaflalDekl

RVDEETK
. .|  |
kaeeslk

subfamily_KAPP-like_pd Subfamily KAPP-like 33-285 4.8e-25 81.1 In-house 9-265 (266) alignment
Range on Protein: 33-285
Range on HMM: 9-265/266.0
RVDMEDAHTHLLSLPDDPK------CAFFAVYDGHGGSKVSQySGINLHKKVVAQKEFS----EG-----NMKEAIEKGFLELDQQMRvdeetKDDVSGT
 . ||| .     | .. |       |.|||.||| |  ... .  .| .|.. ..  |    .|     .... .|. | |.|....     . .  |.
stemedvslaiypllkekklsncsnialfavfdGhaGkGaad.aakklfpkelekllkstkqddGGdniydqskllenafkevdaklk.....dfeyeGa

TAVVVLIK-EGD---VYCGNAGDSRAVSSVVGEARPLSFDHKPSHETEARRIIAAGGWVEF--NRVNGnLALSRALGDFAFKNCDTKPAEEQIVTAfpdv
|| ..|.  .|.   . ..| ||| |  |   |.  ||.|||  .. | .||   |  .     |.|| ||.||||||   |. .   . |  |.     
tatlalvwsdGqqrylqvanvGdssaflsrGneslelskdhkakdpeekqrikddGitlsdnqtrinG.lavsralGdhfikelniGlisepyvsn....

iTDKLTPDHEFIVLACDGIWDVMTNQEVVDFVREKLAekrdpQSICEELLTRCLApDCQMG-GLGCDNMTVVLVG
    ||| ..|...| ||.|||.. .. .. |.         |   |. .. .|  .. ..  .  ||..|..| 
.rilltpfdkflivasdGlwdvisGkdaiekvkslyd.....qqatedkmassll.etaiqsikakdnvsvivvk

subfamily_PDP_pd Subfamily PDP 75-256 1.1e-24 80.3 In-house 101-321 (398) alignment
Range on Protein: 75-256
Range on HMM: 101-321/398.0
HKKVVAQKEFSEGNMKEAIEKGFLELDQQMRV-----------DEETKDDVSGTTAVVVLIKEGDVYCGNAGDSRAVSSVVG-----EARPLSFDHKPSH
.|.. .. | . ...|||..|.||.||....            .|...  .||..|...||.. ...  |.||.|||  |.      ||..|| |.  . 
skylqelleaevekvkealkkaFlklDkdistealkklkekslreallvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadn

ETEARRIIAAGG------WVEFNRVNGNLALSRALGDFAFKNCD---TKPAEE------Q--------IVTAFPDVITDKLTPDHEFIVLACDGIWDVMT
| | .|| ..         .  .|. |.|. .|| ||. .|       |. |.      .         .|| |.|.. ||...  |.||| ||.||...
eeEveRikkeHPgeesktvirngRlLgeLqPlRAFGdvryKwseelqkkvlekaylkvlepkdyktPPYltaePevtshklrendkFLvlatDGLwdlls

NQEVVDFVREKLAEKRDPQSI
|.|||. | | ||.| . ...
neevvslVgehlakkkekepv

subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 33-285 1.9e-21 69.2 In-house 8-275 (276) alignment
Range on Protein: 33-285
Range on HMM: 8-275/276.0
RVDMEDAHTHLLSLPDDPK------CAFFAVYDGHGGSKVSQySGINLHKKVV----AQKEFS----EGNMKEAIEKGFLELDQQMRVDEETKD-DVSGT
 . ||| .     | |. .       |.|||.||| |  ... .  .|  |..       ..|    .   ..  ..  | ||    ||.. || .  |.
stemedvslaiyplldekdlsncsnialfavfdGhaGkGaad.aakklfpkelekllksgnysltkqddGGdniydqskllldlfkevdaklkdfeyeGa

TAVVVLIK-EG---------DVYCGNAGDSRAVSSVVGEARPLSFDHKPSHETEARRIIAAGGWVEF--NRVNGnLALSRALGDFAFKNCDTKPAEEQIV
|| ..|.  .|          . ..| ||| |  |   |.  ||.||| .   | .||   |  .     |.|| ||.||||||   |. .   . |  |
tatlalvwsdGeeqqqqqqrylqvanvGdssaflsrGneslelskdhkatdpeekqrikddGitlsdnqtrinG.lavsralGdhfikelniGlisepyv

