Gene R08A2.2 in Caenorhabditis elegans

Synonym: CELE_R08A2.2, CELE_R08A2.2

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily CelePPP-sf3
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP170_AA protein Get Run
CeleP170_AA_19-309 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 21-310 4e-187 613.1 In-house 1-290 (290) alignment 
Range on Protein: 21-310
Range on HMM: 1-290/290.0
KRMIEHLLKWGVTDAFNDKQIYTILEKAESTLNPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVKFLFLGDYVDRGAKSFEVSLLLFCYKIRY
|||||||||.||.|||.||.|..||||.|..|.||||.|.||.||.||||||||||||.|||||||||||||||||||||||||||.|||||||||||||
krmiehllkygvldafsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiry

PHSVHLLRGNHECMKMNRLYGFYEELARKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPLTCDEGLQVDLMWADPTQD
...|||||||||..|.||||||.||||||||.|.|.|||.||.||.||||||..||||||||||...||||.||||||..||||||||||||.|||||.|
skkvhllrgnhevrkvnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrd

KCNTFAMNKQRAISVVFGEKGLDVFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSESYEISFTVLRPRM
|..|.|.|||||||||||.||||..||||.||||||||||..|||||||.||.|||||||||.|||||.|||..||||.|.|..||.||.
kddtialnkqraisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkprk
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 27-309 1.9e-167 548.3 In-house 1-282 (287) alignment 
Range on Protein: 27-309
Range on HMM: 1-282/287.0
LLKWGVTDAFNDKQIYTILEKAESTLNPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVKFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHSVHL
|||.||.|||.||.|...|||.|..|.||||.|.||.|||||||||||||.|.|.|.|||..|||..|||||||||||||.|||||||..||.||..|||
llkygvldafsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhl

LRGNHECMKMNRLYGFYEELARKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPLTCDEGLQVDLMWADPTQDkCNTFA
||||||..|.|.||||.|||.|||..|...|...||.||||||||..||||||||||....|..|.||||||.|||.|||||||||.||||..| ..||.
lrGnhevkkinklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekd.aktfe

MNKQRAISVVFGEKGLDVFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSESYEISFTVLRPR
.||.||||||||.|..| .||||...|||||||||.||..|||.|..|||||||||.|.|||.||...||.|.|.||.||.| 
lnkiraisvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkpe
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 21-310 7.3e-102 333.4 In-house 9-295 (298) alignment 
Range on Protein: 21-310
Range on HMM: 9-295/298.0
KRMIEHLLKWGVTDAFNDKQIYTILEKAESTLNPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVKFLFLGDYVDRGAKSFEVSLLLFCYKIRY
. ..  | .  .| . ..... ...|.|.. ..  .....|. ||.. ||||||   |.| ||  |.||.. .|||||||||| ...|| .||..||..|
evlsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvky

PHSVHLLRGNHECMKMNRLYGFYEELARKR-GGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPltCDEGLQVDLMWADPTQ
|. . |||||||| ..|| ||||||  |.    |.. ..|.||| |||.| .|.||||||||.|.. .|......||.|  .   .| |..||.||||..
pnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfds..keeslaidllwadpen

DKcNTFaMNKQRAISVVFGEKGLDVFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSESYEISFTVLRPRM
 . . . ....| .||||||. .  .|.|| . |.|||| | |.|..|. .|| ||.||||.|||. .|. |.|.|.|  ..||.||.|..
av.kgw.aensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpek
PP2Ac_SM00156 37-309 4.6e-99 323.9 In-house 2-270 (271) alignment 
Range on Protein: 37-309
Range on HMM: 2-270/271.0
NDKQIYTILEKAESTLNPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVKFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHSVHLLRGNHECMKM
........||.... |.  .....|..|.|.||||||||| |.| ..  |.||. |..||||||||| .| || ||||..||.||  |.|||||||. ..
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

NRLYGFYEELARKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKpnTPLTCDEGLQVDLMWADPtQDKCNTFAMNKqRAISVV
|..|||.||..|| | ...   ...|. |||.| |...|||||||.|.. .|..... ||.     ...|||..||.|.|| ..| ..|...| | .|||
nkiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkr..vkekpeegllidllwsdp.eqkekgfqpsk.rglsvv

FGEKGLDVFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSESYEISFTVLRPR
|||. .. ||||. |.||.|||||..||..| ..||.||.||||.||.. .| .|...|... ..|. .|.. 
FgedavkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq
subfamily_PPP1C_pd Subfamily PPP1C 36-309 2.3e-97 318.6 In-house 10-279 (282) alignment 
Range on Protein: 36-309
Range on HMM: 10-279/282.0
FNDKQIYTILEKAESTLNPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVKFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHSVHLLRGNHECMK
.. ..| ..|.||.. |   |..|..|.|..||||||||.  |.|.|.. |.||. ..|||||||||| .| |. .||..|||.||....|||||||...
lkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesas

MNRLYGFYEELARKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTplTCDEGLQVDLMWADPTQDkCNTFAMNKqRAISV
.||.||||.|  |. . ..|.....||| |||.| | ..|||.|||.|.. .| |  . ...| .    ..|| .||.|.|| ..  .... |. | .|.
inriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPle..vpekgllcdllWsdpdke.vlgwsend.rGvsf

VFGEKGLDVFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSESYEISFTVLRPR
.||.. .. ||.|  |.||||||.| ..|..|  ... ||||||| |||.  |.||...|.|.  .||..|.|.
tfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpa
0045823 Metallo-dependent phosphatases 21-309 1e-91 301.0 In-house 31-324 (473) alignment 
Range on Protein: 21-309
Range on HMM: 31-324/473.0
KRMIEHLLKWGvtdAFNDKQIYTILEKAESTLNPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVKFLFLGDYVDRGAKSFEVSLLLFCYKIRY
...||||.|.|    .. .... .|..| . |.  | .|... .|...||||||||.|.| .. .|.||. ...||||.||||  | || .||...||.|
dlliehlkkeg...llpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkiky

PHSVHLLRGNHECMKMNRLYGFYEELARKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPLTcdEGLQVDLMWADPtQD
|..|.|||||||.. .| ||||..|. .| | ........... |||.|..|..||..|||.| . ....  .....|.....  .|| .||.|.|| ..
pgnvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipd..dgllldllwsdP.we

KCNT------FAMNKQRAISVVFGEKGLDVFLKKLGLSLIVRAHEVSQEGFNFLFNKK------CVTVFSAPYYCGNDTNCGAIMHVSESYeISFTVLRP
.. .      | .| .| ....||..... |||| || ||||.|.. .||...||..|      ..|||||| |||.  |..|.....|   |||....|
ddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdp

R
 
s
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 34-310 9.2e-90 293.6 In-house 4-276 (280) alignment 
Range on Protein: 34-310
Range on HMM: 4-276/280.0
DAFNDKQIYTILEKAESTLNPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVKFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHSVHLLRGNHEC
   .. .|....|| .  |    .|..|. |....||.|||   |.| |. |..||  ..|||||||||| . .|| |||..||.||| .  .||||||.
acikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhev

MKMNRLYGFYEELARKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPltCDEGLQVDLMWADPTQdKCNTFAMNkQRAI
...|| |||..|  |.    .. ..|.....|||.| |. ||||||||.||.  |.. .. |..|  .   || |. ||.|||| . |   .| | .| .
isinrkygfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfds..edeclamdllwadpen.kvtgwaen.srgv

SVVFGEKGLDVFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSESYEISFTVLRPRM
||.||.. .  . .|| . ||.| |.| |.|..|. .|| ||||||| |.|. .|  |.. |.|  ..|| ||.| .
svifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpal
PPP_3 37-306 2.4e-89 291.9 In-house 3-269 (271) alignment 
Range on Protein: 37-306
Range on HMM: 3-269/271.0
NDKQIYTILEKAESTLNPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVKFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHSVHLLRGNHECMKM
. ........|... |.  . ......|.|..|||||||| |.. |. .| .|. |.||||||||||.||.|| |||...||.||..|||||||||. ..
senelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrqi

NRLYGFYEELA-RKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPltCDEGLQVDLMWADPTQDKcnTFAMNKQRAISV
|..|||..|.  .| | ..... |.||. |||.| . ...|..|||.|....|... | |.....   ..||. .||.. ......  ..  |..| ...
nkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkiev..peegklldlllssdpeke..eglenskrGagl

VFGEKGLDVFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSESYEISFTVL
.||..  . ||.|  |.||.||||. .||...|...|.||||||| ||.. .| |||....|. . .|..|
lFgpdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkql
0049330 Metallo-dependent phosphatases 20-308 6.2e-87 284.6 In-house 17-298 (309) alignment 
Range on Protein: 20-308
Range on HMM: 17-298/309.0
AKRMIEHLLKWGVtdaFNDKQIYTILEKAESTLNPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVKFLFLGDYVDRGAKSFEVSLLLFCYKIR
 ...||.|||...   .. ......|.|| . |   | .|.....|...||||||||.|.| ....|.||  ...||||.||||  | || |||...|..
ldllielllklkl...lseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkll

YPHSVHLLRGNHECMKMNRLYGFYEELARKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPLTCdeGLQVDLMWADPtQ
||..|.|||||||.. .|.||||..|. || | ..|........ |||.|..|..|||.|||.| . ........|..| ..     || .||.|.|| .
ypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipld..gllcdllwsdp.l

DKCNTFAMNKqRAISVVFGEKGLDVFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSESYEISFTVLRP
. ...||.|. | ..||||.  .. ||||.||.||.|.|.. ..|. ..|..|..|||||| |||.  |.||.....|...|||....|
piregfapnp.rglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfep
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 17-309 1.5e-86 283.4 In-house 4-294 (299) alignment 
Range on Protein: 17-309
Range on HMM: 4-294/299.0
DQLAKRMIEHLL-KWGVTDAFNDKQIYTILEKAESTLNPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVKFLFLGDYVDRGAKSFEVSLLLFC
|.|  ....    .  .| . ..... |. . | |..   ...|.|| || ..||||||   |.| ||  |.||.|.||||||||||| . .|.  ||.|
dellskllnvgmsekrltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllc

YKIRYPHSVHLLRGNHECMKMNRLYGFYEELARK-RGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPLtcDEGLQVDLMW
.||.||.  ..|||||||  .||.||||||  .. .  |.|  .|. |. .||.  .| ||||||||.| . .. . .. | .|. |   .  |..||.|
fkikyperffmlrgnhecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdpp..npslgidllw

ADPTQDKCNtFAMNkQRAISVVFGEKGLDVFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSESYEISFTVLRPR
||| |   . .  |  | .| |||.. .   ...|.. |. |||.| |.|..|. .|| ||.||||.|||.  |  |||.| |    .|.||.| 
adpdqsvkd.wlan.vrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkpt
PPP_1 38-295 6.2e-81 264.5 In-house 3-264 (264) alignment 
Range on Protein: 38-295
Range on HMM: 3-264/264.0
DKQIYTILEKAESTLNPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVKFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHSVHLLRGNHECMKMN
 ........|... ||  . .|.|...||..||||||.| |.. | . | .|. ..|||||||||| .|.|. |||...|..||....|||||||. ...
eeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvt

RLYGFYEELA-RKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALK----KPNTPLTCDE-GLQVDLMWADPTQDKcnTFAMNKQR
. |||..|.  .| . .... ...||. |||.| . ..||..|||.|.. .. .. . ..     |..  .||.   .|| .. |.....  ..  | .|
kvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqe..eavansiR

AISVVFGEKGLDVFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHV
 .. .||..  . ||.| .|.||.||||| .||..||...|.||.|||. |. . .| ||....
GagylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvkl
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 39-310 1.1e-80 264.1 In-house 6-275 (284) alignment 
Range on Protein: 39-310
Range on HMM: 6-275/284.0
KQIYTILEKAESTLNPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVKFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHSVHLLRGNHECMKMNR
... |.| .| | .|  | ...|. || |.||||||.  |.| ||  |.| . ..|||||||||| . .|  ||||.||. .|  . .|||||||  .|.
edvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslink

LYGFYEELARKR-GGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPLTcDEGLQVDLMWADPTQDKcNTFAMNkQRAISVVF
 ||||||  |.     ..  .. || ..|| | |||||||||||.|.  .    ..|.|.|       . | .|..|.|||. . . .  |  | .| ||
iygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpe.pntlaidilwsdptnfq.kgwnpn.srgvsyvf

GEKGLDVFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSESYEISFTVLRPRM
|   |  .| .| . |.||||.| |.|..|. |.. ||.||||.|||.  |. |.|.| .    || ||||| 
gsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrprk
0053225 Metallo-dependent phosphatases 22-309 2.6e-80 262.9 In-house 11-291 (293) alignment 
Range on Protein: 22-309
Range on HMM: 11-291/293.0
RMIEHLLKWGVtdaFNDKQIYTILEKAESTLNPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVKFLFLGDYVDRGAKSFEVSLLLFCYKIRYP
..||.||.. .   .. ......|..| . |   | .|... .|...|||||.||.|.. .. .|.||  ...||||.||||  | || .||...|..||
llielllllkl...lseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllyp

HSVHLLRGNHECMKMNRLYGFYEELARKR-GGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPLtcDEGLQVDLMWADPTqd
..|.|||||||.| .| ||||..|  ||  . ..|........ |||.|..|..||..|||.| . ..... . ...|  .   .|||  ||.| ||.  
dnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplrip..legllldllwsdpd..

KCNTFAMNKQRAIsVVFGEKGLDVFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSESYEISFTVLRPR
  ....... ... ||||.  .. |||| || ||.|.|.| ..|. ..|..|.||||||| |.|  .|.||.....|.. ..|....|.
lwsgwlpsyrglg.vvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapv
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 34-309 5.2e-79 258.6 In-house 6-283 (284) alignment 
Range on Protein: 34-309
Range on HMM: 6-283/284.0
DAFNDKQIYTILEKAESTLNPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYP------PKVKFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHSVHLL
. ...|... .  .|  ..   .  |..| |..|||||||| . |.  .|  |.|       . |.||||||||||  | || .|||.||...|. | ||
kllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfll

RGNHECMKMNRLYGFYEELARKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTplTCDEGLQVDLMWADPTQdKCNTFAm
|||||   .|. ||||.|  ..   ...  .|  || .|||| |...|.|||||||..  . . ...|..|    . | |.  || |||| . . .... 
rgnhesrpvnmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpid..ipdigviadltwadpea.evegyk.

NKQRAISVVFGEKGLDVFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSESYEISFTVLRPR
. .|    |||.| .. ||||  | |.||||.| ..|..|. ..| ||.||||.|||.  | .|...|.|  ..|||||.| 
esprgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkpd
subfamily_PPZ_pd Subfamily PPZ 37-308 2.6e-78 256.5 In-house 26-293 (300) alignment 
Range on Protein: 37-308
Range on HMM: 26-293/300.0
NDKQIYTILEKAESTLNPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVKFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHSVHLLRGNHECMKM
....|  |  ||   .   ||.|..  .. ||||.|||   |.| |  .|.||. ..|||||||||| .|.|  |||.||||.||  . |||||||| ..
knseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecanv

NRLYGFYEELARKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTplTCDEGLQVDLMWADPTqDKCNTFAMNkQRAISVV
 |.||||.|  |.   ..|. . . || |||.| |  .|.|.|||.|   || .  . . .|      | ||  ||.|.||| |  | .  | .| .| .
trvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptd..vpdfglindllwsdpt.dssnewedn.ergvsyc

FGEKGLDVFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSESYEISFTVLRP
. .  .. ||.|.|. |..||| | ..|..|. ..  ||||||| |||.  | ||.| |||    || .| |
ynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldp
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 38-309 1.3e-76 250.5 In-house 10-277 (281) alignment 
Range on Protein: 38-309
Range on HMM: 10-277/281.0
DKQIYTILEKAESTLNPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVKFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHSVHLLRGNHECMKMN
...| ... ..|. .    |. ....||..|||.|.| . |.| |. .| .|. ...||||||||| .|.|| .|||..||||.. . |||||||  ..|
keeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvn

RLYGFYEELARKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPLtcDEGLQVDLMWADPTQDKCNTFAmnKQRAISVVF
. ||||.|   | |  .| ..|. ||.||. | . .|.||||||.| .  . .  .   ||  .|  | || .||.||||...  . .|    | .| .|
kiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnl..drGlviDllwadpdnkveewka..ssrGssftf

GEKGLDVFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSESYEISFTVLRPR
|.. .|   |.|.. ||.||| | |.|.. |  .| .||||.| ||   .|..|.. | |. .||.  | | 
GknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpa
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 35-309 3.9e-75 245.9 In-house 22-295 (297) alignment 
Range on Protein: 35-309
Range on HMM: 22-295/297.0
AFNDKQIYTILEKAESTLNPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVKFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHSVHLLRGNHECM
   ....  .|. | . ..   .|..|. || ..||||||.  |.| |   |.||  ..||||||||||  | |  .||..||...|  . |||||||| 
viteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhece

KMNRLYGFYEELA-RKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPLTCDEGLQVDLMWADPTQDKCnTFaMNKQRAI
 .|. ||||||   | .  ||.  .|.||| |||.  . ..|||||||.|       ....|.| . .    |.|  ||.||||       | |..||  
fvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierstegkerlvadllwadpisgls.gf.menqrga

SVVFGEKGLDVFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSESYEISFTVLRPR
 . ||   .     .. | |..|||.| |.|..|.  .| ||.||||.|||.  || |.| . |  . || .||| 
gcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilrpt
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 91-309 3e-73 239.8 In-house 101-315 (317) alignment 
Range on Protein: 91-309
Range on HMM: 101-315/317.0
VKFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHSVHLLRGNHECMKMNRLYGFYEELARKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWE
 |.||||||||||  |.|| .|||..|..||. |.|||||||   .|. ||||.|  ..   ...  .|..|| ||||| |...|||||||||..  . .
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldlk

SFKALKKPNTplTCDEGLQVDLMWADPTQDkCNTFAmNKQRAISVVFGEKGLDVFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCG
 ...||.|    . | |.  || |||| ..  .... . .|  . |||.| .. ||||| | |.||||.| ..|..|. ..| ||.|||| |||.  | .
qldklkrpld..ipdvGvladltwadpdae.vkgyk.esarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldnia

AIMHVSESYEISFTVLRPR
|...| .  .||..|||| 
avlsvdkklkisinvlrpe
subfamily_PPP4C_pd Subfamily PPP4C 22-306 1.9e-69 227.1 In-house 5-282 (288) alignment 
Range on Protein: 22-306
Range on HMM: 5-282/288.0
RMIEHLLKwgvTDAFNDKQIYTILEKAESTLNPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVKFLFLGDYVDRGAKSFEVSLLLFCYKIRYP
|.||.| .   ..  ..... .. .||.  |     . .|. |.|. ||||||.  |.. |.  |  |. ..|||||.||||  | |  ||| ..|.|||
rqieklrr...celikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvryp

HSVHLLRGNHECMKMNRLYGFYEELARKRGG-RMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTplTCDEGLQVDLMWADPTQD
  ..|.|||||. .. . ||||.|  || |  ..||   .||. |.|.| . ..|.|.|||.| . .. .  ... . .     .||  .||.|.|| . 
dritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqe..vphegplcdllwsdpeda

KcnTFAMNkQRAISVVFGEKGLDVFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSESYEISFTVL
.  ..|.   |    .||..  . | .. ...||.|||.. .||... ||.| .||.||| ||    |  ||... |. .  |...
e..gwavs.prgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkif
subfamily_PPP5C_pd Subfamily PPP5C 10-304 2.2e-69 226.9 In-house 5-304 (322) alignment 
Range on Protein: 10-304
Range on HMM: 5-304/322.0
LYEGESVDQ--LAKRMIEHLLKWGV-TDAFNDKQIYTILEKAESTLNPLPAMLQVEHP----ITIVGDIHGQLDALIRYFDAVGYPPK-VKFLFLGDYVD
 |.| ....  ..| ....||..    .... | ...|| .|.. |. ||........    .|. ||||||   |.  |.  |.| .   .|| ||.||
sydgpkleeekitkefvkellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvd

RGAKSFEVSLLLFCYKIRYPHSVHLLRGNHECMKMNRLYGFYEELARKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGI-SQNCNSWESFKALKKPNT
||. |.|| |.|...|. ||....| |||||  .||.|||| .|   |   ..   ...||| |||.  . ...| .|||. |..  . . .. ... . 
rGsfsveviltllgfkllyPnhfflsrGnhesdnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaq

PltCDEGLQVDLMWADPTQDKCNtfaMNKQRAISVVFGEKGLDVFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHV-SESY
|   .||| |.|.|.|| . .     .. .| ..| ||    . |||. .|.||.|.||| .||...  . |..|||||| || . .| ||.... ..  
p..peegllvellwsdpqeanGr...spskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddl

EISFT
.. |.
klkfk
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 39-309 3.2e-68 223.2 In-house 9-275 (280) alignment 
Range on Protein: 39-309
Range on HMM: 9-275/280.0
KQIYTILEKAESTLNPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVKFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHSVHLLRGNHECMKMNR
..| .|.   |. .     . . | || ..|||| | . . | || .|  |. |..||||||||| .  || .|||| ||||   ..|||||||   .|.
heiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnk

LYGFYEELARKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPLtcDEGLQVDLMWADPTQDKCNTFamNKQRAISVVFG
.|||| |   | |  .| ..|..|| .|... . .|.||||||.| .    .. . . .|  ||  | || .||.|.|||.     |     |.|| .||
iygfyvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepl..drgllidllwsdptnkgegwf..hsirgisymfg

EKGLDVFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSESYEISFTVLRPR
.  ..   | | . ||.|||.| |.|....  .. .|||| | || . ||. |.. .    ..||  | | 
kgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlipp
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 57-309 3.2e-67 220.0 In-house 1-256 (263) alignment 
Range on Protein: 57-309
Range on HMM: 1-256/263.0
AMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVKFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHSVHLLRGNHECMKMNRLYGFYEELARKRG-----
|.|... || |.|| ||| . |.| |.|.|   | ..|||||||||| .|.|| .|||  |.  |. .||||||||   .|. |||. || ..       
allelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevy

GRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPlTCDEGLQVDLMWADPTQDkCNTFAMNKQRAISVVFGEKGLDVFLKKLGL
  .. ....||. .|||| | .||||||||||   .| .  .|.  |    .    | .||.|||| .| .. |  || |||| |||.| .| . |.| .
esvynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplplet.akthplacdllwadpekd.akgfepnkiraisnvfgkkevddlckrldi

SLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSESYEISFTVLRPR
 ||||||.| . |. |. ... .|||||  |  .  |  |.. | .  |.||  |.| 
dlivrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkpe
subfamily_PPP3C_pd Subfamily PPP3C 9-297 1.7e-66 217.8 In-house 18-311 (452) alignment 
Range on Protein: 9-297
Range on HMM: 18-311/452.0
DLYEGESVDQlAKRMIEHLLKWGVtdaFNDKQIYTILEKAESTLNPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVKFLFLGDYVDRGAKSFE
.... ... .  . . ||.|| |    ......  |.|.| . |.  ...|.|| |||..||||||   |.. |.  | | . |.||||||||||. |.|
evfdetgkpk.levlkehflkegr...leeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsie

VSLLLFCYKIRYPHSVHLLRGNHECMKMNRLYGFYEELARKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPltCDEGL
. | |.. || ||....|||||||| ..   . | ||.  | . ... .. . |. ||| | . |. ||.|||.| . .| .. | |.. . |     |.
cvlylyalkiaypstlfllrGnhecrhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkep..pasGp

QVDLMWADPTQDK-----CNTFAMNKQRAISVVFGEKGLDVFLKKLGLSLIVRAHEVSQEGFNFLFN------KKCVTVFSAPYYCGNDTNCGAIMHVSE
  ||.|.||..|       ..|  |. |  |.... |    ||.|  |  |.||||. ..|..   .         .|.|||| |..  .| .|.... .
lcdllWsdPledygeekteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyen
subfamily_PPP2C_pd Subfamily PPP2C 33-307 3.8e-66 216.2 In-house 14-284 (290) alignment 
Range on Protein: 33-307
Range on HMM: 14-284/290.0
TDAFNDKQIYTILEKAESTLNPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVKFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHSVHLLRGNHE
.. ...... .. |||.  |.    . .|. |.|..||.|||.  |.  |   |  |. ..||||||||||  | |   || . |.||.. . .||||||
ckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhe

CMKMNRLYGFYEELARKRGG-RMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTplTCDEGLQVDLMWADPTqDKcNTFAMNkQR
  .. ..||||.|  || |   .|. . ..|. |||.| | ..|.|.|||.| . .. .  .||.. .     .||  .||.|.||  |. . ...  .|
srqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqe..vphegplcdllwsdpd.dr.ggwgis.pr

AISVVFGEKGLDVFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSESYEISFTVLR
     ||..  . | |. ||.||.|||..  ||.|...... ||.|||| ||    | .||. . .... ||    
gagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfd
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 36-308 9.2e-65 211.8 In-house 6-299 (302) alignment 
Range on Protein: 36-308
Range on HMM: 6-299/302.0
FNDKQIYTILEKAESTLNPLPAMLQVEHPITIVGDIHGQLDALIRYFDA------------VGYPpKVKFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHS
.. .......|. ...|.   .. ..  |.||||||||| . |.| . |            ...  . ||.||||||||| || |   |.|..|. ||. 
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfs.sdkfvflGdyvdrGsksieciclvfalkvlyptn

VHLLRGNHECMKMNRLYGFYEELA----RKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPLTcDEGLQVDLMWADPTQ
  |||||||.  .|  ||| |||     .| | ..|.....||  .|| | ||..|||.|||||.. .|.|. | .|.| . .| .. |  ||..|||..
yillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevt.edslaqdllfadpld

-------DKCNTFAMNKQRAISVVFGEKGLDVFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSESYEISFTVLRP
        .   .| |  |..|||| |  .  . |.|.|.|||||| .  |||.|  .|| .|.|||| |  .  | ||...|    ..| .|||.
vqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrn
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 36-308 1.5e-64 211.0 In-house 7-300 (302) alignment 
Range on Protein: 36-308
Range on HMM: 7-300/302.0
FNDKQIYTILEKAESTLNPLPAMLQVEHPITIVGDIHGQLDALIRYFDA------------VGYPpKVKFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHS
.. .......|. ...|.   .. ..  |.||||||||| . |.| . |            ...  . ||.||||||||| || |   |.|..|. ||. 
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfs.sdkfvflGdyvdrGsksieciclvfalkvlyptn

VHLLRGNHECMKMNRLYGFYEELA----RKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPLTcDEGLQVDLMWADPTQ
  |||||||.  .|  ||| |||     .| | ..|.....||  .|| | ||..|||.|||||.. .|.|. | .|.| . .| .. |  ||..|||..
yillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevt.edslaqdllfadpld

-------DKCNTFAMNKQRAISVVFGEKGLDVFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSESYEISFTVLRP
        .   .| |  |..|||| |  .  . |.|.|.|||||| .  |||.|  .|| .|.|||| |  .  | ||...|    ..| .|||.
vqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrn
PPP_2 65-260 7.8e-63 204.7 In-house 1-197 (198) alignment 
Range on Protein: 65-260
Range on HMM: 1-197/198.0
ITIVGDIHGQLDALIRYFDAVGYPPKVKFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHSVHLLRGNHECMKMNRLYGFYEELA-RKRGGRMWRQYQNVFN
.|..||.||||| |.. |.  . .|. |.||||||||||.||.|| |||...|..||..|||||||||. |.|..|||..|.  .| | ..... |.||.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

ELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPltCDEGLQVDLM----WADPTQDKcnTFAMNKQRAISVVFGEKGLDVFLKKLGLSLIVRAHE
 |||.| . ...|..|||.|........ |  .....   ..||. .||.    . ||....  ..  |..| ....||..  . .|.|  |.||.||||
lLplaalidekvlvvHGGlseeiklldqikkeerkies..peegklldlleeeklsdpkeke..ellansarGagllfgpdvteelleknklkliiRaHe

V
|
v
PPP_4 65-260 2e-62 203.7 In-house 1-196 (197) alignment 
Range on Protein: 65-260
Range on HMM: 1-196/197.0
ITIVGDIHGQLDALIRYFDAV-GYPP-KVKFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHSVHLLRGNHECMKMNRLYGFYEELARKRGGRMWRQYQNVF
.|.||||||||| |. ..  . | |. . ...|||||||||..|.|| |||...|..||. |.|||||||....|.||||..|. .|.| ..... |.||
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvf

NELPLCARVGQRILCMHGGISQNCNSWESFKALKKPnTPLTCDEGLQVDL-MWADPTqDKCNTfAMNKQRAISVVFGEKGLDVFLKKLGLSLIVRAHEV
. |||.| . ...|..|||.|....|... ...... .. ...|..  || .|.||. .. ..   |..| ....||..  . ||.| .|.||.|.||.
dllplaalidekvlvvhgglsdelesldkierierk.iespleeekrkdlllwsdpr.eaqeg.lansvrGagllFgpdvtekfleknnlkliirshel
subfamily_PPP6C_pd Subfamily PPP6C 53-302 7.1e-62 202.1 In-house 32-277 (290) alignment 
Range on Protein: 53-302
Range on HMM: 32-277/290.0
NPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVKFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHSVHLLRGNHECMKMNRLYGFYEELARKRGG
    ..  |. |.|..||||||.  |   | . |  |. ...||||.||||  |.|   .|.. |..||. . |||||||. .. ..||||.|  .| | 
leesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesrqitqvygfydeclnkygn

-RMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTplTCDEGLQVDLMWADPtqDKCNTFAMNkQRAISVVFGEKGLDVFLKKLGL
   |. . .||. |...| . ...||.|||.| . .  .. . ... .      .|  .||.|.||  .. .|.|.  .|    .||.|  . |..   |
anawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqe..iphkgafcdlvwsdp..edvetwavs.prgagylfgskvtkefvhinnl

SLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSESYEIS
.||.|||.. .||... |..| |||.||| ||    |  .|...... | .
klicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeere
PPP_5_Dcr2 65-260 4.3e-60 196.1 In-house 1-198 (199) alignment 
Range on Protein: 65-260
Range on HMM: 1-198/199.0
ITIVGDIHGQLDAL-IRYFDAVGYPP-KVKFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHSVHLLRGNHECMKMNRLYGFYEELARK-RGGRMWRQYQNV
.|..||.||||| | .. |. .| |. . ...|||||||||..|.|| |||...|..||. |||||||||....|..|||..|  .|  | ....  ..|
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPnTPLTCDEGLQVDL-MWADPTqDKCNTFAMNKQRAISVVFGEKGLDVFLKKLGLSLIVRAHEV
|..|||.| . ...|..|||.|....|.|. ...... .... ..| . || .|.||. |....   |..| ....||..  . ||.| .|.||.|.||.
fdwlPlaalidekvlvvhgglspeiksiellekierk.ieipeekgekadlllwsdpr.daqegcklnseRGagllfgpdvtekfleknnlkliirshel
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 44-319 3.7e-59 193.4 In-house 28-298 (307) alignment 
Range on Protein: 44-319
Range on HMM: 28-298/307.0
ILEKAESTLNPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVKFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHSVHLLRGNHECMKMNRLYGFY
.. .|.. .    |..... |  .|||.|||.. ||  |  .| ||.  ..| |||||||  |.|. ||||.||| ||... |||||||  ..|. ||||
viyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygfy

EELA---RKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTplTCDEGLQVDLMWADPTQDKCNTFAmnKQRAISVVFGEK
||      | |  .|  .| .||.||. | .  .|||||||.|      . ..   ||        |.  |..||||     .  |    |   . || .
eecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpir..npfrgivndmlwadpdpsvfewka..ssrgsgftfgtn

GLDVFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSESYEISFTVLRPrmiaTPENIEI
 .|   |.||. ||.|||..  .|.  |  .| .|.|||| ||    |.|....| |.  |    . |    . |||| 
viddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvp....eseniek
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 92-309 3.9e-59 193.4 In-house 121-334 (339) alignment 
Range on Protein: 92-309
Range on HMM: 121-334/339.0
KFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHSVHLLRGNHECMKMNRLYGFYEELARKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWES
..||||||||||  |.|| .|| . |. ||  ..|||||||   .|  |||| |.  .   ...  .||.|| .|.|| . . |.|||||||.   |.. 
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfnq

FKALKKPNTplTCDEGLQVDLMWADPtqDKCNTFAMNKQRAISVVFGEKGLDVFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGA
|  .|.|      | |.  || ||||  |  .       |  |.|||   |  ||||| | ...| |.| ..|..|.  .. ||.|||| |||.. |  |
fsvfkrple..ipdvgvltdltwadp..dptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaa

IMHVSESYEISFTVLRPR
.. . .  .||  |.|| 
vfsidkklkisinvfrpe
subfamily_PPG1_pd Subfamily PPG1 40-306 1.5e-58 191.4 In-house 18-293 (300) alignment 
Range on Protein: 40-306
Range on HMM: 18-293/300.0
QIYTILEKAESTLNPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYPPKVKFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHSVHLLRGNHECMKMNRL
 .  . .|    |     . ... |.|.|||.|||.  ..  |.  |  |  ..||||||||||  | |   || . |.|||  ..|||||||  .. . 
tvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrqitqv

YGFYEELARKRGG--RMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTplTCDEGLQVDLMWADPT---------QDKCNTFAMN
|||| |  || ||  |.|. . ..|. | |.| . . | |.|||.| .. | .  | | . .     .||   ||.|.||           |.   . ..
ygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfre..vpnegaladllwsdpeennnptldhpdregqhfvv

KQRAISVVFGEKGLDVFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSESYEISFTVL
 ||     .|..    ||..  .  |.|||.. .||.. ||..|  ||.||| ||    |  .|. . |  |  | | 
sqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvy
subfamily_PPPLV_pd Subfamily PPPLV 44-297 8.4e-49 159.4 In-house 5-277 (290) alignment 
Range on Protein: 44-297
Range on HMM: 5-277/290.0
ILEKAESTLNPLPAMLQVEHPITIVGDIHGQLDALIrYFDAVGYPP-----KVKFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHSVHLLRGNHECMKMNR
. ..|   |     .|... |. ..||.||.   || ||. | .         ..||||||||||  |.|.   |.  |. ||  |.|||||||   .  
lcdvavdilaaeerllelksptyvlgdlhgnyrdli.yfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqe

LYGFYEELARKRGGR---MWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFKALKKPNTPLTCD---EGLQVDLMWADPTQDK----------C
 . .. |   | | .   .|  ..|||. ||| | . ....|.|.|| .   .     |...    |  |     | .|..|.|| .|.           
sieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvln

NTFAMNKQRAISVVFGEKGLDVFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNdTNCGAIMHVSE
. |. |..|  . ||.|. |. |||. .|| ..||||| ..|...  . . .||||.  |||  .|  |.. |..
eGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGs.sneaalilvdk
Metallophos Calcineurin-like phosphoesterase 63-260 3.4e-41 134.7 Pfam-A 1-198 (200) alignment 
Range on Protein: 63-260
Range on HMM: 1-198/200.0
HPITIVGDIHGQLDAL----IRYFDAVGYPPKVKFLFLGDYVDRGAKSFEVSLLL--FCYKIRYPHSVHLLRGNHECMKMNRLYGFYEELA---------
..|...||.||.|| |     ..... ....   .|||||.||||  | |.  ||  ...|...|. |.|||||||.. .|  |||..| .         
lrilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglang

-------------------------RKRGGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNCNSWESFkalkkpntpltcdeglqvdlmwadptqdkc
                          ..|.. ... ...|..|||.| |...||..||..|   .|..                                
eeeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi..............................

ntfamnkqraISVVFGEKGLDVFLKKLGLSLIVRAHEV
           |. ||.. |. .|.| |. |..|.|. 
..........gselfgpdalekllekygvdlvlrGHtH
subfamily_PPP7C_pd Subfamily PPP7C 32-186 4.4e-36 117.4 In-house 29-191 (383) alignment 
Range on Protein: 32-186
Range on HMM: 29-191/383.0
VTDAFNDKQIYTILEKAESTLNPLPAMLQVE----HPITIVGDIHGQLDALIRYFDAVGYPP-KVKFLFLGDYVDRGAKSFEVSLLLFCYKIRYPHSVHL
.   .  | . .|| .|. .|. || . .|.    . .|. ||.||.|| |.  .   |.|  .  ..| ||.|||| .| |. |.|... . ||..|.|
ekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevyl

LRGNHECMKMNRLYGFYEELARKR---GGRMWRQYQNVFNELPLCARVGQRILCMHGGISQNC
 ||||| . .|  |||  |.  |    | .. |. ..||  |||.. . ..|| .|||||.. 
nrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdkt
subfamily_PPP7C_pd Subfamily PPP7C 206-299 6.1e-18 57.7 In-house 233-325 (383) alignment 
Range on Protein: 206-299
Range on HMM: 233-325/383.0
EGLQ-VDLMWADPTQDKCNtfAMNKQRAISVVFGEKGLDVFLKKLGLSLIVRAHEVSQEGFNFLFNKKCVTVFSAPYYCGNDTNCGAIMHVSESY
|  | .|..|.|| ...      |  |   . ||    . .|.| .|.|..|.||  .||..|  .||..|.|||  |  . .| || ...... 
ewrqvldilwsdpkakeGc..kpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdl
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 34-88 2.3e-09 29.8 In-house 7-61 (317) alignment 
Range on Protein: 34-88
Range on HMM: 7-61/317.0
DAFNDKQIYTILEKAESTLNPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYP
| |..|... .  .|  ..   | .|..| |.||||||||| . |.  .|  |.|
dlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwp
subfamily_YNL217W_pd Subfamily YNL217W 64-149 6.5e-09 28.6 In-house 11-87 (235) alignment 
Range on Protein: 64-149
Range on HMM: 11-87/235.0
PITIVGDIHGQLDALIRYFD--AVGYPPKVKFLFLGDYVDRGAKSFEVSLLLfcykirYPHSVHLLRGNHECMKMNRLygfyeELARK
 . .|||.||  | ||. .|  ..|  . |  ...|| ...| || ||  ..        . |. ..|||| . . ..     .. .|
rllvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllay.....kwvkk
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 41-88 1e-06 21.1 In-house 16-63 (339) alignment 
Range on Protein: 41-88
Range on HMM: 16-63/339.0
IYTILEKAESTLNPLPAMLQVEHPITIVGDIHGQLDALIRYFDAVGYP
.  .  .|   .   | .|..| || ..||||||.| |.  .|  |.|
laelchrareliwsepiflkleapicvmgdihgqfddllamldmngwp
Metallophos_2 Calcineurin-like phosphoesterase superfamily domain 65-184 3.5e-06 19.1 Pfam-A 3-93 (156) alignment 
Range on Protein: 65-184
Range on HMM: 3-93/156.0
ITIVGDIHGQLDALIRYFDAVgyPPKVKFLFLGDYVDRgaksFEVSLLLfcYKIryPhsVHLLRGNHEcmkmnrlygfY----------Eelarkrggrm
| |..|.||.|||| .  ...        |..||.|..    .||  ||   .|  |  |. .||||.          .                     
iaiiSDlHgnldaleavledi..kevdlilhaGDlvep....eevvell..edi..p..vlavrGnhD..........eaelpkelavel..........

wrqyqnvFN-------ElplcarvGQRILCMHGGISQ
       ..       |       |.|.| .||   .
.......llaaaaleie.......gdrvllvhgtpls