TAfpdviTDKLTPDHEFIVLACDGIWDVMTNQEVVDFVREKLAekrdpQSICEELLTRCLApDCQMG-GLGCDNMTVVLVG
.         ||| ..|...| ||.|||.. .. .. |.         |   |. .. .|  .. ..  .  ||..|..| 
sn.....rilltpfdkflivasdGlwdvisGkdaiekvkslyd.....qqatedkmassll.etaiqsikakdnvsvivvk

subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 54-192 9.2e-21 67.6 In-house 22-185 (292) alignment
Range on Protein: 54-192
Range on HMM: 22-185/292.0
F-FAVYDGHG--GSKVSQYSGINLHKKVVAQKEfSEGNMKEAIEKGFLELDQQMRVDEETKDDVSGTTAVVVLIKEG-DVYCGNAGDSRAVSSV-----V
|  ||.||||  | ||.|..  .| ....        .. ||. .. |..  ...     .   ..|..|   ....  ..  | |||||.         
flaavldGhGvnGdkvaqlaedtlevelleltr.qlqelsealllrildiaakldkltidaresattavvcarvrddralilanvGdsrallgrclggsd

GEARPLSFDHKPSHETEARRIIAAGGWVE-----------FNRV------NGNLALSRALGDFAF
 | .||| ||||.   | .|| .||| ||             ||      .|.|||||||||| .
yeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdfhl

PPM_PTC7_motif 224-269 4.6e-19 61.7 In-house 1-47 (51) alignment
Range on Protein: 224-269
Range on HMM: 1-47/51.0
VLACDGIWDVMTNQEVVDFVREKLAEKR-DPQSICEELLTRCLAPDC
.||.||.|||...||.||.||. |..|. .||...|.| ...||. .
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargs

subfamily_PP2D1_pd Subfamily PP2D1 107-252 1.3e-17 56.7 In-house 168-311 (492) alignment
Range on Protein: 107-252
Range on HMM: 168-311/492.0
DEETKDDVSGTTAVVVLIKEGDVYCGNAGDSRAVSSVVGEARPLSFDHKPSHETEARRIIAAGGWVE----FNRVNGNLALSRALGDFAfkncDtkPAEE
| |   . .  .  | |.. | .|  |||. .||    |.|  |  .| |  . | .|.  ||. |       .||| |   | || .     |  |  .
dseeGlekesngsevhleelgvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyG....d..pkLk

QIVTAFPDVITDKLTPDHEFIVLACDGIWDVMTNQEVVDFVREKLAEKRD
. |   | ... ||.    |.|||  |.|.|....||.  |.. ||  ..
ksvipePkttsvkldeaaqflvlAsnGlWevlseeevlsLvkqtlaiyks

subfamily_PPM1H_pd Subfamily PPM1H 89-165 2.4e-16 52.5 In-house 136-210 (404) alignment
Range on Protein: 89-165
Range on HMM: 136-210/404.0
MKEAIEKGFLELDQQMRVDEETKDDVSGTTAVVVLIKEGDVYCGNAGDSRAVSSVVGEARPLSFDHKPshETEARRI
.. |.|. |||.|.|.. ..|.  .  | ||.|.|. .| .|  |||||||. .  .| .|||.|. |  ||| .|.
viGalesaflemDeqiarereayrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftP..eteRqRl

Subfamily Dicty-PPM1L-like 29-252 1.8e-15 49.6 In-house 14-268 (305) alignment
Range on Protein: 29-252
Range on HMM: 14-268/305.0
MQGWRVDMEDAHTHLLSLPDDPKCAFFAVYDGHGGSKVSQYSGINLHKKV-----------VAQKEFSEGNMKEAIEKGFLELDQQMRVDEETKDDVSGT
 .. |   || .   .|| .. .  .| |.|||.| . ..|.  .| . |            |.   ..    |||....|. |. .    |. .  .||
sansrkyqedrnkvkislessqelslfGvfdGhnGdiaaeyvkkklveivnkyvkenkvGysaknlnvddlpleaiksaslstdkssldsaesdnkkaGt

TA----VVVLIKEGDVYCGNAGDSRAVSSVVGEARPLSFDHKPS---------------------HETEARRIIAAGGWV-EFN--RVNGNLALSRALGD
|       | ..   .   .|.|. .| |  . | .||  . |                       ...  ||  ... . ..   .||. |  ||  ||
tlngssasvilerertivstasdtevvlssGaiaeglsiinsPkgvgfdspgwmkfnhlynqnnfldeiririeslqaalynygellvnrllkksrskGd

FAFKNCDTkPAEEQIVTafpdVITDkltPDHEFIVLACDGIWDVMTNQEVVDFVREKLAEKRD
   |     | ... .     |...   .. .|.||| ||.|.|. .|.||..|.|.| .|  
knlkelvi.Pnndspll....vvak...anDqflvlatdGlwevlsyqdvveevkellrdkss

subfamily_TAB1_pd Subfamily TAB1 105-234 5.2e-14 44.8 In-house 119-260 (333) alignment
Range on Protein: 105-234
Range on HMM: 119-260/333.0
RVDEETKDDVSGTTAVVVLIKEGDVYCGNAGDSRAVSSV---VGEARPLSFDHKPSHETEARRIIAAG---GWVEFNRVNGNLALSRALGDFA----FKN
|. | ...   ||||||.||   ..|  |.|||||.        . . || ||.   | |  |.   |     .. |.. |.    |..||.     .|.
rlqeleeeisgGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkkgykd

CDT-KPAEEQIVTAFPDVITD-KLTPDHEFIVLACDGIWDVM
 |  . |... | | ||..   ....   |.||  ||.   .
vdilssakgePviaePdiqgaypiddityflvlmSdGvyktL

PP2C_SIG_SM00331 52-284 1.3e-10 34.2 In-house 30-215 (217) alignment
Range on Protein: 52-284
Range on HMM: 30-215/217.0
CAFFAVYDGHGGSKVSQYSGINLHKKVvaQKEFSEGnmkEAIEKGFLELDQQMRVDeeTKDDVSGTTAVVVLI--KEGDVYCGNAGDSRAVSSVvgeARP
  ...| ||.|. . ..     |....  ....|||   |.... . .|.. ..    .... ...|... |.  ..| ..  |||||| .       . 
rlllvvaDgmGkGlaAaaassqlrtal..rellseg...eelsqalkrlnraiyee..keekgmfaTlllalydfssgklsyanaGdsrpyllr...dgk

LSFDHKPshetearriiaaggwvefnrvngnlALSRALG-----DfafkncdtkpaeeqivtafPDVITDKLTPdHEFIVLACDGIWDVMTN-----QEV
| ...|                           ....||     .                   .|. . .| .  ....|. ||......      ...
lveilkd.........................vegaplGlepevs...................vdirelelek.gdllllytDGltearsekgfaeerl

VDFVREKL-AEKRDPQS-ICEELLTRCLAPDCqmgglgCDNMTVVLV
 .......  |... .. | ||||..  ..         |..|||.|
eeiledlvdseaqelaqkiveellelakgsng......eDdiTvvvv

subfamily_PPM1H_pd Subfamily PPM1H 175-251 1.3e-10 33.6 In-house 275-355 (404) alignment
Range on Protein: 175-251
Range on HMM: 275-355/404.0
NRVNGNLALSRALGDFAFKNCDTKPAEEQIVTAFPDVITDKLTP----DHEFIVLACDGIWDVMTNQEVVDFVREKLAEKR
.|. . .. .| |||   | .||.     .....|.| .  ||     . . ..|| ||.|||..|.||   ||| |..  
aRllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskve

PPM_PTC7_SpoIIE_motif 221-284 2.1e-10 34.1 In-house 13-78 (81) alignment
Range on Protein: 221-284
Range on HMM: 13-78/81.0
EFIVLACDGIW-------DVMTNQEVVDFVREKlaEKRDPQSICEELLTRCLApdcQMGGLGCDNMTVVLV
. ..|..||..       ......|.......   |....|.....|. ..|.   . .|   |..|....
dvllLyTDGltEardsdgelfgkeellrladra..egkslqeladklvdevle...ngsgereDDitllvl

PP2C_2 Protein phosphatase 2C 48-254 9.8e-09 27.8 Pfam-A 20-202 (212) alignment
Range on Protein: 48-254
Range on HMM: 20-202/212.0
DDPKCAFFAVYDGHGGSKVSQY-------SGINLHKKVVAQKEFS-EGNMKEAIEKGFLEL---DQQMRVDEETKDDVsGTTAVVVLIKEGDVYCGNAGD
.. .. ..|| ||.|  | |.        . ..  .| ....... |  . ..||.. |..    |.   ..|. .|. .|| ....|..| ..... ||
easdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdy.atTlllavitpgeivffqiGD

SRA-VSSVVGEARPLSFDHKPSHETEARRIIAAGGWVEFnrvngnlalsralgdfafkncdtkpaeeqivtafpDVITDKlTPDHEFIVLACDGIWDVMT
... |..  ||...|. ...  .. | ...  .  . |.                                   .... | ... . ..|  ||..| ..
gaivvrdrdgevqllgepdsgeyanettfltsedaeeel...................................rirrlk.lepgdalllmTDGvsdslr

-NQEVVDFVREKLAEKRDPQ
 .... ....| |.. ....
keepfrellaelletleeeg

PP2C_2 Protein phosphatase 2C 48-254 9.8e-09 27.8 In-house 20-202 (212) alignment
Range on Protein: 48-254
Range on HMM: 20-202/212.0
DDPKCAFFAVYDGHGGSKVSQY-------SGINLHKKVVAQKEFS-EGNMKEAIEKGFLEL---DQQMRVDEETKDDVsGTTAVVVLIKEGDVYCGNAGD
.. .. ..|| ||.|  | |.        . ..  .| ....... |  . ..||.. |..    |.   ..|. .|. .|| ....|..| ..... ||
easdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdy.atTlllavitpgeivffqiGD

SRA-VSSVVGEARPLSFDHKPSHETEARRIIAAGGWVEFnrvngnlalsralgdfafkncdtkpaeeqivtafpDVITDKlTPDHEFIVLACDGIWDVMT
... |..  ||...|. ...  .. | ...  .  . |.                                   .... | ... . ..|  ||..| ..
gaivvrdrdgevqllgepdsgeyanettfltsedaeeel...................................rirrlk.lepgdalllmTDGvsdslr

-NQEVVDFVREKLAEKRDPQ
 .... ....| |.. ....
keepfrellaelletleeeg

subfamily_PP2D1_pd Subfamily PP2D1 31-81 3.4e-08 25.6 In-house 12-62 (492) alignment
Range on Protein: 31-81
Range on HMM: 12-62/492.0
GWRVDMEDAHTHLLSLPDDPKCAFFAVYDGHGGSKVSQYSGINLHKKVVAQ
 |. .|||..|      .|.. .||..|||. |.   . .  .||. .. .
rWKskmeDkrtlqdyfgndvnscFfgiyDGynGataAeiaakelhevllee

subfamily_PHLPP_pd Subfamily PHLPP 53-246 1.2e-06 20.7 In-house 28-215 (246) alignment
Range on Protein: 53-246
Range on HMM: 28-215/246.0
AFFAVYDGHGGSKVSQYsGINLHKKVVAQKEFSEGNMKEAIEKGFLELDQQMRVDEETkddvSGTTAVVVLIKEGD--------VYCGNAGDSRAVSSVV
| . ..||.  ...|.    .| |.|.. .   . | .| ... .|   ...  . |      |..|...||..          .   . |   ||    
alyGlfdGdrneelssl.lqrlmkdvlkeevqkdkneeeymkntllvaqrklGeaGek....lgsaallilirhdkvdPaksfsLevAsvGtlqavliRn

GEARPLSFDHKPSHEtEARRIIAAGGWV-EFNRVNGNLALSRALGDFAfkncdTKPaeeqIVTAFPDVITDKLTPDHEFIVLACDGIWDVMTNQEVVDFV
|.  .||  .. ... |..||  | . . | |..|| .. .| || .      . |    .|   | |   .||.. |....  . .|.|.  .|.|. |
gkklrlsksyviekd.elkrikeakaiitednkingviestrllGytf.....lfP....vvlPkphvrevlLteqdellivGnkalWevlsideaveav

REK
|..
rke

subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 212-247 3.8e-06 19.6 In-house 239-273 (292) alignment
Range on Protein: 212-247
Range on HMM: 239-273/292.0
ITDKLTPDHEFIVLACDGIWDVMTNQEVVDFVREkL
.  .|  | .|.||| ||. ||..|.||| .. .  
lekeldsddaflvlasdGvldvllnaevvlllak.s